Homo sapiens

152 known processes

PRKDC

protein kinase, DNA-activated, catalytic polypeptide

(Aliases: p350,DNAPK,HYRC1,DNA-PKcs,DNPK1,HYRC,XRCC7)

PRKDC biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
double strand break repair GO:0006302 101 1.000
cellular response to dna damage stimulus GO:0006974 379 1.000
mitotic cell cycle process GO:1903047 286 0.997
dna conformation change GO:0071103 113 0.997
mitotic cell cycle GO:0000278 326 0.995
nucleoside monophosphate catabolic process GO:0009125 159 0.989
purine nucleoside monophosphate catabolic process GO:0009128 158 0.988
positive regulation of dna metabolic process GO:0051054 73 0.986
dna geometric change GO:0032392 32 0.985
chromatin organization GO:0006325 351 0.981
regulation of dna metabolic process GO:0051052 153 0.979
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.978
ribonucleoside monophosphate catabolic process GO:0009158 158 0.976
atp metabolic process GO:0046034 176 0.976
negative regulation of cell cycle phase transition GO:1901988 89 0.971
ribonucleoside monophosphate metabolic process GO:0009161 187 0.970
negative regulation of cell death GO:0060548 345 0.969
organophosphate catabolic process GO:0046434 430 0.962
dna repair GO:0006281 198 0.959
cell cycle checkpoint GO:0000075 117 0.958
dna packaging GO:0006323 77 0.954
negative regulation of programmed cell death GO:0043069 321 0.949
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.941
chromatin assembly or disassembly GO:0006333 78 0.939
nucleoside monophosphate metabolic process GO:0009123 191 0.937
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.933
dna recombination GO:0006310 77 0.933
double strand break repair via nonhomologous end joining GO:0006303 10 0.929
regulation of cell cycle phase transition GO:1901987 126 0.926
atp catabolic process GO:0006200 157 0.925
purine nucleoside monophosphate metabolic process GO:0009126 186 0.922
mitotic cell cycle phase transition GO:0044772 162 0.919
telomere maintenance GO:0000723 32 0.918
nucleoside triphosphate metabolic process GO:0009141 422 0.912
negative regulation of apoptotic process GO:0043066 316 0.909
regulation of growth rate GO:0040009 1 0.905
determination of adult lifespan GO:0008340 2 0.904
dna dependent dna replication GO:0006261 44 0.900
mitotic nuclear division GO:0007067 119 0.884
purine nucleoside triphosphate metabolic process GO:0009144 412 0.882
post embryonic development GO:0009791 2 0.880
nucleoside triphosphate catabolic process GO:0009143 394 0.876
dna damage checkpoint GO:0000077 68 0.855
ribonucleoside catabolic process GO:0042454 406 0.851
purine nucleoside triphosphate catabolic process GO:0009146 392 0.846
nucleoside catabolic process GO:0009164 408 0.843
non recombinational repair GO:0000726 14 0.834
mitotic sister chromatid segregation GO:0000070 53 0.834
regulation of mitotic cell cycle GO:0007346 189 0.824
nuclear division GO:0000280 128 0.822
organelle localization GO:0051640 84 0.818
organelle fission GO:0048285 149 0.808
g2 dna damage checkpoint GO:0031572 26 0.803
dna duplex unwinding GO:0032508 30 0.796
response to abiotic stimulus GO:0009628 336 0.795
chromatin modification GO:0016568 298 0.778
apoptotic signaling pathway GO:0097190 268 0.777
dna integrity checkpoint GO:0031570 71 0.771
covalent chromatin modification GO:0016569 254 0.769
ribonucleoside triphosphate metabolic process GO:0009199 412 0.768
regulation of cellular component biogenesis GO:0044087 281 0.760
neuron differentiation GO:0030182 138 0.742
purine containing compound catabolic process GO:0072523 411 0.728
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.722
nucleotide catabolic process GO:0009166 408 0.721
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.713
purine ribonucleoside catabolic process GO:0046130 398 0.698
mitotic cell cycle checkpoint GO:0007093 68 0.670
embryo development GO:0009790 123 0.669
meiotic chromosome segregation GO:0045132 4 0.663
regulation of cell cycle GO:0051726 393 0.649
sister chromatid segregation GO:0000819 54 0.616
ribonucleoside triphosphate catabolic process GO:0009203 391 0.611
cellular response to abiotic stimulus GO:0071214 117 0.611
regulation of double strand break repair GO:2000779 22 0.591
purine ribonucleoside metabolic process GO:0046128 437 0.584
positive regulation of cellular component organization GO:0051130 376 0.584
establishment of protein localization to organelle GO:0072594 172 0.583
purine nucleotide catabolic process GO:0006195 405 0.575
generation of neurons GO:0048699 152 0.572
cell cycle phase transition GO:0044770 173 0.557
dna double strand break processing GO:0000729 10 0.546
regulation of chromatin assembly or disassembly GO:0001672 6 0.531
negative regulation of cell cycle GO:0045786 193 0.513
chromatin remodeling GO:0006338 55 0.508
ribonucleotide catabolic process GO:0009261 405 0.508
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.508
mitotic dna integrity checkpoint GO:0044774 30 0.496
regulation of cell cycle process GO:0010564 266 0.495
glycosyl compound catabolic process GO:1901658 413 0.466
isotype switching GO:0045190 3 0.463
base excision repair GO:0006284 21 0.461
chromosome condensation GO:0030261 15 0.449
response to uv GO:0009411 73 0.445
cell division GO:0051301 168 0.427
response to radiation GO:0009314 151 0.424
purine nucleoside catabolic process GO:0006152 398 0.420
dna strand elongation involved in dna replication GO:0006271 3 0.409
establishment of organelle localization GO:0051656 59 0.409
dna strand elongation GO:0022616 5 0.401
female gamete generation GO:0007292 2 0.400
nucleus organization GO:0006997 28 0.393
negative regulation of cell cycle process GO:0010948 121 0.391
cell aging GO:0007569 52 0.385
mitotic dna damage checkpoint GO:0044773 28 0.381
chromatin silencing GO:0006342 12 0.380
protein autoprocessing GO:0016540 4 0.369
dna replication GO:0006260 116 0.354
cellular macromolecule catabolic process GO:0044265 380 0.333
circulatory system development GO:0072359 262 0.332
response to oxygen containing compound GO:1901700 369 0.329
regulation of meiotic cell cycle GO:0051445 4 0.327
regulation of response to dna damage stimulus GO:2001020 94 0.319
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.317
segmentation GO:0035282 4 0.315
metaphase plate congression GO:0051310 18 0.296
negative regulation of mitotic cell cycle GO:0045930 102 0.294
regulation of multi organism process GO:0043900 157 0.294
actin filament based process GO:0030029 224 0.288
embryo development ending in birth or egg hatching GO:0009792 34 0.283
oogenesis GO:0048477 2 0.283
cell projection organization GO:0030030 252 0.282
double strand break repair via homologous recombination GO:0000724 50 0.278
aging GO:0007568 66 0.275
chromatin assembly GO:0031497 61 0.267
positive regulation of programmed cell death GO:0043068 249 0.260
positive regulation of chromatin assembly or disassembly GO:0045799 2 0.260
amine metabolic process GO:0009308 44 0.255
meiosis i GO:0007127 4 0.250
cellular amino acid metabolic process GO:0006520 116 0.249
mrna processing GO:0006397 133 0.239
response to ionizing radiation GO:0010212 65 0.238
protein catabolic process GO:0030163 325 0.235
cellular amine metabolic process GO:0044106 41 0.233
telomere organization GO:0032200 33 0.227
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.218
single organism cellular localization GO:1902580 332 0.217
growth GO:0040007 202 0.216
regulation of dna repair GO:0006282 47 0.216
cardiovascular system development GO:0072358 262 0.212
chemotaxis GO:0006935 157 0.208
cell activation involved in immune response GO:0002263 30 0.207
nucleoside phosphate catabolic process GO:1901292 412 0.201
regulation of chromosome segregation GO:0051983 44 0.198
ras protein signal transduction GO:0007265 73 0.197
negative regulation of dna metabolic process GO:0051053 57 0.194
meiotic cell cycle GO:0051321 13 0.193
heterochromatin organization GO:0070828 6 0.189
regulation of anatomical structure morphogenesis GO:0022603 286 0.186
regulation of nuclear division GO:0051783 65 0.173
cellular component morphogenesis GO:0032989 314 0.164
microtubule based process GO:0007017 210 0.163
cellular response to uv GO:0034644 32 0.160
endomembrane system organization GO:0010256 196 0.160
oocyte development GO:0048599 1 0.160
response to other organism GO:0051707 261 0.158
intrinsic apoptotic signaling pathway GO:0097193 127 0.157
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.155
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.155
double strand break repair via single strand annealing GO:0045002 4 0.152
viral process GO:0016032 146 0.152
regulation of binding GO:0051098 111 0.145
positive regulation of cell cycle GO:0045787 140 0.142
positive regulation of developmental process GO:0051094 314 0.142
cellular macromolecular complex assembly GO:0034622 324 0.141
membrane organization GO:0061024 292 0.141
protein import GO:0017038 130 0.140
neuron development GO:0048666 113 0.137
positive regulation of cell death GO:0010942 263 0.135
cell type specific apoptotic process GO:0097285 125 0.134
nervous system development GO:0007399 293 0.133
positive regulation of hydrolase activity GO:0051345 331 0.133
mrna metabolic process GO:0016071 175 0.126
histone modification GO:0016570 251 0.124
lymphocyte activation GO:0046649 133 0.123
cellular response to ionizing radiation GO:0071479 32 0.122
anatomical structure homeostasis GO:0060249 100 0.119
regulation of mitosis GO:0007088 63 0.118
rna export from nucleus GO:0006405 33 0.118
regulation of gene expression epigenetic GO:0040029 73 0.118
lipid metabolic process GO:0006629 381 0.118
single strand break repair GO:0000012 6 0.117
positive regulation of transport GO:0051050 336 0.117
leukocyte activation GO:0045321 164 0.116
positive regulation of growth GO:0045927 58 0.116
regulation of protein complex assembly GO:0043254 147 0.115
dna catabolic process GO:0006308 49 0.114
cell morphogenesis GO:0000902 296 0.114
gene silencing GO:0016458 49 0.113
response to light stimulus GO:0009416 87 0.113
multicellular organismal aging GO:0010259 3 0.113
protein processing GO:0016485 226 0.112
reproduction GO:0000003 63 0.111
mitotic recombination GO:0006312 8 0.111
single organism membrane organization GO:0044802 268 0.107
neurogenesis GO:0022008 169 0.105
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.104
regulation of cellular amine metabolic process GO:0033238 11 0.104
regulation of cellular response to stress GO:0080135 244 0.103
regulation of protein localization GO:0032880 296 0.102
chordate embryonic development GO:0043009 34 0.102
neuron projection development GO:0031175 106 0.100
positive regulation of transferase activity GO:0051347 227 0.100
somatic diversification of immune receptors GO:0002200 8 0.100
dna ligation GO:0006266 10 0.098
mismatch repair GO:0006298 15 0.097
regulation of tor signaling GO:0032006 30 0.096
regulation of dna recombination GO:0000018 23 0.096
rna interference GO:0016246 4 0.094
meiotic nuclear division GO:0007126 10 0.093
positive regulation of cell proliferation GO:0008284 301 0.093
regulation of establishment of protein localization GO:0070201 242 0.092
digestive tract morphogenesis GO:0048546 56 0.091
peptidyl serine phosphorylation GO:0018105 101 0.089
response to external biotic stimulus GO:0043207 261 0.088
nuclear transport GO:0051169 179 0.087
macromolecule methylation GO:0043414 97 0.086
regulation of growth GO:0040008 165 0.085
regulation of nervous system development GO:0051960 88 0.084
negative regulation of organelle organization GO:0010639 126 0.084
mitotic centrosome separation GO:0007100 1 0.082
chromosome segregation GO:0007059 114 0.081
single organism carbohydrate metabolic process GO:0044723 193 0.080
response to biotic stimulus GO:0009607 276 0.079
positive regulation of organelle organization GO:0010638 195 0.078
hematopoietic stem cell differentiation GO:0060218 4 0.076
reciprocal dna recombination GO:0035825 4 0.075
telomere maintenance via recombination GO:0000722 4 0.075
cell growth GO:0016049 160 0.075
signal transduction in response to dna damage GO:0042770 57 0.073
cell fate determination GO:0001709 3 0.072
single organism nuclear import GO:1902593 104 0.071
regulation of cellular component movement GO:0051270 334 0.070
cell morphogenesis involved in differentiation GO:0000904 144 0.070
positive regulation of protein complex assembly GO:0031334 86 0.070
reciprocal meiotic recombination GO:0007131 4 0.070
positive regulation of heterochromatin assembly GO:0031453 1 0.069
positive regulation of apoptotic process GO:0043065 246 0.069
signal transduction by p53 class mediator GO:0072331 72 0.069
positive regulation of cellular component biogenesis GO:0044089 158 0.067
positive regulation of protein transport GO:0051222 135 0.065
response to hypoxia GO:0001666 96 0.065
carbohydrate derivative biosynthetic process GO:1901137 207 0.065
ribosomal protein import into nucleus GO:0006610 2 0.065
ameboidal type cell migration GO:0001667 135 0.064
viral life cycle GO:0019058 132 0.063
regulation of cell cycle g1 s phase transition GO:1902806 42 0.063
nuclear pore complex assembly GO:0051292 7 0.062
protein maturation GO:0051604 233 0.061
mitotic spindle organization GO:0007052 27 0.060
cell activation GO:0001775 213 0.059
nuclear import GO:0051170 106 0.059
protein localization to organelle GO:0033365 280 0.059
b cell activation GO:0042113 33 0.059
response to hormone GO:0009725 175 0.056
neuron death GO:0070997 65 0.055
negative regulation of cellular component organization GO:0051129 235 0.055
protein autophosphorylation GO:0046777 123 0.054
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.053
positive regulation of cytoplasmic transport GO:1903651 82 0.053
cell development GO:0048468 328 0.053
somatic cell dna recombination GO:0016444 6 0.053
response to organonitrogen compound GO:0010243 156 0.052
mitotic g2 m transition checkpoint GO:0044818 9 0.052
regulation of protein binding GO:0043393 66 0.052
organonitrogen compound biosynthetic process GO:1901566 200 0.051
protein adp ribosylation GO:0006471 9 0.051
blastocyst development GO:0001824 3 0.051
lipid biosynthetic process GO:0008610 177 0.051
regulation of chromatin modification GO:1903308 51 0.051
cellular protein complex assembly GO:0043623 188 0.050
translation GO:0006412 132 0.050
regulation of heterochromatin assembly GO:0031445 1 0.050
nucleocytoplasmic transport GO:0006913 176 0.049
rna transport GO:0050658 39 0.049
intracellular protein transport GO:0006886 270 0.049
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.048
cell cycle arrest GO:0007050 71 0.047
response to gamma radiation GO:0010332 14 0.047
regulation of cellular ketone metabolic process GO:0010565 50 0.047
regulation of chromatin assembly GO:0010847 2 0.046
single organism reproductive process GO:0044702 98 0.045
regulation of dna methylation GO:0044030 2 0.044
histone exchange GO:0043486 3 0.044
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.044
dna damage response detection of dna damage GO:0042769 3 0.044
regulation of cytoplasmic transport GO:1903649 149 0.043
cellular ketone metabolic process GO:0042180 80 0.042
purine ribonucleotide catabolic process GO:0009154 404 0.042
enzyme linked receptor protein signaling pathway GO:0007167 303 0.042
recombinational repair GO:0000725 50 0.042
negative regulation of cellular protein metabolic process GO:0032269 353 0.042
dna unwinding involved in dna replication GO:0006268 2 0.041
generation of precursor metabolites and energy GO:0006091 68 0.040
immune system development GO:0002520 195 0.040
embryonic morphogenesis GO:0048598 85 0.039
response to oxidative stress GO:0006979 121 0.039
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.039
regeneration GO:0031099 4 0.039
regulation of nucleocytoplasmic transport GO:0046822 98 0.039
glycoprotein biosynthetic process GO:0009101 91 0.038
regulation of cell morphogenesis GO:0022604 153 0.038
positive regulation of multi organism process GO:0043902 56 0.038
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.038
cellular response to oxygen containing compound GO:1901701 276 0.038
macromolecule glycosylation GO:0043413 63 0.038
tube development GO:0035295 125 0.038
small gtpase mediated signal transduction GO:0007264 78 0.038
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.038
regulation of mitotic cell cycle phase transition GO:1901990 118 0.037
meiotic cell cycle process GO:1903046 8 0.037
mitotic chromosome condensation GO:0007076 11 0.037
pattern specification process GO:0007389 43 0.037
peptidyl lysine modification GO:0018205 144 0.037
taxis GO:0042330 157 0.037
somatic diversification of immunoglobulins GO:0016445 6 0.036
cellular response to insulin stimulus GO:0032869 41 0.035
positive regulation of response to dna damage stimulus GO:2001022 43 0.035
dna ligation involved in dna repair GO:0051103 4 0.035
regulation of cell development GO:0060284 161 0.035
multi organism cellular process GO:0044764 156 0.034
positive regulation of cell differentiation GO:0045597 211 0.034
hematopoietic progenitor cell differentiation GO:0002244 38 0.034
maintenance of dna repeat elements GO:0043570 4 0.034
regulation of viral process GO:0050792 103 0.034
regulation of neuron apoptotic process GO:0043523 35 0.034
heterochromatin assembly GO:0031507 6 0.033
cytoplasmic transport GO:0016482 379 0.033
regulation of cell division GO:0051302 116 0.033
microtubule cytoskeleton organization GO:0000226 176 0.033
regulation of transcription by chromatin organization GO:0034401 1 0.033
regulation of small gtpase mediated signal transduction GO:0051056 156 0.032
dna methylation or demethylation GO:0044728 19 0.032
smad protein import into nucleus GO:0007184 13 0.032
development of primary sexual characteristics GO:0045137 35 0.032
oocyte differentiation GO:0009994 2 0.032
negative regulation of neuron apoptotic process GO:0043524 23 0.031
positive regulation of kinase activity GO:0033674 204 0.031
regulation of cellular amino acid metabolic process GO:0006521 6 0.031
cellular response to oxygen levels GO:0071453 55 0.030
positive regulation of phosphorylation GO:0042327 394 0.030
regulation of chromatin organization GO:1902275 56 0.030
interstrand cross link repair GO:0036297 3 0.030
tor signaling GO:0031929 39 0.030
regulation of chromosome organization GO:0033044 103 0.029
histone methylation GO:0016571 60 0.029
methylation GO:0032259 106 0.029
regulation of dna replication GO:0006275 68 0.029
system process GO:0003008 349 0.029
regulation of developmental growth GO:0048638 30 0.029
nucleotide excision repair GO:0006289 31 0.028
ribonucleoprotein complex subunit organization GO:0071826 81 0.028
positive regulation of cell development GO:0010720 92 0.028
immune response GO:0006955 307 0.028
regulation of response to external stimulus GO:0032101 222 0.028
immune effector process GO:0002252 159 0.028
regulation of helicase activity GO:0051095 8 0.028
regulation of ras protein signal transduction GO:0046578 155 0.028
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.028
positive regulation of viral process GO:0048524 37 0.028
leukocyte activation involved in immune response GO:0002366 30 0.027
actin cytoskeleton organization GO:0030036 207 0.027
rna catabolic process GO:0006401 71 0.027
regulation of proteolysis GO:0030162 293 0.026
microtubule polymerization or depolymerization GO:0031109 37 0.026
molting cycle GO:0042303 28 0.026
mitotic dna replication checkpoint GO:0033314 2 0.026
compound eye development GO:0048749 1 0.026
response to purine containing compound GO:0014074 40 0.026
cell projection morphogenesis GO:0048858 129 0.026
response to starvation GO:0042594 59 0.026
epithelium development GO:0060429 227 0.026
positive regulation of immune system process GO:0002684 283 0.025
positive regulation of isotype switching to iga isotypes GO:0048298 2 0.025
regulation of protein processing GO:0070613 150 0.025
reproductive system development GO:0061458 56 0.025
cell part morphogenesis GO:0032990 137 0.025
vasculature development GO:0001944 181 0.025
regulation of cell migration GO:0030334 289 0.025
regulation of cell growth GO:0001558 135 0.025
neuron apoptotic process GO:0051402 39 0.024
negative regulation of neuron death GO:1901215 32 0.024
positive regulation of protein kinase activity GO:0045860 190 0.024
regulation of cell motility GO:2000145 299 0.024
regulation of cell differentiation GO:0045595 393 0.024
rna processing GO:0006396 255 0.024
organ morphogenesis GO:0009887 147 0.023
histone h3 k4 methylation GO:0051568 27 0.023
regulation of cysteine type endopeptidase activity GO:2000116 127 0.023
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.023
chromatin remodeling at centromere GO:0031055 2 0.023
stem cell differentiation GO:0048863 93 0.022
regulation of kinase activity GO:0043549 314 0.022
regulation of viral genome replication GO:0045069 48 0.022
carbohydrate metabolic process GO:0005975 207 0.022
positive regulation of protein phosphorylation GO:0001934 313 0.022
blood vessel morphogenesis GO:0048514 162 0.022
cartilage development GO:0051216 31 0.021
sex determination GO:0007530 3 0.021
protein glycosylation GO:0006486 62 0.021
protein targeting to nucleus GO:0044744 104 0.020
positive regulation of chromatin modification GO:1903310 30 0.020
vesicle mediated transport GO:0016192 371 0.020
septum secundum development GO:0003285 2 0.020
regulation of cytoskeleton organization GO:0051493 177 0.020
tripartite regional subdivision GO:0007351 2 0.020
regionalization GO:0003002 29 0.020
regulation of apoptotic signaling pathway GO:2001233 175 0.020
protein poly adp ribosylation GO:0070212 3 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.020
regulation of centriole replication GO:0046599 7 0.020
protein targeting GO:0006605 187 0.020
posttranscriptional regulation of gene expression GO:0010608 213 0.019
maintenance of location GO:0051235 112 0.019
positive regulation of intracellular transport GO:0032388 104 0.019
anatomical structure formation involved in morphogenesis GO:0048646 284 0.019
rna localization GO:0006403 41 0.019
regulation of protein maturation GO:1903317 150 0.019
humoral immune response GO:0006959 49 0.019
negative regulation of intracellular signal transduction GO:1902532 183 0.019
atrial septum primum morphogenesis GO:0003289 1 0.019
eye development GO:0001654 42 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.018
purine nucleotide biosynthetic process GO:0006164 84 0.018
nucleosome assembly GO:0006334 50 0.018
nls bearing protein import into nucleus GO:0006607 2 0.018
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
cellular response to radiation GO:0071478 65 0.018
mitotic g2 dna damage checkpoint GO:0007095 7 0.018
multicellular organismal reproductive process GO:0048609 40 0.018
positive regulation of binding GO:0051099 45 0.018
dephosphorylation GO:0016311 209 0.018
negative regulation of cellular catabolic process GO:0031330 83 0.018
leukocyte differentiation GO:0002521 98 0.018
interspecies interaction between organisms GO:0044419 156 0.017
negative regulation of proteolysis GO:0045861 132 0.017
axon development GO:0061564 34 0.017
positive regulation of developmental growth GO:0048639 16 0.017
positive regulation of helicase activity GO:0051096 6 0.017
negative regulation of cell differentiation GO:0045596 171 0.017
regulation of endopeptidase activity GO:0052548 170 0.017
spindle localization GO:0051653 12 0.017
response to alkaloid GO:0043279 20 0.017
centrosome separation GO:0051299 3 0.016
gonad development GO:0008406 34 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
cellular response to organonitrogen compound GO:0071417 124 0.016
lipid localization GO:0010876 106 0.016
regulation of translation GO:0006417 89 0.016
regulation of peptidase activity GO:0052547 180 0.015
monocarboxylic acid metabolic process GO:0032787 185 0.015
regulation of intracellular protein transport GO:0033157 123 0.015
g2 m transition of mitotic cell cycle GO:0000086 41 0.015
cellular response to hormone stimulus GO:0032870 125 0.015
dna hypermethylation GO:0044026 1 0.015
response to caffeine GO:0031000 3 0.015
regulation of histone modification GO:0031056 47 0.014
organelle assembly GO:0070925 176 0.014
positive regulation of dendrite morphogenesis GO:0050775 3 0.014
hematopoietic or lymphoid organ development GO:0048534 186 0.014
regulation of angiogenesis GO:0045765 92 0.014
heart development GO:0007507 95 0.014
establishment of spindle localization GO:0051293 12 0.014
response to nitrogen compound GO:1901698 184 0.014
gastrulation GO:0007369 51 0.014
regulation of locomotion GO:0040012 329 0.014
regulation of protein localization to nucleus GO:1900180 85 0.014
negative regulation of protein maturation GO:1903318 142 0.014
multicellular organism reproduction GO:0032504 42 0.014
negative regulation of gene silencing by rna GO:0060967 3 0.014
nucleoside phosphate biosynthetic process GO:1901293 109 0.014
response to inorganic substance GO:0010035 127 0.013
muscle contraction GO:0006936 73 0.013
negative regulation of catalytic activity GO:0043086 335 0.013
hemopoiesis GO:0030097 180 0.013
intracellular mrna localization GO:0008298 1 0.013
establishment of chromosome localization GO:0051303 20 0.013
spindle organization GO:0007051 53 0.013
cellular response to light stimulus GO:0071482 34 0.013
negative regulation of hydrolase activity GO:0051346 182 0.013
protein methylation GO:0006479 74 0.013
regulation of homeostatic process GO:0032844 121 0.013
wnt signaling pathway GO:0016055 156 0.013
blastoderm segmentation GO:0007350 2 0.013
nuclear pore organization GO:0006999 10 0.013
regulation of protein targeting GO:1903533 91 0.013
spermatid development GO:0007286 4 0.013
cellular response to external stimulus GO:0071496 111 0.012

PRKDC disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.480
organ system cancer DOID:0050686 164 0.090
cancer DOID:162 167 0.090
nervous system disease DOID:863 431 0.073
neuropathy DOID:870 52 0.073