|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.837
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.796
|
Human Fly |
|
|
response to growth factor
|
GO:0070848 |
205 |
0.748
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.746
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
49 |
0.745
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.699
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.694
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.678
|
Human |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.674
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.666
|
Human |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.657
|
|
|
|
positive regulation of stem cell differentiation
|
GO:2000738 |
29 |
0.632
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.623
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.621
|
Fly |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.593
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.576
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.572
|
Human Fly |
|
|
mesenchymal cell differentiation
|
GO:0048762 |
52 |
0.554
|
Human |
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.552
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.547
|
Fly |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.534
|
|
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.533
|
Human |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.531
|
Human |
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.522
|
Fly |
|
|
skeletal system development
|
GO:0001501 |
79 |
0.508
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.505
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.501
|
Human |
|
|
positive regulation of transcription from rna polymerase ii promoter involved in myocardial precursor cell differentiation
|
GO:0003257 |
3 |
0.500
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.495
|
Fly |
|
|
stem cell development
|
GO:0048864 |
69 |
0.479
|
Human Fly |
|
|
circulatory system development
|
GO:0072359 |
262 |
0.474
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.471
|
Human Fly |
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.471
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.469
|
Human |
|
|
epithelium development
|
GO:0060429 |
227 |
0.469
|
Mouse Fly |
|
|
regulation of pathway restricted smad protein phosphorylation
|
GO:0060393 |
34 |
0.464
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.461
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.460
|
Human |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.445
|
|
|
|
heart morphogenesis
|
GO:0003007 |
48 |
0.437
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.436
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.432
|
Human |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.425
|
Fly |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.419
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.404
|
Human |
|
|
activin receptor signaling pathway
|
GO:0032924 |
24 |
0.371
|
Human |
|
|
heart development
|
GO:0007507 |
95 |
0.367
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.365
|
|
|
|
endocrine system development
|
GO:0035270 |
26 |
0.359
|
|
|
|
regulation of ketone biosynthetic process
|
GO:0010566 |
7 |
0.352
|
|
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.349
|
Human |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.346
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus
|
GO:1901522 |
2 |
0.343
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.343
|
Mouse Fly |
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.323
|
Human |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.322
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.322
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.321
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.305
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.303
|
Human Fly |
|
|
retinal ganglion cell axon guidance
|
GO:0031290 |
2 |
0.300
|
Fly |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.299
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.288
|
Human |
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.284
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.284
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.280
|
|
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
48 |
0.280
|
Human |
|
|
negative regulation of cellular component movement
|
GO:0051271 |
106 |
0.280
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.275
|
Fly |
|
|
endodermal cell fate commitment
|
GO:0001711 |
4 |
0.272
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.271
|
Human Fly |
|
|
mesenchymal cell development
|
GO:0014031 |
50 |
0.262
|
Human |
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.262
|
Fly |
|
|
common partner smad protein phosphorylation
|
GO:0007182 |
3 |
0.260
|
Human |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.258
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.254
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.253
|
Human |
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.250
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.243
|
Human |
|
|
positive regulation of epithelial to mesenchymal transition
|
GO:0010718 |
22 |
0.237
|
Human |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.234
|
Human |
|
|
regulation of mesoderm development
|
GO:2000380 |
4 |
0.232
|
Human |
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.231
|
Human |
|
|
regulation of activin receptor signaling pathway
|
GO:0032925 |
14 |
0.230
|
Human |
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
37 |
0.228
|
Human |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.228
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.222
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.221
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.217
|
Human |
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.217
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.215
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.214
|
Fly |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.211
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.211
|
Human |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.198
|
Human |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.198
|
Human |
|
|
angiogenesis
|
GO:0001525 |
147 |
0.197
|
|
|
|
negative regulation of monocyte differentiation
|
GO:0045656 |
3 |
0.194
|
|
|
|
canonical wnt signaling pathway
|
GO:0060070 |
116 |
0.194
|
Human |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.192
|
Human |
|
|
epithelial cell differentiation
|
GO:0030855 |
141 |
0.192
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.191
|
Human |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.188
|
Human |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.187
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.186
|
Worm Fly |
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.184
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.183
|
Fly |
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.183
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.182
|
Fly |
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.178
|
Fly |
|
|
formation of primary germ layer
|
GO:0001704 |
42 |
0.178
|
|
|
|
evasion or tolerance of host defenses by virus
|
GO:0019049 |
2 |
0.177
|
Human |
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.175
|
|
|
|
regulation of canonical wnt signaling pathway
|
GO:0060828 |
88 |
0.173
|
Human |
|
|
pattern specification process
|
GO:0007389 |
43 |
0.172
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.172
|
Fly |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.170
|
|
|
|
interaction with host
|
GO:0051701 |
42 |
0.169
|
Human |
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.164
|
|
|
|
regulation of muscle organ development
|
GO:0048634 |
27 |
0.160
|
Fly |
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.159
|
Human |
|
|
renal system development
|
GO:0072001 |
63 |
0.158
|
Mouse Fly |
|
|
positive regulation of canonical wnt signaling pathway
|
GO:0090263 |
33 |
0.157
|
Human |
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.156
|
Human |
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.156
|
Human |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.156
|
Human |
|
|
positive regulation of pathway restricted smad protein phosphorylation
|
GO:0010862 |
22 |
0.155
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.155
|
Fly |
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.153
|
Human |
|
|
neuron development
|
GO:0048666 |
113 |
0.152
|
Fly |
|
|
response to wounding
|
GO:0009611 |
168 |
0.151
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.150
|
Human Fly |
|
|
endodermal cell fate specification
|
GO:0001714 |
4 |
0.149
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.149
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.147
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.146
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.145
|
Fly |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.145
|
|
|
|
positive regulation of osteoblast differentiation
|
GO:0045669 |
23 |
0.145
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.144
|
|
|
|
pathway restricted smad protein phosphorylation
|
GO:0060389 |
38 |
0.142
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.142
|
Human |
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.142
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.141
|
Fly |
|
|
avoidance of defenses of other organism involved in symbiotic interaction
|
GO:0051832 |
2 |
0.140
|
Human |
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.140
|
Human Fly |
|
|
response to host
|
GO:0075136 |
2 |
0.140
|
Human |
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.139
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.139
|
Human |
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.139
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.138
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.138
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.137
|
Fly |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.137
|
Human |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.137
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.136
|
Human |
|
|
segmentation
|
GO:0035282 |
4 |
0.136
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.134
|
Human |
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.134
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.133
|
Human |
|
|
kidney development
|
GO:0001822 |
53 |
0.131
|
Mouse |
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.130
|
Human |
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.130
|
Human |
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.130
|
Human |
|
|
regulation of bmp signaling pathway
|
GO:0030510 |
27 |
0.130
|
|
|
|
viral process
|
GO:0016032 |
146 |
0.129
|
Human |
|
|
hard palate development
|
GO:0060022 |
1 |
0.129
|
|
|
|
positive regulation of bmp signaling pathway
|
GO:0030513 |
9 |
0.129
|
Human |
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.129
|
Human |
|
|
oogenesis
|
GO:0048477 |
2 |
0.129
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.127
|
Human |
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.127
|
Human |
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.126
|
Human |
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.126
|
|
|
|
cardiac chamber development
|
GO:0003205 |
30 |
0.125
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.124
|
|
|
|
isoprenoid metabolic process
|
GO:0006720 |
39 |
0.124
|
|
|
|
positive regulation of lipid biosynthetic process
|
GO:0046889 |
22 |
0.124
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.123
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.121
|
|
|
|
receptor catabolic process
|
GO:0032801 |
11 |
0.121
|
|
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
54 |
0.121
|
Human |
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.120
|
Fly |
|
|
evasion or tolerance of host defenses
|
GO:0044415 |
2 |
0.120
|
Human |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.120
|
|
|
|
mesonephros development
|
GO:0001823 |
17 |
0.118
|
Mouse |
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.117
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.117
|
Human |
|
|
positive regulation of cell adhesion
|
GO:0045785 |
84 |
0.117
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.116
|
Human |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.116
|
|
|
|
sex determination
|
GO:0007530 |
3 |
0.116
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.114
|
|
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
38 |
0.114
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.114
|
Human |
|
|
organ formation
|
GO:0048645 |
3 |
0.113
|
|
|
|
kidney epithelium development
|
GO:0072073 |
25 |
0.112
|
Mouse |
|
|
somatic stem cell maintenance
|
GO:0035019 |
4 |
0.112
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.111
|
Human |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.110
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.109
|
Fly |
|
|
protein import
|
GO:0017038 |
130 |
0.109
|
Human |
|
|
immune system development
|
GO:0002520 |
195 |
0.109
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.107
|
Human |
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.107
|
Human |
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.107
|
Human |
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
48 |
0.106
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.105
|
Human |
|
|
mesonephric tubule development
|
GO:0072164 |
14 |
0.105
|
Mouse |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.104
|
Human |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.103
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.103
|
Human |
|
|
chemotaxis
|
GO:0006935 |
157 |
0.103
|
Fly |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.102
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.102
|
|
|
|
positive regulation of mesenchymal cell proliferation
|
GO:0002053 |
2 |
0.101
|
|
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.099
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.099
|
|
|
|
lateral mesoderm development
|
GO:0048368 |
1 |
0.099
|
Human |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.098
|
|
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.098
|
|
|
|
negative regulation of pathway restricted smad protein phosphorylation
|
GO:0060394 |
11 |
0.097
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.097
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.097
|
Human |
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.097
|
Human |
|
|
response to other organism
|
GO:0051707 |
261 |
0.096
|
Human |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.094
|
Human |
|
|
female gamete generation
|
GO:0007292 |
2 |
0.094
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.093
|
|
|
|
positive regulation of ossification
|
GO:0045778 |
32 |
0.093
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.092
|
|
|
|
positive regulation of cell morphogenesis involved in differentiation
|
GO:0010770 |
50 |
0.091
|
Human |
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.091
|
Human |
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.091
|
Human |
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.090
|
Human |
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.090
|
|
|
|
positive regulation of aldosterone metabolic process
|
GO:0032346 |
2 |
0.090
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.089
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.089
|
Human |
|
|
muscle structure development
|
GO:0061061 |
98 |
0.088
|
Fly |
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.087
|
Human |
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.086
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.086
|
|
|
|
cardiac chamber morphogenesis
|
GO:0003206 |
26 |
0.085
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.085
|
Human |
|
|
muscle contraction
|
GO:0006936 |
73 |
0.084
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.084
|
Human |
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.084
|
Fly |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.084
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.084
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.083
|
Human |
|
|
embryo development
|
GO:0009790 |
123 |
0.083
|
|
|
|
mesonephric epithelium development
|
GO:0072163 |
14 |
0.083
|
Mouse |
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.082
|
|
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.082
|
Human |
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.082
|
Human |
|
|
negative regulation of cellular response to growth factor stimulus
|
GO:0090288 |
41 |
0.081
|
|
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.081
|
Human |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.081
|
|
|
|
adherens junction organization
|
GO:0034332 |
36 |
0.080
|
Human |
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.079
|
Human |
|
|
cardiac septum morphogenesis
|
GO:0060411 |
9 |
0.078
|
|
|
|
regionalization
|
GO:0003002 |
29 |
0.078
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.078
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.078
|
Human |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.077
|
Human |
|
|
cytokine production
|
GO:0001816 |
247 |
0.076
|
Human |
|
|
gastrulation
|
GO:0007369 |
51 |
0.076
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.076
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.076
|
Human |
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.076
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.076
|
Fly |
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.075
|
Human |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.075
|
|
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
45 |
0.074
|
|
|
|
negative regulation of bmp signaling pathway
|
GO:0030514 |
17 |
0.074
|
|
|
|
response to cholesterol
|
GO:0070723 |
11 |
0.074
|
Human |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.074
|
Human |
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.073
|
|
|
|
regulation of cell substrate adhesion
|
GO:0010810 |
68 |
0.073
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.072
|
Fly |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.072
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.072
|
Human |
|
|
cardiac muscle cell fate commitment
|
GO:0060923 |
4 |
0.072
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.072
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.072
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.071
|
Human Fly |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.071
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.071
|
Human |
|
|
cell activation
|
GO:0001775 |
213 |
0.070
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.070
|
Human |
|
|
immune response
|
GO:0006955 |
307 |
0.070
|
|
|
|
positive regulation of cell cell adhesion
|
GO:0022409 |
22 |
0.070
|
Human |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.069
|
Human |
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.069
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.068
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.068
|
Human |
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.068
|
|
|
|
positive regulation of aldosterone biosynthetic process
|
GO:0032349 |
2 |
0.068
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.068
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.067
|
|
|
|
negative regulation of transforming growth factor beta receptor signaling pathway
|
GO:0030512 |
28 |
0.067
|
|
|
|
muscle system process
|
GO:0003012 |
81 |
0.066
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.066
|
Human |
|
|
regulation of catenin import into nucleus
|
GO:0035412 |
18 |
0.066
|
Human |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.066
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.066
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.066
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.065
|
|
|
|
tissue migration
|
GO:0090130 |
119 |
0.065
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.065
|
|
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.065
|
Human |
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.064
|
Human |
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.064
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.064
|
|
|
|
regulation of muscle system process
|
GO:0090257 |
53 |
0.064
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.063
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.063
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.063
|
Human |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.063
|
|
|
|
cell fate commitment involved in formation of primary germ layer
|
GO:0060795 |
6 |
0.063
|
|
|
|
response to host defenses
|
GO:0052200 |
2 |
0.063
|
Human |
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.063
|
Human |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.062
|
Human |
|
|
ossification
|
GO:0001503 |
121 |
0.062
|
|
|
|
appendage morphogenesis
|
GO:0035107 |
16 |
0.062
|
Fly |
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.062
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.061
|
|
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.061
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.061
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.060
|
|
|
|
head development
|
GO:0060322 |
108 |
0.060
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.060
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.060
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.059
|
Human |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.059
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.059
|
|
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.059
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.059
|
|
|
|
modulation by virus of host morphology or physiology
|
GO:0019048 |
10 |
0.059
|
Human |
|
|
system process
|
GO:0003008 |
349 |
0.059
|
|
|
|
negative regulation of muscle organ development
|
GO:0048635 |
12 |
0.058
|
Fly |
|
|
cell junction assembly
|
GO:0034329 |
67 |
0.058
|
Human |
|
|
zymogen activation
|
GO:0031638 |
70 |
0.058
|
Human |
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.057
|
Human |
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.057
|
|
|
|
forebrain regionalization
|
GO:0021871 |
3 |
0.057
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.057
|
Human |
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.057
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.056
|
|
|
|
atrioventricular valve development
|
GO:0003171 |
3 |
0.056
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.056
|
Human |
|
|
determination of left right asymmetry in lateral mesoderm
|
GO:0003140 |
1 |
0.056
|
Human |
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.055
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.055
|
Human |
|
|
urogenital system development
|
GO:0001655 |
65 |
0.055
|
Mouse Fly |
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.055
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.055
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.055
|
|
|
|
negative regulation of gliogenesis
|
GO:0014014 |
3 |
0.054
|
|
|
|
transforming growth factor beta production
|
GO:0071604 |
14 |
0.054
|
Human |
|
|
cell proliferation involved in heart valve development
|
GO:2000793 |
1 |
0.054
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.054
|
Human |
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.054
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.054
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.054
|
|
|
|
cell cycle phase transition
|
GO:0044770 |
173 |
0.053
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.053
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.053
|
|
|
|
endocardial cushion development
|
GO:0003197 |
3 |
0.053
|
|
|
|
adherens junction assembly
|
GO:0034333 |
34 |
0.052
|
Human |
|
|
striated muscle contraction
|
GO:0006941 |
52 |
0.052
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.052
|
Human |
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.052
|
Human |
|
|
nuclear division
|
GO:0000280 |
128 |
0.052
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.052
|
Human |
|
|
anterior posterior axis specification
|
GO:0009948 |
2 |
0.052
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.052
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.052
|
Human |
|
|
response to alcohol
|
GO:0097305 |
64 |
0.051
|
Human |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.051
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.050
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.050
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.050
|
|
|
|
endoderm formation
|
GO:0001706 |
33 |
0.050
|
|
|
|
regulation of cell matrix adhesion
|
GO:0001952 |
42 |
0.050
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.050
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.050
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.049
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.049
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.049
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.049
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.049
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.048
|
|
|
|
endodermal cell differentiation
|
GO:0035987 |
31 |
0.048
|
|
|
|
endoderm development
|
GO:0007492 |
33 |
0.048
|
|
|
|
positive regulation of purine nucleotide catabolic process
|
GO:0033123 |
185 |
0.048
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
41 |
0.048
|
Human |
|
|
bone development
|
GO:0060348 |
26 |
0.048
|
|
|
|
epithelium migration
|
GO:0090132 |
119 |
0.048
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.048
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.048
|
|
|
|
biomineral tissue development
|
GO:0031214 |
39 |
0.047
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.047
|
Human |
|
|
hindbrain development
|
GO:0030902 |
3 |
0.047
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.047
|
|
|
|
cardiac septum development
|
GO:0003279 |
13 |
0.046
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.046
|
|
|
|
regulation of smad protein import into nucleus
|
GO:0060390 |
10 |
0.046
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.045
|
Human |
|
|
chromatin organization
|
GO:0006325 |
351 |
0.045
|
|
|
|
regulation of cartilage development
|
GO:0061035 |
12 |
0.045
|
|
|
|
growth
|
GO:0040007 |
202 |
0.045
|
Human Fly |
|
|
negative regulation of peptidyl threonine phosphorylation
|
GO:0010801 |
6 |
0.045
|
Human |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.045
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.045
|
Human |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.045
|
|
|
|
response to oxygen levels
|
GO:0070482 |
100 |
0.044
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.044
|
Human |
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
50 |
0.044
|
Human |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.044
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.044
|
Human |
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.044
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.044
|
|
|
|
myeloid cell homeostasis
|
GO:0002262 |
34 |
0.044
|
|
|
|
regulation of cardiac muscle contraction
|
GO:0055117 |
33 |
0.044
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.043
|
Fly |
|
|
negative regulation of sodium ion transmembrane transport
|
GO:1902306 |
2 |
0.043
|
|
|
|
positive regulation of transcription from rna polymerase ii promoter involved in heart development
|
GO:1901228 |
3 |
0.043
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.043
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.043
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.042
|
|
|
|
stem cell division
|
GO:0017145 |
2 |
0.042
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.042
|
|
|
|
mesoderm development
|
GO:0007498 |
14 |
0.042
|
Human |
|
|
forelimb morphogenesis
|
GO:0035136 |
4 |
0.042
|
|
|
|
circulatory system process
|
GO:0003013 |
113 |
0.042
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.042
|
Human |
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.042
|
Human |
|
|
muscle cell fate commitment
|
GO:0042693 |
4 |
0.042
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.042
|
Human |
|
|
endochondral bone morphogenesis
|
GO:0060350 |
3 |
0.042
|
|
|
|
cardiac ventricle development
|
GO:0003231 |
23 |
0.042
|
|
|
|
negative regulation of cell development
|
GO:0010721 |
48 |
0.042
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.041
|
Human |
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.041
|
|
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.041
|
Human |
|
|
cell fate determination
|
GO:0001709 |
3 |
0.041
|
|
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.041
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.040
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.040
|
Human |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.040
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.040
|
Fly |
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.040
|
Human |
|
|
cell fate commitment
|
GO:0045165 |
27 |
0.040
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.040
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
2 |
0.040
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.039
|
Human |
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.039
|
|
|
|
positive regulation of hormone biosynthetic process
|
GO:0046886 |
4 |
0.039
|
|
|
|
smad protein complex assembly
|
GO:0007183 |
12 |
0.039
|
|
|
|
positive regulation of steroid hormone biosynthetic process
|
GO:0090031 |
2 |
0.039
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.039
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.039
|
Human |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.039
|
Human |
|
|
hematopoietic stem cell differentiation
|
GO:0060218 |
4 |
0.038
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.038
|
|
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.038
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.038
|
|
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.037
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.037
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.037
|
|
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.037
|
Human Fly |
|
|
regulation of mrna export from nucleus
|
GO:0010793 |
3 |
0.037
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.037
|
|
|
|
coenzyme metabolic process
|
GO:0006732 |
65 |
0.036
|
|
|
|
g1 s transition of mitotic cell cycle
|
GO:0000082 |
78 |
0.036
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.036
|
|
|
|
cardiac ventricle morphogenesis
|
GO:0003208 |
20 |
0.036
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.036
|
Human |
|
|
cell cycle g1 s phase transition
|
GO:0044843 |
80 |
0.036
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.036
|
|
|
|
pericardium development
|
GO:0060039 |
2 |
0.036
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.036
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.036
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.036
|
|
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.036
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.035
|
|
|
|
cardiac right ventricle morphogenesis
|
GO:0003215 |
3 |
0.035
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.035
|
|
|
|
cellular response to bmp stimulus
|
GO:0071773 |
8 |
0.035
|
|
