Homo sapiens

141 known processes

RNF8

ring finger protein 8

(Aliases: FLJ12013,KIAA0646)

RNF8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
chromatin organization GO:0006325 351 0.389
histone modification GO:0016570 251 0.343
protein catabolic process GO:0030163 325 0.214
protein ubiquitination GO:0016567 314 0.210
methylation GO:0032259 106 0.207
modification dependent macromolecule catabolic process GO:0043632 212 0.201
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.177
histone methylation GO:0016571 60 0.175
chromatin modification GO:0016568 298 0.148
protein polyubiquitination GO:0000209 110 0.144
cellular response to dna damage stimulus GO:0006974 379 0.141
macromolecule methylation GO:0043414 97 0.125
negative regulation of cell death GO:0060548 345 0.117
histone lysine methylation GO:0034968 50 0.112
protein methylation GO:0006479 74 0.107
protein modification by small protein conjugation GO:0032446 342 0.085
protein alkylation GO:0008213 74 0.085
cellular protein catabolic process GO:0044257 261 0.081
positive regulation of developmental process GO:0051094 314 0.078
embryonic digestive tract morphogenesis GO:0048557 2 0.073
positive regulation of cellular component organization GO:0051130 376 0.069
regulation of cell cycle GO:0051726 393 0.067
Human
response to abiotic stimulus GO:0009628 336 0.065
growth GO:0040007 202 0.064
ras protein signal transduction GO:0007265 73 0.062
protein localization to organelle GO:0033365 280 0.060
immune response GO:0006955 307 0.059
regulation of cell cycle process GO:0010564 266 0.059
Human
regulation of proteolysis GO:0030162 293 0.059
cell fate determination GO:0001709 3 0.059
small gtpase mediated signal transduction GO:0007264 78 0.058
negative regulation of apoptotic process GO:0043066 316 0.058
regulation of response to dna damage stimulus GO:2001020 94 0.057
regeneration GO:0031099 4 0.055
locomotory behavior GO:0007626 1 0.054
proteasomal protein catabolic process GO:0010498 176 0.054
actin filament based process GO:0030029 224 0.053
adult locomotory behavior GO:0008344 1 0.050
covalent chromatin modification GO:0016569 254 0.050
regulation of dna repair GO:0006282 47 0.048
i kappab kinase nf kappab signaling GO:0007249 166 0.048
regulation of kinase activity GO:0043549 314 0.048
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.047
signal transduction in response to dna damage GO:0042770 57 0.047
regulation of establishment of protein localization GO:0070201 242 0.046
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.046
secretion GO:0046903 254 0.045
negative regulation of programmed cell death GO:0043069 321 0.044
meiotic chromosome segregation GO:0045132 4 0.044
positive regulation of transport GO:0051050 336 0.043
cellular lipid metabolic process GO:0044255 303 0.042
regulation of mitotic cell cycle GO:0007346 189 0.041
Human
positive regulation of phosphorylation GO:0042327 394 0.041
cellular macromolecule catabolic process GO:0044265 380 0.039
g2 m transition of mitotic cell cycle GO:0000086 41 0.038
regulation of ras protein signal transduction GO:0046578 155 0.038
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.037
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.037
positive regulation of transferase activity GO:0051347 227 0.037
negative regulation of protein maturation GO:1903318 142 0.036
tissue regeneration GO:0042246 3 0.035
protein targeting GO:0006605 187 0.035
organelle assembly GO:0070925 176 0.035
positive regulation of programmed cell death GO:0043068 249 0.034
response to ionizing radiation GO:0010212 65 0.034
positive regulation of dna repair GO:0045739 25 0.034
system process GO:0003008 349 0.034
mitotic cell cycle GO:0000278 326 0.033
Human
regulation of protein localization GO:0032880 296 0.033
positive regulation of cell cycle GO:0045787 140 0.033
protein maturation GO:0051604 233 0.032
positive regulation of proteolysis GO:0045862 142 0.031
regulation of cell differentiation GO:0045595 393 0.031
intracellular protein transport GO:0006886 270 0.031
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.031
reactive oxygen species biosynthetic process GO:1903409 4 0.031
regulation of small gtpase mediated signal transduction GO:0051056 156 0.031
immune effector process GO:0002252 159 0.030
positive regulation of cellular amine metabolic process GO:0033240 7 0.030
dna catabolic process exonucleolytic GO:0000738 17 0.029
membrane organization GO:0061024 292 0.029
digestive system development GO:0055123 75 0.029
positive regulation of cellular component biogenesis GO:0044089 158 0.029
regulation of anatomical structure morphogenesis GO:0022603 286 0.028
single organism cellular localization GO:1902580 332 0.028
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.028
negative regulation of immune system process GO:0002683 136 0.028
neuromuscular junction development GO:0007528 3 0.027
microtubule cytoskeleton organization GO:0000226 176 0.027
positive regulation of catabolic process GO:0009896 310 0.027
lipid metabolic process GO:0006629 381 0.026
cellular amino acid metabolic process GO:0006520 116 0.026
protein deubiquitination GO:0016579 79 0.026
regulation of protein autophosphorylation GO:0031952 15 0.026
regulation of cellular response to stress GO:0080135 244 0.026
regulation of protein complex assembly GO:0043254 147 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.026
cell cycle checkpoint GO:0000075 117 0.026
Human
reactive nitrogen species metabolic process GO:2001057 3 0.026
regulation of protein catabolic process GO:0042176 155 0.025
negative regulation of transport GO:0051051 176 0.025
mitochondrion organization GO:0007005 156 0.024
regulation of protein transport GO:0051223 213 0.024
double strand break repair GO:0006302 101 0.024
negative regulation of developmental process GO:0051093 247 0.024
regulation of intracellular transport GO:0032386 195 0.024
negative regulation of catalytic activity GO:0043086 335 0.024
dna double strand break processing GO:0000729 10 0.024
defense response GO:0006952 315 0.024
actin filament based movement GO:0030048 17 0.024
lipid biosynthetic process GO:0008610 177 0.024
cellular response to abiotic stimulus GO:0071214 117 0.023
cytoplasmic transport GO:0016482 379 0.023
dna templated transcription initiation GO:0006352 35 0.023
morphogenesis of embryonic epithelium GO:0016331 4 0.023
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.023
small molecule biosynthetic process GO:0044283 157 0.023
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.023
negative regulation of phosphate metabolic process GO:0045936 267 0.022
regulation of immune response GO:0050776 201 0.022
response to nitrogen compound GO:1901698 184 0.022
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.022
regulation of leukocyte activation GO:0002694 115 0.022
establishment of protein localization to organelle GO:0072594 172 0.022
regulation of transferase activity GO:0051338 355 0.022
maintenance of location GO:0051235 112 0.022
cell growth GO:0016049 160 0.022
negative regulation of hydrolase activity GO:0051346 182 0.022
regulation of cell motility GO:2000145 299 0.022
negative regulation of protein metabolic process GO:0051248 391 0.021
regulation of cellular ketone metabolic process GO:0010565 50 0.021
negative regulation of proteolysis GO:0045861 132 0.021
dna geometric change GO:0032392 32 0.021
dephosphorylation GO:0016311 209 0.021
central nervous system development GO:0007417 123 0.021
regulation of peptidase activity GO:0052547 180 0.021
positive regulation of cell death GO:0010942 263 0.021
oocyte development GO:0048599 1 0.021
positive regulation of transcription from rna polymerase ii promoter during mitosis GO:0046022 1 0.021
posttranscriptional regulation of gene expression GO:0010608 213 0.021
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.020
regulation of protein ubiquitination GO:0031396 95 0.020
negative regulation of cell cycle GO:0045786 193 0.020
Human
neurogenesis GO:0022008 169 0.020
regulation of secretion GO:0051046 194 0.020
positive regulation of cellular catabolic process GO:0031331 284 0.020
negative regulation of cell cycle process GO:0010948 121 0.020
Human
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
positive regulation of protein phosphorylation GO:0001934 313 0.020
reactive oxygen species metabolic process GO:0072593 75 0.020
protein localization to membrane GO:0072657 160 0.020
amine metabolic process GO:0009308 44 0.020
negative regulation of intracellular signal transduction GO:1902532 183 0.020
histone h3 k4 methylation GO:0051568 27 0.020
response to radiation GO:0009314 151 0.019
negative regulation of protein modification process GO:0031400 200 0.019
regulation of growth GO:0040008 165 0.019
negative regulation of cell proliferation GO:0008285 228 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
nuclear division GO:0000280 128 0.019
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 3 0.019
secretion by cell GO:0032940 226 0.019
response to organonitrogen compound GO:0010243 156 0.019
positive regulation of nucleotide metabolic process GO:0045981 230 0.019
somitogenesis GO:0001756 2 0.018
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.018
neurological system process GO:0050877 163 0.018
blastocyst development GO:0001824 3 0.018
oocyte differentiation GO:0009994 2 0.018
nitrogen compound transport GO:0071705 191 0.018
cellular amine metabolic process GO:0044106 41 0.018
positive regulation of kinase activity GO:0033674 204 0.018
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.018
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.018
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
response to wounding GO:0009611 168 0.018
organophosphate catabolic process GO:0046434 430 0.018
regulation of double strand break repair GO:2000779 22 0.018
intracellular mrna localization GO:0008298 1 0.018
regulation of cellular component movement GO:0051270 334 0.018
defense response to other organism GO:0098542 129 0.017
multicellular organismal aging GO:0010259 3 0.017
negative regulation of transferase activity GO:0051348 124 0.017
post embryonic development GO:0009791 2 0.017
nerve development GO:0021675 4 0.017
response to other organism GO:0051707 261 0.017
regulation of meiotic cell cycle GO:0051445 4 0.017
response to oxidative stress GO:0006979 121 0.017
regulation of peptide transport GO:0090087 62 0.016
female gamete generation GO:0007292 2 0.016
wound healing GO:0042060 115 0.016
rho protein signal transduction GO:0007266 26 0.016
regulation of immunoglobulin production GO:0002637 4 0.016
response to metal ion GO:0010038 84 0.016
isotype switching GO:0045190 3 0.016
regulation of purine nucleotide metabolic process GO:1900542 264 0.016
regulation of cell cycle phase transition GO:1901987 126 0.016
Human
organic hydroxy compound metabolic process GO:1901615 147 0.016
cell activation GO:0001775 213 0.016
fatty acid derivative metabolic process GO:1901568 35 0.016
embryo development GO:0009790 123 0.016
lipid localization GO:0010876 106 0.016
positive regulation of protein complex assembly GO:0031334 86 0.016
cellular macromolecular complex assembly GO:0034622 324 0.016
response to hormone GO:0009725 175 0.016
protein processing GO:0016485 226 0.015
cellular ketone metabolic process GO:0042180 80 0.015
modification dependent protein catabolic process GO:0019941 209 0.015
detection of stimulus GO:0051606 85 0.015
methylation dependent chromatin silencing GO:0006346 3 0.015
regulation of cysteine type endopeptidase activity GO:2000116 127 0.015
cell part morphogenesis GO:0032990 137 0.015
hematopoietic stem cell differentiation GO:0060218 4 0.015
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.015
endomembrane system organization GO:0010256 196 0.015
protein modification by small protein removal GO:0070646 92 0.015
protein dephosphorylation GO:0006470 81 0.015
nuclear transport GO:0051169 179 0.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.015
pharyngeal system development GO:0060037 2 0.015
vesicle mediated transport GO:0016192 371 0.015
negative regulation of cellular protein catabolic process GO:1903363 38 0.015
regulation of reactive oxygen species metabolic process GO:2000377 41 0.015
response to external biotic stimulus GO:0043207 261 0.015
spindle checkpoint GO:0031577 26 0.015
positive regulation of apoptotic process GO:0043065 246 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.014
gtp catabolic process GO:0006184 237 0.014
zymogen activation GO:0031638 70 0.014
positive regulation of hydrolase activity GO:0051345 331 0.014
enzyme linked receptor protein signaling pathway GO:0007167 303 0.014
dna damage response detection of dna damage GO:0042769 3 0.014
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.014
response to oxygen containing compound GO:1901700 369 0.014
regulation of neuroblast proliferation GO:1902692 3 0.014
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.014
protein homooligomerization GO:0051260 100 0.013
regulation of cell development GO:0060284 161 0.013
cellular response to organonitrogen compound GO:0071417 124 0.013
blastoderm segmentation GO:0007350 2 0.013
positive regulation of protein transport GO:0051222 135 0.013
circadian behavior GO:0048512 2 0.013
positive regulation of growth GO:0045927 58 0.013
positive regulation of secretion GO:0051047 116 0.013
segmentation GO:0035282 4 0.013
negative regulation of phosphorylation GO:0042326 174 0.013
positive regulation of cellular component movement GO:0051272 181 0.013
positive regulation of mitotic cell cycle GO:0045931 60 0.013
regulation of icosanoid secretion GO:0032303 4 0.013
negative regulation of cellular component organization GO:0051129 235 0.013
regulation of nucleocytoplasmic transport GO:0046822 98 0.013
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.013
regulation of hormone levels GO:0010817 125 0.013
regulation of synaptic plasticity GO:0048167 3 0.013
cellular response to oxygen containing compound GO:1901701 276 0.013
cellular component morphogenesis GO:0032989 314 0.013
signal transduction by phosphorylation GO:0023014 297 0.013
oxidation reduction process GO:0055114 396 0.013
regulation of intracellular protein transport GO:0033157 123 0.013
response to cytokine GO:0034097 232 0.013
developmental growth GO:0048589 48 0.013
response to fungus GO:0009620 4 0.013
chromosome segregation GO:0007059 114 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.013
lymphocyte activation GO:0046649 133 0.013
negative regulation of protein catabolic process GO:0042177 59 0.013
embryonic digestive tract development GO:0048566 10 0.013
positive regulation of intracellular transport GO:0032388 104 0.013
microtubule based process GO:0007017 210 0.013
protein import GO:0017038 130 0.012
photoreceptor cell differentiation GO:0046530 2 0.012
cofactor metabolic process GO:0051186 87 0.012
mating GO:0007618 1 0.012
mrna metabolic process GO:0016071 175 0.012
positive regulation of endopeptidase activity GO:0010950 84 0.012
positive regulation of cytokine production GO:0001819 167 0.012
positive regulation of nervous system development GO:0051962 54 0.012
organic acid biosynthetic process GO:0016053 97 0.012
activation of immune response GO:0002253 114 0.012
production of molecular mediator of immune response GO:0002440 37 0.012
establishment of organelle localization GO:0051656 59 0.012
cellular response to tumor necrosis factor GO:0071356 63 0.012
regulation of nucleotide metabolic process GO:0006140 269 0.012
regulation of secretion by cell GO:1903530 177 0.012
nucleosome organization GO:0034728 66 0.012
regulation of protein kinase activity GO:0045859 289 0.012
regulation of endopeptidase activity GO:0052548 170 0.012
cilium organization GO:0044782 68 0.012
compound eye development GO:0048749 1 0.012
cell cycle phase transition GO:0044770 173 0.012
Human
limbic system development GO:0021761 3 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
cytokine production GO:0001816 247 0.012
anion transport GO:0006820 161 0.011
innate immune response GO:0045087 178 0.011
determination of adult lifespan GO:0008340 2 0.011
inner ear morphogenesis GO:0042472 4 0.011
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.011
single organism membrane organization GO:0044802 268 0.011
monocarboxylic acid metabolic process GO:0032787 185 0.011
regulation of mitotic cell cycle phase transition GO:1901990 118 0.011
Human
unsaturated fatty acid metabolic process GO:0033559 37 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
cell activation involved in immune response GO:0002263 30 0.011
regulation of dephosphorylation GO:0035303 96 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
apoptotic signaling pathway GO:0097190 268 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
immune response regulating signaling pathway GO:0002764 97 0.011
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.011
immune response activating signal transduction GO:0002757 90 0.011
spermatid differentiation GO:0048515 4 0.011
phospholipid metabolic process GO:0006644 99 0.011
peripheral nervous system development GO:0007422 2 0.011
regulation of cell migration GO:0030334 289 0.011
regulation of cellular amino acid metabolic process GO:0006521 6 0.011
regulation of transcription involved in cell fate commitment GO:0060850 6 0.011
negative regulation of organelle organization GO:0010639 126 0.011
single organism nuclear import GO:1902593 104 0.011
lymphocyte proliferation GO:0046651 70 0.011
positive regulation of immune response GO:0050778 159 0.011
organonitrogen compound biosynthetic process GO:1901566 200 0.011
regulation of dna metabolic process GO:0051052 153 0.011
dna duplex unwinding GO:0032508 30 0.011
protein autophosphorylation GO:0046777 123 0.010
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.010
purine ribonucleoside metabolic process GO:0046128 437 0.010
transmembrane transport GO:0055085 399 0.010
startle response GO:0001964 3 0.010
cell projection morphogenesis GO:0048858 129 0.010
positive regulation of cell proliferation GO:0008284 301 0.010
sequestering of metal ion GO:0051238 24 0.010
regulation of cytokine production GO:0001817 232 0.010
dna damage checkpoint GO:0000077 68 0.010
sequestering of calcium ion GO:0051208 17 0.010
carboxylic acid biosynthetic process GO:0046394 97 0.010
spermatid development GO:0007286 4 0.010
regulation of binding GO:0051098 111 0.010
neuroblast proliferation GO:0007405 4 0.010
myeloid cell differentiation GO:0030099 117 0.010
signal transduction by p53 class mediator GO:0072331 72 0.010
regulation of transcription from rna polymerase ii promoter mitotic GO:0046021 1 0.010
negative regulation of cellular catabolic process GO:0031330 83 0.010
sensory perception of pain GO:0019233 4 0.010
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 13 0.010
epithelium development GO:0060429 227 0.010
negative regulation of protein phosphorylation GO:0001933 140 0.010
regulation of protein stability GO:0031647 87 0.010
memory GO:0007613 3 0.010
regulation of protein localization to nucleus GO:1900180 85 0.010

RNF8 disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.057
disease of mental health DOID:150 70 0.023
cancer DOID:162 167 0.021
disease of cellular proliferation DOID:14566 174 0.021
central nervous system disease DOID:331 186 0.018
nervous system disease DOID:863 431 0.018
aplastic anemia DOID:12449 30 0.018
bone marrow disease DOID:4961 31 0.018
anemia DOID:2355 55 0.018
hematopoietic system disease DOID:74 100 0.018
myopathy DOID:423 104 0.017
muscular disease DOID:0080000 114 0.017
musculoskeletal system disease DOID:17 223 0.017
muscle tissue disease DOID:66 113 0.017
organ system cancer DOID:0050686 164 0.015
sensory system disease DOID:0050155 203 0.013
eye and adnexa disease DOID:1492 150 0.013
eye disease DOID:5614 149 0.013
neurodegenerative disease DOID:1289 102 0.013