Homo sapiens

9 known processes

PSMB8

proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)

(Aliases: D6S216E,D6S216,LMP7,MGC1491,PSMB5i,RING10)

PSMB8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.998
Yeast
antigen processing and presentation GO:0019882 33 0.958
Mouse
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.777
Yeast
viral process GO:0016032 146 0.616
protein catabolic process GO:0030163 325 0.608
Yeast
multi organism localization GO:1902579 14 0.596
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.588
cellular protein catabolic process GO:0044257 261 0.498
Yeast
defense response to other organism GO:0098542 129 0.492
modification dependent protein catabolic process GO:0019941 209 0.489
Yeast
ubiquitin dependent protein catabolic process GO:0006511 206 0.488
Yeast
antigen processing and presentation via mhc class ib GO:0002475 3 0.470
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.451
Yeast
immune effector process GO:0002252 159 0.448
regulation of immune response GO:0050776 201 0.359
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.344
negative regulation of defense response GO:0031348 47 0.344
mononuclear cell proliferation GO:0032943 71 0.315
antigen processing and presentation of exogenous antigen GO:0019884 4 0.306
antigen processing and presentation of peptide antigen GO:0048002 18 0.287
immune response GO:0006955 307 0.285
leukocyte mediated immunity GO:0002443 59 0.282
sensory perception of chemical stimulus GO:0007606 38 0.268
cellular macromolecule catabolic process GO:0044265 380 0.262
Yeast
positive regulation of peptidase activity GO:0010952 88 0.251
transport of virus GO:0046794 14 0.240
multi organism transport GO:0044766 14 0.219
negative regulation of natural killer cell mediated cytotoxicity GO:0045953 5 0.215
response to external biotic stimulus GO:0043207 261 0.204
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.195
response to other organism GO:0051707 261 0.183
regulation of proteasomal protein catabolic process GO:0061136 87 0.182
modification dependent macromolecule catabolic process GO:0043632 212 0.179
Yeast
negative regulation of intracellular transport of viral material GO:1901253 2 0.177
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.176
regulation of proteolysis GO:0030162 293 0.174
interspecies interaction between organisms GO:0044419 156 0.174
defense response GO:0006952 315 0.147
peptide transport GO:0015833 74 0.144
negative regulation of immune response GO:0050777 40 0.143
intracellular transport of viral protein in host cell GO:0019060 4 0.136
negative regulation of immune system process GO:0002683 136 0.136
isg15 protein conjugation GO:0032020 5 0.133
natural killer cell mediated cytotoxicity GO:0042267 23 0.131
viral life cycle GO:0019058 132 0.120
positive regulation of endopeptidase activity GO:0010950 84 0.119
antigen processing and presentation of peptide antigen via mhc class i GO:0002474 6 0.106
regulation of fas signaling pathway GO:1902044 2 0.103
leukocyte mediated cytotoxicity GO:0001909 27 0.102
t cell proliferation GO:0042098 45 0.100
positive regulation of leukocyte activation GO:0002696 80 0.099
proteasomal protein catabolic process GO:0010498 176 0.097
Yeast
chemical homeostasis GO:0048878 306 0.091
regulation of cellular protein catabolic process GO:1903362 96 0.090
positive regulation of immune effector process GO:0002699 40 0.087
purine nucleotide catabolic process GO:0006195 405 0.086
intracellular protein transport GO:0006886 270 0.081
nucleoside triphosphate catabolic process GO:0009143 394 0.081
regulation of interferon gamma production GO:0032649 36 0.078
positive regulation of leukocyte mediated immunity GO:0002705 24 0.078
intracellular transport of virus GO:0075733 14 0.078
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.074
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.073
regulation of peptidase activity GO:0052547 180 0.072
cellular response to cytokine stimulus GO:0071345 181 0.069
purine nucleoside catabolic process GO:0006152 398 0.068
multi organism intracellular transport GO:1902583 14 0.066
multi organism metabolic process GO:0044033 41 0.065
regulation of transferase activity GO:0051338 355 0.064
positive regulation of secretion GO:0051047 116 0.064
t cell activation GO:0042110 99 0.064
negative regulation of apoptotic signaling pathway GO:2001234 97 0.062
regulation of natural killer cell mediated immunity GO:0002715 16 0.061
positive regulation of immune system process GO:0002684 283 0.061
regulation of multi organism process GO:0043900 157 0.061
regulation of t cell mediated immunity GO:0002709 18 0.060
regulation of adaptive immune response GO:0002819 33 0.059
positive regulation of developmental process GO:0051094 314 0.058
regulation of apoptotic signaling pathway GO:2001233 175 0.057
positive regulation of hydrolase activity GO:0051345 331 0.056
innate immune response GO:0045087 178 0.054
purine ribonucleotide catabolic process GO:0009154 404 0.054
nucleotide catabolic process GO:0009166 408 0.051
positive regulation of leukocyte mediated cytotoxicity GO:0001912 16 0.050
antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway GO:0002484 3 0.050
lymphocyte mediated immunity GO:0002449 48 0.050
cell activation GO:0001775 213 0.050
extrinsic apoptotic signaling pathway GO:0097191 119 0.050
cellular component morphogenesis GO:0032989 314 0.049
positive regulation of cell activation GO:0050867 81 0.048
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.047
antigen processing and presentation of endogenous peptide antigen GO:0002483 6 0.046
negative regulation of cell death GO:0060548 345 0.046
regulation of leukocyte mediated immunity GO:0002703 38 0.045
protection from natural killer cell mediated cytotoxicity GO:0042270 3 0.045
regulation by virus of viral protein levels in host cell GO:0046719 4 0.044
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.043
regulation of protein catabolic process GO:0042176 155 0.041
amide transport GO:0042886 76 0.041
multi organism cellular process GO:0044764 156 0.041
regulation of cell killing GO:0031341 22 0.041
negative regulation of leukocyte mediated immunity GO:0002704 14 0.040
apoptotic signaling pathway GO:0097190 268 0.039
negative regulation of kinase activity GO:0033673 106 0.039
purine containing compound catabolic process GO:0072523 411 0.039
lymphocyte proliferation GO:0046651 70 0.039
negative regulation of viral transcription GO:0032897 23 0.039
movement in environment of other organism involved in symbiotic interaction GO:0052192 25 0.039
regulation of defense response GO:0031347 154 0.039
response to biotic stimulus GO:0009607 276 0.039
regulation of innate immune response GO:0045088 97 0.038
nucleoside monophosphate metabolic process GO:0009123 191 0.037
purine nucleoside monophosphate metabolic process GO:0009126 186 0.037
negative regulation of cell migration GO:0030336 102 0.037
leukocyte activation GO:0045321 164 0.037
positive regulation of adaptive immune response GO:0002821 21 0.036
cytoplasmic transport GO:0016482 379 0.035
immune response activating signal transduction GO:0002757 90 0.034
regulation of endopeptidase activity GO:0052548 170 0.034
regulation of leukocyte activation GO:0002694 115 0.034
regulation of circadian sleep wake cycle GO:0042749 2 0.034
leukocyte proliferation GO:0070661 74 0.033
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.033
negative regulation of lymphocyte mediated immunity GO:0002707 12 0.032
positive regulation of t cell mediated immunity GO:0002711 12 0.032
cell killing GO:0001906 34 0.032
regulation of cellular component movement GO:0051270 334 0.032
natural killer cell mediated immunity GO:0002228 23 0.032
positive regulation of proteolysis GO:0045862 142 0.031
secretion GO:0046903 254 0.030
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.029
nitrogen compound transport GO:0071705 191 0.027
inorganic ion transmembrane transport GO:0098660 231 0.026
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.026
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.024
nucleoside phosphate biosynthetic process GO:1901293 109 0.024
interaction with host GO:0051701 42 0.024
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
regeneration GO:0031099 4 0.024
cation transport GO:0006812 331 0.023
negative regulation of cell motility GO:2000146 104 0.023
cell morphogenesis GO:0000902 296 0.023
oogenesis GO:0048477 2 0.023
purine ribonucleoside catabolic process GO:0046130 398 0.022
positive regulation of cell differentiation GO:0045597 211 0.022
regulation of leukocyte proliferation GO:0070663 67 0.022
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.021
intracellular protein transport in other organism involved in symbiotic interaction GO:0051708 4 0.021
regulation of mononuclear cell proliferation GO:0032944 65 0.021
detection of chemical stimulus GO:0009593 55 0.021
regulation of regulatory t cell differentiation GO:0045589 4 0.021
regulation of interleukin 10 secretion GO:2001179 4 0.020
regulation of antigen processing and presentation of peptide antigen GO:0002583 4 0.019
regulation of cytoskeleton organization GO:0051493 177 0.019
regulation of viral process GO:0050792 103 0.019
blastocyst development GO:0001824 3 0.019
negative regulation of viral process GO:0048525 66 0.019
positive regulation of protein secretion GO:0050714 60 0.018
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.018
cd8 positive alpha beta t cell activation GO:0036037 3 0.018
regulation of t cell activation GO:0050863 77 0.018
regulation of establishment of protein localization GO:0070201 242 0.018
negative regulation of leukocyte mediated cytotoxicity GO:0001911 5 0.018
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.018
positive regulation of lymphocyte activation GO:0051251 73 0.018
negative regulation of innate immune response GO:0045824 18 0.018
system process GO:0003008 349 0.017
symbiont intracellular protein transport in host GO:0030581 4 0.017
extracellular transport GO:0006858 4 0.016
positive regulation of secretion by cell GO:1903532 108 0.016
positive regulation of activated t cell proliferation GO:0042104 11 0.016
response to bacterium GO:0009617 144 0.016
regulation of lymphocyte mediated immunity GO:0002706 33 0.016
negative regulation of catalytic activity GO:0043086 335 0.016
regulation of cell migration GO:0030334 289 0.016
regulation of actin filament based process GO:0032970 141 0.016
ribonucleoside catabolic process GO:0042454 406 0.015
antigen processing and presentation of endogenous peptide antigen via mhc class ib GO:0002476 2 0.015
cellular response to external stimulus GO:0071496 111 0.015
cellular ketone metabolic process GO:0042180 80 0.015
regulation of cell motility GO:2000145 299 0.015
inflammatory response to antigenic stimulus GO:0002437 4 0.015
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.015
regulation of cell activation GO:0050865 125 0.014
positive regulation of antigen processing and presentation GO:0002579 1 0.014
lymphocyte activation GO:0046649 133 0.014
regulation of secretion GO:0051046 194 0.014
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
regulation of cell cycle phase transition GO:1901987 126 0.013
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
regulation of cellular component biogenesis GO:0044087 281 0.013
organophosphate catabolic process GO:0046434 430 0.013
guanosine containing compound catabolic process GO:1901069 239 0.013
positive regulation of cytokine secretion GO:0050715 42 0.013
positive regulation of protein complex assembly GO:0031334 86 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
syncytium formation by plasma membrane fusion GO:0000768 2 0.013
negative regulation of programmed cell death GO:0043069 321 0.013
positive regulation of cellular component organization GO:0051130 376 0.012
regulation of t cell differentiation GO:0045580 19 0.012
positive regulation of mononuclear cell proliferation GO:0032946 47 0.012
regulation of ligase activity GO:0051340 29 0.012
adenosine to inosine editing GO:0006382 3 0.012
mitotic spindle elongation GO:0000022 4 0.012
Fly
spermatid differentiation GO:0048515 4 0.012
cellular homeostasis GO:0019725 196 0.012
cation transmembrane transport GO:0098655 238 0.012
positive regulation of protein transport GO:0051222 135 0.012
ribonucleotide catabolic process GO:0009261 405 0.012
regulation of secretion by cell GO:1903530 177 0.011
divalent metal ion transport GO:0070838 152 0.011
regulation of interleukin 10 production GO:0032653 16 0.011
negative regulation of phosphate metabolic process GO:0045936 267 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
regulation of type i interferon production GO:0032479 26 0.011
secretion by cell GO:0032940 226 0.011
regulation of cellular component size GO:0032535 82 0.011
negative regulation of apoptotic process GO:0043066 316 0.011
antigen processing and presentation of peptide antigen via mhc class ib GO:0002428 2 0.011
activation of innate immune response GO:0002218 55 0.011
arp2 3 complex mediated actin nucleation GO:0034314 17 0.010
sensory organ development GO:0007423 52 0.010
spermatid development GO:0007286 4 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010
purine nucleotide biosynthetic process GO:0006164 84 0.010
negative regulation of protein phosphorylation GO:0001933 140 0.010
positive regulation of immune response GO:0050778 159 0.010
purine ribonucleoside metabolic process GO:0046128 437 0.010
positive regulation of cellular component biogenesis GO:0044089 158 0.010
positive regulation of transport GO:0051050 336 0.010
negative regulation of developmental process GO:0051093 247 0.010

PSMB8 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.588
primary immunodeficiency disease DOID:612 36 0.522
severe combined immunodeficiency DOID:627 10 0.353
combined t cell and b cell immunodeficiency DOID:628 12 0.353
cancer DOID:162 167 0.022
disease of cellular proliferation DOID:14566 174 0.022
organ system cancer DOID:0050686 164 0.022
musculoskeletal system disease DOID:17 223 0.012