Homo sapiens

78 known processes

SMAD1

SMAD family member 1

(Aliases: BSP1,JV41,MADH1,MADR1,JV4-1)

SMAD1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of activin receptor signaling pathway GO:0032925 14 1.000
Human
response to host defenses GO:0052200 2 1.000
Human
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 2 1.000
Mouse
zygotic specification of dorsal ventral axis GO:0007352 2 1.000
Human
hard palate development GO:0060022 1 1.000
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003257 3 1.000
positive regulation of mesoderm development GO:2000382 2 1.000
Human
regulation of mesoderm development GO:2000380 4 1.000
Human
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 1.000
Human
response to host GO:0075136 2 1.000
Human
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 1 1.000
Human
negative regulation of pathway restricted smad protein phosphorylation GO:0060394 11 1.000
Human
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.999
Human
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 1 0.999
Human
activin receptor signaling pathway GO:0032924 24 0.999
Human
avoidance of host defenses GO:0044413 2 0.999
Human
bmp signaling pathway GO:0030509 49 0.999
evasion or tolerance of host defenses GO:0044415 2 0.999
Human
positive regulation of bmp signaling pathway GO:0030513 9 0.998
Human
pathway restricted smad protein phosphorylation GO:0060389 38 0.998
Human
mesonephros development GO:0001823 17 0.998
Mouse
negative regulation of transcription by competitive promoter binding GO:0010944 8 0.997
Human
response to defenses of other organism involved in symbiotic interaction GO:0052173 2 0.997
Human
enzyme linked receptor protein signaling pathway GO:0007167 303 0.997
regulation of stem cell differentiation GO:2000736 56 0.997
Human
mesenchymal cell development GO:0014031 50 0.996
Human
cellular response to endogenous stimulus GO:0071495 336 0.996
Human Mouse Fly
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.996
Human Fly
mesenchyme development GO:0060485 59 0.996
Human
ureteric bud development GO:0001657 13 0.996
Mouse
negative regulation of peptidyl threonine phosphorylation GO:0010801 6 0.996
Human
cellular response to growth factor stimulus GO:0071363 197 0.996
Human Mouse Fly
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.995
Human Fly
positive regulation of transcription factor import into nucleus GO:0042993 25 0.994
Human
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.993
Human
avoidance of defenses of other organism involved in symbiotic interaction GO:0051832 2 0.993
Human
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.992
Human
cell cycle arrest GO:0007050 71 0.992
Human
determination of left right asymmetry in lateral mesoderm GO:0003140 1 0.992
Human
transforming growth factor beta production GO:0071604 14 0.992
Human
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.991
Human
stem cell differentiation GO:0048863 93 0.989
Human Fly
viral process GO:0016032 146 0.989
Human
lateral mesoderm development GO:0048368 1 0.988
Human
regulation of cell cycle GO:0051726 393 0.987
Human Worm Fly
regulation of epithelial to mesenchymal transition GO:0010717 37 0.986
Human
multi organism cellular process GO:0044764 156 0.986
Human
positive regulation of osteoblast differentiation GO:0045669 23 0.986
Mouse
regulation of pathway restricted smad protein phosphorylation GO:0060393 34 0.986
Human
kidney epithelium development GO:0072073 25 0.985
Mouse
negative regulation of cell differentiation GO:0045596 171 0.985
Fly
modulation by virus of host morphology or physiology GO:0019048 10 0.984
Human
positive regulation of stem cell differentiation GO:2000738 29 0.984
Human
negative regulation of peptidyl serine phosphorylation GO:0033137 8 0.982
Human
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.982
Human
regulation of canonical wnt signaling pathway GO:0060828 88 0.980
Human
positive regulation of cellular protein catabolic process GO:1903364 37 0.980
Human
common partner smad protein phosphorylation GO:0007182 3 0.979
Human
evasion or tolerance of host defenses by virus GO:0019049 2 0.979
Human
response to cholesterol GO:0070723 11 0.979
Human
circulatory system development GO:0072359 262 0.977
Mouse
regulation of cellular response to growth factor stimulus GO:0090287 76 0.976
Human
epithelial to mesenchymal transition GO:0001837 48 0.976
Human
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.972
Human
regulation of bmp signaling pathway GO:0030510 27 0.970
Human
negative regulation of ligase activity GO:0051352 8 0.970
Human
regulation of mrna export from nucleus GO:0010793 3 0.970
positive regulation of protein catabolic process GO:0045732 75 0.969
Human
response to growth factor GO:0070848 205 0.969
Human Mouse Fly
negative regulation of ubiquitin protein transferase activity GO:0051444 8 0.966
Human
regulation of meiotic cell cycle GO:0051445 4 0.963
Worm
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.962
Human
regulation of proteasomal protein catabolic process GO:0061136 87 0.961
Human
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.961
regulation of ubiquitin protein transferase activity GO:0051438 28 0.961
Human
negative regulation of bmp signaling pathway GO:0030514 17 0.961
Human
evasion or tolerance of defenses of other organism involved in symbiotic interaction GO:0051834 2 0.958
Human
peptidyl threonine phosphorylation GO:0018107 41 0.957
Human
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 1 0.957
Human
negative regulation of cell proliferation GO:0008285 228 0.957
Human Mouse
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.956
Human
endodermal cell fate commitment GO:0001711 4 0.955
Fly
positive regulation of cell death GO:0010942 263 0.955
Human
negative regulation of sodium ion transmembrane transporter activity GO:2000650 2 0.953
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.952
Human
mesenchymal cell differentiation GO:0048762 52 0.950
Human
regulation of cytokine production GO:0001817 232 0.950
Human
regulation of isoprenoid metabolic process GO:0019747 1 0.946
positive regulation of proteolysis GO:0045862 142 0.945
Human
positive regulation of programmed cell death GO:0043068 249 0.943
Human
regulation of transferase activity GO:0051338 355 0.943
Human
negative regulation of cell cycle GO:0045786 193 0.942
Human Worm Fly
mesonephric tubule development GO:0072164 14 0.939
Mouse
negative regulation of sodium ion transmembrane transport GO:1902306 2 0.938
negative regulation of developmental process GO:0051093 247 0.936
Fly
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.933
Human
negative regulation of smad protein complex assembly GO:0010991 4 0.931
Human
vasculature development GO:0001944 181 0.927
transmission of virus GO:0019089 1 0.926
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.925
Human
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.925
Human Rat
endodermal cell fate specification GO:0001714 4 0.917
Fly
regulation of nodal signaling pathway GO:1900107 1 0.916
Human
cardiac muscle tissue development GO:0048738 39 0.915
Mouse
positive regulation of protein import into nucleus GO:0042307 46 0.914
Human
regulation of establishment of protein localization GO:0070201 242 0.914
Human
interaction with host GO:0051701 42 0.913
Human
regulation of cell differentiation GO:0045595 393 0.910
Human Mouse Rat Fly
regulation of nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900175 1 0.905
Human
dorsal ventral pattern formation GO:0009953 15 0.900
Human Zebrafish
response to transforming growth factor beta GO:0071559 94 0.899
Human Fly
positive regulation of apoptotic process GO:0043065 246 0.898
Human
intraciliary transport GO:0042073 7 0.897
endocardial cushion development GO:0003197 3 0.893
neuromuscular junction development GO:0007528 3 0.891
Fly
development involved in symbiotic interaction GO:0044111 1 0.888
positive regulation of developmental process GO:0051094 314 0.884
Human Mouse Rat Worm Fly
cardiovascular system development GO:0072358 262 0.884
Mouse
negative regulation of phosphorus metabolic process GO:0010563 267 0.880
Human
regulation of protein ubiquitination GO:0031396 95 0.877
Human
regulation of endopeptidase activity GO:0052548 170 0.876
Human
ubiquitin dependent endocytosis GO:0070086 1 0.875
positive regulation of intracellular protein transport GO:0090316 76 0.874
Human
regulation of nodal signaling pathway involved in determination of left right asymmetry GO:1900145 1 0.870
Human
positive regulation of peptidase activity GO:0010952 88 0.870
Human
negative regulation of cell fate specification GO:0009996 3 0.868
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.867
Human
smad protein signal transduction GO:0060395 10 0.867
Human
trna transport GO:0051031 1 0.857
regulation of ligase activity GO:0051340 29 0.856
Human
positive regulation of transcription from rna polymerase ii promoter involved in heart development GO:1901228 3 0.853
positive regulation of epithelial to mesenchymal transition GO:0010718 22 0.852
Human
negative regulation of muscle organ development GO:0048635 12 0.845
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.840
Human
regulation of peptidase activity GO:0052547 180 0.838
Human
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.837
Human Rat
response to decreased oxygen levels GO:0036293 96 0.835
Human
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.835
Human
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.833
Human
myeloid cell differentiation GO:0030099 117 0.830
Zebrafish
positive regulation of endopeptidase activity GO:0010950 84 0.822
Human
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.821
Human
stem cell maintenance GO:0019827 19 0.820
Fly
activation of cysteine type endopeptidase activity GO:0097202 57 0.814
Human
trna export from nucleus GO:0006409 1 0.810
regulation of cell cell adhesion GO:0022407 57 0.803
Human
canonical wnt signaling pathway GO:0060070 116 0.802
Human
negative regulation of mitotic cell cycle GO:0045930 102 0.802
Human Worm Fly
retinal ganglion cell axon guidance GO:0031290 2 0.800
protein targeting to nucleus GO:0044744 104 0.798
Human
regulation of muscle organ development GO:0048634 27 0.798
response to other organism GO:0051707 261 0.797
Human
regulation of osteoblast differentiation GO:0045667 38 0.791
Mouse
somatic stem cell maintenance GO:0035019 4 0.790
Fly
embryonic heart tube morphogenesis GO:0003143 8 0.789
protein localization to organelle GO:0033365 280 0.787
Human
transforming growth factor beta2 production GO:0032906 6 0.787
Human
cellular macromolecule catabolic process GO:0044265 380 0.783
Human
regulation of muscle system process GO:0090257 53 0.782
regulation of smad protein complex assembly GO:0010990 4 0.779
Human
negative regulation of cell fate commitment GO:0010454 3 0.778
regulation of transcription factor import into nucleus GO:0042990 39 0.778
Human
heart morphogenesis GO:0003007 48 0.777
ubiquitin dependent protein catabolic process GO:0006511 206 0.774
Human
response to fluid shear stress GO:0034405 14 0.772
Human
nucleocytoplasmic transport GO:0006913 176 0.772
Human
smad protein complex assembly GO:0007183 12 0.771
establishment of protein localization to organelle GO:0072594 172 0.771
Human
regulation of cellular component biogenesis GO:0044087 281 0.767
Human Fly
embryonic morphogenesis GO:0048598 85 0.766
Mouse Fly
single organismal cell cell adhesion GO:0016337 148 0.763
Human
tissue migration GO:0090130 119 0.762
mesonephric epithelium development GO:0072163 14 0.755
Mouse
muscle system process GO:0003012 81 0.747
protein modification by small protein conjugation GO:0032446 342 0.743
Human
protein localization to nucleus GO:0034504 136 0.741
Human
positive regulation of cell differentiation GO:0045597 211 0.737
Human Mouse Rat
regulation of transforming growth factor beta production GO:0071634 13 0.736
Human
response to lipid GO:0033993 206 0.733
Human
regulation of alkaline phosphatase activity GO:0010692 2 0.729
negative regulation of protein phosphorylation GO:0001933 140 0.728
Human
growth GO:0040007 202 0.717
Human Mouse Worm Fly
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.709
Human
regulation of cellular protein catabolic process GO:1903362 96 0.709
Human
polyprenol biosynthetic process GO:0016094 1 0.705
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900224 1 0.702
Human
amine metabolic process GO:0009308 44 0.701
nervous system development GO:0007399 293 0.700
Mouse Rat Fly
positive regulation of protein transport GO:0051222 135 0.698
Human
organ formation GO:0048645 3 0.696
cell projection organization GO:0030030 252 0.695
Rat
cell junction assembly GO:0034329 67 0.694
Human
cellular component morphogenesis GO:0032989 314 0.693
Human Rat
positive regulation of protein ubiquitination GO:0031398 53 0.685
Human
modification by symbiont of host morphology or physiology GO:0044003 12 0.680
Human
nodal signaling pathway GO:0038092 5 0.679
Human
polyprenol metabolic process GO:0016093 3 0.673
regulation of nucleocytoplasmic transport GO:0046822 98 0.671
Human
response to abiotic stimulus GO:0009628 336 0.668
Human
dorsal ventral axis specification GO:0009950 7 0.667
Human
positive regulation of cytoplasmic transport GO:1903651 82 0.667
Human
negative regulation of cell growth GO:0030308 83 0.663
Human
adherens junction organization GO:0034332 36 0.662
Human
peptidyl threonine modification GO:0018210 45 0.660
Human
negative regulation of striated muscle tissue development GO:0045843 11 0.660
response to organic cyclic compound GO:0014070 204 0.658
Human Mouse
stem cell division GO:0017145 2 0.657
Fly
positive regulation of cellular catabolic process GO:0031331 284 0.650
Human
regulation of growth GO:0040008 165 0.648
Human Worm Fly
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.646
Human
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.643
Human
regulation of cell morphogenesis GO:0022604 153 0.643
Human Rat
mesoderm development GO:0007498 14 0.639
Human Mouse
proteasomal protein catabolic process GO:0010498 176 0.632
Human
ribosomal large subunit export from nucleus GO:0000055 3 0.630
kidney development GO:0001822 53 0.628
Mouse Rat
positive regulation of protein phosphorylation GO:0001934 313 0.619
protein complex localization GO:0031503 31 0.619
Human
regulation of nervous system development GO:0051960 88 0.617
Rat Fly
blood vessel development GO:0001568 172 0.615
protein import into nucleus GO:0006606 104 0.612
Human
cell adhesion GO:0007155 325 0.612
Human
immune response GO:0006955 307 0.611
Human
cell part morphogenesis GO:0032990 137 0.603
Rat
mitotic cell cycle GO:0000278 326 0.599
Human Worm Fly
regulation of anatomical structure morphogenesis GO:0022603 286 0.598
Human Rat
positive regulation of catabolic process GO:0009896 310 0.596
Human
cytokine production GO:0001816 247 0.595
Human
cellular amino acid metabolic process GO:0006520 116 0.593
negative regulation of sodium ion transport GO:0010766 3 0.590
cellular amine metabolic process GO:0044106 41 0.590
response to external biotic stimulus GO:0043207 261 0.589
Human
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.587
Human
cell morphogenesis GO:0000902 296 0.585
Human Rat
extrinsic apoptotic signaling pathway GO:0097191 119 0.584
Human
catenin import into nucleus GO:0035411 18 0.584
Human
regulation of cysteine type endopeptidase activity GO:2000116 127 0.583
Human
regulation of protein catabolic process GO:0042176 155 0.583
Human
regulation of protein serine threonine kinase activity GO:0071900 179 0.579
regulation of endothelial cell migration GO:0010594 67 0.578
negative regulation of catalytic activity GO:0043086 335 0.576
Human
regulation of ribosome biogenesis GO:0090069 1 0.576
muscle structure development GO:0061061 98 0.575
regulation of cell development GO:0060284 161 0.571
Human Rat
chromatin organization GO:0006325 351 0.569
otic vesicle development GO:0071599 1 0.567
regulation of smooth muscle cell differentiation GO:0051150 3 0.564
regulation of cellular amine metabolic process GO:0033238 11 0.561
positive regulation of wnt signaling pathway GO:0030177 54 0.556
Human
regulation of cartilage development GO:0061035 12 0.555
Mouse
nuclear import GO:0051170 106 0.552
Human
embryonic axis specification GO:0000578 5 0.551
Human
response to biotic stimulus GO:0009607 276 0.550
Human
peptidyl serine modification GO:0018209 106 0.550
Human
tube morphogenesis GO:0035239 95 0.549
Mouse Fly
response to oxygen levels GO:0070482 100 0.541
Human
protein targeting GO:0006605 187 0.534
Human
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.532
Human
determination of bilateral symmetry GO:0009855 15 0.532
Human
dissemination or transmission of symbiont from host GO:0044007 1 0.527
blood vessel morphogenesis GO:0048514 162 0.527
regulation of ketone biosynthetic process GO:0010566 7 0.524
stem cell development GO:0048864 69 0.524
Human Fly
cell morphogenesis involved in differentiation GO:0000904 144 0.524
Human Rat
negative regulation of catabolic process GO:0009895 104 0.520
Human
cellular response to bmp stimulus GO:0071773 8 0.518
Mouse
anatomical structure formation involved in morphogenesis GO:0048646 284 0.517
Mouse Fly
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.515
regulation of protein localization GO:0032880 296 0.514
Human
zymogen activation GO:0031638 70 0.513
Human
regulation of protein import into nucleus GO:0042306 78 0.512
Human
regulation of catenin import into nucleus GO:0035412 18 0.510
Human
cell fate commitment GO:0045165 27 0.507
Mouse Fly
regulation of protein transport GO:0051223 213 0.507
Human
negative regulation of protein modification process GO:0031400 200 0.503
Human
dissemination or transmission of organism from other organism involved in symbiotic interaction GO:0051821 1 0.502
regulation of system process GO:0044057 101 0.500
negative regulation of multicellular organismal process GO:0051241 317 0.500
organ morphogenesis GO:0009887 147 0.499
Fly
ameboidal type cell migration GO:0001667 135 0.499
positive regulation of cell development GO:0010720 92 0.492
Human Rat
positive regulation of transcription via serum response element binding GO:0010735 3 0.490
regulation of cellular ketone metabolic process GO:0010565 50 0.486
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.485
cell migration involved in gastrulation GO:0042074 1 0.484
positive regulation of hydrolase activity GO:0051345 331 0.481
Human
atrioventricular valve development GO:0003171 3 0.479
response to oxygen containing compound GO:1901700 369 0.473
Human
gland development GO:0048732 48 0.472
mitotic cell cycle phase transition GO:0044772 162 0.464
Fly
digestive tract morphogenesis GO:0048546 56 0.460
Mouse Fly
muscle cell fate commitment GO:0042693 4 0.454
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.453
Human
regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation GO:0003256 3 0.451
negative regulation of gliogenesis GO:0014014 3 0.449
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.449
Fly
striated muscle tissue development GO:0014706 59 0.442
Mouse
potassium ion transport GO:0006813 62 0.435
regulation of transcription from rna polymerase ii promoter in response to uv induced dna damage GO:0010767 1 0.435
extraocular skeletal muscle development GO:0002074 1 0.430
dolichol biosynthetic process GO:0019408 1 0.428
negative regulation of growth GO:0045926 97 0.428
Human
specification of symmetry GO:0009799 16 0.410
Human
regulation of rrna processing GO:2000232 1 0.409
protein ubiquitination GO:0016567 314 0.407
Human
chemotaxis GO:0006935 157 0.406
Fly
endoderm formation GO:0001706 33 0.403
Fly
quinone biosynthetic process GO:1901663 6 0.403
negative regulation of cellular amine metabolic process GO:0033239 3 0.402
positive regulation of intracellular transport GO:0032388 104 0.402
Human
protein import GO:0017038 130 0.402
Human
epithelium development GO:0060429 227 0.399
Mouse Fly
response to alcohol GO:0097305 64 0.398
Human
negative regulation of glial cell proliferation GO:0060253 2 0.389
regulation of intracellular transport GO:0032386 195 0.387
Human
pattern specification process GO:0007389 43 0.386
Human Zebrafish Fly
cellular ketone metabolic process GO:0042180 80 0.385
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.383
epithelial cell differentiation GO:0030855 141 0.382
Fly
sodium ion transmembrane transport GO:0035725 59 0.380
negative regulation of transcription from rna polymerase ii promoter in response to uv induced dna damage GO:0010768 1 0.379
regulation of cell cycle process GO:0010564 266 0.378
Fly
intracellular protein transport GO:0006886 270 0.378
Human
modification dependent protein catabolic process GO:0019941 209 0.370
Human
neuron differentiation GO:0030182 138 0.368
Rat
positive regulation of map kinase activity GO:0043406 80 0.368
positive regulation of catenin import into nucleus GO:0035413 9 0.363
Human
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.359
single organism nuclear import GO:1902593 104 0.358
Human
negative regulation of phosphorylation GO:0042326 174 0.358
Human
determination of left right symmetry GO:0007368 11 0.357
Human
regulation of synapse assembly GO:0051963 5 0.355
Fly
modification dependent macromolecule catabolic process GO:0043632 212 0.354
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.353
Human
regulation of epithelial cell proliferation GO:0050678 113 0.350
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.349
regulation of peptidyl serine phosphorylation GO:0033135 50 0.348
Human
mapk cascade GO:0000165 288 0.339
Mouse Rat
cell development GO:0048468 328 0.333
Human Zebrafish Rat Fly
cell substrate adhesion GO:0031589 132 0.329
Human
erythrocyte differentiation GO:0030218 28 0.326
regulation of cell adhesion GO:0030155 166 0.325
Human
adherens junction assembly GO:0034333 34 0.324
Human
positive regulation of cellular component organization GO:0051130 376 0.322
Human Rat Fly
bone development GO:0060348 26 0.321
Mouse
fat cell differentiation GO:0045444 32 0.321
Human
regulation of epithelial cell migration GO:0010632 93 0.320
regulation of intracellular protein transport GO:0033157 123 0.311
Human
regulation of protein kinase activity GO:0045859 289 0.309
interspecies interaction between organisms GO:0044419 156 0.307
Human
cell proliferation involved in heart valve development GO:2000793 1 0.306
cell junction organization GO:0034330 79 0.305
Human
cellular protein complex localization GO:0034629 8 0.303
Human
progesterone receptor signaling pathway GO:0050847 3 0.302
neuron fate commitment GO:0048663 2 0.302
blastoderm segmentation GO:0007350 2 0.301
Fly
connective tissue development GO:0061448 39 0.300
Mouse
generation of neurons GO:0048699 152 0.294
Rat
negative regulation of protein catabolic process GO:0042177 59 0.294
Human
positive regulation of cell cell adhesion GO:0022409 22 0.292
Human
single organism cellular localization GO:1902580 332 0.287
Human
cellular protein complex assembly GO:0043623 188 0.283
heart development GO:0007507 95 0.278
Mouse
compound eye development GO:0048749 1 0.276
Fly
negative regulation of apoptotic process GO:0043066 316 0.274
Human Rat
protein catabolic process GO:0030163 325 0.269
Human
monovalent inorganic cation transport GO:0015672 128 0.269
endodermal cell differentiation GO:0035987 31 0.267
Fly
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.265
endothelial cell migration GO:0043542 86 0.262
response to laminar fluid shear stress GO:0034616 8 0.260
Human
positive regulation of transport GO:0051050 336 0.254
Human
negative regulation of cellular component organization GO:0051129 235 0.252
Human
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.251
Human
dephosphorylation GO:0016311 209 0.250
lens morphogenesis in camera type eye GO:0002089 2 0.249
chordate embryonic development GO:0043009 34 0.248
intracellular receptor signaling pathway GO:0030522 104 0.248
regulation of mapk cascade GO:0043408 262 0.247
pharynx development GO:0060465 1 0.244
positive regulation of mapk cascade GO:0043410 190 0.244
cardiac chamber development GO:0003205 30 0.242
histone h4 k12 acetylation GO:0043983 6 0.241
cardiac muscle contraction GO:0060048 34 0.238
heart valve formation GO:0003188 2 0.234
epidermal cell differentiation GO:0009913 45 0.233
cell cell junction organization GO:0045216 69 0.233
Human
angiogenesis GO:0001525 147 0.231
regulation of immune response GO:0050776 201 0.228
nuclear transport GO:0051169 179 0.227
Human
negative regulation of cell development GO:0010721 48 0.227
regulation of protein stability GO:0031647 87 0.226
Human
cell fate specification GO:0001708 8 0.223
Fly
regulation of peptidyl threonine phosphorylation GO:0010799 15 0.219
Human
embryonic heart tube development GO:0035050 9 0.216
cardiocyte differentiation GO:0035051 23 0.215
regulation of mitotic cell cycle GO:0007346 189 0.213
Human Worm Fly
embryonic organ morphogenesis GO:0048562 24 0.212
muscle contraction GO:0006936 73 0.210
convergent extension GO:0060026 1 0.208
protein maturation GO:0051604 233 0.208
Human
ventricular septum morphogenesis GO:0060412 3 0.207
embryonic hemopoiesis GO:0035162 4 0.207
tube development GO:0035295 125 0.204
Mouse Fly
negative regulation of transferase activity GO:0051348 124 0.204
Human
response to sterol GO:0036314 14 0.203
Human
negative regulation of programmed cell death GO:0043069 321 0.202
Human Rat
biological adhesion GO:0022610 331 0.201
Human
negative regulation of protein ubiquitination GO:0031397 35 0.200
Human
ectodermal cell fate specification GO:0001715 1 0.199
regulation of kinase activity GO:0043549 314 0.199
regulation of transforming growth factor beta2 production GO:0032909 6 0.198
Human
negative regulation of phosphate metabolic process GO:0045936 267 0.198
Human
response to hypoxia GO:0001666 96 0.196
Human
negative regulation of beta amyloid clearance GO:1900222 3 0.196
regulation of protein localization to nucleus GO:1900180 85 0.196
Human
convergent extension involved in gastrulation GO:0060027 1 0.194
urogenital system development GO:0001655 65 0.194
Mouse Rat Fly
positive regulation of activin receptor signaling pathway GO:0032927 6 0.194
Human
regulation of proteolysis GO:0030162 293 0.192
Human
oogenesis GO:0048477 2 0.189
Fly
osteoblast differentiation GO:0001649 92 0.189
Mouse
apoptotic signaling pathway GO:0097190 268 0.189
Human
positive regulation of locomotion GO:0040017 186 0.188
embryonic organ development GO:0048568 36 0.188
smooth muscle cell differentiation GO:0051145 8 0.187
regulation of cell growth GO:0001558 135 0.186
Human
negative regulation of protein metabolic process GO:0051248 391 0.185
Human
neuron projection development GO:0031175 106 0.185
Rat
negative regulation of defense response GO:0031348 47 0.185
neural tube formation GO:0001841 3 0.184
organ induction GO:0001759 4 0.183
hematopoietic or lymphoid organ development GO:0048534 186 0.181
Zebrafish
pericardium development GO:0060039 2 0.180
septum secundum development GO:0003285 2 0.177
regulation of multivesicular body size GO:0010796 1 0.177
establishment of ribosome localization GO:0033753 4 0.171
ear morphogenesis GO:0042471 7 0.171
protein autoubiquitination GO:0051865 37 0.171
peptidyl serine phosphorylation GO:0018105 101 0.171
Human
regulation of cell migration GO:0030334 289 0.169
regulation of potassium ion transmembrane transport GO:1901379 20 0.169
post embryonic development GO:0009791 2 0.168
Fly
morphogenesis of embryonic epithelium GO:0016331 4 0.167
cofactor metabolic process GO:0051186 87 0.166
regulation of heart morphogenesis GO:2000826 4 0.166
regulation of potassium ion transmembrane transporter activity GO:1901016 16 0.165
canonical wnt signaling pathway involved in osteoblast differentiation GO:0044339 2 0.164
histone acetylation GO:0016573 93 0.159
regulation of mitotic cell cycle phase transition GO:1901990 118 0.157
Fly
regulation of bone mineralization GO:0030500 29 0.156
actin cytoskeleton organization GO:0030036 207 0.156
glial cell migration GO:0008347 4 0.154
segmentation GO:0035282 4 0.152
Fly
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.152
i kappab kinase nf kappab signaling GO:0007249 166 0.151
monocarboxylic acid biosynthetic process GO:0072330 67 0.151
system process GO:0003008 349 0.151
sensory organ morphogenesis GO:0090596 21 0.151
Fly
g2 m transition of mitotic cell cycle GO:0000086 41 0.150
ras protein signal transduction GO:0007265 73 0.147
androgen receptor signaling pathway GO:0030521 34 0.147
regulation of cytoplasmic transport GO:1903649 149 0.146
Human
memory GO:0007613 3 0.145
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.145
immune system development GO:0002520 195 0.144
Zebrafish
heart looping GO:0001947 7 0.143
cell division GO:0051301 168 0.143
Fly
actin filament based process GO:0030029 224 0.143
wnt signaling pathway GO:0016055 156 0.141
Human
single organism cell adhesion GO:0098602 179 0.139
Human
cellular protein catabolic process GO:0044257 261 0.139
Human
regulation of potassium ion transport GO:0043266 24 0.138
positive regulation of cardiac muscle cell differentiation GO:2000727 4 0.136
isoprenoid metabolic process GO:0006720 39 0.135
blood vessel endothelial cell migration GO:0043534 42 0.134
regulation of transmembrane transporter activity GO:0022898 74 0.132
motor neuron axon guidance GO:0008045 2 0.131
positive regulation of immune system process GO:0002684 283 0.131
negative regulation of multi organism process GO:0043901 92 0.130
protein stabilization GO:0050821 64 0.130
Human
muscle organ development GO:0007517 56 0.130
drinking behavior GO:0042756 1 0.127
sensory organ development GO:0007423 52 0.127
Fly
potassium ion transmembrane transport GO:0071805 60 0.126

SMAD1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.820
Human
disease of cellular proliferation DOID:14566 174 0.820
Human
bone disease DOID:0080001 88 0.782
musculoskeletal system disease DOID:17 223 0.782
connective tissue disease DOID:65 109 0.782
organ system cancer DOID:0050686 164 0.514
Human
gonadal disease DOID:2277 8 0.188
endocrine system disease DOID:28 26 0.188
reproductive system disease DOID:15 17 0.188