|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
1.000
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
1.000
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.999
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.996
|
Mouse |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.992
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
23 |
0.992
|
|
|
|
regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042516 |
18 |
0.992
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.991
|
|
|
|
response to insulin
|
GO:0032868 |
45 |
0.987
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.986
|
Mouse |
|
|
response to peptide
|
GO:1901652 |
65 |
0.983
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.981
|
Mouse Fly |
|
|
cell development
|
GO:0048468 |
328 |
0.981
|
Mouse Fly |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.980
|
Mouse |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.979
|
Human Mouse |
|
|
positive regulation of glucose import in response to insulin stimulus
|
GO:2001275 |
3 |
0.978
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.969
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.967
|
Zebrafish Fly |
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.959
|
|
|
|
tyrosine phosphorylation of stat3 protein
|
GO:0042503 |
20 |
0.953
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.950
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.950
|
Mouse |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.948
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.945
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.938
|
Mouse |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.929
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.927
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.923
|
Mouse |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.923
|
Mouse |
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.918
|
Mouse |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.917
|
|
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.915
|
Fly |
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.913
|
Human |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.912
|
Human |
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.909
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.909
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.909
|
Mouse |
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.907
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.906
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.906
|
Fly |
|
|
regulation of cellular response to insulin stimulus
|
GO:1900076 |
17 |
0.904
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.903
|
Human Mouse Fly |
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.901
|
Mouse |
|
|
interleukin 6 mediated signaling pathway
|
GO:0070102 |
7 |
0.900
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
13 |
0.880
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.865
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.864
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.853
|
Mouse |
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.842
|
Human |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.837
|
Mouse |
|
|
response to hormone
|
GO:0009725 |
175 |
0.833
|
|
|
|
positive regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042517 |
16 |
0.831
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.829
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.826
|
Human |
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.821
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.817
|
Mouse |
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.816
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.815
|
Mouse |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.807
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.805
|
|
|
|
regulation of interleukin 6 mediated signaling pathway
|
GO:0070103 |
3 |
0.804
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.795
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.786
|
Mouse Fly |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.780
|
|
|
|
embryonic camera type eye formation
|
GO:0060900 |
2 |
0.776
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.771
|
Human Mouse |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.769
|
Mouse Fly |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.756
|
Human |
|
|
actin filament organization
|
GO:0007015 |
128 |
0.748
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.741
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.729
|
|
|
|
glucose import in response to insulin stimulus
|
GO:0044381 |
4 |
0.718
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.711
|
Mouse |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.704
|
Human Mouse |
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.702
|
Zebrafish Fly |
|
|
behavior
|
GO:0007610 |
112 |
0.699
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.699
|
Mouse |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.699
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.685
|
Fly |
|
|
heart development
|
GO:0007507 |
95 |
0.685
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.684
|
Human Mouse |
|
|
immune response
|
GO:0006955 |
307 |
0.684
|
|
|
|
prostate gland development
|
GO:0030850 |
3 |
0.682
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.656
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.656
|
Fly |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.648
|
Human |
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.636
|
Fly |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.634
|
Fly |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.629
|
Fly |
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.625
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.625
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.599
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.595
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.591
|
|
|
|
lipid localization
|
GO:0010876 |
106 |
0.590
|
Mouse |
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.590
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.586
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.584
|
|
|
|
embryonic camera type eye development
|
GO:0031076 |
2 |
0.565
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.558
|
Fly |
|
|
circulatory system development
|
GO:0072359 |
262 |
0.551
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.540
|
Mouse |
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.537
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.535
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.532
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.530
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.529
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.527
|
Zebrafish |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.524
|
Zebrafish Fly |
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.517
|
Mouse |
|
|
epithelial cell development
|
GO:0002064 |
34 |
0.517
|
Fly |
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.510
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.508
|
Mouse |
|
|
regulation of erbb signaling pathway
|
GO:1901184 |
27 |
0.499
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.496
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.494
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.488
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.480
|
Mouse |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.467
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.466
|
Fly |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.458
|
Human |
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.453
|
|
|
|
growth
|
GO:0040007 |
202 |
0.452
|
Zebrafish Mouse |
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.438
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.435
|
Mouse |
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.434
|
|
|
|
acylglycerol metabolic process
|
GO:0006639 |
27 |
0.424
|
Mouse |
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.421
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.414
|
|
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.409
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.407
|
Mouse |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.406
|
Human |
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.397
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.397
|
Mouse |
|
|
av node cell to bundle of his cell communication
|
GO:0086067 |
4 |
0.395
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.389
|
Human |
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.380
|
Human |
|
|
negative regulation of epidermal growth factor receptor signaling pathway
|
GO:0042059 |
11 |
0.379
|
|
|
|
negative regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042518 |
2 |
0.373
|
|
|
|
cellular extravasation
|
GO:0045123 |
21 |
0.369
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.353
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.353
|
|
|
|
response to interleukin 6
|
GO:0070741 |
15 |
0.353
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.351
|
|
|
|
regulation of glucose import in response to insulin stimulus
|
GO:2001273 |
4 |
0.341
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.338
|
|
|
|
negative regulation of interleukin 6 mediated signaling pathway
|
GO:0070104 |
2 |
0.326
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.312
|
|
|
|
positive regulation of mesenchymal cell proliferation
|
GO:0002053 |
2 |
0.311
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.308
|
Human |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.307
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.299
|
|
|
|
embryonic placenta development
|
GO:0001892 |
1 |
0.297
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.294
|
Zebrafish Fly |
|
|
cell growth
|
GO:0016049 |
160 |
0.294
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
2 |
0.286
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.284
|
Mouse |
|
|
positive regulation of mitotic cell cycle
|
GO:0045931 |
60 |
0.282
|
Mouse |
|
|
membrane organization
|
GO:0061024 |
292 |
0.282
|
Fly |
|
|
nervous system development
|
GO:0007399 |
293 |
0.281
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.279
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.275
|
Mouse |
|
|
erbb signaling pathway
|
GO:0038127 |
44 |
0.271
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.271
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.264
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.257
|
Fly |
|
|
inactivation of mapk activity
|
GO:0000188 |
5 |
0.256
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.250
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.248
|
Zebrafish Fly |
|
|
cellular response to interleukin 6
|
GO:0071354 |
14 |
0.247
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.247
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.246
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.242
|
|
|
|
prostate gland morphogenesis
|
GO:0060512 |
1 |
0.241
|
|
|
|
axonogenesis
|
GO:0007409 |
31 |
0.236
|
Mouse |
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.233
|
Mouse |
|
|
response to uv
|
GO:0009411 |
73 |
0.233
|
|
|
|
carbohydrate transport
|
GO:0008643 |
37 |
0.231
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.230
|
|
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
53 |
0.230
|
|
|
|
eye development
|
GO:0001654 |
42 |
0.229
|
Fly |
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.227
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.227
|
Zebrafish Fly |
|
|
negative regulation of cytokine mediated signaling pathway
|
GO:0001960 |
22 |
0.226
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.222
|
Human |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.220
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.215
|
Fly |
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.213
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.211
|
Human Mouse |
|
|
cation transport
|
GO:0006812 |
331 |
0.209
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.208
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.204
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.202
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.201
|
|
|
|
sensory organ development
|
GO:0007423 |
52 |
0.199
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.198
|
Human |
|
|
eye morphogenesis
|
GO:0048592 |
16 |
0.197
|
Fly |
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.196
|
Mouse |
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.196
|
Fly |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.196
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.195
|
|
|
|
multi multicellular organism process
|
GO:0044706 |
18 |
0.190
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.189
|
Mouse Fly |
|
|
blood vessel development
|
GO:0001568 |
172 |
0.187
|
|
|
|
small molecule catabolic process
|
GO:0044282 |
92 |
0.186
|
|
|
|
platelet derived growth factor receptor signaling pathway
|
GO:0048008 |
14 |
0.185
|
Mouse |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.184
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.182
|
Zebrafish |
|
|
gastrulation
|
GO:0007369 |
51 |
0.182
|
Zebrafish |
|
|
protein polymerization
|
GO:0051258 |
71 |
0.182
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.182
|
Mouse Fly |
|
|
triglyceride metabolic process
|
GO:0006641 |
23 |
0.181
|
Mouse |
|
|
endocytosis
|
GO:0006897 |
159 |
0.180
|
Fly |
|
|
renal system development
|
GO:0072001 |
63 |
0.178
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.173
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.173
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.172
|
Mouse |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.171
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.170
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.169
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.167
|
Mouse |
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.167
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.166
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.165
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.163
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.163
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.163
|
|
|
|
embryonic organ morphogenesis
|
GO:0048562 |
24 |
0.161
|
Zebrafish |
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.160
|
Fly |
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.159
|
Human |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.158
|
Mouse |
|
|
interleukin 27 mediated signaling pathway
|
GO:0070106 |
1 |
0.158
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.156
|
|
|
|
neutral lipid metabolic process
|
GO:0006638 |
27 |
0.155
|
Mouse |
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.154
|
Zebrafish |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.151
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.146
|
Human Mouse |
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.146
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.143
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.141
|
|
|
|
somitogenesis
|
GO:0001756 |
2 |
0.140
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.139
|
|
|
|
negative regulation of map kinase activity
|
GO:0043407 |
27 |
0.139
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.139
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.139
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.138
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.138
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.138
|
|
|
|
negative regulation of jak stat cascade
|
GO:0046426 |
4 |
0.136
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.136
|
|
|
|
cellular carbohydrate metabolic process
|
GO:0044262 |
84 |
0.135
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.135
|
Human |
|
|
mammary gland development
|
GO:0030879 |
17 |
0.132
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.130
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.129
|
Fly |
|
|
lens development in camera type eye
|
GO:0002088 |
2 |
0.128
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.127
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.127
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.127
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.127
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.123
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.123
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.120
|
|
|
|
response to estrogen
|
GO:0043627 |
47 |
0.118
|
|
|
|
gland development
|
GO:0048732 |
48 |
0.118
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.117
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.117
|
|
|
|
regulation of organ formation
|
GO:0003156 |
4 |
0.116
|
|
|
|
ciliary neurotrophic factor mediated signaling pathway
|
GO:0070120 |
5 |
0.114
|
|
|
|
positive regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042523 |
11 |
0.114
|
|
|
|
growth hormone receptor signaling pathway
|
GO:0060396 |
10 |
0.114
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.113
|
|
|
|
morphogenesis of a branching epithelium
|
GO:0061138 |
20 |
0.110
|
|
|
|
type i interferon signaling pathway
|
GO:0060337 |
11 |
0.109
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.109
|
Mouse |
|
|
sensory organ morphogenesis
|
GO:0090596 |
21 |
0.109
|
Fly |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.108
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.107
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.105
|
Mouse |
|
|
negative regulation of wnt signaling pathway
|
GO:0030178 |
69 |
0.105
|
|
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.104
|
|
|
|
vascular endothelial growth factor receptor signaling pathway
|
GO:0048010 |
19 |
0.104
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.102
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.101
|
Zebrafish |
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.099
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.099
|
|
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.099
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.098
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.098
|
Mouse |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.096
|
|
|
|
negative regulation of tyrosine phosphorylation of stat protein
|
GO:0042532 |
2 |
0.096
|
|
|
|
reproductive structure development
|
GO:0048608 |
55 |
0.095
|
|
|
|
multicellular organism reproduction
|
GO:0032504 |
42 |
0.094
|
Mouse Fly |
|
|
negative regulation of cellular carbohydrate metabolic process
|
GO:0010677 |
14 |
0.094
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.094
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.093
|
|
|
|
regulation of atrial cardiac muscle cell membrane depolarization
|
GO:0060371 |
6 |
0.092
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.091
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.091
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.089
|
Human |
|
|
muscle cell differentiation
|
GO:0042692 |
63 |
0.089
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.089
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.089
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.088
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.088
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.088
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.088
|
|
|
|
actin mediated cell contraction
|
GO:0070252 |
12 |
0.088
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.086
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.084
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.083
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.082
|
Mouse |
|
|
embryonic organ development
|
GO:0048568 |
36 |
0.082
|
Zebrafish |
|
|
neuron development
|
GO:0048666 |
113 |
0.082
|
Mouse Fly |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.080
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.080
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.080
|
|
|
|
camera type eye development
|
GO:0043010 |
25 |
0.079
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
11 |
0.079
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.079
|
|
|
|
cellular response to growth hormone stimulus
|
GO:0071378 |
10 |
0.079
|
|
|
|
aging
|
GO:0007568 |
66 |
0.078
|
|
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
20 |
0.078
|
Human |
|
|
regulation of ventricular cardiac muscle cell membrane repolarization
|
GO:0060307 |
10 |
0.078
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.077
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.077
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.076
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.075
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.075
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.074
|
Fly |
|
|
cellular response to hydrogen peroxide
|
GO:0070301 |
37 |
0.074
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.073
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.073
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.072
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.071
|
|
|
|
lipid modification
|
GO:0030258 |
84 |
0.070
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.069
|
|
|
|
negative regulation of insulin receptor signaling pathway
|
GO:0046627 |
8 |
0.069
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.068
|
|
|
|
embryonic camera type eye morphogenesis
|
GO:0048596 |
2 |
0.068
|
|
|
|
ectodermal placode formation
|
GO:0060788 |
1 |
0.067
|
|
|
|
reproductive system development
|
GO:0061458 |
56 |
0.067
|
|
|
|
neural tube formation
|
GO:0001841 |
3 |
0.066
|
|
|
|
cardiac muscle cell action potential involved in contraction
|
GO:0086002 |
21 |
0.066
|
|
|
|
regulation of epidermal growth factor activated receptor activity
|
GO:0007176 |
14 |
0.066
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.065
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.065
|
|
|
|
regulation of nuclear division
|
GO:0051783 |
65 |
0.065
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.065
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.064
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.063
|
|
|
|
regulation of blood vessel size
|
GO:0050880 |
18 |
0.063
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.063
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.062
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.062
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.062
|
|
|
|
response to hydrogen peroxide
|
GO:0042542 |
40 |
0.062
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.061
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.060
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.060
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.059
|
|
|
|
cellular glucan metabolic process
|
GO:0006073 |
22 |
0.059
|
|
|
|
negative regulation of endothelial cell proliferation
|
GO:0001937 |
20 |
0.058
|
|
|
|
memory
|
GO:0007613 |
3 |
0.058
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.058
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.057
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.057
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.057
|
|
|
|
muscle cell development
|
GO:0055001 |
29 |
0.056
|
|
|
|
regulation of receptor activity
|
GO:0010469 |
47 |
0.056
|
|
|
|
melanin metabolic process
|
GO:0006582 |
1 |
0.056
|
|
|
|
ear development
|
GO:0043583 |
14 |
0.056
|
|
|
|
gastrulation with mouth forming second
|
GO:0001702 |
1 |
0.056
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.055
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.054
|
Zebrafish |
|
|
hydrogen peroxide catabolic process
|
GO:0042744 |
13 |
0.054
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.054
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.054
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.053
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.053
|
|
|
|
negative regulation of b cell receptor signaling pathway
|
GO:0050859 |
2 |
0.053
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.053
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.053
|
|
|
|
epidermal growth factor receptor signaling pathway
|
GO:0007173 |
39 |
0.052
|
Mouse Fly |
|
|
humoral immune response
|
GO:0006959 |
49 |
0.052
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.052
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.051
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.051
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.050
|
Mouse |
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.049
|
|
|
|
embryonic eye morphogenesis
|
GO:0048048 |
2 |
0.049
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.049
|
Mouse |
|
|
organ induction
|
GO:0001759 |
4 |
0.049
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.048
|
Mouse |
|
|
monocyte extravasation
|
GO:0035696 |
1 |
0.048
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.048
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.047
|
|
|
|
fibroblast growth factor receptor signaling pathway
|
GO:0008543 |
26 |
0.047
|
Fly |
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.047
|
Mouse |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.047
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
67 |
0.047
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.047
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.047
|
|
|
|
morphogenesis of a branching structure
|
GO:0001763 |
21 |
0.046
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.046
|
Human |
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.046
|
|
|
|
regulation of tor signaling
|
GO:0032006 |
30 |
0.046
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.046
|
|
|
|
stem cell proliferation
|
GO:0072089 |
25 |
0.046
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.046
|
|
|
|
neutrophil extravasation
|
GO:0072672 |
2 |
0.045
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.045
|
|
|
|
regulation of vascular endothelial growth factor receptor signaling pathway
|
GO:0030947 |
9 |
0.045
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
14 |
0.045
|
|
|
|
oncostatin m mediated signaling pathway
|
GO:0038165 |
3 |
0.045
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.044
|
|
|
|
regulation of glucose import
|
GO:0046324 |
21 |
0.044
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.044
|
|
|
|
embryo development ending in birth or egg hatching
|
GO:0009792 |
34 |
0.044
|
Zebrafish |
|
|
circadian sleep wake cycle process
|
GO:0022410 |
2 |
0.044
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.043
|
|
|
|
organ formation
|
GO:0048645 |
3 |
0.043
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.043
|
|
|
|
tissue remodeling
|
GO:0048771 |
16 |
0.043
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.043
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.043
|
Fly |
|
|
positive regulation of insulin receptor signaling pathway
|
GO:0046628 |
3 |
0.043
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.043
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.042
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.042
|
Zebrafish Mouse |
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.041
|
|
|
|
regulation of branching involved in salivary gland morphogenesis by mesenchymal epithelial signaling
|
GO:0060665 |
1 |
0.041
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.041
|
Mouse |
|
|
response to transition metal nanoparticle
|
GO:1990267 |
29 |
0.040
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.040
|
|
|
|
regionalization
|
GO:0003002 |
29 |
0.040
|
Fly |
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.039
|
|
|
|
adult behavior
|
GO:0030534 |
18 |
0.039
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.039
|
|
|
|
camera type eye morphogenesis
|
GO:0048593 |
12 |
0.039
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.038
|
Mouse |
|
|
regulation of cellular carbohydrate metabolic process
|
GO:0010675 |
47 |
0.038
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.038
|
Human |
|
|
negative regulation of type i interferon mediated signaling pathway
|
GO:0060339 |
4 |
0.038
|
|
|
|
stem cell development
|
GO:0048864 |
69 |
0.038
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.038
|
|
|
|
negative regulation of vascular endothelial growth factor receptor signaling pathway
|
GO:0030948 |
3 |
0.037
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.037
|
|
|
|
receptor internalization involved in canonical wnt signaling pathway
|
GO:2000286 |
3 |
0.036
|
|
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
46 |
0.036
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.036
|
|
|
|
striated muscle contraction
|
GO:0006941 |
52 |
0.036
|
|
|
|
positive regulation of dendrite morphogenesis
|
GO:0050775 |
3 |
0.035
|
|
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.035
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.035
|
Fly |
|
|
response to fibroblast growth factor
|
GO:0071774 |
39 |
0.035
|
Fly |
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.035
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.035
|
Human |
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.034
|
Mouse |
|
|
single organism behavior
|
GO:0044708 |
28 |
0.034
|
|
|
|
response to testosterone
|
GO:0033574 |
1 |
0.034
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.034
|
|
|
|
regulation of b cell receptor signaling pathway
|
GO:0050855 |
4 |
0.034
|
|
|
|
negative regulation of t cell receptor signaling pathway
|
GO:0050860 |
4 |
0.034
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.033
|
Human |
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.033
|
|
|
|
membrane depolarization
|
GO:0051899 |
26 |
0.033
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.033
|
Mouse |
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.033
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.033
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.033
|
Zebrafish Fly |
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.032
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.032
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.032
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.032
|
|
|
|
regulation of carbohydrate metabolic process
|
GO:0006109 |
54 |
0.032
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.032
|
|
|
|
endoplasmic reticulum organization
|
GO:0007029 |
20 |
0.032
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.032
|
|
|
|
semaphorin plexin signaling pathway
|
GO:0071526 |
4 |
0.031
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.031
|
|
|
|
striated muscle cell development
|
GO:0055002 |
27 |
0.031
|
|
|
|
negative regulation of hydrogen peroxide mediated programmed cell death
|
GO:1901299 |
3 |
0.031
|
|
|
|
leukocyte chemotaxis
|
GO:0030595 |
76 |
0.031
|
|
|
|
positive regulation of cellular response to insulin stimulus
|
GO:1900078 |
6 |
0.031
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.031
|
|
|
|
multi organism reproductive process
|
GO:0044703 |
54 |
0.031
|
Fly |
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.031
|
|
|
|
regulation of epidermal growth factor receptor signaling pathway
|
GO:0042058 |
27 |
0.031
|
|
|
|
regulation of multicellular organism growth
|
GO:0040014 |
8 |
0.031
|
Mouse |
|
|
protein processing
|
GO:0016485 |
226 |
0.030
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.030
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.030
|
Mouse |
