Homo sapiens

49 known processes

RPA1

replication protein A1, 70kDa

(Aliases: HSSB,RF-A,RP-A,REPA1,MST075,RPA70)

RPA1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
dna dependent dna replication GO:0006261 44 1.000
Yeast Fly
meiosis i GO:0007127 4 1.000
Yeast
double strand break repair GO:0006302 101 1.000
base excision repair GO:0006284 21 1.000
cellular response to dna damage stimulus GO:0006974 379 1.000
nucleotide excision repair GO:0006289 31 1.000
reciprocal meiotic recombination GO:0007131 4 1.000
Yeast
purine nucleoside monophosphate catabolic process GO:0009128 158 0.999
telomere maintenance via telomerase GO:0007004 8 0.999
Yeast
dna conformation change GO:0071103 113 0.998
Yeast
regulation of double strand break repair via homologous recombination GO:0010569 11 0.996
dna repair GO:0006281 198 0.996
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.996
dna recombination GO:0006310 77 0.996
double strand break repair via homologous recombination GO:0000724 50 0.995
mismatch repair GO:0006298 15 0.995
dna strand elongation involved in dna replication GO:0006271 3 0.994
ribonucleoside monophosphate metabolic process GO:0009161 187 0.991
nucleoside triphosphate catabolic process GO:0009143 394 0.991
regulation of mitotic cell cycle GO:0007346 189 0.990
Fly
recombinational repair GO:0000725 50 0.989
reciprocal dna recombination GO:0035825 4 0.988
Yeast
leading strand elongation GO:0006272 1 0.987
dna unwinding involved in dna replication GO:0006268 2 0.986
Yeast
ribonucleoside monophosphate catabolic process GO:0009158 158 0.986
dna duplex unwinding GO:0032508 30 0.984
Yeast
nucleoside monophosphate metabolic process GO:0009123 191 0.984
non recombinational repair GO:0000726 14 0.980
atp metabolic process GO:0046034 176 0.973
purine nucleoside triphosphate catabolic process GO:0009146 392 0.968
glycosyl compound catabolic process GO:1901658 413 0.967
dna replication GO:0006260 116 0.962
nucleoside monophosphate catabolic process GO:0009125 159 0.962
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.962
purine ribonucleoside catabolic process GO:0046130 398 0.959
mitotic cell cycle GO:0000278 326 0.942
Fly
meiotic cell cycle GO:0051321 13 0.941
Yeast Mouse
cell development GO:0048468 328 0.934
Fly
regulation of dna metabolic process GO:0051052 153 0.928
regulation of response to dna damage stimulus GO:2001020 94 0.924
dna geometric change GO:0032392 32 0.924
Yeast
meiotic chromosome segregation GO:0045132 4 0.903
meiotic chromosome separation GO:0051307 3 0.897
regulation of dna recombination GO:0000018 23 0.856
dna synthesis involved in dna repair GO:0000731 6 0.854
regulation of double strand break repair GO:2000779 22 0.818
dna strand elongation GO:0022616 5 0.805
somatic hypermutation of immunoglobulin genes GO:0016446 1 0.792
nuclear division GO:0000280 128 0.780
Yeast Mouse
double strand break repair via single strand annealing GO:0045002 4 0.768
double strand break repair via nonhomologous end joining GO:0006303 10 0.767
response to radiation GO:0009314 151 0.762
neuron differentiation GO:0030182 138 0.759
Fly
nucleoside catabolic process GO:0009164 408 0.744
atp catabolic process GO:0006200 157 0.740
covalent chromatin modification GO:0016569 254 0.717
determination of adult lifespan GO:0008340 2 0.712
reproductive process GO:0022414 106 0.709
nucleoside triphosphate metabolic process GO:0009141 422 0.699
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.698
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.696
Fly
oogenesis GO:0048477 2 0.690
histone modification GO:0016570 251 0.674
dna damage checkpoint GO:0000077 68 0.669
Fly
ribonucleoside catabolic process GO:0042454 406 0.636
protein ubiquitination GO:0016567 314 0.628
Yeast
amine metabolic process GO:0009308 44 0.618
positive regulation of helicase activity GO:0051096 6 0.609
Worm
dna integrity checkpoint GO:0031570 71 0.583
Fly
mitotic dna integrity checkpoint GO:0044774 30 0.579
Fly
nervous system development GO:0007399 293 0.576
Fly
meiotic cell cycle process GO:1903046 8 0.554
Yeast
intracellular mrna localization GO:0008298 1 0.551
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.547
regulation of dna repair GO:0006282 47 0.532
purine nucleoside monophosphate metabolic process GO:0009126 186 0.514
protein dna complex subunit organization GO:0071824 80 0.512
nucleotide catabolic process GO:0009166 408 0.500
mitotic cell cycle phase transition GO:0044772 162 0.499
Fly
chromatin modification GO:0016568 298 0.487
meiotic nuclear division GO:0007126 10 0.468
Yeast Mouse
developmental process involved in reproduction GO:0003006 66 0.457
mitotic g1 s transition checkpoint GO:0044819 17 0.437
response to abiotic stimulus GO:0009628 336 0.408
ribonucleoside triphosphate metabolic process GO:0009199 412 0.401
regulation of cell cycle GO:0051726 393 0.400
Fly
negative regulation of dna metabolic process GO:0051053 57 0.375
purine ribonucleotide catabolic process GO:0009154 404 0.369
mitotic nuclear division GO:0007067 119 0.352
nucleoside phosphate catabolic process GO:1901292 412 0.352
behavior GO:0007610 112 0.350
purine nucleotide catabolic process GO:0006195 405 0.341
mitotic g1 dna damage checkpoint GO:0031571 17 0.334
chromatin organization GO:0006325 351 0.328
dna packaging GO:0006323 77 0.324
somatic diversification of immune receptors via somatic mutation GO:0002566 1 0.321
single organism reproductive process GO:0044702 98 0.308
telomere organization GO:0032200 33 0.298
cellular amino acid metabolic process GO:0006520 116 0.290
negative regulation of mitotic cell cycle GO:0045930 102 0.278
Fly
vesicle mediated transport GO:0016192 371 0.266
Worm
oocyte development GO:0048599 1 0.257
cell cycle checkpoint GO:0000075 117 0.248
Fly
organelle fission GO:0048285 149 0.246
Yeast Mouse
response to uv GO:0009411 73 0.244
interstrand cross link repair GO:0036297 3 0.240
cell division GO:0051301 168 0.236
response to light stimulus GO:0009416 87 0.235
lagging strand elongation GO:0006273 3 0.233
development of primary sexual characteristics GO:0045137 35 0.231
reproductive structure development GO:0048608 55 0.213
maintenance of dna repeat elements GO:0043570 4 0.208
purine ribonucleoside metabolic process GO:0046128 437 0.202
purine nucleoside catabolic process GO:0006152 398 0.200
mitotic recombination GO:0006312 8 0.200
Yeast
growth GO:0040007 202 0.200
chromatin remodeling GO:0006338 55 0.188
dna replication initiation GO:0006270 6 0.186
histone h3 k4 methylation GO:0051568 27 0.185
g2 dna damage checkpoint GO:0031572 26 0.182
Fly
chromosome condensation GO:0030261 15 0.176
chromatin assembly or disassembly GO:0006333 78 0.176
atp dependent chromatin remodeling GO:0043044 25 0.175
negative regulation of cell cycle process GO:0010948 121 0.175
Fly
ribonucleotide catabolic process GO:0009261 405 0.172
purine containing compound catabolic process GO:0072523 411 0.172
regulation of dna dependent dna replication GO:0090329 19 0.169
female gamete generation GO:0007292 2 0.168
microtubule based process GO:0007017 210 0.161
Fly
regulation of dna replication GO:0006275 68 0.161
viral process GO:0016032 146 0.147
negative regulation of cell cycle GO:0045786 193 0.143
Fly
regulation of cell cycle process GO:0010564 266 0.142
Fly
sister chromatid cohesion GO:0007062 24 0.138
generation of neurons GO:0048699 152 0.136
Fly
cellular component disassembly GO:0022411 92 0.131
multi organism reproductive process GO:0044703 54 0.124
histone exchange GO:0043486 3 0.123
protein dna complex assembly GO:0065004 64 0.123
nucleosome organization GO:0034728 66 0.123
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.121
cellular amine metabolic process GO:0044106 41 0.121
purine nucleoside triphosphate metabolic process GO:0009144 412 0.119
regulation of cellular response to stress GO:0080135 244 0.118
reproduction GO:0000003 63 0.116
Yeast Mouse
negative regulation of cell cycle phase transition GO:1901988 89 0.113
Fly
ribonucleoside triphosphate catabolic process GO:0009203 391 0.113
regulation of dna damage checkpoint GO:2000001 9 0.110
histone methylation GO:0016571 60 0.109
regulation of dna methylation GO:0044030 2 0.107
viral life cycle GO:0019058 132 0.103
microtubule cytoskeleton organization GO:0000226 176 0.102
Fly
protein alkylation GO:0008213 74 0.101
dna catabolic process GO:0006308 49 0.101
post embryonic development GO:0009791 2 0.100
rna dependent dna replication GO:0006278 16 0.095
Yeast
interspecies interaction between organisms GO:0044419 156 0.093
negative regulation of meiotic cell cycle GO:0051447 2 0.092
dna biosynthetic process GO:0071897 40 0.092
chromosome segregation GO:0007059 114 0.091
cell cycle phase transition GO:0044770 173 0.088
Fly
male meiosis GO:0007140 1 0.088
cell morphogenesis GO:0000902 296 0.086
Fly
regeneration GO:0031099 4 0.080
mitotic dna damage checkpoint GO:0044773 28 0.077
Fly
intrinsic apoptotic signaling pathway GO:0097193 127 0.076
regulation of cell cycle g1 s phase transition GO:1902806 42 0.073
rna transport GO:0050658 39 0.072
cellular component morphogenesis GO:0032989 314 0.070
Fly
neuron projection development GO:0031175 106 0.069
Fly
gonad development GO:0008406 34 0.068
hematopoietic stem cell differentiation GO:0060218 4 0.066
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.061
dna double strand break processing GO:0000729 10 0.058
organophosphate catabolic process GO:0046434 430 0.057
telomere maintenance via recombination GO:0000722 4 0.056
Yeast
cellular ketone metabolic process GO:0042180 80 0.056
blastocyst development GO:0001824 3 0.055
g1 s transition of mitotic cell cycle GO:0000082 78 0.055
g1 dna damage checkpoint GO:0044783 18 0.054
positive regulation of cellular amine metabolic process GO:0033240 7 0.054
sex determination GO:0007530 3 0.053
translesion synthesis GO:0019985 8 0.053
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.052
neuron projection morphogenesis GO:0048812 50 0.050
Fly
nuclear export GO:0051168 69 0.049
cytoplasmic transport GO:0016482 379 0.049
cell projection organization GO:0030030 252 0.048
Fly
resolution of meiotic recombination intermediates GO:0000712 3 0.048
multicellular organismal reproductive process GO:0048609 40 0.048
regulation of gene expression epigenetic GO:0040029 73 0.047
nuclear transport GO:0051169 179 0.045
cell projection morphogenesis GO:0048858 129 0.045
Fly
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.045
ribosome assembly GO:0042255 9 0.045
nucleosome assembly GO:0006334 50 0.045
multicellular organismal aging GO:0010259 3 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.043
regulation of mitotic cell cycle phase transition GO:1901990 118 0.043
Fly
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.043
segmentation GO:0035282 4 0.043
regulation of growth rate GO:0040009 1 0.042
cardiovascular system development GO:0072358 262 0.041
Zebrafish
response to inorganic substance GO:0010035 127 0.041
cellular response to ionizing radiation GO:0071479 32 0.040
heat acclimation GO:0010286 3 0.040
cell fate commitment GO:0045165 27 0.040
developmental maturation GO:0021700 28 0.039
somatic diversification of immunoglobulins GO:0016445 6 0.038
cellular homeostasis GO:0019725 196 0.038
regulation of binding GO:0051098 111 0.038
cell morphogenesis involved in differentiation GO:0000904 144 0.037
histone lysine methylation GO:0034968 50 0.037
anatomical structure homeostasis GO:0060249 100 0.036
cellular macromolecule catabolic process GO:0044265 380 0.036
sister chromatid segregation GO:0000819 54 0.034
regulation of cellular ketone metabolic process GO:0010565 50 0.034
dendrite morphogenesis GO:0048813 14 0.034
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.033
nitrogen compound transport GO:0071705 191 0.033
regulation of cellular amino acid metabolic process GO:0006521 6 0.033
anterior posterior axis specification GO:0009948 2 0.033
cellular response to abiotic stimulus GO:0071214 117 0.033
cellular response to oxygen containing compound GO:1901701 276 0.032
multicellular organism reproduction GO:0032504 42 0.032
regulation of cellular amine metabolic process GO:0033238 11 0.032
gene conversion GO:0035822 1 0.032
macromolecule methylation GO:0043414 97 0.032
regulation of cell cycle phase transition GO:1901987 126 0.031
Fly
receptor mediated endocytosis GO:0006898 84 0.031
Worm
positive regulation of transport GO:0051050 336 0.030
regulation of cell cycle checkpoint GO:1901976 21 0.030
rna splicing GO:0008380 131 0.030
cellular response to purine containing compound GO:0071415 3 0.030
regulation of peptidyl lysine acetylation GO:2000756 22 0.030
fertilization GO:0009566 12 0.030
immune system development GO:0002520 195 0.029
Mouse
response to heat GO:0009408 21 0.028
lipid metabolic process GO:0006629 381 0.028
regulation of helicase activity GO:0051095 8 0.028
Worm
membrane organization GO:0061024 292 0.028
dna catabolic process endonucleolytic GO:0000737 37 0.028
aging GO:0007568 66 0.028
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.027
epithelium development GO:0060429 227 0.027
cellular response to endogenous stimulus GO:0071495 336 0.027
methylation GO:0032259 106 0.027
negative regulation of cell differentiation GO:0045596 171 0.027
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.026
adaptive immune response GO:0002250 49 0.026
positive regulation of developmental process GO:0051094 314 0.026
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.025
endomembrane system organization GO:0010256 196 0.025
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.025
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.025
neuron development GO:0048666 113 0.025
Fly
regulation of intracellular transport GO:0032386 195 0.025
rna localization GO:0006403 41 0.024
detection of stimulus GO:0051606 85 0.024
negative regulation of cell death GO:0060548 345 0.024
sex differentiation GO:0007548 45 0.024
response to organic cyclic compound GO:0014070 204 0.024
embryo development GO:0009790 123 0.024
Mouse Worm
negative regulation of dna recombination GO:0045910 6 0.024
negative regulation of developmental process GO:0051093 247 0.023
engulfment of apoptotic cell GO:0043652 2 0.023
protein methylation GO:0006479 74 0.023
protein acylation GO:0043543 138 0.023
regulation of multi organism process GO:0043900 157 0.023
central nervous system development GO:0007417 123 0.023
negative regulation of apoptotic process GO:0043066 316 0.022
meiotic gene conversion GO:0006311 1 0.022
mitotic cell cycle process GO:1903047 286 0.022
Fly
rna interference GO:0016246 4 0.021
multi organism behavior GO:0051705 14 0.021
sexual reproduction GO:0019953 37 0.021
cellular response to organic cyclic compound GO:0071407 127 0.020
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.020
actin filament based movement GO:0030048 17 0.020
regulation of histone modification GO:0031056 47 0.019
neurogenesis GO:0022008 169 0.019
Fly
regulation of developmental growth GO:0048638 30 0.019
defense response to bacterium GO:0042742 63 0.019
dna damage induced protein phosphorylation GO:0006975 5 0.019
endocytosis GO:0006897 159 0.019
Worm
reproductive system development GO:0061458 56 0.018
apoptotic signaling pathway GO:0097190 268 0.018
replication fork processing GO:0031297 13 0.018
regulation of growth GO:0040008 165 0.018
mitotic centrosome separation GO:0007100 1 0.017
positive regulation of cellular component organization GO:0051130 376 0.017
regulation of histone acetylation GO:0035065 19 0.017
ribosomal small subunit export from nucleus GO:0000056 3 0.017
viral genome replication GO:0019079 50 0.017
apoptotic cell clearance GO:0043277 12 0.017
cellular modified amino acid metabolic process GO:0006575 64 0.017
regulation of meiotic cell cycle GO:0051445 4 0.017
regulation of meiosis GO:0040020 3 0.017
response to ionizing radiation GO:0010212 65 0.016
regulation of cell division GO:0051302 116 0.016
cellular response to radiation GO:0071478 65 0.016
signal transduction in response to dna damage GO:0042770 57 0.016
response to bacterium GO:0009617 144 0.016
establishment of rna localization GO:0051236 39 0.016
cell part morphogenesis GO:0032990 137 0.016
Fly
response to external biotic stimulus GO:0043207 261 0.015
nuclear dna replication GO:0033260 6 0.015
regulation of small gtpase mediated signal transduction GO:0051056 156 0.015
regulation of chromosome organization GO:0033044 103 0.015
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.015
spermatogenesis GO:0007283 22 0.015
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.015
cellular macromolecular complex assembly GO:0034622 324 0.015
nuclear migration GO:0007097 1 0.015
macromolecule glycosylation GO:0043413 63 0.015
nucleosome positioning GO:0016584 3 0.014
defense response GO:0006952 315 0.014
head development GO:0060322 108 0.014
production of molecular mediator of immune response GO:0002440 37 0.014
chemical homeostasis GO:0048878 306 0.014
negative regulation of programmed cell death GO:0043069 321 0.014
regulation of viral process GO:0050792 103 0.014
telomere maintenance GO:0000723 32 0.014
positive regulation of intracellular transport GO:0032388 104 0.014
cellular process involved in reproduction in multicellular organism GO:0022412 15 0.014
spermatid development GO:0007286 4 0.013
nucleus localization GO:0051647 1 0.013
dna ligation GO:0006266 10 0.013
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.013
negative regulation of meiosis GO:0045835 1 0.013
organelle localization GO:0051640 84 0.013
germ cell development GO:0007281 8 0.013
regulation of transcription by chromatin organization GO:0034401 1 0.013
mitotic cell cycle checkpoint GO:0007093 68 0.013
Fly
dna dependent dna replication maintenance of fidelity GO:0045005 14 0.012
secretion GO:0046903 254 0.012
multi organism cellular process GO:0044764 156 0.012
cytokinesis GO:0000910 96 0.012
positive regulation of dna metabolic process GO:0051054 73 0.012
immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 5 0.012
cation transmembrane transport GO:0098655 238 0.012
dna modification GO:0006304 27 0.012
response to gamma radiation GO:0010332 14 0.012
somatic diversification of immune receptors GO:0002200 8 0.012
nucleus organization GO:0006997 28 0.012
mrna metabolic process GO:0016071 175 0.011
regulation of mrna processing GO:0050684 48 0.011
response to oxygen containing compound GO:1901700 369 0.011
negative regulation of catalytic activity GO:0043086 335 0.011
embryo development ending in birth or egg hatching GO:0009792 34 0.011
Mouse Worm
single organism cellular localization GO:1902580 332 0.010
regulation of nucleocytoplasmic transport GO:0046822 98 0.010

RPA1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.154
disease of cellular proliferation DOID:14566 174 0.154
sensory system disease DOID:0050155 203 0.108
nervous system disease DOID:863 431 0.108
immune system disease DOID:2914 155 0.093
breast cancer DOID:1612 21 0.043
thoracic cancer DOID:5093 21 0.043
organ system cancer DOID:0050686 164 0.043
aplastic anemia DOID:12449 30 0.032
bone marrow disease DOID:4961 31 0.032
anemia DOID:2355 55 0.032
hematopoietic system disease DOID:74 100 0.032
eye and adnexa disease DOID:1492 150 0.010