|
|
regulation of cyclase activity
|
GO:0031279 |
19 |
1.000
|
Human |
|
|
adenylate cyclase inhibiting adrenergic receptor signaling pathway
|
GO:0071881 |
1 |
1.000
|
|
|
|
adenylate cyclase modulating g protein coupled receptor signaling pathway
|
GO:0007188 |
43 |
1.000
|
Mouse |
|
|
negative regulation of insulin secretion involved in cellular response to glucose stimulus
|
GO:0061179 |
1 |
1.000
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.999
|
|
|
|
phospholipase c activating adrenergic receptor signaling pathway
|
GO:0071882 |
1 |
0.998
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.998
|
Human |
|
|
adenylate cyclase inhibiting serotonin receptor signaling pathway
|
GO:0007198 |
2 |
0.997
|
|
|
|
rab protein signal transduction
|
GO:0032482 |
4 |
0.997
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.992
|
Human |
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.990
|
Human Mouse |
|
|
positive regulation of rab gtpase activity
|
GO:0032851 |
39 |
0.988
|
|
|
|
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger
|
GO:0007187 |
43 |
0.986
|
Mouse |
|
|
cyclic nucleotide biosynthetic process
|
GO:0009190 |
61 |
0.980
|
Human |
|
|
serotonin receptor signaling pathway
|
GO:0007210 |
11 |
0.971
|
|
|
|
regulation of membrane potential
|
GO:0042391 |
95 |
0.969
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.963
|
|
|
|
negative regulation of nucleotide biosynthetic process
|
GO:0030809 |
11 |
0.960
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.957
|
|
|
|
negative regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042518 |
2 |
0.957
|
|
|
|
regulation of cyclic nucleotide metabolic process
|
GO:0030799 |
63 |
0.951
|
Human |
|
|
inorganic anion transmembrane transport
|
GO:0098661 |
47 |
0.950
|
|
|
|
positive regulation of phosphatidylinositol biosynthetic process
|
GO:0010513 |
3 |
0.949
|
|
|
|
organic hydroxy compound transport
|
GO:0015850 |
63 |
0.948
|
Human Mouse |
|
|
hippo signaling
|
GO:0035329 |
20 |
0.945
|
|
|
|
regulation of rab gtpase activity
|
GO:0032313 |
39 |
0.934
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.933
|
|
|
|
regulation of purine nucleotide biosynthetic process
|
GO:1900371 |
50 |
0.932
|
Human |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.928
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.927
|
Human |
|
|
regulation of blood vessel size
|
GO:0050880 |
18 |
0.918
|
|
|
|
regulation of nucleotide biosynthetic process
|
GO:0030808 |
50 |
0.910
|
Human |
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.909
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.908
|
|
|
|
regulation of rab protein signal transduction
|
GO:0032483 |
39 |
0.905
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.895
|
Zebrafish Mouse |
|
|
positive regulation of transmembrane transport
|
GO:0034764 |
41 |
0.893
|
Human |
|
|
positive regulation of vasodilation
|
GO:0045909 |
4 |
0.893
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.885
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.881
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.879
|
Human |
|
|
activation of mapk activity by adrenergic receptor signaling pathway
|
GO:0071883 |
3 |
0.878
|
|
|
|
cyclic purine nucleotide metabolic process
|
GO:0052652 |
60 |
0.867
|
Human |
|
|
cation transport
|
GO:0006812 |
331 |
0.866
|
Human Mouse |
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.864
|
Mouse |
|
|
dopamine receptor signaling pathway
|
GO:0007212 |
10 |
0.864
|
Mouse |
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.861
|
|
|
|
negative regulation of jak stat cascade
|
GO:0046426 |
4 |
0.856
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.854
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.854
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.847
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.845
|
Zebrafish |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.842
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.841
|
Mouse |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.839
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.839
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.836
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.836
|
Mouse |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.833
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.824
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.819
|
Human |
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.803
|
|
|
|
nucleotide biosynthetic process
|
GO:0009165 |
109 |
0.798
|
Human |
|
|
desensitization of g protein coupled receptor protein signaling pathway by arrestin
|
GO:0002032 |
2 |
0.787
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.780
|
Mouse |
|
|
negative regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014067 |
4 |
0.777
|
Mouse |
|
|
purinergic nucleotide receptor signaling pathway
|
GO:0035590 |
4 |
0.772
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.767
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.761
|
Zebrafish |
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.750
|
Human |
|
|
metaphase anaphase transition of cell cycle
|
GO:0044784 |
21 |
0.744
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.725
|
Human |
|
|
camp biosynthetic process
|
GO:0006171 |
47 |
0.725
|
|
|
|
negative regulation of cyclic nucleotide biosynthetic process
|
GO:0030803 |
10 |
0.724
|
Human |
|
|
hormone transport
|
GO:0009914 |
68 |
0.723
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.714
|
Mouse |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.711
|
|
|
|
bicarbonate transport
|
GO:0015701 |
6 |
0.709
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.709
|
Human |
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.708
|
|
|
|
negative regulation of protein kinase b signaling
|
GO:0051898 |
17 |
0.704
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.701
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.700
|
|
|
|
negative regulation of tyrosine phosphorylation of stat protein
|
GO:0042532 |
2 |
0.700
|
|
|
|
regulation of camp biosynthetic process
|
GO:0030817 |
45 |
0.697
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.693
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.688
|
|
|
|
negative regulation of cgmp metabolic process
|
GO:0030824 |
1 |
0.687
|
Human |
|
|
hormone secretion
|
GO:0046879 |
65 |
0.687
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.685
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.675
|
Human Mouse |
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.673
|
|
|
|
retrograde transport endosome to golgi
|
GO:0042147 |
45 |
0.671
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.670
|
Human |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.664
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.663
|
|
|
|
tyrosine phosphorylation of stat3 protein
|
GO:0042503 |
20 |
0.661
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.652
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.652
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.644
|
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
84 |
0.643
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.640
|
|
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.638
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.626
|
|
|
|
potassium ion transport
|
GO:0006813 |
62 |
0.625
|
|
|
|
sensory perception of pain
|
GO:0019233 |
4 |
0.624
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.620
|
Human |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.620
|
|
|
|
negative regulation of secretion by cell
|
GO:1903531 |
52 |
0.615
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.615
|
Human Mouse |
|
|
regulation of tube size
|
GO:0035150 |
18 |
0.605
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.605
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.601
|
|
|
|
negative regulation of nucleotide metabolic process
|
GO:0045980 |
29 |
0.598
|
Human |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.593
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.575
|
Mouse |
|
|
positive regulation of ion transmembrane transport
|
GO:0034767 |
40 |
0.574
|
Human |
|
|
heart contraction
|
GO:0060047 |
62 |
0.570
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.566
|
|
|
|
vasodilation
|
GO:0042311 |
4 |
0.560
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.559
|
|
|
|
adenylate cyclase activating dopamine receptor signaling pathway
|
GO:0007191 |
3 |
0.558
|
Mouse |
|
|
regulation of lymphocyte migration
|
GO:2000401 |
22 |
0.554
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.552
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.552
|
|
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.550
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.550
|
Human |
|
|
cgmp metabolic process
|
GO:0046068 |
19 |
0.547
|
Human |
|
|
regulation of mitotic sister chromatid separation
|
GO:0010965 |
27 |
0.540
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.539
|
Mouse |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.538
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.532
|
|
|
|
negative regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042524 |
1 |
0.531
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.531
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.529
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.521
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.520
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.520
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.519
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.519
|
|
|
|
negative regulation of neurological system process
|
GO:0031645 |
2 |
0.518
|
|
|
|
regulation of lyase activity
|
GO:0051339 |
23 |
0.516
|
Human |
|
|
regulation of vasodilation
|
GO:0042312 |
4 |
0.503
|
|
|
|
diet induced thermogenesis
|
GO:0002024 |
2 |
0.501
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.500
|
|
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
20 |
0.499
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.494
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.492
|
|
|
|
regulation of nuclear division
|
GO:0051783 |
65 |
0.491
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.490
|
Mouse |
|
|
positive regulation of camp biosynthetic process
|
GO:0030819 |
35 |
0.486
|
|
|
|
negative regulation of platelet aggregation
|
GO:0090331 |
3 |
0.486
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.484
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.473
|
|
|
|
anterior posterior axis specification embryo
|
GO:0008595 |
2 |
0.472
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.471
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.471
|
|
|
|
negative regulation of blood pressure
|
GO:0045776 |
3 |
0.467
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.467
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.462
|
|
|
|
protein localization to plasma membrane
|
GO:0072659 |
93 |
0.450
|
|
|
|
adenylate cyclase activating adrenergic receptor signaling pathway
|
GO:0071880 |
3 |
0.449
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.447
|
|
|
|
epidermal growth factor activated receptor transactivation by g protein coupled receptor signaling pathway
|
GO:0035625 |
4 |
0.441
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.427
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.425
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.419
|
Mouse |
|
|
regulation of mitotic sister chromatid segregation
|
GO:0033047 |
27 |
0.419
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.413
|
Zebrafish |
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.411
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.410
|
|
|
|
adenylate cyclase activating g protein coupled receptor signaling pathway
|
GO:0007189 |
18 |
0.409
|
Mouse |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.408
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.405
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.401
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.401
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.398
|
|
|
|
activation of phospholipase c activity
|
GO:0007202 |
7 |
0.397
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.391
|
|
|
|
regulation of guanylate cyclase activity
|
GO:0031282 |
2 |
0.389
|
Human |
|
|
purine nucleotide biosynthetic process
|
GO:0006164 |
84 |
0.384
|
Human |
|
|
zymogen activation
|
GO:0031638 |
70 |
0.382
|
|
|
|
lymphocyte migration
|
GO:0072676 |
28 |
0.377
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.375
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.373
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.370
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.368
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.364
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.364
|
|
|
|
organelle assembly
|
GO:0070925 |
176 |
0.364
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.363
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.361
|
|
|
|
receptor internalization
|
GO:0031623 |
43 |
0.361
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.356
|
|
|
|
chloride transport
|
GO:0006821 |
41 |
0.355
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.355
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.354
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.350
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.349
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.344
|
|
|
|
positive regulation of adenylate cyclase activity
|
GO:0045762 |
12 |
0.344
|
|
|
|
regulation of camp metabolic process
|
GO:0030814 |
52 |
0.344
|
|
|
|
positive regulation of camp metabolic process
|
GO:0030816 |
41 |
0.342
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.342
|
Worm |
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.341
|
Zebrafish |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.339
|
|
|
|
regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042522 |
12 |
0.339
|
|
|
|
membrane to membrane docking
|
GO:0022614 |
5 |
0.338
|
|
|
|
renal system process
|
GO:0003014 |
25 |
0.337
|
|
|
|
plasma membrane organization
|
GO:0007009 |
115 |
0.334
|
|
|
|
positive regulation of inositol trisphosphate biosynthetic process
|
GO:0032962 |
1 |
0.332
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.330
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.328
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.327
|
|
|
|
amino acid betaine transport
|
GO:0015838 |
4 |
0.324
|
Human |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.323
|
Human Mouse |
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.322
|
|
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.319
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.313
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.312
|
|
|
|
phospholipase c activating dopamine receptor signaling pathway
|
GO:0060158 |
2 |
0.312
|
Mouse |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.307
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.303
|
Mouse |
|
|
glomerular mesangial cell proliferation
|
GO:0072110 |
3 |
0.302
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.302
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.301
|
Mouse |
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.297
|
|
|
|
negative regulation of dna replication
|
GO:0008156 |
29 |
0.296
|
|
|
|
cardiac muscle cell contraction
|
GO:0086003 |
4 |
0.296
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.295
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.294
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.294
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.293
|
Mouse |
|
|
cell migration involved in gastrulation
|
GO:0042074 |
1 |
0.293
|
|
|
|
vascular process in circulatory system
|
GO:0003018 |
29 |
0.292
|
|
|
|
respiratory system development
|
GO:0060541 |
22 |
0.292
|
|
|
|
regulation of chemotaxis
|
GO:0050920 |
74 |
0.292
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.292
|
|
|
|
positive regulation of inositol phosphate biosynthetic process
|
GO:0060732 |
2 |
0.289
|
|
|
|
skeletal muscle tissue growth
|
GO:0048630 |
2 |
0.288
|
|
|
|
regulation of muscle system process
|
GO:0090257 |
53 |
0.287
|
|
|
|
copulation
|
GO:0007620 |
1 |
0.285
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.284
|
|
|
|
regulation of anion channel activity
|
GO:0010359 |
2 |
0.282
|
|
|
|
regulation of sensory perception of pain
|
GO:0051930 |
3 |
0.281
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.276
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.275
|
|
|
|
positive regulation of nucleotide biosynthetic process
|
GO:0030810 |
38 |
0.275
|
|
|
|
chloride transmembrane transport
|
GO:1902476 |
38 |
0.273
|
|
|
|
chromosome separation
|
GO:0051304 |
23 |
0.272
|
|
|
|
positive regulation of multicellular organismal metabolic process
|
GO:0044253 |
11 |
0.271
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.269
|
|
|
|
positive regulation of camp mediated signaling
|
GO:0043950 |
10 |
0.267
|
|
|
|
negative regulation of secretion
|
GO:0051048 |
58 |
0.263
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.262
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.262
|
|
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.260
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.259
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.258
|
|
|
|
positive regulation of calcium ion transport into cytosol
|
GO:0010524 |
20 |
0.257
|
|
|
|
regulation of lipid catabolic process
|
GO:0050994 |
23 |
0.257
|
|
|
|
positive regulation of cytosolic calcium ion concentration involved in phospholipase c activating g protein coupled signaling pathway
|
GO:0051482 |
6 |
0.256
|
|
|
|
regulation of muscle contraction
|
GO:0006937 |
45 |
0.256
|
|
|
|
negative regulation of cyclic nucleotide metabolic process
|
GO:0030800 |
10 |
0.256
|
Human |
|
|
skeletal muscle contraction
|
GO:0003009 |
16 |
0.255
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.253
|
|
|
|
sensory perception
|
GO:0007600 |
103 |
0.250
|
Mouse |
|
|
receptor transactivation
|
GO:0035624 |
4 |
0.250
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.248
|
|
|
|
receptor mediated endocytosis
|
GO:0006898 |
84 |
0.248
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.247
|
Zebrafish |
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.244
|
|
|
|
musculoskeletal movement
|
GO:0050881 |
17 |
0.244
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.244
|
|
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.244
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.241
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.240
|
Mouse |
|
|
positive regulation of cyclic nucleotide metabolic process
|
GO:0030801 |
49 |
0.240
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.239
|
Human |
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.239
|
|
|
|
intestine smooth muscle contraction
|
GO:0014827 |
2 |
0.238
|
|
|
|
positive regulation of ossification
|
GO:0045778 |
32 |
0.237
|
|
|
|
adenylate cyclase inhibiting g protein coupled receptor signaling pathway
|
GO:0007193 |
22 |
0.237
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.236
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.234
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.234
|
|
|
|
regulation of postsynaptic membrane potential
|
GO:0060078 |
1 |
0.233
|
|
|
|
regulation of multicellular organismal metabolic process
|
GO:0044246 |
17 |
0.233
|
|
|
|
organic anion transport
|
GO:0015711 |
103 |
0.233
|
Human Mouse |
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.231
|
Human |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.231
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.227
|
Mouse |
|
|
positive regulation of purine nucleotide biosynthetic process
|
GO:1900373 |
38 |
0.227
|
|
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.225
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.223
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.223
|
Mouse |
|
|
myosin filament assembly
|
GO:0031034 |
2 |
0.223
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.221
|
|
|
|
trachea development
|
GO:0060438 |
1 |
0.220
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.217
|
Mouse |
|
|
organelle fission
|
GO:0048285 |
149 |
0.216
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.212
|
|
|
|
oligodendrocyte development
|
GO:0014003 |
6 |
0.205
|
|
|
|
positive regulation of lipid biosynthetic process
|
GO:0046889 |
22 |
0.204
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.202
|
|
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.202
|
Human |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.202
|
|
|
|
presynaptic membrane organization
|
GO:0097090 |
3 |
0.200
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.198
|
|
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.198
|
|
|
|
regulation of leukocyte migration
|
GO:0002685 |
63 |
0.194
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.194
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.192
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.192
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.191
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.190
|
|
|
|
organic hydroxy compound biosynthetic process
|
GO:1901617 |
71 |
0.190
|
|
|
|
regulation of hormone secretion
|
GO:0046883 |
57 |
0.190
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.189
|
|
|
|
regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042516 |
18 |
0.188
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.188
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.187
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.187
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.187
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.187
|
|
|
|
regulation of the force of heart contraction by chemical signal
|
GO:0003057 |
1 |
0.187
|
|
|
|
lipid catabolic process
|
GO:0016042 |
84 |
0.186
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.186
|
|
|
|
negative regulation of purine nucleotide biosynthetic process
|
GO:1900372 |
11 |
0.186
|
Human |
|
|
striated muscle contraction
|
GO:0006941 |
52 |
0.184
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.184
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.183
|
|
|
|
protein kinase c signaling
|
GO:0070528 |
17 |
0.180
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
51 |
0.180
|
|
|
|
response to dietary excess
|
GO:0002021 |
2 |
0.178
|
|
|
|
regulation of phosphatidylinositol biosynthetic process
|
GO:0010511 |
5 |
0.178
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.177
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.174
|
|
|
|
regulation of atpase activity
|
GO:0043462 |
25 |
0.173
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.173
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.172
|
|
|
|
establishment of endothelial barrier
|
GO:0061028 |
16 |
0.171
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.170
|
|
|
|
negative regulation of blood coagulation
|
GO:0030195 |
22 |
0.169
|
|
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.169
|
|
|
|
muscle cell development
|
GO:0055001 |
29 |
0.169
|
|
|
|
negative regulation of muscle contraction
|
GO:0045932 |
3 |
0.166
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.166
|
|
|
|
regulation of atp metabolic process
|
GO:1903578 |
29 |
0.165
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.164
|
|
|
|
regulation of camp mediated signaling
|
GO:0043949 |
13 |
0.164
|
|
|
|
startle response
|
GO:0001964 |
3 |
0.163
|
|
|
|
regulation of systemic arterial blood pressure mediated by a chemical signal
|
GO:0003044 |
12 |
0.161
|
|
|
|
positive regulation of intrinsic apoptotic signaling pathway
|
GO:2001244 |
28 |
0.161
|
|
|
|
peptide transport
|
GO:0015833 |
74 |
0.160
|
Mouse |
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.159
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.159
|
|
|
|
platelet aggregation
|
GO:0070527 |
32 |
0.159
|
|
|
|
transepithelial transport
|
GO:0070633 |
9 |
0.159
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.159
|
|
|
|
muscle contraction
|
GO:0006936 |
73 |
0.155
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.154
|
Mouse |
|
|
calcium mediated signaling
|
GO:0019722 |
44 |
0.154
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.152
|
|
|
|
mitotic sister chromatid separation
|
GO:0051306 |
18 |
0.152
|
|
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.151
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.151
|
|
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.150
|
|
|
|
sodium ion transmembrane transport
|
GO:0035725 |
59 |
0.149
|
Mouse |
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.148
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.145
|
Worm |
|
|
regulation of hemostasis
|
GO:1900046 |
42 |
0.144
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.144
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.143
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.143
|
|
|
|
phospholipid biosynthetic process
|
GO:0008654 |
44 |
0.142
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.142
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.142
|
|
|
|
kidney morphogenesis
|
GO:0060993 |
19 |
0.140
|
|
|
|
negative regulation of cyclase activity
|
GO:0031280 |
6 |
0.139
|
Human |
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.138
|
|
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.138
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.137
|
Mouse |
|
|
regulation of coagulation
|
GO:0050818 |
44 |
0.137
|
|
|
|
endothelial cell development
|
GO:0001885 |
18 |
0.137
|
|
|
|
positive regulation of potassium ion transport
|
GO:0043268 |
15 |
0.136
|
|
|
|
negative regulation of erk1 and erk2 cascade
|
GO:0070373 |
14 |
0.135
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.134
|
Zebrafish |
|
|
sister chromatid segregation
|
GO:0000819 |
54 |
0.134
|
|
|
|
regulation of inositol phosphate biosynthetic process
|
GO:0010919 |
3 |
0.134
|
|
|
|
multicellular organismal movement
|
GO:0050879 |
17 |
0.133
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.132
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.132
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.132
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.131
|
|
|
|
regulation of chromosome segregation
|
GO:0051983 |
44 |
0.129
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.128
|
Zebrafish |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.128
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.127
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.127
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.126
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.126
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.124
|
|
|
|
regulation of sequestering of calcium ion
|
GO:0051282 |
41 |
0.122
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.122
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.121
|
Mouse |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.121
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.121
|
|
|
|
activation of protein kinase b activity
|
GO:0032148 |
14 |
0.119
|
|
|
|
negative regulation of purine nucleotide metabolic process
|
GO:1900543 |
28 |
0.117
|
Human |
|
|
g protein coupled purinergic nucleotide receptor signaling pathway
|
GO:0035589 |
1 |
0.116
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.116
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.115
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.115
|
|
|
|
regulation of chloride transport
|
GO:2001225 |
2 |
0.115
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.114
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.113
|
|
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.113
|
Mouse |
|
|
nervous system development
|
GO:0007399 |
293 |
0.112
|
Mouse |
|
|
regulation of sister chromatid segregation
|
GO:0033045 |
27 |
0.110
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.110
|
|
|
|
cellular component assembly involved in morphogenesis
|
GO:0010927 |
73 |
0.110
|
|
|
|
cellular response to decreased oxygen levels
|
GO:0036294 |
51 |
0.109
|
|
|
|
negative regulation of mapk cascade
|
GO:0043409 |
56 |
0.109
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.109
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.107
|
|
|
|
tripartite regional subdivision
|
GO:0007351 |
2 |
0.106
|
|
|
|
regulation of cyclic nucleotide biosynthetic process
|
GO:0030802 |
49 |
0.105
|
Human |
|
|
regulation of sodium ion transmembrane transport
|
GO:1902305 |
23 |
0.104
|
Mouse |
|
|
cell adhesion
|
GO:0007155 |
325 |
0.104
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.104
|
|
|
|
respiratory gaseous exchange
|
GO:0007585 |
3 |
0.103
|
|
|
|
atp catabolic process
|
GO:0006200 |
157 |
0.103
|
|
|
|
negative regulation of dendritic spine development
|
GO:0061000 |
1 |
0.102
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
47 |
0.102
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.102
|
Mouse |
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.100
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.100
|
|
|
|
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process
|
GO:0031145 |
25 |
0.099
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.099
|
Mouse |
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.099
|
Mouse |
|
|
striated muscle myosin thick filament assembly
|
GO:0071688 |
2 |
0.099
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.099
|
|
|
|
negative regulation of peptide hormone secretion
|
GO:0090278 |
10 |
0.098
|
|
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.097
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.097
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.096
|
|
|
|
adrenergic receptor signaling pathway
|
GO:0071875 |
9 |
0.096
|
|
|
|
regulation of protein kinase b signaling
|
GO:0051896 |
61 |
0.095
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.095
|
Mouse |
|
|
establishment or maintenance of epithelial cell apical basal polarity
|
GO:0045197 |
1 |
0.094
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.093
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.093
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.093
|
Mouse |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.093
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.092
|
|
|
|
glial cell migration
|
GO:0008347 |
4 |
0.092
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.092
|
|
|
|
presynaptic membrane assembly
|
GO:0097105 |
1 |
0.092
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.092
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
46 |
0.092
|
|
|
|
positive regulation of actin filament bundle assembly
|
GO:0032233 |
25 |
0.091
|
|
|
|
regulation of blood pressure
|
GO:0008217 |
30 |
0.090
|
|
|
|
positive regulation of membrane potential
|
GO:0045838 |
2 |
0.089
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.089
|
|
|
|
regulation of metanephric mesenchymal cell migration
|
GO:2000589 |
2 |
0.088
|
|
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.088
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.087
|
|
|
|
monocarboxylic acid transport
|
GO:0015718 |
32 |
0.087
|
Human Mouse |
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.087
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.087
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.086
|
|
|
|
regulation of stress fiber assembly
|
GO:0051492 |
32 |
0.085
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.085
|
|
|
|
biomineral tissue development
|
GO:0031214 |
39 |
0.085
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.084
|
|
|
|
memory
|
GO:0007613 |
3 |
0.084
|
|
|
|
myosin filament organization
|
GO:0031033 |
2 |
0.084
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.084
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.084
|
Mouse |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.084
|
Mouse |
