Homo sapiens

42 known processes

SMC6

structural maintenance of chromosomes 6

(Aliases: SMC6L1,FLJ35534,SMC-6,FLJ22116,hSMC6)

SMC6 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sister chromatid segregation GO:0000819 54 0.959
cellular response to dna damage stimulus GO:0006974 379 0.950
Yeast Fly
double strand break repair via homologous recombination GO:0000724 50 0.911
Yeast
double strand break repair GO:0006302 101 0.888
Yeast
cell cycle phase transition GO:0044770 173 0.871
organelle fission GO:0048285 149 0.852
mitotic nuclear division GO:0007067 119 0.821
metaphase anaphase transition of cell cycle GO:0044784 21 0.808
mitotic cell cycle process GO:1903047 286 0.801
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.784
cell aging GO:0007569 52 0.754
mitotic cell cycle phase transition GO:0044772 162 0.753
cellular senescence GO:0090398 34 0.748
regulation of cell cycle phase transition GO:1901987 126 0.706
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.687
regulation of chromosome organization GO:0033044 103 0.649
regulation of cellular protein catabolic process GO:1903362 96 0.622
chromosome separation GO:0051304 23 0.605
Yeast
cellular macromolecule catabolic process GO:0044265 380 0.581
mitotic sister chromatid segregation GO:0000070 53 0.576
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.570
regulation of cell cycle GO:0051726 393 0.554
mitotic sister chromatid separation GO:0051306 18 0.523
mitotic cell cycle GO:0000278 326 0.516
nuclear division GO:0000280 128 0.489
regulation of mitotic sister chromatid segregation GO:0033047 27 0.473
chromosome segregation GO:0007059 114 0.465
Yeast
regulation of proteolysis GO:0030162 293 0.433
regulation of response to dna damage stimulus GO:2001020 94 0.422
regulation of cellular response to stress GO:0080135 244 0.410
microtubule based process GO:0007017 210 0.409
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.405
sister chromatid cohesion GO:0007062 24 0.384
dna recombination GO:0006310 77 0.379
microtubule cytoskeleton organization GO:0000226 176 0.378
telomere organization GO:0032200 33 0.365
regulation of mitosis GO:0007088 63 0.361
regulation of mitotic cell cycle GO:0007346 189 0.347
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.332
dna repair GO:0006281 198 0.311
Yeast
regulation of mitotic cell cycle phase transition GO:1901990 118 0.299
positive regulation of protein catabolic process GO:0045732 75 0.294
cellular protein catabolic process GO:0044257 261 0.287
positive regulation of mitosis GO:0045840 25 0.277
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.248
positive regulation of cellular component organization GO:0051130 376 0.246
cell division GO:0051301 168 0.233
regulation of protein catabolic process GO:0042176 155 0.227
organelle assembly GO:0070925 176 0.218
negative regulation of protein metabolic process GO:0051248 391 0.203
negative regulation of cellular protein metabolic process GO:0032269 353 0.202
positive regulation of cellular catabolic process GO:0031331 284 0.200
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.183
positive regulation of chromosome organization GO:2001252 41 0.180
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.173
post embryonic development GO:0009791 2 0.169
purine ribonucleoside metabolic process GO:0046128 437 0.169
regulation of cell cycle process GO:0010564 266 0.168
proteasomal protein catabolic process GO:0010498 176 0.165
positive regulation of response to dna damage stimulus GO:2001022 43 0.162
regulation of chromosome segregation GO:0051983 44 0.152
nucleoside catabolic process GO:0009164 408 0.151
positive regulation of cell cycle process GO:0090068 106 0.148
positive regulation of cell cycle GO:0045787 140 0.146
regulation of nuclear division GO:0051783 65 0.144
mitotic sister chromatid cohesion GO:0007064 12 0.142
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.141
meiosis i GO:0007127 4 0.131
positive regulation of proteolysis GO:0045862 142 0.130
regulation of mitotic sister chromatid separation GO:0010965 27 0.128
negative regulation of cell cycle process GO:0010948 121 0.126
positive regulation of chromosome segregation GO:0051984 9 0.123
positive regulation of nuclear division GO:0051785 27 0.118
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.115
recombinational repair GO:0000725 50 0.114
Yeast
nucleoside phosphate catabolic process GO:1901292 412 0.110
regulation of transferase activity GO:0051338 355 0.109
positive regulation of organelle organization GO:0010638 195 0.108
aging GO:0007568 66 0.107
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.104
negative regulation of protein modification process GO:0031400 200 0.103
spindle organization GO:0007051 53 0.100
regulation of cell division GO:0051302 116 0.099
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.098
purine nucleoside triphosphate catabolic process GO:0009146 392 0.096
purine nucleoside catabolic process GO:0006152 398 0.095
regulation of cytoskeleton organization GO:0051493 177 0.092
purine ribonucleoside catabolic process GO:0046130 398 0.092
anatomical structure homeostasis GO:0060249 100 0.089
endomembrane system organization GO:0010256 196 0.089
mitotic cell cycle checkpoint GO:0007093 68 0.088
positive regulation of mitotic cell cycle GO:0045931 60 0.088
positive regulation of mitotic cell cycle phase transition GO:1901992 19 0.088
nucleoside monophosphate catabolic process GO:0009125 159 0.087
ribonucleotide catabolic process GO:0009261 405 0.087
positive regulation of catabolic process GO:0009896 310 0.084
regulation of proteasomal protein catabolic process GO:0061136 87 0.082
enzyme linked receptor protein signaling pathway GO:0007167 303 0.081
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.079
negative regulation of cell cycle GO:0045786 193 0.075
ribonucleoside catabolic process GO:0042454 406 0.074
purine nucleoside triphosphate metabolic process GO:0009144 412 0.073
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.072
positive regulation of cell division GO:0051781 59 0.067
protein oligomerization GO:0051259 173 0.065
negative regulation of cell cycle phase transition GO:1901988 89 0.065
determination of adult lifespan GO:0008340 2 0.063
protein acetylation GO:0006473 116 0.063
nucleoside triphosphate metabolic process GO:0009141 422 0.063
protein homooligomerization GO:0051260 100 0.063
regulation of protein localization GO:0032880 296 0.061
purine nucleoside monophosphate catabolic process GO:0009128 158 0.060
cellular macromolecular complex assembly GO:0034622 324 0.057
organophosphate catabolic process GO:0046434 430 0.057
multicellular organismal aging GO:0010259 3 0.056
nucleoside triphosphate catabolic process GO:0009143 394 0.054
protein localization to organelle GO:0033365 280 0.053
modification dependent macromolecule catabolic process GO:0043632 212 0.050
protein modification by small protein conjugation GO:0032446 342 0.050
regulation of microtubule based process GO:0032886 74 0.049
telomere maintenance via recombination GO:0000722 4 0.049
response to growth factor GO:0070848 205 0.048
meiotic chromosome segregation GO:0045132 4 0.047
cell cycle checkpoint GO:0000075 117 0.046
regulation of cellular amino acid metabolic process GO:0006521 6 0.045
chromatin modification GO:0016568 298 0.045
negative regulation of protein processing GO:0010955 142 0.044
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.044
negative regulation of hydrolase activity GO:0051346 182 0.044
protein maturation GO:0051604 233 0.043
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.043
centrosome organization GO:0051297 58 0.043
cellular ketone metabolic process GO:0042180 80 0.042
regulation of dna metabolic process GO:0051052 153 0.042
purine nucleotide catabolic process GO:0006195 405 0.042
protein catabolic process GO:0030163 325 0.042
ribonucleoside triphosphate catabolic process GO:0009203 391 0.040
centrosome duplication GO:0051298 28 0.039
negative regulation of catalytic activity GO:0043086 335 0.038
regulation of protein acetylation GO:1901983 25 0.037
protein import into nucleus GO:0006606 104 0.037
dna conformation change GO:0071103 113 0.037
modification dependent protein catabolic process GO:0019941 209 0.036
regulation of protein transport GO:0051223 213 0.035
regulation of microtubule cytoskeleton organization GO:0070507 61 0.034
ribonucleoside triphosphate metabolic process GO:0009199 412 0.034
regulation of sister chromatid segregation GO:0033045 27 0.034
protein processing GO:0016485 226 0.034
protein autophosphorylation GO:0046777 123 0.034
regulation of cellular amine metabolic process GO:0033238 11 0.033
negative regulation of mitotic cell cycle GO:0045930 102 0.032
purine ribonucleotide catabolic process GO:0009154 404 0.032
rna processing GO:0006396 255 0.032
ubiquitin dependent protein catabolic process GO:0006511 206 0.032
regulation of growth GO:0040008 165 0.032
intracellular protein transport GO:0006886 270 0.031
positive regulation of cellular component biogenesis GO:0044089 158 0.031
ribonucleoside monophosphate catabolic process GO:0009158 158 0.030
protein ubiquitination GO:0016567 314 0.030
negative regulation of proteolysis GO:0045861 132 0.030
nucleoside monophosphate metabolic process GO:0009123 191 0.030
growth GO:0040007 202 0.030
positive regulation of cellular amine metabolic process GO:0033240 7 0.029
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.029
glycosyl compound catabolic process GO:1901658 413 0.029
peptidyl serine phosphorylation GO:0018105 101 0.028
purine containing compound catabolic process GO:0072523 411 0.028
purine nucleoside monophosphate metabolic process GO:0009126 186 0.028
positive regulation of protein phosphorylation GO:0001934 313 0.027
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.027
positive regulation of hydrolase activity GO:0051345 331 0.027
cytoplasmic transport GO:0016482 379 0.027
cell activation GO:0001775 213 0.027
amine metabolic process GO:0009308 44 0.026
regulation of gtp catabolic process GO:0033124 180 0.026
peptidyl serine modification GO:0018209 106 0.026
response to abiotic stimulus GO:0009628 336 0.026
response to oxidative stress GO:0006979 121 0.026
positive regulation of intracellular protein transport GO:0090316 76 0.026
cellular response to growth factor stimulus GO:0071363 197 0.026
covalent chromatin modification GO:0016569 254 0.026
nucleotide catabolic process GO:0009166 408 0.025
microtubule organizing center organization GO:0031023 62 0.025
regulation of cytokine production GO:0001817 232 0.024
positive regulation of protein transport GO:0051222 135 0.024
positive regulation of phosphorylation GO:0042327 394 0.024
positive regulation of transferase activity GO:0051347 227 0.023
cilium morphogenesis GO:0060271 75 0.023
cellular amino acid metabolic process GO:0006520 116 0.023
cellular response to oxidative stress GO:0034599 85 0.023
mitotic spindle organization GO:0007052 27 0.023
signal transduction by phosphorylation GO:0023014 297 0.023
vasculature development GO:0001944 181 0.023
regulation of protein kinase activity GO:0045859 289 0.022
asymmetric neuroblast division GO:0055059 1 0.022
negative regulation of phosphate metabolic process GO:0045936 267 0.021
ras protein signal transduction GO:0007265 73 0.021
response to cytokine GO:0034097 232 0.021
small gtpase mediated signal transduction GO:0007264 78 0.021
nervous system development GO:0007399 293 0.021
negative regulation of cellular component organization GO:0051129 235 0.021
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
regulation of protein maturation GO:1903317 150 0.020
anatomical structure formation involved in morphogenesis GO:0048646 284 0.020
regulation of small gtpase mediated signal transduction GO:0051056 156 0.020
positive regulation of transport GO:0051050 336 0.020
blood vessel development GO:0001568 172 0.020
negative regulation of protein maturation GO:1903318 142 0.019
regulation of protein processing GO:0070613 150 0.019
embryonic epithelial tube formation GO:0001838 4 0.019
dna catabolic process exonucleolytic GO:0000738 17 0.019
regulation of ras protein signal transduction GO:0046578 155 0.019
regulation of cellular component biogenesis GO:0044087 281 0.019
regulation of cellular ketone metabolic process GO:0010565 50 0.019
cell development GO:0048468 328 0.019
establishment or maintenance of cell polarity GO:0007163 31 0.019
regulation of cell development GO:0060284 161 0.019
histone modification GO:0016570 251 0.019
actin filament based process GO:0030029 224 0.019
female gamete generation GO:0007292 2 0.019
maintenance of location GO:0051235 112 0.019
negative regulation of organelle organization GO:0010639 126 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
response to radiation GO:0009314 151 0.018
cellular amine metabolic process GO:0044106 41 0.018
dna replication GO:0006260 116 0.018
positive regulation of intracellular transport GO:0032388 104 0.018
single organism cellular localization GO:1902580 332 0.018
organelle localization GO:0051640 84 0.018
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.018
atp catabolic process GO:0006200 157 0.018
chromatin organization GO:0006325 351 0.017
protein targeting GO:0006605 187 0.017
vesicle mediated transport GO:0016192 371 0.017
regulation of nucleocytoplasmic transport GO:0046822 98 0.017
regulation of establishment of protein localization GO:0070201 242 0.017
positive regulation of metaphase anaphase transition of cell cycle GO:1902101 6 0.017
behavior GO:0007610 112 0.017
regulation of response to external stimulus GO:0032101 222 0.017
dephosphorylation GO:0016311 209 0.017
regulation of meiosis GO:0040020 3 0.016
protein acylation GO:0043543 138 0.016
neurogenesis GO:0022008 169 0.016
cellular response to organonitrogen compound GO:0071417 124 0.016
cilium organization GO:0044782 68 0.016
regulation of nervous system development GO:0051960 88 0.016
fibroblast growth factor receptor signaling pathway GO:0008543 26 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.016
negative regulation of chromosome organization GO:2001251 48 0.015
mitotic spindle checkpoint GO:0071174 18 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
regulation of cell motility GO:2000145 299 0.015
cell part morphogenesis GO:0032990 137 0.015
apoptotic signaling pathway GO:0097190 268 0.015
lipid metabolic process GO:0006629 381 0.015
negative regulation of phosphatase activity GO:0010923 61 0.015
regulation of kinase activity GO:0043549 314 0.015
regulation of intracellular transport GO:0032386 195 0.015
cell projection organization GO:0030030 252 0.015
cellular protein complex assembly GO:0043623 188 0.015
neuronal action potential GO:0019228 9 0.015
atp metabolic process GO:0046034 176 0.015
embryo development GO:0009790 123 0.014
Worm
negative regulation of cell death GO:0060548 345 0.014
ribonucleoside monophosphate metabolic process GO:0009161 187 0.014
oogenesis GO:0048477 2 0.014
regulation of neuron differentiation GO:0045664 70 0.014
cellular response to endogenous stimulus GO:0071495 336 0.014
reproductive system development GO:0061458 56 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.014
protein localization to nucleus GO:0034504 136 0.014
response to fibroblast growth factor GO:0071774 39 0.014
neuromuscular junction development GO:0007528 3 0.014
circulatory system development GO:0072359 262 0.014
protein import GO:0017038 130 0.014
centrosome cycle GO:0007098 32 0.013
regulation of intracellular protein transport GO:0033157 123 0.013
regulation of anatomical structure morphogenesis GO:0022603 286 0.013
mitotic spindle assembly checkpoint GO:0007094 14 0.013
regulation of nucleoside metabolic process GO:0009118 209 0.013
ribonucleoprotein complex biogenesis GO:0022613 116 0.012
negative regulation of catabolic process GO:0009895 104 0.012
actin cytoskeleton organization GO:0030036 207 0.012
single organism nuclear import GO:1902593 104 0.012
establishment of protein localization to organelle GO:0072594 172 0.012
erk1 and erk2 cascade GO:0070371 104 0.012
signal transduction by p53 class mediator GO:0072331 72 0.012
cell cycle g2 m phase transition GO:0044839 43 0.012
regulation of immune response GO:0050776 201 0.012
positive regulation of cell projection organization GO:0031346 64 0.012
defense response GO:0006952 315 0.012
ncrna processing GO:0034470 83 0.012
internal protein amino acid acetylation GO:0006475 101 0.012
cell growth GO:0016049 160 0.012
negative regulation of programmed cell death GO:0043069 321 0.012
regulation of purine nucleotide catabolic process GO:0033121 205 0.012
dna catabolic process GO:0006308 49 0.011
regulation of cellular response to growth factor stimulus GO:0090287 76 0.011
cellular component morphogenesis GO:0032989 314 0.011
positive regulation of protein complex assembly GO:0031334 86 0.011
reproduction GO:0000003 63 0.011
segmentation GO:0035282 4 0.011
guanosine containing compound metabolic process GO:1901068 244 0.011
regulation of protein targeting GO:1903533 91 0.011
positive regulation of kinase activity GO:0033674 204 0.011
response to inorganic substance GO:0010035 127 0.011
regulation of dephosphorylation GO:0035303 96 0.011
nuclear transport GO:0051169 179 0.011
response to other organism GO:0051707 261 0.011
extrinsic apoptotic signaling pathway GO:0097191 119 0.011
positive regulation of cellular protein catabolic process GO:1903364 37 0.011
regulation of cell growth GO:0001558 135 0.011
positive regulation of gtpase activity GO:0043547 166 0.011
regulation of dna repair GO:0006282 47 0.010
single organism membrane organization GO:0044802 268 0.010
regulation of cellular component movement GO:0051270 334 0.010
wound healing GO:0042060 115 0.010
stem cell division GO:0017145 2 0.010
establishment of spindle localization GO:0051293 12 0.010
peptidyl lysine acetylation GO:0018394 101 0.010
ribonucleoprotein complex subunit organization GO:0071826 81 0.010
g2 m transition of mitotic cell cycle GO:0000086 41 0.010
transcription initiation from rna polymerase i promoter GO:0006361 2 0.010
negative regulation of dephosphorylation GO:0035305 63 0.010

SMC6 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.016
nervous system disease DOID:863 431 0.016
immune system disease DOID:2914 155 0.016
disease of cellular proliferation DOID:14566 174 0.010
cancer DOID:162 167 0.010