Homo sapiens

0 known processes

SMAD5

SMAD family member 5

(Aliases: DKFZp781O1323,DWFC,DKFZp781C1895,JV5-1,MADH5)

SMAD5 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 2 1.000
Mouse
evasion or tolerance of host defenses GO:0044415 2 1.000
Human
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 0.994
Human
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.984
Human Mouse Fly
response to growth factor GO:0070848 205 0.984
Human Mouse Fly
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.981
Human Mouse Fly
regulation of activin receptor signaling pathway GO:0032925 14 0.978
Human
regulation of pathway restricted smad protein phosphorylation GO:0060393 34 0.973
Human
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.971
Human Zebrafish Mouse Fly
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.969
Human
response to host GO:0075136 2 0.969
Human
protein localization to organelle GO:0033365 280 0.962
Human
transforming growth factor beta production GO:0071604 14 0.960
Human
negative regulation of pathway restricted smad protein phosphorylation GO:0060394 11 0.960
Human
dissemination or transmission of symbiont from host GO:0044007 1 0.957
avoidance of host defenses GO:0044413 2 0.953
Human
response to host defenses GO:0052200 2 0.950
Human
response to defenses of other organism involved in symbiotic interaction GO:0052173 2 0.947
Human
avoidance of defenses of other organism involved in symbiotic interaction GO:0051832 2 0.942
Human
positive regulation of stem cell differentiation GO:2000738 29 0.940
Human
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.937
Human Zebrafish
negative regulation of sodium ion transmembrane transporter activity GO:2000650 2 0.935
regulation of mrna export from nucleus GO:0010793 3 0.926
cellular response to endogenous stimulus GO:0071495 336 0.923
Human Mouse Fly
regulation of cellular response to growth factor stimulus GO:0090287 76 0.914
Human
determination of left right asymmetry in lateral mesoderm GO:0003140 1 0.908
Human
lateral mesoderm development GO:0048368 1 0.903
Human
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.902
Human
modification dependent macromolecule catabolic process GO:0043632 212 0.890
Human
interspecies interaction between organisms GO:0044419 156 0.882
Human
mesodermal cell fate commitment GO:0001710 2 0.879
positive regulation of mesoderm development GO:2000382 2 0.860
Human
retinal ganglion cell axon guidance GO:0031290 2 0.860
negative regulation of bmp signaling pathway GO:0030514 17 0.853
Human
cellular response to growth factor stimulus GO:0071363 197 0.844
Human Mouse Fly
development involved in symbiotic interaction GO:0044111 1 0.842
positive regulation of osteoblast differentiation GO:0045669 23 0.834
Mouse
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 0.831
Human
regulation of proteolysis GO:0030162 293 0.819
Human
regulation of nucleocytoplasmic transport GO:0046822 98 0.806
Human
regulation of ketone biosynthetic process GO:0010566 7 0.792
zygotic specification of dorsal ventral axis GO:0007352 2 0.789
Human
negative regulation of sodium ion transport GO:0010766 3 0.785
regulation of nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900175 1 0.785
Human
ubiquitin dependent endocytosis GO:0070086 1 0.785
evasion or tolerance of defenses of other organism involved in symbiotic interaction GO:0051834 2 0.779
Human
positive regulation of bmp signaling pathway GO:0030513 9 0.778
Human
regulation of proteasomal protein catabolic process GO:0061136 87 0.776
Human
smad protein complex assembly GO:0007183 12 0.773
Human
regulation of nodal signaling pathway involved in determination of left right asymmetry GO:1900145 1 0.763
Human
regulation of meiotic cell cycle GO:0051445 4 0.758
Worm
nuclear transport GO:0051169 179 0.757
Human
positive regulation of transcription factor import into nucleus GO:0042993 25 0.752
Human
modulation by virus of host morphology or physiology GO:0019048 10 0.747
Human
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.741
Human
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.740
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.734
Human
viral process GO:0016032 146 0.729
Human
endodermal cell fate commitment GO:0001711 4 0.726
Fly
negative regulation of smad protein complex assembly GO:0010991 4 0.723
Human
positive regulation of proteolysis GO:0045862 142 0.710
Human
trna transport GO:0051031 1 0.709
endodermal cell differentiation GO:0035987 31 0.699
Fly
interaction with host GO:0051701 42 0.693
Human
negative regulation of sodium ion transmembrane transport GO:1902306 2 0.683
mesenchymal cell development GO:0014031 50 0.680
Human
modification dependent protein catabolic process GO:0019941 209 0.670
Human
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.659
Human
regulation of canonical wnt signaling pathway GO:0060828 88 0.658
Human
regulation of nodal signaling pathway GO:1900107 1 0.656
Human
neuron differentiation GO:0030182 138 0.652
regulation of protein import into nucleus GO:0042306 78 0.650
Human
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.645
Human
cell cycle arrest GO:0007050 71 0.637
Human
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.636
Human
activin receptor signaling pathway GO:0032924 24 0.635
Human
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.633
Human
multi organism cellular process GO:0044764 156 0.627
Human
ribosomal large subunit export from nucleus GO:0000055 3 0.620
post embryonic development GO:0009791 2 0.618
Fly
vasculature development GO:0001944 181 0.607
Zebrafish
peptidyl threonine modification GO:0018210 45 0.601
Human
bmp signaling pathway GO:0030509 49 0.595
Human Zebrafish Mouse Fly
regulation of smad protein complex assembly GO:0010990 4 0.592
Human
osteoblast differentiation GO:0001649 92 0.577
Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.571
trna export from nucleus GO:0006409 1 0.565
endodermal cell fate specification GO:0001714 4 0.558
Fly
endoderm formation GO:0001706 33 0.554
Fly
regulation of cartilage development GO:0061035 12 0.551
regulation of mesoderm development GO:2000380 4 0.546
Human
regulation of cell cycle GO:0051726 393 0.536
Human Worm Fly
regulation of protein localization GO:0032880 296 0.535
Human
positive regulation of cellular catabolic process GO:0031331 284 0.535
Human
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900224 1 0.527
Human
regulation of transcription factor import into nucleus GO:0042990 39 0.523
Human
cellular ketone metabolic process GO:0042180 80 0.519
positive regulation of wnt signaling pathway GO:0030177 54 0.515
Human
neurogenesis GO:0022008 169 0.504
mesonephros development GO:0001823 17 0.504
Mouse
nervous system development GO:0007399 293 0.499
Fly
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.496
Human
proteasomal protein catabolic process GO:0010498 176 0.494
Human
regulation of epithelial to mesenchymal transition GO:0010717 37 0.486
Human
negative regulation of cell growth GO:0030308 83 0.485
Human
cellular macromolecule catabolic process GO:0044265 380 0.485
Human
common partner smad protein phosphorylation GO:0007182 3 0.483
Human
chemotaxis GO:0006935 157 0.482
Fly
response to external biotic stimulus GO:0043207 261 0.478
Human
negative regulation of apoptotic process GO:0043066 316 0.474
Human
positive regulation of developmental process GO:0051094 314 0.471
Human Mouse Worm Fly
negative regulation of ubiquitin protein transferase activity GO:0051444 8 0.467
Human
positive regulation of cytoplasmic transport GO:1903651 82 0.460
Human
cellular amine metabolic process GO:0044106 41 0.453
nucleocytoplasmic transport GO:0006913 176 0.446
Human
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.445
Human
cellular protein catabolic process GO:0044257 261 0.445
Human
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.441
Human
regulation of bmp signaling pathway GO:0030510 27 0.440
Human Zebrafish
regulation of establishment of protein localization GO:0070201 242 0.438
Human
skeletal system development GO:0001501 79 0.424
Mouse
inorganic ion transmembrane transport GO:0098660 231 0.421
regulation of anatomical structure morphogenesis GO:0022603 286 0.421
Human Zebrafish
regulation of protein transport GO:0051223 213 0.414
Human
regulation of protein catabolic process GO:0042176 155 0.409
Human
positive regulation of catabolic process GO:0009896 310 0.403
Human
mitotic cell cycle GO:0000278 326 0.393
Human Worm Fly
dissemination or transmission of organism from other organism involved in symbiotic interaction GO:0051821 1 0.392
positive regulation of intracellular transport GO:0032388 104 0.389
Human
organ morphogenesis GO:0009887 147 0.388
Zebrafish Fly
embryo development GO:0009790 123 0.388
Human Zebrafish Fly
positive regulation of transport GO:0051050 336 0.380
Human
epithelium development GO:0060429 227 0.379
Zebrafish Mouse Fly
negative regulation of cellular amine metabolic process GO:0033239 3 0.375
protein ubiquitination GO:0016567 314 0.370
Human
adherens junction organization GO:0034332 36 0.366
Human
monovalent inorganic cation transport GO:0015672 128 0.359
establishment of protein localization to organelle GO:0072594 172 0.357
Human
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.355
negative regulation of cell cycle GO:0045786 193 0.354
Human Worm Fly
kidney epithelium development GO:0072073 25 0.354
Mouse
positive regulation of hydrolase activity GO:0051345 331 0.350
Human
regulation of osteoblast differentiation GO:0045667 38 0.343
Mouse
cellular component morphogenesis GO:0032989 314 0.342
Human
regulation of transcription from rna polymerase ii promoter in response to uv induced dna damage GO:0010767 1 0.340
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.336
Human
regulation of epithelial cell migration GO:0010632 93 0.333
sodium ion transmembrane transport GO:0035725 59 0.328
positive regulation of cellular protein catabolic process GO:1903364 37 0.324
Human
regulation of intracellular transport GO:0032386 195 0.313
Human
defense response GO:0006952 315 0.313
ribonucleoprotein complex biogenesis GO:0022613 116 0.311
growth GO:0040007 202 0.311
Human Worm Fly
cell projection organization GO:0030030 252 0.308
positive regulation of ossification GO:0045778 32 0.308
Mouse
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 1 0.307
Human
transforming growth factor beta2 production GO:0032906 6 0.304
Human
cell fate commitment involved in formation of primary germ layer GO:0060795 6 0.299
Fly
regulation of growth GO:0040008 165 0.297
Human Worm Fly
regulation of ligase activity GO:0051340 29 0.293
Human
response to laminar fluid shear stress GO:0034616 8 0.289
Human
regulation of multivesicular body size GO:0010796 1 0.287
polyprenol metabolic process GO:0016093 3 0.287
evasion or tolerance of host defenses by virus GO:0019049 2 0.286
Human
pathway restricted smad protein phosphorylation GO:0060389 38 0.285
Human
cytokine production GO:0001816 247 0.282
Human
negative regulation of transcription from rna polymerase ii promoter in response to uv induced dna damage GO:0010768 1 0.282
negative regulation of protein metabolic process GO:0051248 391 0.280
Human
hindbrain development GO:0030902 3 0.279
amine metabolic process GO:0009308 44 0.278
single organism nuclear import GO:1902593 104 0.277
Human
protein modification by small protein conjugation GO:0032446 342 0.276
Human
endothelium development GO:0003158 33 0.276
canonical wnt signaling pathway GO:0060070 116 0.275
Human
protein catabolic process GO:0030163 325 0.270
Human
inorganic cation transmembrane transport GO:0098662 194 0.269
negative regulation of cellular protein metabolic process GO:0032269 353 0.266
Human
neuromuscular junction development GO:0007528 3 0.265
Fly
response to transforming growth factor beta GO:0071559 94 0.263
Human Mouse Fly
regulation of mitotic cell cycle GO:0007346 189 0.262
Human Worm Fly
regulation of ribosome biogenesis GO:0090069 1 0.256
protein import into nucleus GO:0006606 104 0.256
Human
cytoplasmic transport GO:0016482 379 0.254
Human
positive regulation of cell cycle GO:0045787 140 0.254
Worm
negative regulation of growth GO:0045926 97 0.248
Human
ion homeostasis GO:0050801 230 0.247
ubiquitin dependent protein catabolic process GO:0006511 206 0.246
Human
cell morphogenesis GO:0000902 296 0.246
Human
regulation of cellular amine metabolic process GO:0033238 11 0.245
regulation of intracellular protein transport GO:0033157 123 0.244
Human
receptor catabolic process GO:0032801 11 0.241
response to other organism GO:0051707 261 0.239
Human
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.237
Human
regulation of cellular protein catabolic process GO:1903362 96 0.237
Human
cellular response to bmp stimulus GO:0071773 8 0.236
Mouse
negative regulation of cell cycle g1 s phase transition GO:1902807 29 0.234
Fly
regulation of stem cell differentiation GO:2000736 56 0.232
Human
positive regulation of dendrite morphogenesis GO:0050775 3 0.231
negative regulation of mitotic cell cycle GO:0045930 102 0.230
Human Worm Fly
negative regulation of glial cell proliferation GO:0060253 2 0.228
chromatin assembly or disassembly GO:0006333 78 0.225
intracellular protein transport GO:0006886 270 0.224
Human
tube development GO:0035295 125 0.222
Zebrafish Mouse Fly
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.221
Human
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 1 0.221
Human Zebrafish
cell adhesion GO:0007155 325 0.220
Human
metal ion transport GO:0030001 272 0.217
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.212
Human
polyprenol biosynthetic process GO:0016094 1 0.209
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 0.208
negative regulation of cell differentiation GO:0045596 171 0.207
Fly
potassium ion transport GO:0006813 62 0.207
cell morphogenesis involved in differentiation GO:0000904 144 0.205
Human
wnt signaling pathway GO:0016055 156 0.204
Human
negative regulation of gliogenesis GO:0014014 3 0.203
regulation of neuron differentiation GO:0045664 70 0.200
peptidyl threonine phosphorylation GO:0018107 41 0.199
Human
potassium ion transmembrane transport GO:0071805 60 0.197
somatic stem cell maintenance GO:0035019 4 0.196
Fly
pituitary gland development GO:0021983 2 0.195
positive regulation of immune response GO:0050778 159 0.194
gonad development GO:0008406 34 0.193
cellular amino acid metabolic process GO:0006520 116 0.190
regulation of transmembrane transporter activity GO:0022898 74 0.186
regulation of cell morphogenesis GO:0022604 153 0.185
Human
single organism cellular localization GO:1902580 332 0.182
Human
response to wounding GO:0009611 168 0.181
extrinsic apoptotic signaling pathway GO:0097191 119 0.180
Human
regulation of epithelial cell proliferation GO:0050678 113 0.179
cell proliferation involved in heart valve development GO:2000793 1 0.176
blastoderm segmentation GO:0007350 2 0.176
Fly
positive regulation of protein ubiquitination GO:0031398 53 0.176
Human
protein targeting to nucleus GO:0044744 104 0.175
Human
protein import GO:0017038 130 0.175
Human
negative regulation of protein ubiquitination GO:0031397 35 0.173
Human
regulation of cell development GO:0060284 161 0.172
Human
regulation of protein targeting GO:1903533 91 0.169
Human
sodium ion transport GO:0006814 61 0.167
adherens junction assembly GO:0034333 34 0.166
Human
regulation of protein localization to nucleus GO:1900180 85 0.166
Human
positive regulation of mapk cascade GO:0043410 190 0.164
single organismal cell cell adhesion GO:0016337 148 0.161
Human
regulation of cell differentiation GO:0045595 393 0.157
Human Mouse Fly
mapk cascade GO:0000165 288 0.157
regulation of peptidyl serine phosphorylation GO:0033135 50 0.154
Human
neuron development GO:0048666 113 0.154
regulation of locomotion GO:0040012 329 0.151
stem cell maintenance GO:0019827 19 0.148
Fly
positive regulation of peptidase activity GO:0010952 88 0.148
Human
cation transmembrane transport GO:0098655 238 0.148
regulation of cytoplasmic transport GO:1903649 149 0.148
Human
regulation of endothelial cell migration GO:0010594 67 0.147
stem cell differentiation GO:0048863 93 0.146
Human Fly
ion transmembrane transport GO:0034220 338 0.146
negative regulation of protein modification process GO:0031400 200 0.145
Human
peptidyl serine modification GO:0018209 106 0.144
Human
cell development GO:0048468 328 0.143
Human Mouse Fly
immune response GO:0006955 307 0.142
Human
rna processing GO:0006396 255 0.141
transmission of virus GO:0019089 1 0.141
cell part morphogenesis GO:0032990 137 0.141
positive regulation of cellular component organization GO:0051130 376 0.139
Human Fly
tube morphogenesis GO:0035239 95 0.138
Zebrafish Fly
negative regulation of cell death GO:0060548 345 0.138
Human
positive regulation of cell differentiation GO:0045597 211 0.138
Human Mouse
positive regulation of mesenchymal stem cell differentiation GO:2000741 4 0.137
negative regulation of peptidyl threonine phosphorylation GO:0010801 6 0.136
Human
regulation of wnt signaling pathway GO:0030111 123 0.135
Human
mesenchyme development GO:0060485 59 0.135
Human
positive regulation of nucleoside metabolic process GO:0045979 186 0.132
system process GO:0003008 349 0.131
Mouse
nuclear import GO:0051170 106 0.131
Human
regulation of endopeptidase activity GO:0052548 170 0.131
Human
mesonephric epithelium development GO:0072163 14 0.130
Mouse
cellular potassium ion transport GO:0071804 60 0.130
bone development GO:0060348 26 0.130
Mouse
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.129
positive regulation of programmed cell death GO:0043068 249 0.129
Human
negative regulation of catalytic activity GO:0043086 335 0.129
Human
coenzyme metabolic process GO:0006732 65 0.127
positive regulation of epithelial to mesenchymal transition GO:0010718 22 0.125
Human
regulation of cytokine production GO:0001817 232 0.125
Human
regulation of cell cell adhesion GO:0022407 57 0.122
Human
positive regulation of cell cell adhesion GO:0022409 22 0.122
Human
lipid metabolic process GO:0006629 381 0.120
mesenchymal cell differentiation GO:0048762 52 0.119
Human
angiogenesis GO:0001525 147 0.117
sex differentiation GO:0007548 45 0.116
Worm
midbrain development GO:0030901 45 0.114
chemical homeostasis GO:0048878 306 0.114
protein targeting GO:0006605 187 0.114
Human
defense response to other organism GO:0098542 129 0.112
sex determination GO:0007530 3 0.112
smad protein signal transduction GO:0060395 10 0.112
Human
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.110
Fly
positive regulation of intracellular protein transport GO:0090316 76 0.108
Human
regulation of cysteine type endopeptidase activity GO:2000116 127 0.107
Human
morphogenesis of an epithelium GO:0002009 60 0.107
Zebrafish Fly
response to sterol GO:0036314 14 0.106
Human
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.105
blood vessel morphogenesis GO:0048514 162 0.105
Zebrafish
regulation of glial cell proliferation GO:0060251 4 0.101
positive regulation of cell adhesion GO:0045785 84 0.099
Human
negative regulation of peptidyl serine phosphorylation GO:0033137 8 0.098
Human
stem cell division GO:0017145 2 0.098
Fly
progesterone receptor signaling pathway GO:0050847 3 0.098
regulation of ubiquitin protein transferase activity GO:0051438 28 0.096
Human
protein complex localization GO:0031503 31 0.096
Human
cofactor metabolic process GO:0051186 87 0.094
modification by symbiont of host morphology or physiology GO:0044003 12 0.094
Human
nodal signaling pathway GO:0038092 5 0.093
Human
regulation of potassium ion transmembrane transport GO:1901379 20 0.093
response to organic cyclic compound GO:0014070 204 0.091
Human Mouse
regulation of transforming growth factor beta2 production GO:0032909 6 0.091
Human
regulation of protein ubiquitination GO:0031396 95 0.090
Human
protein localization to nucleus GO:0034504 136 0.089
Human
reproduction GO:0000003 63 0.089
Mouse Worm Fly
response to bmp GO:0071772 8 0.087
Mouse
positive regulation of protein phosphorylation GO:0001934 313 0.085
negative regulation of transcription by competitive promoter binding GO:0010944 8 0.084
Human
regulation of transferase activity GO:0051338 355 0.084
Human
regulation of ossification GO:0030278 58 0.084
Mouse
modification of morphology or physiology of other organism GO:0035821 43 0.083
Human
stress activated mapk cascade GO:0051403 93 0.082
neuron projection development GO:0031175 106 0.082
transmembrane transport GO:0055085 399 0.081
determination of bilateral symmetry GO:0009855 15 0.080
Human Zebrafish
negative regulation of neurogenesis GO:0050768 26 0.080
regulation of cellular amino acid metabolic process GO:0006521 6 0.080
heart development GO:0007507 95 0.080
Zebrafish
regulation of sodium ion transport GO:0002028 24 0.080
single organism cell adhesion GO:0098602 179 0.080
Human
regulation of muscle organ development GO:0048634 27 0.079
isoprenoid biosynthetic process GO:0008299 9 0.078
protein stabilization GO:0050821 64 0.078
Human
negative regulation of cell development GO:0010721 48 0.077
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.075
Human
cell cell junction organization GO:0045216 69 0.074
Human
generation of neurons GO:0048699 152 0.074
regulation of muscle system process GO:0090257 53 0.073
rna splicing via transesterification reactions GO:0000375 90 0.073
central nervous system development GO:0007417 123 0.073
mitotic cell cycle process GO:1903047 286 0.072
Fly
regulation of immune response GO:0050776 201 0.072
positive regulation of map kinase activity GO:0043406 80 0.071
positive regulation of cell development GO:0010720 92 0.070
Human
regulation of membrane potential GO:0042391 95 0.070
determination of left right symmetry GO:0007368 11 0.069
Human Zebrafish
response to biotic stimulus GO:0009607 276 0.068
Human
epithelial cell proliferation GO:0050673 128 0.068
negative regulation of cell cycle process GO:0010948 121 0.068
Fly
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.067
Human
negative regulation of developmental process GO:0051093 247 0.067
Fly
heart morphogenesis GO:0003007 48 0.067
Zebrafish
regulation of transforming growth factor beta production GO:0071634 13 0.067
Human
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 38 0.067
Human
negative regulation of catabolic process GO:0009895 104 0.067
Human
cell junction organization GO:0034330 79 0.067
Human
development of primary sexual characteristics GO:0045137 35 0.066
i kappab kinase nf kappab signaling GO:0007249 166 0.065
actin filament based process GO:0030029 224 0.065
positive regulation of protein catabolic process GO:0045732 75 0.062
Human
nuclear export GO:0051168 69 0.061
negative regulation of programmed cell death GO:0043069 321 0.060
Human
fat cell differentiation GO:0045444 32 0.060
Human
regulation of cell migration GO:0030334 289 0.059
regulation of neuron projection development GO:0010975 57 0.059
positive regulation of chondrocyte differentiation GO:0032332 4 0.058
innate immune response GO:0045087 178 0.058
regulation of transmembrane transport GO:0034762 139 0.058
regulation of mapk cascade GO:0043408 262 0.058
organelle localization GO:0051640 84 0.057
positive regulation of endopeptidase activity GO:0010950 84 0.057
Human
regulation of male gonad development GO:2000018 4 0.057
protein processing GO:0016485 226 0.057
Human
heart process GO:0003015 62 0.056
Mouse
positive regulation of catenin import into nucleus GO:0035413 9 0.056
Human
negative regulation of ligase activity GO:0051352 8 0.054
Human
regulation of sodium ion transmembrane transport GO:1902305 23 0.054
natural killer cell activation GO:0030101 12 0.054
protein autophosphorylation GO:0046777 123 0.054
wound healing GO:0042060 115 0.053
negative regulation of protein transport GO:0051224 75 0.053
ribosomal subunit export from nucleus GO:0000054 4 0.053
embryonic epithelial tube formation GO:0001838 4 0.053
activation of immune response GO:0002253 114 0.053
specification of symmetry GO:0009799 16 0.052
Human Zebrafish
membrane repolarization GO:0086009 23 0.050
cation transport GO:0006812 331 0.050
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 1 0.050
Human
meiotic chromosome segregation GO:0045132 4 0.050
response to alcohol GO:0097305 64 0.050
Human
regulation of developmental growth GO:0048638 30 0.050
Worm Fly
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.050
biological adhesion GO:0022610 331 0.049
Human
positive regulation of transferase activity GO:0051347 227 0.049
peptidyl lysine acetylation GO:0018394 101 0.049
positive regulation of nucleotide catabolic process GO:0030813 185 0.049
ossification GO:0001503 121 0.049
Mouse
neuron projection morphogenesis GO:0048812 50 0.049
regulation of fatty acid metabolic process GO:0019217 24 0.049
regulation of neurogenesis GO:0050767 82 0.048
positive regulation of jnk cascade GO:0046330 52 0.048
regulation of chondrocyte differentiation GO:0032330 9 0.048
signal transduction in response to dna damage GO:0042770 57 0.048
catenin import into nucleus GO:0035411 18 0.047
Human
regulation of protein stability GO:0031647 87 0.047
Human
cardiovascular system development GO:0072358 262 0.047
Zebrafish
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.047
oxidoreduction coenzyme metabolic process GO:0006733 19 0.046
posttranscriptional regulation of gene expression GO:0010608 213 0.045
Human
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.045
Fly
oogenesis GO:0048477 2 0.045
Fly
mitochondrion organization GO:0007005 156 0.045
response to abiotic stimulus GO:0009628 336 0.045
Human
axon development GO:0061564 34 0.044
positive regulation of protein transport GO:0051222 135 0.044
Human
spermatid differentiation GO:0048515 4 0.044
regulation of transporter activity GO:0032409 82 0.043
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.043
Fly
epithelium migration GO:0090132 119 0.043
ubiquitin dependent smad protein catabolic process GO:0030579 4 0.043
dephosphorylation GO:0016311 209 0.043
regulation of multi organism process GO:0043900 157 0.042
digestive tract morphogenesis GO:0048546 56 0.042
Zebrafish Fly
response to decreased oxygen levels GO:0036293 96 0.042
Human
vacuolar transport GO:0007034 34 0.042
mesodermal cell fate specification GO:0007501 2 0.042
positive regulation of epithelial cell proliferation GO:0050679 65 0.042
negative regulation of ion transmembrane transporter activity GO:0032413 19 0.041
positive regulation of cell motility GO:2000147 177 0.041
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.041
Human
cell division GO:0051301 168 0.040
Fly
isoprenoid metabolic process GO:0006720 39 0.040
regulation of cell growth GO:0001558 135 0.040
Human
protein oligomerization GO:0051259 173 0.040
single organism reproductive process GO:0044702 98 0.040
Mouse Fly
immune response activating signal transduction GO:0002757 90 0.040
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.040
Human
developmental process involved in reproduction GO:0003006 66 0.039
Mouse Worm Fly
anterior posterior axis specification GO:0009948 2 0.039
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 22 0.039
apoptotic signaling pathway GO:0097190 268 0.039
Human
negative regulation of ion transmembrane transport GO:0034766 26 0.038
cell fate commitment GO:0045165 27 0.038
Mouse Fly
response to inorganic substance GO:0010035 127 0.037
reproductive structure development GO:0048608 55 0.037
positive regulation of apoptotic process GO:0043065 246 0.037
Human
zymogen activation GO:0031638 70 0.037
Human
epithelial to mesenchymal transition GO:0001837 48 0.037
Human
ureteric bud development GO:0001657 13 0.036
Mouse
response to hypoxia GO:0001666 96 0.036
Human
organophosphate catabolic process GO:0046434 430 0.036
positive regulation of locomotion GO:0040017 186 0.036
negative regulation of cell cycle phase transition GO:1901988 89 0.036
Fly
negative regulation of cellular component organization GO:0051129 235 0.036
Human
positive regulation of cellular component biogenesis GO:0044089 158 0.036
Fly
female gamete generation GO:0007292 2 0.036
Fly
cell type specific apoptotic process GO:0097285 125 0.036
rho protein signal transduction GO:0007266 26 0.035
tissue migration GO:0090130 119 0.035
regulation of ion transmembrane transport GO:0034765 132 0.035
regulation of cell cycle arrest GO:0071156 36 0.035
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 10 0.034
response to cholesterol GO:0070723 11 0.034
Human
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.034
Human
positive regulation of protein kinase activity GO:0045860 190 0.034
mrna splicing via spliceosome GO:0000398 89 0.034
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.034
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.033
regulation of catenin import into nucleus GO:0035412 18 0.033
Human
activation of cysteine type endopeptidase activity GO:0097202 57 0.033
Human
gland development GO:0048732 48 0.033
cell projection morphogenesis GO:0048858 129 0.033
positive regulation of cytokine production GO:0001819 167 0.033
urogenital system development GO:0001655 65 0.032
Mouse Fly
cell growth GO:0016049 160 0.032
Human
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.032
cell junction assembly GO:0034329 67 0.031
Human
muscle structure development GO:0061061 98 0.031
establishment of organelle localization GO:0051656 59 0.031
regulation of potassium ion transmembrane transporter activity GO:1901016 16 0.031
negative regulation of protein catabolic process GO:0042177 59 0.031
Human
pattern specification process GO:0007389 43 0.030
Human Zebrafish Fly
regulation of ion transmembrane transporter activity GO:0032412 72 0.030
regulation of metal ion transport GO:0010959 120 0.030
negative regulation of multicellular organismal process GO:0051241 317 0.030
cellular macromolecular complex assembly GO:0034622 324 0.030
Human
negative regulation of defense response GO:0031348 47 0.030
rna splicing GO:0008380 131 0.029
regulation of peptidase activity GO:0052547 180 0.029
Human
regulation of cell projection organization GO:0031344 107 0.029
n terminal protein amino acid modification GO:0031365 13 0.029
muscle contraction GO:0006936 73 0.029
Mouse
circulatory system development GO:0072359 262 0.029
Zebrafish

SMAD5 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.236
Human
disease of cellular proliferation DOID:14566 174 0.236
Human
organ system cancer DOID:0050686 164 0.106
Human
gastrointestinal system cancer DOID:3119 52 0.031
Human