|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.999
|
Human Mouse Fly |
|
|
tor signaling
|
GO:0031929 |
39 |
0.998
|
|
|
|
synaptic vesicle endocytosis
|
GO:0048488 |
2 |
0.998
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.995
|
Mouse |
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.980
|
|
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
31 |
0.980
|
Fly |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.979
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.973
|
Fly |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.971
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.961
|
Human Fly |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.955
|
|
|
|
positive regulation of arp2 3 complex mediated actin nucleation
|
GO:2000601 |
5 |
0.950
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.949
|
|
|
|
regulation of tor signaling
|
GO:0032006 |
30 |
0.947
|
|
|
|
regulation of phagocytosis engulfment
|
GO:0060099 |
2 |
0.938
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.931
|
|
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.930
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.924
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.917
|
Mouse |
|
|
synaptic vesicle recycling
|
GO:0036465 |
3 |
0.916
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.910
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.909
|
|
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.899
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.877
|
Human |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.870
|
Fly |
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.867
|
|
|
|
positive regulation of actin nucleation
|
GO:0051127 |
6 |
0.850
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.849
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.838
|
|
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.821
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.820
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.816
|
|
|
|
regulation of arp2 3 complex mediated actin nucleation
|
GO:0034315 |
6 |
0.814
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.805
|
Mouse |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.803
|
Human |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.796
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.796
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.795
|
|
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.792
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.783
|
|
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.782
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.774
|
|
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.772
|
Human Fly |
|
|
positive regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042523 |
11 |
0.769
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.755
|
|
|
|
positive regulation of phagocytosis engulfment
|
GO:0060100 |
1 |
0.745
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.739
|
|
|
|
regulation of actin cytoskeleton organization
|
GO:0032956 |
116 |
0.735
|
|
|
|
positive regulation of neuroblast proliferation
|
GO:0002052 |
2 |
0.728
|
|
|
|
cell division
|
GO:0051301 |
168 |
0.728
|
|
|
|
membrane budding
|
GO:0006900 |
28 |
0.727
|
|
|
|
regulation of actin nucleation
|
GO:0051125 |
10 |
0.726
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.718
|
|
|
|
barbed end actin filament capping
|
GO:0051016 |
3 |
0.712
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.709
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.708
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.699
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.692
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.683
|
Fly |
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.673
|
|
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
4 |
0.673
|
|
|
|
regulation of neuroblast proliferation
|
GO:1902692 |
3 |
0.669
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.662
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.660
|
|
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.658
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.657
|
Human |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.656
|
|
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.651
|
Fly |
|
|
cell activation
|
GO:0001775 |
213 |
0.642
|
Mouse |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.640
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.633
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.633
|
|
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.625
|
|
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.617
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.617
|
|
|
|
positive regulation of neural precursor cell proliferation
|
GO:2000179 |
2 |
0.616
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.615
|
|
|
|
positive regulation of neurogenesis
|
GO:0050769 |
49 |
0.614
|
Human |
|
|
exocytosis
|
GO:0006887 |
71 |
0.591
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
56 |
0.588
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.577
|
Human Fly |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.574
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.561
|
Human Fly |
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.558
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.555
|
Human Fly |
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.553
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.551
|
|
|
|
regulation of phospholipase c activity
|
GO:1900274 |
14 |
0.550
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.548
|
Worm |
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.545
|
|
|
|
positive regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042517 |
16 |
0.545
|
|
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.543
|
|
|
|
cell chemotaxis
|
GO:0060326 |
112 |
0.531
|
|
|
|
regulation of neuron apoptotic process
|
GO:0043523 |
35 |
0.524
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.522
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.512
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.511
|
|
|
|
regulation of apoptotic cell clearance
|
GO:2000425 |
5 |
0.510
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.501
|
Human Fly |
|
|
regulation of neuron differentiation
|
GO:0045664 |
70 |
0.499
|
Human |
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.481
|
|
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.470
|
|
|
|
cytokinesis
|
GO:0000910 |
96 |
0.467
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.466
|
Mouse |
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
0.462
|
Human |
|
|
innate immune response
|
GO:0045087 |
178 |
0.462
|
|
|
|
nerve growth factor signaling pathway
|
GO:0038180 |
4 |
0.459
|
Human |
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.458
|
Human |
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.457
|
|
|
|
vegf activated platelet derived growth factor receptor signaling pathway
|
GO:0038086 |
3 |
0.457
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.454
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.452
|
Fly |
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.448
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.448
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.444
|
|
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.444
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.442
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.438
|
Mouse |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.437
|
|
|
|
positive regulation of nitric oxide synthase biosynthetic process
|
GO:0051770 |
3 |
0.433
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.417
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.413
|
|
|
|
engulfment of apoptotic cell
|
GO:0043652 |
2 |
0.407
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.407
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.407
|
|
|
|
establishment of synaptic vesicle localization
|
GO:0097480 |
5 |
0.403
|
|
|
|
homeostasis of number of cells
|
GO:0048872 |
40 |
0.394
|
Mouse |
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.392
|
|
|
|
regulation of rap protein signal transduction
|
GO:0032487 |
9 |
0.391
|
Human |
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.391
|
|
|
|
regulation of non canonical wnt signaling pathway
|
GO:2000050 |
4 |
0.390
|
|
|
|
antimicrobial humoral response
|
GO:0019730 |
26 |
0.390
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.388
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.386
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.385
|
Mouse |
|
|
photoreceptor cell differentiation
|
GO:0046530 |
2 |
0.382
|
|
|
|
positive regulation of cell proliferation by vegf activated platelet derived growth factor receptor signaling pathway
|
GO:0038091 |
3 |
0.382
|
|
|
|
immune system development
|
GO:0002520 |
195 |
0.376
|
Mouse |
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.371
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.368
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.354
|
|
|
|
mast cell activation involved in immune response
|
GO:0002279 |
4 |
0.351
|
|
|
|
phosphatidylinositol mediated signaling
|
GO:0048015 |
55 |
0.348
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.345
|
|
|
|
phosphatidylinositol metabolic process
|
GO:0046488 |
53 |
0.344
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.342
|
|
|
|
positive regulation of actin filament polymerization
|
GO:0030838 |
38 |
0.342
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.338
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.337
|
|
|
|
negative regulation of hormone metabolic process
|
GO:0032351 |
6 |
0.337
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.337
|
|
|
|
response to ethanol
|
GO:0045471 |
11 |
0.337
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.333
|
|
|
|
hematopoietic progenitor cell differentiation
|
GO:0002244 |
38 |
0.331
|
Mouse |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.331
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.328
|
Worm Fly |
|
|
regulation of cell cycle g1 s phase transition
|
GO:1902806 |
42 |
0.327
|
Fly |
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.326
|
Human |
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.324
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.317
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.315
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.313
|
|
|
|
neuron projection morphogenesis
|
GO:0048812 |
50 |
0.312
|
Fly |
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.301
|
|
|
|
notch signaling pathway
|
GO:0007219 |
31 |
0.300
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.300
|
Human Mouse |
|
|
rap protein signal transduction
|
GO:0032486 |
7 |
0.296
|
Human |
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.296
|
|
|
|
cellular response to macrophage colony stimulating factor stimulus
|
GO:0036006 |
4 |
0.291
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.290
|
|
|
|
actin filament capping
|
GO:0051693 |
4 |
0.290
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.288
|
Fly |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.286
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.282
|
Human Fly |
|
|
behavioral response to ethanol
|
GO:0048149 |
2 |
0.281
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.280
|
Human Mouse |
|
|
synaptic vesicle transport
|
GO:0048489 |
5 |
0.280
|
|
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.272
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.268
|
Human |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.260
|
|
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.259
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.258
|
Worm |
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.257
|
Mouse |
|
|
establishment of vesicle localization
|
GO:0051650 |
23 |
0.248
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.243
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.242
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.242
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.242
|
|
|
|
calcium mediated signaling using intracellular calcium source
|
GO:0035584 |
7 |
0.242
|
|
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.240
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.240
|
|
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.240
|
|
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.240
|
|
|
|
vesicle coating
|
GO:0006901 |
9 |
0.239
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.238
|
Mouse |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.236
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.236
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.235
|
Mouse |
|
|
positive regulation of lipase activity
|
GO:0060193 |
28 |
0.235
|
|
|
|
protein depolymerization
|
GO:0051261 |
30 |
0.234
|
|
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.232
|
|
|
|
vascular endothelial growth factor receptor 1 signaling pathway
|
GO:0036323 |
1 |
0.230
|
|
|
|
positive regulation of ruffle assembly
|
GO:1900029 |
4 |
0.229
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.229
|
Fly |
|
|
eye photoreceptor cell differentiation
|
GO:0001754 |
2 |
0.225
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.222
|
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
84 |
0.222
|
|
|
|
regulation of cytokinesis
|
GO:0032465 |
45 |
0.221
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.220
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.219
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.216
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.216
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.211
|
Worm |
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.210
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.210
|
Human Fly |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.207
|
|
|
|
extracellular structure organization
|
GO:0043062 |
41 |
0.205
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.205
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.204
|
|
|
|
actin filament polymerization
|
GO:0030041 |
45 |
0.201
|
|
|
|
vesicle organization
|
GO:0016050 |
62 |
0.197
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.197
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.196
|
Fly |
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.191
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.190
|
|
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
2 |
0.190
|
|
|
|
platelet derived growth factor receptor alpha signaling pathway
|
GO:0035790 |
1 |
0.190
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.188
|
Human |
|
|
skeletal system development
|
GO:0001501 |
79 |
0.188
|
|
|
|
endoplasmic reticulum unfolded protein response
|
GO:0030968 |
16 |
0.187
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.186
|
|
|
|
spermatid development
|
GO:0007286 |
4 |
0.185
|
|
|
|
regulation of stem cell proliferation
|
GO:0072091 |
15 |
0.183
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.183
|
|
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.180
|
|
|
|
negative regulation of endothelial cell apoptotic process
|
GO:2000352 |
16 |
0.180
|
|
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.175
|
Mouse |
|
|
cellular response to stem cell factor stimulus
|
GO:0036216 |
1 |
0.173
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.173
|
|
|
|
synaptic vesicle localization
|
GO:0097479 |
5 |
0.172
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.171
|
|
|
|
negative regulation of neuron apoptotic process
|
GO:0043524 |
23 |
0.168
|
|
|
|
neuron death
|
GO:0070997 |
65 |
0.166
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.165
|
Mouse |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.164
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.163
|
Mouse |
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.161
|
|
|
|
synaptic transmission
|
GO:0007268 |
61 |
0.161
|
|
|
|
regulation of pro b cell differentiation
|
GO:2000973 |
1 |
0.160
|
Mouse |
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.160
|
|
|
|
t cell proliferation
|
GO:0042098 |
45 |
0.159
|
Mouse |
|
|
regulation of anatomical structure size
|
GO:0090066 |
101 |
0.158
|
|
|
|
positive regulation of synapse structural plasticity
|
GO:0051835 |
2 |
0.156
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.155
|
|
|
|
neurotrophin trk receptor signaling pathway
|
GO:0048011 |
4 |
0.154
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.153
|
Human |
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.152
|
Human |
|
|
response to purine containing compound
|
GO:0014074 |
40 |
0.150
|
Human |
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.147
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.145
|
Human |
|
|
positive regulation of cell cycle
|
GO:0045787 |
140 |
0.144
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.143
|
|
|
|
mast cell degranulation
|
GO:0043303 |
4 |
0.142
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.142
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.140
|
|
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.140
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.139
|
|
|
|
cell morphogenesis
|
GO:0000902 |
296 |
0.136
|
Fly |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.136
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.136
|
Fly |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.135
|
|
|
|
myeloid leukocyte activation
|
GO:0002274 |
34 |
0.133
|
|
|
|
cell junction maintenance
|
GO:0034331 |
4 |
0.133
|
|
|
|
regulation of notch signaling pathway
|
GO:0008593 |
18 |
0.133
|
|
|
|
negative regulation of cell cycle g1 s phase transition
|
GO:1902807 |
29 |
0.132
|
Fly |
|
|
post golgi vesicle mediated transport
|
GO:0006892 |
36 |
0.127
|
|
|
|
epidermis morphogenesis
|
GO:0048730 |
3 |
0.126
|
|
|
|
growth
|
GO:0040007 |
202 |
0.126
|
|
|
|
positive regulation of wnt signaling pathway planar cell polarity pathway
|
GO:2000096 |
2 |
0.125
|
|
|
|
positive regulation of nucleotide catabolic process
|
GO:0030813 |
185 |
0.125
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.125
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.124
|
Human Fly |
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.124
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.124
|
Fly |
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.124
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.124
|
Mouse |
|
|
cardiac myofibril assembly
|
GO:0055003 |
3 |
0.124
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.123
|
Human |
|
|
central nervous system neuron axonogenesis
|
GO:0021955 |
3 |
0.122
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.121
|
Human Worm |
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.120
|
Fly |
|
|
negative regulation of membrane tubulation
|
GO:1903526 |
2 |
0.119
|
|
|
|
salivary gland morphogenesis
|
GO:0007435 |
4 |
0.118
|
|
|
|
negative regulation of cell cycle phase transition
|
GO:1901988 |
89 |
0.118
|
Fly |
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.118
|
|
|
|
golgi vesicle transport
|
GO:0048193 |
80 |
0.117
|
|
|
|
tyrosine phosphorylation of stat1 protein
|
GO:0042508 |
11 |
0.117
|
|
|
|
regulation of interleukin 2 secretion
|
GO:1900040 |
2 |
0.116
|
|
|
|
regulation of actin filament length
|
GO:0030832 |
56 |
0.116
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.115
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.113
|
|
|
|
epithelial cell development
|
GO:0002064 |
34 |
0.113
|
Human |
|
|
inositol lipid mediated signaling
|
GO:0048017 |
55 |
0.113
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.112
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.112
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.110
|
|
|
|
cell morphogenesis involved in neuron differentiation
|
GO:0048667 |
44 |
0.110
|
Fly |
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.109
|
|
|
|
cell migration involved in gastrulation
|
GO:0042074 |
1 |
0.108
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.107
|
Human |
|
|
regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042522 |
12 |
0.106
|
|
|
|
positive chemotaxis
|
GO:0050918 |
33 |
0.105
|
|
|
|
pro b cell differentiation
|
GO:0002328 |
1 |
0.105
|
Mouse |
|
|
intermediate filament cytoskeleton organization
|
GO:0045104 |
17 |
0.104
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.103
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.103
|
|
|
|
regulation of growth rate
|
GO:0040009 |
1 |
0.103
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.102
|
Mouse |
|
|
positive regulation of protein tyrosine kinase activity
|
GO:0061098 |
24 |
0.102
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.102
|
|
|
|
interleukin 2 secretion
|
GO:0070970 |
3 |
0.102
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.102
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.099
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
56 |
0.098
|
|
|
|
negative regulation of rho gtpase activity
|
GO:0034259 |
4 |
0.094
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.094
|
|
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.094
|
|
|
|
positive regulation of protein polymerization
|
GO:0032273 |
45 |
0.093
|
|
|
|
er nucleus signaling pathway
|
GO:0006984 |
23 |
0.093
|
|
|
|
humoral immune response
|
GO:0006959 |
49 |
0.093
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.091
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.090
|
Mouse |
|
|
cellular response to nerve growth factor stimulus
|
GO:1990090 |
6 |
0.090
|
Human |
|
|
single organism reproductive process
|
GO:0044702 |
98 |
0.088
|
Worm |
|
|
cell fate determination
|
GO:0001709 |
3 |
0.088
|
|
|
|
kit signaling pathway
|
GO:0038109 |
1 |
0.086
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.086
|
|
|
|
positive regulation of phospholipase activity
|
GO:0010518 |
22 |
0.085
|
|
|
|
response to topologically incorrect protein
|
GO:0035966 |
29 |
0.085
|
|
|
|
negative regulation of neuron death
|
GO:1901215 |
32 |
0.085
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.085
|
|
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.084
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.084
|
|
|
|
regulation of protein depolymerization
|
GO:1901879 |
22 |
0.084
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.083
|
|
|
|
extracellular matrix organization
|
GO:0030198 |
41 |
0.083
|
|
|
|
regulation of insulin receptor signaling pathway
|
GO:0046626 |
13 |
0.082
|
|
|
|
mesenchymal stem cell differentiation
|
GO:0072497 |
8 |
0.082
|
|
|
|
regulation of cell shape
|
GO:0008360 |
48 |
0.081
|
Fly |
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.081
|
Fly |
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.081
|
|
|
|
regulation of cell projection assembly
|
GO:0060491 |
47 |
0.080
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.080
|
Fly |
|
|
regulation of growth
|
GO:0040008 |
165 |
0.079
|
|
|
|
negative regulation of actin filament polymerization
|
GO:0030837 |
10 |
0.079
|
|
|
|
actin filament bundle assembly
|
GO:0051017 |
54 |
0.079
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.077
|
|
|
|
regulation of phosphoprotein phosphatase activity
|
GO:0043666 |
23 |
0.076
|
|
|
|
adult behavior
|
GO:0030534 |
18 |
0.076
|
|
|
|
regulation of cell cycle phase transition
|
GO:1901987 |
126 |
0.076
|
Fly |
|
|
rac protein signal transduction
|
GO:0016601 |
12 |
0.076
|
Fly |
|
|
protein polymerization
|
GO:0051258 |
71 |
0.076
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.075
|
|
|
|
positive regulation of wnt signaling pathway
|
GO:0030177 |
54 |
0.075
|
|
|
|
regulation of autophagy
|
GO:0010506 |
52 |
0.075
|
|
|
|
stem cell proliferation
|
GO:0072089 |
25 |
0.074
|
|
|
|
positive regulation of endocytosis
|
GO:0045807 |
42 |
0.074
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.074
|
|
|
|
b cell activation
|
GO:0042113 |
33 |
0.074
|
|
|
|
response to organophosphorus
|
GO:0046683 |
41 |
0.073
|
Human |
|
|
central nervous system neuron development
|
GO:0021954 |
7 |
0.073
|
|
|
|
adult locomotory behavior
|
GO:0008344 |
1 |
0.072
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.072
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.071
|
|
|
|
positive regulation of cytokinesis
|
GO:0032467 |
29 |
0.071
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.071
|
Worm |
|
|
astrocyte differentiation
|
GO:0048708 |
4 |
0.071
|
|
|
|
cell cell junction maintenance
|
GO:0045217 |
4 |
0.071
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.070
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.070
|
|
|
|
cellular response to unfolded protein
|
GO:0034620 |
16 |
0.069
|
|
|
|
detection of mechanical stimulus involved in sensory perception
|
GO:0050974 |
1 |
0.069
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.069
|
|
|
|
positive regulation of protein kinase c signaling
|
GO:0090037 |
5 |
0.069
|
|
|
|
morphogenesis of a polarized epithelium
|
GO:0001738 |
3 |
0.068
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.068
|
|
|
|
positive regulation of phagocytosis
|
GO:0050766 |
15 |
0.068
|
|
|
|
ruffle organization
|
GO:0031529 |
18 |
0.068
|
|
|
|
neuron apoptotic process
|
GO:0051402 |
39 |
0.067
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.067
|
|
|
|
arp2 3 complex mediated actin nucleation
|
GO:0034314 |
17 |
0.066
|
|
|
|
axon guidance
|
GO:0007411 |
12 |
0.066
|
Fly |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.066
|
|
|
|
regulation of neuron death
|
GO:1901214 |
56 |
0.065
|
|
|
|
behavior
|
GO:0007610 |
112 |
0.065
|
Worm |
|
|
cellular response to topologically incorrect protein
|
GO:0035967 |
19 |
0.064
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.064
|
|
|
|
second messenger mediated signaling
|
GO:0019932 |
78 |
0.064
|
|
|
|
actin crosslink formation
|
GO:0051764 |
1 |
0.063
|
|
|
|
positive regulation of non canonical wnt signaling pathway
|
GO:2000052 |
3 |
0.063
|
|
|
|
axon development
|
GO:0061564 |
34 |
0.063
|
Fly |
|
|
maintenance of cell polarity
|
GO:0030011 |
2 |
0.063
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.062
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.062
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.062
|
|
|
|
negative regulation of mitotic cell cycle
|
GO:0045930 |
102 |
0.062
|
Fly |
|
|
positive regulation of synaptic transmission
|
GO:0050806 |
4 |
0.061
|
|
|
|
granulocyte migration
|
GO:0097530 |
40 |
0.061
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
0.061
|
|
|
|
positive regulation of phospholipase c activity
|
GO:0010863 |
13 |
0.061
|
|
|
|
response to macrophage colony stimulating factor
|
GO:0036005 |
4 |
0.060
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.060
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.060
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.059
|
|
|
|
developmental cell growth
|
GO:0048588 |
18 |
0.059
|
|
|
|
sensory perception of mechanical stimulus
|
GO:0050954 |
37 |
0.058
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.058
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.058
|
|
|
|
positive regulation of nervous system development
|
GO:0051962 |
54 |
0.057
|
Human |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.057
|
|
|
|
cell activation involved in immune response
|
GO:0002263 |
30 |
0.057
|
|
|
|
myeloid leukocyte migration
|
GO:0097529 |
62 |
0.056
|
|
|
|
oxidation reduction process
|
GO:0055114 |
396 |
0.056
|
|
|
|
peripheral nervous system development
|
GO:0007422 |
2 |
0.056
|
|
|
|
response to reactive oxygen species
|
GO:0000302 |
61 |
0.056
|
|
|
|
phosphatidylinositol 3 kinase signaling
|
GO:0014065 |
48 |
0.056
|
|
|
|
regulation of clathrin mediated endocytosis
|
GO:2000369 |
4 |
0.055
|
|
|
|
negative regulation of cell migration
|
GO:0030336 |
102 |
0.055
|
|
|
|
calcium mediated signaling
|
GO:0019722 |
44 |
0.055
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.055
|
|
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.055
|
|
|
|
regulation of ruffle assembly
|
GO:1900027 |
8 |
0.054
|
|
|
|
endocytosis
|
GO:0006897 |
159 |
0.054
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.054
|
|
|
|
epidermal growth factor receptor signaling pathway
|
GO:0007173 |
39 |
0.054
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.053
|
|
|
|
negative regulation of actin filament depolymerization
|
GO:0030835 |
5 |
0.053
|
|
|
|
stem cell differentiation
|
GO:0048863 |
93 |
0.053
|
|
|
|
regulation of reactive oxygen species biosynthetic process
|
GO:1903426 |
3 |
0.053
|
|
|
|
mitotic spindle elongation
|
GO:0000022 |
4 |
0.053
|
|
|
|
actin filament bundle organization
|
GO:0061572 |
54 |
0.053
|
|
|
|
neuron remodeling
|
GO:0016322 |
2 |
0.053
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.053
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.053
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.052
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.052
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.052
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.052
|
|
|
|
inflammatory response
|
GO:0006954 |
79 |
0.052
|
|
|
|
bone development
|
GO:0060348 |
26 |
0.051
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.051
|
|
|
|
hormone biosynthetic process
|
GO:0042446 |
22 |
0.050
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.050
|
|
|
|
regulation of myeloid leukocyte mediated immunity
|
GO:0002886 |
4 |
0.050
|
|
|
|
negative regulation of notch signaling pathway
|
GO:0045746 |
10 |
0.050
|
|
|
|
positive regulation of tor signaling
|
GO:0032008 |
11 |
0.050
|
|
|
|
reproductive structure development
|
GO:0048608 |
55 |
0.050
|
|
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.050
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.049
|
|
|
|
wound healing
|
GO:0042060 |
115 |
0.049
|
|
|
|
programmed cell death in response to reactive oxygen species
|
GO:0097468 |
4 |
0.049
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.049
|
Mouse |
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.049
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.049
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.049
|
Human |
|
|
positive regulation of cytokine secretion
|
GO:0050715 |
42 |
0.049
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.049
|
|
|
|
cellular senescence
|
GO:0090398 |
34 |
0.048
|
|
|
|
actin cytoskeleton reorganization
|
GO:0031532 |
37 |
0.048
|
|
|
|
positive regulation of cell cycle process
|
GO:0090068 |
106 |
0.048
|
|
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.047
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.047
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.047
|
|
|
|
long term synaptic potentiation
|
GO:0060291 |
1 |
0.047
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.047
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.047
|
Fly |
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.046
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.046
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.046
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.045
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.045
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.045
|
|
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.045
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
11 |
0.045
|
|
|
|
axonogenesis
|
GO:0007409 |
31 |
0.045
|
Fly |
|
|
negative regulation of blood coagulation
|
GO:0030195 |
22 |
0.045
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.045
|
Fly |
|
|
regulation of adherens junction organization
|
GO:1903391 |
21 |
0.044
|
|
