|
|
cellular response to muramyl dipeptide
|
GO:0071225 |
3 |
1.000
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
1.000
|
|
|
|
detection of muramyl dipeptide
|
GO:0032498 |
1 |
1.000
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
1.000
|
|
|
|
positive regulation of mhc class i biosynthetic process
|
GO:0045345 |
4 |
1.000
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
1.000
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
1.000
|
Human Mouse |
|
|
positive regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903557 |
22 |
0.999
|
Human Mouse |
|
|
positive regulation of interleukin 1 beta secretion
|
GO:0050718 |
11 |
0.999
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.998
|
Mouse |
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.998
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.998
|
|
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
24 |
0.997
|
Human |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.997
|
Human Mouse |
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.996
|
Human Mouse |
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.994
|
Human Mouse |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.990
|
Human Mouse |
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.989
|
Human Mouse |
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.986
|
|
|
|
interleukin 8 production
|
GO:0032637 |
51 |
0.986
|
Human |
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.985
|
Human Mouse |
|
|
innate immune response
|
GO:0045087 |
178 |
0.984
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.983
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.980
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.977
|
Human Mouse |
|
|
positive regulation of production of molecular mediator of immune response
|
GO:0002702 |
11 |
0.975
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.974
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.973
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.971
|
Human Mouse |
|
|
regulation of macrophage differentiation
|
GO:0045649 |
9 |
0.968
|
Human |
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.962
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.960
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.957
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.955
|
Human Mouse |
|
|
toll like receptor 2 signaling pathway
|
GO:0034134 |
4 |
0.950
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.947
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.940
|
Human |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.933
|
Human |
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.931
|
|
|
|
detection of peptidoglycan
|
GO:0032499 |
1 |
0.930
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.929
|
Mouse |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.928
|
Human |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.927
|
Human |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.924
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.917
|
|
|
|
activation of innate immune response
|
GO:0002218 |
55 |
0.914
|
|
|
|
nucleotide binding oligomerization domain containing 2 signaling pathway
|
GO:0070431 |
4 |
0.910
|
|
|
|
detection of stimulus
|
GO:0051606 |
85 |
0.906
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.894
|
Human Mouse |
|
|
mhc class i biosynthetic process
|
GO:0045341 |
4 |
0.893
|
|
|
|
peptidyl serine autophosphorylation
|
GO:0036289 |
2 |
0.891
|
Human |
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.891
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.885
|
Mouse |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.883
|
Human |
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.882
|
Human |
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.874
|
Mouse |
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.867
|
Human Mouse |
|
|
negative regulation of i kappab kinase nf kappab signaling
|
GO:0043124 |
32 |
0.867
|
Human |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.858
|
Human |
|
|
detection of biotic stimulus
|
GO:0009595 |
21 |
0.856
|
|
|
|
detection of other organism
|
GO:0098543 |
13 |
0.852
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.850
|
Mouse |
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.837
|
Mouse |
|
|
nucleotide binding domain leucine rich repeat containing receptor signaling pathway
|
GO:0035872 |
5 |
0.835
|
|
|
|
detection of external biotic stimulus
|
GO:0098581 |
19 |
0.823
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.820
|
|
|
|
interleukin 1 beta secretion
|
GO:0050702 |
15 |
0.814
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.808
|
Human |
|
|
positive regulation of tumor necrosis factor production
|
GO:0032760 |
21 |
0.792
|
Human Mouse |
|
|
positive regulation of interleukin 6 production
|
GO:0032755 |
21 |
0.782
|
Mouse |
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.780
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.780
|
Human Mouse |
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.780
|
Human |
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.777
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
38 |
0.775
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.768
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.767
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.747
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.745
|
Mouse |
|
|
innate immune response activating signal transduction
|
GO:0002758 |
48 |
0.737
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.722
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.715
|
Mouse |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.709
|
Human Mouse |
|
|
protein heterooligomerization
|
GO:0051291 |
16 |
0.703
|
Human |
|
|
interleukin 1 beta production
|
GO:0032611 |
22 |
0.700
|
|
|
|
regulation of interleukin 1 secretion
|
GO:0050704 |
14 |
0.691
|
|
|
|
regulation of interleukin 1 beta secretion
|
GO:0050706 |
12 |
0.690
|
|
|
|
detection of bacterium
|
GO:0016045 |
13 |
0.688
|
|
|
|
positive regulation of necroptotic process
|
GO:0060545 |
2 |
0.682
|
Human |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.680
|
Human |
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.679
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.678
|
Human Mouse |
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.660
|
|
|
|
positive regulation of interleukin 1 beta production
|
GO:0032731 |
13 |
0.660
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.651
|
|
|
|
nucleotide binding oligomerization domain containing signaling pathway
|
GO:0070423 |
4 |
0.648
|
|
|
|
regulation of mhc class i biosynthetic process
|
GO:0045343 |
4 |
0.634
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.625
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.624
|
Human Mouse |
|
|
release of cytoplasmic sequestered nf kappab
|
GO:0008588 |
4 |
0.617
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.617
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.616
|
|
|
|
interleukin 1 secretion
|
GO:0050701 |
18 |
0.614
|
|
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.614
|
Human |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.608
|
Human Mouse |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.607
|
Human |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.603
|
Human Mouse |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.592
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.589
|
Human Mouse |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.587
|
Human |
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.575
|
Human |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.569
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.560
|
|
|
|
positive regulation of interleukin 1 production
|
GO:0032732 |
14 |
0.552
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.552
|
Mouse |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.548
|
Human |
|
|
positive regulation of protein polyubiquitination
|
GO:1902916 |
3 |
0.544
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.540
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.540
|
|
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.536
|
Mouse |
|
|
signal transduction involved in mitotic dna damage checkpoint
|
GO:1902402 |
13 |
0.520
|
|
|
|
regulation of nucleoside transport
|
GO:0032242 |
1 |
0.510
|
Human |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.501
|
Human |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.497
|
|
|
|
interleukin 1 production
|
GO:0032612 |
26 |
0.496
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.496
|
|
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.494
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.493
|
Mouse |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.489
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.487
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.484
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.472
|
|
|
|
regulation of protein monoubiquitination
|
GO:1902525 |
1 |
0.471
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.470
|
|
|
|
positive regulation of humoral immune response
|
GO:0002922 |
3 |
0.457
|
|
|
|
carbohydrate derivative transport
|
GO:1901264 |
20 |
0.454
|
Human |
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.442
|
|
|
|
regulation of protein linear polyubiquitination
|
GO:1902528 |
2 |
0.435
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.426
|
Mouse |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.424
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.409
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.404
|
Mouse |
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.401
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.397
|
Human |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.395
|
|
|
|
positive regulation of interleukin 17 production
|
GO:0032740 |
8 |
0.395
|
|
|
|
trail activated apoptotic signaling pathway
|
GO:0036462 |
4 |
0.392
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.381
|
|
|
|
regulation of interleukin 8 production
|
GO:0032677 |
49 |
0.378
|
Human |
|
|
positive regulation of cytokine production involved in immune response
|
GO:0002720 |
6 |
0.373
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.371
|
Human Mouse |
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.370
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.362
|
|
|
|
negative regulation of interleukin 6 biosynthetic process
|
GO:0045409 |
3 |
0.358
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.357
|
Human |
|
|
positive regulation of protein linear polyubiquitination
|
GO:1902530 |
2 |
0.356
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.353
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
24 |
0.352
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.343
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.341
|
Mouse |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.335
|
|
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.333
|
Human |
|
|
type i interferon signaling pathway
|
GO:0060337 |
11 |
0.331
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.329
|
Human Mouse |
|
|
pattern recognition receptor signaling pathway
|
GO:0002221 |
48 |
0.323
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.321
|
Human Mouse |
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.319
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.313
|
Mouse |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.308
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.308
|
Human |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.308
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.302
|
Human Mouse |
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.300
|
Human |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.300
|
|
|
|
dendritic cell antigen processing and presentation
|
GO:0002468 |
1 |
0.297
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.293
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.292
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.288
|
Mouse |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.285
|
Mouse |
|
|
defense response to virus
|
GO:0051607 |
71 |
0.280
|
|
|
|
b cell homeostasis
|
GO:0001782 |
1 |
0.279
|
|
|
|
nucleoside transport
|
GO:0015858 |
8 |
0.270
|
Human |
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
9 |
0.268
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.264
|
Human Mouse |
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.263
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.262
|
Mouse |
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.262
|
|
|
|
circadian sleep wake cycle sleep
|
GO:0050802 |
2 |
0.261
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.258
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.257
|
|
|
|
dna damage checkpoint
|
GO:0000077 |
68 |
0.257
|
|
|
|
detection of molecule of bacterial origin
|
GO:0032490 |
10 |
0.255
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.255
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway
|
GO:2001269 |
1 |
0.253
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.250
|
Mouse |
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.248
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.243
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.243
|
Mouse |
|
|
protein processing
|
GO:0016485 |
226 |
0.241
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.238
|
Human |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.235
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.235
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.234
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.228
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.228
|
Human Mouse |
|
|
mitotic g1 s transition checkpoint
|
GO:0044819 |
17 |
0.226
|
|
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
4 |
0.225
|
Human |
|
|
ripoptosome assembly
|
GO:0097343 |
1 |
0.224
|
Human |
|
|
neurological system process
|
GO:0050877 |
163 |
0.224
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.222
|
Mouse |
|
|
compound eye development
|
GO:0048749 |
1 |
0.222
|
|
|
|
mitotic g1 dna damage checkpoint
|
GO:0031571 |
17 |
0.219
|
|
|
|
regulation of transcription regulatory region dna binding
|
GO:2000677 |
15 |
0.217
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.216
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.213
|
Human |
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.212
|
|
|
|
natural killer cell apoptotic process
|
GO:0070246 |
1 |
0.210
|
|
|
|
acute inflammatory response
|
GO:0002526 |
21 |
0.208
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.202
|
|
|
|
intrinsic apoptotic signaling pathway in response to oxidative stress
|
GO:0008631 |
21 |
0.200
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.198
|
Human |
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.196
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.196
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.193
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.192
|
Human |
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
9 |
0.191
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.189
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.188
|
|
|
|
signal transduction involved in dna damage checkpoint
|
GO:0072422 |
15 |
0.187
|
|
|
|
response to interferon gamma
|
GO:0034341 |
39 |
0.187
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.186
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.182
|
|
|
|
response to activity
|
GO:0014823 |
0 |
0.182
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.180
|
|
|
|
regulation of lymphocyte apoptotic process
|
GO:0070228 |
15 |
0.179
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.177
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.176
|
|
|
|
signal transduction involved in mitotic g1 dna damage checkpoint
|
GO:0072431 |
10 |
0.175
|
|
|
|
regulation of interleukin 1 beta production
|
GO:0032651 |
18 |
0.173
|
|
|
|
system process
|
GO:0003008 |
349 |
0.171
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.170
|
Mouse |
|
|
response to peptidoglycan
|
GO:0032494 |
3 |
0.170
|
Mouse |
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.169
|
Human |
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.168
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.165
|
|
|
|
negative regulation of cell cycle process
|
GO:0010948 |
121 |
0.164
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.164
|
Mouse |
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.162
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.162
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.159
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.157
|
Human Mouse |
|
|
protein maturation
|
GO:0051604 |
233 |
0.154
|
|
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.153
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.151
|
Mouse |
|
|
negative regulation of cell cycle g1 s phase transition
|
GO:1902807 |
29 |
0.151
|
|
|
|
detection of chemical stimulus
|
GO:0009593 |
55 |
0.150
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.148
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.148
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.146
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.145
|
Mouse |
|
|
cellular amide metabolic process
|
GO:0043603 |
69 |
0.145
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.142
|
Human Mouse |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.141
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.141
|
Mouse |
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.140
|
|
|
|
negative regulation of interleukin 1 secretion
|
GO:0050711 |
4 |
0.140
|
|
|
|
positive regulation of protein k48 linked ubiquitination
|
GO:1902524 |
1 |
0.139
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.139
|
Human |
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.139
|
Human |
|
|
negative regulation of interleukin 1 beta secretion
|
GO:0050713 |
2 |
0.138
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.137
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.137
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.136
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.136
|
|
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.136
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.135
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.135
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.134
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.133
|
|
|
|
peptide metabolic process
|
GO:0006518 |
51 |
0.133
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.132
|
Human |
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.130
|
|
|
|
t cell cytokine production
|
GO:0002369 |
12 |
0.129
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.128
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.128
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.127
|
|
|
|
intracellular signal transduction involved in g1 dna damage checkpoint
|
GO:1902400 |
10 |
0.125
|
|
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.125
|
Human Mouse |
|
|
protein import
|
GO:0017038 |
130 |
0.124
|
|
|
|
negative regulation of g1 s transition of mitotic cell cycle
|
GO:2000134 |
29 |
0.124
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.124
|
|
|
|
positive regulation of cell cycle arrest
|
GO:0071158 |
23 |
0.124
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.123
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.123
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.122
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.122
|
|
|
|
defense response to gram positive bacterium
|
GO:0050830 |
29 |
0.121
|
Mouse |
|
|
release of cytochrome c from mitochondria
|
GO:0001836 |
35 |
0.119
|
|
|
|
midgut development
|
GO:0007494 |
1 |
0.119
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.117
|
|
|
|
protein linear polyubiquitination
|
GO:0097039 |
5 |
0.116
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.116
|
|
|
|
protein autoprocessing
|
GO:0016540 |
4 |
0.116
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.115
|
|
|
|
regulation of interleukin 1 production
|
GO:0032652 |
21 |
0.113
|
|
|
|
regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001239 |
20 |
0.113
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.112
|
|
|
|
negative regulation of acute inflammatory response
|
GO:0002674 |
3 |
0.111
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.111
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
48 |
0.110
|
|
|
|
antigen processing and presentation
|
GO:0019882 |
33 |
0.109
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.109
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.108
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.106
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.105
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.104
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.103
|
|
|
|
response to toxic substance
|
GO:0009636 |
37 |
0.102
|
|
|
|
response to hydrogen peroxide
|
GO:0042542 |
40 |
0.102
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.101
|
Human |
|
|
signal transduction involved in dna integrity checkpoint
|
GO:0072401 |
15 |
0.101
|
|
|
|
interleukin 17 production
|
GO:0032620 |
12 |
0.100
|
|
|
|
signal transduction involved in cell cycle checkpoint
|
GO:0072395 |
16 |
0.100
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.099
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.097
|
|
|
|
regulation of t cell cytokine production
|
GO:0002724 |
10 |
0.097
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.096
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.095
|
Mouse |
|
|
dna damage response signal transduction by p53 class mediator resulting in cell cycle arrest
|
GO:0006977 |
9 |
0.095
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.095
|
Mouse |
|
|
regulation of acute inflammatory response
|
GO:0002673 |
13 |
0.094
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.094
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.093
|
Human Mouse |
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.093
|
Mouse |
|
|
circadian sleep wake cycle process
|
GO:0022410 |
2 |
0.092
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.092
|
Mouse |
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.092
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.091
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.091
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.090
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.090
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.088
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.088
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.088
|
|
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.087
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.087
|
Mouse |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.087
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.087
|
|
|
|
positive regulation of protein homodimerization activity
|
GO:0090073 |
5 |
0.086
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.085
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.085
|
|
|
|
positive regulation of interferon gamma mediated signaling pathway
|
GO:0060335 |
2 |
0.085
|
|
|
|
cellular response to interferon gamma
|
GO:0071346 |
24 |
0.085
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.084
|
|
|
|
autophagic cell death
|
GO:0048102 |
3 |
0.083
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.083
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.083
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.083
|
Human |
|
|
regulation of interleukin 8 secretion
|
GO:2000482 |
13 |
0.083
|
|
|
|
signal transduction involved in mitotic dna integrity checkpoint
|
GO:1902403 |
13 |
0.082
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.082
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic signaling pathway
|
GO:2001267 |
2 |
0.081
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.081
|
|
|
|
interferon gamma mediated signaling pathway
|
GO:0060333 |
7 |
0.080
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.080
|
Human |
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
11 |
0.080
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.079
|
Mouse |
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.079
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.079
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.078
|
|
|
|
positive regulation of nf kappab import into nucleus
|
GO:0042346 |
13 |
0.077
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.077
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.076
|
|
|
|
negative regulation of reactive oxygen species metabolic process
|
GO:2000378 |
11 |
0.076
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.075
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.075
|
|
|
|
mitotic cell cycle checkpoint
|
GO:0007093 |
68 |
0.075
|
|
|
|
nucleobase containing compound transport
|
GO:0015931 |
51 |
0.073
|
Human |
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.072
|
|
|
|
regulation of oxidoreductase activity
|
GO:0051341 |
43 |
0.072
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.072
|
|
|
|
regulation of type i interferon mediated signaling pathway
|
GO:0060338 |
9 |
0.072
|
|
|
|
vasodilation
|
GO:0042311 |
4 |
0.072
|
|
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.071
|
|
|
|
midbrain development
|
GO:0030901 |
45 |
0.071
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.071
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.070
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.070
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.070
|
|
|
|
protein k48 linked ubiquitination
|
GO:0070936 |
38 |
0.069
|
|
|
|
circadian sleep wake cycle
|
GO:0042745 |
2 |
0.069
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.068
|
Mouse |
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
1 |
0.068
|
|
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.067
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.067
|
|
|
|
regulation of transcription factor import into nucleus
|
GO:0042990 |
39 |
0.067
|
|
|
|
cellular response to light stimulus
|
GO:0071482 |
34 |
0.066
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.066
|
Human |
|
|
dna integrity checkpoint
|
GO:0031570 |
71 |
0.066
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.065
|
|
|
|
regulation of leukocyte apoptotic process
|
GO:2000106 |
25 |
0.065
|
|
|
|
toll signaling pathway
|
GO:0008063 |
2 |
0.065
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.065
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.064
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.064
|
|
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
46 |
0.063
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.063
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.063
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.063
|
|
|
|
necrotic cell death
|
GO:0070265 |
21 |
0.062
|
Human |
|
|
inflammatory response
|
GO:0006954 |
79 |
0.062
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.062
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.061
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.061
|
|
|
|
regulation of dendritic cell antigen processing and presentation
|
GO:0002604 |
1 |
0.061
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.061
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.060
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
|
GO:2001240 |
16 |
0.060
|
|
|
|
positive regulation of interleukin 1 secretion
|
GO:0050716 |
11 |
0.060
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.059
|
|
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.058
|
Mouse |
|
|
post embryonic development
|
GO:0009791 |
2 |
0.058
|
|
|
|
transcription factor import into nucleus
|
GO:0042991 |
40 |
0.058
|
|
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.058
|
|
|
|
positive regulation of cdc42 gtpase activity
|
GO:0043089 |
6 |
0.057
|
|
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.057
|
|
|
|
positive regulation of cytokine mediated signaling pathway
|
GO:0001961 |
12 |
0.057
|
Mouse |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.056
|
|
|
|
regulation of dna binding
|
GO:0051101 |
37 |
0.056
|
|
|
|
fibril organization
|
GO:0097435 |
10 |
0.055
|
Human |
|
|
positive regulation of macrophage differentiation
|
GO:0045651 |
7 |
0.055
|
Human |
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.055
|
|
|
|
negative regulation of inflammatory response
|
GO:0050728 |
22 |
0.055
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.054
|
Mouse |
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.054
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.054
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.054
|
Mouse |
|
|
positive regulation of canonical wnt signaling pathway
|
GO:0090263 |
33 |
0.053
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.053
|
|
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.053
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.053
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.052
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.052
|
|
|
|
response to antibiotic
|
GO:0046677 |
15 |
0.052
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.052
|
|
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.052
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.052
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.051
|
|
|
|
defense response to gram negative bacterium
|
GO:0050829 |
14 |
0.051
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.051
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.050
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.050
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.049
|
|
|
|
positive regulation of transcription factor import into nucleus
|
GO:0042993 |
25 |
0.049
|
|
|
|
regulation of defense response to virus
|
GO:0050688 |
33 |
0.049
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.048
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.048
|
Human |
|
|
amide biosynthetic process
|
GO:0043604 |
15 |
0.048
|
|
|
|
cellular response to uv
|
GO:0034644 |
32 |
0.048
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.047
|
|
|
|
membrane hyperpolarization
|
GO:0060081 |
1 |
0.047
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.047
|
|
|
|
spermatogenesis
|
GO:0007283 |
22 |
0.047
|
|
|
|
regulation of defense response to bacterium
|
GO:1900424 |
2 |
0.046
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.046
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.046
|
|
|
|
regulation of toll signaling pathway
|
GO:0008592 |
1 |
0.046
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.046
|
|
|
|
positive regulation of b cell activation
|
GO:0050871 |
17 |
0.046
|
|
|
|
membrane protein proteolysis
|
GO:0033619 |
38 |
0.046
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.046
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.045
|
|
|
|
regulation of protein autophosphorylation
|
GO:0031952 |
15 |
0.045
|
|
|
|
negative regulation of response to cytokine stimulus
|
GO:0060761 |
25 |
0.044
|
|
|
|
regulation of protein homodimerization activity
|
GO:0043496 |
9 |
0.044
|
|
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.044
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.044
|
|
|
|
digestive system process
|
GO:0022600 |
17 |
0.044
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.044
|
|
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.044
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.044
|
|
|
|
positive regulation of response to interferon gamma
|
GO:0060332 |
2 |
0.044
|
|
|
|
male gamete generation
|
GO:0048232 |
22 |
0.043
|
|
|
|
multicellular organismal reproductive process
|
GO:0048609 |
40 |
0.043
|
|
|
|
signal transduction involved in mitotic cell cycle checkpoint
|
GO:0072413 |
13 |
0.042
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.042
|
|
|
|
regulation of necroptotic process
|
GO:0060544 |
7 |
0.042
|
Human |
