Homo sapiens

0 known processes

PUM2

pumilio homolog 2 (Drosophila)

(Aliases: PUML2,KIAA0235,FLJ36528,MGC138253,MGC138251,PUMH2)

PUM2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of gene silencing by mirna GO:0060965 3 0.989
negative regulation of posttranscriptional gene silencing GO:0060149 3 0.768
small gtpase mediated signal transduction GO:0007264 78 0.668
regulation of cellular component biogenesis GO:0044087 281 0.661
Fly
negative regulation of gene silencing by rna GO:0060967 3 0.518
post embryonic development GO:0009791 2 0.512
Worm
female gamete generation GO:0007292 2 0.491
cell division GO:0051301 168 0.484
Worm
locomotory behavior GO:0007626 1 0.420
enzyme linked receptor protein signaling pathway GO:0007167 303 0.387
Fly
oocyte differentiation GO:0009994 2 0.363
chromatin modification GO:0016568 298 0.355
neural tube patterning GO:0021532 2 0.331
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.273
Fly
macromolecule methylation GO:0043414 97 0.259
ras protein signal transduction GO:0007265 73 0.256
mitotic cell cycle GO:0000278 326 0.254
cellular macromolecular complex assembly GO:0034622 324 0.253
Mouse
neuron differentiation GO:0030182 138 0.250
Fly
organelle fission GO:0048285 149 0.247
Worm
regulation of cell cycle process GO:0010564 266 0.232
Worm
embryonic placenta development GO:0001892 1 0.225
oogenesis GO:0048477 2 0.221
dendrite development GO:0016358 24 0.220
Fly
generation of neurons GO:0048699 152 0.210
Fly
translation GO:0006412 132 0.204
determination of adult lifespan GO:0008340 2 0.198
organelle assembly GO:0070925 176 0.196
Mouse
embryo development GO:0009790 123 0.190
Fly
nucleoside triphosphate metabolic process GO:0009141 422 0.190
circulatory system development GO:0072359 262 0.187
organophosphate catabolic process GO:0046434 430 0.184
cellular component morphogenesis GO:0032989 314 0.180
Fly
chromosome segregation GO:0007059 114 0.175
purine nucleoside triphosphate metabolic process GO:0009144 412 0.173
nuclear division GO:0000280 128 0.172
Worm
regulation of cell cycle GO:0051726 393 0.168
Worm
positive regulation of cellular component organization GO:0051130 376 0.160
purine ribonucleotide catabolic process GO:0009154 404 0.154
regulation of chromatin modification GO:1903308 51 0.151
regulation of synaptic transmission GO:0050804 11 0.151
Fly
positive regulation of organelle organization GO:0010638 195 0.149
anatomical structure formation involved in morphogenesis GO:0048646 284 0.148
system process GO:0003008 349 0.147
Fly
cardiovascular system development GO:0072358 262 0.147
posttranscriptional gene silencing by rna GO:0035194 25 0.144
positive regulation of axonogenesis GO:0050772 9 0.144
nucleoside triphosphate catabolic process GO:0009143 394 0.142
regulation of cellular amino acid metabolic process GO:0006521 6 0.141
regulation of growth GO:0040008 165 0.138
Fly
ribonucleoprotein complex biogenesis GO:0022613 116 0.138
Mouse
regulation of cellular amine metabolic process GO:0033238 11 0.132
neurological system process GO:0050877 163 0.131
Fly
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.128
cellular amine metabolic process GO:0044106 41 0.124
vesicle mediated transport GO:0016192 371 0.122
cellular ketone metabolic process GO:0042180 80 0.122
regulation of small gtpase mediated signal transduction GO:0051056 156 0.119
cellular amino acid metabolic process GO:0006520 116 0.119
nucleoside catabolic process GO:0009164 408 0.118
ribonucleoside triphosphate metabolic process GO:0009199 412 0.107
regulation of chromatin organization GO:1902275 56 0.105
ribonucleotide catabolic process GO:0009261 405 0.104
neuron projection development GO:0031175 106 0.103
Fly
purine nucleotide catabolic process GO:0006195 405 0.101
cellular carbohydrate metabolic process GO:0044262 84 0.099
negative regulation of synaptic transmission GO:0050805 2 0.098
oocyte development GO:0048599 1 0.096
long term memory GO:0007616 2 0.095
Fly
purine ribonucleoside catabolic process GO:0046130 398 0.094
regulation of gene silencing GO:0060968 24 0.092
cell projection organization GO:0030030 252 0.090
Fly
cytokinesis GO:0000910 96 0.090
growth GO:0040007 202 0.089
Fly
multicellular organismal aging GO:0010259 3 0.089
neuron development GO:0048666 113 0.087
Fly
response to biotic stimulus GO:0009607 276 0.086
mitotic cell cycle process GO:1903047 286 0.086
protein polymerization GO:0051258 71 0.085
regulation of ras protein signal transduction GO:0046578 155 0.083
regulation of developmental growth GO:0048638 30 0.082
Fly
cell part morphogenesis GO:0032990 137 0.081
Fly
regulation of cell development GO:0060284 161 0.081
cell projection morphogenesis GO:0048858 129 0.081
Fly
nervous system development GO:0007399 293 0.081
Fly
behavioral response to ethanol GO:0048149 2 0.078
Fly
purine nucleoside triphosphate catabolic process GO:0009146 392 0.077
dephosphorylation GO:0016311 209 0.077
regulation of cell morphogenesis GO:0022604 153 0.077
amine metabolic process GO:0009308 44 0.075
nucleotide catabolic process GO:0009166 408 0.074
positive regulation of cellular amine metabolic process GO:0033240 7 0.074
memory GO:0007613 3 0.073
Fly
nucleoside phosphate catabolic process GO:1901292 412 0.072
blood vessel morphogenesis GO:0048514 162 0.072
cell cell signaling GO:0007267 155 0.072
Fly
purine containing compound catabolic process GO:0072523 411 0.071
regulation of anatomical structure morphogenesis GO:0022603 286 0.071
regulation of mitotic cell cycle GO:0007346 189 0.070
response to radiation GO:0009314 151 0.070
regulation of nucleotide metabolic process GO:0006140 269 0.069
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.067
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.066
rna processing GO:0006396 255 0.065
ribonucleoside catabolic process GO:0042454 406 0.065
cell morphogenesis GO:0000902 296 0.064
Fly
ribonucleoside triphosphate catabolic process GO:0009203 391 0.063
regulation of translation GO:0006417 89 0.063
regulation of dna metabolic process GO:0051052 153 0.063
blastocyst formation GO:0001825 3 0.062
circadian sleep wake cycle sleep GO:0050802 2 0.062
negative regulation of phosphate metabolic process GO:0045936 267 0.062
Worm
vasculature development GO:0001944 181 0.061
purine nucleoside catabolic process GO:0006152 398 0.061
behavior GO:0007610 112 0.061
Fly
mrna metabolic process GO:0016071 175 0.060
cellular protein complex assembly GO:0043623 188 0.060
microtubule based process GO:0007017 210 0.059
axon development GO:0061564 34 0.059
neuroblast proliferation GO:0007405 4 0.059
developmental growth GO:0048589 48 0.059
Fly
histone lysine methylation GO:0034968 50 0.058
negative regulation of cellular component organization GO:0051129 235 0.058
regulation of nucleotide catabolic process GO:0030811 205 0.058
positive regulation of developmental process GO:0051094 314 0.058
neural tube formation GO:0001841 3 0.057
embryo development ending in birth or egg hatching GO:0009792 34 0.057
Fly
cell morphogenesis involved in differentiation GO:0000904 144 0.056
Fly
regulation of histone modification GO:0031056 47 0.055
positive regulation of phosphorylation GO:0042327 394 0.054
gene silencing GO:0016458 49 0.054
covalent chromatin modification GO:0016569 254 0.052
cellular response to oxygen containing compound GO:1901701 276 0.052
response to other organism GO:0051707 261 0.051
reproductive process GO:0022414 106 0.050
Worm Fly
purine ribonucleoside metabolic process GO:0046128 437 0.049
developmental maturation GO:0021700 28 0.049
centrosome organization GO:0051297 58 0.048
regulation of multi organism process GO:0043900 157 0.048
embryonic morphogenesis GO:0048598 85 0.048
Fly
ameboidal type cell migration GO:0001667 135 0.048
glycosyl compound catabolic process GO:1901658 413 0.047
negative regulation of neuron apoptotic process GO:0043524 23 0.047
single organism cellular localization GO:1902580 332 0.046
cell development GO:0048468 328 0.045
Fly
regulation of meiosis GO:0040020 3 0.043
Worm
cell cycle phase transition GO:0044770 173 0.043
cellular response to organonitrogen compound GO:0071417 124 0.043
short term memory GO:0007614 1 0.043
embryonic epithelial tube formation GO:0001838 4 0.043
positive regulation of chromatin modification GO:1903310 30 0.042
regulation of cell differentiation GO:0045595 393 0.042
regulation of protein complex assembly GO:0043254 147 0.042
regulation of cell projection organization GO:0031344 107 0.042
regulation of microtubule cytoskeleton organization GO:0070507 61 0.042
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.041
immune response GO:0006955 307 0.041
carbohydrate metabolic process GO:0005975 207 0.041
neurogenesis GO:0022008 169 0.040
Fly
posttranscriptional regulation of gene expression GO:0010608 213 0.040
positive regulation of cell development GO:0010720 92 0.040
negative regulation of cell cycle GO:0045786 193 0.039
ribonucleoprotein complex subunit organization GO:0071826 81 0.039
Mouse
cellular response to endogenous stimulus GO:0071495 336 0.038
spermatid differentiation GO:0048515 4 0.038
chemotaxis GO:0006935 157 0.038
positive regulation of nucleotide catabolic process GO:0030813 185 0.038
mitotic cell cycle phase transition GO:0044772 162 0.037
neuromuscular junction development GO:0007528 3 0.037
Fly
positive regulation of purine nucleotide biosynthetic process GO:1900373 38 0.037
negative regulation of mitotic cell cycle GO:0045930 102 0.037
cellular component assembly involved in morphogenesis GO:0010927 73 0.037
morphogenesis of embryonic epithelium GO:0016331 4 0.037
rhythmic behavior GO:0007622 2 0.036
sleep GO:0030431 2 0.036
organelle localization GO:0051640 84 0.035
negative regulation of apoptotic process GO:0043066 316 0.035
negative regulation of phosphorus metabolic process GO:0010563 267 0.035
Worm
regulation of gtpase activity GO:0043087 180 0.035
heart development GO:0007507 95 0.034
response to growth factor GO:0070848 205 0.034
rna catabolic process GO:0006401 71 0.033
cellular response to peptide hormone stimulus GO:0071375 56 0.033
engulfment of apoptotic cell GO:0043652 2 0.033
neural tube closure GO:0001843 3 0.033
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.032
protein targeting GO:0006605 187 0.032
regulation of protein kinase activity GO:0045859 289 0.032
positive regulation of leukocyte activation GO:0002696 80 0.031
response to external biotic stimulus GO:0043207 261 0.031
positive regulation of neuron differentiation GO:0045666 40 0.031
cellular macromolecule catabolic process GO:0044265 380 0.031
regulation of cellular component size GO:0032535 82 0.030
mrna stabilization GO:0048255 18 0.030
regulation of cyclic nucleotide metabolic process GO:0030799 63 0.030
positive regulation of catabolic process GO:0009896 310 0.030
chordate embryonic development GO:0043009 34 0.030
cellular homeostasis GO:0019725 196 0.029
positive regulation of cellular catabolic process GO:0031331 284 0.029
regulation of gene expression epigenetic GO:0040029 73 0.029
methylation GO:0032259 106 0.029
mrna splicing via spliceosome GO:0000398 89 0.029
blood vessel development GO:0001568 172 0.028
meiotic nuclear division GO:0007126 10 0.028
Worm
aging GO:0007568 66 0.028
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.028
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.028
actin cytoskeleton organization GO:0030036 207 0.027
membrane organization GO:0061024 292 0.027
response to organonitrogen compound GO:0010243 156 0.027
segmentation GO:0035282 4 0.026
negative regulation of cell death GO:0060548 345 0.026
negative regulation of catalytic activity GO:0043086 335 0.026
single organism carbohydrate metabolic process GO:0044723 193 0.026
positive regulation of neurogenesis GO:0050769 49 0.026
regulation of anatomical structure size GO:0090066 101 0.025
negative regulation of cellular protein metabolic process GO:0032269 353 0.025
ribonucleotide biosynthetic process GO:0009260 81 0.025
spermatid development GO:0007286 4 0.025
cell type specific apoptotic process GO:0097285 125 0.025
regulation of chromosome organization GO:0033044 103 0.024
regulation of protein localization GO:0032880 296 0.024
positive regulation of nervous system development GO:0051962 54 0.024
gtp catabolic process GO:0006184 237 0.024
regulation of cyclic nucleotide biosynthetic process GO:0030802 49 0.024
regulation of carbohydrate metabolic process GO:0006109 54 0.023
chromatin organization GO:0006325 351 0.023
endocytosis GO:0006897 159 0.023
positive regulation of nucleotide metabolic process GO:0045981 230 0.023
chemical homeostasis GO:0048878 306 0.023
regionalization GO:0003002 29 0.022
cognition GO:0050890 43 0.022
Fly
response to hormone GO:0009725 175 0.022
regulation of nucleotide biosynthetic process GO:0030808 50 0.022
microtubule cytoskeleton organization GO:0000226 176 0.022
positive regulation of ras gtpase activity GO:0032320 117 0.022
regulation of cellular ketone metabolic process GO:0010565 50 0.022
microtubule organizing center organization GO:0031023 62 0.022
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.022
multicellular organism reproduction GO:0032504 42 0.022
Worm Fly
regulation of cytoskeleton organization GO:0051493 177 0.021
peptidyl serine modification GO:0018209 106 0.021
negative regulation of hydrolase activity GO:0051346 182 0.021
regulation of dna replication GO:0006275 68 0.021
ubiquitin dependent protein catabolic process GO:0006511 206 0.020
organ morphogenesis GO:0009887 147 0.020
endothelial cell migration GO:0043542 86 0.020
axonogenesis GO:0007409 31 0.020
negative regulation of cell cycle phase transition GO:1901988 89 0.020
tissue migration GO:0090130 119 0.020
regulation of protein targeting GO:1903533 91 0.020
response to oxygen containing compound GO:1901700 369 0.020
Fly
negative regulation of programmed cell death GO:0043069 321 0.020
apoptotic signaling pathway GO:0097190 268 0.020
protein deacetylation GO:0006476 38 0.019
regulation of neuron projection development GO:0010975 57 0.019
histone modification GO:0016570 251 0.019
cellular response to hormone stimulus GO:0032870 125 0.019
meiosis i GO:0007127 4 0.019
nucleoside monophosphate metabolic process GO:0009123 191 0.019
regulation of phosphatase activity GO:0010921 81 0.018
jnk cascade GO:0007254 80 0.018
protein acylation GO:0043543 138 0.018
cellular response to dna damage stimulus GO:0006974 379 0.018
anterior posterior axis specification GO:0009948 2 0.018
nucleotide biosynthetic process GO:0009165 109 0.018
actin filament based process GO:0030029 224 0.018
positive regulation of protein phosphorylation GO:0001934 313 0.018
purine nucleotide biosynthetic process GO:0006164 84 0.018
neuron projection morphogenesis GO:0048812 50 0.018
Fly
regulation of mitotic spindle checkpoint GO:1903504 8 0.018
angiogenesis GO:0001525 147 0.018
transmembrane transport GO:0055085 399 0.018
regulation of response to dna damage stimulus GO:2001020 94 0.018
negative regulation of protein metabolic process GO:0051248 391 0.018
double strand break repair GO:0006302 101 0.017
mitotic nuclear division GO:0007067 119 0.017
intracellular mrna localization GO:0008298 1 0.017
ribosome assembly GO:0042255 9 0.017
rho protein signal transduction GO:0007266 26 0.017
protein localization to nucleus GO:0034504 136 0.017
regulation of nervous system development GO:0051960 88 0.017
Fly
multicellular organismal reproductive process GO:0048609 40 0.017
Worm Fly
response to carbohydrate GO:0009743 21 0.017
epithelium migration GO:0090132 119 0.017
tube development GO:0035295 125 0.017
circadian behavior GO:0048512 2 0.017
positive regulation of histone modification GO:0031058 29 0.016
maintenance of location GO:0051235 112 0.016
regulation of protein transport GO:0051223 213 0.016
mating GO:0007618 1 0.016
mitotic spindle organization GO:0007052 27 0.016
regulation of rho protein signal transduction GO:0035023 79 0.016
epithelial cell migration GO:0010631 119 0.016
hindbrain development GO:0030902 3 0.016
regulation of ras gtpase activity GO:0032318 128 0.016
response to insulin GO:0032868 45 0.016
cellular response to nitrogen compound GO:1901699 144 0.016
positive regulation of protein kinase activity GO:0045860 190 0.016
protein deacylation GO:0035601 39 0.016
negative regulation of cell cycle process GO:0010948 121 0.016
negative regulation of growth GO:0045926 97 0.016
mapk cascade GO:0000165 288 0.016
Worm
nucleus localization GO:0051647 1 0.016
male meiosis GO:0007140 1 0.015
Worm
axon extension GO:0048675 13 0.015
regulation of intracellular transport GO:0032386 195 0.015
purine nucleoside monophosphate catabolic process GO:0009128 158 0.015
cellular response to external stimulus GO:0071496 111 0.015
intracellular protein transport GO:0006886 270 0.015
purine nucleoside monophosphate metabolic process GO:0009126 186 0.015
skeletal system development GO:0001501 79 0.015
protein acetylation GO:0006473 116 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
protein dephosphorylation GO:0006470 81 0.015
positive regulation of cell differentiation GO:0045597 211 0.015
regulation of mitotic cell cycle phase transition GO:1901990 118 0.015
embryonic skeletal system development GO:0048706 13 0.015
nucleoside monophosphate catabolic process GO:0009125 159 0.015
regulation of cellular response to stress GO:0080135 244 0.015
positive regulation of gtpase activity GO:0043547 166 0.015
regulation of microtubule based process GO:0032886 74 0.015
single organism reproductive process GO:0044702 98 0.015
Worm Fly
developmental process involved in reproduction GO:0003006 66 0.015
Worm
cellular response to insulin stimulus GO:0032869 41 0.014
negative regulation of nervous system development GO:0051961 28 0.014
dna integrity checkpoint GO:0031570 71 0.014
regulation of protein glycosylation GO:0060049 6 0.014
protein ubiquitination GO:0016567 314 0.014
signal transduction by phosphorylation GO:0023014 297 0.014
Worm
gene silencing by rna GO:0031047 26 0.014
dna repair GO:0006281 198 0.014
response to peptide hormone GO:0043434 61 0.014
regulation of purine nucleotide metabolic process GO:1900542 264 0.014
establishment of protein localization to organelle GO:0072594 172 0.014
cytoplasmic transport GO:0016482 379 0.014
tube closure GO:0060606 3 0.014
mitotic cell cycle checkpoint GO:0007093 68 0.014
negative regulation of cell differentiation GO:0045596 171 0.014
secretion GO:0046903 254 0.013
insulin receptor signaling pathway GO:0008286 23 0.013
humoral immune response GO:0006959 49 0.013
regulation of meiotic cell cycle GO:0051445 4 0.013
Worm
regulation of response to external stimulus GO:0032101 222 0.013
regulation of organelle assembly GO:1902115 40 0.013
associative learning GO:0008306 1 0.013
circadian sleep wake cycle process GO:0022410 2 0.013
stem cell differentiation GO:0048863 93 0.013
regulation of reactive oxygen species metabolic process GO:2000377 41 0.013
multi organism cellular process GO:0044764 156 0.013
lymphocyte activation GO:0046649 133 0.013
reproduction GO:0000003 63 0.013
Worm Fly
negative regulation of phosphatase activity GO:0010923 61 0.013
head development GO:0060322 108 0.013
mitotic spindle elongation GO:0000022 4 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
regulation of immune effector process GO:0002697 91 0.013
response to nitrogen compound GO:1901698 184 0.013
stem cell development GO:0048864 69 0.013
primary neural tube formation GO:0014020 3 0.013
protein complex disassembly GO:0043241 52 0.012
adult locomotory behavior GO:0008344 1 0.012
regulation of rna stability GO:0043487 23 0.012
ribonucleoside monophosphate catabolic process GO:0009158 158 0.012
positive regulation of dna metabolic process GO:0051054 73 0.012
protein catabolic process GO:0030163 325 0.012
guanosine containing compound catabolic process GO:1901069 239 0.012
internal protein amino acid acetylation GO:0006475 101 0.012
rna splicing GO:0008380 131 0.012
viral process GO:0016032 146 0.012
internal peptidyl lysine acetylation GO:0018393 97 0.012
reproductive structure development GO:0048608 55 0.012
regulation of neuron death GO:1901214 56 0.012
histone deacetylation GO:0016575 32 0.012
regulation of multicellular organism growth GO:0040014 8 0.012
single organism behavior GO:0044708 28 0.012
Fly
adult behavior GO:0030534 18 0.012
Fly
neuron projection extension GO:1990138 14 0.012
translational initiation GO:0006413 48 0.012
positive regulation of kinase activity GO:0033674 204 0.012
epidermal growth factor receptor signaling pathway GO:0007173 39 0.012
Fly
positive regulation of developmental growth GO:0048639 16 0.012
cell adhesion GO:0007155 325 0.011
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.011
cellular response to cytokine stimulus GO:0071345 181 0.011
negative regulation of protein transport GO:0051224 75 0.011
regulation of cell activation GO:0050865 125 0.011
negative regulation of nuclear division GO:0051784 25 0.011
positive regulation of cell projection organization GO:0031346 64 0.011
trophectodermal cell differentiation GO:0001829 3 0.011
positive regulation of lymphocyte activation GO:0051251 73 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
macromolecule deacylation GO:0098732 41 0.011
glycoprotein metabolic process GO:0009100 110 0.011
transmission of nerve impulse GO:0019226 11 0.011
embryonic organ morphogenesis GO:0048562 24 0.011
response to abiotic stimulus GO:0009628 336 0.011
glycosylation GO:0070085 71 0.011
regulation of kinase activity GO:0043549 314 0.011
regulation of establishment of protein localization GO:0070201 242 0.011
microtubule nucleation GO:0007020 6 0.011
positive regulation of translational initiation GO:0045948 7 0.011
central nervous system development GO:0007417 123 0.011
stem cell division GO:0017145 2 0.011
positive regulation of immune system process GO:0002684 283 0.011
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.011
multicellular organism growth GO:0035264 8 0.011
regulation of nucleoside metabolic process GO:0009118 209 0.011
ribose phosphate biosynthetic process GO:0046390 82 0.010
forelimb morphogenesis GO:0035136 4 0.010
regulation of mrna stability GO:0043488 23 0.010
regulation of dephosphorylation GO:0035303 96 0.010
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.010
detection of mechanical stimulus involved in sensory perception GO:0050974 1 0.010
protein homooligomerization GO:0051260 100 0.010
glycoprotein biosynthetic process GO:0009101 91 0.010
rab protein signal transduction GO:0032482 4 0.010
protein methylation GO:0006479 74 0.010
tissue homeostasis GO:0001894 63 0.010
cellular response to extracellular stimulus GO:0031668 72 0.010
cell growth GO:0016049 160 0.010

PUM2 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.023
nervous system disease DOID:863 431 0.023
neurodegenerative disease DOID:1289 102 0.019
cancer DOID:162 167 0.015
disease of cellular proliferation DOID:14566 174 0.015
organ system cancer DOID:0050686 164 0.015