Homo sapiens

0 known processes

PSMD2

proteasome (prosome, macropain) 26S subunit, non-ATPase, 2

(Aliases: Rpn1,TRAP2,MGC14274,S2,P97)

PSMD2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.999
proteasome regulatory particle assembly GO:0070682 2 0.998
cellular response to dna damage stimulus GO:0006974 379 0.995
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.966
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.965
determination of adult lifespan GO:0008340 2 0.940
Worm
modification dependent protein catabolic process GO:0019941 209 0.940
nucleotide excision repair GO:0006289 31 0.932
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 3 0.928
multicellular organismal aging GO:0010259 3 0.915
Worm
purine nucleoside monophosphate catabolic process GO:0009128 158 0.913
dna templated transcription initiation GO:0006352 35 0.908
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.892
ubiquitin dependent protein catabolic process GO:0006511 206 0.873
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.868
cellular protein catabolic process GO:0044257 261 0.866
positive regulation of protein phosphorylation GO:0001934 313 0.865
cellular macromolecular complex assembly GO:0034622 324 0.857
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.841
proteasomal protein catabolic process GO:0010498 176 0.830
protein dna complex assembly GO:0065004 64 0.830
protein dna complex subunit organization GO:0071824 80 0.821
mitotic spindle elongation GO:0000022 4 0.817
Fly
proteasome assembly GO:0043248 7 0.816
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.796
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.788
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.784
spindle elongation GO:0051231 4 0.783
Fly
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.780
modification dependent macromolecule catabolic process GO:0043632 212 0.771
atp catabolic process GO:0006200 157 0.740
blastocyst development GO:0001824 3 0.735
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.727
regulation of proteasomal protein catabolic process GO:0061136 87 0.727
post embryonic development GO:0009791 2 0.719
Worm
positive regulation of peptidase activity GO:0010952 88 0.651
regulation of dna templated transcription initiation GO:2000142 9 0.616
atp metabolic process GO:0046034 176 0.591
nucleoside monophosphate catabolic process GO:0009125 159 0.589
microtubule cytoskeleton organization GO:0000226 176 0.587
Fly
protein catabolic process GO:0030163 325 0.572
nucleoside triphosphate catabolic process GO:0009143 394 0.569
metaphase anaphase transition of cell cycle GO:0044784 21 0.566
i kappab kinase nf kappab signaling GO:0007249 166 0.565
regulation of peptidase activity GO:0052547 180 0.547
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.531
positive regulation of protein complex assembly GO:0031334 86 0.525
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.495
positive regulation of endopeptidase activity GO:0010950 84 0.483
regulation of cellular protein catabolic process GO:1903362 96 0.477
cellular protein complex assembly GO:0043623 188 0.477
nucleoside catabolic process GO:0009164 408 0.464
regulation of protein complex assembly GO:0043254 147 0.461
dna templated transcriptional preinitiation complex assembly GO:0070897 5 0.460
dna templated transcription elongation GO:0006354 25 0.455
regulation of proteolysis GO:0030162 293 0.452
rna catabolic process GO:0006401 71 0.442
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 10 0.427
chromatin organization GO:0006325 351 0.412
protein deubiquitination GO:0016579 79 0.382
regulation of sister chromatid segregation GO:0033045 27 0.376
signal transduction in response to dna damage GO:0042770 57 0.354
nucleoside phosphate catabolic process GO:1901292 412 0.351
ribonucleoside catabolic process GO:0042454 406 0.350
mitotic sister chromatid segregation GO:0000070 53 0.344
purine ribonucleotide catabolic process GO:0009154 404 0.343
nervous system development GO:0007399 293 0.341
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.330
protein deglycosylation GO:0006517 2 0.321
positive regulation of cellular protein catabolic process GO:1903364 37 0.316
ribonucleoside triphosphate catabolic process GO:0009203 391 0.293
regulation of mitotic cell cycle GO:0007346 189 0.284
dna repair GO:0006281 198 0.277
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 8 0.276
positive regulation of protein kinase activity GO:0045860 190 0.267
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.262
aging GO:0007568 66 0.262
Worm
purine nucleoside catabolic process GO:0006152 398 0.258
ribonucleoside monophosphate catabolic process GO:0009158 158 0.255
regulation of mitotic sister chromatid separation GO:0010965 27 0.252
regulation of endopeptidase activity GO:0052548 170 0.251
regulation of cell cycle GO:0051726 393 0.249
negative regulation of peptidase activity GO:0010466 91 0.243
sister chromatid segregation GO:0000819 54 0.243
purine nucleoside triphosphate catabolic process GO:0009146 392 0.237
purine nucleotide catabolic process GO:0006195 405 0.230
mitotic cell cycle GO:0000278 326 0.229
Fly
glycosyl compound catabolic process GO:1901658 413 0.223
cell division GO:0051301 168 0.222
secretion by cell GO:0032940 226 0.222
purine ribonucleoside metabolic process GO:0046128 437 0.216
positive regulation of dna templated transcription elongation GO:0032786 18 0.216
negative regulation of endopeptidase activity GO:0010951 84 0.207
nucleoside monophosphate metabolic process GO:0009123 191 0.204
oogenesis GO:0048477 2 0.203
regulation of chromosome segregation GO:0051983 44 0.200
mitotic cell cycle process GO:1903047 286 0.197
Fly
regulation of cellular component biogenesis GO:0044087 281 0.196
ribonucleoside triphosphate metabolic process GO:0009199 412 0.186
rna interference GO:0016246 4 0.186
positive regulation of kinase activity GO:0033674 204 0.181
ribonucleoside monophosphate metabolic process GO:0009161 187 0.180
ribonucleotide catabolic process GO:0009261 405 0.179
nucleoside triphosphate metabolic process GO:0009141 422 0.175
organelle fission GO:0048285 149 0.171
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.166
inclusion body assembly GO:0070841 17 0.163
purine containing compound catabolic process GO:0072523 411 0.160
regulation of protein catabolic process GO:0042176 155 0.158
myeloid dendritic cell differentiation GO:0043011 3 0.156
chromatin modification GO:0016568 298 0.156
purine ribonucleoside catabolic process GO:0046130 398 0.156
ovarian follicle development GO:0001541 5 0.155
regulation of cell division GO:0051302 116 0.153
chromosome separation GO:0051304 23 0.150
positive regulation of phosphorylation GO:0042327 394 0.150
positive regulation of cellular catabolic process GO:0031331 284 0.149
cellular macromolecule catabolic process GO:0044265 380 0.147
protein modification by small protein conjugation GO:0032446 342 0.146
purine nucleoside triphosphate metabolic process GO:0009144 412 0.144
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.142
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.140
nucleotide catabolic process GO:0009166 408 0.137
maintenance of protein location in cell GO:0032507 56 0.133
double strand break repair via nonhomologous end joining GO:0006303 10 0.131
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.126
regulation of protein ubiquitination GO:0031396 95 0.123
positive regulation of protein catabolic process GO:0045732 75 0.122
leukocyte differentiation GO:0002521 98 0.122
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.121
spermatid differentiation GO:0048515 4 0.118
ovulation cycle process GO:0022602 9 0.118
regulation of dna templated transcription elongation GO:0032784 23 0.116
cellular response to oxygen levels GO:0071453 55 0.115
negative regulation of i kappab kinase nf kappab signaling GO:0043124 32 0.114
immune system development GO:0002520 195 0.113
mitochondrion organization GO:0007005 156 0.112
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.110
regulation of nuclear division GO:0051783 65 0.110
non recombinational repair GO:0000726 14 0.109
female gamete generation GO:0007292 2 0.106
negative regulation of proteolysis GO:0045861 132 0.105
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.097
response to organonitrogen compound GO:0010243 156 0.096
spermatid development GO:0007286 4 0.096
positive regulation of proteolysis GO:0045862 142 0.096
mitotic cell cycle phase transition GO:0044772 162 0.095
signal transduction by p53 class mediator GO:0072331 72 0.094
regulation of cell cycle process GO:0010564 266 0.092
lymphocyte activation GO:0046649 133 0.089
positive regulation of cellular component organization GO:0051130 376 0.088
maintenance of location GO:0051235 112 0.087
regulation of cell growth GO:0001558 135 0.085
hemopoiesis GO:0030097 180 0.084
regulation of transferase activity GO:0051338 355 0.083
regulation of apoptotic signaling pathway GO:2001233 175 0.082
regulation of mitotic sister chromatid segregation GO:0033047 27 0.080
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.079
midbrain development GO:0030901 45 0.079
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.078
response to oxygen containing compound GO:1901700 369 0.074
signal transduction by phosphorylation GO:0023014 297 0.071
nuclear division GO:0000280 128 0.070
regulation of kinase activity GO:0043549 314 0.069
purine nucleoside monophosphate metabolic process GO:0009126 186 0.068
negative regulation of organelle organization GO:0010639 126 0.068
apoptotic mitochondrial changes GO:0008637 57 0.066
chromatin remodeling GO:0006338 55 0.066
immunoglobulin secretion GO:0048305 1 0.064
negative regulation of phosphate metabolic process GO:0045936 267 0.062
positive regulation of cellular component biogenesis GO:0044089 158 0.061
gene silencing by rna GO:0031047 26 0.058
mitotic nuclear division GO:0007067 119 0.057
chromosome segregation GO:0007059 114 0.056
cell activation GO:0001775 213 0.055
protein localization to organelle GO:0033365 280 0.055
regulation of nf kappab import into nucleus GO:0042345 22 0.054
negative regulation of transport GO:0051051 176 0.053
brain morphogenesis GO:0048854 1 0.053
apoptotic signaling pathway GO:0097190 268 0.053
cell cycle phase transition GO:0044770 173 0.050
regulation of response to dna damage stimulus GO:2001020 94 0.050
response to abiotic stimulus GO:0009628 336 0.050
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.049
negative regulation of protein metabolic process GO:0051248 391 0.049
negative regulation of phosphorylation GO:0042326 174 0.049
maintenance of location in cell GO:0051651 62 0.047
regulation of chromosome organization GO:0033044 103 0.047
protein ubiquitination GO:0016567 314 0.047
positive regulation of dna templated transcription initiation GO:2000144 5 0.046
regulation of immunoglobulin secretion GO:0051023 1 0.045
negative regulation of protein processing GO:0010955 142 0.044
regulation of t cell activation GO:0050863 77 0.044
regulation of gene expression epigenetic GO:0040029 73 0.044
regulation of cell differentiation GO:0045595 393 0.043
mitotic sister chromatid separation GO:0051306 18 0.042
regulation of mapk cascade GO:0043408 262 0.042
regulation of protein kinase activity GO:0045859 289 0.040
monoubiquitinated histone deubiquitination GO:0035521 3 0.040
negative regulation of cell death GO:0060548 345 0.040
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.040
positive regulation of cell cycle GO:0045787 140 0.039
negative regulation of phosphorus metabolic process GO:0010563 267 0.038
cell growth GO:0016049 160 0.038
regulation of release of cytochrome c from mitochondria GO:0090199 29 0.037
protein secretion GO:0009306 98 0.037
response to cytokine GO:0034097 232 0.037
meiosis i GO:0007127 4 0.035
negative regulation of intracellular signal transduction GO:1902532 183 0.034
thymus development GO:0048538 3 0.034
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.034
regulation of t cell differentiation in thymus GO:0033081 2 0.033
response to decreased oxygen levels GO:0036293 96 0.033
hematopoietic or lymphoid organ development GO:0048534 186 0.033
regulation of protein localization GO:0032880 296 0.033
cellular response to cytokine stimulus GO:0071345 181 0.033
amide transport GO:0042886 76 0.032
cytoplasmic transport GO:0016482 379 0.032
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.032
regulation of protein serine threonine kinase activity GO:0071900 179 0.032
regulation of protein transport GO:0051223 213 0.031
negative regulation of cellular protein metabolic process GO:0032269 353 0.031
taxis GO:0042330 157 0.031
organelle assembly GO:0070925 176 0.031
mapk cascade GO:0000165 288 0.031
growth GO:0040007 202 0.030
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.030
negative regulation of catalytic activity GO:0043086 335 0.030
response to starvation GO:0042594 59 0.029
response to nitrogen compound GO:1901698 184 0.029
head development GO:0060322 108 0.028
release of cytochrome c from mitochondria GO:0001836 35 0.028
neurogenesis GO:0022008 169 0.027
myeloid cell differentiation GO:0030099 117 0.027
protein modification by small protein removal GO:0070646 92 0.027
intracellular protein transport GO:0006886 270 0.027
regulation of hormone levels GO:0010817 125 0.027
negative regulation of mapk cascade GO:0043409 56 0.027
negative regulation of apoptotic process GO:0043066 316 0.026
negative regulation of nucleocytoplasmic transport GO:0046823 37 0.026
embryo development ending in birth or egg hatching GO:0009792 34 0.025
Worm
nitrogen compound transport GO:0071705 191 0.025
enzyme linked receptor protein signaling pathway GO:0007167 303 0.025
posttranscriptional gene silencing GO:0016441 25 0.025
angiogenesis GO:0001525 147 0.025
defense response GO:0006952 315 0.025
positive regulation of cell growth GO:0030307 48 0.024
multicellular organism reproduction GO:0032504 42 0.024
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.024
protein k63 linked deubiquitination GO:0070536 21 0.024
embryo development GO:0009790 123 0.024
Worm
regulation of nucleocytoplasmic transport GO:0046822 98 0.024
regulation of protein maturation GO:1903317 150 0.023
protein processing GO:0016485 226 0.023
negative regulation of multicellular organismal process GO:0051241 317 0.023
cellular response to hypoxia GO:0071456 51 0.023
negative regulation of intracellular protein transport GO:0090317 42 0.023
regulation of protein import into nucleus GO:0042306 78 0.023
protein localization to nucleus GO:0034504 136 0.023
negative regulation of protein localization to nucleus GO:1900181 34 0.023
cardiovascular system development GO:0072358 262 0.022
cellular response to peptide GO:1901653 59 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
cytokine mediated signaling pathway GO:0019221 109 0.022
regulation of cell activation GO:0050865 125 0.022
spindle assembly GO:0051225 29 0.022
blood vessel development GO:0001568 172 0.022
leukocyte activation GO:0045321 164 0.021
double strand break repair GO:0006302 101 0.021
protein targeting GO:0006605 187 0.021
g protein coupled receptor signaling pathway GO:0007186 207 0.021
negative regulation of protein modification process GO:0031400 200 0.020
circulatory system development GO:0072359 262 0.020
monoubiquitinated histone h2a deubiquitination GO:0035522 3 0.020
cell cell signaling GO:0007267 155 0.020
gene silencing GO:0016458 49 0.020
cellular response to decreased oxygen levels GO:0036294 51 0.020
recombinational repair GO:0000725 50 0.020
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.020
single organism membrane organization GO:0044802 268 0.020
negative regulation of programmed cell death GO:0043069 321 0.019
chordate embryonic development GO:0043009 34 0.019
negative regulation of protein import into nucleus GO:0042308 30 0.019
epithelial cell differentiation GO:0030855 141 0.018
protein maturation GO:0051604 233 0.018
oocyte development GO:0048599 1 0.018
negative regulation of intracellular transport GO:0032387 60 0.018
ovulation cycle GO:0042698 9 0.018
cellular response to extracellular stimulus GO:0031668 72 0.018
microtubule based process GO:0007017 210 0.018
Fly
nuclear transport GO:0051169 179 0.018
positive regulation of protein ubiquitination GO:0031398 53 0.018
reproduction GO:0000003 63 0.017
Worm
sensory organ development GO:0007423 52 0.017
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.017
protein import GO:0017038 130 0.017
adipose tissue development GO:0060612 2 0.017
negative regulation of protein maturation GO:1903318 142 0.017
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 4 0.017
negative regulation of apoptotic signaling pathway GO:2001234 97 0.017
negative regulation of hydrolase activity GO:0051346 182 0.017
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.017
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.017
peripheral nervous system development GO:0007422 2 0.016
secretion GO:0046903 254 0.016
macroautophagy GO:0016236 39 0.016
regulation of vesicle mediated transport GO:0060627 130 0.016
negative regulation of nf kappab import into nucleus GO:0042347 12 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.016
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 15 0.016
regulation of exit from mitosis GO:0007096 6 0.016
dna geometric change GO:0032392 32 0.016
nf kappab import into nucleus GO:0042348 22 0.016
peroxisome fission GO:0016559 10 0.015
response to peptide hormone GO:0043434 61 0.015
neuroblast proliferation GO:0007405 4 0.015
cellular response to oxygen containing compound GO:1901701 276 0.015
regulation of protein processing GO:0070613 150 0.015
double strand break repair via homologous recombination GO:0000724 50 0.015
response to hypoxia GO:0001666 96 0.015
negative regulation of response to dna damage stimulus GO:2001021 33 0.015
response to peptide GO:1901652 65 0.015
regulation of vasculature development GO:1901342 97 0.014
innate immune response GO:0045087 178 0.014
golgi vesicle transport GO:0048193 80 0.014
regulation of protein targeting GO:1903533 91 0.014
response to nutrient levels GO:0031667 81 0.014
regulation of cytoplasmic transport GO:1903649 149 0.014
cellular response to external stimulus GO:0071496 111 0.013
chemical homeostasis GO:0048878 306 0.013
primary neural tube formation GO:0014020 3 0.013
negative regulation of cytoplasmic transport GO:1903650 46 0.013
positive regulation of neural precursor cell proliferation GO:2000179 2 0.013
response to fungus GO:0009620 4 0.013
embryonic placenta development GO:0001892 1 0.013
positive regulation of hydrolase activity GO:0051345 331 0.013
dna conformation change GO:0071103 113 0.013
protein localization to membrane GO:0072657 160 0.012
positive regulation of catabolic process GO:0009896 310 0.012
schwann cell differentiation GO:0014037 1 0.012
posttranscriptional regulation of gene expression GO:0010608 213 0.012
renal system development GO:0072001 63 0.012
single organism cellular localization GO:1902580 332 0.012
blood vessel morphogenesis GO:0048514 162 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
regulation of mitochondrion organization GO:0010821 54 0.012
ncrna metabolic process GO:0034660 108 0.012
molting cycle GO:0042303 28 0.012
regulation of peptide transport GO:0090087 62 0.012
regulation of myeloid cell differentiation GO:0045637 81 0.012
anatomical structure homeostasis GO:0060249 100 0.012
chromatin assembly or disassembly GO:0006333 78 0.012
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.011
negative regulation of protein transport GO:0051224 75 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
dephosphorylation GO:0016311 209 0.011
negative regulation of signal transduction by p53 class mediator GO:1901797 15 0.011
microtubule organizing center organization GO:0031023 62 0.011
cellular response to starvation GO:0009267 58 0.011
cellular response to nitrogen compound GO:1901699 144 0.011
organophosphate catabolic process GO:0046434 430 0.011
rna splicing via transesterification reactions GO:0000375 90 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.010
regulation of cellular ketone metabolic process GO:0010565 50 0.010
lens development in camera type eye GO:0002088 2 0.010
positive regulation of cell cycle process GO:0090068 106 0.010
rrna metabolic process GO:0016072 40 0.010
neurological system process GO:0050877 163 0.010
regulation of establishment of protein localization GO:0070201 242 0.010
endomembrane system organization GO:0010256 196 0.010
cellular response to growth hormone stimulus GO:0071378 10 0.010

PSMD2 disease predictions

Disease DO term ID Size Probability Func Analog Org
neuromuscular disease DOID:440 38 0.025
nervous system disease DOID:863 431 0.025
neuropathy DOID:870 52 0.025
muscular disease DOID:0080000 114 0.016
musculoskeletal system disease DOID:17 223 0.016
charcot marie tooth disease type 4 DOID:0050541 11 0.013
charcot marie tooth disease DOID:10595 33 0.013