Homo sapiens

43 known processes

SMURF2

SMAD specific E3 ubiquitin protein ligase 2

(Aliases: MGC138150,DKFZp686F0270)

SMURF2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
regulation of ketone biosynthetic process GO:0010566 7 1.000
Yeast
development involved in symbiotic interaction GO:0044111 1 1.000
Human
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 28 1.000
Human
negative regulation of sodium ion transmembrane transport GO:1902306 2 1.000
Human
polyprenol biosynthetic process GO:0016094 1 1.000
Yeast
regulation of mrna export from nucleus GO:0010793 3 1.000
Yeast
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 1.000
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 1.000
Human Fly
negative regulation of sodium ion transport GO:0010766 3 1.000
Human
dissemination or transmission of organism from other organism involved in symbiotic interaction GO:0051821 1 1.000
Human
regulation of endosome size GO:0051036 3 1.000
Yeast
transforming growth factor beta receptor signaling pathway GO:0007179 76 1.000
Human Fly
negative regulation of sodium ion transmembrane transporter activity GO:2000650 2 1.000
Human
positive regulation of proteasomal protein catabolic process GO:1901800 35 1.000
Yeast
response to transforming growth factor beta GO:0071559 94 1.000
Human Fly
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 48 1.000
Human
bmp signaling pathway GO:0030509 49 1.000
Human Fly
transmission of virus GO:0019089 1 1.000
Human
dolichol biosynthetic process GO:0019408 1 1.000
Yeast
regulation of ribosome biogenesis GO:0090069 1 1.000
Yeast
polyprenol metabolic process GO:0016093 3 1.000
Yeast
regulation of pathway restricted smad protein phosphorylation GO:0060393 34 1.000
trna export from nucleus GO:0006409 1 1.000
Yeast
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 1.000
Human Fly
negative regulation of bmp signaling pathway GO:0030514 17 1.000
Fly
dissemination or transmission of symbiont from host GO:0044007 1 1.000
Human
regulation of cellular response to growth factor stimulus GO:0090287 76 1.000
Human
dolichol metabolic process GO:0019348 3 1.000
Yeast
smad protein complex assembly GO:0007183 12 1.000
regulation of activin receptor signaling pathway GO:0032925 14 1.000
regulation of rrna processing GO:2000232 1 1.000
Yeast
negative regulation of potassium ion transmembrane transporter activity GO:1901017 3 1.000
Human
rrna containing ribonucleoprotein complex export from nucleus GO:0071428 4 1.000
Yeast
cellular response to endogenous stimulus GO:0071495 336 0.999
Human Fly
ribosomal large subunit export from nucleus GO:0000055 3 0.999
Yeast
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.999
Yeast
regulation of proteasomal protein catabolic process GO:0061136 87 0.999
Yeast
establishment of ribosome localization GO:0033753 4 0.999
Yeast
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.999
Human Fly
ubiquitin dependent smad protein catabolic process GO:0030579 4 0.999
protein polyubiquitination GO:0000209 110 0.999
Human Yeast
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.999
Human
regulation of multivesicular body size GO:0010796 1 0.999
Yeast
evasion or tolerance of host defenses GO:0044415 2 0.999
regulation of transcription from rna polymerase ii promoter in response to uv induced dna damage GO:0010767 1 0.999
Human
regulation of membrane repolarization GO:0060306 16 0.999
Human
modification dependent macromolecule catabolic process GO:0043632 212 0.998
protein modification by small protein conjugation GO:0032446 342 0.998
potassium ion transport GO:0006813 62 0.998
Human
positive regulation of cytoplasmic transport GO:1903651 82 0.998
Human
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.998
Yeast
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.998
Yeast
pathway restricted smad protein phosphorylation GO:0060389 38 0.997
avoidance of defenses of other organism involved in symbiotic interaction GO:0051832 2 0.997
response to biotic stimulus GO:0009607 276 0.997
Human
negative regulation of cellular response to growth factor stimulus GO:0090288 41 0.997
Human
oxidoreduction coenzyme metabolic process GO:0006733 19 0.997
Yeast
retinal ganglion cell axon guidance GO:0031290 2 0.997
nuclear transport GO:0051169 179 0.997
Human Yeast
positive regulation of catabolic process GO:0009896 310 0.997
Human Yeast
response to growth factor GO:0070848 205 0.997
Human Fly
interaction with host GO:0051701 42 0.997
Human
positive regulation of proteolysis GO:0045862 142 0.997
Yeast
ubiquitin dependent endocytosis GO:0070086 1 0.996
Yeast
regulation of isoprenoid metabolic process GO:0019747 1 0.996
Yeast
potassium ion transmembrane transport GO:0071805 60 0.996
Human
positive regulation of fatty acid biosynthetic process GO:0045723 5 0.996
Yeast
positive regulation of bmp signaling pathway GO:0030513 9 0.996
regulation of potassium ion transmembrane transporter activity GO:1901016 16 0.996
Human
common partner smad protein phosphorylation GO:0007182 3 0.995
coenzyme biosynthetic process GO:0009108 24 0.995
Yeast
regulation of nucleocytoplasmic transport GO:0046822 98 0.994
Human Yeast
protein localization to lysosome GO:0061462 11 0.994
Human
protein k29 linked ubiquitination GO:0035519 4 0.994
Human
trna transport GO:0051031 1 0.994
Yeast
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.994
Human
regulation of cytoplasmic transport GO:1903649 149 0.994
Human Yeast
activin receptor signaling pathway GO:0032924 24 0.993
positive regulation of protein catabolic process GO:0045732 75 0.993
Human Yeast
positive regulation of stem cell differentiation GO:2000738 29 0.993
receptor catabolic process GO:0032801 11 0.993
Human
regulation of coenzyme metabolic process GO:0051196 3 0.993
Yeast
multi organism cellular process GO:0044764 156 0.992
Human Yeast
enzyme linked receptor protein signaling pathway GO:0007167 303 0.992
protein k48 linked ubiquitination GO:0070936 38 0.991
Human
chromatin assembly or disassembly GO:0006333 78 0.990
Yeast
interspecies interaction between organisms GO:0044419 156 0.990
Human
neuron projection development GO:0031175 106 0.989
Human
positive regulation of intracellular transport GO:0032388 104 0.989
Human
protein ubiquitination GO:0016567 314 0.988
regulation of cellular protein catabolic process GO:1903362 96 0.987
Yeast
isoprenoid biosynthetic process GO:0008299 9 0.987
Yeast
nucleocytoplasmic transport GO:0006913 176 0.987
Human Yeast
negative regulation of protein localization to cell surface GO:2000009 5 0.986
Human
ribosomal subunit export from nucleus GO:0000054 4 0.985
Yeast
quinone biosynthetic process GO:1901663 6 0.984
Yeast
evasion or tolerance of defenses of other organism involved in symbiotic interaction GO:0051834 2 0.983
ribonucleoprotein complex localization GO:0071166 4 0.983
Yeast
regulation of epithelial to mesenchymal transition GO:0010717 37 0.983
cellular response to growth factor stimulus GO:0071363 197 0.982
Human Fly
steroid biosynthetic process GO:0006694 46 0.982
Yeast
stem cell differentiation GO:0048863 93 0.981
response to other organism GO:0051707 261 0.981
Human
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.979
Yeast
mesenchymal cell development GO:0014031 50 0.979
regulation of establishment of protein localization GO:0070201 242 0.979
Human
modification dependent protein catabolic process GO:0019941 209 0.978
cell junction assembly GO:0034329 67 0.977
regulation of cellular ketone metabolic process GO:0010565 50 0.977
Yeast
regulation of bmp signaling pathway GO:0030510 27 0.976
Fly
regulation of steroid biosynthetic process GO:0050810 23 0.976
Yeast
regulation of potassium ion transmembrane transport GO:1901379 20 0.975
Human
neuron differentiation GO:0030182 138 0.975
Human
negative regulation of peptidyl threonine phosphorylation GO:0010801 6 0.974
stem cell development GO:0048864 69 0.974
quinone metabolic process GO:1901661 18 0.973
Yeast
regulation of cofactor metabolic process GO:0051193 3 0.973
Yeast
protein k63 linked ubiquitination GO:0070534 31 0.973
Human
inorganic ion transmembrane transport GO:0098660 231 0.973
Human
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.972
Human Yeast
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.970
endosomal transport GO:0016197 129 0.970
Yeast
positive regulation of cellular protein catabolic process GO:1903364 37 0.967
Yeast
nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900164 1 0.966
lysosomal transport GO:0007041 33 0.965
Human
protein catabolic process GO:0030163 325 0.965
protein localization to organelle GO:0033365 280 0.965
Human
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.964
ubiquitin dependent protein catabolic process GO:0006511 206 0.961
zygotic specification of dorsal ventral axis GO:0007352 2 0.961
evasion or tolerance of host defenses by virus GO:0019049 2 0.961
positive regulation of cellular catabolic process GO:0031331 284 0.960
Yeast
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.959
Human
small molecule biosynthetic process GO:0044283 157 0.957
Yeast
response to host defenses GO:0052200 2 0.957
negative regulation of ion transmembrane transport GO:0034766 26 0.955
Human
negative regulation of potassium ion transmembrane transport GO:1901380 5 0.955
Human
negative regulation of cell growth GO:0030308 83 0.955
negative regulation of potassium ion transport GO:0043267 6 0.954
Human
regulation of intracellular transport GO:0032386 195 0.952
Human Yeast
negative regulation of pathway restricted smad protein phosphorylation GO:0060394 11 0.952
ketone biosynthetic process GO:0042181 17 0.949
Yeast
regulation of protein catabolic process GO:0042176 155 0.947
Human Yeast
regulation of protein transport GO:0051223 213 0.946
Human
response to external biotic stimulus GO:0043207 261 0.944
Human
cellular potassium ion transport GO:0071804 60 0.943
Human
regulation of nodal signaling pathway involved in determination of left right asymmetry GO:1900145 1 0.941
positive regulation of fatty acid metabolic process GO:0045923 11 0.940
Yeast
cellular amine metabolic process GO:0044106 41 0.937
lipid metabolic process GO:0006629 381 0.932
Yeast
organic acid biosynthetic process GO:0016053 97 0.931
Yeast
epithelial to mesenchymal transition GO:0001837 48 0.931
lateral mesoderm development GO:0048368 1 0.929
trna processing GO:0008033 23 0.924
Yeast
mitochondrion organization GO:0007005 156 0.924
Yeast
inorganic cation transmembrane transport GO:0098662 194 0.922
Human
regulation of nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900175 1 0.921
rna processing GO:0006396 255 0.920
Yeast
cell development GO:0048468 328 0.919
Human Fly
protein targeting GO:0006605 187 0.919
Human
neurogenesis GO:0022008 169 0.918
Human
endocardial cushion development GO:0003197 3 0.917
positive regulation of aldosterone metabolic process GO:0032346 2 0.916
regulation of wnt signaling pathway GO:0030111 123 0.915
negative regulation of transmembrane transport GO:0034763 29 0.914
Human
cellular macromolecule catabolic process GO:0044265 380 0.913
regulation of protein ubiquitination GO:0031396 95 0.911
response to sterol GO:0036314 14 0.907
regulation of potassium ion transport GO:0043266 24 0.906
Human
avoidance of host defenses GO:0044413 2 0.903
positive regulation of lipid biosynthetic process GO:0046889 22 0.903
Yeast
regulation of stem cell differentiation GO:2000736 56 0.902
cation transmembrane transport GO:0098655 238 0.902
Human
modulation by virus of host morphology or physiology GO:0019048 10 0.902
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.898
response to defenses of other organism involved in symbiotic interaction GO:0052173 2 0.896
establishment of protein localization to organelle GO:0072594 172 0.891
Human
nodal signaling pathway involved in determination of left right asymmetry GO:0038107 1 0.887
cellular alcohol biosynthetic process GO:0044108 7 0.887
Yeast
response to host GO:0075136 2 0.885
protein autoubiquitination GO:0051865 37 0.884
Human Yeast
positive regulation of epithelial to mesenchymal transition GO:0010718 22 0.883
mesenchymal cell differentiation GO:0048762 52 0.876
negative regulation of ubiquitin protein transferase activity GO:0051444 8 0.875
regulation of alcohol biosynthetic process GO:1902930 22 0.875
Yeast
blood vessel development GO:0001568 172 0.874
regulation of smad protein import into nucleus GO:0060390 10 0.869
positive regulation of cell adhesion GO:0045785 84 0.869
single organism cell adhesion GO:0098602 179 0.868
coenzyme metabolic process GO:0006732 65 0.861
Yeast
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.859
establishment of rna localization GO:0051236 39 0.851
Yeast
positive regulation of endocytosis GO:0045807 42 0.851
Yeast
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 41 0.845
positive regulation of mesoderm development GO:2000382 2 0.844
regulation of ligase activity GO:0051340 29 0.843
positive regulation of wnt signaling pathway GO:0030177 54 0.842
protein localization to vacuole GO:0072665 11 0.842
Human
trna metabolic process GO:0006399 35 0.839
Yeast
cellular component morphogenesis GO:0032989 314 0.838
Yeast
rrna metabolic process GO:0016072 40 0.838
Yeast
positive regulation of phosphatidylinositol 3 kinase signaling GO:0014068 28 0.832
Human
positive regulation of osteoblast differentiation GO:0045669 23 0.831
response to lipid GO:0033993 206 0.824
negative regulation of smad protein complex assembly GO:0010991 4 0.822
rna transport GO:0050658 39 0.821
Yeast
negative regulation of defense response GO:0031348 47 0.812
Human
sodium ion transport GO:0006814 61 0.812
Human
negative regulation of cell death GO:0060548 345 0.812
Human
hard palate development GO:0060022 1 0.811
mrna transport GO:0051028 30 0.809
Yeast
positive regulation of developmental process GO:0051094 314 0.808
regulation of proteolysis GO:0030162 293 0.806
Yeast
regulation of smad protein complex assembly GO:0010990 4 0.801
cellular protein catabolic process GO:0044257 261 0.794
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 10 0.789
Human Yeast
single organism cellular localization GO:1902580 332 0.786
Human
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 1 0.786
positive regulation of mesenchymal cell proliferation GO:0002053 2 0.785
adherens junction organization GO:0034332 36 0.784
regulation of lipid metabolic process GO:0019216 96 0.783
Yeast
positive regulation of peptidase activity GO:0010952 88 0.783
positive regulation of aldosterone biosynthetic process GO:0032349 2 0.782
response to abiotic stimulus GO:0009628 336 0.779
Human Yeast
positive regulation of intracellular protein transport GO:0090316 76 0.778
positive regulation of transforming growth factor beta receptor signaling pathway GO:0030511 12 0.776
positive regulation of transcription from rna polymerase ii promoter involved in cellular response to chemical stimulus GO:1901522 2 0.776
negative regulation of gliogenesis GO:0014014 3 0.775
cytoplasmic transport GO:0016482 379 0.774
Human Yeast
cellular ketone metabolic process GO:0042180 80 0.772
Yeast
membrane repolarization GO:0086009 23 0.770
Human
post embryonic development GO:0009791 2 0.766
ribosome biogenesis GO:0042254 48 0.764
Yeast
positive regulation of lipid metabolic process GO:0045834 50 0.762
Yeast
protein targeting to vacuole GO:0006623 8 0.757
Human
regulation of receptor mediated endocytosis GO:0048259 32 0.756
Yeast
negative regulation of cellular amine metabolic process GO:0033239 3 0.755
determination of left right asymmetry in lateral mesoderm GO:0003140 1 0.754
urogenital system development GO:0001655 65 0.752
stem cell division GO:0017145 2 0.749
ribonucleoprotein complex export from nucleus GO:0071426 4 0.748
Yeast
segmentation GO:0035282 4 0.747
vacuolar transport GO:0007034 34 0.746
Human Yeast
proteasomal protein catabolic process GO:0010498 176 0.743
Human Yeast
determination of bilateral symmetry GO:0009855 15 0.733
response to cholesterol GO:0070723 11 0.730
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.729
positive regulation of protein ubiquitination GO:0031398 53 0.727
regulation of mapk cascade GO:0043408 262 0.726
carboxylic acid biosynthetic process GO:0046394 97 0.714
Yeast
inositol lipid mediated signaling GO:0048017 55 0.714
Human
alcohol metabolic process GO:0006066 114 0.710
Yeast
positive regulation of cell differentiation GO:0045597 211 0.709
regulation of cytokine production GO:0001817 232 0.708
mesonephric tubule development GO:0072164 14 0.708
ncrna processing GO:0034470 83 0.706
Yeast
response to radiation GO:0009314 151 0.705
Human Yeast
positive regulation of mapk cascade GO:0043410 190 0.705
response to fluid shear stress GO:0034405 14 0.704
lipid biosynthetic process GO:0008610 177 0.702
Yeast
neuron fate commitment GO:0048663 2 0.698
adherens junction assembly GO:0034333 34 0.695
cofactor metabolic process GO:0051186 87 0.692
Yeast
sterol biosynthetic process GO:0016126 10 0.688
Yeast
negative regulation of transporter activity GO:0032410 25 0.686
Human
positive regulation of transport GO:0051050 336 0.686
Human Yeast
negative regulation of cell differentiation GO:0045596 171 0.682
autophagy GO:0006914 88 0.680
Yeast
ncrna metabolic process GO:0034660 108 0.676
Yeast
fatty acid metabolic process GO:0006631 115 0.674
Yeast
mrna export from nucleus GO:0006406 29 0.674
Yeast
defense response to other organism GO:0098542 129 0.672
Human
regulation of nodal signaling pathway GO:1900107 1 0.671
mesenchyme development GO:0060485 59 0.669
cell junction organization GO:0034330 79 0.667
organic hydroxy compound metabolic process GO:1901615 147 0.661
Yeast
stem cell maintenance GO:0019827 19 0.661
negative regulation of ion transport GO:0043271 39 0.657
Human
fatty acid biosynthetic process GO:0006633 46 0.657
Yeast
regulation of lipid biosynthetic process GO:0046890 47 0.655
Yeast
progesterone receptor signaling pathway GO:0050847 3 0.645
Human
cell cell junction organization GO:0045216 69 0.641
cell morphogenesis involved in differentiation GO:0000904 144 0.640
protein targeting to lysosome GO:0006622 8 0.638
Human
positive regulation of phosphorylation GO:0042327 394 0.634
regulation of cell development GO:0060284 161 0.632
cofactor biosynthetic process GO:0051188 31 0.629
Yeast
regulation of protein localization to cell surface GO:2000008 15 0.627
Human
regulation of osteoblast differentiation GO:0045667 38 0.627
regulation of cell differentiation GO:0045595 393 0.623
wnt signaling pathway GO:0016055 156 0.622
positive regulation of cell cell adhesion GO:0022409 22 0.620
dorsal ventral pattern formation GO:0009953 15 0.619
regulation of multi organism process GO:0043900 157 0.618
Human Yeast
cell projection organization GO:0030030 252 0.617
Human Yeast
mesonephros development GO:0001823 17 0.617
regulation of endopeptidase activity GO:0052548 170 0.615
regulation of fatty acid metabolic process GO:0019217 24 0.615
Yeast
regulation of transcription factor import into nucleus GO:0042990 39 0.612
negative regulation of programmed cell death GO:0043069 321 0.605
Human
regulation of cell growth GO:0001558 135 0.602
positive regulation of smad protein import into nucleus GO:0060391 8 0.598
rna localization GO:0006403 41 0.598
Yeast
response to organic cyclic compound GO:0014070 204 0.596
viral process GO:0016032 146 0.596
Human
ubiquinone metabolic process GO:0006743 5 0.592
Yeast
mesoderm development GO:0007498 14 0.589
canonical wnt signaling pathway GO:0060070 116 0.582
regulation of cell adhesion GO:0030155 166 0.581
intracellular receptor signaling pathway GO:0030522 104 0.580
Human
adaptive immune response GO:0002250 49 0.580
cell proliferation involved in heart valve development GO:2000793 1 0.579
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.576
Human
regulation of canonical wnt signaling pathway GO:0060828 88 0.572
regulation of jnk cascade GO:0046328 73 0.570
regulation of cell projection organization GO:0031344 107 0.568
Yeast
ubiquinone biosynthetic process GO:0006744 5 0.565
Yeast
positive regulation of programmed cell death GO:0043068 249 0.564
regulation of cell cell adhesion GO:0022407 57 0.563
regulation of transporter activity GO:0032409 82 0.559
Human
tube development GO:0035295 125 0.559
Fly
regulation of stress activated mapk cascade GO:0032872 84 0.555
positive regulation of protein transport GO:0051222 135 0.555
establishment of protein localization to vacuole GO:0072666 8 0.550
Human
receptor metabolic process GO:0043112 81 0.550
Human
regulation of protein localization GO:0032880 296 0.547
Human Yeast
response to light stimulus GO:0009416 87 0.542
Human Yeast
regulation of neuron differentiation GO:0045664 70 0.541
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.539
Human Yeast Fly
heart contraction GO:0060047 62 0.530
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 22 0.527
negative regulation of cell proliferation GO:0008285 228 0.527
regulation of transmembrane transporter activity GO:0022898 74 0.525
Human
specification of symmetry GO:0009799 16 0.522
negative regulation of protein ubiquitination GO:0031397 35 0.517
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.515
Yeast
positive regulation of protein phosphorylation GO:0001934 313 0.514
renal system development GO:0072001 63 0.511
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 35 0.508
Human
actin cytoskeleton organization GO:0030036 207 0.500
Yeast
endocardium development GO:0003157 2 0.497
regulation of intracellular protein transport GO:0033157 123 0.495
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.493
intracellular protein transport GO:0006886 270 0.493
Human
monocarboxylic acid metabolic process GO:0032787 185 0.489
Yeast
fat cell differentiation GO:0045444 32 0.488
regulation of vesicle mediated transport GO:0060627 130 0.487
Yeast
somitogenesis GO:0001756 2 0.487
regulation of defense response to virus GO:0050688 33 0.486
Human
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.485
protein monoubiquitination GO:0006513 39 0.483
Yeast
negative regulation of ligase activity GO:0051352 8 0.481
positive regulation of receptor mediated endocytosis GO:0048260 21 0.481
Yeast
positive regulation of jun kinase activity GO:0043507 23 0.479
negative regulation of immune effector process GO:0002698 38 0.478
Human
ribonucleoprotein complex biogenesis GO:0022613 116 0.476
Yeast
neuron development GO:0048666 113 0.475
Human
negative regulation of transcription by competitive promoter binding GO:0010944 8 0.474
determination of adult lifespan GO:0008340 2 0.474
regulation of membrane depolarization GO:0003254 19 0.473
Human
positive regulation of cell development GO:0010720 92 0.470
regulation of nervous system development GO:0051960 88 0.465
neural tube formation GO:0001841 3 0.465
negative regulation of muscle organ development GO:0048635 12 0.465
positive regulation of protein import into nucleus GO:0042307 46 0.464
epithelium development GO:0060429 227 0.463
defense response to virus GO:0051607 71 0.461
Human
cellular amino acid metabolic process GO:0006520 116 0.459
digestive tract development GO:0048565 75 0.458
Fly
ribosome localization GO:0033750 4 0.457
Yeast
regulation of homeostatic process GO:0032844 121 0.449
Human
cellular protein complex localization GO:0034629 8 0.447
nodal signaling pathway GO:0038092 5 0.443
defense response GO:0006952 315 0.440
Human
regulation of mesoderm development GO:2000380 4 0.439
positive regulation of protein kinase activity GO:0045860 190 0.438
nervous system development GO:0007399 293 0.436
Human
transcription factor import into nucleus GO:0042991 40 0.436
regulation of transmembrane transport GO:0034762 139 0.435
Human
regulation of cysteine type endopeptidase activity GO:2000116 127 0.435
regulation of ubiquitin protein transferase activity GO:0051438 28 0.432
nitrogen compound transport GO:0071705 191 0.430
Yeast
regulation of steroid metabolic process GO:0019218 32 0.430
Yeast
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left right asymmetry GO:1900224 1 0.428
cellular response to light stimulus GO:0071482 34 0.428
Human Yeast
transforming growth factor beta production GO:0071604 14 0.425
single organism nuclear import GO:1902593 104 0.423
alcohol biosynthetic process GO:0046165 52 0.419
Yeast
positive regulation of hydrolase activity GO:0051345 331 0.415
circulatory system development GO:0072359 262 0.414
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.414
morphogenesis of an epithelium GO:0002009 60 0.413
axis specification GO:0009798 12 0.412
response to decreased oxygen levels GO:0036293 96 0.412
regulation of nucleobase containing compound transport GO:0032239 7 0.410
Yeast
artery morphogenesis GO:0048844 7 0.408
regulation of protein import into nucleus GO:0042306 78 0.407
ion homeostasis GO:0050801 230 0.402
Human
cell substrate adhesion GO:0031589 132 0.402
generation of neurons GO:0048699 152 0.399
Human
regulation of defense response GO:0031347 154 0.395
Human
regulation of catenin import into nucleus GO:0035412 18 0.384
peptidyl threonine modification GO:0018210 45 0.380
rna export from nucleus GO:0006405 33 0.378
Yeast
response to bmp GO:0071772 8 0.374
positive regulation of stress activated mapk cascade GO:0032874 60 0.369
negative regulation of cellular component organization GO:0051129 235 0.367
catenin import into nucleus GO:0035411 18 0.365
regulation of peptidyl serine phosphorylation GO:0033135 50 0.362
positive regulation of cellular component organization GO:0051130 376 0.359
Yeast
regulation of sodium ion transmembrane transporter activity GO:2000649 17 0.357
Human
establishment of organelle localization GO:0051656 59 0.357
Yeast
nuclear export GO:0051168 69 0.356
Human Yeast
negative regulation of apoptotic process GO:0043066 316 0.355
Human
cell projection morphogenesis GO:0048858 129 0.352
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.349
positive regulation of hormone biosynthetic process GO:0046886 4 0.346
positive regulation of cell death GO:0010942 263 0.345
cardiac septum development GO:0003279 13 0.343
regulation of muscle system process GO:0090257 53 0.341
negative regulation of phosphorylation GO:0042326 174 0.337
negative regulation of immune system process GO:0002683 136 0.336
Human
negative regulation of defense response to virus GO:0050687 10 0.332
Human
positive regulation of protein localization to nucleus GO:1900182 48 0.331
smad protein signal transduction GO:0060395 10 0.331
amine metabolic process GO:0009308 44 0.330
cellular lipid metabolic process GO:0044255 303 0.330
Yeast
osteoblast differentiation GO:0001649 92 0.329
modification of morphology or physiology of other organism GO:0035821 43 0.328
negative regulation of phosphate metabolic process GO:0045936 267 0.327
protein export from nucleus GO:0006611 29 0.325
Human
regulation of protein localization to nucleus GO:1900180 85 0.325
zymogen activation GO:0031638 70 0.325
negative regulation of protein transport GO:0051224 75 0.325
Human
vesicle mediated transport GO:0016192 371 0.323
Human Yeast
negative regulation of chorionic trophoblast cell proliferation GO:1901383 2 0.322
regulation of system process GO:0044057 101 0.320
monovalent inorganic cation transport GO:0015672 128 0.318
Human
biological adhesion GO:0022610 331 0.318
regulation of sodium ion transport GO:0002028 24 0.316
Human
late endosome to vacuole transport GO:0045324 2 0.316
Yeast
regulation of ossification GO:0030278 58 0.314
cell part morphogenesis GO:0032990 137 0.314
negative regulation of developmental process GO:0051093 247 0.314
regulation of cellular component biogenesis GO:0044087 281 0.311
Yeast
muscle organ development GO:0007517 56 0.311
transforming growth factor beta2 production GO:0032906 6 0.310
nucleobase containing compound transport GO:0015931 51 0.304
Yeast
cell adhesion GO:0007155 325 0.304
cytokine production GO:0001816 247 0.302
extrinsic apoptotic signaling pathway GO:0097191 119 0.301
anatomical structure formation involved in morphogenesis GO:0048646 284 0.298
Yeast Fly
growth GO:0040007 202 0.295
Fly
kidney development GO:0001822 53 0.294
cardiac atrium morphogenesis GO:0003209 7 0.291
regulation of mineralocorticoid secretion GO:2000855 1 0.291
regulation of response to biotic stimulus GO:0002831 55 0.286
Human
organelle localization GO:0051640 84 0.284
Yeast
regulation of transferase activity GO:0051338 355 0.282
regulation of ion transmembrane transport GO:0034765 132 0.278
Human
endocrine hormone secretion GO:0060986 13 0.278
negative regulation of growth GO:0045926 97 0.277
cardiovascular system development GO:0072358 262 0.272
regulation of actin filament based process GO:0032970 141 0.272
Yeast
negative regulation of multicellular organismal process GO:0051241 317 0.271
regulation of cellular amine metabolic process GO:0033238 11 0.270
sterol metabolic process GO:0016125 28 0.268
Yeast
regulation of protein stability GO:0031647 87 0.266
regulation of cell morphogenesis GO:0022604 153 0.265
Yeast
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 38 0.265
regulation of sodium ion transmembrane transport GO:1902305 23 0.264
Human
otic vesicle development GO:0071599 1 0.261
cellular response to radiation GO:0071478 65 0.260
Human Yeast
mesonephric epithelium development GO:0072163 14 0.259
endodermal cell fate specification GO:0001714 4 0.259
positive regulation of activin receptor signaling pathway GO:0032927 6 0.257
embryo development GO:0009790 123 0.255
Fly
positive regulation of jnk cascade GO:0046330 52 0.252
immune effector process GO:0002252 159 0.251
Human
smad protein import into nucleus GO:0007184 13 0.249
phosphatidylinositol mediated signaling GO:0048015 55 0.248
Human
maintenance of location GO:0051235 112 0.247
protein stabilization GO:0050821 64 0.246
regulation of cellular component size GO:0032535 82 0.243
Yeast
glucocorticoid receptor signaling pathway GO:0042921 5 0.242
Human
regulation of immune effector process GO:0002697 91 0.240
Human
cell morphogenesis GO:0000902 296 0.239
Yeast
positive regulation of transcription factor import into nucleus GO:0042993 25 0.238
endocrine system development GO:0035270 26 0.238
atrioventricular valve development GO:0003171 3 0.237
embryonic heart tube morphogenesis GO:0003143 8 0.235

SMURF2 disease predictions

Disease DO term ID Size Probability Func Analog Org
bone disease DOID:0080001 88 0.695
musculoskeletal system disease DOID:17 223 0.695
connective tissue disease DOID:65 109 0.695
heart disease DOID:114 68 0.335
cardiovascular system disease DOID:1287 106 0.335
cancer DOID:162 167 0.289
disease of cellular proliferation DOID:14566 174 0.289