Homo sapiens

40 known processes

PSEN2

presenilin 2 (Alzheimer disease 4)

(Aliases: CMD1V,PS2,AD3L,STM2,AD4)

PSEN2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
calcium ion transmembrane transport GO:0070588 76 0.997
Human
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 3 0.983
Mouse
cation transmembrane transport GO:0098655 238 0.957
Human
amyloid precursor protein catabolic process GO:0042987 12 0.905
brain morphogenesis GO:0048854 1 0.903
Mouse
regulation of protein localization to plasma membrane GO:1903076 40 0.884
single organism cell adhesion GO:0098602 179 0.865
Human
negative regulation of cell death GO:0060548 345 0.855
Human Mouse
single organism membrane organization GO:0044802 268 0.845
platelet formation GO:0030220 4 0.841
positive regulation of protein targeting to membrane GO:0090314 8 0.829
positive regulation of transport GO:0051050 336 0.826
cellular calcium ion homeostasis GO:0006874 117 0.815
Human Mouse
platelet morphogenesis GO:0036344 4 0.798
cell adhesion GO:0007155 325 0.790
Human
negative regulation of megakaryocyte differentiation GO:0045653 16 0.780
negative regulation of phosphate metabolic process GO:0045936 267 0.776
Mouse
cellular amine metabolic process GO:0044106 41 0.775
inorganic cation transmembrane transport GO:0098662 194 0.744
Human
notch receptor processing GO:0007220 2 0.744
cellular response to dna damage stimulus GO:0006974 379 0.732
hair follicle maturation GO:0048820 3 0.723
Mouse
divalent metal ion transport GO:0070838 152 0.711
Human Mouse
regulation of establishment of protein localization GO:0070201 242 0.704
membrane organization GO:0061024 292 0.692
positive regulation of cellular component organization GO:0051130 376 0.690
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.689
ion transmembrane transport GO:0034220 338 0.684
Human
inorganic ion transmembrane transport GO:0098660 231 0.679
Human
single organism cellular localization GO:1902580 332 0.675
cardiovascular system development GO:0072358 262 0.673
positive regulation of intracellular transport GO:0032388 104 0.659
striated muscle contraction GO:0006941 52 0.659
Mouse
negative regulation of phosphorylation GO:0042326 174 0.630
Mouse
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 43 0.618
cellular metal ion homeostasis GO:0006875 146 0.617
Human Mouse
regulation of cellular amino acid metabolic process GO:0006521 6 0.608
cellular divalent inorganic cation homeostasis GO:0072503 128 0.607
Human Mouse
biological adhesion GO:0022610 331 0.606
Human
cellular response to nerve growth factor stimulus GO:1990090 6 0.592
protein localization to membrane GO:0072657 160 0.587
regulation of protein serine threonine kinase activity GO:0071900 179 0.586
amine metabolic process GO:0009308 44 0.582
associative learning GO:0008306 1 0.577
hematopoietic progenitor cell differentiation GO:0002244 38 0.575
Mouse
mapk cascade GO:0000165 288 0.572
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.555
positive regulation of phosphorylation GO:0042327 394 0.552
signal transduction by phosphorylation GO:0023014 297 0.546
regulation of protein localization GO:0032880 296 0.545
beta amyloid formation GO:0034205 7 0.541
cation homeostasis GO:0055080 189 0.538
Human Mouse
negative regulation of protein metabolic process GO:0051248 391 0.536
Mouse
regulation of microtubule based process GO:0032886 74 0.523
regulation of metalloenzyme activity GO:0048552 3 0.519
negative regulation of protein phosphorylation GO:0001933 140 0.517
Mouse
cation transport GO:0006812 331 0.500
Human Mouse
spermatid development GO:0007286 4 0.500
regulation of protein targeting GO:1903533 91 0.492
negative regulation of cellular component organization GO:0051129 235 0.489
Mouse
myeloid dendritic cell differentiation GO:0043011 3 0.480
regulation of protein catabolic process GO:0042176 155 0.479
Mouse
protein modification by small protein conjugation GO:0032446 342 0.475
Mouse
cell substrate adhesion GO:0031589 132 0.462
regulation of intracellular protein transport GO:0033157 123 0.461
metal ion homeostasis GO:0055065 169 0.457
Human Mouse
positive regulation of secretion GO:0051047 116 0.451
positive regulation of secretion by cell GO:1903532 108 0.449
blood vessel morphogenesis GO:0048514 162 0.443
regulation of cell adhesion GO:0030155 166 0.432
cellular component morphogenesis GO:0032989 314 0.431
positive regulation of cell differentiation GO:0045597 211 0.429
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.418
chemokine mediated signaling pathway GO:0070098 16 0.417
hematopoietic or lymphoid organ development GO:0048534 186 0.414
Mouse
regulation of megakaryocyte differentiation GO:0045652 22 0.411
substrate adhesion dependent cell spreading GO:0034446 41 0.410
negative regulation of developmental process GO:0051093 247 0.410
regulation of binding GO:0051098 111 0.410
Mouse
ion homeostasis GO:0050801 230 0.408
Human Mouse
positive regulation of blood vessel endothelial cell migration GO:0043536 16 0.402
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.392
Mouse
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.391
positive regulation of cytosolic calcium ion concentration GO:0007204 82 0.390
negative regulation of apoptotic signaling pathway GO:2001234 97 0.387
Mouse
cerebral cortex neuron differentiation GO:0021895 1 0.386
positive regulation of proteolysis GO:0045862 142 0.385
Mouse
cellular response to endogenous stimulus GO:0071495 336 0.384
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.383
regulation of microtubule cytoskeleton organization GO:0070507 61 0.381
regulation of mapk cascade GO:0043408 262 0.380
positive regulation of organelle organization GO:0010638 195 0.373
regulation of growth GO:0040008 165 0.371
protein localization to plasma membrane GO:0072659 93 0.371
regulation of cell migration involved in sprouting angiogenesis GO:0090049 9 0.364
microtubule cytoskeleton organization GO:0000226 176 0.363
positive regulation of cell death GO:0010942 263 0.361
Mouse
vasculature development GO:0001944 181 0.359
regulation of cell differentiation GO:0045595 393 0.354
sequestering of calcium ion GO:0051208 17 0.350
positive regulation of kinase activity GO:0033674 204 0.350
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.350
thymus development GO:0048538 3 0.349
Mouse
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.347
establishment of protein localization to plasma membrane GO:0090002 68 0.344
nitrogen compound transport GO:0071705 191 0.338
cellular homeostasis GO:0019725 196 0.337
Human Mouse
memory GO:0007613 3 0.333
Mouse
negative regulation of neurogenesis GO:0050768 26 0.333
protein ubiquitination GO:0016567 314 0.332
Mouse
peptide secretion GO:0002790 51 0.331
regulation of cell growth GO:0001558 135 0.330
cardiac muscle cell contraction GO:0086003 4 0.327
negative regulation of protein modification process GO:0031400 200 0.324
Mouse
actin filament based process GO:0030029 224 0.321
regulation of intracellular transport GO:0032386 195 0.321
negative regulation of neuron differentiation GO:0045665 21 0.316
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.313
anatomical structure formation involved in morphogenesis GO:0048646 284 0.310
Mouse
peptidyl tyrosine modification GO:0018212 170 0.308
Mouse
spermatid differentiation GO:0048515 4 0.307
plasma membrane organization GO:0007009 115 0.305
regulation of protein transport GO:0051223 213 0.304
posttranscriptional regulation of gene expression GO:0010608 213 0.304
positive regulation of mapk cascade GO:0043410 190 0.304
positive regulation of calcium ion transport into cytosol GO:0010524 20 0.300
positive regulation of transferase activity GO:0051347 227 0.298
positive regulation of angiogenesis GO:0045766 51 0.294
regulation of insulin secretion GO:0050796 33 0.293
positive regulation of cell adhesion mediated by integrin GO:0033630 9 0.292
positive regulation of intracellular protein transport GO:0090316 76 0.292
calcium mediated signaling GO:0019722 44 0.288
peptidyl tyrosine phosphorylation GO:0018108 170 0.286
Mouse
cellular amino acid metabolic process GO:0006520 116 0.285
synaptic vesicle exocytosis GO:0016079 3 0.279
negative regulation of cytoskeleton organization GO:0051494 45 0.278
positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 3 0.277
protein targeting GO:0006605 187 0.274
regulation of hematopoietic progenitor cell differentiation GO:1901532 24 0.269
regulation of homeostatic process GO:0032844 121 0.268
muscle system process GO:0003012 81 0.267
Mouse
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.267
Mouse
regulation of apoptotic signaling pathway GO:2001233 175 0.266
Mouse
negative regulation of ubiquitin protein transferase activity GO:0051444 8 0.265
Mouse
sequestering of metal ion GO:0051238 24 0.264
blood vessel endothelial cell migration GO:0043534 42 0.262
blood vessel development GO:0001568 172 0.262
amyloid precursor protein metabolic process GO:0042982 17 0.261
positive regulation of protein phosphorylation GO:0001934 313 0.261
regulation of proteasomal protein catabolic process GO:0061136 87 0.260
Mouse
copper ion import GO:0015677 1 0.258
positive regulation of establishment of protein localization to plasma membrane GO:0090004 18 0.258
single organismal cell cell adhesion GO:0016337 148 0.258
Human
motor neuron axon guidance GO:0008045 2 0.256
regulation of cell morphogenesis GO:0022604 153 0.253
beta amyloid metabolic process GO:0050435 12 0.252
Mouse
microtubule depolymerization GO:0007019 18 0.249
negative regulation of cell projection organization GO:0031345 22 0.247
regulation of peptide hormone secretion GO:0090276 41 0.247
signal release GO:0023061 70 0.244
regulation of purine nucleotide metabolic process GO:1900542 264 0.243
sprouting angiogenesis GO:0002040 29 0.242
positive regulation of endothelial cell migration GO:0010595 39 0.239
transmembrane transport GO:0055085 399 0.238
Human
circulatory system development GO:0072359 262 0.236
protein maturation GO:0051604 233 0.235
ubiquitin dependent protein catabolic process GO:0006511 206 0.232
Mouse
negative regulation of multicellular organismal process GO:0051241 317 0.232
growth GO:0040007 202 0.229
protein import GO:0017038 130 0.226
mitochondrion organization GO:0007005 156 0.226
regulation of transcription factor import into nucleus GO:0042990 39 0.224
protein catabolic process GO:0030163 325 0.224
Mouse
negative regulation of intracellular signal transduction GO:1902532 183 0.222
negative regulation of neuron projection development GO:0010977 15 0.219
regulation of blood vessel endothelial cell migration GO:0043535 30 0.218
membrane protein proteolysis GO:0033619 38 0.216
cell development GO:0048468 328 0.215
regulation of vasculature development GO:1901342 97 0.214
regulation of cellular component biogenesis GO:0044087 281 0.214
Mouse
mitotic cell cycle GO:0000278 326 0.212
regulation of cardiac muscle contraction GO:0055117 33 0.211
negative regulation of axonogenesis GO:0050771 4 0.208
intracellular protein transport GO:0006886 270 0.207
regulation of transferase activity GO:0051338 355 0.207
Mouse
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.199
g protein coupled receptor signaling pathway GO:0007186 207 0.196
negative regulation of programmed cell death GO:0043069 321 0.196
Human Mouse
neuron projection development GO:0031175 106 0.195
second messenger mediated signaling GO:0019932 78 0.195
modification dependent macromolecule catabolic process GO:0043632 212 0.193
Mouse
negative regulation of cellular protein metabolic process GO:0032269 353 0.191
Mouse
coagulation GO:0050817 78 0.191
Mouse
cellular response to starvation GO:0009267 58 0.191
cerebral cortex cell migration GO:0021795 3 0.191
visual learning GO:0008542 1 0.190
positive regulation of catabolic process GO:0009896 310 0.188
Mouse
positive regulation of cell motility GO:2000147 177 0.183
inositol phosphate mediated signaling GO:0048016 16 0.183
positive regulation of protein localization to plasma membrane GO:1903078 20 0.181
positive regulation of protein transport GO:0051222 135 0.181
establishment of protein localization to membrane GO:0090150 121 0.181
protein complex disassembly GO:0043241 52 0.180
regulation of myeloid cell differentiation GO:0045637 81 0.180
immune system development GO:0002520 195 0.179
Mouse
protein glycosylation GO:0006486 62 0.178
anion transport GO:0006820 161 0.178
cell activation involved in immune response GO:0002263 30 0.178
Mouse
cytoplasmic sequestering of protein GO:0051220 12 0.178
cilium organization GO:0044782 68 0.177
negative regulation of cell differentiation GO:0045596 171 0.177
secretion by cell GO:0032940 226 0.177
actin crosslink formation GO:0051764 1 0.177
regulation of peptidase activity GO:0052547 180 0.177
cell growth GO:0016049 160 0.175
post embryonic development GO:0009791 2 0.174
glycosylation GO:0070085 71 0.174
regulation of transporter activity GO:0032409 82 0.173
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.173
Mouse
cell communication by electrical coupling involved in cardiac conduction GO:0086064 3 0.168
angiogenesis GO:0001525 147 0.168
positive regulation of protein kinase activity GO:0045860 190 0.167
l glutamate transport GO:0015813 6 0.167
negative regulation of apoptotic process GO:0043066 316 0.167
Human Mouse
regulation of cellular component movement GO:0051270 334 0.166
megakaryocyte differentiation GO:0030219 25 0.166
regulation of multi organism process GO:0043900 157 0.166
regulation of neurogenesis GO:0050767 82 0.165
cell matrix adhesion GO:0007160 85 0.165
transcription factor import into nucleus GO:0042991 40 0.165
positive regulation of metalloenzyme activity GO:0048554 2 0.164
regulation of anatomical structure morphogenesis GO:0022603 286 0.163
enzyme linked receptor protein signaling pathway GO:0007167 303 0.160
Mouse
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.159
positive regulation of protein catabolic process GO:0045732 75 0.159
Mouse
cell morphogenesis GO:0000902 296 0.158
regulation of hormone levels GO:0010817 125 0.157
positive regulation of substrate adhesion dependent cell spreading GO:1900026 15 0.156
negative regulation of phosphorus metabolic process GO:0010563 267 0.156
Mouse
release of sequestered calcium ion into cytosol GO:0051209 41 0.156
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.154
Mouse
regulation of protein ubiquitination GO:0031396 95 0.154
Mouse
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.154
positive regulation of cell substrate adhesion GO:0010811 37 0.153
negative regulation of nervous system development GO:0051961 28 0.153
positive regulation of cellular catabolic process GO:0031331 284 0.152
Mouse
regulation of cytoskeleton organization GO:0051493 177 0.151
hemostasis GO:0007599 76 0.150
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.149
Mouse
apoptotic mitochondrial changes GO:0008637 57 0.149
positive regulation of ion transport GO:0043270 87 0.147
cellular macromolecule catabolic process GO:0044265 380 0.146
Mouse
microtubule polymerization or depolymerization GO:0031109 37 0.146
actin mediated cell contraction GO:0070252 12 0.146
ameboidal type cell migration GO:0001667 135 0.144
positive regulation of reproductive process GO:2000243 9 0.144
modification dependent protein catabolic process GO:0019941 209 0.143
Mouse
positive regulation of cell proliferation GO:0008284 301 0.142
regulation of cell projection organization GO:0031344 107 0.140
regulation of synaptic plasticity GO:0048167 3 0.140
Mouse
regulation of protein binding GO:0043393 66 0.139
Mouse
cellular response to tumor necrosis factor GO:0071356 63 0.138
actin filament based movement GO:0030048 17 0.137
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.137
Mouse
myeloid cell differentiation GO:0030099 117 0.137
Mouse
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 18 0.137
somitogenesis GO:0001756 2 0.136
Mouse
organic acid transport GO:0015849 65 0.136
negative regulation of myeloid cell differentiation GO:0045638 42 0.136
cytosolic calcium ion homeostasis GO:0051480 89 0.134
amide transport GO:0042886 76 0.132
positive regulation of hormone secretion GO:0046887 25 0.131
negative regulation of homeostatic process GO:0032845 59 0.131
cellular response to cytokine stimulus GO:0071345 181 0.130
regulation of calcium ion transport into cytosol GO:0010522 33 0.127
cellular amide metabolic process GO:0043603 69 0.127
Mouse
cellular macromolecular complex assembly GO:0034622 324 0.127
negative regulation of microtubule depolymerization GO:0007026 12 0.127
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.126
Mouse
organelle assembly GO:0070925 176 0.125
response to tumor necrosis factor GO:0034612 76 0.125
positive regulation of programmed cell death GO:0043068 249 0.123
Mouse
maintenance of location in cell GO:0051651 62 0.123
intrinsic apoptotic signaling pathway GO:0097193 127 0.122
hormone secretion GO:0046879 65 0.122
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.122
Mouse
single organism carbohydrate metabolic process GO:0044723 193 0.121
negative regulation of binding GO:0051100 57 0.120
Mouse
protein depolymerization GO:0051261 30 0.118
epithelium migration GO:0090132 119 0.118
ribonucleoside monophosphate metabolic process GO:0009161 187 0.117
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.117
Mouse
immune response GO:0006955 307 0.117
Mouse
leukocyte activation involved in immune response GO:0002366 30 0.116
Mouse
mitochondrial transport GO:0006839 60 0.115
hemopoiesis GO:0030097 180 0.114
Mouse
regulation of cell adhesion mediated by integrin GO:0033628 22 0.114
positive regulation of release of sequestered calcium ion into cytosol GO:0051281 16 0.113
positive regulation of epithelial cell migration GO:0010634 55 0.112
positive regulation of multi organism process GO:0043902 56 0.112
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.112
Mouse
chemical homeostasis GO:0048878 306 0.112
Human Mouse
carbohydrate derivative biosynthetic process GO:1901137 207 0.110
regulation of calcium mediated signaling GO:0050848 17 0.109
negative regulation of organelle organization GO:0010639 126 0.109
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.109
Mouse
cytokine mediated signaling pathway GO:0019221 109 0.107
regulation of proteolysis GO:0030162 293 0.107
Mouse
secretion GO:0046903 254 0.107
microtubule based process GO:0007017 210 0.105
regulation of protein oligomerization GO:0032459 26 0.104
negative regulation of protein transport GO:0051224 75 0.104
regulation of establishment of protein localization to plasma membrane GO:0090003 30 0.102
regulation of endothelial cell migration GO:0010594 67 0.100
positive regulation of cell development GO:0010720 92 0.100
cell morphogenesis involved in differentiation GO:0000904 144 0.099
negative regulation of cell development GO:0010721 48 0.099
cell projection organization GO:0030030 252 0.098
cell activation GO:0001775 213 0.098
Mouse
regulation of neuron projection development GO:0010975 57 0.097
divalent inorganic cation transport GO:0072511 158 0.097
Human Mouse
protein processing GO:0016485 226 0.097
cell cell signaling GO:0007267 155 0.097
Mouse
organ formation GO:0048645 3 0.097
immune response regulating signaling pathway GO:0002764 97 0.097
Mouse
cell migration involved in sprouting angiogenesis GO:0002042 19 0.097
carbohydrate metabolic process GO:0005975 207 0.096
oxidation reduction process GO:0055114 396 0.096
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.095
positive regulation of calcium ion transport GO:0051928 51 0.095
cellular response to oxygen containing compound GO:1901701 276 0.094
locomotory behavior GO:0007626 1 0.092
positive regulation of cellular amine metabolic process GO:0033240 7 0.091
positive regulation of hydrolase activity GO:0051345 331 0.091
positive regulation of apoptotic signaling pathway GO:2001235 70 0.090
Mouse
protein localization to organelle GO:0033365 280 0.090
regulation of ion homeostasis GO:2000021 73 0.090
regulation of angiogenesis GO:0045765 92 0.088
regulation of cardiac muscle cell contraction GO:0086004 23 0.088
blood circulation GO:0008015 113 0.087
Mouse
regulation of receptor recycling GO:0001919 10 0.087
Mouse
cell cell signaling involved in cell fate commitment GO:0045168 5 0.086
positive regulation of calcineurin nfat signaling cascade GO:0070886 4 0.086
regulation of relaxation of muscle GO:1901077 3 0.086
regulation of protein import into nucleus GO:0042306 78 0.086
cell adhesion mediated by integrin GO:0033627 27 0.085
response to nerve growth factor GO:1990089 6 0.085
uterus morphogenesis GO:0061038 2 0.084
peptide transport GO:0015833 74 0.084
regulation of substrate adhesion dependent cell spreading GO:1900024 19 0.084
regulation of cellular protein catabolic process GO:1903362 96 0.083
Mouse
metal ion transport GO:0030001 272 0.083
Human Mouse
negative regulation of ion transport GO:0043271 39 0.083
regulation of transmembrane transporter activity GO:0022898 74 0.083
organic hydroxy compound transport GO:0015850 63 0.083
regulation of cellular amine metabolic process GO:0033238 11 0.082
positive regulation of apoptotic process GO:0043065 246 0.082
Mouse
generation of neurons GO:0048699 152 0.082
carboxylic acid transport GO:0046942 63 0.081
negative regulation of transport GO:0051051 176 0.081
macroautophagy GO:0016236 39 0.081
negative regulation of protein complex disassembly GO:0043242 20 0.080
negative regulation of sequestering of calcium ion GO:0051283 41 0.079
defense response GO:0006952 315 0.079
visual behavior GO:0007632 2 0.079
regulation of collagen catabolic process GO:0010710 3 0.079
regulation of cell substrate adhesion GO:0010810 68 0.078
regulation of striated muscle contraction GO:0006942 37 0.077
behavioral response to ethanol GO:0048149 2 0.077
proteasomal protein catabolic process GO:0010498 176 0.077
Mouse
immune response activating signal transduction GO:0002757 90 0.077
Mouse
receptor metabolic process GO:0043112 81 0.076
Mouse
regulation of protein depolymerization GO:1901879 22 0.076
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.074
lymphangiogenesis GO:0001946 7 0.074
regulation of secretion GO:0051046 194 0.073
cellular component assembly involved in morphogenesis GO:0010927 73 0.073
neuron development GO:0048666 113 0.073
glycoprotein metabolic process GO:0009100 110 0.072
hair cycle phase GO:0044851 3 0.072
Mouse
protein import into nucleus GO:0006606 104 0.072
positive regulation of homeostatic process GO:0032846 47 0.072
appendage morphogenesis GO:0035107 16 0.072
Mouse
purine nucleoside triphosphate catabolic process GO:0009146 392 0.071
cellular component disassembly GO:0022411 92 0.071
regulation of cysteine type endopeptidase activity GO:2000116 127 0.071
multicellular organismal aging GO:0010259 3 0.071
cytosolic calcium ion transport GO:0060401 48 0.070
response to light stimulus GO:0009416 87 0.070
regulation of muscle contraction GO:0006937 45 0.070
single organism reproductive process GO:0044702 98 0.070
dopamine receptor signaling pathway GO:0007212 10 0.069
regulation of ion transport GO:0043269 189 0.069
female gamete generation GO:0007292 2 0.069
cellular cation homeostasis GO:0030003 163 0.069
Human Mouse
regulation of nervous system development GO:0051960 88 0.068
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.068
negative regulation of catabolic process GO:0009895 104 0.068
Mouse
negative regulation of cell proliferation GO:0008285 228 0.067
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.067
atp catabolic process GO:0006200 157 0.067
protein stabilization GO:0050821 64 0.067
regulation of calcium ion transmembrane transporter activity GO:1901019 28 0.066
ectoderm development GO:0007398 3 0.066
regulation of cell motility GO:2000145 299 0.066
response to radiation GO:0009314 151 0.066
regulation of cell cycle process GO:0010564 266 0.065
glucose homeostasis GO:0042593 31 0.065
dephosphorylation GO:0016311 209 0.065
response to oxidative stress GO:0006979 121 0.065
regulation of microtubule depolymerization GO:0031114 12 0.064
positive regulation of cellular component movement GO:0051272 181 0.064
regulation of release of sequestered calcium ion into cytosol GO:0051279 27 0.063
cellular ketone metabolic process GO:0042180 80 0.063
neurogenesis GO:0022008 169 0.062
Zebrafish
single organism nuclear import GO:1902593 104 0.062
negative regulation of protein kinase b signaling GO:0051898 17 0.062
macromolecule glycosylation GO:0043413 63 0.062
positive regulation of developmental process GO:0051094 314 0.062
negative regulation of peptidyl tyrosine phosphorylation GO:0050732 20 0.062
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.061
Mouse
calcium ion transport GO:0006816 147 0.061
Human Mouse
negative regulation of hydrolase activity GO:0051346 182 0.061
amino acid transport GO:0006865 28 0.061
regulation of peptide transport GO:0090087 62 0.061
cilium morphogenesis GO:0060271 75 0.060
maintenance of protein location in cell GO:0032507 56 0.060
reproductive process GO:0022414 106 0.060
cytoplasmic transport GO:0016482 379 0.060
cellular extravasation GO:0045123 21 0.059
regulation of ligase activity GO:0051340 29 0.059
Mouse
neuron differentiation GO:0030182 138 0.059
negative regulation of protein binding GO:0032091 35 0.058
Mouse
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.058
regulation of release of cytochrome c from mitochondria GO:0090199 29 0.058
epidermis development GO:0008544 59 0.058
Mouse
endosomal transport GO:0016197 129 0.057
regulation of protein localization to nucleus GO:1900180 85 0.057
positive regulation of cellular component biogenesis GO:0044089 158 0.057
nuclear import GO:0051170 106 0.057
hormone transport GO:0009914 68 0.056
macromolecular complex disassembly GO:0032984 60 0.055
regulation of secretion by cell GO:1903530 177 0.055
ribonucleotide catabolic process GO:0009261 405 0.055
negative regulation of ion transmembrane transport GO:0034766 26 0.055
insulin secretion GO:0030073 39 0.055
negative regulation of transferase activity GO:0051348 124 0.055
Mouse
carbohydrate homeostasis GO:0033500 31 0.055
regulation of neuron differentiation GO:0045664 70 0.055
regulation of endopeptidase activity GO:0052548 170 0.054
cilium assembly GO:0042384 63 0.054
cellular ion homeostasis GO:0006873 168 0.054
Human Mouse
pattern specification process GO:0007389 43 0.054
Mouse
response to hypoxia GO:0001666 96 0.054
cellular protein complex disassembly GO:0043624 36 0.053
protein targeting to nucleus GO:0044744 104 0.052
maintenance of location GO:0051235 112 0.052
negative regulation of protein depolymerization GO:1901880 17 0.052
regulation of ubiquitin protein transferase activity GO:0051438 28 0.052
Mouse
response to cytokine GO:0034097 232 0.051
regulation of erk1 and erk2 cascade GO:0070372 99 0.051
transition metal ion transport GO:0000041 23 0.051
segmentation GO:0035282 4 0.051
Mouse
ribonucleoside catabolic process GO:0042454 406 0.051
regulation of calcium ion transmembrane transport GO:1903169 28 0.050
calcium ion transport into cytosol GO:0060402 48 0.050
regulation of kinase activity GO:0043549 314 0.050
Mouse
positive regulation of cell matrix adhesion GO:0001954 23 0.050
acidic amino acid transport GO:0015800 6 0.049
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 22 0.049
negative regulation of immune system process GO:0002683 136 0.049

PSEN2 disease predictions

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system disease DOID:17 223 0.899
myopathy DOID:423 104 0.830
muscular disease DOID:0080000 114 0.830
heart disease DOID:114 68 0.830
cardiomyopathy DOID:0050700 50 0.830
dilated cardiomyopathy DOID:12930 32 0.830
intrinsic cardiomyopathy DOID:0060036 50 0.830
cardiovascular system disease DOID:1287 106 0.830
muscle tissue disease DOID:66 113 0.830
disease of mental health DOID:150 70 0.751
cognitive disorder DOID:1561 29 0.751
central nervous system disease DOID:331 186 0.750
tauopathy DOID:680 16 0.750
neurodegenerative disease DOID:1289 102 0.750
nervous system disease DOID:863 431 0.750
dementia DOID:1307 19 0.548
skin disease DOID:37 33 0.278
Human
integumentary system disease DOID:16 43 0.278
Human
bone development disease DOID:0080006 55 0.260
bone disease DOID:0080001 88 0.260
connective tissue disease DOID:65 109 0.260
brain disease DOID:936 73 0.133
Human
alzheimer s disease DOID:10652 16 0.054