|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.993
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.990
|
|
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
0.973
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.957
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.954
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.951
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.946
|
|
|
|
regulation of blood vessel size
|
GO:0050880 |
18 |
0.944
|
|
|
|
dopamine receptor signaling pathway
|
GO:0007212 |
10 |
0.934
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.929
|
|
|
|
regulation of tube size
|
GO:0035150 |
18 |
0.927
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.922
|
Fly |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.913
|
Mouse |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.910
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.910
|
Mouse Rat |
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.901
|
Mouse |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.897
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.895
|
|
|
|
amino acid betaine transport
|
GO:0015838 |
4 |
0.884
|
|
|
|
negative regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014067 |
4 |
0.882
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.876
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.863
|
Worm |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.860
|
Rat Fly |
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.856
|
|
|
|
negative regulation of insulin secretion involved in cellular response to glucose stimulus
|
GO:0061179 |
1 |
0.854
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.853
|
Rat Fly |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.848
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.837
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.836
|
|
|
|
adenylate cyclase activating dopamine receptor signaling pathway
|
GO:0007191 |
3 |
0.814
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.798
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.797
|
|
|
|
phospholipase c activating g protein coupled receptor signaling pathway
|
GO:0007200 |
15 |
0.796
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.785
|
Mouse Fly |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.785
|
Mouse |
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.785
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.773
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.773
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.761
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.758
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.750
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.749
|
Rat Worm |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.744
|
Mouse Rat |
|
|
regulation of hemostasis
|
GO:1900046 |
42 |
0.743
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.740
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.738
|
Fly |
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.734
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.732
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.725
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.725
|
Rat Fly |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.723
|
Rat |
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
43 |
0.722
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.720
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.710
|
Mouse |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.706
|
Mouse |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.696
|
Mouse |
|
|
adenylate cyclase inhibiting adrenergic receptor signaling pathway
|
GO:0071881 |
1 |
0.695
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.682
|
Worm |
|
|
system process
|
GO:0003008 |
349 |
0.681
|
Mouse Rat Worm |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.669
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.667
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.665
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.661
|
|
|
|
regulation of cyclase activity
|
GO:0031279 |
19 |
0.660
|
|
|
|
negative regulation of protein kinase b signaling
|
GO:0051898 |
17 |
0.654
|
|
|
|
receptor internalization
|
GO:0031623 |
43 |
0.652
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.648
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.645
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.638
|
Fly |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.635
|
Mouse |
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.634
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.632
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.618
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.618
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.613
|
Fly |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.604
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.602
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.595
|
|
|
|
memory
|
GO:0007613 |
3 |
0.589
|
Rat |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.578
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.576
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.569
|
|
|
|
regulation of the force of heart contraction
|
GO:0002026 |
6 |
0.566
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.563
|
Mouse |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.562
|
Mouse Rat |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.561
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.560
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.559
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.554
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.551
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.545
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.545
|
Rat |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.540
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.536
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.535
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.535
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.534
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.533
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.531
|
|
|
|
phospholipase c activating dopamine receptor signaling pathway
|
GO:0060158 |
2 |
0.529
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.526
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.520
|
Mouse |
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.515
|
Rat |
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.514
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.513
|
Mouse Rat Worm |
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.512
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.510
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.508
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.497
|
Mouse |
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.493
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.493
|
Mouse |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.482
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.480
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.471
|
Worm |
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.467
|
Mouse Worm |
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.464
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.464
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.463
|
Rat |
|
|
wound healing
|
GO:0042060 |
115 |
0.459
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.458
|
|
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.455
|
|
|
|
positive regulation of calcium ion transport into cytosol
|
GO:0010524 |
20 |
0.453
|
|
|
|
positive regulation of endothelial cell proliferation
|
GO:0001938 |
37 |
0.446
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.442
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.439
|
|
|
|
sodium ion homeostasis
|
GO:0055078 |
14 |
0.439
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.434
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.432
|
|
|
|
regulation of sensory perception of pain
|
GO:0051930 |
3 |
0.428
|
|
|
|
renal system process
|
GO:0003014 |
25 |
0.428
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.427
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.418
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.413
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.411
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.411
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.410
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.407
|
Mouse Rat |
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.406
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.404
|
Rat Fly |
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.396
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.392
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.391
|
Mouse |
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.390
|
|
|
|
negative regulation of sodium ion transmembrane transporter activity
|
GO:2000650 |
2 |
0.390
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.382
|
Zebrafish Mouse Rat Fly |
|
|
parturition
|
GO:0007567 |
1 |
0.382
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.381
|
Zebrafish Mouse |
|
|
multicellular organismal homeostasis
|
GO:0048871 |
67 |
0.381
|
|
|
|
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway
|
GO:0051482 |
6 |
0.380
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.377
|
Fly |
|
|
response to hormone
|
GO:0009725 |
175 |
0.373
|
Rat Fly |
|
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.370
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.369
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.367
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.361
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.360
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.360
|
Zebrafish Mouse |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.359
|
Mouse Fly |
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.358
|
|
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.357
|
|
|
|
positive regulation of multicellular organismal metabolic process
|
GO:0044253 |
11 |
0.353
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.353
|
|
|
|
regulation of coagulation
|
GO:0050818 |
44 |
0.351
|
|
|
|
regulation of blood coagulation
|
GO:0030193 |
42 |
0.350
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.348
|
Mouse Rat Worm |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.348
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.347
|
|
|
|
regulation of multicellular organismal metabolic process
|
GO:0044246 |
17 |
0.342
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.342
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.340
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.340
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.336
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.336
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.335
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.334
|
Zebrafish Fly |
|
|
regulation of nuclear division
|
GO:0051783 |
65 |
0.334
|
|
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
61 |
0.333
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.328
|
Rat |
|
|
cytokine production
|
GO:0001816 |
247 |
0.327
|
|
|
|
positive regulation of phospholipase activity
|
GO:0010518 |
22 |
0.326
|
|
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.318
|
Worm |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.317
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.313
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.312
|
|
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.310
|
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.306
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.302
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.302
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.300
|
Fly |
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.298
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.294
|
Fly |
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.294
|
|
|
|
response to hyperoxia
|
GO:0055093 |
4 |
0.293
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.293
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.289
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.288
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.286
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.286
|
|
|
|
positive regulation of vasoconstriction
|
GO:0045907 |
3 |
0.281
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.281
|
Worm Fly |
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.279
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.278
|
Rat |
|
|
positive regulation of phosphatidylinositol biosynthetic process
|
GO:0010513 |
3 |
0.275
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.274
|
Mouse Fly |
|
|
protein maturation
|
GO:0051604 |
233 |
0.267
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.266
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.265
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.265
|
|
|
|
positive regulation of phosphoprotein phosphatase activity
|
GO:0032516 |
9 |
0.263
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.261
|
|
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.257
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.256
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.253
|
|
|
|
detection of mechanical stimulus
|
GO:0050982 |
4 |
0.252
|
|
|
|
peptide transport
|
GO:0015833 |
74 |
0.250
|
|
|
|
phospholipase c activating adrenergic receptor signaling pathway
|
GO:0071882 |
1 |
0.250
|
|
|
|
response to increased oxygen levels
|
GO:0036296 |
4 |
0.249
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.248
|
|
|
|
caveola assembly
|
GO:0070836 |
4 |
0.247
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.245
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.242
|
Rat |
|
|
vascular process in circulatory system
|
GO:0003018 |
29 |
0.240
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.239
|
|
|
|
lipid transport
|
GO:0006869 |
90 |
0.237
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.236
|
Zebrafish Mouse |
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.234
|
Worm |
|
|
somatic stem cell division
|
GO:0048103 |
1 |
0.234
|
|
|
|
sensory perception
|
GO:0007600 |
103 |
0.233
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.230
|
|
|
|
sensory perception of mechanical stimulus
|
GO:0050954 |
37 |
0.228
|
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.227
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.223
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.221
|
|
|
|
plasma membrane raft assembly
|
GO:0044854 |
4 |
0.221
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.219
|
|
|
|
positive regulation of blood circulation
|
GO:1903524 |
12 |
0.218
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.217
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.217
|
Mouse Rat Fly |
|
|
negative regulation of jak stat cascade
|
GO:0046426 |
4 |
0.216
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.214
|
Mouse Rat Fly |
|
|
negative regulation of nucleotide biosynthetic process
|
GO:0030809 |
11 |
0.211
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.211
|
|
|
|
regulation of receptor mediated endocytosis
|
GO:0048259 |
32 |
0.207
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.203
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.202
|
Rat |
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.201
|
|
|
|
positive regulation of metalloenzyme activity
|
GO:0048554 |
2 |
0.201
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.201
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.200
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.200
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.199
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.198
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.196
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.195
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.194
|
|
|
|
serotonin receptor signaling pathway
|
GO:0007210 |
11 |
0.193
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.191
|
Fly |
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
49 |
0.191
|
|
|
|
eye development
|
GO:0001654 |
42 |
0.191
|
Fly |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.190
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.190
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.190
|
|
|
|
receptor internalization involved in canonical wnt signaling pathway
|
GO:2000286 |
3 |
0.189
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.188
|
|
|
|
negative regulation of binding
|
GO:0051100 |
57 |
0.186
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.185
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.184
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.183
|
Zebrafish Fly |
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.183
|
|
|
|
renal response to blood flow involved in circulatory renin angiotensin regulation of systemic arterial blood pressure
|
GO:0001999 |
1 |
0.183
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.182
|
Mouse Fly |
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.182
|
Mouse Worm Fly |
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.180
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.179
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.178
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.176
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.176
|
Mouse |
|
|
single organism behavior
|
GO:0044708 |
28 |
0.175
|
Mouse Rat Worm |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.174
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.174
|
Rat |
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.172
|
Worm |
|
|
reproductive process
|
GO:0022414 |
106 |
0.172
|
Mouse |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.169
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.168
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.168
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.167
|
Fly |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.166
|
Mouse Fly |
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.166
|
|
|
|
negative regulation of protein binding
|
GO:0032091 |
35 |
0.165
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.163
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.161
|
Worm |
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.160
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.160
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.159
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.159
|
|
|
|
negative regulation of nitric oxide biosynthetic process
|
GO:0045019 |
5 |
0.159
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.157
|
|
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.157
|
|
|
|
negative regulation of cyclic nucleotide biosynthetic process
|
GO:0030803 |
10 |
0.156
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.156
|
|
|
|
negative regulation of pinocytosis
|
GO:0048550 |
4 |
0.156
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.154
|
|
|
|
multicellular organismal metabolic process
|
GO:0044236 |
34 |
0.153
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.152
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.151
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.151
|
Mouse |
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.150
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.149
|
|
|
|
regulation of the force of heart contraction by chemical signal
|
GO:0003057 |
1 |
0.149
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.148
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.147
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.145
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.145
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.143
|
Mouse Fly |
|
|
regulation of vascular endothelial growth factor receptor signaling pathway
|
GO:0030947 |
9 |
0.141
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.140
|
Mouse Fly |
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.140
|
Mouse Fly |
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.140
|
Worm |
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.139
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.139
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.138
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.138
|
|
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.138
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.137
|
Zebrafish Fly |
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.136
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.136
|
Mouse |
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.136
|
|
|
|
response to monosaccharide
|
GO:0034284 |
20 |
0.135
|
Rat |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.134
|
|
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.134
|
|
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.133
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.132
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.132
|
Rat |
|
|
anion transport
|
GO:0006820 |
161 |
0.131
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.131
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.130
|
|
|
|
organic hydroxy compound biosynthetic process
|
GO:1901617 |
71 |
0.129
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.129
|
Mouse Fly |
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.128
|
|
|
|
cholesterol transport
|
GO:0030301 |
39 |
0.128
|
|
|
|
positive regulation of vasodilation
|
GO:0045909 |
4 |
0.127
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.127
|
Worm |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.127
|
|
|
|
negative regulation of reactive oxygen species biosynthetic process
|
GO:1903427 |
1 |
0.126
|
|
|
|
regulation of vasodilation
|
GO:0042312 |
4 |
0.125
|
|
|
|
rostrocaudal neural tube patterning
|
GO:0021903 |
1 |
0.125
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.125
|
Mouse Fly |
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.124
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.124
|
|
|
|
negative regulation of sodium ion transport
|
GO:0010766 |
3 |
0.124
|
|
|
|
negative regulation of tyrosine phosphorylation of stat protein
|
GO:0042532 |
2 |
0.124
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.122
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
44 |
0.121
|
|
|
|
negative regulation of cytokine mediated signaling pathway
|
GO:0001960 |
22 |
0.118
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.118
|
Mouse Fly |
|
|
cellular response to hyperoxia
|
GO:0071455 |
4 |
0.117
|
|
|
|
regulation of camp metabolic process
|
GO:0030814 |
52 |
0.117
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.117
|
Mouse Rat |
|
|
amino acid transport
|
GO:0006865 |
28 |
0.117
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.115
|
|
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.115
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.115
|
|
|
|
regulation of pinocytosis
|
GO:0048548 |
6 |
0.115
|
|
|
|
gland development
|
GO:0048732 |
48 |
0.114
|
Mouse Fly |
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.114
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.114
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.114
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.114
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.114
|
Zebrafish |
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.113
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.113
|
|
|
|
mitotic sister chromatid separation
|
GO:0051306 |
18 |
0.113
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.112
|
Worm |
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.112
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.112
|
|
|
|
positive regulation of release of sequestered calcium ion into cytosol
|
GO:0051281 |
16 |
0.111
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.111
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.110
|
Mouse Fly |
|
|
somitogenesis
|
GO:0001756 |
2 |
0.110
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.109
|
Worm |
|
|
neural tube patterning
|
GO:0021532 |
2 |
0.109
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.109
|
|
|
|
response to acid chemical
|
GO:0001101 |
66 |
0.109
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.109
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.108
|
|
|
|
renal sodium ion transport
|
GO:0003096 |
2 |
0.108
|
|
|
|
cellular response to starvation
|
GO:0009267 |
58 |
0.107
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.107
|
|
|
|
caveolin mediated endocytosis
|
GO:0072584 |
4 |
0.107
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.107
|
Mouse Fly |
|
|
bmp signaling pathway
|
GO:0030509 |
49 |
0.106
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.106
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.106
|
|
|
|
regulation of sensory perception
|
GO:0051931 |
3 |
0.106
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.106
|
Fly |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.105
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.105
|
Zebrafish |
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.105
|
Mouse |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.104
|
Zebrafish |
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.104
|
|
|
|
spinal cord development
|
GO:0021510 |
4 |
0.103
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.103
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.102
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.102
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.102
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.102
|
Fly |
|
|
positive regulation of lipid biosynthetic process
|
GO:0046889 |
22 |
0.101
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.101
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.101
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.100
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.099
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.099
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.099
|
|
|
|
tissue homeostasis
|
GO:0001894 |
63 |
0.099
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.099
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.099
|
Zebrafish |
|
|
digestive system development
|
GO:0055123 |
75 |
0.099
|
Zebrafish |
|
|
negative regulation of lyase activity
|
GO:0051350 |
7 |
0.098
|
|
|
|
intestinal cholesterol absorption
|
GO:0030299 |
4 |
0.097
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.097
|
|
|
|
cgmp metabolic process
|
GO:0046068 |
19 |
0.096
|
|
|
|
regulation of cgmp biosynthetic process
|
GO:0030826 |
4 |
0.096
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.096
|
Rat Fly |
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.096
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.096
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.096
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.096
|
Rat |
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.096
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.096
|
|
|
|
cellular response to acid chemical
|
GO:0071229 |
44 |
0.095
|
|
|
|
s shaped body morphogenesis
|
GO:0072050 |
4 |
0.094
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.094
|
|
|
|
epithelial cell development
|
GO:0002064 |
34 |
0.093
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.092
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.092
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.091
|
|
|
|
regulation of mitotic sister chromatid separation
|
GO:0010965 |
27 |
0.091
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.091
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.091
|
Worm |
|
|
hormone transport
|
GO:0009914 |
68 |
0.090
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.090
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.090
|
Fly |
|
|
vasodilation
|
GO:0042311 |
4 |
0.090
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.089
|
Mouse Rat Fly |
|
|
protein processing
|
GO:0016485 |
226 |
0.089
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.089
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.089
|
Zebrafish Mouse |
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.089
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.088
|
|
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.088
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.088
|
Mouse |
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.086
|
Mouse |
|
|
negative regulation of cgmp metabolic process
|
GO:0030824 |
1 |
0.086
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.085
|
|
|
|
developmental maturation
|
GO:0021700 |
28 |
0.085
|
Mouse Fly |
|
|
plasma membrane raft organization
|
GO:0044857 |
4 |
0.085
|
|
|
|
cyclic nucleotide mediated signaling
|
GO:0019935 |
26 |
0.085
|
|
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.085
|
|
|
|
carbohydrate homeostasis
|
GO:0033500 |
31 |
0.084
|
|
|
|
protein k11 linked ubiquitination
|
GO:0070979 |
24 |
0.084
|
|
|
|
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway
|
GO:0035625 |
4 |
0.084
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.084
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.083
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.083
|
|
|
|
negative regulation of transforming growth factor beta receptor signaling pathway
|
GO:0030512 |
28 |
0.082
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.082
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.082
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.082
|
|
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.082
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.082
|
|
|
|
regulation of sister chromatid segregation
|
GO:0033045 |
27 |
0.081
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.081
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.081
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.080
|
Rat Fly |
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.080
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.080
|
Zebrafish |
|
|
regulation of metalloenzyme activity
|
GO:0048552 |
3 |
0.079
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.079
|
Mouse |
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.079
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
48 |
0.079
|
|
|
|
detection of stimulus involved in sensory perception
|
GO:0050906 |
43 |
0.079
|
|
|
|
skeletal system morphogenesis
|
GO:0048705 |
24 |
0.078
|
|
|
|
regulation of muscle system process
|
GO:0090257 |
53 |
0.078
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.078
|
Worm |
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.078
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.077
|
|
|
|
muscle cell development
|
GO:0055001 |
29 |
0.077
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.076
|
|
|
|
regulation of dopamine receptor signaling pathway
|
GO:0060159 |
3 |
0.076
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.076
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.076
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.075
|
Mouse |
