|
|
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway
|
GO:0035625 |
4 |
0.603
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.586
|
Human |
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.419
|
|
|
|
regulation of excitatory postsynaptic membrane potential
|
GO:0060079 |
1 |
0.396
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.294
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.263
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.222
|
Human |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.196
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.189
|
|
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.174
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.174
|
Human |
|
|
positive regulation of vasodilation
|
GO:0045909 |
4 |
0.173
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.167
|
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.166
|
Human Rat Fly |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.165
|
|
|
|
phospholipase c activating adrenergic receptor signaling pathway
|
GO:0071882 |
1 |
0.162
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.161
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.157
|
Human Zebrafish |
|
|
cation transport
|
GO:0006812 |
331 |
0.156
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.155
|
|
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.153
|
|
|
|
positive regulation of leukocyte chemotaxis
|
GO:0002690 |
38 |
0.146
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.131
|
|
|
|
regulation of bone mineralization
|
GO:0030500 |
29 |
0.130
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.127
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.125
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.117
|
Human Zebrafish |
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.114
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.113
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.109
|
Human |
|
|
activation of mapk activity by adrenergic receptor signaling pathway
|
GO:0071883 |
3 |
0.109
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.107
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.106
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.104
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.104
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.103
|
|
|
|
negative regulation of insulin secretion involved in cellular response to glucose stimulus
|
GO:0061179 |
1 |
0.101
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.099
|
Human |
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.098
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.097
|
|
|
|
receptor transactivation
|
GO:0035624 |
4 |
0.096
|
|
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
0.096
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.096
|
Human |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.092
|
|
|
|
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000058 |
7 |
0.091
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.091
|
Human Zebrafish |
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.089
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.088
|
Human |
|
|
regulation of leukocyte migration
|
GO:0002685 |
63 |
0.087
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.086
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.084
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.084
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.083
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.082
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.082
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.081
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.081
|
Mouse |
|
|
positive regulation of chemotaxis
|
GO:0050921 |
57 |
0.081
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.081
|
Mouse |
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.080
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.080
|
Human |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.078
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.078
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.078
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.078
|
|
|
|
regulation of cgmp mediated signaling
|
GO:0010752 |
1 |
0.077
|
|
|
|
regulation of erbb signaling pathway
|
GO:1901184 |
27 |
0.077
|
|
|
|
regulation of postsynaptic membrane potential
|
GO:0060078 |
1 |
0.076
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.076
|
|
|
|
regulation of potassium ion transport
|
GO:0043266 |
24 |
0.076
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.075
|
Human |
|
|
regulation of macrophage chemotaxis
|
GO:0010758 |
4 |
0.074
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.073
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.073
|
Human |
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.073
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.072
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.071
|
|
|
|
vasodilation
|
GO:0042311 |
4 |
0.071
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.069
|
Human |
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.069
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.069
|
Zebrafish |
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.069
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.067
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.067
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.066
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.066
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
84 |
0.065
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.062
|
|
|
|
regulation of vasodilation
|
GO:0042312 |
4 |
0.062
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.061
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.061
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.061
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.061
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.060
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.060
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.060
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.060
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.059
|
|
|
|
positive regulation of behavior
|
GO:0048520 |
60 |
0.059
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.058
|
Human |
|
|
regulation of behavior
|
GO:0050795 |
82 |
0.058
|
|
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
4 |
0.057
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.057
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.057
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.055
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.055
|
Human |
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.055
|
|
|
|
regulation of lymphocyte chemotaxis
|
GO:1901623 |
12 |
0.055
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.054
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.052
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.052
|
Human |
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
31 |
0.052
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.052
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.052
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.051
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.051
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.051
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.051
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.051
|
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.051
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.050
|
|
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
61 |
0.050
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.050
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.050
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.049
|
|
|
|
positive regulation of epidermal growth factor receptor signaling pathway
|
GO:0045742 |
11 |
0.049
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.049
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.048
|
|
|
|
adenylate cyclase inhibiting serotonin receptor signaling pathway
|
GO:0007198 |
2 |
0.047
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.047
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.046
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.046
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.046
|
Mouse |
|
|
regulation of chemotaxis
|
GO:0050920 |
74 |
0.046
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.045
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.045
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.045
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.045
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.045
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.045
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.044
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.044
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.044
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.044
|
Mouse |
|
|
positive regulation of lymphocyte migration
|
GO:2000403 |
16 |
0.044
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
44 |
0.044
|
|
|
|
membrane protein proteolysis
|
GO:0033619 |
38 |
0.043
|
|
|
|
regulation of biomineral tissue development
|
GO:0070167 |
31 |
0.043
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.043
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.042
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.042
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.042
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.041
|
|
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
49 |
0.040
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.040
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.040
|
|
|
|
regulation of growth rate
|
GO:0040009 |
1 |
0.040
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.040
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.040
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.040
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.040
|
Human |
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.039
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.039
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.039
|
|
|
|
positive regulation of protein kinase b signaling
|
GO:0051897 |
42 |
0.039
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.039
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.039
|
|
|
|
behavioral response to ethanol
|
GO:0048149 |
2 |
0.038
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.038
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.038
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.038
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.038
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.038
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.038
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.037
|
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.037
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.037
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.037
|
Human |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.036
|
Human |
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.036
|
Human |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.036
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.036
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.036
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.035
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.035
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.035
|
|
|
|
positive regulation of protein polymerization
|
GO:0032273 |
45 |
0.035
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.035
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.035
|
Rat Fly |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.035
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
59 |
0.034
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.034
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.034
|
Human |
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.034
|
Human |
|
|
erbb signaling pathway
|
GO:0038127 |
44 |
0.034
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.034
|
|
|
|
cardiac muscle adaptation
|
GO:0014887 |
4 |
0.034
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.034
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.033
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.033
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.033
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.033
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.033
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.033
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.033
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.032
|
|
|
|
adenylate cyclase inhibiting adrenergic receptor signaling pathway
|
GO:0071881 |
1 |
0.032
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.032
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.032
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.032
|
|
|
|
regulation of cell adhesion mediated by integrin
|
GO:0033628 |
22 |
0.032
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.031
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.031
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.031
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.031
|
|
|
|
desensitization of g protein coupled receptor protein signaling pathway by arrestin
|
GO:0002032 |
2 |
0.031
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.031
|
Human |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.031
|
Human |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.031
|
|
|
|
positive regulation of oxidoreductase activity
|
GO:0051353 |
26 |
0.031
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.031
|
|
|
|
intestine smooth muscle contraction
|
GO:0014827 |
2 |
0.031
|
|
|
|
bone mineralization
|
GO:0030282 |
34 |
0.031
|
|
|
|
cilium morphogenesis
|
GO:0060271 |
75 |
0.030
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.030
|
|
|
|
regulation of leukocyte chemotaxis
|
GO:0002688 |
46 |
0.030
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.030
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.030
|
|
|
|
response to camp
|
GO:0051591 |
25 |
0.030
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.030
|
|
|
|
rap protein signal transduction
|
GO:0032486 |
7 |
0.030
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.030
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.029
|
|
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.029
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.029
|
|
|
|
long term synaptic potentiation
|
GO:0060291 |
1 |
0.029
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.029
|
|
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.029
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.029
|
|
|
|
leukocyte chemotaxis
|
GO:0030595 |
76 |
0.029
|
|
|
|
negative regulation of cell cell adhesion
|
GO:0022408 |
27 |
0.029
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.029
|
|
|
|
coagulation
|
GO:0050817 |
78 |
0.029
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.029
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.029
|
|
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.028
|
|
|
|
positive regulation of protein tyrosine kinase activity
|
GO:0061098 |
24 |
0.028
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.028
|
|
|
|
negative regulation of cell substrate adhesion
|
GO:0010812 |
24 |
0.028
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.028
|
Human |
|
|
response to other organism
|
GO:0051707 |
261 |
0.028
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.028
|
|
|
|
neurotrophin signaling pathway
|
GO:0038179 |
8 |
0.028
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.028
|
|
|
|
neurotrophin trk receptor signaling pathway
|
GO:0048011 |
4 |
0.028
|
|
|
|
regulation of lymphocyte migration
|
GO:2000401 |
22 |
0.027
|
|
|
|
adult locomotory behavior
|
GO:0008344 |
1 |
0.027
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.027
|
|
|
|
epithelial cell development
|
GO:0002064 |
34 |
0.027
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.027
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.027
|
Mouse |
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.027
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.026
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.026
|
|
|
|
regulation of nucleotide biosynthetic process
|
GO:0030808 |
50 |
0.026
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.026
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.026
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.026
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.026
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.026
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.026
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.026
|
Rat Fly |
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.025
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.025
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.025
|
|
|
|
semaphorin plexin signaling pathway
|
GO:0071526 |
4 |
0.025
|
|
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.025
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.025
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.025
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.025
|
|
|
|
growth
|
GO:0040007 |
202 |
0.025
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.025
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.025
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.025
|
Human |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.025
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.025
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.025
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.024
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.024
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.024
|
Human |
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.024
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.024
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.024
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.024
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.024
|
|
|
|
activation of janus kinase activity
|
GO:0042976 |
7 |
0.024
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.024
|
Mouse |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.024
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.024
|
|
|
|
membrane protein ectodomain proteolysis
|
GO:0006509 |
33 |
0.023
|
|
|
|
epidermal growth factor receptor signaling pathway
|
GO:0007173 |
39 |
0.023
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.023
|
|
|
|
positive regulation of monooxygenase activity
|
GO:0032770 |
14 |
0.023
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.023
|
|
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.023
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.023
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.023
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.023
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.022
|
|
|
|
tissue homeostasis
|
GO:0001894 |
63 |
0.022
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.022
|
|
|
|
positive regulation of phosphatidylinositol biosynthetic process
|
GO:0010513 |
3 |
0.022
|
|
|
|
regulation of cell substrate adhesion
|
GO:0010810 |
68 |
0.022
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.022
|
|
|
|
sensory perception of sound
|
GO:0007605 |
37 |
0.022
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.022
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.022
|
|
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.022
|
|
|
|
negative regulation of platelet aggregation
|
GO:0090331 |
3 |
0.021
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.021
|
|
|
|
response to organophosphorus
|
GO:0046683 |
41 |
0.021
|
|
|
|
short term memory
|
GO:0007614 |
1 |
0.021
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.021
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.021
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.021
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.021
|
|
|
|
response to hydrogen peroxide
|
GO:0042542 |
40 |
0.021
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.021
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.021
|
Fly |
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.021
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.021
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.021
|
Zebrafish |
|
|
taxis
|
GO:0042330 |
157 |
0.021
|
Fly |
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.021
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.021
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.021
|
|
|
|
regulation of inositol phosphate biosynthetic process
|
GO:0010919 |
3 |
0.021
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.021
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.020
|
|
|
|
lymphocyte migration
|
GO:0072676 |
28 |
0.020
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.020
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.020
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.020
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.020
|
|
|
|
response to lithium ion
|
GO:0010226 |
2 |
0.020
|
|
|
|
regulation of body fluid levels
|
GO:0050878 |
99 |
0.020
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.020
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.020
|
|
|
|
regulation of blood coagulation
|
GO:0030193 |
42 |
0.020
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.020
|
Human Rat Fly |
|
|
epithelial tube branching involved in lung morphogenesis
|
GO:0060441 |
4 |
0.019
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
67 |
0.019
|
|
|
|
keratinization
|
GO:0031424 |
2 |
0.019
|
|
|
|
platelet derived growth factor receptor beta signaling pathway
|
GO:0035791 |
4 |
0.019
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.019
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.019
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.019
|
|
|
|
positive regulation of cell substrate adhesion
|
GO:0010811 |
37 |
0.019
|
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.019
|
|
|
|
regulation of clathrin mediated endocytosis
|
GO:2000369 |
4 |
0.019
|
|
|
|
salivary gland morphogenesis
|
GO:0007435 |
4 |
0.019
|
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.019
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.019
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.019
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.019
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.019
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.019
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.019
|
|
|
|
negative regulation of sequestering of calcium ion
|
GO:0051283 |
41 |
0.018
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.018
|
Fly |
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.018
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.018
|
|
|
|
positive regulation of leukocyte migration
|
GO:0002687 |
46 |
0.018
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.018
|
|
|
|
protein kinase c signaling
|
GO:0070528 |
17 |
0.018
|
|
|
|
response to estradiol
|
GO:0032355 |
23 |
0.018
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.018
|
Fly |
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.018
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.018
|
|
|
|
peptidyl tyrosine dephosphorylation
|
GO:0035335 |
36 |
0.018
|
Human Rat Fly |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.018
|
|
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.018
|
|
|
|
memory
|
GO:0007613 |
3 |
0.018
|
|
|
|
negative regulation of homotypic cell cell adhesion
|
GO:0034111 |
3 |
0.018
|
|
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
41 |
0.018
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.018
|
|
|
|
positive regulation of cell matrix adhesion
|
GO:0001954 |
23 |
0.018
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.018
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
36 |
0.018
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.018
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.018
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.018
|
|
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.018
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.018
|
|
|
|
positive regulation of actin filament polymerization
|
GO:0030838 |
38 |
0.017
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.017
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.017
|
Mouse |
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.017
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.017
|
|
|
|
regulation of natural killer cell differentiation
|
GO:0032823 |
2 |
0.017
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.017
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.017
|
|
|
|
positive regulation of cell growth
|
GO:0030307 |
48 |
0.017
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.017
|
|
|
|
negative regulation of blood pressure
|
GO:0045776 |
3 |
0.017
|
|
|
|
tissue remodeling
|
GO:0048771 |
16 |
0.017
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.017
|
|
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.017
|
|
|
|
regulation of release of sequestered calcium ion into cytosol
|
GO:0051279 |
27 |
0.017
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.016
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.016
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.016
|
|
|
|
response to decreased oxygen levels
|
GO:0036293 |
96 |
0.016
|
|
|
|
ossification
|
GO:0001503 |
121 |
0.016
|
|
|
|
positive regulation of erbb signaling pathway
|
GO:1901186 |
11 |
0.016
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.016
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.016
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.016
|
Fly |
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.016
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.016
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.016
|
|
|
|
regulation of cell matrix adhesion
|
GO:0001952 |
42 |
0.016
|
|
|
|
lung growth
|
GO:0060437 |
2 |
0.016
|
|
|
|
response to fungus
|
GO:0009620 |
4 |
0.016
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.016
|
|
|
|
regulation of rap protein signal transduction
|
GO:0032487 |
9 |
0.016
|
|
|
|
regulation of epidermal growth factor receptor signaling pathway
|
GO:0042058 |
27 |
0.016
|
|
|
|
negative regulation of hemostasis
|
GO:1900047 |
22 |
0.016
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.016
|
Zebrafish |
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.016
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.016
|
Rat |
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.016
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.016
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.016
|
|
|
|
cellular response to acid chemical
|
GO:0071229 |
44 |
0.016
|
|
|
|
positive regulation of camp biosynthetic process
|
GO:0030819 |
35 |
0.016
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.015
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.015
|
|
|
|
regulation of receptor activity
|
GO:0010469 |
47 |
0.015
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.015
|
Mouse |
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
55 |
0.015
|
|
|
|
actin filament polymerization
|
GO:0030041 |
45 |
0.015
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.015
|
|
|
|
cellular defense response
|
GO:0006968 |
2 |
0.015
|
|
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.015
|
|
|
|
regulation of g protein coupled receptor protein signaling pathway
|
GO:0008277 |
35 |
0.015
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.015
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.015
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.015
|
|
|
|
female genitalia development
|
GO:0030540 |
2 |
0.015
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.015
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.015
|
|
|
|
trivalent inorganic cation transport
|
GO:0072512 |
4 |
0.015
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.015
|
|
|
|
atp metabolic process
|
GO:0046034 |
176 |
0.015
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.015
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.015
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.015
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.015
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.015
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.015
|
Rat |
|
|
negative regulation of muscle contraction
|
GO:0045932 |
3 |
0.015
|
|
|
|
positive regulation of rap gtpase activity
|
GO:0032854 |
8 |
0.015
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.015
|
|
|
|
regulation of monooxygenase activity
|
GO:0032768 |
22 |
0.015
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.015
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.015
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.015
|
Human |
|
|
regulation of short term neuronal synaptic plasticity
|
GO:0048172 |
1 |
0.015
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.015
|
|
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
38 |
0.014
|
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.014
|
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.014
|
|
|
|
sensory perception of mechanical stimulus
|
GO:0050954 |
37 |
0.014
|
|
|
|
prostate gland development
|
GO:0030850 |
3 |
0.014
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.014
|
|
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.014
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.014
|
|
|
|
regulation of t cell chemotaxis
|
GO:0010819 |
7 |
0.014
|
|