Homo sapiens

28 known processes

PSENEN

presenilin enhancer 2 homolog (C. elegans)

(Aliases: MSTP064,PEN-2,PEN2)

PSENEN biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
notch receptor processing GO:0007220 2 0.224
Mouse
post embryonic development GO:0009791 2 0.139
protein maturation GO:0051604 233 0.123
amine metabolic process GO:0009308 44 0.117
membrane protein proteolysis GO:0033619 38 0.117
amyloid precursor protein catabolic process GO:0042987 12 0.093
cell activation GO:0001775 213 0.080
leukocyte proliferation GO:0070661 74 0.079
protein processing GO:0016485 226 0.075
membrane lipid metabolic process GO:0006643 53 0.059
lymphocyte proliferation GO:0046651 70 0.057
determination of adult lifespan GO:0008340 2 0.054
lymphocyte activation GO:0046649 133 0.053
positive regulation of immune system process GO:0002684 283 0.053
cytoplasmic transport GO:0016482 379 0.052
vacuole organization GO:0007033 44 0.050
cellular ketone metabolic process GO:0042180 80 0.047
establishment of viral latency GO:0019043 1 0.046
regulation of cellular amino acid metabolic process GO:0006521 6 0.045
cellular chemical homeostasis GO:0055082 180 0.045
exocytosis GO:0006887 71 0.044
protein localization to organelle GO:0033365 280 0.042
secretion GO:0046903 254 0.041
regulation of cellular amine metabolic process GO:0033238 11 0.040
calcium ion transport GO:0006816 147 0.040
chemical homeostasis GO:0048878 306 0.039
multicellular organismal aging GO:0010259 3 0.039
peptide metabolic process GO:0006518 51 0.037
purine ribonucleoside metabolic process GO:0046128 437 0.037
positive regulation of transport GO:0051050 336 0.036
cellular macromolecular complex assembly GO:0034622 324 0.036
neuromuscular junction development GO:0007528 3 0.033
negative regulation of cellular amine metabolic process GO:0033239 3 0.033
cellular amine metabolic process GO:0044106 41 0.033
regulation of cellular ketone metabolic process GO:0010565 50 0.032
negative regulation of catalytic activity GO:0043086 335 0.031
positive regulation of hydrolase activity GO:0051345 331 0.031
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.030
immune response GO:0006955 307 0.030
glycosylation GO:0070085 71 0.030
establishment of protein localization to organelle GO:0072594 172 0.030
secretion by cell GO:0032940 226 0.030
protein glycosylation GO:0006486 62 0.029
myeloid cell homeostasis GO:0002262 34 0.029
macromolecule glycosylation GO:0043413 63 0.029
negative regulation of programmed cell death GO:0043069 321 0.028
response to external biotic stimulus GO:0043207 261 0.027
cellular cation homeostasis GO:0030003 163 0.027
carbohydrate derivative biosynthetic process GO:1901137 207 0.027
ribonucleoside triphosphate metabolic process GO:0009199 412 0.027
regulation of vesicle mediated transport GO:0060627 130 0.027
cation transport GO:0006812 331 0.027
amyloid precursor protein metabolic process GO:0042982 17 0.027
membrane protein ectodomain proteolysis GO:0006509 33 0.026
leukocyte activation GO:0045321 164 0.026
vesicle organization GO:0016050 62 0.026
reactive oxygen species metabolic process GO:0072593 75 0.026
small molecule biosynthetic process GO:0044283 157 0.026
cellular response to dna damage stimulus GO:0006974 379 0.026
positive regulation of cellular catabolic process GO:0031331 284 0.026
ion homeostasis GO:0050801 230 0.026
peripheral nervous system development GO:0007422 2 0.026
viral process GO:0016032 146 0.025
purine nucleoside triphosphate catabolic process GO:0009146 392 0.025
oogenesis GO:0048477 2 0.025
defense response GO:0006952 315 0.025
female gamete generation GO:0007292 2 0.025
carbohydrate metabolic process GO:0005975 207 0.025
divalent inorganic cation transport GO:0072511 158 0.025
cellular amide metabolic process GO:0043603 69 0.024
regulation of cellular component movement GO:0051270 334 0.024
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.024
purine ribonucleoside catabolic process GO:0046130 398 0.024
leukocyte chemotaxis GO:0030595 76 0.024
ribonucleoside triphosphate catabolic process GO:0009203 391 0.024
ras protein signal transduction GO:0007265 73 0.023
cellular amino acid metabolic process GO:0006520 116 0.023
regulation of calcium ion transport GO:0051924 79 0.023
cellular ion homeostasis GO:0006873 168 0.023
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.023
regulation of protein localization GO:0032880 296 0.023
intracellular protein transport GO:0006886 270 0.022
purine containing compound catabolic process GO:0072523 411 0.022
negative regulation of cell death GO:0060548 345 0.022
response to inorganic substance GO:0010035 127 0.021
divalent metal ion transport GO:0070838 152 0.021
positive regulation of secretion GO:0051047 116 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
synaptic vesicle exocytosis GO:0016079 3 0.021
negative regulation of cellular component organization GO:0051129 235 0.021
cellular lipid metabolic process GO:0044255 303 0.021
cellular response to oxygen containing compound GO:1901701 276 0.021
positive regulation of cellular amine metabolic process GO:0033240 7 0.021
nucleoside catabolic process GO:0009164 408 0.021
negative regulation of apoptotic process GO:0043066 316 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
oocyte differentiation GO:0009994 2 0.020
negative regulation of axonogenesis GO:0050771 4 0.020
cilium organization GO:0044782 68 0.020
regulation of intracellular transport GO:0032386 195 0.020
organophosphate catabolic process GO:0046434 430 0.020
maintenance of location GO:0051235 112 0.020
sphingolipid metabolic process GO:0006665 38 0.019
regulation of cell growth GO:0001558 135 0.019
interspecies interaction between organisms GO:0044419 156 0.018
mapk cascade GO:0000165 288 0.018
ubiquitin dependent protein catabolic process GO:0006511 206 0.018
compound eye development GO:0048749 1 0.018
motor neuron axon guidance GO:0008045 2 0.018
posttranscriptional regulation of gene expression GO:0010608 213 0.018
regulation of kinase activity GO:0043549 314 0.018
response to biotic stimulus GO:0009607 276 0.018
vesicle mediated transport GO:0016192 371 0.018
t cell proliferation GO:0042098 45 0.018
cellular macromolecule catabolic process GO:0044265 380 0.018
regulation of establishment of protein localization GO:0070201 242 0.018
negative regulation of cellular protein metabolic process GO:0032269 353 0.018
carboxylic acid biosynthetic process GO:0046394 97 0.018
endosomal transport GO:0016197 129 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
protein targeting GO:0006605 187 0.018
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.018
response to other organism GO:0051707 261 0.017
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.017
segmentation GO:0035282 4 0.017
lipid metabolic process GO:0006629 381 0.017
single organism membrane organization GO:0044802 268 0.017
regeneration GO:0031099 4 0.017
cellular protein catabolic process GO:0044257 261 0.017
transmembrane transport GO:0055085 399 0.017
cellular homeostasis GO:0019725 196 0.017
glycoprotein biosynthetic process GO:0009101 91 0.017
positive regulation of kinase activity GO:0033674 204 0.016
positive regulation of immune response GO:0050778 159 0.016
fatty acid elongation polyunsaturated fatty acid GO:0034626 4 0.016
regulation of protein kinase activity GO:0045859 289 0.016
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 2 0.016
cation homeostasis GO:0055080 189 0.016
positive regulation of calcium ion transport GO:0051928 51 0.016
purine nucleoside triphosphate metabolic process GO:0009144 412 0.016
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.016
regulation of cell migration GO:0030334 289 0.016
purine nucleoside catabolic process GO:0006152 398 0.015
ribonucleoside catabolic process GO:0042454 406 0.015
oocyte development GO:0048599 1 0.015
glycoprotein metabolic process GO:0009100 110 0.015
endocytosis GO:0006897 159 0.015
circulatory system development GO:0072359 262 0.015
regulation of cytoplasmic transport GO:1903649 149 0.015
regulation of synaptic plasticity GO:0048167 3 0.015
regulation of protein complex assembly GO:0043254 147 0.015
signal transduction by phosphorylation GO:0023014 297 0.015
positive regulation of cellular component movement GO:0051272 181 0.015
cell morphogenesis GO:0000902 296 0.015
reactive nitrogen species metabolic process GO:2001057 3 0.015
regulation of cellular response to stress GO:0080135 244 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
locomotory behavior GO:0007626 1 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.015
nucleoside triphosphate metabolic process GO:0009141 422 0.015
nucleoside triphosphate catabolic process GO:0009143 394 0.014
positive regulation of secretion by cell GO:1903532 108 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
positive regulation of locomotion GO:0040017 186 0.014
regulation of cell cycle GO:0051726 393 0.014
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.014
positive regulation of cellular component biogenesis GO:0044089 158 0.014
oxidation reduction process GO:0055114 396 0.014
dna repair GO:0006281 198 0.014
cell part morphogenesis GO:0032990 137 0.014
regulation of transferase activity GO:0051338 355 0.014
regulation of cell motility GO:2000145 299 0.014
cell projection organization GO:0030030 252 0.014
regulation of cytoskeleton organization GO:0051493 177 0.014
nephric duct development GO:0072176 4 0.014
regulation of defense response GO:0031347 154 0.014
blastocyst development GO:0001824 3 0.014
cell growth GO:0016049 160 0.013
growth GO:0040007 202 0.013
sequestering of metal ion GO:0051238 24 0.013
multi organism cellular process GO:0044764 156 0.013
cell projection morphogenesis GO:0048858 129 0.013
positive regulation of programmed cell death GO:0043068 249 0.013
fatty acid elongation monounsaturated fatty acid GO:0034625 3 0.013
lipid biosynthetic process GO:0008610 177 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.013
cell projection assembly GO:0030031 126 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
nucleoside monophosphate metabolic process GO:0009123 191 0.013
single organism membrane fusion GO:0044801 37 0.013
regulation of endopeptidase activity GO:0052548 170 0.013
nuclear transport GO:0051169 179 0.013
innate immune response GO:0045087 178 0.013
nucleotide catabolic process GO:0009166 408 0.013
atp metabolic process GO:0046034 176 0.013
protein catabolic process GO:0030163 325 0.013
hemopoiesis GO:0030097 180 0.013
anatomical structure formation involved in morphogenesis GO:0048646 284 0.013
epithelial cell proliferation GO:0050673 128 0.013
inorganic cation transmembrane transport GO:0098662 194 0.013
memory GO:0007613 3 0.013
positive regulation of apoptotic process GO:0043065 246 0.013
positive regulation of protein kinase activity GO:0045860 190 0.013
small gtpase mediated signal transduction GO:0007264 78 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
negative regulation of phosphate metabolic process GO:0045936 267 0.013
immune effector process GO:0002252 159 0.012
positive regulation of organelle organization GO:0010638 195 0.012
response to oxygen containing compound GO:1901700 369 0.012
positive regulation of protein phosphorylation GO:0001934 313 0.012
ribonucleoside monophosphate metabolic process GO:0009161 187 0.012
limbic system development GO:0021761 3 0.012
blood vessel development GO:0001568 172 0.012
positive regulation of transferase activity GO:0051347 227 0.012
metal ion homeostasis GO:0055065 169 0.012
positive regulation of cell migration GO:0030335 172 0.012
organelle assembly GO:0070925 176 0.012
modification dependent protein catabolic process GO:0019941 209 0.012
microtubule cytoskeleton organization GO:0000226 176 0.012
regulation of protein transport GO:0051223 213 0.012
organic acid biosynthetic process GO:0016053 97 0.012
negative regulation of cell cycle GO:0045786 193 0.012
spermatid differentiation GO:0048515 4 0.012
embryonic epithelial tube formation GO:0001838 4 0.012
mitotic cell cycle GO:0000278 326 0.012
central nervous system development GO:0007417 123 0.012
regulation of growth GO:0040008 165 0.012
positive regulation of behavior GO:0048520 60 0.012
regulation of multi organism process GO:0043900 157 0.012
synaptic vesicle recycling GO:0036465 3 0.012
regulation of mapk cascade GO:0043408 262 0.012
taxis GO:0042330 157 0.011
cell adhesion GO:0007155 325 0.011
leukocyte migration GO:0050900 107 0.011
positive regulation of ion transport GO:0043270 87 0.011
receptor mediated endocytosis GO:0006898 84 0.011
cellular metal ion homeostasis GO:0006875 146 0.011
positive regulation of protein transport GO:0051222 135 0.011
organelle fusion GO:0048284 36 0.011
positive regulation of cell death GO:0010942 263 0.011
purine nucleoside monophosphate metabolic process GO:0009126 186 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
associative learning GO:0008306 1 0.011
regulation of intracellular protein transport GO:0033157 123 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
fatty acid biosynthetic process GO:0006633 46 0.011
mitochondrion organization GO:0007005 156 0.011
cellular protein complex assembly GO:0043623 188 0.011
regulation of protein maturation GO:1903317 150 0.011
positive regulation of catabolic process GO:0009896 310 0.011
regulation of protein processing GO:0070613 150 0.011
cation transmembrane transport GO:0098655 238 0.011
cerebral cortex neuron differentiation GO:0021895 1 0.011
mammary gland morphogenesis GO:0060443 2 0.011
regulation of dna metabolic process GO:0051052 153 0.011
cellular divalent inorganic cation homeostasis GO:0072503 128 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
muscle cell cellular homeostasis GO:0046716 3 0.011
negative regulation of organelle organization GO:0010639 126 0.011
cilium assembly GO:0042384 63 0.011
purine ribonucleotide catabolic process GO:0009154 404 0.011
proteasomal protein catabolic process GO:0010498 176 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
central nervous system projection neuron axonogenesis GO:0021952 3 0.011
rna interference GO:0016246 4 0.011
negative regulation of ligand dependent nuclear receptor transcription coactivator activity GO:2000326 1 0.011
hindbrain development GO:0030902 3 0.011
chromatin organization GO:0006325 351 0.011
head development GO:0060322 108 0.010
negative regulation of protein processing GO:0010955 142 0.010
defense response to other organism GO:0098542 129 0.010
ion transmembrane transport GO:0034220 338 0.010
positive regulation of apoptotic signaling pathway GO:2001235 70 0.010
regulation of protein serine threonine kinase activity GO:0071900 179 0.010
nervous system development GO:0007399 293 0.010
cell development GO:0048468 328 0.010
modification dependent macromolecule catabolic process GO:0043632 212 0.010
nadph oxidation GO:0070995 3 0.010
regulation of ion transport GO:0043269 189 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 37 0.010
regulation of cell division GO:0051302 116 0.010
establishment of protein localization to membrane GO:0090150 121 0.010
positive regulation of nucleotide catabolic process GO:0030813 185 0.010
regulation of proteolysis GO:0030162 293 0.010
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:2000059 3 0.010
adult locomotory behavior GO:0008344 1 0.010
apoptotic signaling pathway GO:0097190 268 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
dephosphorylation GO:0016311 209 0.010
regulation of reactive oxygen species metabolic process GO:2000377 41 0.010
very long chain fatty acid biosynthetic process GO:0042761 7 0.010
negative regulation of protein modification process GO:0031400 200 0.010
central nervous system neuron axonogenesis GO:0021955 3 0.010

PSENEN disease predictions

Disease DO term ID Size Probability Func Analog Org
integumentary system disease DOID:16 43 0.111
cancer DOID:162 167 0.029
disease of cellular proliferation DOID:14566 174 0.029
muscular disease DOID:0080000 114 0.025
musculoskeletal system disease DOID:17 223 0.025
muscle tissue disease DOID:66 113 0.025
disease of mental health DOID:150 70 0.021
skin disease DOID:37 33 0.017
central nervous system disease DOID:331 186 0.012
nervous system disease DOID:863 431 0.012
heart disease DOID:114 68 0.011
cardiovascular system disease DOID:1287 106 0.011
myopathy DOID:423 104 0.010
cardiomyopathy DOID:0050700 50 0.010
intrinsic cardiomyopathy DOID:0060036 50 0.010
dilated cardiomyopathy DOID:12930 32 0.010
organ system cancer DOID:0050686 164 0.010
sweat gland disease DOID:1383 3 0.001
hidradenitis DOID:2282 3 0.001
hidradenitis suppurativa DOID:2280 3 0.001