Homo sapiens

124 known processes

RXRA

retinoid X receptor, alpha

(Aliases: FLJ00280,FLJ16020,NR2B1,MGC102720,FLJ00318,FLJ16733)

RXRA biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription initiation from rna polymerase ii promoter GO:0060633 3 1.000
positive regulation of interleukin 5 production GO:0032754 3 1.000
intracellular bile acid receptor signaling pathway GO:0038185 1 1.000
outflow tract septum morphogenesis GO:0003148 4 1.000
negative regulation of cholesterol storage GO:0010887 4 1.000
negative regulation of bile acid biosynthetic process GO:0070858 3 1.000
negative regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0017055 2 1.000
regulation of cellular ketone metabolic process by positive regulation of transcription from rna polymerase ii promoter GO:0072366 1 1.000
intracellular receptor signaling pathway GO:0030522 104 1.000
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.999
epithelial cell fate commitment GO:0072148 3 0.999
Human
cartilage development involved in endochondral bone morphogenesis GO:0060351 2 0.999
chondroblast differentiation GO:0060591 2 0.997
regulation of t helper cell differentiation GO:0045622 3 0.997
vitamin d receptor signaling pathway GO:0070561 4 0.997
regulation of cellular ketone metabolic process GO:0010565 50 0.996
Worm
hormone mediated signaling pathway GO:0009755 22 0.995
regulation of interleukin 5 production GO:0032674 6 0.995
lipid metabolic process GO:0006629 381 0.995
Human Worm
epithelial cell proliferation GO:0050673 128 0.994
Human
growth plate cartilage development GO:0003417 1 0.993
cellular response to hormone stimulus GO:0032870 125 0.993
Rat
cellular response to oxygen containing compound GO:1901701 276 0.992
Rat
regulation of cellular ketone metabolic process by regulation of transcription from rna polymerase ii promoter GO:0072364 3 0.992
cd4 positive alpha beta t cell differentiation involved in immune response GO:0002294 4 0.991
lipid homeostasis GO:0055088 39 0.991
Human
glandular epithelial cell differentiation GO:0002067 6 0.990
Mouse
negative regulation of epithelial cell proliferation GO:0050680 48 0.990
Human
regulation of lipid metabolic process GO:0019216 96 0.990
Human Worm
muscle cell proliferation GO:0033002 35 0.986
Mouse
regulation of cholesterol storage GO:0010885 8 0.983
exogenous drug catabolic process GO:0042738 8 0.981
negative regulation of cell proliferation GO:0008285 228 0.980
Human Rat
immune response GO:0006955 307 0.979
cellular response to endogenous stimulus GO:0071495 336 0.979
Rat
tube development GO:0035295 125 0.979
Rat
regulation of t helper 2 cell differentiation GO:0045628 1 0.978
regulation of carbohydrate metabolic process GO:0006109 54 0.974
heart development GO:0007507 95 0.974
Mouse
positive regulation of interleukin 13 production GO:0032736 4 0.971
intracellular estrogen receptor signaling pathway GO:0030520 23 0.966
response to low density lipoprotein particle GO:0055098 4 0.960
embryonic camera type eye development GO:0031076 2 0.960
regulation of body fluid levels GO:0050878 99 0.958
Human
cellular response to xenobiotic stimulus GO:0071466 29 0.948
Human
cellular carbohydrate metabolic process GO:0044262 84 0.946
negative regulation of developmental process GO:0051093 247 0.945
single organism carbohydrate metabolic process GO:0044723 193 0.942
maternal placenta development GO:0001893 5 0.938
Mouse
regulation of receptor biosynthetic process GO:0010869 15 0.938
regulation of endothelial cell migration GO:0010594 67 0.931
Human
response to oxygen containing compound GO:1901700 369 0.930
chemical homeostasis GO:0048878 306 0.929
Human
hexose metabolic process GO:0019318 55 0.928
cardiovascular system development GO:0072358 262 0.925
Human Mouse
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.925
xenobiotic metabolic process GO:0006805 28 0.923
Human
lipid biosynthetic process GO:0008610 177 0.921
cellular ketone metabolic process GO:0042180 80 0.917
Worm
response to organonitrogen compound GO:0010243 156 0.913
Rat
response to hormone GO:0009725 175 0.905
Rat
positive regulation of cd4 positive alpha beta t cell differentiation GO:0043372 2 0.903
positive regulation of apoptotic process GO:0043065 246 0.900
Rat
regulation of granulocyte differentiation GO:0030852 11 0.892
renal system development GO:0072001 63 0.890
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.889
hematopoietic or lymphoid organ development GO:0048534 186 0.888
cardiac muscle cell differentiation GO:0055007 15 0.887
Mouse
negative regulation of epithelial cell migration GO:0010633 38 0.881
Human
sterol homeostasis GO:0055092 28 0.881
response to lipopolysaccharide GO:0032496 70 0.881
cellular response to nutrient GO:0031670 12 0.877
regulation of lipid transport by regulation of transcription from rna polymerase ii promoter GO:0072367 4 0.876
xenobiotic transport GO:0042908 1 0.875
response to retinoic acid GO:0032526 33 0.875
regulation of immune response GO:0050776 201 0.874
humoral immune response GO:0006959 49 0.870
regulation of glycolytic process by regulation of transcription from rna polymerase ii promoter GO:0072361 2 0.870
innate immune response GO:0045087 178 0.869
positive regulation of apoptotic process involved in morphogenesis GO:1902339 1 0.869
cellular response to interferon gamma GO:0071346 24 0.861
circulatory system process GO:0003013 113 0.858
blood circulation GO:0008015 113 0.858
interleukin 5 production GO:0032634 6 0.856
cellular response to lipopolysaccharide GO:0071222 57 0.853
regulation of sequestering of triglyceride GO:0010889 8 0.852
enzyme linked receptor protein signaling pathway GO:0007167 303 0.846
endothelial cell proliferation GO:0001935 65 0.844
Human
urogenital system development GO:0001655 65 0.842
Mouse
cellular response to vitamin d GO:0071305 5 0.837
carbohydrate metabolic process GO:0005975 207 0.835
cellular response to peptide GO:1901653 59 0.825
Rat
covalent chromatin modification GO:0016569 254 0.822
cellular amino acid metabolic process GO:0006520 116 0.819
Human
positive regulation of cd4 positive alpha beta t cell activation GO:2000516 3 0.819
response to alcohol GO:0097305 64 0.814
Rat
regulation of epithelial cell proliferation GO:0050678 113 0.809
Human
protein processing GO:0016485 226 0.805
response to external biotic stimulus GO:0043207 261 0.800
regulation of vitamin d 24 hydroxylase activity GO:0010979 3 0.797
small molecule biosynthetic process GO:0044283 157 0.797
negative regulation of granulocyte differentiation GO:0030853 5 0.789
regulation of cell development GO:0060284 161 0.787
response to biotic stimulus GO:0009607 276 0.780
cd4 positive alpha beta t cell differentiation GO:0043367 4 0.777
neuron differentiation GO:0030182 138 0.774
Rat
neural tube formation GO:0001841 3 0.772
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.772
response to insulin GO:0032868 45 0.771
Rat
regulation of transcription involved in lymphatic endothelial cell fate commitment GO:0060849 2 0.759
Human
regulation of alpha beta t cell differentiation GO:0046637 5 0.757
type 2 immune response GO:0042092 6 0.746
positive regulation of type 2 immune response GO:0002830 2 0.745
regulation of interleukin 4 production GO:0032673 7 0.741
cellular macromolecular complex assembly GO:0034622 324 0.741
myeloid cell differentiation GO:0030099 117 0.740
developmental programmed cell death GO:0010623 3 0.733
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.729
positive regulation of epithelial cell differentiation GO:0030858 14 0.728
embryonic epithelial tube formation GO:0001838 4 0.728
response to bacterium GO:0009617 144 0.727
response to peptide hormone GO:0043434 61 0.727
Rat
negative regulation of response to interferon gamma GO:0060331 2 0.726
glycerolipid metabolic process GO:0046486 107 0.726
regulation of anatomical structure morphogenesis GO:0022603 286 0.723
Mouse
t helper 2 cell differentiation GO:0045064 1 0.721
hippocampus development GO:0021766 1 0.720
negative regulation of dna templated transcription initiation GO:2000143 3 0.717
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.714
regulation of establishment of protein localization GO:0070201 242 0.706
apoptotic process involved in morphogenesis GO:0060561 3 0.703
negative regulation of myeloid leukocyte differentiation GO:0002762 16 0.701
negative regulation of receptor biosynthetic process GO:0010871 6 0.699
immune effector process GO:0002252 159 0.698
negative regulation of immune system process GO:0002683 136 0.689
response to organic cyclic compound GO:0014070 204 0.683
Rat
toll like receptor 4 signaling pathway GO:0034142 12 0.676
positive regulation of t helper 2 cell differentiation GO:0045630 1 0.675
regulation of mapk cascade GO:0043408 262 0.672
cell development GO:0048468 328 0.670
Rat
mesonephros development GO:0001823 17 0.670
prostate gland development GO:0030850 3 0.667
Mouse
activation of immune response GO:0002253 114 0.661
positive regulation of apoptotic process involved in mammary gland involution GO:0060058 1 0.658
positive regulation of cell cycle process GO:0090068 106 0.655
tube morphogenesis GO:0035239 95 0.650
positive regulation of mapk cascade GO:0043410 190 0.645
nucleocytoplasmic transport GO:0006913 176 0.641
nervous system development GO:0007399 293 0.641
Rat
regulation of glycolytic by positive regulation of transcription from rna polymerase ii promoter GO:0072363 1 0.637
defense response GO:0006952 315 0.632
Rat
regulation of interleukin 13 production GO:0032656 7 0.631
embryonic organ development GO:0048568 36 0.628
monocarboxylic acid metabolic process GO:0032787 185 0.624
Worm
positive regulation of cell cycle GO:0045787 140 0.616
positive regulation of protein kinase b signaling GO:0051897 42 0.608
positive regulation of cytokine production GO:0001819 167 0.598
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.596
regulation of neurogenesis GO:0050767 82 0.591
regulation of protein transport GO:0051223 213 0.591
kidney development GO:0001822 53 0.590
ion homeostasis GO:0050801 230 0.586
regulation of transferase activity GO:0051338 355 0.586
Human
negative regulation of cytokine production GO:0001818 82 0.583
regulation of defense response GO:0031347 154 0.582
positive regulation of alpha beta t cell differentiation GO:0046638 4 0.582
epithelium development GO:0060429 227 0.582
Human Mouse
cellular response to external stimulus GO:0071496 111 0.582
positive regulation of cell death GO:0010942 263 0.582
Rat
monocyte differentiation GO:0030224 15 0.580
negative regulation of toll like receptor 4 signaling pathway GO:0034144 4 0.578
negative regulation of cytokine mediated signaling pathway GO:0001960 22 0.574
multicellular organismal aging GO:0010259 3 0.573
Worm
negative regulation of programmed cell death GO:0043069 321 0.572
system process GO:0003008 349 0.572
positive regulation of vitamin d 24 hydroxylase activity GO:0010980 3 0.569
tissue morphogenesis GO:0048729 96 0.568
Mouse
pattern recognition receptor signaling pathway GO:0002221 48 0.566
cardiac muscle tissue development GO:0048738 39 0.557
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.554
protein dna complex assembly GO:0065004 64 0.553
cardiac septum development GO:0003279 13 0.552
peroxisome proliferator activated receptor signaling pathway GO:0035357 7 0.547
positive regulation of innate immune response GO:0045089 79 0.547
response to estrogen GO:0043627 47 0.546
protein oligomerization GO:0051259 173 0.545
receptor biosynthetic process GO:0032800 18 0.544
hemopoiesis GO:0030097 180 0.543
generation of neurons GO:0048699 152 0.542
Rat
epithelial tube morphogenesis GO:0060562 38 0.539
regulation of glucose metabolic process GO:0010906 28 0.538
response to peptide GO:1901652 65 0.537
Rat
regulation of cytokine mediated signaling pathway GO:0001959 41 0.534
interleukin 4 production GO:0032633 7 0.534
regulation of cell cycle arrest GO:0071156 36 0.534
drug export GO:0046618 1 0.534
primary neural tube formation GO:0014020 3 0.531
negative regulation of neuron differentiation GO:0045665 21 0.529
mapk cascade GO:0000165 288 0.528
cell activation GO:0001775 213 0.528
response to cytokine GO:0034097 232 0.528
regulation of cell cycle GO:0051726 393 0.525
Human
negative regulation of locomotion GO:0040013 118 0.523
Human
bile acid metabolic process GO:0008206 14 0.523
central nervous system development GO:0007417 123 0.521
positive regulation of cell proliferation GO:0008284 301 0.517
response to vitamin d GO:0033280 10 0.515
Rat
organonitrogen compound biosynthetic process GO:1901566 200 0.513
drug transport GO:0015893 8 0.513
regulation of innate immune response GO:0045088 97 0.511
regulation of cell differentiation GO:0045595 393 0.506
digestive system development GO:0055123 75 0.502
Rat
protein targeting to nucleus GO:0044744 104 0.501
negative regulation of cellular component organization GO:0051129 235 0.501
cytokine mediated signaling pathway GO:0019221 109 0.501
lipid transport GO:0006869 90 0.500
regulation of intracellular protein transport GO:0033157 123 0.491
skin development GO:0043588 76 0.488
negative regulation of cell differentiation GO:0045596 171 0.486
drug catabolic process GO:0042737 10 0.486
wound healing GO:0042060 115 0.479
Human
response to lipid GO:0033993 206 0.479
carboxylic acid biosynthetic process GO:0046394 97 0.478
positive regulation of developmental process GO:0051094 314 0.477
cellular lipid metabolic process GO:0044255 303 0.474
Worm
mesonephric tubule development GO:0072164 14 0.473
response to acid chemical GO:0001101 66 0.473
morphogenesis of embryonic epithelium GO:0016331 4 0.467
response to other organism GO:0051707 261 0.463
regulation of protein complex assembly GO:0043254 147 0.462
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.462
positive regulation of intracellular protein transport GO:0090316 76 0.461
monosaccharide metabolic process GO:0005996 74 0.459
morphogenesis of an epithelium GO:0002009 60 0.458
Mouse
negative regulation of endothelial cell migration GO:0010596 29 0.457
Human
cytokine production GO:0001816 247 0.453
cellular response to organic cyclic compound GO:0071407 127 0.451
positive regulation of interleukin 4 production GO:0032753 3 0.447
positive regulation of cell differentiation GO:0045597 211 0.445
ossification GO:0001503 121 0.443
retinoic acid receptor signaling pathway GO:0048384 13 0.438
regulation of multi organism process GO:0043900 157 0.432
amine metabolic process GO:0009308 44 0.430
zymogen activation GO:0031638 70 0.429
response to nutrient GO:0007584 20 0.428
Rat
carbon catabolite activation of transcription from rna polymerase ii promoter GO:0000436 3 0.424
negative regulation of leukocyte differentiation GO:1902106 24 0.424
regulation of endothelial cell proliferation GO:0001936 56 0.422
Human
epidermal cell differentiation GO:0009913 45 0.421
regulation of lipid transport GO:0032368 44 0.419
regulation of cellular amino acid metabolic process GO:0006521 6 0.419
regulation of cell growth GO:0001558 135 0.413
Human
t helper cell differentiation GO:0042093 4 0.412
leukocyte differentiation GO:0002521 98 0.410
organic hydroxy compound metabolic process GO:1901615 147 0.409
monocarboxylic acid biosynthetic process GO:0072330 67 0.409
dna templated transcription initiation GO:0006352 35 0.409
carbon catabolite regulation of transcription from rna polymerase ii promoter GO:0000429 3 0.408
regulation of response to external stimulus GO:0032101 222 0.406
limbic system development GO:0021761 3 0.404
regulation of binding GO:0051098 111 0.402
connective tissue development GO:0061448 39 0.399
response to interferon gamma GO:0034341 39 0.398
kidney epithelium development GO:0072073 25 0.396
negative regulation of cell death GO:0060548 345 0.394
calcium ion homeostasis GO:0055074 122 0.394
embryonic placenta development GO:0001892 1 0.390
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.388
response to nutrient levels GO:0031667 81 0.386
Rat
ornithine metabolic process GO:0006591 3 0.385
Human
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.383
cardiac septum morphogenesis GO:0060411 9 0.383
intracellular protein transport GO:0006886 270 0.383
regulation of type 2 immune response GO:0002828 5 0.382
signal transduction by phosphorylation GO:0023014 297 0.379
translational initiation GO:0006413 48 0.379
Mouse
cellular glucan metabolic process GO:0006073 22 0.374
tumor necrosis factor production GO:0032640 43 0.374
cellular response to molecule of bacterial origin GO:0071219 62 0.371
phospholipid metabolic process GO:0006644 99 0.371
cardiac chamber development GO:0003205 30 0.370
Mouse
cellular response to nitrogen compound GO:1901699 144 0.368
Rat
positive regulation of epidermal cell differentiation GO:0045606 8 0.367
regulation of alpha beta t cell activation GO:0046634 13 0.366
carbon catabolite activation of transcription GO:0045991 3 0.366
regulation of proteolysis GO:0030162 293 0.361
positive regulation of programmed cell death GO:0043068 249 0.359
Rat
regulation of immune effector process GO:0002697 91 0.357
regulation of neuron differentiation GO:0045664 70 0.357
digestive tract development GO:0048565 75 0.355
Rat
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.354
cell cycle phase transition GO:0044770 173 0.352
regulation of glycolytic process GO:0006110 10 0.351
apoptotic signaling pathway GO:0097190 268 0.350
polysaccharide metabolic process GO:0005976 33 0.350
regulation of epithelial cell migration GO:0010632 93 0.346
Human
cellular response to biotic stimulus GO:0071216 71 0.343
negative regulation of protein complex assembly GO:0031333 43 0.341
regulation of myeloid leukocyte differentiation GO:0002761 39 0.340
positive regulation of peptidase activity GO:0010952 88 0.338
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.337
cellular response to peptide hormone stimulus GO:0071375 56 0.332
Rat
regulation of cell activation GO:0050865 125 0.332
negative regulation of keratinocyte proliferation GO:0010839 5 0.331
embryonic morphogenesis GO:0048598 85 0.331
regulation of synaptic plasticity GO:0048167 3 0.327
lipid localization GO:0010876 106 0.326
Worm
innate immune response activating signal transduction GO:0002758 48 0.324
hindbrain development GO:0030902 3 0.321
glucose metabolic process GO:0006006 45 0.320
positive regulation of binding GO:0051099 45 0.318
immune response regulating signaling pathway GO:0002764 97 0.315
apoptotic cell clearance GO:0043277 12 0.313
anatomical structure formation involved in morphogenesis GO:0048646 284 0.313
digestion GO:0007586 22 0.309
cellular response to lipid GO:0071396 127 0.309
positive regulation of leukocyte activation GO:0002696 80 0.307
energy reserve metabolic process GO:0006112 22 0.306
positive regulation of fatty acid metabolic process GO:0045923 11 0.303
neural tube closure GO:0001843 3 0.302
positive regulation of immune system process GO:0002684 283 0.302
lymphatic endothelial cell fate commitment GO:0060838 2 0.300
Human
protein maturation GO:0051604 233 0.299
negative regulation of cartilage development GO:0061037 5 0.297
oxidation reduction process GO:0055114 396 0.295
regulation of dna metabolic process GO:0051052 153 0.295
regulation of transcription by galactose GO:0000409 1 0.294
alpha beta t cell differentiation GO:0046632 7 0.294
metal ion homeostasis GO:0055065 169 0.292
single organism reproductive process GO:0044702 98 0.291
Mouse Rat
regulation of toll like receptor 4 signaling pathway GO:0034143 9 0.291
regulation of rna polymerase ii transcriptional preinitiation complex assembly GO:0045898 3 0.290
single organism cellular localization GO:1902580 332 0.289
regulation of response to biotic stimulus GO:0002831 55 0.288
modification of morphology or physiology of other organism GO:0035821 43 0.287
skeletal system development GO:0001501 79 0.286
regulation of lipid biosynthetic process GO:0046890 47 0.285
positive regulation of ossification GO:0045778 32 0.285
negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556 20 0.284
cell cycle arrest GO:0007050 71 0.282
negative regulation of apoptotic process GO:0043066 316 0.280
ureteric bud development GO:0001657 13 0.280
bile acid signaling pathway GO:0038183 3 0.278
regulation of myeloid cell differentiation GO:0045637 81 0.278
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.276
negative regulation of protein phosphorylation GO:0001933 140 0.275
Human
ensheathment of neurons GO:0007272 6 0.271
Rat
regeneration GO:0031099 4 0.269
Rat
regulation of generation of precursor metabolites and energy GO:0043467 27 0.269
positive regulation of t helper cell differentiation GO:0045624 2 0.268
calcium ion transport GO:0006816 147 0.266
neurogenesis GO:0022008 169 0.266
Rat
regulation of erk1 and erk2 cascade GO:0070372 99 0.265
negative regulation of sequestering of triglyceride GO:0010891 5 0.265
alcohol metabolic process GO:0006066 114 0.262
muscle tissue development GO:0060537 62 0.261
Mouse
cellular polysaccharide metabolic process GO:0044264 27 0.260
cardiac chamber morphogenesis GO:0003206 26 0.259
Mouse
cytoplasmic transport GO:0016482 379 0.258
immune system development GO:0002520 195 0.258
response to steroid hormone GO:0048545 80 0.258
Rat
chromatin organization GO:0006325 351 0.256
fat soluble vitamin metabolic process GO:0006775 19 0.255
regulation of cell adhesion GO:0030155 166 0.253
interferon gamma production GO:0032609 39 0.252
cellular response to extracellular stimulus GO:0031668 72 0.251
cardiocyte differentiation GO:0035051 23 0.250
Mouse
epithelium migration GO:0090132 119 0.249
Human
ventricular cardiac muscle cell differentiation GO:0055012 1 0.247
Mouse
protein localization to organelle GO:0033365 280 0.246
myeloid leukocyte differentiation GO:0002573 60 0.245
tube closure GO:0060606 3 0.244
growth GO:0040007 202 0.243
Human Mouse
regulation of homeostatic process GO:0032844 121 0.243
chromatin modification GO:0016568 298 0.242
regulation of intracellular transport GO:0032386 195 0.241
negative regulation of phosphorylation GO:0042326 174 0.240
Human
activation of cysteine type endopeptidase activity GO:0097202 57 0.240
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.240
regulation of apoptotic process involved in morphogenesis GO:1902337 1 0.240
generation of precursor metabolites and energy GO:0006091 68 0.240
gland development GO:0048732 48 0.239
Mouse Rat
response to light stimulus GO:0009416 87 0.238
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.238
positive regulation of protein transport GO:0051222 135 0.236
negative regulation of cell adhesion GO:0007162 64 0.236
muscle cell differentiation GO:0042692 63 0.234
Mouse
gland morphogenesis GO:0022612 8 0.233
Mouse
single organism carbohydrate catabolic process GO:0044724 33 0.233
negative regulation of lipid metabolic process GO:0045833 38 0.231
regulation of intracellular estrogen receptor signaling pathway GO:0033146 13 0.230
alpha beta t cell activation involved in immune response GO:0002287 5 0.230
negative regulation of myeloid cell differentiation GO:0045638 42 0.230
reproductive process GO:0022414 106 0.227
Mouse Rat
endocytosis GO:0006897 159 0.226
Worm
positive regulation of cellular amine metabolic process GO:0033240 7 0.225
positive regulation of transport GO:0051050 336 0.225
regulation of nervous system development GO:0051960 88 0.222
Rat
regulation of nucleocytoplasmic transport GO:0046822 98 0.220
response to abiotic stimulus GO:0009628 336 0.220
positive regulation of protein import into nucleus GO:0042307 46 0.219
steroid metabolic process GO:0008202 94 0.217
receptor metabolic process GO:0043112 81 0.215
cell growth GO:0016049 160 0.211
Human
mesonephric epithelium development GO:0072163 14 0.211
immune response activating signal transduction GO:0002757 90 0.209
columnar cuboidal epithelial cell development GO:0002066 5 0.207
response to radiation GO:0009314 151 0.206
regulation of transcription initiation from rna polymerase ii promoter GO:0060260 8 0.205
regulation of cytokine production GO:0001817 232 0.205
cellular calcium ion homeostasis GO:0006874 117 0.203
activation of innate immune response GO:0002218 55 0.203
positive regulation of leukocyte differentiation GO:1902107 37 0.202
regulation of ion transport GO:0043269 189 0.201
negative regulation of fibroblast proliferation GO:0048147 12 0.201
circulatory system development GO:0072359 262 0.201
Human Mouse
aging GO:0007568 66 0.200
Rat Worm
regulation of gluconeogenesis by regulation of transcription from rna polymerase ii promoter GO:0035947 1 0.197
lung epithelial cell differentiation GO:0060487 1 0.194
cation transport GO:0006812 331 0.194
protein dna complex subunit organization GO:0071824 80 0.192
cellular response to insulin stimulus GO:0032869 41 0.192
Rat
metal ion transport GO:0030001 272 0.192
negative regulation of phosphate metabolic process GO:0045936 267 0.188
Human
positive regulation of proteolysis GO:0045862 142 0.185
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.184
response to molecule of bacterial origin GO:0002237 82 0.183
response to extracellular stimulus GO:0009991 85 0.182
Rat
bile acid biosynthetic process GO:0006699 10 0.180
negative regulation of lipid storage GO:0010888 11 0.179
positive regulation of cell cycle arrest GO:0071158 23 0.178
trachea development GO:0060438 1 0.176
triglyceride metabolic process GO:0006641 23 0.170
mammary gland morphogenesis GO:0060443 2 0.169
production of molecular mediator of immune response GO:0002440 37 0.168
nuclear import GO:0051170 106 0.168
positive regulation of cell development GO:0010720 92 0.166
negative regulation of response to cytokine stimulus GO:0060761 25 0.166
positive regulation of epithelial cell proliferation GO:0050679 65 0.164
negative regulation of macrophage activation GO:0043031 1 0.164
defense response to bacterium GO:0042742 63 0.164
interferon gamma mediated signaling pathway GO:0060333 7 0.163
regulation of keratinocyte proliferation GO:0010837 11 0.163
insulin receptor signaling pathway GO:0008286 23 0.163
response to wounding GO:0009611 168 0.162
Human Rat
cellular divalent inorganic cation homeostasis GO:0072503 128 0.162
keratinocyte proliferation GO:0043616 17 0.160
organic acid biosynthetic process GO:0016053 97 0.160
regulation of translational initiation GO:0006446 24 0.160
Mouse
regulation of protein serine threonine kinase activity GO:0071900 179 0.159
Human
regulation of carbohydrate catabolic process GO:0043470 11 0.158
alpha beta t cell differentiation involved in immune response GO:0002293 5 0.157
secretion GO:0046903 254 0.157
regulation of interferon gamma production GO:0032649 36 0.155
intestinal absorption GO:0050892 4 0.154
mammary gland involution GO:0060056 1 0.154
mitotic cell cycle process GO:1903047 286 0.154
epithelial cell differentiation GO:0030855 141 0.153
Human Mouse
neurological system process GO:0050877 163 0.150
regulation of endopeptidase activity GO:0052548 170 0.149
response to vitamin GO:0033273 13 0.148
Rat
glycerolipid biosynthetic process GO:0045017 51 0.147
lactation GO:0007595 3 0.146
positive regulation of cell activation GO:0050867 81 0.146
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.146
positive regulation of immune response GO:0050778 159 0.145
t cell activation GO:0042110 99 0.144
neutral lipid metabolic process GO:0006638 27 0.143
organic hydroxy compound biosynthetic process GO:1901617 71 0.143
macrophage derived foam cell differentiation GO:0010742 15 0.143
negative regulation of cellular protein metabolic process GO:0032269 353 0.142
Human
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.142
response to estradiol GO:0032355 23 0.142
regulation of cellular component biogenesis GO:0044087 281 0.141
vitamin d metabolic process GO:0042359 10 0.140
regulation of cell cycle process GO:0010564 266 0.140
regulation of antimicrobial humoral response GO:0002759 1 0.139
peptide metabolic process GO:0006518 51 0.138
regulation of cartilage development GO:0061035 12 0.138
cellular response to estrogen stimulus GO:0071391 16 0.135
cellular response to cytokine stimulus GO:0071345 181 0.134
positive regulation of endopeptidase activity GO:0010950 84 0.134
negative regulation of macrophage derived foam cell differentiation GO:0010745 7 0.133
cellular amide metabolic process GO:0043603 69 0.132
translation GO:0006412 132 0.131
Mouse
embryo development ending in birth or egg hatching GO:0009792 34 0.131
Mouse Worm
regulation of cell migration GO:0030334 289 0.131
Human
negative regulation of multicellular organismal process GO:0051241 317 0.131
Human
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.130
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.130
regulation of protein localization GO:0032880 296 0.130

RXRA disease predictions

Disease DO term ID Size Probability Func Analog Org
neuromuscular disease DOID:440 38 0.799
nervous system disease DOID:863 431 0.799
neuropathy DOID:870 52 0.799
musculoskeletal system disease DOID:17 223 0.598
connective tissue disease DOID:65 109 0.598
bone disease DOID:0080001 88 0.246