Homo sapiens

0 known processes

PSMD4

proteasome (prosome, macropain) 26S subunit, non-ATPase, 4

(Aliases: S5A,AF,AF-1,ASF,pUB-R5,Rpn10,MCB1)

PSMD4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
modification dependent macromolecule catabolic process GO:0043632 212 1.000
Yeast Worm
ubiquitin dependent protein catabolic process GO:0006511 206 1.000
Yeast Worm
proteasomal protein catabolic process GO:0010498 176 1.000
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 1.000
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 1.000
modification dependent protein catabolic process GO:0019941 209 1.000
Yeast Worm
protein catabolic process GO:0030163 325 1.000
Yeast Worm
multicellular organismal aging GO:0010259 3 0.999
Worm
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.998
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 3 0.998
cellular macromolecule catabolic process GO:0044265 380 0.998
Yeast Worm
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.998
Yeast Worm
cellular protein catabolic process GO:0044257 261 0.998
Yeast Worm
protein deubiquitination GO:0016579 79 0.997
proteasomal ubiquitin independent protein catabolic process GO:0010499 3 0.996
determination of adult lifespan GO:0008340 2 0.995
Worm
proteasome assembly GO:0043248 7 0.995
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.994
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.990
post embryonic development GO:0009791 2 0.985
Worm
regulation of proteasomal protein catabolic process GO:0061136 87 0.984
nucleotide excision repair GO:0006289 31 0.983
blastocyst development GO:0001824 3 0.976
cellular protein complex assembly GO:0043623 188 0.972
protein deglycosylation GO:0006517 2 0.972
spindle elongation GO:0051231 4 0.967
cellular macromolecular complex assembly GO:0034622 324 0.964
mitotic spindle elongation GO:0000022 4 0.960
protein ubiquitination GO:0016567 314 0.936
Fly
protein k63 linked deubiquitination GO:0070536 21 0.936
atp metabolic process GO:0046034 176 0.932
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.926
epithelium development GO:0060429 227 0.925
dna templated transcription initiation GO:0006352 35 0.893
proteasome regulatory particle assembly GO:0070682 2 0.891
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.875
microtubule cytoskeleton organization GO:0000226 176 0.854
aging GO:0007568 66 0.854
Worm
cellular response to dna damage stimulus GO:0006974 379 0.851
Fly
regulation of peptidase activity GO:0052547 180 0.850
negative regulation of peptidase activity GO:0010466 91 0.839
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.835
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.833
atp catabolic process GO:0006200 157 0.824
microtubule based process GO:0007017 210 0.809
protein modification by small protein removal GO:0070646 92 0.800
positive regulation of peptidase activity GO:0010952 88 0.800
dna repair GO:0006281 198 0.796
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.790
ovarian follicle development GO:0001541 5 0.776
purine nucleoside monophosphate metabolic process GO:0009126 186 0.765
positive regulation of catabolic process GO:0009896 310 0.761
negative regulation of phosphorylation GO:0042326 174 0.745
positive regulation of proteolysis GO:0045862 142 0.741
positive regulation of cellular catabolic process GO:0031331 284 0.733
regulation of cellular protein catabolic process GO:1903362 96 0.726
purine nucleoside monophosphate catabolic process GO:0009128 158 0.719
organelle fission GO:0048285 149 0.716
regulation of endopeptidase activity GO:0052548 170 0.713
nervous system development GO:0007399 293 0.701
enzyme linked receptor protein signaling pathway GO:0007167 303 0.687
positive regulation of protein catabolic process GO:0045732 75 0.677
regulation of proteolysis GO:0030162 293 0.674
oogenesis GO:0048477 2 0.663
nucleoside monophosphate metabolic process GO:0009123 191 0.662
spermatid differentiation GO:0048515 4 0.649
embryo development ending in birth or egg hatching GO:0009792 34 0.648
epithelial cell differentiation GO:0030855 141 0.644
regulation of protein ubiquitination GO:0031396 95 0.623
Fly
ribonucleoside monophosphate catabolic process GO:0009158 158 0.621
regulation of cellular component biogenesis GO:0044087 281 0.602
embryo development GO:0009790 123 0.584
nucleoside catabolic process GO:0009164 408 0.584
regulation of protein catabolic process GO:0042176 155 0.549
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.539
spermatid development GO:0007286 4 0.532
positive regulation of cellular protein catabolic process GO:1903364 37 0.528
nucleoside triphosphate catabolic process GO:0009143 394 0.506
ribonucleoside monophosphate metabolic process GO:0009161 187 0.500
ribonucleoside catabolic process GO:0042454 406 0.489
ovulation cycle process GO:0022602 9 0.483
ribonucleoside triphosphate metabolic process GO:0009199 412 0.451
purine ribonucleoside metabolic process GO:0046128 437 0.445
regulation of kinase activity GO:0043549 314 0.444
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.442
positive regulation of endopeptidase activity GO:0010950 84 0.427
nucleoside phosphate catabolic process GO:1901292 412 0.423
mitotic cell cycle process GO:1903047 286 0.411
nucleoside triphosphate metabolic process GO:0009141 422 0.409
purine ribonucleotide catabolic process GO:0009154 404 0.405
purine containing compound catabolic process GO:0072523 411 0.397
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.387
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 10 0.376
lens development in camera type eye GO:0002088 2 0.375
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.352
protein dna complex assembly GO:0065004 64 0.346
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.342
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.312
protein dna complex subunit organization GO:0071824 80 0.309
regulation of mitosis GO:0007088 63 0.301
regulation of cellular ketone metabolic process GO:0010565 50 0.271
protein modification by small protein conjugation GO:0032446 342 0.262
Fly
female gamete generation GO:0007292 2 0.258
chromatin remodeling GO:0006338 55 0.255
regulation of dna templated transcription initiation GO:2000142 9 0.246
regulation of cell cycle GO:0051726 393 0.242
regulation of protein complex assembly GO:0043254 147 0.239
mitotic cell cycle GO:0000278 326 0.236
purine ribonucleoside catabolic process GO:0046130 398 0.231
nucleotide catabolic process GO:0009166 408 0.228
response to nitrogen compound GO:1901698 184 0.225
negative regulation of endopeptidase activity GO:0010951 84 0.220
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.216
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 4 0.205
positive regulation of cell growth GO:0030307 48 0.203
dna templated transcription elongation GO:0006354 25 0.202
oocyte differentiation GO:0009994 2 0.201
reproduction GO:0000003 63 0.201
Worm
double strand break repair GO:0006302 101 0.198
cytokine production GO:0001816 247 0.195
nucleoside monophosphate catabolic process GO:0009125 159 0.190
multicellular organism reproduction GO:0032504 42 0.187
Worm
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.186
mitotic spindle organization GO:0007052 27 0.181
regulation of immune response GO:0050776 201 0.167
purine nucleoside catabolic process GO:0006152 398 0.163
posttranscriptional gene silencing by rna GO:0035194 25 0.163
Worm
nuclear division GO:0000280 128 0.163
negative regulation of response to external stimulus GO:0032102 83 0.162
purine nucleotide catabolic process GO:0006195 405 0.158
response to organonitrogen compound GO:0010243 156 0.152
positive regulation of cellular component organization GO:0051130 376 0.151
organophosphate catabolic process GO:0046434 430 0.150
chemical homeostasis GO:0048878 306 0.149
gene silencing GO:0016458 49 0.142
Worm
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.142
regulation of mitotic cell cycle GO:0007346 189 0.141
ribonucleotide catabolic process GO:0009261 405 0.141
regulation of cell growth GO:0001558 135 0.140
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.134
growth GO:0040007 202 0.132
double strand break repair via homologous recombination GO:0000724 50 0.131
hematopoietic or lymphoid organ development GO:0048534 186 0.129
cell division GO:0051301 168 0.125
regulation of defense response GO:0031347 154 0.124
cell activation GO:0001775 213 0.121
posttranscriptional gene silencing GO:0016441 25 0.120
Worm
regulation of cellular amine metabolic process GO:0033238 11 0.118
glycosyl compound catabolic process GO:1901658 413 0.118
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.115
Fly
intermediate filament cytoskeleton organization GO:0045104 17 0.115
brain morphogenesis GO:0048854 1 0.114
regulation of dna templated transcription elongation GO:0032784 23 0.110
metaphase anaphase transition of cell cycle GO:0044784 21 0.106
epithelial cell development GO:0002064 34 0.101
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.100
chromosome separation GO:0051304 23 0.099
purine nucleoside triphosphate catabolic process GO:0009146 392 0.098
spindle organization GO:0007051 53 0.098
meiosis i GO:0007127 4 0.096
regulation of mitochondrion organization GO:0010821 54 0.091
positive regulation of hydrolase activity GO:0051345 331 0.090
regulation of leukocyte differentiation GO:1902105 61 0.089
molting cycle GO:0042303 28 0.089
ovulation cycle GO:0042698 9 0.086
head development GO:0060322 108 0.085
immune system development GO:0002520 195 0.085
regulation of dna replication GO:0006275 68 0.082
regulation of cellular amino acid metabolic process GO:0006521 6 0.081
cellular ketone metabolic process GO:0042180 80 0.080
positive regulation of dna templated transcription initiation GO:2000144 5 0.079
viral life cycle GO:0019058 132 0.078
positive regulation of cellular component biogenesis GO:0044089 158 0.074
regulation of cell differentiation GO:0045595 393 0.073
regulation of response to external stimulus GO:0032101 222 0.072
purine nucleoside triphosphate metabolic process GO:0009144 412 0.072
regulation of protein deubiquitination GO:0090085 4 0.072
chromatin organization GO:0006325 351 0.071
cell growth GO:0016049 160 0.071
leukocyte activation GO:0045321 164 0.068
positive regulation of protein complex assembly GO:0031334 86 0.066
cellular response to nitrogen compound GO:1901699 144 0.066
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.066
cellular response to peptide GO:1901653 59 0.066
lymphocyte activation GO:0046649 133 0.064
negative regulation of hydrolase activity GO:0051346 182 0.064
negative regulation of phosphate metabolic process GO:0045936 267 0.063
sensory organ development GO:0007423 52 0.062
negative regulation of hydrogen peroxide induced cell death GO:1903206 9 0.062
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.061
mitotic nuclear division GO:0007067 119 0.059
regulation of cell division GO:0051302 116 0.058
negative regulation of proteolysis GO:0045861 132 0.058
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.057
chordate embryonic development GO:0043009 34 0.056
negative regulation of cellular amine metabolic process GO:0033239 3 0.056
regulation of protein maturation GO:1903317 150 0.056
secretion GO:0046903 254 0.055
posttranscriptional regulation of gene expression GO:0010608 213 0.054
Worm
chromatin modification GO:0016568 298 0.054
central nervous system development GO:0007417 123 0.054
er associated misfolded protein catabolic process GO:0071712 1 0.053
cell cycle checkpoint GO:0000075 117 0.052
positive regulation of protein phosphorylation GO:0001934 313 0.052
signal transduction by phosphorylation GO:0023014 297 0.051
cellular amine metabolic process GO:0044106 41 0.051
positive regulation of protein ubiquitination GO:0031398 53 0.049
regulation of exit from mitosis GO:0007096 6 0.049
cell cell signaling GO:0007267 155 0.048
oocyte development GO:0048599 1 0.048
response to peptide GO:1901652 65 0.046
brain development GO:0007420 97 0.045
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 8 0.045
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.045
negative regulation of apoptotic process GO:0043066 316 0.044
regulation of growth GO:0040008 165 0.043
leukocyte differentiation GO:0002521 98 0.043
double strand break repair via nonhomologous end joining GO:0006303 10 0.043
female gonad development GO:0008585 10 0.043
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.042
secretion by cell GO:0032940 226 0.042
regulation of t cell differentiation in thymus GO:0033081 2 0.041
non recombinational repair GO:0000726 14 0.041
mitochondrion organization GO:0007005 156 0.041
g protein coupled receptor signaling pathway GO:0007186 207 0.041
spermatogenesis GO:0007283 22 0.039
Worm
negative regulation of response to wounding GO:1903035 47 0.039
mitotic sister chromatid segregation GO:0000070 53 0.038
regulation of ubiquitin protein transferase activity GO:0051438 28 0.038
platelet derived growth factor receptor signaling pathway GO:0048008 14 0.037
connective tissue development GO:0061448 39 0.037
mapk cascade GO:0000165 288 0.035
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.034
midbrain development GO:0030901 45 0.034
positive regulation of phosphorylation GO:0042327 394 0.034
negative regulation of cellular protein metabolic process GO:0032269 353 0.033
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.033
hemopoiesis GO:0030097 180 0.032
multi organism cellular process GO:0044764 156 0.032
ribonucleoside triphosphate catabolic process GO:0009203 391 0.032
negative regulation of protein modification process GO:0031400 200 0.032
regulation of cell cycle process GO:0010564 266 0.032
neurogenesis GO:0022008 169 0.032
recombinational repair GO:0000725 50 0.031
negative regulation of phosphorus metabolic process GO:0010563 267 0.031
t cell activation GO:0042110 99 0.031
sperm egg recognition GO:0035036 3 0.030
negative regulation of intracellular signal transduction GO:1902532 183 0.030
viral process GO:0016032 146 0.029
regulation of transferase activity GO:0051338 355 0.029
negative regulation of protein metabolic process GO:0051248 391 0.028
associative learning GO:0008306 1 0.028
regulation of sister chromatid segregation GO:0033045 27 0.028
immune response GO:0006955 307 0.028
amine metabolic process GO:0009308 44 0.028
regulation of cellular response to stress GO:0080135 244 0.027
spindle assembly GO:0051225 29 0.027
lens fiber cell differentiation GO:0070306 2 0.027
cell development GO:0048468 328 0.026
response to oxygen containing compound GO:1901700 369 0.026
regulation of protein transport GO:0051223 213 0.026
response to wounding GO:0009611 168 0.026
mitotic cell cycle phase transition GO:0044772 162 0.026
neurotransmitter secretion GO:0007269 4 0.026
regulation of cell activation GO:0050865 125 0.025
regulation of nucleoside metabolic process GO:0009118 209 0.025
osteoblast differentiation GO:0001649 92 0.025
rrna catabolic process GO:0016075 6 0.025
regulation of gene expression epigenetic GO:0040029 73 0.025
Worm
negative regulation of growth GO:0045926 97 0.025
regulation of cysteine type endopeptidase activity GO:2000116 127 0.025
mitochondrial fission GO:0000266 14 0.025
negative regulation of protein acetylation GO:1901984 11 0.024
endocytosis GO:0006897 159 0.023
dna templated transcriptional preinitiation complex assembly GO:0070897 5 0.023
positive regulation of kinase activity GO:0033674 204 0.023
negative regulation of protein maturation GO:1903318 142 0.022
inclusion body assembly GO:0070841 17 0.022
gonad development GO:0008406 34 0.022
negative regulation of mapk cascade GO:0043409 56 0.022
telencephalon development GO:0021537 17 0.022
i kappab kinase nf kappab signaling GO:0007249 166 0.022
reciprocal meiotic recombination GO:0007131 4 0.022
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.022
inflammatory response to antigenic stimulus GO:0002437 4 0.022
negative regulation of kinase activity GO:0033673 106 0.021
negative regulation of protein processing GO:0010955 142 0.021
hormone metabolic process GO:0042445 61 0.021
ventricular system development GO:0021591 1 0.021
tube development GO:0035295 125 0.020
microtubule organizing center organization GO:0031023 62 0.020
protein processing GO:0016485 226 0.020
positive regulation of secretion GO:0051047 116 0.019
defense response GO:0006952 315 0.019
regulation of inclusion body assembly GO:0090083 13 0.019
negative regulation of inflammatory response GO:0050728 22 0.019
establishment of apical basal cell polarity GO:0035089 1 0.019
regulation of t cell activation GO:0050863 77 0.019
regulation of viral process GO:0050792 103 0.018
regulation of secretion by cell GO:1903530 177 0.018
centrosome organization GO:0051297 58 0.018
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 13 0.018
tissue morphogenesis GO:0048729 96 0.018
apoptotic mitochondrial changes GO:0008637 57 0.018
forebrain development GO:0030900 26 0.018
mitotic cytokinetic process GO:1902410 2 0.017
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.017
nitrogen compound transport GO:0071705 191 0.017
negative regulation of defense response GO:0031348 47 0.017
gland development GO:0048732 48 0.017
positive regulation of nucleotide catabolic process GO:0030813 185 0.017
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.017
regulation of viral genome replication GO:0045069 48 0.016
protein stabilization GO:0050821 64 0.016
regulation of cytoplasmic transport GO:1903649 149 0.016
negative regulation of multicellular organismal process GO:0051241 317 0.016
Worm
anatomical structure homeostasis GO:0060249 100 0.016
response to hormone GO:0009725 175 0.015
maintenance of protein location in cell GO:0032507 56 0.015
cellular amino acid metabolic process GO:0006520 116 0.015
cellular response to endogenous stimulus GO:0071495 336 0.015
regulation of protein kinase activity GO:0045859 289 0.015
positive regulation of viral process GO:0048524 37 0.014
protein k48 linked deubiquitination GO:0071108 19 0.014
apoptotic signaling pathway GO:0097190 268 0.014
meiotic chromosome segregation GO:0045132 4 0.014
cellular response to hormone stimulus GO:0032870 125 0.014
monoubiquitinated histone deubiquitination GO:0035521 3 0.014
positive regulation of cell differentiation GO:0045597 211 0.013
negative regulation of epithelial cell migration GO:0010633 38 0.013
vesicle organization GO:0016050 62 0.013
receptor mediated endocytosis GO:0006898 84 0.013
intrinsic apoptotic signaling pathway GO:0097193 127 0.013
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.013
regulation of membrane potential GO:0042391 95 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
regulation of nucleocytoplasmic transport GO:0046822 98 0.013
regulation of carbohydrate metabolic process GO:0006109 54 0.013
negative regulation of transferase activity GO:0051348 124 0.013
positive regulation of multi organism process GO:0043902 56 0.013
vasculature development GO:0001944 181 0.013
t cell differentiation in thymus GO:0033077 4 0.012
protein localization to organelle GO:0033365 280 0.012
covalent chromatin modification GO:0016569 254 0.012
negative regulation of response to dna damage stimulus GO:2001021 33 0.012
cellular response to topologically incorrect protein GO:0035967 19 0.012
regulation of nf kappab import into nucleus GO:0042345 22 0.012
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.012
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.012
rna interference GO:0016246 4 0.012
Worm
epidermal growth factor receptor signaling pathway GO:0007173 39 0.012
spindle assembly involved in mitosis GO:0090307 12 0.012
nuclear import GO:0051170 106 0.012
thymus development GO:0048538 3 0.011
behavior GO:0007610 112 0.011
regulation of protein processing GO:0070613 150 0.011
lymphocyte differentiation GO:0030098 35 0.011
positive regulation of nucleotide metabolic process GO:0045981 230 0.010
regulation of neuron projection development GO:0010975 57 0.010
response to organic cyclic compound GO:0014070 204 0.010
positive regulation of cell cycle GO:0045787 140 0.010

PSMD4 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.038
nervous system disease DOID:863 431 0.038
neurodegenerative disease DOID:1289 102 0.018
xeroderma pigmentosum DOID:0050427 8 0.012