Homo sapiens

81 known processes

ROCK1

Rho-associated, coiled-coil containing protein kinase 1

(Aliases: MGC43611,MGC131603,PRO0435,P160ROCK)

ROCK1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
viral budding GO:0046755 9 0.938
actin filament based process GO:0030029 224 0.854
Human Mouse Fly
actin cytoskeleton organization GO:0030036 207 0.847
Human Mouse Fly
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.729
regulation of nucleotide catabolic process GO:0030811 205 0.671
endosomal transport GO:0016197 129 0.665
post embryonic development GO:0009791 2 0.652
Worm Fly
regulation of nucleotide metabolic process GO:0006140 269 0.617
establishment of tissue polarity GO:0007164 3 0.554
Fly
rho protein signal transduction GO:0007266 26 0.523
Rat Fly
cell projection organization GO:0030030 252 0.519
Mouse Fly
regulation of gtpase activity GO:0043087 180 0.500
g protein coupled receptor signaling pathway GO:0007186 207 0.500
membrane organization GO:0061024 292 0.490
ras protein signal transduction GO:0007265 73 0.475
Rat Fly
regulation of actin filament based process GO:0032970 141 0.461
Mouse Fly
regulation of purine nucleotide metabolic process GO:1900542 264 0.434
positive regulation of gtpase activity GO:0043547 166 0.430
positive regulation of ras gtpase activity GO:0032320 117 0.420
forebrain generation of neurons GO:0021872 3 0.363
multi organism cellular process GO:0044764 156 0.355
purine ribonucleoside catabolic process GO:0046130 398 0.354
positive regulation of gtp catabolic process GO:0033126 166 0.352
cellular macromolecular complex assembly GO:0034622 324 0.345
regulation of purine nucleotide catabolic process GO:0033121 205 0.343
small gtpase mediated signal transduction GO:0007264 78 0.343
Rat Fly
actin filament based movement GO:0030048 17 0.342
Mouse Fly
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.331
actin filament organization GO:0007015 128 0.329
Fly
regulation of small gtpase mediated signal transduction GO:0051056 156 0.324
positive regulation of amine transport GO:0051954 2 0.311
regulation of cellular component biogenesis GO:0044087 281 0.286
Mouse Fly
multi organism membrane budding GO:1902592 9 0.281
late endosome to vacuole transport GO:0045324 2 0.263
positive regulation of hydrolase activity GO:0051345 331 0.253
acetylcholine transport GO:0015870 1 0.250
vacuolar transport GO:0007034 34 0.248
regulation of vesicle mediated transport GO:0060627 130 0.248
positive regulation of cellular component organization GO:0051130 376 0.240
Mouse Fly
nucleoside catabolic process GO:0009164 408 0.240
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 10 0.240
regulation of gtp catabolic process GO:0033124 180 0.235
enzyme linked receptor protein signaling pathway GO:0007167 303 0.234
maintenance of cell polarity GO:0030011 2 0.231
sensory perception GO:0007600 103 0.226
actin mediated cell contraction GO:0070252 12 0.223
Mouse Fly
neuroblast proliferation GO:0007405 4 0.221
positive regulation of protein phosphorylation GO:0001934 313 0.219
inorganic ion transmembrane transport GO:0098660 231 0.219
ribonucleoside catabolic process GO:0042454 406 0.213
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.212
neuromuscular junction development GO:0007528 3 0.203
positive regulation of rho protein signal transduction GO:0035025 4 0.202
regulation of neural precursor cell proliferation GO:2000177 4 0.192
regulation of growth rate GO:0040009 1 0.189
chromatin organization GO:0006325 351 0.188
interspecies interaction between organisms GO:0044419 156 0.187
epithelium development GO:0060429 227 0.186
gtp catabolic process GO:0006184 237 0.186
guanosine containing compound catabolic process GO:1901069 239 0.185
regulation of kinase activity GO:0043549 314 0.183
endosome to lysosome transport GO:0008333 21 0.179
neurotransmitter secretion GO:0007269 4 0.178
protein catabolic process GO:0030163 325 0.178
growth of symbiont in host GO:0044117 1 0.177
regulation of ras protein signal transduction GO:0046578 155 0.177
viral process GO:0016032 146 0.175
cation transport GO:0006812 331 0.167
bone maturation GO:0070977 5 0.167
cellular response to endogenous stimulus GO:0071495 336 0.165
positive regulation of catabolic process GO:0009896 310 0.164
regulation of cell cycle GO:0051726 393 0.163
gtp metabolic process GO:0046039 239 0.157
vesicle mediated transport GO:0016192 371 0.156
regulation of multi organism process GO:0043900 157 0.152
epithelial cell differentiation GO:0030855 141 0.150
regulation of ion transport GO:0043269 189 0.148
membrane budding GO:0006900 28 0.148
negative regulation of cellular component organization GO:0051129 235 0.147
growth of symbiont involved in interaction with host GO:0044116 2 0.146
purine nucleoside triphosphate catabolic process GO:0009146 392 0.143
regulation of cytoskeleton organization GO:0051493 177 0.142
Fly
secretion GO:0046903 254 0.142
intracellular receptor signaling pathway GO:0030522 104 0.142
inorganic cation transmembrane transport GO:0098662 194 0.140
regulation of intracellular transport GO:0032386 195 0.139
cell projection morphogenesis GO:0048858 129 0.139
Fly
positive regulation of protein kinase activity GO:0045860 190 0.139
multi organism organelle organization GO:1902590 9 0.136
nucleoside triphosphate catabolic process GO:0009143 394 0.133
positive regulation of rho gtpase activity GO:0032321 56 0.132
regulation of actin cytoskeleton organization GO:0032956 116 0.132
Fly
purine ribonucleoside metabolic process GO:0046128 437 0.130
response to growth factor GO:0070848 205 0.130
motor neuron axon guidance GO:0008045 2 0.127
metal ion transport GO:0030001 272 0.126
receptor catabolic process GO:0032801 11 0.126
negative regulation of transport GO:0051051 176 0.123
Fly
positive regulation of nucleoside metabolic process GO:0045979 186 0.116
regulation of transferase activity GO:0051338 355 0.114
positive regulation of transport GO:0051050 336 0.114
organophosphate catabolic process GO:0046434 430 0.113
glycosyl compound catabolic process GO:1901658 413 0.112
cell part morphogenesis GO:0032990 137 0.110
Fly
positive regulation of kinase activity GO:0033674 204 0.109
multicellular organismal aging GO:0010259 3 0.107
Worm
regulation of endocytosis GO:0030100 72 0.106
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.104
viral life cycle GO:0019058 132 0.102
single organism cellular localization GO:1902580 332 0.101
guanosine containing compound metabolic process GO:1901068 244 0.100
regulation of cellular component movement GO:0051270 334 0.100
positive regulation of nucleotide metabolic process GO:0045981 230 0.099
ossification involved in bone maturation GO:0043931 4 0.098
organelle assembly GO:0070925 176 0.097
glycerolipid metabolic process GO:0046486 107 0.097
ubiquitin dependent protein catabolic process GO:0006511 206 0.096
actomyosin structure organization GO:0031032 59 0.096
Human Fly
positive regulation of transferase activity GO:0051347 227 0.096
regulation of rho gtpase activity GO:0032319 66 0.095
cellular macromolecule catabolic process GO:0044265 380 0.095
epithelial cell migration GO:0010631 119 0.095
ribonucleoside triphosphate catabolic process GO:0009203 391 0.095
mitotic cytokinetic process GO:1902410 2 0.093
cerebral cortex cell migration GO:0021795 3 0.092
cellular component morphogenesis GO:0032989 314 0.090
Mouse Worm Fly
female gamete generation GO:0007292 2 0.090
Fly
organ morphogenesis GO:0009887 147 0.089
Fly
response to transforming growth factor beta GO:0071559 94 0.088
regulation of cell motility GO:2000145 299 0.086
epidermis development GO:0008544 59 0.086
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.083
cellular lipid metabolic process GO:0044255 303 0.083
cation transmembrane transport GO:0098655 238 0.082
negative regulation of cell proliferation GO:0008285 228 0.081
cytoplasmic transport GO:0016482 379 0.081
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.080
response to radiation GO:0009314 151 0.080
ion transmembrane transport GO:0034220 338 0.080
morphogenesis of an epithelium GO:0002009 60 0.079
Fly
maintenance of location GO:0051235 112 0.076
Fly
exocytosis GO:0006887 71 0.074
multi organism membrane organization GO:0044803 12 0.074
regulation of phagocytosis engulfment GO:0060099 2 0.073
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.073
chromatin assembly or disassembly GO:0006333 78 0.073
nervous system development GO:0007399 293 0.072
Fly
cellular response to growth factor stimulus GO:0071363 197 0.072
ribonucleotide catabolic process GO:0009261 405 0.070
regulation of protein localization GO:0032880 296 0.069
Fly
nucleoside triphosphate metabolic process GO:0009141 422 0.069
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.069
secretion by cell GO:0032940 226 0.068
endocytosis GO:0006897 159 0.067
neuron projection development GO:0031175 106 0.066
Fly
positive regulation of nucleotide catabolic process GO:0030813 185 0.066
primary neural tube formation GO:0014020 3 0.066
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.065
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.065
positive regulation of intracellular transport GO:0032388 104 0.064
regulation of cell development GO:0060284 161 0.063
Fly
tissue morphogenesis GO:0048729 96 0.063
Fly
regulation of protein serine threonine kinase activity GO:0071900 179 0.063
acetylcholine secretion GO:0061526 1 0.062
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.062
protein localization to organelle GO:0033365 280 0.062
lysosomal transport GO:0007041 33 0.061
purine nucleotide catabolic process GO:0006195 405 0.061
positive regulation of phosphorylation GO:0042327 394 0.060
regulation of protein complex assembly GO:0043254 147 0.060
actin cytoskeleton reorganization GO:0031532 37 0.060
Human Fly
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.060
regulation of ras gtpase activity GO:0032318 128 0.059
system process GO:0003008 349 0.059
positive regulation of exosomal secretion GO:1903543 12 0.059
purine nucleoside catabolic process GO:0006152 398 0.059
receptor metabolic process GO:0043112 81 0.057
regulation of nucleoside metabolic process GO:0009118 209 0.057
cell morphogenesis GO:0000902 296 0.057
Mouse Worm Fly
negative regulation of transmembrane transport GO:0034763 29 0.056
cell development GO:0048468 328 0.056
Mouse Fly
positive regulation of cell death GO:0010942 263 0.056
purine containing compound catabolic process GO:0072523 411 0.056
positive regulation of organelle organization GO:0010638 195 0.055
Fly
regulation of nucleocytoplasmic transport GO:0046822 98 0.055
skin development GO:0043588 76 0.055
glycerophospholipid metabolic process GO:0006650 84 0.054
ion homeostasis GO:0050801 230 0.054
cellular component assembly involved in morphogenesis GO:0010927 73 0.053
negative regulation of phosphorus metabolic process GO:0010563 267 0.052
response to light stimulus GO:0009416 87 0.052
regulation of rho protein signal transduction GO:0035023 79 0.052
mechanosensory behavior GO:0007638 4 0.052
virion assembly GO:0019068 14 0.051
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.051
organic hydroxy compound metabolic process GO:1901615 147 0.050
mitotic nuclear division GO:0007067 119 0.049
Fly
purine ribonucleotide catabolic process GO:0009154 404 0.049
regulation of secretion GO:0051046 194 0.048
protein localization to adherens junction GO:0071896 2 0.048
vesicle organization GO:0016050 62 0.048
establishment of protein localization to organelle GO:0072594 172 0.047
regulation of cytoplasmic transport GO:1903649 149 0.047
small molecule biosynthetic process GO:0044283 157 0.047
regulation of cell adhesion GO:0030155 166 0.047
Mouse
mitotic cell cycle process GO:1903047 286 0.046
Fly
morphogenesis of a polarized epithelium GO:0001738 3 0.045
Fly
cell cell junction organization GO:0045216 69 0.045
Mouse
epithelium migration GO:0090132 119 0.045
response to oxygen containing compound GO:1901700 369 0.044
negative regulation of multi organism process GO:0043901 92 0.044
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.043
ribonucleoside triphosphate metabolic process GO:0009199 412 0.043
regulation of cell migration GO:0030334 289 0.043
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.042
regulation of cellular ketone metabolic process GO:0010565 50 0.042
embryo development GO:0009790 123 0.042
Worm Fly
skeletal system development GO:0001501 79 0.042
establishment of planar polarity GO:0001736 3 0.042
Fly
intracellular protein transport GO:0006886 270 0.042
nitrogen compound transport GO:0071705 191 0.042
regulation of cell growth GO:0001558 135 0.041
positive regulation of organelle assembly GO:1902117 17 0.041
cellular ketone metabolic process GO:0042180 80 0.040
modification dependent protein catabolic process GO:0019941 209 0.040
chemotaxis GO:0006935 157 0.039
negative regulation of protein phosphorylation GO:0001933 140 0.039
ameboidal type cell migration GO:0001667 135 0.039
neuron differentiation GO:0030182 138 0.039
Fly
regulation of establishment of protein localization GO:0070201 242 0.039
Fly
maintenance of protein location GO:0045185 57 0.039
Fly
regulation of mapk cascade GO:0043408 262 0.038
cell substrate adhesion GO:0031589 132 0.038
Mouse
neuron fate commitment GO:0048663 2 0.038
cilium morphogenesis GO:0060271 75 0.038
positive regulation of cytoplasmic transport GO:1903651 82 0.037
negative regulation of growth GO:0045926 97 0.037
embryonic morphogenesis GO:0048598 85 0.037
Worm Fly
regulation of meiotic cell cycle GO:0051445 4 0.037
response to abiotic stimulus GO:0009628 336 0.036
cellular amino acid metabolic process GO:0006520 116 0.036
negative regulation of phosphate metabolic process GO:0045936 267 0.036
neuron projection morphogenesis GO:0048812 50 0.035
Fly
chromatin modification GO:0016568 298 0.035
regulation of protein kinase activity GO:0045859 289 0.035
positive regulation of cell division GO:0051781 59 0.034
endomembrane system organization GO:0010256 196 0.034
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.034
regulation of amine transport GO:0051952 5 0.034
negative regulation of growth of symbiont in host GO:0044130 1 0.034
organ maturation GO:0048799 5 0.034
modification dependent macromolecule catabolic process GO:0043632 212 0.034
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.034
calcium ion homeostasis GO:0055074 122 0.034
establishment of protein localization to membrane GO:0090150 121 0.034
regulation of cell morphogenesis GO:0022604 153 0.034
Worm Fly
meiosis i GO:0007127 4 0.034
positive regulation of cellular amine metabolic process GO:0033240 7 0.034
multivesicular body organization GO:0036257 2 0.033
cell cycle phase transition GO:0044770 173 0.033
response to ionizing radiation GO:0010212 65 0.033
negative regulation of actin filament bundle assembly GO:0032232 9 0.033
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.033
cellular protein complex assembly GO:0043623 188 0.033
cellular divalent inorganic cation homeostasis GO:0072503 128 0.033
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.033
generation of neurons GO:0048699 152 0.033
Fly
regulation of membrane potential GO:0042391 95 0.033
potassium ion transmembrane transport GO:0071805 60 0.032
leukocyte migration GO:0050900 107 0.032
neurogenesis GO:0022008 169 0.032
Fly
response to external biotic stimulus GO:0043207 261 0.032
response to other organism GO:0051707 261 0.032
protein localization to membrane GO:0072657 160 0.032
morphogenesis of embryonic epithelium GO:0016331 4 0.031
Fly
regulation of transmembrane transport GO:0034762 139 0.031
positive regulation of exocytosis GO:0045921 35 0.031
sequestering of calcium ion GO:0051208 17 0.031
neurological system process GO:0050877 163 0.031
regulation of secretion by cell GO:1903530 177 0.031
regulation of ion homeostasis GO:2000021 73 0.031
muscle organ development GO:0007517 56 0.030
salivary gland morphogenesis GO:0007435 4 0.030
rna processing GO:0006396 255 0.030
regulation of stress fiber assembly GO:0051492 32 0.029
Fly
divalent metal ion transport GO:0070838 152 0.029
regulation of embryonic development GO:0045995 20 0.029
peptidyl serine phosphorylation GO:0018105 101 0.029
regulation of jak stat cascade GO:0046425 44 0.028
anatomical structure formation involved in morphogenesis GO:0048646 284 0.028
regulation of protein localization to nucleus GO:1900180 85 0.028
negative regulation of ion transport GO:0043271 39 0.028
jak stat cascade GO:0007259 46 0.028
brain development GO:0007420 97 0.028
dephosphorylation GO:0016311 209 0.028
microtubule cytoskeleton organization GO:0000226 176 0.028
Human Fly
response to inorganic substance GO:0010035 127 0.027
cellular response to dna damage stimulus GO:0006974 379 0.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.027
lipid biosynthetic process GO:0008610 177 0.027
tube morphogenesis GO:0035239 95 0.026
Fly
nucleocytoplasmic transport GO:0006913 176 0.026
sequestering of metal ion GO:0051238 24 0.026
establishment of ribosome localization GO:0033753 4 0.026
cell morphogenesis involved in differentiation GO:0000904 144 0.026
Mouse Fly
kidney development GO:0001822 53 0.026
early endosome to late endosome transport GO:0045022 21 0.026
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.025
growth involved in symbiotic interaction GO:0044110 2 0.025
establishment of organelle localization GO:0051656 59 0.025
Fly
positive regulation of ion transport GO:0043270 87 0.025
protein maturation GO:0051604 233 0.025
locomotory behavior GO:0007626 1 0.025
response to biotic stimulus GO:0009607 276 0.025
cellular response to radiation GO:0071478 65 0.024
phosphatidylinositol metabolic process GO:0046488 53 0.024
maintenance of location in cell GO:0051651 62 0.024
Fly
amine metabolic process GO:0009308 44 0.024
multivesicular body assembly GO:0036258 1 0.024
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.024
positive regulation of endopeptidase activity GO:0010950 84 0.024
negative regulation of ion transmembrane transport GO:0034766 26 0.024
regulation of cellular amino acid metabolic process GO:0006521 6 0.024
mitochondrion organization GO:0007005 156 0.024
innate immune response GO:0045087 178 0.024
phospholipid metabolic process GO:0006644 99 0.023
negative regulation of protein metabolic process GO:0051248 391 0.023
negative chemotaxis GO:0050919 11 0.023
regulation of actin filament polymerization GO:0030833 50 0.023
cellular calcium ion homeostasis GO:0006874 117 0.023
nuclear transport GO:0051169 179 0.022
trna transport GO:0051031 1 0.022
cell activation GO:0001775 213 0.022
negative regulation of catalytic activity GO:0043086 335 0.022
cellular protein catabolic process GO:0044257 261 0.022
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.022
positive regulation of rab gtpase activity GO:0032851 39 0.022
fibroblast growth factor receptor signaling pathway GO:0008543 26 0.022
positive regulation of secretion by cell GO:1903532 108 0.022
histone modification GO:0016570 251 0.022
actin filament bundle assembly GO:0051017 54 0.021
Fly
cell junction organization GO:0034330 79 0.021
Mouse Fly
positive regulation of developmental process GO:0051094 314 0.021
mitotic cell cycle GO:0000278 326 0.021
Fly
carbohydrate derivative biosynthetic process GO:1901137 207 0.021
endosome to lysosome transport via multivesicular body sorting pathway GO:0032510 2 0.021
response to organic cyclic compound GO:0014070 204 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
growth GO:0040007 202 0.021
Fly
regulation of proteolysis GO:0030162 293 0.020
protein targeting to nucleus GO:0044744 104 0.020
mitochondrion distribution GO:0048311 3 0.020
regeneration GO:0031099 4 0.020
positive regulation of secretion GO:0051047 116 0.020
cell adhesion GO:0007155 325 0.020
response to metal ion GO:0010038 84 0.020
positive regulation of protein complex assembly GO:0031334 86 0.020
regulation of neurogenesis GO:0050767 82 0.020
Fly
regulation of actin filament bundle assembly GO:0032231 36 0.020
Fly
regulation of cell projection organization GO:0031344 107 0.020
Fly
response to nitrogen compound GO:1901698 184 0.020
positive regulation of neurotransmitter transport GO:0051590 1 0.020
protein targeting GO:0006605 187 0.020
positive regulation of cell development GO:0010720 92 0.020
negative regulation of cellular protein metabolic process GO:0032269 353 0.020
response to uv GO:0009411 73 0.020
regulation of rab gtpase activity GO:0032313 39 0.019
spermatid differentiation GO:0048515 4 0.019
protein localization to vacuole GO:0072665 11 0.019
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.019
establishment or maintenance of actin cytoskeleton polarity GO:0030950 1 0.019
biological adhesion GO:0022610 331 0.019
positive regulation of protein transport GO:0051222 135 0.019
rhythmic behavior GO:0007622 2 0.019
lipid metabolic process GO:0006629 381 0.019
immune effector process GO:0002252 159 0.019
cell junction assembly GO:0034329 67 0.019
Mouse Fly
positive regulation of proteolysis GO:0045862 142 0.019
positive regulation of cellular catabolic process GO:0031331 284 0.019
regulation of dna metabolic process GO:0051052 153 0.019
negative regulation of cell motility GO:2000146 104 0.019
potassium ion transport GO:0006813 62 0.019
regulation of actin polymerization or depolymerization GO:0008064 56 0.019
regulation of metal ion transport GO:0010959 120 0.018
neural tube formation GO:0001841 3 0.018
regulation of oocyte development GO:0060281 1 0.018
regulation of growth of symbiont in host GO:0044126 1 0.018
sensory perception of mechanical stimulus GO:0050954 37 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
negative regulation of protein modification process GO:0031400 200 0.018
oogenesis GO:0048477 2 0.018
Fly
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.018
positive regulation of programmed cell death GO:0043068 249 0.018
g1 s transition of mitotic cell cycle GO:0000082 78 0.018
rab protein signal transduction GO:0032482 4 0.017
negative regulation of immune system process GO:0002683 136 0.017
immune system development GO:0002520 195 0.017
negative regulation of locomotion GO:0040013 118 0.017
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.017
regulation of cell shape GO:0008360 48 0.017
Worm Fly
oocyte differentiation GO:0009994 2 0.017
Fly
ubiquitin dependent smad protein catabolic process GO:0030579 4 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
negative regulation of endothelial cell differentiation GO:0045602 2 0.017
regulation of camp metabolic process GO:0030814 52 0.017
negative regulation of phagocytosis GO:0050765 4 0.017
myosin filament assembly GO:0031034 2 0.017
regulation of neurotransmitter secretion GO:0046928 3 0.017
somitogenesis GO:0001756 2 0.017
cellular potassium ion transport GO:0071804 60 0.017
convergent extension GO:0060026 1 0.017
positive regulation of cell cycle GO:0045787 140 0.017
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.017
regulation of exocytosis GO:0017157 46 0.017
response to oxidative stress GO:0006979 121 0.017
regulation of wound healing GO:0061041 56 0.016
Fly
cellular response to abiotic stimulus GO:0071214 117 0.016
retrograde transport endosome to golgi GO:0042147 45 0.016
neuron apoptotic process GO:0051402 39 0.016
Mouse
regulation of ion transmembrane transport GO:0034765 132 0.016
signal release GO:0023061 70 0.016
purine nucleoside triphosphate metabolic process GO:0009144 412 0.016
negative regulation of protein ubiquitination GO:0031397 35 0.016
positive regulation of mapk cascade GO:0043410 190 0.016
regulation of homeostatic process GO:0032844 121 0.016
exosomal secretion GO:1990182 15 0.016
regulation of cell differentiation GO:0045595 393 0.016
synaptic transmission GO:0007268 61 0.016
blood vessel morphogenesis GO:0048514 162 0.016
cellular response to oxygen containing compound GO:1901701 276 0.016
lymphocyte activation GO:0046649 133 0.016
immune response GO:0006955 307 0.016
negative regulation of protein polyubiquitination GO:1902915 4 0.016
lipid modification GO:0030258 84 0.016
nucleotide catabolic process GO:0009166 408 0.016
positive regulation of endocytosis GO:0045807 42 0.016
humoral immune response GO:0006959 49 0.016
positive regulation of synaptic transmission GO:0050806 4 0.016
positive regulation of camp biosynthetic process GO:0030819 35 0.016
regulation of intracellular protein transport GO:0033157 123 0.016
negative regulation of dna metabolic process GO:0051053 57 0.016
golgi vesicle transport GO:0048193 80 0.016
axonogenesis GO:0007409 31 0.016
Fly
cytosolic calcium ion transport GO:0060401 48 0.016
positive regulation of apoptotic process GO:0043065 246 0.016
ribosomal subunit export from nucleus GO:0000054 4 0.015
regulation of cofactor metabolic process GO:0051193 3 0.015
positive regulation of cell cycle process GO:0090068 106 0.015
trabecula morphogenesis GO:0061383 2 0.015
ossification GO:0001503 121 0.015
transmembrane transport GO:0055085 399 0.015
defense response GO:0006952 315 0.015
covalent chromatin modification GO:0016569 254 0.015
multicellular organismal signaling GO:0035637 34 0.015
muscle structure development GO:0061061 98 0.015
cofactor metabolic process GO:0051186 87 0.015
filopodium assembly GO:0046847 18 0.015
neural tube closure GO:0001843 3 0.015
response to virus GO:0009615 126 0.015
regulation of protein localization to plasma membrane GO:1903076 40 0.015
epidermal cell differentiation GO:0009913 45 0.015
cellular response to fibroblast growth factor stimulus GO:0044344 39 0.015
glycerolipid biosynthetic process GO:0045017 51 0.015
blastocyst development GO:0001824 3 0.015
alcohol metabolic process GO:0006066 114 0.015
plasma membrane organization GO:0007009 115 0.015
regulation of establishment of cell polarity GO:2000114 5 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
negative regulation of phosphorylation GO:0042326 174 0.015
protein targeting to vacuole GO:0006623 8 0.015
positive regulation of cell adhesion GO:0045785 84 0.015
Mouse
cilium organization GO:0044782 68 0.015
cardiovascular system development GO:0072358 262 0.014
peptidyl tyrosine dephosphorylation GO:0035335 36 0.014
receptor mediated endocytosis GO:0006898 84 0.014
neuron development GO:0048666 113 0.014
Fly
leukocyte activation GO:0045321 164 0.014
fatty acid biosynthetic process GO:0006633 46 0.014
peripheral nervous system development GO:0007422 2 0.014
regulation of transmembrane transporter activity GO:0022898 74 0.014
regulation of neuroblast proliferation GO:1902692 3 0.014
cell growth GO:0016049 160 0.014
mapk cascade GO:0000165 288 0.014

ROCK1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.257
disease of cellular proliferation DOID:14566 174 0.257
organ system cancer DOID:0050686 164 0.257
kidney disease DOID:557 36 0.098
urinary system disease DOID:18 40 0.098
sensory system disease DOID:0050155 203 0.030
nervous system disease DOID:863 431 0.030
central nervous system disease DOID:331 186 0.026
neuropathy DOID:870 52 0.021
bone disease DOID:0080001 88 0.018
musculoskeletal system disease DOID:17 223 0.018
connective tissue disease DOID:65 109 0.018