Homo sapiens

69 known processes

PTBP1

polypyrimidine tract binding protein 1

(Aliases: PTB-1,PTB-T,MGC10830,HNRPI,PTB,HNRNPI,pPTB,HNRNP-I,PTB4,PTB2,PTB3,MGC8461)

PTBP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna processing GO:0006396 255 0.999
mrna metabolic process GO:0016071 175 0.999
regulation of mrna splicing via spliceosome GO:0048024 32 0.998
negative regulation of rna splicing GO:0033119 15 0.997
rna splicing GO:0008380 131 0.987
regulation of mrna metabolic process GO:1903311 53 0.972
mrna splicing via spliceosome GO:0000398 89 0.943
oocyte development GO:0048599 1 0.940
Fly
rna stabilization GO:0043489 18 0.901
mrna processing GO:0006397 133 0.898
oocyte differentiation GO:0009994 2 0.874
Fly
regulation of alternative mrna splicing via spliceosome GO:0000381 22 0.872
regulation of rna splicing GO:0043484 62 0.842
oogenesis GO:0048477 2 0.814
Fly
regulation of mrna processing GO:0050684 48 0.763
regulation of circadian rhythm GO:0042752 11 0.731
negative regulation of mrna metabolic process GO:1903312 15 0.694
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.593
Fly
mesenchyme development GO:0060485 59 0.573
circadian regulation of translation GO:0097167 1 0.566
female gamete generation GO:0007292 2 0.546
Fly
stem cell development GO:0048864 69 0.531
rna splicing via transesterification reactions GO:0000375 90 0.527
regulation of cellular response to stress GO:0080135 244 0.522
Fly
regulation of translation GO:0006417 89 0.470
Fly
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.469
negative regulation of mrna splicing via spliceosome GO:0048025 11 0.466
mesenchymal cell differentiation GO:0048762 52 0.446
ribonucleoprotein complex biogenesis GO:0022613 116 0.415
positive regulation of developmental process GO:0051094 314 0.387
regulation of cell differentiation GO:0045595 393 0.367
multicellular organismal aging GO:0010259 3 0.355
microtubule cytoskeleton organization GO:0000226 176 0.339
Fly
anatomical structure formation involved in morphogenesis GO:0048646 284 0.330
Fly
translation GO:0006412 132 0.308
Fly
mesenchymal cell development GO:0014031 50 0.298
pattern specification process GO:0007389 43 0.291
Zebrafish Fly
mrna stabilization GO:0048255 18 0.278
regulation of cell cycle process GO:0010564 266 0.269
post embryonic development GO:0009791 2 0.247
Fly
intracellular mrna localization GO:0008298 1 0.223
blastoderm segmentation GO:0007350 2 0.215
cell development GO:0048468 328 0.212
Fly
anterior posterior axis specification GO:0009948 2 0.204
segmentation GO:0035282 4 0.201
neuron differentiation GO:0030182 138 0.195
nuclear export GO:0051168 69 0.188
regulation of response to dna damage stimulus GO:2001020 94 0.183
Fly
cell morphogenesis involved in differentiation GO:0000904 144 0.177
vesicle mediated transport GO:0016192 371 0.174
Zebrafish
determination of adult lifespan GO:0008340 2 0.174
negative regulation of cell death GO:0060548 345 0.171
negative regulation of multi organism process GO:0043901 92 0.167
Zebrafish
cellular component morphogenesis GO:0032989 314 0.162
negative regulation of programmed cell death GO:0043069 321 0.156
embryo development GO:0009790 123 0.148
anterior posterior axis specification embryo GO:0008595 2 0.141
intracellular estrogen receptor signaling pathway GO:0030520 23 0.134
cellular macromolecule catabolic process GO:0044265 380 0.132
regulation of multi organism process GO:0043900 157 0.132
Zebrafish
regulation of rna stability GO:0043487 23 0.130
definitive hemopoiesis GO:0060216 2 0.128
reproductive process GO:0022414 106 0.127
Zebrafish Fly
3 utr mediated mrna stabilization GO:0070935 8 0.124
cytoplasmic transport GO:0016482 379 0.116
posttranscriptional regulation of gene expression GO:0010608 213 0.116
Fly
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.113
development of primary sexual characteristics GO:0045137 35 0.112
alternative mrna splicing via spliceosome GO:0000380 27 0.111
single organism reproductive process GO:0044702 98 0.097
Zebrafish Fly
negative regulation of mrna processing GO:0050686 12 0.092
rhythmic process GO:0048511 31 0.087
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.086
Fly
mrna 3 end processing GO:0031124 24 0.084
dna integrity checkpoint GO:0031570 71 0.083
developmental process involved in reproduction GO:0003006 66 0.078
Fly
stem cell differentiation GO:0048863 93 0.077
rna catabolic process GO:0006401 71 0.076
neuron projection development GO:0031175 106 0.075
regulation of cell cycle phase transition GO:1901987 126 0.075
positive regulation of translation GO:0045727 35 0.073
cellular component assembly involved in morphogenesis GO:0010927 73 0.073
striated muscle cell development GO:0055002 27 0.071
nervous system development GO:0007399 293 0.071
multicellular organismal reproductive process GO:0048609 40 0.069
Fly
striated muscle myosin thick filament assembly GO:0071688 2 0.065
response to abiotic stimulus GO:0009628 336 0.065
single organism cellular localization GO:1902580 332 0.064
cardiovascular system development GO:0072358 262 0.062
reproductive structure development GO:0048608 55 0.062
circadian rhythm GO:0007623 21 0.061
chemotaxis GO:0006935 157 0.060
developmental maturation GO:0021700 28 0.060
Fly
regulation of mitotic cell cycle GO:0007346 189 0.059
axon regeneration GO:0031103 1 0.059
regulation of mrna stability GO:0043488 23 0.058
regulation of cell cycle GO:0051726 393 0.058
adult locomotory behavior GO:0008344 1 0.058
cell morphogenesis GO:0000902 296 0.057
negative regulation of cell differentiation GO:0045596 171 0.056
central nervous system development GO:0007417 123 0.056
epithelial cell differentiation GO:0030855 141 0.056
muscle structure development GO:0061061 98 0.055
generation of neurons GO:0048699 152 0.055
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.053
tube development GO:0035295 125 0.052
mitotic cell cycle process GO:1903047 286 0.052
taxis GO:0042330 157 0.051
adult behavior GO:0030534 18 0.048
rna localization GO:0006403 41 0.048
cell cell signaling GO:0007267 155 0.047
cellular response to dna damage stimulus GO:0006974 379 0.047
Fly
nitrogen compound transport GO:0071705 191 0.046
axon development GO:0061564 34 0.045
myosin filament assembly GO:0031034 2 0.045
sensory perception of light stimulus GO:0050953 35 0.040
tripartite regional subdivision GO:0007351 2 0.039
cell aging GO:0007569 52 0.039
behavior GO:0007610 112 0.038
regulation of cell aging GO:0090342 18 0.038
embryonic morphogenesis GO:0048598 85 0.037
rna 3 end processing GO:0031123 35 0.036
striated muscle cell differentiation GO:0051146 43 0.036
sexual reproduction GO:0019953 37 0.036
Zebrafish Fly
regulation of cell development GO:0060284 161 0.036
osteoblast differentiation GO:0001649 92 0.036
negative regulation of cell cycle process GO:0010948 121 0.035
dna damage checkpoint GO:0000077 68 0.034
cell cycle phase transition GO:0044770 173 0.033
epithelial to mesenchymal transition GO:0001837 48 0.033
growth GO:0040007 202 0.033
positive regulation of nucleobase containing compound transport GO:0032241 1 0.033
regulation of gene expression epigenetic GO:0040029 73 0.033
membrane organization GO:0061024 292 0.032
circulatory system development GO:0072359 262 0.032
reproductive system development GO:0061458 56 0.032
intracellular receptor signaling pathway GO:0030522 104 0.032
microtubule based process GO:0007017 210 0.032
Fly
cation transport GO:0006812 331 0.032
reproduction GO:0000003 63 0.031
Zebrafish Fly
chromatin remodeling GO:0006338 55 0.031
ossification GO:0001503 121 0.030
negative regulation of cell cycle GO:0045786 193 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.028
muscle cell development GO:0055001 29 0.028
modulation by host of viral transcription GO:0043921 20 0.028
regulation of neural precursor cell proliferation GO:2000177 4 0.027
muscle cell differentiation GO:0042692 63 0.027
blood circulation GO:0008015 113 0.027
response to external biotic stimulus GO:0043207 261 0.026
tube morphogenesis GO:0035239 95 0.026
spermatid differentiation GO:0048515 4 0.026
Fly
immune effector process GO:0002252 159 0.026
neurogenesis GO:0022008 169 0.025
dna packaging GO:0006323 77 0.025
circulatory system process GO:0003013 113 0.024
mrna catabolic process GO:0006402 56 0.024
epithelial cell development GO:0002064 34 0.024
hindbrain development GO:0030902 3 0.024
nuclear transcribed mrna catabolic process GO:0000956 48 0.023
maintenance of location GO:0051235 112 0.023
mating GO:0007618 1 0.023
mitotic cell cycle GO:0000278 326 0.023
regulation of neuron projection regeneration GO:0070570 1 0.022
receptor mediated endocytosis GO:0006898 84 0.022
synaptic transmission GO:0007268 61 0.021
visual perception GO:0007601 27 0.021
neural crest cell development GO:0014032 3 0.021
multi organism cellular process GO:0044764 156 0.021
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.021
Fly
microtubule organizing center organization GO:0031023 62 0.021
nucleoside phosphate biosynthetic process GO:1901293 109 0.020
myosin filament organization GO:0031033 2 0.020
response to virus GO:0009615 126 0.020
positive regulation of cell cycle process GO:0090068 106 0.020
somatic muscle development GO:0007525 1 0.020
negative regulation of intracellular signal transduction GO:1902532 183 0.019
locomotory behavior GO:0007626 1 0.019
dna repair GO:0006281 198 0.019
organelle localization GO:0051640 84 0.018
aging GO:0007568 66 0.018
endocytosis GO:0006897 159 0.018
multicellular organism reproduction GO:0032504 42 0.018
Fly
positive regulation of transport GO:0051050 336 0.018
Zebrafish
nuclear migration GO:0007097 1 0.017
axonogenesis GO:0007409 31 0.017
axis specification GO:0009798 12 0.017
Fly
tissue morphogenesis GO:0048729 96 0.017
connective tissue development GO:0061448 39 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
protein dna complex assembly GO:0065004 64 0.016
nucleotide biosynthetic process GO:0009165 109 0.016
positive regulation of oxidative stress induced cell death GO:1903209 5 0.015
defense response to virus GO:0051607 71 0.015
negative regulation of response to external stimulus GO:0032102 83 0.015
germ cell development GO:0007281 8 0.015
Fly
cell part morphogenesis GO:0032990 137 0.015
establishment of nucleus localization GO:0040023 1 0.015
nucleobase containing compound transport GO:0015931 51 0.014
lens development in camera type eye GO:0002088 2 0.014
defense response GO:0006952 315 0.014
semaphorin plexin signaling pathway GO:0071526 4 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
cellular response to oxidative stress GO:0034599 85 0.014
response to temperature stimulus GO:0009266 22 0.014
positive regulation of immune system process GO:0002684 283 0.014
dephosphorylation GO:0016311 209 0.013
chromatin organization GO:0006325 351 0.013
photoreceptor cell differentiation GO:0046530 2 0.013
regulation of astrocyte differentiation GO:0048710 3 0.013
protein targeting GO:0006605 187 0.013
regulation of plasma lipoprotein particle levels GO:0097006 32 0.013
response to other organism GO:0051707 261 0.013
carbohydrate derivative biosynthetic process GO:1901137 207 0.013
establishment or maintenance of cell polarity GO:0007163 31 0.012
Fly
gliogenesis GO:0042063 21 0.012
organelle assembly GO:0070925 176 0.012
lymphocyte activation GO:0046649 133 0.012
gamete generation GO:0007276 25 0.012
Fly
cell junction assembly GO:0034329 67 0.012
establishment of rna localization GO:0051236 39 0.012
cell projection organization GO:0030030 252 0.012
response to axon injury GO:0048678 1 0.012
regulation of binding GO:0051098 111 0.012
secretion by cell GO:0032940 226 0.011
Zebrafish
gene silencing GO:0016458 49 0.011
cartilage development GO:0051216 31 0.011
protein catabolic process GO:0030163 325 0.011
regulation of protein localization GO:0032880 296 0.011
heart development GO:0007507 95 0.011
glial cell migration GO:0008347 4 0.010
detection of stimulus GO:0051606 85 0.010
regulation of axon regeneration GO:0048679 1 0.010
lipid transport GO:0006869 90 0.010
cofactor metabolic process GO:0051186 87 0.010
regulation of mitotic cell cycle phase transition GO:1901990 118 0.010

PTBP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
diabetes mellitus DOID:9351 31 0.271
type 2 diabetes mellitus DOID:9352 28 0.271
disease of metabolism DOID:0014667 295 0.271
carbohydrate metabolism disease DOID:0050013 32 0.271
glucose metabolism disease DOID:4194 32 0.271
acquired metabolic disease DOID:0060158 58 0.271
cancer DOID:162 167 0.019
disease of cellular proliferation DOID:14566 174 0.019
central nervous system disease DOID:331 186 0.012
nervous system disease DOID:863 431 0.012
neurodegenerative disease DOID:1289 102 0.011