Homo sapiens

14 known processes

PSAP

prosaposin

(Aliases: MGC110993,FLJ00245,SAP1,GLBA)

PSAP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein catabolic process GO:0030163 325 0.855
negative regulation of collagen catabolic process GO:0010711 1 0.830
anatomical structure homeostasis GO:0060249 100 0.803
neurological system process GO:0050877 163 0.780
negative regulation of elastin catabolic process GO:0060311 1 0.773
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.766
vacuole organization GO:0007033 44 0.761
multicellular organismal aging GO:0010259 3 0.727
determination of adult lifespan GO:0008340 2 0.698
negative regulation of extracellular matrix disassembly GO:0010716 3 0.649
neuromuscular process GO:0050905 15 0.601
response to thyroid hormone GO:0097066 9 0.578
regulation of blood vessel remodeling GO:0060312 2 0.564
cellular macromolecule catabolic process GO:0044265 380 0.559
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.541
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.527
multicellular organismal homeostasis GO:0048871 67 0.517
tissue homeostasis GO:0001894 63 0.512
elastin catabolic process GO:0060309 1 0.490
epithelium development GO:0060429 227 0.469
Mouse
post embryonic development GO:0009791 2 0.429
chemical homeostasis GO:0048878 306 0.407
detection of chemical stimulus GO:0009593 55 0.398
maintenance of location in cell GO:0051651 62 0.355
kidney development GO:0001822 53 0.342
sensory perception of taste GO:0050909 36 0.313
system process GO:0003008 349 0.301
negative regulation of extracellular matrix organization GO:1903054 3 0.289
regulation of dendritic cell differentiation GO:2001198 3 0.283
peptide catabolic process GO:0043171 10 0.281
antigen processing and presentation via mhc class ib GO:0002475 3 0.278
locomotory behavior GO:0007626 1 0.275
cellular amino acid metabolic process GO:0006520 116 0.273
antigen processing and presentation GO:0019882 33 0.268
regulation of elastin catabolic process GO:0060310 1 0.266
sensory perception of bitter taste GO:0050913 28 0.253
sensory perception of chemical stimulus GO:0007606 38 0.227
head development GO:0060322 108 0.198
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.195
positive regulation of t cell tolerance induction GO:0002666 2 0.188
regulation of mapk cascade GO:0043408 262 0.182
Mouse
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.173
collagen catabolic process GO:0030574 10 0.172
negative regulation of multicellular organismal process GO:0051241 317 0.168
response to bacterium GO:0009617 144 0.166
regulation of cellular amine metabolic process GO:0033238 11 0.165
cellular ion homeostasis GO:0006873 168 0.165
neuromuscular process controlling balance GO:0050885 7 0.164
regulation of cellular amino acid metabolic process GO:0006521 6 0.161
cellular response to thyroid hormone stimulus GO:0097067 9 0.155
peripheral nervous system development GO:0007422 2 0.154
response to other organism GO:0051707 261 0.152
regulation of peptidase activity GO:0052547 180 0.149
cellular homeostasis GO:0019725 196 0.148
cell development GO:0048468 328 0.146
protein localization to organelle GO:0033365 280 0.136
renal system development GO:0072001 63 0.135
cellular amide metabolic process GO:0043603 69 0.130
peptide hormone processing GO:0016486 9 0.125
regulation of angiotensin levels in blood GO:0002002 3 0.124
signal transduction by phosphorylation GO:0023014 297 0.121
Mouse
reproductive process GO:0022414 106 0.112
Mouse
protein modification by small protein conjugation GO:0032446 342 0.103
antigen processing and presentation of peptide antigen GO:0048002 18 0.103
response to axon injury GO:0048678 1 0.102
cellular amine metabolic process GO:0044106 41 0.102
cellular component morphogenesis GO:0032989 314 0.102
regulation of rubidium ion transport GO:2000680 3 0.101
negative regulation of membrane protein ectodomain proteolysis GO:0051045 4 0.101
embryo development GO:0009790 123 0.101
response to biotic stimulus GO:0009607 276 0.101
negative regulation of trophoblast cell migration GO:1901164 3 0.095
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.094
neuron differentiation GO:0030182 138 0.094
monovalent inorganic cation transport GO:0015672 128 0.093
amine metabolic process GO:0009308 44 0.093
protein maturation GO:0051604 233 0.092
cellular protein catabolic process GO:0044257 261 0.091
protein ubiquitination GO:0016567 314 0.090
retina development in camera type eye GO:0060041 15 0.090
amino sugar metabolic process GO:0006040 15 0.089
single organism reproductive process GO:0044702 98 0.089
Mouse
ion homeostasis GO:0050801 230 0.088
eye development GO:0001654 42 0.088
cation transport GO:0006812 331 0.088
negative regulation of dendritic cell differentiation GO:2001199 2 0.086
necrotic cell death GO:0070265 21 0.085
peptide metabolic process GO:0006518 51 0.084
epithelial cell differentiation GO:0030855 141 0.084
Mouse
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.083
cell morphogenesis GO:0000902 296 0.082
negative regulation of programmed cell death GO:0043069 321 0.081
regulation of cellular ketone metabolic process GO:0010565 50 0.080
negative regulation of cellular protein metabolic process GO:0032269 353 0.080
nervous system development GO:0007399 293 0.079
detection of stimulus involved in sensory perception GO:0050906 43 0.079
autophagy GO:0006914 88 0.079
cellular ketone metabolic process GO:0042180 80 0.078
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.077
defense response GO:0006952 315 0.077
innate immune response GO:0045087 178 0.074
negative regulation of cell migration GO:0030336 102 0.074
membrane protein proteolysis GO:0033619 38 0.072
growth GO:0040007 202 0.071
Mouse
maintenance of location GO:0051235 112 0.071
neurogenesis GO:0022008 169 0.071
diaphragm contraction GO:0002086 1 0.067
protein processing GO:0016485 226 0.064
retina homeostasis GO:0001895 42 0.063
aging GO:0007568 66 0.063
cell projection organization GO:0030030 252 0.062
negative regulation of glycoprotein metabolic process GO:1903019 8 0.060
response to external biotic stimulus GO:0043207 261 0.058
lipid metabolic process GO:0006629 381 0.058
Mouse
detection of stimulus GO:0051606 85 0.054
negative regulation of cell death GO:0060548 345 0.054
Mouse
neuromuscular process controlling posture GO:0050884 2 0.054
regeneration GO:0031099 4 0.054
cytokine production GO:0001816 247 0.053
immune response GO:0006955 307 0.051
hematopoietic or lymphoid organ development GO:0048534 186 0.051
negative regulation of developmental process GO:0051093 247 0.050
negative regulation of cell proliferation GO:0008285 228 0.050
angiotensin maturation GO:0002003 2 0.050
apoptotic signaling pathway GO:0097190 268 0.049
blastocyst development GO:0001824 3 0.049
regulation of protein catabolic process GO:0042176 155 0.049
cilium organization GO:0044782 68 0.049
endocrine process GO:0050886 25 0.048
regulation of natural killer cell mediated immunity GO:0002715 16 0.048
leukocyte mediated immunity GO:0002443 59 0.048
regulation of defense response GO:0031347 154 0.046
regulation of cell killing GO:0031341 22 0.046
regulation of protein maturation GO:1903317 150 0.045
ubiquitin dependent protein catabolic process GO:0006511 206 0.045
proteasomal protein catabolic process GO:0010498 176 0.043
regulation of cell differentiation GO:0045595 393 0.042
cellular cation homeostasis GO:0030003 163 0.042
enzyme linked receptor protein signaling pathway GO:0007167 303 0.042
female gamete generation GO:0007292 2 0.041
modification dependent protein catabolic process GO:0019941 209 0.041
cell killing GO:0001906 34 0.041
central nervous system development GO:0007417 123 0.040
negative regulation of metalloenzyme activity GO:0048553 1 0.040
sequestering of metal ion GO:0051238 24 0.040
wnt signaling pathway GO:0016055 156 0.039
regulation of transferase activity GO:0051338 355 0.039
basement membrane organization GO:0071711 3 0.039
cellular transition metal ion homeostasis GO:0046916 21 0.039
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.037
negative regulation of apoptotic process GO:0043066 316 0.036
anatomical structure formation involved in morphogenesis GO:0048646 284 0.036
pharynx development GO:0060465 1 0.036
cell projection morphogenesis GO:0048858 129 0.036
lytic vacuole organization GO:0080171 24 0.036
muscle cell cellular homeostasis GO:0046716 3 0.036
negative regulation of peptidase activity GO:0010466 91 0.036
interferon gamma production GO:0032609 39 0.035
extracellular matrix disassembly GO:0022617 16 0.035
erbb signaling pathway GO:0038127 44 0.034
multicellular organismal metabolic process GO:0044236 34 0.034
negative regulation of catalytic activity GO:0043086 335 0.034
modification dependent macromolecule catabolic process GO:0043632 212 0.033
mapk cascade GO:0000165 288 0.032
Mouse
response to wounding GO:0009611 168 0.032
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.032
oogenesis GO:0048477 2 0.032
inner ear morphogenesis GO:0042472 4 0.031
chemical homeostasis within a tissue GO:0048875 3 0.030
regulation of collagen catabolic process GO:0010710 3 0.030
negative regulation of apoptotic signaling pathway GO:2001234 97 0.030
respiratory system process GO:0003016 3 0.030
generation of neurons GO:0048699 152 0.030
cellular metal ion homeostasis GO:0006875 146 0.030
circulatory system development GO:0072359 262 0.029
memory GO:0007613 3 0.029
hemopoiesis GO:0030097 180 0.028
antigen processing and presentation of exogenous peptide antigen GO:0002478 4 0.028
regulation of angiotensin metabolic process GO:0060177 3 0.028
neuron development GO:0048666 113 0.027
regulation of integrin mediated signaling pathway GO:2001044 3 0.027
generation of precursor metabolites and energy GO:0006091 68 0.027
steroid metabolic process GO:0008202 94 0.026
positive regulation of lymphocyte differentiation GO:0045621 13 0.026
regulation of cellular response to stress GO:0080135 244 0.026
Mouse
positive regulation of wnt signaling pathway GO:0030177 54 0.026
embryo development ending in birth or egg hatching GO:0009792 34 0.026
negative regulation of intracellular signal transduction GO:1902532 183 0.026
transition metal ion transport GO:0000041 23 0.026
oxidation reduction process GO:0055114 396 0.026
tissue regeneration GO:0042246 3 0.025
blood circulation GO:0008015 113 0.025
transition metal ion homeostasis GO:0055076 31 0.025
regulation of cell motility GO:2000145 299 0.025
muscle system process GO:0003012 81 0.025
regulation of vasculature development GO:1901342 97 0.024
immune system development GO:0002520 195 0.024
bone resorption GO:0045453 6 0.024
cytoplasmic transport GO:0016482 379 0.023
regulation of wnt signaling pathway GO:0030111 123 0.023
positive regulation of catabolic process GO:0009896 310 0.023
response to oxygen levels GO:0070482 100 0.023
skin development GO:0043588 76 0.023
cell activation GO:0001775 213 0.023
cation homeostasis GO:0055080 189 0.023
female pregnancy GO:0007565 17 0.023
establishment of planar polarity GO:0001736 3 0.023
negative regulation of leukocyte activation GO:0002695 26 0.022
negative regulation of protein processing GO:0010955 142 0.022
regulation of anatomical structure morphogenesis GO:0022603 286 0.022
regulation of exocytosis GO:0017157 46 0.022
camera type eye development GO:0043010 25 0.022
cellular chemical homeostasis GO:0055082 180 0.022
osteoclast development GO:0036035 2 0.022
response to abiotic stimulus GO:0009628 336 0.021
inorganic cation transmembrane transport GO:0098662 194 0.021
regulation of vascular endothelial growth factor signaling pathway GO:1900746 6 0.021
cellular response to oxidative stress GO:0034599 85 0.021
Mouse
negative regulation of catabolic process GO:0009895 104 0.021
regulation of epithelial cell proliferation GO:0050678 113 0.021
cerebral cortex cell migration GO:0021795 3 0.021
myeloid cell differentiation GO:0030099 117 0.021
regulation of leukocyte mediated immunity GO:0002703 38 0.021
negative regulation of protein metabolic process GO:0051248 391 0.020
epidermis development GO:0008544 59 0.020
immune effector process GO:0002252 159 0.020
sensory perception GO:0007600 103 0.020
hair cell differentiation GO:0035315 2 0.020
ganglioside catabolic process GO:0006689 3 0.020
negative regulation of cell differentiation GO:0045596 171 0.020
regulation of systemic arterial blood pressure GO:0003073 19 0.020
positive regulation of defense response GO:0031349 87 0.019
single organism carbohydrate metabolic process GO:0044723 193 0.019
cellular polysaccharide catabolic process GO:0044247 4 0.019
negative regulation of multicellular organismal metabolic process GO:0044252 3 0.019
regulation of protein processing GO:0070613 150 0.019
negative regulation of cellular amine metabolic process GO:0033239 3 0.019
exocytosis GO:0006887 71 0.019
regulation of purine nucleotide metabolic process GO:1900542 264 0.019
cellular component disassembly GO:0022411 92 0.019
cell morphogenesis involved in differentiation GO:0000904 144 0.018
monovalent inorganic cation homeostasis GO:0055067 37 0.018
regulation of feeding behavior GO:0060259 3 0.018
response to starvation GO:0042594 59 0.018
regulation of cellular response to growth factor stimulus GO:0090287 76 0.018
positive regulation of epithelial cell proliferation GO:0050679 65 0.018
regulation of kinase activity GO:0043549 314 0.018
negative regulation of hydrolase activity GO:0051346 182 0.018
negative regulation of proteolysis GO:0045861 132 0.017
cell adhesion GO:0007155 325 0.017
regulation of secretion GO:0051046 194 0.017
microtubule based process GO:0007017 210 0.017
negative regulation of endopeptidase activity GO:0010951 84 0.017
negative regulation of protein phosphorylation GO:0001933 140 0.017
positive regulation of secretion GO:0051047 116 0.017
circulatory system process GO:0003013 113 0.017
regulation of cell activation GO:0050865 125 0.017
cell type specific apoptotic process GO:0097285 125 0.017
establishment of tissue polarity GO:0007164 3 0.016
carbohydrate catabolic process GO:0016052 36 0.016
autophagic vacuole assembly GO:0000045 19 0.016
leukocyte activation GO:0045321 164 0.016
morphogenesis of a polarized epithelium GO:0001738 3 0.016
neuron projection development GO:0031175 106 0.016
embryonic organ morphogenesis GO:0048562 24 0.016
negative regulation of fibroblast proliferation GO:0048147 12 0.016
surfactant homeostasis GO:0043129 3 0.016
rubidium ion transport GO:0035826 4 0.016
detection of biotic stimulus GO:0009595 21 0.016
t cell tolerance induction GO:0002517 4 0.016
regulation of hormone levels GO:0010817 125 0.016
negative regulation of transferase activity GO:0051348 124 0.015
fibroblast proliferation GO:0048144 33 0.015
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.015
neural tube closure GO:0001843 3 0.015
cell part morphogenesis GO:0032990 137 0.015
negative regulation of vasculature development GO:1901343 43 0.015
inorganic ion transmembrane transport GO:0098660 231 0.015
positive regulation of immune system process GO:0002684 283 0.015
epithelial cell proliferation GO:0050673 128 0.015
organelle localization GO:0051640 84 0.015
involuntary skeletal muscle contraction GO:0003011 1 0.015
actin mediated cell contraction GO:0070252 12 0.015
response to hydrogen peroxide GO:0042542 40 0.015
Mouse
organelle assembly GO:0070925 176 0.015
regulation of cellular component biogenesis GO:0044087 281 0.015
regulation of t cell activation GO:0050863 77 0.015
lysosomal transport GO:0007041 33 0.015
multi organism reproductive process GO:0044703 54 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.015
cellular response to extracellular stimulus GO:0031668 72 0.015
respiratory gaseous exchange GO:0007585 3 0.015
response to hypoxia GO:0001666 96 0.014
cilium morphogenesis GO:0060271 75 0.014
regulation of innate immune response GO:0045088 97 0.014
tube closure GO:0060606 3 0.014
sensory organ development GO:0007423 52 0.014
regulation of fibroblast proliferation GO:0048145 32 0.014
behavior GO:0007610 112 0.014
protein stabilization GO:0050821 64 0.014
segmentation GO:0035282 4 0.014
cell cycle phase transition GO:0044770 173 0.014
positive regulation of cellular amine metabolic process GO:0033240 7 0.014
blastoderm segmentation GO:0007350 2 0.014
negative regulation of locomotion GO:0040013 118 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.014
carbohydrate metabolic process GO:0005975 207 0.014
proton transport GO:0015992 22 0.014
positive regulation of leukocyte differentiation GO:1902107 37 0.014
positive regulation of tolerance induction GO:0002645 2 0.014
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.014
neuronal action potential GO:0019228 9 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
Mouse
regulation of cellular component movement GO:0051270 334 0.014
heart process GO:0003015 62 0.013
regulation of membrane potential GO:0042391 95 0.013
long term memory GO:0007616 2 0.013
camp metabolic process GO:0046058 61 0.013
microtubule cytoskeleton organization GO:0000226 176 0.013
positive regulation of exocytosis GO:0045921 35 0.013
single organismal cell cell adhesion GO:0016337 148 0.013
neuron projection morphogenesis GO:0048812 50 0.013
mitotic cell cycle GO:0000278 326 0.013
regulation of homeostatic process GO:0032844 121 0.013
negative regulation of immune system process GO:0002683 136 0.013
developmental growth GO:0048589 48 0.013
Mouse
blood vessel remodeling GO:0001974 2 0.013
brain development GO:0007420 97 0.013
negative regulation of cellular component movement GO:0051271 106 0.013
memory t cell activation GO:0035709 1 0.013
positive regulation of lymphocyte activation GO:0051251 73 0.013
regulation of tolerance induction GO:0002643 4 0.013
metal ion homeostasis GO:0055065 169 0.013
negative regulation of cell motility GO:2000146 104 0.013
multicellular organismal catabolic process GO:0044243 12 0.013
regulation of blood pressure GO:0008217 30 0.013
lymphocyte mediated immunity GO:0002449 48 0.013
melanosome organization GO:0032438 7 0.013
intracellular protein transport GO:0006886 270 0.012
negative regulation of cellular catabolic process GO:0031330 83 0.012
regulation of regulatory t cell differentiation GO:0045589 4 0.012
regulation of protein kinase activity GO:0045859 289 0.012
negative regulation of defense response GO:0031348 47 0.012
positive regulation of cell killing GO:0031343 19 0.012
regulation of proteolysis GO:0030162 293 0.012
cholesterol metabolic process GO:0008203 28 0.012
pigmentation GO:0043473 22 0.012
antigen processing and presentation of peptide antigen via mhc class ii GO:0002495 11 0.012
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
divalent inorganic cation homeostasis GO:0072507 136 0.012
regulation of lymphocyte mediated immunity GO:0002706 33 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.011
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.011
purine containing compound catabolic process GO:0072523 411 0.011
endosomal transport GO:0016197 129 0.011
urogenital system development GO:0001655 65 0.011
Mouse
regulation of intracellular transport GO:0032386 195 0.011
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway tap independent GO:0002486 3 0.011
regulation of metalloenzyme activity GO:0048552 3 0.011
receptor metabolic process GO:0043112 81 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
axon extension GO:0048675 13 0.011
negative regulation of immune effector process GO:0002698 38 0.011
positive regulation of secretion by cell GO:1903532 108 0.011
immune response regulating signaling pathway GO:0002764 97 0.011
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.011
positive regulation of developmental process GO:0051094 314 0.010
i kappab kinase nf kappab signaling GO:0007249 166 0.010
cell projection assembly GO:0030031 126 0.010
developmental process involved in reproduction GO:0003006 66 0.010
Mouse
vasculature development GO:0001944 181 0.010
stem cell division GO:0017145 2 0.010
regulation of ion transport GO:0043269 189 0.010
positive regulation of innate immune response GO:0045089 79 0.010
nuclear transport GO:0051169 179 0.010
regulation of endopeptidase activity GO:0052548 170 0.010

PSAP disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 1.000
lysosomal storage disease DOID:3211 47 1.000
inherited metabolic disorder DOID:655 242 1.000
lipid storage disease DOID:9455 28 0.994
neuronal ceroid lipofuscinosis DOID:14503 11 0.799
central nervous system disease DOID:331 186 0.147
neurodegenerative disease DOID:1289 102 0.147
nervous system disease DOID:863 431 0.147
epilepsy syndrome DOID:1826 41 0.076
brain disease DOID:936 73 0.076
variable age at onset electroclinical syndrome DOID:0050706 8 0.076
electroclinical syndrome DOID:0050701 32 0.076
progressive myoclonus epilepsy DOID:891 8 0.076
glycogen storage disease DOID:2747 10 0.073
carbohydrate metabolic disorder DOID:2978 55 0.073
glycogen metabolism disorder DOID:0050728 10 0.073
mucopolysaccharidosis DOID:12798 11 0.070
mucopolysaccharidosis iii DOID:12801 4 0.053
retinal disease DOID:5679 118 0.032
retinal degeneration DOID:8466 89 0.032
degeneration of macula and posterior pole DOID:2007 17 0.032
sensory system disease DOID:0050155 203 0.032
macular degeneration DOID:4448 20 0.032
eye and adnexa disease DOID:1492 150 0.032
age related macular degeneration DOID:10871 17 0.032
eye disease DOID:5614 149 0.032
immune system disease DOID:2914 155 0.029
lymphatic system disease DOID:75 12 0.029
acquired metabolic disease DOID:0060158 58 0.022
disease of mental health DOID:150 70 0.013
cognitive disorder DOID:1561 29 0.013
disease of cellular proliferation DOID:14566 174 0.010
sphingolipidosis DOID:1927 14 0.005
cerebral degeneration DOID:1443 16 0.003
leukodystrophy DOID:10579 8 0.002