|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.999
|
|
|
|
positive regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042517 |
16 |
0.998
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.997
|
|
|
|
regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042516 |
18 |
0.996
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.994
|
Human Mouse |
|
|
ciliary neurotrophic factor mediated signaling pathway
|
GO:0070120 |
5 |
0.994
|
|
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.993
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.993
|
|
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.993
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.984
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.983
|
|
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.983
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.982
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.979
|
Rat |
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.978
|
Human |
|
|
cytokine production
|
GO:0001816 |
247 |
0.978
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.975
|
Rat |
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.973
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.973
|
Rat |
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.972
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.971
|
Rat |
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.968
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.966
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.964
|
Human Rat |
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.964
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.964
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.962
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.958
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.954
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.953
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.952
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.943
|
Human |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.942
|
Human Mouse Rat |
|
|
defense response
|
GO:0006952 |
315 |
0.942
|
Mouse |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.941
|
Human Mouse |
|
|
negative regulation of cytokine mediated signaling pathway
|
GO:0001960 |
22 |
0.939
|
|
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.939
|
|
|
|
tyrosine phosphorylation of stat3 protein
|
GO:0042503 |
20 |
0.936
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.933
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.932
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.931
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.921
|
|
|
|
cellular response to growth hormone stimulus
|
GO:0071378 |
10 |
0.920
|
Human |
|
|
leukemia inhibitory factor signaling pathway
|
GO:0048861 |
3 |
0.919
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.918
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.913
|
Human Mouse |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.910
|
Mouse |
|
|
cell activation
|
GO:0001775 |
213 |
0.903
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.895
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.886
|
Zebrafish |
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.882
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.876
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.873
|
Rat |
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.872
|
Human Mouse |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.870
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.870
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
48 |
0.869
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.868
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.865
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.853
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.853
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.843
|
Zebrafish |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.839
|
Rat |
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.837
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.836
|
Human Mouse |
|
|
interleukin 27 mediated signaling pathway
|
GO:0070106 |
1 |
0.831
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.830
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.821
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.814
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.807
|
|
|
|
sex determination
|
GO:0007530 |
3 |
0.797
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.795
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.793
|
|
|
|
interleukin 2 mediated signaling pathway
|
GO:0038110 |
3 |
0.789
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.788
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.778
|
Mouse |
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.775
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.772
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.758
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
11 |
0.750
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.743
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.743
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.742
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.740
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.738
|
Rat |
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.734
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.733
|
Mouse |
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.731
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.724
|
Mouse |
|
|
regulation of interleukin 6 mediated signaling pathway
|
GO:0070103 |
3 |
0.722
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.720
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.719
|
|
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.718
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.713
|
|
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.705
|
|
|
|
gastrulation
|
GO:0007369 |
51 |
0.704
|
|
|
|
oncostatin m mediated signaling pathway
|
GO:0038165 |
3 |
0.704
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.699
|
Zebrafish Rat |
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.682
|
Rat |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.671
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.666
|
Zebrafish Mouse |
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.656
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.655
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.651
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.648
|
|
|
|
regulation of leukocyte differentiation
|
GO:1902105 |
61 |
0.633
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.629
|
|
|
|
osteoblast differentiation
|
GO:0001649 |
92 |
0.628
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.626
|
|
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.622
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.620
|
|
|
|
positive regulation of mononuclear cell proliferation
|
GO:0032946 |
47 |
0.617
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.612
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.609
|
Zebrafish Mouse |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.604
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.600
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.596
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.592
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.592
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.590
|
|
|
|
cell migration involved in gastrulation
|
GO:0042074 |
1 |
0.589
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.578
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.566
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.559
|
|
|
|
activation of janus kinase activity
|
GO:0042976 |
7 |
0.548
|
|
|
|
positive regulation of t cell activation
|
GO:0050870 |
54 |
0.542
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.542
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.538
|
|
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.536
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.528
|
Human Mouse |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.524
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.522
|
Human Mouse |
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.521
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.521
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.514
|
Human |
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.514
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.513
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.508
|
|
|
|
cellular response to interleukin 15
|
GO:0071350 |
6 |
0.503
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.499
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.499
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.498
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.491
|
Mouse |
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.490
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.488
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.484
|
Zebrafish |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.483
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.480
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.471
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
23 |
0.470
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.469
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.469
|
Human Mouse Rat |
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.468
|
Zebrafish Mouse |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.461
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.461
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.461
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.459
|
|
|
|
negative regulation of cell adhesion
|
GO:0007162 |
64 |
0.459
|
|
|
|
interleukin 6 mediated signaling pathway
|
GO:0070102 |
7 |
0.458
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.454
|
Mouse |
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.453
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.453
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.445
|
|
|
|
negative regulation of t cell apoptotic process
|
GO:0070233 |
4 |
0.443
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.434
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.430
|
Human |
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.429
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
84 |
0.427
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.424
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.424
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.422
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.417
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.417
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.413
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.413
|
|
|
|
response to growth hormone
|
GO:0060416 |
11 |
0.412
|
Human |
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.403
|
|
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.402
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.392
|
Zebrafish Mouse |
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.389
|
Human |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.385
|
Human Mouse Rat |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.383
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.382
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.381
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.381
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.380
|
Mouse |
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.380
|
Zebrafish |
|
|
tyrosine phosphorylation of stat1 protein
|
GO:0042508 |
11 |
0.379
|
|
|
|
execution phase of apoptosis
|
GO:0097194 |
32 |
0.375
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.374
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.371
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.370
|
Mouse |
|
|
memory
|
GO:0007613 |
3 |
0.360
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.359
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.357
|
|
|
|
cellular response to interleukin 12
|
GO:0071349 |
3 |
0.356
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
46 |
0.354
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.352
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.350
|
Mouse |
|
|
neurogenesis
|
GO:0022008 |
169 |
0.348
|
Zebrafish |
|
|
positive regulation of cell substrate adhesion
|
GO:0010811 |
37 |
0.348
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.346
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.343
|
Zebrafish |
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.343
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.342
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.342
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.339
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.337
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.332
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.328
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.325
|
Human Rat |
|
|
negative regulation of binding
|
GO:0051100 |
57 |
0.324
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.323
|
Mouse |
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.315
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.315
|
|
|
|
response to interleukin 15
|
GO:0070672 |
6 |
0.312
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.312
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.310
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.310
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.309
|
Human |
|
|
ossification
|
GO:0001503 |
121 |
0.302
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.299
|
|
|
|
positive regulation of osteoblast differentiation
|
GO:0045669 |
23 |
0.298
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.296
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.296
|
|
|
|
negative regulation of response to cytokine stimulus
|
GO:0060761 |
25 |
0.295
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.293
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.287
|
|
|
|
leukocyte activation involved in immune response
|
GO:0002366 |
30 |
0.282
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.282
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.280
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.275
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.274
|
|
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.273
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.271
|
|
|
|
interleukin 12 mediated signaling pathway
|
GO:0035722 |
3 |
0.269
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.267
|
Zebrafish Mouse |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.267
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.266
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.263
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.261
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.261
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.260
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.260
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.258
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.254
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.254
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.251
|
Human Mouse Rat |
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.251
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.247
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.245
|
Human Mouse |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.243
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.239
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
48 |
0.233
|
|
|
|
response to axon injury
|
GO:0048678 |
1 |
0.232
|
Zebrafish |
|
|
positive regulation of interferon gamma production
|
GO:0032729 |
26 |
0.231
|
|
|
|
positive regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042523 |
11 |
0.230
|
|
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.227
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.227
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.225
|
|
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
38 |
0.222
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.221
|
|
|
|
t helper cell differentiation
|
GO:0042093 |
4 |
0.220
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.218
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.217
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.217
|
|
|
|
growth
|
GO:0040007 |
202 |
0.215
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.210
|
|
|
|
system process
|
GO:0003008 |
349 |
0.209
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.208
|
|
|
|
brain development
|
GO:0007420 |
97 |
0.206
|
|
|
|
response to hydrogen peroxide
|
GO:0042542 |
40 |
0.205
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.205
|
Zebrafish |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.205
|
|
|
|
reactive oxygen species biosynthetic process
|
GO:1903409 |
4 |
0.204
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.203
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.202
|
|
|
|
cyclic nucleotide metabolic process
|
GO:0009187 |
82 |
0.200
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.200
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.199
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.199
|
Human Rat |
|
|
reproductive process
|
GO:0022414 |
106 |
0.195
|
Mouse |
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.195
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.194
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.194
|
Human |
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.191
|
|
|
|
positive regulation of lipid metabolic process
|
GO:0045834 |
50 |
0.189
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.189
|
Zebrafish |
|
|
regulation of angiogenesis
|
GO:0045765 |
92 |
0.188
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.188
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.186
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.186
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.186
|
|
|
|
regulation of tumor necrosis factor superfamily cytokine production
|
GO:1903555 |
44 |
0.185
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.184
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.183
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.183
|
|
|
|
response to estradiol
|
GO:0032355 |
23 |
0.182
|
Human Rat |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.180
|
|
|
|
negative regulation of cytokine production
|
GO:0001818 |
82 |
0.179
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.178
|
|
|
|
negative regulation of humoral immune response
|
GO:0002921 |
7 |
0.178
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.177
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.176
|
Zebrafish |
|
|
cellular response to reactive oxygen species
|
GO:0034614 |
50 |
0.175
|
|
|
|
cellular response to interleukin 6
|
GO:0071354 |
14 |
0.173
|
|
|
|
positive regulation of cell size
|
GO:0045793 |
3 |
0.171
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.170
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.168
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.166
|
Human |
|
|
epithelial cell development
|
GO:0002064 |
34 |
0.165
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.165
|
Zebrafish |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.164
|
Human |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.162
|
|
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.159
|
|
|
|
regulation of leukocyte migration
|
GO:0002685 |
63 |
0.158
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.158
|
|
|
|
cd4 positive alpha beta t cell differentiation
|
GO:0043367 |
4 |
0.158
|
|
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.158
|
|
|
|
interleukin 6 production
|
GO:0032635 |
37 |
0.158
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.157
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.157
|
|
|
|
negative regulation of interleukin 6 mediated signaling pathway
|
GO:0070104 |
2 |
0.156
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.156
|
|
|
|
antimicrobial humoral response
|
GO:0019730 |
26 |
0.155
|
|
|
|
regulation of response to cytokine stimulus
|
GO:0060759 |
46 |
0.153
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.153
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.152
|
|
|
|
head development
|
GO:0060322 |
108 |
0.152
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.151
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.151
|
Human |
|
|
cell projection morphogenesis
|
GO:0048858 |
129 |
0.150
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.150
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.148
|
Human |
|
|
protein targeting
|
GO:0006605 |
187 |
0.148
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.148
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.147
|
Human |
|
|
angiogenesis
|
GO:0001525 |
147 |
0.147
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.146
|
Human |
|
|
protein import
|
GO:0017038 |
130 |
0.145
|
|
|
|
response to salt stress
|
GO:0009651 |
3 |
0.144
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.144
|
Human |
|
|
nitric oxide biosynthetic process
|
GO:0006809 |
20 |
0.144
|
|
|
|
small molecule biosynthetic process
|
GO:0044283 |
157 |
0.143
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.143
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.141
|
|
|
|
cell part morphogenesis
|
GO:0032990 |
137 |
0.141
|
|
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.141
|
|
|
|
activation of jak2 kinase activity
|
GO:0042977 |
5 |
0.140
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.137
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.136
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.136
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.136
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.135
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.135
|
|
|
|
cellular response to fibroblast growth factor stimulus
|
GO:0044344 |
39 |
0.133
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.131
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.131
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.130
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.129
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.128
|
|
|
|
regulation of macrophage derived foam cell differentiation
|
GO:0010743 |
14 |
0.127
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.124
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.122
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.122
|
Zebrafish |
|
|
cell activation involved in immune response
|
GO:0002263 |
30 |
0.121
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.120
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.118
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.118
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.116
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.115
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.114
|
|
|
|
regulation of protein tyrosine kinase activity
|
GO:0061097 |
36 |
0.113
|
Human |
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.112
|
Rat |
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.112
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.112
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.111
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.111
|
Zebrafish |
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.110
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.109
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.108
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.108
|
|
|
|
regulation of vasculature development
|
GO:1901342 |
97 |
0.108
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.107
|
|
|
|
response to interleukin 4
|
GO:0070670 |
7 |
0.107
|
|
|
|
regulation of cell substrate adhesion
|
GO:0010810 |
68 |
0.107
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.106
|
|
|
|
defense response to gram positive bacterium
|
GO:0050830 |
29 |
0.106
|
|
|
|
tumor necrosis factor superfamily cytokine production
|
GO:0071706 |
45 |
0.106
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.106
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.105
|
|
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.105
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.104
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.103
|
|
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.103
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.102
|
Human Mouse Rat |
|
|
wound healing
|
GO:0042060 |
115 |
0.100
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.100
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.100
|
|
|
|
negative regulation of cytokine production involved in immune response
|
GO:0002719 |
13 |
0.099
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.098
|
Human Mouse |
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.098
|
|
|
|
thymocyte apoptotic process
|
GO:0070242 |
2 |
0.097
|
|
|
|
actin mediated cell contraction
|
GO:0070252 |
12 |
0.096
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.096
|
|
|
|
interleukin 1 beta production
|
GO:0032611 |
22 |
0.096
|
|
|
|
b cell differentiation
|
GO:0030183 |
6 |
0.095
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.095
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
0.095
|
Human Mouse Rat |
|
|
negative regulation of neuron death
|
GO:1901215 |
32 |
0.094
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.094
|
|
|
|
negative regulation of cd4 positive alpha beta t cell activation
|
GO:2000515 |
1 |
0.094
|
|
|
|
positive regulation of defense response
|
GO:0031349 |
87 |
0.094
|
|
|
|
response to interferon gamma
|
GO:0034341 |
39 |
0.094
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.094
|
|
|
|
cellular response to metal ion
|
GO:0071248 |
43 |
0.093
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.093
|
|
|
|
negative regulation of striated muscle cell apoptotic process
|
GO:0010664 |
2 |
0.093
|
|
|
|
cd4 positive alpha beta t cell differentiation involved in immune response
|
GO:0002294 |
4 |
0.093
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.092
|
|
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.092
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.091
|
Zebrafish |
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.091
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.091
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.091
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.090
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.090
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.090
|
Mouse |
|
|
response to hypoxia
|
GO:0001666 |
96 |
0.090
|
Rat |
|
|
organonitrogen compound biosynthetic process
|
GO:1901566 |
200 |
0.090
|
|
|
|
response to organophosphorus
|
GO:0046683 |
41 |
0.090
|
|
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.089
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.089
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.088
|
|
|
|
sensory organ development
|
GO:0007423 |
52 |
0.087
|
Zebrafish |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.087
|
Human |
|
|
regulation of odontogenesis
|
GO:0042481 |
4 |
0.086
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.085
|
|
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.085
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.084
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.084
|
Human |
|
|
positive regulation of endothelial cell proliferation
|
GO:0001938 |
37 |
0.084
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.084
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.083
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.083
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.083
|
|
|
|
positive regulation of leukocyte migration
|
GO:0002687 |
46 |
0.083
|
|
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.082
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.082
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.082
|
Human |
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.082
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.082
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.082
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.081
|
|
|
|
regulation of smooth muscle cell proliferation
|
GO:0048660 |
28 |
0.081
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.080
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.080
|
|
|
|
regulation of embryonic development
|
GO:0045995 |
20 |
0.080
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.079
|
|
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.079
|
|
|
|
cellular response to interferon gamma
|
GO:0071346 |
24 |
0.079
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.079
|
|
|
|
response to interleukin 13
|
GO:0035962 |
4 |
0.078
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.078
|
|
|
|
regulation of macrophage chemotaxis
|
GO:0010758 |
4 |
0.078
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.077
|
|
|
|
rhythmic process
|
GO:0048511 |
31 |
0.077
|
|
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.077
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.076
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.076
|
Human |
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.075
|
|
|
|
zymogen activation
|
GO:0031638 |
70 |
0.075
|
|
|
|
interleukin 4 mediated signaling pathway
|
GO:0035771 |
3 |
0.074
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.074
|
Mouse |
|
|
regulation of interferon gamma production
|
GO:0032649 |
36 |
0.074
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.073
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.073
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.073
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.072
|
Human |
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.072
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.071
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.070
|
Zebrafish |
|
|
hormone transport
|
GO:0009914 |
68 |
0.070
|
|
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.070
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.070
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.069
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.069
|
|
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.069
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
44 |
0.069
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.069
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.068
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.068
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.068
|
|
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.068
|
|
