Homo sapiens

30 known processes

SH2D4A

SH2 domain containing 4A

(Aliases: FLJ20967,SH2A)

SH2D4A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amine metabolic process GO:0044106 41 0.935
positive regulation of cellular amine metabolic process GO:0033240 7 0.907
peptidyl serine phosphorylation GO:0018105 101 0.899
peptidyl serine modification GO:0018209 106 0.854
myeloid cell differentiation GO:0030099 117 0.842
peptidyl tyrosine phosphorylation GO:0018108 170 0.820
regulation of actin filament polymerization GO:0030833 50 0.819
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.804
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.761
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.757
regulation of myeloid cell differentiation GO:0045637 81 0.757
regulation of protein complex assembly GO:0043254 147 0.751
protein import GO:0017038 130 0.749
leukocyte apoptotic process GO:0071887 31 0.723
regulation of cellular amino acid metabolic process GO:0006521 6 0.718
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.693
peptidyl tyrosine modification GO:0018212 170 0.678
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.669
positive regulation of intracellular protein transport GO:0090316 76 0.653
regulation of cellular ketone metabolic process GO:0010565 50 0.630
regulation of protein targeting GO:1903533 91 0.625
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.619
regulation of transcription factor import into nucleus GO:0042990 39 0.617
positive regulation of protein kinase b signaling GO:0051897 42 0.598
cellular ketone metabolic process GO:0042180 80 0.584
positive regulation of cytoplasmic transport GO:1903651 82 0.583
regulation of protein polymerization GO:0032271 63 0.583
regulation of myeloid leukocyte differentiation GO:0002761 39 0.564
regulation of peptidyl serine phosphorylation GO:0033135 50 0.522
regulation of cellular amine metabolic process GO:0033238 11 0.502
establishment of protein localization to organelle GO:0072594 172 0.500
regulation of leukocyte differentiation GO:1902105 61 0.491
cellular protein complex assembly GO:0043623 188 0.482
cellular macromolecular complex assembly GO:0034622 324 0.473
negative regulation of cell death GO:0060548 345 0.465
positive regulation of leukocyte differentiation GO:1902107 37 0.463
regulation of actin filament length GO:0030832 56 0.462
positive regulation of transcription factor import into nucleus GO:0042993 25 0.457
protein polymerization GO:0051258 71 0.456
neuromuscular junction development GO:0007528 3 0.453
regulation of cell differentiation GO:0045595 393 0.452
positive regulation of protein transport GO:0051222 135 0.449
protein import into nucleus GO:0006606 104 0.442
myeloid leukocyte differentiation GO:0002573 60 0.434
positive regulation of cellular component organization GO:0051130 376 0.432
negative regulation of leukocyte apoptotic process GO:2000107 16 0.430
phosphatidylinositol 3 kinase signaling GO:0014065 48 0.430
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.429
phosphatidylinositol mediated signaling GO:0048015 55 0.427
regulation of leukocyte apoptotic process GO:2000106 25 0.426
nuclear import GO:0051170 106 0.422
protein kinase b signaling GO:0043491 69 0.412
nuclear transport GO:0051169 179 0.412
positive regulation of protein phosphorylation GO:0001934 313 0.412
regulation of actin polymerization or depolymerization GO:0008064 56 0.408
regulation of cellular component biogenesis GO:0044087 281 0.402
transcription factor import into nucleus GO:0042991 40 0.398
positive regulation of protein localization to nucleus GO:1900182 48 0.394
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.390
regulation of cellular component size GO:0032535 82 0.385
ras protein signal transduction GO:0007265 73 0.375
regulation of nucleocytoplasmic transport GO:0046822 98 0.370
positive regulation of myeloid cell differentiation GO:0045639 39 0.369
protein localization to nucleus GO:0034504 136 0.351
actin filament polymerization GO:0030041 45 0.322
protein localization to organelle GO:0033365 280 0.321
regulation of protein localization to nucleus GO:1900180 85 0.317
regulation of granulocyte differentiation GO:0030852 11 0.311
actin polymerization or depolymerization GO:0008154 56 0.307
positive regulation of intracellular transport GO:0032388 104 0.306
protein targeting GO:0006605 187 0.305
response to cytokine GO:0034097 232 0.286
regulation of anatomical structure size GO:0090066 101 0.257
nucleocytoplasmic transport GO:0006913 176 0.255
cellular response to cytokine stimulus GO:0071345 181 0.254
actin filament based process GO:0030029 224 0.251
regulation of cytoplasmic transport GO:1903649 149 0.250
regulation of protein import into nucleus GO:0042306 78 0.248
single organism nuclear import GO:1902593 104 0.245
podosome assembly GO:0071800 6 0.242
regulation of protein kinase b signaling GO:0051896 61 0.239
positive regulation of phosphorylation GO:0042327 394 0.238
actin filament organization GO:0007015 128 0.218
negative regulation of apoptotic process GO:0043066 316 0.217
inositol lipid mediated signaling GO:0048017 55 0.215
intracellular protein transport GO:0006886 270 0.208
small gtpase mediated signal transduction GO:0007264 78 0.202
regulation of protein transport GO:0051223 213 0.202
regulation of intracellular transport GO:0032386 195 0.194
regulation of protein localization GO:0032880 296 0.190
single organism cellular localization GO:1902580 332 0.186
regulation of actin filament based process GO:0032970 141 0.177
positive regulation of cell differentiation GO:0045597 211 0.175
positive regulation of cellular component biogenesis GO:0044089 158 0.167
hematopoietic or lymphoid organ development GO:0048534 186 0.165
positive regulation of protein import into nucleus GO:0042307 46 0.162
regulation of cytoskeleton organization GO:0051493 177 0.152
hemopoiesis GO:0030097 180 0.149
immune system development GO:0002520 195 0.149
cellular amino acid metabolic process GO:0006520 116 0.144
protein targeting to nucleus GO:0044744 104 0.138
cytoplasmic transport GO:0016482 379 0.137
cell type specific apoptotic process GO:0097285 125 0.130
negative regulation of programmed cell death GO:0043069 321 0.129
regulation of establishment of protein localization GO:0070201 242 0.125
positive regulation of developmental process GO:0051094 314 0.117
positive regulation of immune system process GO:0002684 283 0.116
actin cytoskeleton organization GO:0030036 207 0.115
regulation of actin cytoskeleton organization GO:0032956 116 0.106
positive regulation of jak stat cascade GO:0046427 35 0.102
positive regulation of transport GO:0051050 336 0.099
erythrocyte homeostasis GO:0034101 31 0.098
regulation of intracellular protein transport GO:0033157 123 0.087
regulation of jak stat cascade GO:0046425 44 0.084
granulocyte differentiation GO:0030851 16 0.081
positive regulation of protein complex assembly GO:0031334 86 0.077
positive regulation of macrophage differentiation GO:0045651 7 0.074
rac protein signal transduction GO:0016601 12 0.073
cell adhesion GO:0007155 325 0.069
organelle assembly GO:0070925 176 0.066
leukocyte differentiation GO:0002521 98 0.065
positive regulation of cell proliferation GO:0008284 301 0.065
jak stat cascade GO:0007259 46 0.064
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.055
neuron projection development GO:0031175 106 0.054
regulation of growth GO:0040008 165 0.054
post embryonic development GO:0009791 2 0.053
nervous system development GO:0007399 293 0.053
dephosphorylation GO:0016311 209 0.052
single organism membrane organization GO:0044802 268 0.049
positive regulation of granulocyte differentiation GO:0030854 7 0.046
regulation of cell cycle GO:0051726 393 0.046
cell projection organization GO:0030030 252 0.045
synaptic vesicle endocytosis GO:0048488 2 0.044
cell morphogenesis GO:0000902 296 0.043
plasma membrane organization GO:0007009 115 0.040
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.039
regulation of macrophage differentiation GO:0045649 9 0.039
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
negative regulation of phosphorus metabolic process GO:0010563 267 0.037
growth GO:0040007 202 0.035
mitotic cell cycle GO:0000278 326 0.033
response to hormone GO:0009725 175 0.031
neuron development GO:0048666 113 0.030
lipid metabolic process GO:0006629 381 0.030
neuron projection morphogenesis GO:0048812 50 0.030
amine metabolic process GO:0009308 44 0.030
tyrosine phosphorylation of stat protein GO:0007260 33 0.030
multicellular organismal aging GO:0010259 3 0.029
purine nucleoside catabolic process GO:0006152 398 0.029
mapk cascade GO:0000165 288 0.028
regulation of cellular response to stress GO:0080135 244 0.028
positive regulation of nervous system development GO:0051962 54 0.028
positive regulation of gtpase activity GO:0043547 166 0.027
negative regulation of catalytic activity GO:0043086 335 0.026
oogenesis GO:0048477 2 0.026
regulation of purine nucleotide metabolic process GO:1900542 264 0.026
rna processing GO:0006396 255 0.026
negative regulation of cell proliferation GO:0008285 228 0.025
generation of neurons GO:0048699 152 0.025
regulation of response to external stimulus GO:0032101 222 0.025
neurogenesis GO:0022008 169 0.024
positive regulation of growth GO:0045927 58 0.024
regeneration GO:0031099 4 0.024
regulation of cell cycle process GO:0010564 266 0.024
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.023
cellular macromolecule catabolic process GO:0044265 380 0.023
purine ribonucleotide catabolic process GO:0009154 404 0.023
gtp catabolic process GO:0006184 237 0.023
female gamete generation GO:0007292 2 0.023
neuron differentiation GO:0030182 138 0.023
regulation of developmental growth GO:0048638 30 0.023
cell development GO:0048468 328 0.023
single organism cell adhesion GO:0098602 179 0.022
nucleoside catabolic process GO:0009164 408 0.022
rho protein signal transduction GO:0007266 26 0.022
organic acid biosynthetic process GO:0016053 97 0.022
determination of adult lifespan GO:0008340 2 0.022
organelle localization GO:0051640 84 0.022
locomotory behavior GO:0007626 1 0.022
adult locomotory behavior GO:0008344 1 0.022
carbohydrate metabolic process GO:0005975 207 0.022
chemotaxis GO:0006935 157 0.022
guanosine containing compound catabolic process GO:1901069 239 0.021
negative regulation of cellular protein metabolic process GO:0032269 353 0.021
cell part morphogenesis GO:0032990 137 0.020
negative regulation of phosphorylation GO:0042326 174 0.020
regulation of cellular component movement GO:0051270 334 0.020
cellular response to oxygen containing compound GO:1901701 276 0.020
cell chemotaxis GO:0060326 112 0.020
membrane organization GO:0061024 292 0.019
modification dependent protein catabolic process GO:0019941 209 0.019
cell division GO:0051301 168 0.018
ribonucleoside catabolic process GO:0042454 406 0.018
cell cell signaling GO:0007267 155 0.018
spermatid differentiation GO:0048515 4 0.018
cellular lipid metabolic process GO:0044255 303 0.018
compound eye development GO:0048749 1 0.017
carboxylic acid biosynthetic process GO:0046394 97 0.017
protein autophosphorylation GO:0046777 123 0.017
myeloid cell homeostasis GO:0002262 34 0.017
protein oligomerization GO:0051259 173 0.017
negative regulation of intracellular signal transduction GO:1902532 183 0.017
ribonucleoside triphosphate catabolic process GO:0009203 391 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.016
organonitrogen compound biosynthetic process GO:1901566 200 0.016
protein dephosphorylation GO:0006470 81 0.016
oxidation reduction process GO:0055114 396 0.016
neurological system process GO:0050877 163 0.016
regulation of protein kinase activity GO:0045859 289 0.016
negative regulation of cell cycle GO:0045786 193 0.016
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.016
response to radiation GO:0009314 151 0.016
protein maturation GO:0051604 233 0.015
metal ion homeostasis GO:0055065 169 0.015
mitotic cell cycle process GO:1903047 286 0.015
developmental growth GO:0048589 48 0.015
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.015
cell substrate adhesion GO:0031589 132 0.015
regulation of meiotic cell cycle GO:0051445 4 0.015
negative regulation of cellular component organization GO:0051129 235 0.015
leukocyte migration GO:0050900 107 0.015
mitochondrion organization GO:0007005 156 0.015
epithelial cell proliferation GO:0050673 128 0.015
spermatid development GO:0007286 4 0.015
nucleotide catabolic process GO:0009166 408 0.015
cellular component disassembly GO:0022411 92 0.015
regulation of nucleoside metabolic process GO:0009118 209 0.015
cell cycle phase transition GO:0044770 173 0.015
small molecule biosynthetic process GO:0044283 157 0.014
cellular metal ion homeostasis GO:0006875 146 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
epithelium development GO:0060429 227 0.014
regulation of small gtpase mediated signal transduction GO:0051056 156 0.014
positive regulation of organelle organization GO:0010638 195 0.014
behavior GO:0007610 112 0.014
cell growth GO:0016049 160 0.014
endomembrane system organization GO:0010256 196 0.014
negative regulation of cell cycle process GO:0010948 121 0.014
transmembrane transport GO:0055085 399 0.014
positive regulation of ras gtpase activity GO:0032320 117 0.014
protein catabolic process GO:0030163 325 0.014
purine ribonucleoside metabolic process GO:0046128 437 0.013
mrna metabolic process GO:0016071 175 0.013
segmentation GO:0035282 4 0.013
reactive oxygen species metabolic process GO:0072593 75 0.013
regulation of behavior GO:0050795 82 0.013
regulation of cell adhesion GO:0030155 166 0.013
cellular response to endogenous stimulus GO:0071495 336 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
negative regulation of protein modification process GO:0031400 200 0.013
positive regulation of nucleotide metabolic process GO:0045981 230 0.013
ion homeostasis GO:0050801 230 0.013
memory GO:0007613 3 0.013
cellular response to dna damage stimulus GO:0006974 379 0.013
regulation of cell projection organization GO:0031344 107 0.013
regulation of mitotic cell cycle GO:0007346 189 0.013
nucleoside triphosphate metabolic process GO:0009141 422 0.013
regulation of mitotic cell cycle phase transition GO:1901990 118 0.012
regulation of nervous system development GO:0051960 88 0.012
ubiquitin dependent protein catabolic process GO:0006511 206 0.012
endosomal transport GO:0016197 129 0.012
mitotic cell cycle phase transition GO:0044772 162 0.012
response to light stimulus GO:0009416 87 0.012
chemical homeostasis GO:0048878 306 0.012
secretion GO:0046903 254 0.012
monocarboxylic acid metabolic process GO:0032787 185 0.012
regulation of gtpase activity GO:0043087 180 0.012
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.012
negative regulation of transferase activity GO:0051348 124 0.012
chromosome segregation GO:0007059 114 0.012
homeostasis of number of cells GO:0048872 40 0.012
ameboidal type cell migration GO:0001667 135 0.012
regulation of cell cycle phase transition GO:1901987 126 0.012
positive regulation of cell death GO:0010942 263 0.012
regulation of protein catabolic process GO:0042176 155 0.012
multi organism cellular process GO:0044764 156 0.011
monovalent inorganic cation transport GO:0015672 128 0.011
jnk cascade GO:0007254 80 0.011
response to lipid GO:0033993 206 0.011
sensory perception GO:0007600 103 0.011
purine nucleoside triphosphate metabolic process GO:0009144 412 0.011
positive regulation of gtp catabolic process GO:0033126 166 0.011
positive regulation of apoptotic process GO:0043065 246 0.011
epithelial cell migration GO:0010631 119 0.011
purine nucleoside triphosphate catabolic process GO:0009146 392 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
positive regulation of response to external stimulus GO:0032103 88 0.011
positive regulation of synapse assembly GO:0051965 5 0.011
g1 s transition of mitotic cell cycle GO:0000082 78 0.011
associative learning GO:0008306 1 0.011
organic hydroxy compound metabolic process GO:1901615 147 0.011
regulation of cell growth GO:0001558 135 0.011
proteasomal protein catabolic process GO:0010498 176 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
positive regulation of developmental growth GO:0048639 16 0.011
negative regulation of catabolic process GO:0009895 104 0.011
microtubule based process GO:0007017 210 0.011
macrophage differentiation GO:0030225 11 0.011
regulation of meiosis GO:0040020 3 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
regulation of epithelial cell proliferation GO:0050678 113 0.011
negative regulation of organelle organization GO:0010639 126 0.011
leukocyte activation GO:0045321 164 0.010
regulation of dephosphorylation GO:0035303 96 0.010
cell junction organization GO:0034330 79 0.010
positive regulation of nucleoside metabolic process GO:0045979 186 0.010
myeloid leukocyte migration GO:0097529 62 0.010
regulation of cell division GO:0051302 116 0.010
positive regulation of catabolic process GO:0009896 310 0.010
sequestering of metal ion GO:0051238 24 0.010
biological adhesion GO:0022610 331 0.010
cofactor metabolic process GO:0051186 87 0.010
anterior posterior axis specification embryo GO:0008595 2 0.010
cellular response to oxidative stress GO:0034599 85 0.010
glycerolipid metabolic process GO:0046486 107 0.010
meiotic chromosome segregation GO:0045132 4 0.010
negative regulation of cell growth GO:0030308 83 0.010
nucleus localization GO:0051647 1 0.010
response to biotic stimulus GO:0009607 276 0.010
hindbrain development GO:0030902 3 0.010

SH2D4A disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.020
sensory system disease DOID:0050155 203 0.017
nervous system disease DOID:863 431 0.017
central nervous system disease DOID:331 186 0.016
musculoskeletal system disease DOID:17 223 0.015
muscular disease DOID:0080000 114 0.015
muscle tissue disease DOID:66 113 0.015
disease of cellular proliferation DOID:14566 174 0.012
eye and adnexa disease DOID:1492 150 0.011
eye disease DOID:5614 149 0.011
myopathy DOID:423 104 0.010
muscular dystrophy DOID:9884 51 0.010
cancer DOID:162 167 0.010
organ system cancer DOID:0050686 164 0.010
inherited metabolic disorder DOID:655 242 0.010