Homo sapiens

9 known processes

SHMT2

serine hydroxymethyltransferase 2 (mitochondrial)

(Aliases: SHMT,GLYA)

SHMT2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular amino acid metabolic process GO:0006520 116 0.930
Human
small molecule biosynthetic process GO:0044283 157 0.773
coenzyme metabolic process GO:0006732 65 0.716
Human
trna aminoacylation for protein translation GO:0006418 8 0.696
amino acid activation GO:0043038 12 0.657
post embryonic development GO:0009791 2 0.560
multicellular organismal aging GO:0010259 3 0.502
trna aminoacylation GO:0043039 12 0.476
cellular response to oxidative stress GO:0034599 85 0.445
organonitrogen compound biosynthetic process GO:1901566 200 0.424
Human
monocarboxylic acid metabolic process GO:0032787 185 0.386
response to organonitrogen compound GO:0010243 156 0.383
cellular macromolecule catabolic process GO:0044265 380 0.349
nucleotide biosynthetic process GO:0009165 109 0.301
organophosphate biosynthetic process GO:0090407 163 0.284
alpha amino acid metabolic process GO:1901605 72 0.270
Human
purine containing compound biosynthetic process GO:0072522 88 0.244
Human
chemical homeostasis GO:0048878 306 0.216
regulation of translation GO:0006417 89 0.216
glycine metabolic process GO:0006544 4 0.188
response to nitrogen compound GO:1901698 184 0.185
regulation of mitotic cell cycle GO:0007346 189 0.165
oxidation reduction process GO:0055114 396 0.159
female gamete generation GO:0007292 2 0.149
nucleoside phosphate biosynthetic process GO:1901293 109 0.147
determination of adult lifespan GO:0008340 2 0.129
response to hormone GO:0009725 175 0.127
purine nucleoside triphosphate metabolic process GO:0009144 412 0.122
serine family amino acid metabolic process GO:0009069 12 0.121
Human
regulation of cell cycle GO:0051726 393 0.116
response to oxygen containing compound GO:1901700 369 0.116
mitochondrion organization GO:0007005 156 0.112
organic acid biosynthetic process GO:0016053 97 0.097
cofactor metabolic process GO:0051186 87 0.096
Human
embryo development GO:0009790 123 0.096
oogenesis GO:0048477 2 0.096
positive regulation of mitotic cell cycle GO:0045931 60 0.095
purine ribonucleotide biosynthetic process GO:0009152 79 0.093
regulation of dna metabolic process GO:0051052 153 0.091
negative regulation of cellular component organization GO:0051129 235 0.090
cellular response to oxygen containing compound GO:1901701 276 0.089
cellular homeostasis GO:0019725 196 0.088
negative regulation of developmental process GO:0051093 247 0.087
dicarboxylic acid metabolic process GO:0043648 29 0.084
Human
negative regulation of protein metabolic process GO:0051248 391 0.081
cellular modified amino acid metabolic process GO:0006575 64 0.076
Human
negative regulation of catalytic activity GO:0043086 335 0.074
response to peptide hormone GO:0043434 61 0.073
purine ribonucleoside metabolic process GO:0046128 437 0.072
response to abiotic stimulus GO:0009628 336 0.071
sulfur compound metabolic process GO:0006790 101 0.070
single organism carbohydrate metabolic process GO:0044723 193 0.069
protein catabolic process GO:0030163 325 0.062
ribose phosphate biosynthetic process GO:0046390 82 0.060
protein oligomerization GO:0051259 173 0.060
Human
carboxylic acid biosynthetic process GO:0046394 97 0.060
regulation of cell cycle process GO:0010564 266 0.058
regulation of cellular ketone metabolic process GO:0010565 50 0.058
translation GO:0006412 132 0.057
negative regulation of apoptotic process GO:0043066 316 0.056
cell cycle phase transition GO:0044770 173 0.056
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.055
g1 s transition of mitotic cell cycle GO:0000082 78 0.055
regulation of cellular amino acid metabolic process GO:0006521 6 0.055
epithelium development GO:0060429 227 0.055
response to steroid hormone GO:0048545 80 0.055
negative regulation of organelle organization GO:0010639 126 0.054
purine nucleotide biosynthetic process GO:0006164 84 0.052
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.051
regulation of response to dna damage stimulus GO:2001020 94 0.051
mitotic cell cycle phase transition GO:0044772 162 0.050
dna repair GO:0006281 198 0.050
ribonucleoside monophosphate metabolic process GO:0009161 187 0.048
cellular response to dna damage stimulus GO:0006974 379 0.048
regulation of cell differentiation GO:0045595 393 0.047
mitotic cell cycle process GO:1903047 286 0.047
positive regulation of response to dna damage stimulus GO:2001022 43 0.047
positive regulation of dna metabolic process GO:0051054 73 0.046
secretion GO:0046903 254 0.046
glutamine family amino acid metabolic process GO:0009064 17 0.044
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.043
ribonucleotide biosynthetic process GO:0009260 81 0.043
posttranscriptional regulation of gene expression GO:0010608 213 0.043
trna metabolic process GO:0006399 35 0.042
proline transport GO:0015824 4 0.042
negative regulation of phosphate metabolic process GO:0045936 267 0.042
protein homooligomerization GO:0051260 100 0.041
cellular response to cytokine stimulus GO:0071345 181 0.039
response to insulin GO:0032868 45 0.039
cellular protein complex assembly GO:0043623 188 0.039
regulation of cellular amine metabolic process GO:0033238 11 0.038
response to oxidative stress GO:0006979 121 0.038
negative regulation of cellular protein metabolic process GO:0032269 353 0.038
alanine transport GO:0032328 3 0.037
cellular amine metabolic process GO:0044106 41 0.037
purine nucleoside monophosphate metabolic process GO:0009126 186 0.037
cellular response to nitrogen compound GO:1901699 144 0.037
cellular response to endogenous stimulus GO:0071495 336 0.037
nucleoside monophosphate metabolic process GO:0009123 191 0.036
regulation of cellular response to stress GO:0080135 244 0.036
cellular macromolecular complex assembly GO:0034622 324 0.036
carbohydrate metabolic process GO:0005975 207 0.036
mitochondrial rna metabolic process GO:0000959 15 0.036
nitrogen compound transport GO:0071705 191 0.035
positive regulation of cellular amine metabolic process GO:0033240 7 0.035
transmembrane transport GO:0055085 399 0.035
positive regulation of secretion by cell GO:1903532 108 0.034
gamma aminobutyric acid metabolic process GO:0009448 1 0.033
cellular response to hormone stimulus GO:0032870 125 0.033
ion transmembrane transport GO:0034220 338 0.033
cell division GO:0051301 168 0.033
ncrna metabolic process GO:0034660 108 0.032
vesicle mediated transport GO:0016192 371 0.032
cell development GO:0048468 328 0.031
cellular chemical homeostasis GO:0055082 180 0.031
growth GO:0040007 202 0.031
rna processing GO:0006396 255 0.031
negative regulation of protein modification process GO:0031400 200 0.031
amine metabolic process GO:0009308 44 0.031
ribonucleoside triphosphate metabolic process GO:0009199 412 0.031
response to organic cyclic compound GO:0014070 204 0.030
regulation of transferase activity GO:0051338 355 0.030
negative regulation of cell differentiation GO:0045596 171 0.030
response to peptide GO:1901652 65 0.030
peptide transport GO:0015833 74 0.029
positive regulation of catabolic process GO:0009896 310 0.029
regulation of growth GO:0040008 165 0.028
regulation of hormone secretion GO:0046883 57 0.028
positive regulation of cell cycle GO:0045787 140 0.028
purine nucleoside triphosphate catabolic process GO:0009146 392 0.028
system process GO:0003008 349 0.027
regulation of cellular component biogenesis GO:0044087 281 0.027
regulation of locomotion GO:0040012 329 0.027
metencephalon development GO:0022037 2 0.025
organophosphate catabolic process GO:0046434 430 0.025
embryo development ending in birth or egg hatching GO:0009792 34 0.025
atp metabolic process GO:0046034 176 0.025
cytoplasmic transport GO:0016482 379 0.025
cellular ketone metabolic process GO:0042180 80 0.024
secretion by cell GO:0032940 226 0.024
regulation of response to external stimulus GO:0032101 222 0.024
cellular response to organonitrogen compound GO:0071417 124 0.023
carbohydrate derivative biosynthetic process GO:1901137 207 0.023
negative regulation of phosphorus metabolic process GO:0010563 267 0.023
response to endoplasmic reticulum stress GO:0034976 49 0.023
ribonucleoside catabolic process GO:0042454 406 0.022
guanosine containing compound metabolic process GO:1901068 244 0.022
positive regulation of dna repair GO:0045739 25 0.022
purine ribonucleoside catabolic process GO:0046130 398 0.022
negative regulation of kinase activity GO:0033673 106 0.022
hexose metabolic process GO:0019318 55 0.021
regulation of nucleotide metabolic process GO:0006140 269 0.021
regulation of dna repair GO:0006282 47 0.021
hemopoiesis GO:0030097 180 0.021
negative regulation of hydrolase activity GO:0051346 182 0.021
multi organism cellular process GO:0044764 156 0.021
purine ribonucleotide catabolic process GO:0009154 404 0.020
l serine metabolic process GO:0006563 5 0.020
Human
response to acid chemical GO:0001101 66 0.020
nucleotide catabolic process GO:0009166 408 0.020
negative regulation of transferase activity GO:0051348 124 0.020
regulation of immune response GO:0050776 201 0.020
central nervous system development GO:0007417 123 0.020
negative regulation of cell death GO:0060548 345 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.020
positive regulation of cellular component organization GO:0051130 376 0.020
regulation of protein complex assembly GO:0043254 147 0.019
nucleoside triphosphate catabolic process GO:0009143 394 0.019
response to amino acid GO:0043200 14 0.019
leukocyte activation GO:0045321 164 0.019
positive regulation of immune system process GO:0002684 283 0.019
aging GO:0007568 66 0.019
response to hypoxia GO:0001666 96 0.018
endocytosis GO:0006897 159 0.018
respiratory tube development GO:0030323 20 0.018
receptor mediated endocytosis GO:0006898 84 0.018
modified amino acid transport GO:0072337 11 0.018
nuclear transport GO:0051169 179 0.018
response to lipid GO:0033993 206 0.018
positive regulation of transport GO:0051050 336 0.018
cytoplasmic translational initiation GO:0002183 6 0.018
anion transmembrane transport GO:0098656 76 0.017
positive regulation of transferase activity GO:0051347 227 0.017
negative regulation of programmed cell death GO:0043069 321 0.017
double strand break repair GO:0006302 101 0.017
response to biotic stimulus GO:0009607 276 0.017
cap independent translational initiation GO:0002190 4 0.017
immune system development GO:0002520 195 0.017
positive regulation of developmental process GO:0051094 314 0.017
negative regulation of immune system process GO:0002683 136 0.017
cellular response to peptide hormone stimulus GO:0071375 56 0.017
mitotic cell cycle GO:0000278 326 0.016
protein processing GO:0016485 226 0.016
single organism reproductive process GO:0044702 98 0.016
enzyme linked receptor protein signaling pathway GO:0007167 303 0.016
hindbrain development GO:0030902 3 0.016
positive regulation of cellular catabolic process GO:0031331 284 0.016
tube development GO:0035295 125 0.016
regulation of kinase activity GO:0043549 314 0.016
reproductive process GO:0022414 106 0.016
dna conformation change GO:0071103 113 0.016
organic anion transport GO:0015711 103 0.016
neurological system process GO:0050877 163 0.016
negative regulation of multicellular organismal process GO:0051241 317 0.015
defense response GO:0006952 315 0.015
regulation of nucleoside metabolic process GO:0009118 209 0.015
alpha amino acid biosynthetic process GO:1901607 23 0.015
cell activation GO:0001775 213 0.015
positive regulation of secretion GO:0051047 116 0.015
regulation of defense response GO:0031347 154 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.015
inorganic anion transport GO:0015698 60 0.015
regulation of protein localization GO:0032880 296 0.015
regulation of cytoskeleton organization GO:0051493 177 0.015
chromatin organization GO:0006325 351 0.015
cellular glucose homeostasis GO:0001678 11 0.015
negative regulation of cell proliferation GO:0008285 228 0.014
response to external biotic stimulus GO:0043207 261 0.014
cell cycle g1 s phase transition GO:0044843 80 0.014
small molecule catabolic process GO:0044282 92 0.014
Human
regulation of secretion GO:0051046 194 0.014
organelle assembly GO:0070925 176 0.014
glutamine metabolic process GO:0006541 2 0.014
purine nucleoside catabolic process GO:0006152 398 0.014
modification dependent macromolecule catabolic process GO:0043632 212 0.014
nucleoside triphosphate metabolic process GO:0009141 422 0.014
ribonucleotide catabolic process GO:0009261 405 0.014
positive regulation of organelle organization GO:0010638 195 0.014
regulation of cytokine production GO:0001817 232 0.014
negative regulation of phosphorylation GO:0042326 174 0.014
ion homeostasis GO:0050801 230 0.014
nucleoside catabolic process GO:0009164 408 0.014
response to oxygen levels GO:0070482 100 0.014
cytokine production GO:0001816 247 0.013
regulation of multi organism process GO:0043900 157 0.013
cellular protein catabolic process GO:0044257 261 0.013
hematopoietic or lymphoid organ development GO:0048534 186 0.013
defense response to other organism GO:0098542 129 0.013
maintenance of location GO:0051235 112 0.013
regulation of innate immune response GO:0045088 97 0.013
regulation of protein kinase activity GO:0045859 289 0.013
regulation of hormone levels GO:0010817 125 0.013
developmental process involved in reproduction GO:0003006 66 0.013
glucose homeostasis GO:0042593 31 0.013
regulation of translational initiation GO:0006446 24 0.013
response to cytokine GO:0034097 232 0.012
glycosyl compound biosynthetic process GO:1901659 27 0.012
protein acetylation GO:0006473 116 0.012
d aspartate transport GO:0070777 3 0.012
rna splicing GO:0008380 131 0.012
protein acylation GO:0043543 138 0.012
cation transmembrane transport GO:0098655 238 0.012
metal ion transport GO:0030001 272 0.012
sulfur amino acid transport GO:0000101 2 0.012
demethylation GO:0070988 37 0.012
purine nucleotide catabolic process GO:0006195 405 0.012
ires dependent translational initiation GO:0002192 4 0.012
regeneration GO:0031099 4 0.012
cellular response to insulin stimulus GO:0032869 41 0.012
actin filament based process GO:0030029 224 0.012
peptidyl tyrosine phosphorylation GO:0018108 170 0.012
immune response GO:0006955 307 0.011
rna catabolic process GO:0006401 71 0.011
pyruvate metabolic process GO:0006090 26 0.011
regulation of lipid metabolic process GO:0019216 96 0.011
glycosyl compound catabolic process GO:1901658 413 0.011
viral process GO:0016032 146 0.011
organic acid transport GO:0015849 65 0.011
apoptotic signaling pathway GO:0097190 268 0.011
regulation of viral process GO:0050792 103 0.011
mammary gland morphogenesis GO:0060443 2 0.011
reproduction GO:0000003 63 0.011
cell adhesion GO:0007155 325 0.011
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.011
negative regulation of cell cycle process GO:0010948 121 0.011
regulation of cellular component movement GO:0051270 334 0.011
regulation of anatomical structure morphogenesis GO:0022603 286 0.011
cellular response to lipid GO:0071396 127 0.011
lymphocyte activation GO:0046649 133 0.011
positive regulation of growth GO:0045927 58 0.011
negative regulation of protein phosphorylation GO:0001933 140 0.011
cation transport GO:0006812 331 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
protein tetramerization GO:0051262 47 0.011
Human
response to radiation GO:0009314 151 0.011
purine ribonucleoside biosynthetic process GO:0046129 23 0.010
ribonucleoprotein complex assembly GO:0022618 78 0.010
regulation of cell development GO:0060284 161 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.010
regulation of cell division GO:0051302 116 0.010
multicellular organism reproduction GO:0032504 42 0.010
protein maturation GO:0051604 233 0.010
patterning of blood vessels GO:0001569 2 0.010
regulation of cell adhesion GO:0030155 166 0.010
protein folding GO:0006457 38 0.010
negative regulation of protein kinase activity GO:0006469 98 0.010
purine nucleoside monophosphate catabolic process GO:0009128 158 0.010
microtubule based process GO:0007017 210 0.010
myeloid cell differentiation GO:0030099 117 0.010

SHMT2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.756
amino acid metabolic disorder DOID:9252 50 0.756
inherited metabolic disorder DOID:655 242 0.756
nervous system disease DOID:863 431 0.267
neuropathy DOID:870 52 0.267
immune system disease DOID:2914 155 0.082
central nervous system disease DOID:331 186 0.057
neuromuscular disease DOID:440 38 0.056
charcot marie tooth disease DOID:10595 33 0.025