|
positive regulation of camp biosynthetic process
|
GO:0030819 |
35 |
0.982
|
Yeast |
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.893
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.880
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
38 |
0.865
|
Yeast |
|
negative regulation of rho gtpase activity
|
GO:0034259 |
4 |
0.840
|
Human |
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.832
|
Yeast |
|
positive regulation of adenylate cyclase activity
|
GO:0045762 |
12 |
0.823
|
Yeast |
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.821
|
Human |
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.800
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.762
|
|
|
camp biosynthetic process
|
GO:0006171 |
47 |
0.762
|
Yeast |
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.761
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.759
|
Human |
|
positive regulation of rac gtpase activity
|
GO:0032855 |
31 |
0.749
|
Human |
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.748
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.747
|
Human Yeast |
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.720
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.720
|
Human |
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.719
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.715
|
Human Yeast |
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.708
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.702
|
|
|
purine ribonucleoside monophosphate catabolic process
|
GO:0009169 |
158 |
0.691
|
|
|
positive regulation of cyclic nucleotide biosynthetic process
|
GO:0030804 |
38 |
0.669
|
Yeast |
|
regulation of cyclase activity
|
GO:0031279 |
19 |
0.661
|
Yeast |
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.640
|
|
|
cdc42 protein signal transduction
|
GO:0032488 |
4 |
0.633
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.631
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.629
|
Human |
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.629
|
Human |
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.617
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.608
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.604
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.602
|
Human Yeast |
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.579
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.573
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.573
|
Human |
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.558
|
Human |
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.537
|
|
|
atp catabolic process
|
GO:0006200 |
157 |
0.535
|
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
61 |
0.531
|
Yeast |
|
regulation of adenylate cyclase activity
|
GO:0045761 |
17 |
0.530
|
Yeast |
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.507
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.492
|
Human Fly |
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.489
|
Human |
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.485
|
Human |
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.472
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.465
|
Human |
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.462
|
Human Yeast |
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.457
|
|
|
nucleoside monophosphate catabolic process
|
GO:0009125 |
159 |
0.454
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.443
|
Human |
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.436
|
Human |
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
0.432
|
Yeast |
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.425
|
Human |
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.422
|
Human |
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.414
|
Human |
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.405
|
Yeast |
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.398
|
Human |
|
regulation of locomotion
|
GO:0040012 |
329 |
0.389
|
Human |
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.386
|
Yeast |
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.380
|
Human |
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.372
|
Human |
|
atp metabolic process
|
GO:0046034 |
176 |
0.370
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.362
|
Human |
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.360
|
Human |
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.339
|
Human |
|
positive regulation of camp metabolic process
|
GO:0030816 |
41 |
0.326
|
Yeast |
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.321
|
Human |
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.318
|
Yeast |
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.317
|
Human |
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.313
|
|
|
regulation of nucleotide biosynthetic process
|
GO:0030808 |
50 |
0.310
|
Yeast |
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.303
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.302
|
Human |
|
positive regulation of cytoskeleton organization
|
GO:0051495 |
83 |
0.293
|
Human |
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.292
|
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.267
|
Yeast |
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.265
|
Human |
|
positive regulation of ryanodine sensitive calcium release channel activity
|
GO:0060316 |
6 |
0.265
|
|
|
camp metabolic process
|
GO:0046058 |
61 |
0.260
|
Yeast |
|
regulation of camp metabolic process
|
GO:0030814 |
52 |
0.258
|
Yeast |
|
regulation of camp biosynthetic process
|
GO:0030817 |
45 |
0.257
|
Yeast |
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.256
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.252
|
Human |
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.247
|
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.246
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.231
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.227
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.220
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.209
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.203
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.196
|
Worm Fly |
|
smooth muscle cell proliferation
|
GO:0048659 |
28 |
0.196
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.196
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.195
|
Human |
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.186
|
|
|
secretion
|
GO:0046903 |
254 |
0.184
|
Human |
|
positive regulation of cyclic nucleotide metabolic process
|
GO:0030801 |
49 |
0.184
|
Yeast |
|
negative regulation of smooth muscle cell proliferation
|
GO:0048662 |
14 |
0.182
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.180
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.177
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.177
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.175
|
Yeast |
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.167
|
Human |
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.162
|
Fly |
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.162
|
Human |
|
actin filament based process
|
GO:0030029 |
224 |
0.156
|
Human |
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.153
|
Human |
|
muscle cell proliferation
|
GO:0033002 |
35 |
0.151
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.151
|
Human |
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.149
|
|
|
membrane raft localization
|
GO:0051665 |
1 |
0.149
|
Human |
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.148
|
|
|
regulation of wound healing
|
GO:0061041 |
56 |
0.145
|
Human |
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.144
|
|
|
neural tube patterning
|
GO:0021532 |
2 |
0.144
|
|
|
positive regulation of lyase activity
|
GO:0051349 |
16 |
0.143
|
Yeast |
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.142
|
Human |
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.141
|
Yeast |
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.139
|
Human Fly |
|
endomembrane system organization
|
GO:0010256 |
196 |
0.138
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.137
|
Fly |
|
immune response
|
GO:0006955 |
307 |
0.137
|
Fly |
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.136
|
Human |
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.133
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.133
|
Worm |
|
notch signaling pathway
|
GO:0007219 |
31 |
0.127
|
Fly |
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.124
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.124
|
Human |
|
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
|
GO:0010880 |
10 |
0.124
|
|
|
positive regulation of cyclic nucleotide phosphodiesterase activity
|
GO:0051343 |
4 |
0.120
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.120
|
Worm Fly |
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.117
|
Human |
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.116
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.115
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.113
|
|
|
exocytosis
|
GO:0006887 |
71 |
0.110
|
Human |
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.108
|
Yeast |
|
regulation of heart rate
|
GO:0002027 |
38 |
0.108
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.105
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.104
|
Human |
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.102
|
Human Fly |
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.101
|
Human |
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.101
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.099
|
|
|
muscle system process
|
GO:0003012 |
81 |
0.099
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.098
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.097
|
Fly |
|
actin filament polymerization
|
GO:0030041 |
45 |
0.096
|
|
|
system process
|
GO:0003008 |
349 |
0.094
|
|
|
regulation of ryanodine sensitive calcium release channel activity
|
GO:0060314 |
12 |
0.094
|
|
|
positive regulation of cyclase activity
|
GO:0031281 |
13 |
0.093
|
Yeast |
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.093
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.092
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.092
|
Human Fly |
|
cation transport
|
GO:0006812 |
331 |
0.092
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.091
|
Fly |
|
cell projection assembly
|
GO:0030031 |
126 |
0.091
|
Human |
|
mapk cascade
|
GO:0000165 |
288 |
0.089
|
Human Fly |
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.089
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.088
|
Human |
|
ossification
|
GO:0001503 |
121 |
0.088
|
Human |
|
regulation of filopodium assembly
|
GO:0051489 |
13 |
0.088
|
Human |
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.088
|
|
|
organelle inheritance
|
GO:0048308 |
2 |
0.087
|
|
|
defense response
|
GO:0006952 |
315 |
0.087
|
Fly |
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.087
|
Human |
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.087
|
Fly |
|
regulation of ruffle assembly
|
GO:1900027 |
8 |
0.086
|
Human |
|
positive regulation of purine nucleotide biosynthetic process
|
GO:1900373 |
38 |
0.086
|
Yeast |
|
response to bacterium
|
GO:0009617 |
144 |
0.086
|
Fly |
|
chemical homeostasis
|
GO:0048878 |
306 |
0.085
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.084
|
Yeast |
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.084
|
Worm |
|
circulatory system process
|
GO:0003013 |
113 |
0.083
|
|
|
detection of chemical stimulus
|
GO:0009593 |
55 |
0.082
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.080
|
Yeast |
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.079
|
Human |
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.079
|
|
|
heart process
|
GO:0003015 |
62 |
0.079
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.078
|
Human Fly |
|
calcium ion transmembrane transport
|
GO:0070588 |
76 |
0.078
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.078
|
|
|
positive regulation of cdc42 gtpase activity
|
GO:0043089 |
6 |
0.077
|
|
|
positive regulation of actin filament polymerization
|
GO:0030838 |
38 |
0.077
|
|
|
muscle contraction
|
GO:0006936 |
73 |
0.076
|
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.076
|
Yeast |
|
cell division
|
GO:0051301 |
168 |
0.075
|
|
|
sa node cell action potential
|
GO:0086015 |
1 |
0.075
|
|
|
heart contraction
|
GO:0060047 |
62 |
0.074
|
|
|
positive regulation of transcription by galactose
|
GO:0000411 |
1 |
0.073
|
Yeast |
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.073
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.073
|
|
|
protein processing
|
GO:0016485 |
226 |
0.073
|
|
|
regulation of circadian sleep wake cycle
|
GO:0042749 |
2 |
0.071
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.071
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.070
|
Human |
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.070
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.070
|
Human Worm |
|
regulation of cell motility
|
GO:2000145 |
299 |
0.069
|
Human |
|
endosomal transport
|
GO:0016197 |
129 |
0.069
|
|
|
regulation of cyclic nucleotide phosphodiesterase activity
|
GO:0051342 |
4 |
0.068
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.068
|
Human |
|
detection of stimulus
|
GO:0051606 |
85 |
0.066
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.066
|
Human |
|
microtubule based process
|
GO:0007017 |
210 |
0.066
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.066
|
|
|
positive regulation of angiogenesis
|
GO:0045766 |
51 |
0.066
|
Human |
|
epithelial fluid transport
|
GO:0042045 |
1 |
0.066
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.066
|
Human |
|
membrane organization
|
GO:0061024 |
292 |
0.066
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.065
|
|
|
regulation of cardiac muscle contraction
|
GO:0055117 |
33 |
0.065
|
|
|
carbon catabolite activation of transcription
|
GO:0045991 |
3 |
0.065
|
Yeast |
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.064
|
Human |
|
blood circulation
|
GO:0008015 |
113 |
0.063
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.062
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.061
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.061
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.060
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.060
|
Human Fly |
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.060
|
|
|
regulation of exocytosis
|
GO:0017157 |
46 |
0.059
|
Human |
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.059
|
Human Yeast |
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.059
|
Human |
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.059
|
Human |
|
regulation of cdc42 protein signal transduction
|
GO:0032489 |
14 |
0.058
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.058
|
Human |
|
negative regulation of ras gtpase activity
|
GO:0034261 |
6 |
0.058
|
Human |
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.058
|
Human |
|
detection of calcium ion
|
GO:0005513 |
8 |
0.058
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.058
|
Yeast |
|
cell morphogenesis
|
GO:0000902 |
296 |
0.057
|
Fly |
|
angiogenesis
|
GO:0001525 |
147 |
0.057
|
Human |
|
circulatory system development
|
GO:0072359 |
262 |
0.057
|
Human |
|
regulation of growth
|
GO:0040008 |
165 |
0.056
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.056
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.056
|
|
|
actin filament capping
|
GO:0051693 |
4 |
0.055
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.055
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.054
|
Human Fly |
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.054
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.054
|
Human Fly |
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.053
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.052
|
|
|
regulation of cdc42 gtpase activity
|
GO:0043088 |
10 |
0.052
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.052
|
Human |
|
engulfment of apoptotic cell
|
GO:0043652 |
2 |
0.052
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.052
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.051
|
|
|
cardiac muscle cell action potential
|
GO:0086001 |
23 |
0.051
|
|
|
negative regulation of voltage gated calcium channel activity
|
GO:1901386 |
4 |
0.051
|
|
|
membrane repolarization during sa node cell action potential
|
GO:0086052 |
1 |
0.051
|
|
|
growth
|
GO:0040007 |
202 |
0.050
|
Yeast |
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.050
|
|
|
regulation of striated muscle contraction
|
GO:0006942 |
37 |
0.050
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.050
|
Human Fly |
|
single organism membrane fusion
|
GO:0044801 |
37 |
0.050
|
|
|
regulation of cation channel activity
|
GO:2001257 |
33 |
0.049
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.049
|
Yeast |
|
organelle assembly
|
GO:0070925 |
176 |
0.048
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.048
|
|
|
regulation of calcium ion transmembrane transport
|
GO:1903169 |
28 |
0.048
|
|
|
ncrna metabolic process
|
GO:0034660 |
108 |
0.048
|
Human |
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.048
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.048
|
Worm |
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.048
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.047
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.047
|
Fly |
|
regulation of ion transport
|
GO:0043269 |
189 |
0.047
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.047
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.046
|
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
49 |
0.046
|
Yeast |
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.046
|
Human |
|
positive regulation of wound healing
|
GO:0090303 |
20 |
0.046
|
Human |
|
actin polymerization or depolymerization
|
GO:0008154 |
56 |
0.045
|
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.044
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.044
|
Human |
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.044
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.044
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.044
|
Human |
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.044
|
|
|
regulation of calcium ion transmembrane transporter activity
|
GO:1901019 |
28 |
0.043
|
|
|
negative regulation of stress activated protein kinase signaling cascade
|
GO:0070303 |
19 |
0.043
|
Fly |
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.043
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.042
|
|
|
membrane repolarization
|
GO:0086009 |
23 |
0.042
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.041
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.041
|
Yeast |
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.041
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.041
|
Fly |
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.041
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.041
|
|
|
defense response to gram negative bacterium
|
GO:0050829 |
14 |
0.040
|
Fly |
|
endosome to lysosome transport
|
GO:0008333 |
21 |
0.040
|
|
|
regulation of muscle contraction
|
GO:0006937 |
45 |
0.039
|
|
|
actin mediated cell contraction
|
GO:0070252 |
12 |
0.039
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.039
|
|
|
regulation of lyase activity
|
GO:0051339 |
23 |
0.039
|
Yeast |
|
positive regulation of transporter activity
|
GO:0032411 |
32 |
0.038
|
|
|
cell development
|
GO:0048468 |
328 |
0.038
|
Yeast Worm Fly |
|
negative regulation of sequestering of calcium ion
|
GO:0051283 |
41 |
0.038
|
|
|
cellular amide metabolic process
|
GO:0043603 |
69 |
0.037
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.037
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.037
|
Fly |
|
protein secretion
|
GO:0009306 |
98 |
0.037
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.037
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.037
|
Human |
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.036
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.036
|
Fly |
|
single organism membrane organization
|
GO:0044802 |
268 |
0.036
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.036
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.035
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.035
|
|
|
neural nucleus development
|
GO:0048857 |
47 |
0.035
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.034
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.034
|
|
|
positive regulation of ion transmembrane transporter activity
|
GO:0032414 |
29 |
0.034
|
|
|
regulation of interleukin 8 secretion
|
GO:2000482 |
13 |
0.034
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.034
|
Fly |
|
positive regulation of dna replication
|
GO:0045740 |
35 |
0.034
|
Human |
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.033
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.033
|
|
|
regulation of sequestering of calcium ion
|
GO:0051282 |
41 |
0.033
|
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
2 |
0.033
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.033
|
Human |
|
endoplasmic reticulum to cytosol transport
|
GO:1903513 |
13 |
0.032
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.032
|
|
|
regulation of mitotic cell cycle phase transition
|
GO:1901990 |
118 |
0.032
|
Human |
|
regulation of potassium ion export
|
GO:1902302 |
1 |
0.032
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.031
|
Human |
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
56 |
0.031
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.031
|
Fly |
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.031
|
Yeast |
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.031
|
Human |
|
cytokine production
|
GO:0001816 |
247 |
0.031
|
|
|
midbrain development
|
GO:0030901 |
45 |
0.030
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.030
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.030
|
Human Fly |
|
calcium ion transport from endoplasmic reticulum to cytosol
|
GO:1903514 |
13 |
0.030
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.030
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.030
|
Fly |
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.030
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.030
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.030
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.030
|
Fly |
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.030
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.030
|
Human |
|
response to cytokine
|
GO:0034097 |
232 |
0.030
|
|
|
positive regulation of protein polymerization
|
GO:0032273 |
45 |
0.030
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.029
|
Yeast |
|
negative regulation of potassium ion export
|
GO:1902303 |
1 |
0.029
|
|
|
autophagy
|
GO:0006914 |
88 |
0.029
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.029
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.029
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.029
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.029
|
Human |
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.029
|
|
|
regulation of actin filament length
|
GO:0030832 |
56 |
0.028
|
|
|
response to disaccharide
|
GO:0034285 |
1 |
0.028
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.028
|
Human |
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.028
|
|
|
jnk cascade
|
GO:0007254 |
80 |
0.028
|
Human Fly |
|
mitochondrion distribution
|
GO:0048311 |
3 |
0.028
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.028
|
Human |
|
metal ion transport
|
GO:0030001 |
272 |
0.028
|
|
|
cellular response to corticotropin releasing hormone stimulus
|
GO:0071376 |
1 |
0.028
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.028
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.028
|
Human |
|
intracellular protein transport
|
GO:0006886 |
270 |
0.028
|
|
|
regulation of heart rate by cardiac conduction
|
GO:0086091 |
19 |
0.028
|
|
|
cell activation
|
GO:0001775 |
213 |
0.028
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.027
|
Human |
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.027
|
Fly |
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.027
|
Worm |
|
neurotransmitter secretion
|
GO:0007269 |
4 |
0.027
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.027
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.027
|
Yeast |
|
dephosphorylation
|
GO:0016311 |
209 |
0.027
|
|
|
regulation of phosphatase activity
|
GO:0010921 |
81 |
0.027
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.027
|
|
|
regulation of cell projection assembly
|
GO:0060491 |
47 |
0.027
|
Human |
|
striated muscle contraction
|
GO:0006941 |
52 |
0.026
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.026
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
59 |
0.026
|
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.026
|
Human |
|
spindle organization
|
GO:0007051 |
53 |
0.026
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.026
|
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.026
|
Human |
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
41 |
0.026
|
|
|
negative regulation of stress activated mapk cascade
|
GO:0032873 |
19 |
0.026
|
Fly |
|
segmentation
|
GO:0035282 |
4 |
0.025
|
|
|
interleukin 8 production
|
GO:0032637 |
51 |
0.025
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.025
|
Fly |
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.025
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.025
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.025
|
|
|
cell aging
|
GO:0007569 |
52 |
0.025
|
Human Yeast |
|
cytokinesis
|
GO:0000910 |
96 |
0.025
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.025
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.024
|
Human |
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.024
|
|
|
regulation of mirna metabolic process
|
GO:2000628 |
5 |
0.024
|
Human |
|
nuclear division
|
GO:0000280 |
128 |
0.024
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.024
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.024
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.023
|
|
|
head development
|
GO:0060322 |
108 |
0.023
|
Human |
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.023
|
Human |
|
response to radiation
|
GO:0009314 |
151 |
0.023
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.023
|
|
|
positive regulation of transmembrane transport
|
GO:0034764 |
41 |
0.023
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.023
|
|
|
positive regulation of phosphoprotein phosphatase activity
|
GO:0032516 |
9 |
0.023
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.022
|
|
|
regulation of neurotransmitter secretion
|
GO:0046928 |
3 |
0.022
|
|
|
membrane repolarization during action potential
|
GO:0086011 |
8 |
0.022
|
|
|
cellular response to glucocorticoid stimulus
|
GO:0071385 |
4 |
0.022
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.022
|
|
|
regulation of release of sequestered calcium ion into cytosol
|
GO:0051279 |
27 |
0.022
|
|
|
cilium assembly
|
GO:0042384 |
63 |
0.022
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.022
|
Human |
|
protein catabolic process
|
GO:0030163 |
325 |
0.022
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.021
|
|
|
protein kinase b signaling
|
GO:0043491 |
69 |
0.021
|
Human |
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.021
|
Human |
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.021
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.021
|
Yeast |
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.021
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.021
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.021
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.021
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.021
|
Fly |
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.021
|
|
|
dna replication
|
GO:0006260 |
116 |
0.021
|
Human |
|
cell adhesion
|
GO:0007155 |
325 |
0.021
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.021
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.021
|
|
|
sarcoplasmic reticulum calcium ion transport
|
GO:0070296 |
13 |
0.021
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.021
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.021
|
Yeast Worm |
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.021
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.021
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.021
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.021
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.021
|
Human |
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.020
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.020
|
|
|
protein dephosphorylation
|
GO:0006470 |
81 |
0.020
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.020
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.020
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.020
|
Human |
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.020
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.020
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.020
|
|
|
positive regulation of ion transmembrane transport
|
GO:0034767 |
40 |
0.020
|
|
|
regulation of muscle system process
|
GO:0090257 |
53 |
0.020
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.020
|
|
|
activation of adenylate cyclase activity
|
GO:0007190 |
5 |
0.020
|
Yeast |
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.020
|
|
|
synaptic vesicle exocytosis
|
GO:0016079 |
3 |
0.020
|
|
|
blood coagulation
|
GO:0007596 |
76 |
0.020
|
|
|
synaptic transmission cholinergic
|
GO:0007271 |
2 |
0.019
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.019
|
Fly |
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.019
|
|
|
adult locomotory behavior
|
GO:0008344 |
1 |
0.019
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.019
|
|
|
negative regulation of jnk cascade
|
GO:0046329 |
16 |
0.019
|
Fly |
|
plasma membrane organization
|
GO:0007009 |
115 |
0.019
|
|
|
cardiac muscle cell contraction
|
GO:0086003 |
4 |
0.019
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.019
|
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.019
|
|
|
receptor metabolic process
|
GO:0043112 |
81 |
0.019
|
|
|
cell growth
|
GO:0016049 |
160 |
0.019
|
Yeast |
|
actin nucleation
|
GO:0045010 |
21 |
0.019
|
|
|
cellular sodium ion homeostasis
|
GO:0006883 |
8 |
0.019
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.019
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.019
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.019
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.019
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.018
|
Yeast |
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.018
|
Human |
|
replicative cell aging
|
GO:0001302 |
3 |
0.018
|
Yeast |
|
compound eye development
|
GO:0048749 |
1 |
0.018
|
Fly |
|
cofactor metabolic process
|
GO:0051186 |
87 |
0.018
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.018
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.018
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.018
|
|