Homo sapiens

110 known processes

PSEN1

presenilin 1

(Aliases: PS-1,PS1,S182,AD3,FAD)

PSEN1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cardiac muscle cell cardiac muscle cell adhesion GO:0086042 1 1.000
cardiac muscle cell action potential involved in contraction GO:0086002 21 0.999
desmosome assembly GO:0002159 4 0.998
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 3 0.996
Mouse
negative regulation of catagen GO:0051796 1 0.993
cardiac muscle cell action potential GO:0086001 23 0.989
thymus development GO:0048538 3 0.988
Mouse
associative learning GO:0008306 1 0.986
catagen GO:0042637 3 0.985
single organismal cell cell adhesion GO:0016337 148 0.983
cell adhesion GO:0007155 325 0.981
system process GO:0003008 349 0.981
Mouse
muscle contraction GO:0006936 73 0.980
action potential GO:0001508 34 0.975
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.973
low density lipoprotein particle mediated signaling GO:0055096 1 0.971
cardiac muscle cell contraction GO:0086003 4 0.971
positive regulation of keratinocyte proliferation GO:0010838 4 0.971
regulation of membrane potential GO:0042391 95 0.970
Mouse
regulation of canonical wnt signaling pathway GO:0060828 88 0.953
cell activation GO:0001775 213 0.953
Mouse
neurological system process GO:0050877 163 0.952
Mouse
cell cell signaling GO:0007267 155 0.948
Mouse Fly
somitogenesis GO:0001756 2 0.942
Mouse
membrane protein proteolysis GO:0033619 38 0.939
biological adhesion GO:0022610 331 0.937
regulation of apoptotic signaling pathway GO:2001233 175 0.935
Mouse
cell migration involved in gastrulation GO:0042074 1 0.935
motor neuron axon guidance GO:0008045 2 0.933
multicellular organismal signaling GO:0035637 34 0.932
blood circulation GO:0008015 113 0.932
canonical wnt signaling pathway GO:0060070 116 0.931
Zebrafish
embryonic morphogenesis GO:0048598 85 0.930
Mouse
t cell activation GO:0042110 99 0.928
Mouse
neural tube development GO:0021915 9 0.925
Mouse
skin development GO:0043588 76 0.923
Mouse
endomembrane system organization GO:0010256 196 0.915
regulation of protein binding GO:0043393 66 0.911
Mouse
positive regulation of transport GO:0051050 336 0.906
negative regulation of apoptotic signaling pathway GO:2001234 97 0.904
Mouse
negative regulation of protein processing GO:0010955 142 0.901
Mouse
regulation of peptidase activity GO:0052547 180 0.900
regulation of cardiac muscle cell contraction GO:0086004 23 0.900
regulation of cell differentiation GO:0045595 393 0.897
Mouse
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.895
cellular chemical homeostasis GO:0055082 180 0.891
memory GO:0007613 3 0.886
Mouse
protein maturation GO:0051604 233 0.886
positive regulation of intracellular protein transport GO:0090316 76 0.881
regulation of protein localization GO:0032880 296 0.881
beta amyloid metabolic process GO:0050435 12 0.880
Zebrafish Mouse
protein localization to membrane GO:0072657 160 0.872
positive regulation of apoptotic signaling pathway GO:2001235 70 0.871
ubiquitin dependent protein catabolic process GO:0006511 206 0.869
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 303 0.859
Mouse
ventricular cardiac muscle cell action potential GO:0086005 15 0.856
g protein coupled receptor signaling pathway GO:0007186 207 0.852
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.849
hematopoietic or lymphoid organ development GO:0048534 186 0.844
Mouse
intermediate filament based process GO:0045103 17 0.844
single organism cell adhesion GO:0098602 179 0.842
negative regulation of developmental process GO:0051093 247 0.840
Mouse
negative regulation of wnt signaling pathway GO:0030178 69 0.839
regulation of melanosome transport GO:1902908 1 0.836
wnt signaling pathway GO:0016055 156 0.834
Zebrafish
canonical wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition GO:0044334 2 0.834
hair cycle GO:0042633 28 0.823
Mouse
protein processing GO:0016485 226 0.814
response to oxygen containing compound GO:1901700 369 0.813
cellular divalent inorganic cation homeostasis GO:0072503 128 0.809
regulation of protein maturation GO:1903317 150 0.806
Mouse
regulation of proteolysis GO:0030162 293 0.805
Mouse
keratinocyte differentiation GO:0030216 36 0.804
cardiac muscle contraction GO:0060048 34 0.798
positive regulation of catabolic process GO:0009896 310 0.797
Mouse
visual learning GO:0008542 1 0.791
negative regulation of proteolysis GO:0045861 132 0.790
Mouse
regulation of synaptic plasticity GO:0048167 3 0.786
Mouse
regulation of cardiac muscle contraction GO:0055117 33 0.785
plasma membrane organization GO:0007009 115 0.784
epithelium development GO:0060429 227 0.768
Zebrafish Mouse
single organism cellular localization GO:1902580 332 0.766
cell communication involved in cardiac conduction GO:0086065 18 0.762
heart contraction GO:0060047 62 0.760
negative regulation of protein maturation GO:1903318 142 0.759
Mouse
regulation of melanin biosynthetic process GO:0048021 1 0.756
regulation of cell cycle GO:0051726 393 0.752
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.751
regulation of wnt signaling pathway GO:0030111 123 0.747
positive regulation of protein import into nucleus GO:0042307 46 0.747
cellular homeostasis GO:0019725 196 0.746
behavior GO:0007610 112 0.744
Zebrafish Mouse
branching involved in salivary gland morphogenesis GO:0060445 1 0.743
regulation of endopeptidase activity GO:0052548 170 0.740
brain morphogenesis GO:0048854 1 0.739
Mouse
actin mediated cell contraction GO:0070252 12 0.739
lymphocyte activation GO:0046649 133 0.739
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.736
negative regulation of ubiquitin protein transferase activity GO:0051444 8 0.735
Mouse
actin filament based movement GO:0030048 17 0.719
rho protein signal transduction GO:0007266 26 0.715
heart process GO:0003015 62 0.715
positive regulation of programmed cell death GO:0043068 249 0.714
Mouse
protein localization to adherens junction GO:0071896 2 0.713
positive regulation of nucleotide metabolic process GO:0045981 230 0.713
receptor metabolic process GO:0043112 81 0.713
Mouse
cardiovascular system development GO:0072358 262 0.712
Zebrafish Mouse
regulation of heart rate GO:0002027 38 0.708
salivary gland morphogenesis GO:0007435 4 0.703
regulation of protein ubiquitination GO:0031396 95 0.693
Mouse
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.686
protein localization to plasma membrane GO:0072659 93 0.685
membrane protein ectodomain proteolysis GO:0006509 33 0.675
positive regulation of cell death GO:0010942 263 0.672
Mouse
embryonic appendage morphogenesis GO:0035113 9 0.667
Mouse
embryo development GO:0009790 123 0.665
Zebrafish Mouse
positive regulation of secretion by cell GO:1903532 108 0.664
striated muscle contraction GO:0006941 52 0.661
cardiac muscle tissue development GO:0048738 39 0.661
positive regulation of secretion GO:0051047 116 0.660
notch receptor processing GO:0007220 2 0.656
Mouse Fly
cellular amide metabolic process GO:0043603 69 0.656
Zebrafish Mouse
leukocyte differentiation GO:0002521 98 0.655
Mouse
regulation of protein catabolic process GO:0042176 155 0.654
Mouse
epithelial cell proliferation GO:0050673 128 0.647
Mouse
smooth muscle cell proliferation GO:0048659 28 0.645
regulation of protein transport GO:0051223 213 0.643
cytokine production GO:0001816 247 0.642
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.641
cell cell adhesion involved in gastrulation GO:0070586 6 0.640
regulation of cellular amino acid metabolic process GO:0006521 6 0.638
cellular ion homeostasis GO:0006873 168 0.633
metal ion homeostasis GO:0055065 169 0.625
cellular cation homeostasis GO:0030003 163 0.623
modification dependent protein catabolic process GO:0019941 209 0.622
Mouse
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.621
regulation of body fluid levels GO:0050878 99 0.611
regulation of immune response GO:0050776 201 0.605
Mouse
epidermis development GO:0008544 59 0.587
Mouse
hair cycle process GO:0022405 12 0.585
Mouse
positive regulation of proteolysis GO:0045862 142 0.576
Mouse
protein catabolic process GO:0030163 325 0.574
Mouse
negative regulation of interleukin 4 production GO:0032713 3 0.567
vasculature development GO:0001944 181 0.566
Zebrafish Mouse
regulation of establishment of protein localization GO:0070201 242 0.565
negative regulation of protein metabolic process GO:0051248 391 0.561
Mouse
i kappab kinase nf kappab signaling GO:0007249 166 0.559
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.557
Mouse
intermediate filament cytoskeleton organization GO:0045104 17 0.556
positive regulation of cell cycle GO:0045787 140 0.555
small gtpase mediated signal transduction GO:0007264 78 0.551
negative regulation of apoptotic process GO:0043066 316 0.547
cell cell junction organization GO:0045216 69 0.545
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.541
Mouse
positive regulation of cellular catabolic process GO:0031331 284 0.539
Mouse
endocrine system development GO:0035270 26 0.538
nucleoside triphosphate catabolic process GO:0009143 394 0.536
cilium organization GO:0044782 68 0.535
positive regulation of protein transport GO:0051222 135 0.533
regulation of purine nucleotide catabolic process GO:0033121 205 0.528
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 22 0.526
lymphocyte proliferation GO:0046651 70 0.524
ion homeostasis GO:0050801 230 0.523
pituitary gland development GO:0021983 2 0.523
positive regulation of intracellular transport GO:0032388 104 0.521
inorganic cation transmembrane transport GO:0098662 194 0.520
antigen receptor mediated signaling pathway GO:0050851 38 0.520
Mouse
cellular calcium ion homeostasis GO:0006874 117 0.515
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.513
immune system development GO:0002520 195 0.513
Mouse
intermediate filament organization GO:0045109 10 0.510
gland development GO:0048732 48 0.505
Mouse
cell development GO:0048468 328 0.502
Mouse Fly
modification dependent macromolecule catabolic process GO:0043632 212 0.502
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 412 0.495
leukocyte proliferation GO:0070661 74 0.494
segmentation GO:0035282 4 0.489
Mouse
regulation of heart rate by cardiac conduction GO:0086091 19 0.488
molting cycle process GO:0022404 12 0.488
Mouse
protein ubiquitination GO:0016567 314 0.482
Mouse
negative regulation of cell fate specification GO:0009996 3 0.481
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.481
protein localization to organelle GO:0033365 280 0.476
negative regulation of protein modification process GO:0031400 200 0.476
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 392 0.469
coagulation GO:0050817 78 0.468
Mouse
circulatory system process GO:0003013 113 0.467
regulation of cell cycle process GO:0010564 266 0.465
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.463
Mouse
cation homeostasis GO:0055080 189 0.462
protein import GO:0017038 130 0.462
positive regulation of nucleoside metabolic process GO:0045979 186 0.461
regulation of monophenol monooxygenase activity GO:0032771 1 0.459
keratinization GO:0031424 2 0.459
positive regulation of epithelial cell proliferation GO:0050679 65 0.457
regulation of heart contraction GO:0008016 50 0.455
regulation of erbb signaling pathway GO:1901184 27 0.452
Mouse
neural tube formation GO:0001841 3 0.450
nucleoside catabolic process GO:0009164 408 0.448
purine ribonucleotide catabolic process GO:0009154 404 0.444
uterus morphogenesis GO:0061038 2 0.432
regulation of proteasomal protein catabolic process GO:0061136 87 0.431
Mouse
negative regulation of interleukin 5 production GO:0032714 3 0.430
protein stabilization GO:0050821 64 0.430
membrane organization GO:0061024 292 0.428
purine containing compound catabolic process GO:0072523 411 0.426
cytoplasmic transport GO:0016482 379 0.420
single organism membrane organization GO:0044802 268 0.419
positive regulation of immune system process GO:0002684 283 0.418
Mouse
positive regulation of transcription factor import into nucleus GO:0042993 25 0.418
protein homooligomerization GO:0051260 100 0.416
positive regulation of cellular component organization GO:0051130 376 0.416
apoptotic signaling pathway GO:0097190 268 0.414
Mouse
forebrain development GO:0030900 26 0.413
Mouse
regulation of ligase activity GO:0051340 29 0.413
Mouse
neuronal action potential GO:0019228 9 0.411
hair follicle maturation GO:0048820 3 0.410
Mouse
appendage morphogenesis GO:0035107 16 0.408
Mouse
protein import into nucleus GO:0006606 104 0.403
actin filament based process GO:0030029 224 0.400
collateral sprouting GO:0048668 2 0.400
positive regulation of proteoglycan biosynthetic process GO:1902730 3 0.398
t cell proliferation GO:0042098 45 0.396
regulation of carbohydrate metabolic process GO:0006109 54 0.395
hair cycle phase GO:0044851 3 0.392
Mouse
extrinsic apoptotic signaling pathway GO:0097191 119 0.391
positive regulation of cytoplasmic transport GO:1903651 82 0.389
brain development GO:0007420 97 0.388
Zebrafish Mouse
anion transport GO:0006820 161 0.384
Mouse
glycoprotein biosynthetic process GO:0009101 91 0.383
Mouse
intracellular protein transport GO:0006886 270 0.383
negative regulation of type b pancreatic cell apoptotic process GO:2000675 3 0.382
negative regulation of peptidase activity GO:0010466 91 0.382
positive regulation of immune response GO:0050778 159 0.381
Mouse
cellular glucan metabolic process GO:0006073 22 0.379
glycosyl compound catabolic process GO:1901658 413 0.377
regulation of rho protein signal transduction GO:0035023 79 0.377
regulation of cellular component biogenesis GO:0044087 281 0.376
cell cycle arrest GO:0007050 71 0.376
pharynx development GO:0060465 1 0.376
odontogenesis GO:0042476 25 0.373
protein modification by small protein conjugation GO:0032446 342 0.369
Mouse
purine nucleoside triphosphate metabolic process GO:0009144 412 0.369
single organism nuclear import GO:1902593 104 0.368
dorsal ventral pattern formation GO:0009953 15 0.367
Mouse Fly
regulation of cytokine production GO:0001817 232 0.362
neuron differentiation GO:0030182 138 0.362
Mouse Fly
actin crosslink formation GO:0051764 1 0.361
positive regulation of cell proliferation in bone marrow GO:0071864 1 0.359
proteasomal protein catabolic process GO:0010498 176 0.358
Mouse
secondary metabolite biosynthetic process GO:0044550 2 0.357
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.350
positive regulation of protein catabolic process GO:0045732 75 0.348
Mouse
chordate embryonic development GO:0043009 34 0.348
Mouse
columnar cuboidal epithelial cell differentiation GO:0002065 14 0.342
Zebrafish
positive regulation of organelle organization GO:0010638 195 0.341
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.338
Mouse
negative regulation of multicellular organismal process GO:0051241 317 0.335
Mouse
secretion GO:0046903 254 0.334
Mouse
developmental maturation GO:0021700 28 0.332
Mouse
positive regulation of apoptotic process GO:0043065 246 0.331
Mouse
sensory perception GO:0007600 103 0.328
nervous system development GO:0007399 293 0.323
Zebrafish Mouse Fly
ectoderm development GO:0007398 3 0.320
regulation of muscle system process GO:0090257 53 0.320
regulation of neurogenesis GO:0050767 82 0.320
Mouse
dopamine receptor signaling pathway GO:0007212 10 0.319
organ morphogenesis GO:0009887 147 0.316
Mouse
cellular ketone metabolic process GO:0042180 80 0.313
cell junction assembly GO:0034329 67 0.312
gtp catabolic process GO:0006184 237 0.311
immune response activating signal transduction GO:0002757 90 0.311
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.311
negative regulation of catalytic activity GO:0043086 335 0.309
Mouse
regulation of purine nucleotide metabolic process GO:1900542 264 0.309
immune response regulating signaling pathway GO:0002764 97 0.308
Mouse
establishment of protein localization to membrane GO:0090150 121 0.308
maintenance of location in cell GO:0051651 62 0.304
behavioral response to ethanol GO:0048149 2 0.301
cation transport GO:0006812 331 0.300
neuroblast proliferation GO:0007405 4 0.298
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.298
muscle system process GO:0003012 81 0.298
female gamete generation GO:0007292 2 0.296
regulation of cytoskeleton organization GO:0051493 177 0.296
regulation of receptor recycling GO:0001919 10 0.295
Mouse
cerebral cortex cell migration GO:0021795 3 0.294
Mouse
organophosphate catabolic process GO:0046434 430 0.292
gastrulation GO:0007369 51 0.292
amyloid precursor protein metabolic process GO:0042982 17 0.288
Zebrafish Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.287
Mouse
regulation of blood circulation GO:1903522 59 0.286
regulation of protein import into nucleus GO:0042306 78 0.286
regulation of interleukin 5 production GO:0032674 6 0.283
receptor recycling GO:0001881 15 0.282
Mouse
protein oligomerization GO:0051259 173 0.279
negative regulation of hair follicle development GO:0051799 1 0.278
regulation of intracellular transport GO:0032386 195 0.277
negative regulation of hair follicle maturation GO:0048817 1 0.275
regulation of cysteine type endopeptidase activity GO:2000116 127 0.275
peptide metabolic process GO:0006518 51 0.271
Zebrafish Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.270
protein targeting to nucleus GO:0044744 104 0.270
bundle of his cell to purkinje myocyte communication GO:0086069 8 0.267
response to cytokine GO:0034097 232 0.266
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.265
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.264
adult locomotory behavior GO:0008344 1 0.264
regulation of protein processing GO:0070613 150 0.263
Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.259
Mouse
posttranscriptional regulation of gene expression GO:0010608 213 0.258
negative regulation of endopeptidase activity GO:0010951 84 0.257
protein localization to cell surface GO:0034394 28 0.247
muscle tissue development GO:0060537 62 0.246
post embryonic organ development GO:0048569 1 0.245
regulation of nucleocytoplasmic transport GO:0046822 98 0.244
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.243
cellular metal ion homeostasis GO:0006875 146 0.242
embryo development ending in birth or egg hatching GO:0009792 34 0.242
Mouse
ribonucleotide catabolic process GO:0009261 405 0.241
negative regulation of epidermal growth factor activated receptor activity GO:0007175 6 0.238
Mouse
regulation of cell motility GO:2000145 299 0.237
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.237
positive regulation of developmental process GO:0051094 314 0.237
cilium assembly GO:0042384 63 0.237
amyloid precursor protein catabolic process GO:0042987 12 0.236
Zebrafish Mouse
biological phase GO:0044848 5 0.236
Mouse
myeloid leukocyte differentiation GO:0002573 60 0.236
Mouse
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.236
regulation of cytoplasmic transport GO:1903649 149 0.235
multicellular organismal aging GO:0010259 3 0.235
positive regulation of secondary metabolite biosynthetic process GO:1900378 1 0.234
leukocyte activation GO:0045321 164 0.234
Mouse
regulation of nucleoside metabolic process GO:0009118 209 0.234
tube development GO:0035295 125 0.233
Mouse
regulation of cellular protein catabolic process GO:1903362 96 0.233
Mouse
nucleoside triphosphate metabolic process GO:0009141 422 0.233
pigmentation GO:0043473 22 0.232
Zebrafish
specification of organ identity GO:0010092 3 0.232
ribonucleoside catabolic process GO:0042454 406 0.231
regulation of actin filament based movement GO:1903115 24 0.229
lung alveolus development GO:0048286 4 0.228
muscle tissue morphogenesis GO:0060415 19 0.224
regulation of system process GO:0044057 101 0.222
purine nucleoside catabolic process GO:0006152 398 0.221
circulatory system development GO:0072359 262 0.221
Zebrafish Mouse
muscle cell proliferation GO:0033002 35 0.218
regulation of rho gtpase activity GO:0032319 66 0.215
embryonic epithelial tube formation GO:0001838 4 0.210
positive regulation of cell cycle process GO:0090068 106 0.208
cell substrate adhesion GO:0031589 132 0.206
cardiac conduction GO:0061337 23 0.206
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.205
gastrulation with mouth forming second GO:0001702 1 0.204
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 20 0.202
Mouse
negative regulation of catabolic process GO:0009895 104 0.202
Mouse
sulfur compound metabolic process GO:0006790 101 0.200
purine ribonucleoside catabolic process GO:0046130 398 0.198
transmembrane transport GO:0055085 399 0.198
activation of immune response GO:0002253 114 0.196
Mouse
positive regulation of cell division GO:0051781 59 0.195
regulation of growth GO:0040008 165 0.195
regulation of neuron migration GO:2001222 3 0.193
somite development GO:0061053 7 0.192
Zebrafish Mouse
cellular amine metabolic process GO:0044106 41 0.192
ion transmembrane transport GO:0034220 338 0.192
embryonic forelimb morphogenesis GO:0035115 4 0.191
striated muscle tissue development GO:0014706 59 0.190
blood coagulation GO:0007596 76 0.190
cell fate specification GO:0001708 8 0.189
Mouse
digestive tract development GO:0048565 75 0.189
purine ribonucleoside metabolic process GO:0046128 437 0.188
epithelial cell differentiation GO:0030855 141 0.187
Zebrafish
regulation of intracellular protein transport GO:0033157 123 0.187
positive regulation of cell motility GO:2000147 177 0.187
anatomical structure formation involved in morphogenesis GO:0048646 284 0.186
Mouse
adenylate cyclase inhibiting dopamine receptor signaling pathway GO:0007195 4 0.186
nucleoside monophosphate metabolic process GO:0009123 191 0.185
visual behavior GO:0007632 2 0.185
embryonic limb morphogenesis GO:0030326 9 0.185
Mouse
negative regulation of protein transport GO:0051224 75 0.184
regulation of protein complex assembly GO:0043254 147 0.183
cell morphogenesis GO:0000902 296 0.181
Mouse Fly
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 3 0.181
response to radiation GO:0009314 151 0.180
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.176
Mouse
muscle structure development GO:0061061 98 0.175
cellular macromolecule catabolic process GO:0044265 380 0.175
Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.175
lipoprotein particle mediated signaling GO:0055095 1 0.174
anatomical structure maturation GO:0071695 9 0.174
Mouse
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.174
Mouse
mesenchyme development GO:0060485 59 0.174
cognition GO:0050890 43 0.173
Mouse
negative regulation of hydrolase activity GO:0051346 182 0.173
hemopoiesis GO:0030097 180 0.172
Mouse
nuclear transport GO:0051169 179 0.172
covalent chromatin modification GO:0016569 254 0.171
oogenesis GO:0048477 2 0.171
epidermal cell differentiation GO:0009913 45 0.169
cardiac cell fate specification GO:0060912 1 0.169
regulation of transcription factor import into nucleus GO:0042990 39 0.166
negative regulation of protein binding GO:0032091 35 0.166
protein targeting GO:0006605 187 0.166
establishment of protein localization to plasma membrane GO:0090002 68 0.164
immune response GO:0006955 307 0.164
Mouse
positive regulation of melanosome transport GO:1902910 1 0.162
mitotic cell cycle process GO:1903047 286 0.161
cellular amino acid metabolic process GO:0006520 116 0.160
regulation of epidermal growth factor activated receptor activity GO:0007176 14 0.159
Mouse
developmental pigmentation GO:0048066 12 0.159
Zebrafish
ventricular cardiac muscle tissue morphogenesis GO:0055010 14 0.159
positive regulation of protein localization to nucleus GO:1900182 48 0.158
peptidyl tyrosine phosphorylation GO:0018108 170 0.158
Mouse
regulation of nucleotide metabolic process GO:0006140 269 0.158
regulation of sulfur metabolic process GO:0042762 5 0.157
nucleoside phosphate catabolic process GO:1901292 412 0.155
nucleocytoplasmic transport GO:0006913 176 0.155
regulation of vesicle mediated transport GO:0060627 130 0.155
lung associated mesenchyme development GO:0060484 1 0.154
regulation of determination of dorsal identity GO:2000015 2 0.154
heparan sulfate proteoglycan metabolic process GO:0030201 12 0.154
regulation of glial cell differentiation GO:0045685 3 0.154
response to abiotic stimulus GO:0009628 336 0.154
regulation of nucleotide catabolic process GO:0030811 205 0.154
regulation of catagen GO:0051794 3 0.153
synaptic vesicle endocytosis GO:0048488 2 0.152
epithelial cell morphogenesis GO:0003382 8 0.150
regulation of epithelial cell differentiation involved in kidney development GO:2000696 4 0.149
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.149
Mouse
response to lithium ion GO:0010226 2 0.148
negative regulation of gliogenesis GO:0014014 3 0.148
regulation of protein targeting GO:1903533 91 0.148
ventricular cardiac muscle tissue development GO:0003229 14 0.147
nuclear import GO:0051170 106 0.146
neuron projection development GO:0031175 106 0.145
Mouse Fly
limb morphogenesis GO:0035108 16 0.145
Mouse
nephron tubule epithelial cell differentiation GO:0072160 3 0.144
negative regulation of neurogenesis GO:0050768 26 0.144
Mouse
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.143
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 3 0.143
microtubule cytoskeleton organization GO:0000226 176 0.140
ras protein signal transduction GO:0007265 73 0.139
regulation of muscle contraction GO:0006937 45 0.138
chromatin modification GO:0016568 298 0.138
mitotic cell cycle GO:0000278 326 0.136
positive regulation of nucleotide catabolic process GO:0030813 185 0.136
purine nucleotide catabolic process GO:0006195 405 0.135
positive regulation of cellular component movement GO:0051272 181 0.134
cellular response to nutrient levels GO:0031669 69 0.134
Mouse
tube morphogenesis GO:0035239 95 0.134
Mouse
positive regulation of peptidase activity GO:0010952 88 0.134
positive regulation of rho gtpase activity GO:0032321 56 0.133
hair follicle morphogenesis GO:0031069 2 0.133
regulation of neuroblast proliferation GO:1902692 3 0.132
secretion by cell GO:0032940 226 0.132
Mouse
cilium morphogenesis GO:0060271 75 0.132
regulation of epithelial cell proliferation GO:0050678 113 0.132
negative regulation of transforming growth factor beta2 production GO:0032912 2 0.132
actin cytoskeleton organization GO:0030036 207 0.132
regulation of multi organism process GO:0043900 157 0.131
regulation of protein stability GO:0031647 87 0.131
cytokinesis GO:0000910 96 0.131
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.130
Mouse
cerebral cortex radial glia guided migration GO:0021801 1 0.130
morphogenesis of embryonic epithelium GO:0016331 4 0.130
growth GO:0040007 202 0.130
locomotory behavior GO:0007626 1 0.130
Zebrafish

PSEN1 disease predictions

Disease DO term ID Size Probability Func Analog Org
dementia DOID:1307 19 1.000
alzheimer s disease DOID:10652 16 1.000
central nervous system disease DOID:331 186 1.000
disease of mental health DOID:150 70 1.000
tauopathy DOID:680 16 1.000
neurodegenerative disease DOID:1289 102 1.000
nervous system disease DOID:863 431 1.000
cognitive disorder DOID:1561 29 1.000
heart disease DOID:114 68 0.988
cardiovascular system disease DOID:1287 106 0.988
musculoskeletal system disease DOID:17 223 0.951
muscular disease DOID:0080000 114 0.766
bone development disease DOID:0080006 55 0.688
bone disease DOID:0080001 88 0.688
connective tissue disease DOID:65 109 0.688
disease of metabolism DOID:0014667 295 0.648
myopathy DOID:423 104 0.636
cardiomyopathy DOID:0050700 50 0.636
muscle tissue disease DOID:66 113 0.636
dilated cardiomyopathy DOID:12930 32 0.548
intrinsic cardiomyopathy DOID:0060036 50 0.548
acquired metabolic disease DOID:0060158 58 0.504
skin disease DOID:37 33 0.308
integumentary system disease DOID:16 43 0.308
diabetes mellitus DOID:9351 31 0.251
carbohydrate metabolism disease DOID:0050013 32 0.251
glucose metabolism disease DOID:4194 32 0.251