Homo sapiens

27 known processes

SIGMAR1

sigma non-opioid intracellular receptor 1

(Aliases: OPRS1,FLJ25585,MGC3851,SRBP,SR-BP1)

SIGMAR1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular lipid metabolic process GO:0044255 303 0.896
organonitrogen compound biosynthetic process GO:1901566 200 0.446
cellular amine metabolic process GO:0044106 41 0.412
amine metabolic process GO:0009308 44 0.384
organic anion transport GO:0015711 103 0.328
transmembrane transport GO:0055085 399 0.299
lipid metabolic process GO:0006629 381 0.297
cation transport GO:0006812 331 0.263
phospholipid metabolic process GO:0006644 99 0.260
membrane lipid metabolic process GO:0006643 53 0.237
anion transport GO:0006820 161 0.226
carbohydrate derivative biosynthetic process GO:1901137 207 0.216
cellular cation homeostasis GO:0030003 163 0.199
cellular chemical homeostasis GO:0055082 180 0.190
negative regulation of cell death GO:0060548 345 0.187
organophosphate biosynthetic process GO:0090407 163 0.177
ion transmembrane transport GO:0034220 338 0.170
carboxylic acid transport GO:0046942 63 0.168
cellular amino acid metabolic process GO:0006520 116 0.162
ion homeostasis GO:0050801 230 0.158
cellular biogenic amine metabolic process GO:0006576 34 0.140
nucleotide biosynthetic process GO:0009165 109 0.138
purine ribonucleotide biosynthetic process GO:0009152 79 0.133
negative regulation of programmed cell death GO:0043069 321 0.126
purine ribonucleoside metabolic process GO:0046128 437 0.125
nucleoside phosphate biosynthetic process GO:1901293 109 0.124
cellular homeostasis GO:0019725 196 0.117
basic amino acid transport GO:0015802 3 0.110
post embryonic development GO:0009791 2 0.105
cation homeostasis GO:0055080 189 0.103
sphingolipid metabolic process GO:0006665 38 0.103
cellular ion homeostasis GO:0006873 168 0.101
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.091
alcohol metabolic process GO:0006066 114 0.090
organic hydroxy compound metabolic process GO:1901615 147 0.083
negative regulation of apoptotic process GO:0043066 316 0.075
locomotory behavior GO:0007626 1 0.071
glycerolipid metabolic process GO:0046486 107 0.070
nucleoside triphosphate metabolic process GO:0009141 422 0.068
glycerophospholipid metabolic process GO:0006650 84 0.068
chemical homeostasis GO:0048878 306 0.066
nucleoside monophosphate metabolic process GO:0009123 191 0.064
negative regulation of cell proliferation GO:0008285 228 0.064
cation transmembrane transport GO:0098655 238 0.061
regulation of cellular amino acid metabolic process GO:0006521 6 0.059
regulation of cell growth GO:0001558 135 0.058
ribonucleoside monophosphate metabolic process GO:0009161 187 0.058
carboxylic acid biosynthetic process GO:0046394 97 0.057
inorganic ion transmembrane transport GO:0098660 231 0.057
liposaccharide metabolic process GO:1903509 27 0.055
organic acid transport GO:0015849 65 0.054
oxidation reduction process GO:0055114 396 0.054
response to abiotic stimulus GO:0009628 336 0.052
nucleoside phosphate catabolic process GO:1901292 412 0.052
positive regulation of hydrolase activity GO:0051345 331 0.051
apoptotic signaling pathway GO:0097190 268 0.048
glycosylation GO:0070085 71 0.045
monocarboxylic acid biosynthetic process GO:0072330 67 0.044
nucleoside triphosphate catabolic process GO:0009143 394 0.044
regulation of nucleoside metabolic process GO:0009118 209 0.044
microtubule based process GO:0007017 210 0.042
regulation of cellular amine metabolic process GO:0033238 11 0.041
secretion GO:0046903 254 0.041
glycolipid metabolic process GO:0006664 27 0.041
response to oxygen containing compound GO:1901700 369 0.040
regulation of transferase activity GO:0051338 355 0.039
regulation of purine nucleotide metabolic process GO:1900542 264 0.039
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.039
negative regulation of protein metabolic process GO:0051248 391 0.038
ribose phosphate biosynthetic process GO:0046390 82 0.038
ribonucleoside triphosphate metabolic process GO:0009199 412 0.037
positive regulation of cellular amine metabolic process GO:0033240 7 0.037
organic acid biosynthetic process GO:0016053 97 0.037
cellular metal ion homeostasis GO:0006875 146 0.037
cellular ketone metabolic process GO:0042180 80 0.036
small gtpase mediated signal transduction GO:0007264 78 0.035
purine nucleoside triphosphate metabolic process GO:0009144 412 0.035
lipid biosynthetic process GO:0008610 177 0.034
positive regulation of apoptotic process GO:0043065 246 0.034
cdc42 protein signal transduction GO:0032488 4 0.034
negative regulation of cell cycle GO:0045786 193 0.033
purine nucleoside catabolic process GO:0006152 398 0.033
protein processing GO:0016485 226 0.033
regulation of gtpase activity GO:0043087 180 0.033
cellular response to dna damage stimulus GO:0006974 379 0.032
cell growth GO:0016049 160 0.031
regulation of growth GO:0040008 165 0.031
fatty acid metabolic process GO:0006631 115 0.031
regulation of peptidase activity GO:0052547 180 0.030
organophosphate catabolic process GO:0046434 430 0.030
negative regulation of catalytic activity GO:0043086 335 0.030
ras protein signal transduction GO:0007265 73 0.029
small molecule biosynthetic process GO:0044283 157 0.028
protein maturation GO:0051604 233 0.028
gtp metabolic process GO:0046039 239 0.028
regulation of nucleotide metabolic process GO:0006140 269 0.028
multicellular organismal aging GO:0010259 3 0.028
single organism carbohydrate metabolic process GO:0044723 193 0.028
purine nucleotide biosynthetic process GO:0006164 84 0.028
purine nucleoside monophosphate metabolic process GO:0009126 186 0.027
ethanolamine containing compound metabolic process GO:0042439 26 0.027
positive regulation of organelle organization GO:0010638 195 0.027
intrinsic apoptotic signaling pathway GO:0097193 127 0.027
growth GO:0040007 202 0.027
fatty acid biosynthetic process GO:0006633 46 0.027
lipoprotein metabolic process GO:0042157 42 0.026
single organism cellular localization GO:1902580 332 0.025
cellular response to oxygen containing compound GO:1901701 276 0.025
negative regulation of phosphorus metabolic process GO:0010563 267 0.025
purine ribonucleotide catabolic process GO:0009154 404 0.025
ribonucleoside triphosphate catabolic process GO:0009203 391 0.025
positive regulation of programmed cell death GO:0043068 249 0.025
single organism membrane organization GO:0044802 268 0.024
metal ion transport GO:0030001 272 0.024
regulation of cellular ketone metabolic process GO:0010565 50 0.024
monocarboxylic acid metabolic process GO:0032787 185 0.024
response to radiation GO:0009314 151 0.024
nitrogen compound transport GO:0071705 191 0.024
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
regulation of generation of precursor metabolites and energy GO:0043467 27 0.023
cellular divalent inorganic cation homeostasis GO:0072503 128 0.023
divalent inorganic cation homeostasis GO:0072507 136 0.023
positive regulation of cell death GO:0010942 263 0.023
cell activation GO:0001775 213 0.023
calcium ion homeostasis GO:0055074 122 0.023
negative regulation of phosphate metabolic process GO:0045936 267 0.022
positive regulation of developmental process GO:0051094 314 0.022
negative regulation of intracellular signal transduction GO:1902532 183 0.022
cellular component morphogenesis GO:0032989 314 0.021
regulation of protein localization GO:0032880 296 0.021
purine nucleotide catabolic process GO:0006195 405 0.021
purine containing compound catabolic process GO:0072523 411 0.021
regulation of apoptotic signaling pathway GO:2001233 175 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.021
positive regulation of catabolic process GO:0009896 310 0.021
regulation of kinase activity GO:0043549 314 0.021
negative regulation of protein modification process GO:0031400 200 0.021
negative regulation of protein phosphorylation GO:0001933 140 0.020
protein acylation GO:0043543 138 0.020
regulation of cell cycle GO:0051726 393 0.020
generation of precursor metabolites and energy GO:0006091 68 0.020
purine containing compound biosynthetic process GO:0072522 88 0.020
positive regulation of growth GO:0045927 58 0.020
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.020
mitochondrial transport GO:0006839 60 0.019
protein catabolic process GO:0030163 325 0.019
negative regulation of developmental process GO:0051093 247 0.019
oogenesis GO:0048477 2 0.019
amino acid transport GO:0006865 28 0.019
secretion by cell GO:0032940 226 0.019
female gamete generation GO:0007292 2 0.019
regulation of dna metabolic process GO:0051052 153 0.019
ribonucleotide biosynthetic process GO:0009260 81 0.019
activation of cdc42 gtpase activity GO:0032864 2 0.019
regulation of protein kinase activity GO:0045859 289 0.019
nucleotide catabolic process GO:0009166 408 0.018
purine nucleoside triphosphate catabolic process GO:0009146 392 0.018
monovalent inorganic cation transport GO:0015672 128 0.018
cytokine production GO:0001816 247 0.018
adult locomotory behavior GO:0008344 1 0.018
negative regulation of cell growth GO:0030308 83 0.018
cofactor metabolic process GO:0051186 87 0.018
regulation of oxidative phosphorylation GO:0002082 3 0.018
regulation of mitochondrion organization GO:0010821 54 0.017
cellular response to abiotic stimulus GO:0071214 117 0.017
regulation of proteolysis GO:0030162 293 0.017
alpha amino acid metabolic process GO:1901605 72 0.017
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.017
membrane lipid biosynthetic process GO:0046467 27 0.016
determination of adult lifespan GO:0008340 2 0.016
response to oxidative stress GO:0006979 121 0.016
regulation of ras protein signal transduction GO:0046578 155 0.016
cellular response to cytokine stimulus GO:0071345 181 0.016
hemopoiesis GO:0030097 180 0.016
regulation of intracellular ph GO:0051453 16 0.016
positive regulation of cellular component organization GO:0051130 376 0.016
cell development GO:0048468 328 0.016
dna conformation change GO:0071103 113 0.016
regulation of cellular response to stress GO:0080135 244 0.015
nucleoside monophosphate catabolic process GO:0009125 159 0.015
biological adhesion GO:0022610 331 0.015
negative regulation of multicellular organismal process GO:0051241 317 0.015
vesicle mediated transport GO:0016192 371 0.015
ribonucleotide catabolic process GO:0009261 405 0.015
rho protein signal transduction GO:0007266 26 0.015
system process GO:0003008 349 0.015
atp metabolic process GO:0046034 176 0.015
membrane organization GO:0061024 292 0.015
protein oligomerization GO:0051259 173 0.015
anion transmembrane transport GO:0098656 76 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
positive regulation of cell proliferation GO:0008284 301 0.015
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.014
alcohol biosynthetic process GO:0046165 52 0.014
negative regulation of growth GO:0045926 97 0.014
response to inorganic substance GO:0010035 127 0.014
response to ionizing radiation GO:0010212 65 0.014
response to growth factor GO:0070848 205 0.014
negative regulation of protein kinase activity GO:0006469 98 0.014
negative regulation of phosphorylation GO:0042326 174 0.014
cell adhesion GO:0007155 325 0.013
positive regulation of cellular catabolic process GO:0031331 284 0.013
organelle localization GO:0051640 84 0.013
chromatin organization GO:0006325 351 0.013
purine ribonucleoside catabolic process GO:0046130 398 0.013
response to biotic stimulus GO:0009607 276 0.013
regulation of endopeptidase activity GO:0052548 170 0.013
ribonucleoside catabolic process GO:0042454 406 0.013
protein targeting GO:0006605 187 0.013
purine ribonucleoside biosynthetic process GO:0046129 23 0.013
innate immune response GO:0045087 178 0.013
intracellular protein transport GO:0006886 270 0.013
nuclear transport GO:0051169 179 0.013
monovalent inorganic cation homeostasis GO:0055067 37 0.013
cellular amide metabolic process GO:0043603 69 0.013
protein glycosylation GO:0006486 62 0.012
response to other organism GO:0051707 261 0.012
negative regulation of transferase activity GO:0051348 124 0.012
covalent chromatin modification GO:0016569 254 0.012
positive regulation of proteolysis GO:0045862 142 0.012
organophosphate ester transport GO:0015748 32 0.012
glycosyl compound catabolic process GO:1901658 413 0.012
regulation of immune response GO:0050776 201 0.012
regulation of protein stability GO:0031647 87 0.012
response to cytokine GO:0034097 232 0.012
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
leukocyte activation GO:0045321 164 0.012
lytic vacuole organization GO:0080171 24 0.012
nucleoside catabolic process GO:0009164 408 0.012
negative regulation of hydrolase activity GO:0051346 182 0.012
ceramide metabolic process GO:0006672 25 0.012
immune response GO:0006955 307 0.012
cellular response to radiation GO:0071478 65 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.012
proton transport GO:0015992 22 0.012
negative regulation of cellular component organization GO:0051129 235 0.012
negative regulation of kinase activity GO:0033673 106 0.012
epithelium development GO:0060429 227 0.012
cell cycle phase transition GO:0044770 173 0.012
regulation of feeding behavior GO:0060259 3 0.011
regulation of protein catabolic process GO:0042176 155 0.011
vitamin metabolic process GO:0006766 26 0.011
anatomical structure formation involved in morphogenesis GO:0048646 284 0.011
negative regulation of apoptotic signaling pathway GO:2001234 97 0.011
positive regulation of peptidase activity GO:0010952 88 0.011
arginine transport GO:0015809 2 0.011
cellular modified amino acid metabolic process GO:0006575 64 0.011
dna replication GO:0006260 116 0.011
response to external biotic stimulus GO:0043207 261 0.011
negative regulation of protein processing GO:0010955 142 0.011
glycoprotein metabolic process GO:0009100 110 0.011
positive regulation of endopeptidase activity GO:0010950 84 0.011
positive regulation of gtp catabolic process GO:0033126 166 0.011
response to light stimulus GO:0009416 87 0.010
regulation of protein localization to cell surface GO:2000008 15 0.010
cellular macromolecular complex assembly GO:0034622 324 0.010
nucleoside biosynthetic process GO:0009163 26 0.010
establishment of vesicle localization GO:0051650 23 0.010
mitotic cell cycle phase transition GO:0044772 162 0.010
protein transmembrane transport GO:0071806 25 0.010
regulation of anatomical structure morphogenesis GO:0022603 286 0.010
regulation of protein processing GO:0070613 150 0.010
establishment of organelle localization GO:0051656 59 0.010
myosin filament organization GO:0031033 2 0.010
protein secretion GO:0009306 98 0.010
protein localization to cell surface GO:0034394 28 0.010
myosin filament assembly GO:0031034 2 0.010
phospholipid biosynthetic process GO:0008654 44 0.010
developmental growth GO:0048589 48 0.010
microtubule cytoskeleton organization GO:0000226 176 0.010
establishment of protein localization to organelle GO:0072594 172 0.010

SIGMAR1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.969
inherited metabolic disorder DOID:655 242 0.969
carbohydrate metabolic disorder DOID:2978 55 0.232
congenital disorder of glycosylation DOID:5212 26 0.232
congenital disorder of glycosylation type i DOID:0050570 16 0.108
cancer DOID:162 167 0.026
disease of cellular proliferation DOID:14566 174 0.026
organ system cancer DOID:0050686 164 0.017
central nervous system disease DOID:331 186 0.014
nervous system disease DOID:863 431 0.014
lipid storage disease DOID:9455 28 0.013
lysosomal storage disease DOID:3211 47 0.013
neuronal ceroid lipofuscinosis DOID:14503 11 0.013
immune system disease DOID:2914 155 0.011
neurodegenerative disease DOID:1289 102 0.002
motor neuron disease DOID:231 27 0.002
amyotrophic lateral sclerosis DOID:332 20 0.002