Homo sapiens

20 known processes

SPC25

SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)

(Aliases: MGC22228,SPBC25,hSpc25)

SPC25 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sister chromatid segregation GO:0000819 54 0.503
regulation of cell cycle GO:0051726 393 0.482
regulation of cell cycle process GO:0010564 266 0.392
mitotic cell cycle process GO:1903047 286 0.360
mitotic nuclear division GO:0007067 119 0.320
nuclear division GO:0000280 128 0.307
organelle fission GO:0048285 149 0.298
attachment of spindle microtubules to kinetochore GO:0008608 17 0.283
circulatory system development GO:0072359 262 0.216
maintenance of location in cell GO:0051651 62 0.208
post embryonic development GO:0009791 2 0.175
mitotic sister chromatid segregation GO:0000070 53 0.160
protein catabolic process GO:0030163 325 0.132
maintenance of protein location GO:0045185 57 0.128
nucleus localization GO:0051647 1 0.127
regulation of proteolysis GO:0030162 293 0.117
cellular macromolecule catabolic process GO:0044265 380 0.117
single organism cellular localization GO:1902580 332 0.107
protein processing GO:0016485 226 0.107
negative regulation of programmed cell death GO:0043069 321 0.101
nucleoside triphosphate metabolic process GO:0009141 422 0.101
regulation of kinase activity GO:0043549 314 0.098
negative regulation of cell cycle GO:0045786 193 0.094
regulation of mitotic sister chromatid segregation GO:0033047 27 0.091
regulation of mitosis GO:0007088 63 0.089
regulation of protein catabolic process GO:0042176 155 0.086
positive regulation of organelle organization GO:0010638 195 0.084
purine nucleoside catabolic process GO:0006152 398 0.083
protein maturation GO:0051604 233 0.079
ribonucleotide catabolic process GO:0009261 405 0.077
nucleoside monophosphate catabolic process GO:0009125 159 0.073
nucleoside triphosphate catabolic process GO:0009143 394 0.072
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.070
regulation of mitotic cell cycle GO:0007346 189 0.067
organophosphate catabolic process GO:0046434 430 0.067
regulation of meiotic cell cycle GO:0051445 4 0.065
regulation of cell cycle phase transition GO:1901987 126 0.063
microtubule anchoring GO:0034453 24 0.063
positive regulation of catabolic process GO:0009896 310 0.058
positive regulation of cell cycle GO:0045787 140 0.057
nucleotide catabolic process GO:0009166 408 0.057
protein localization to organelle GO:0033365 280 0.054
ribonucleoside triphosphate catabolic process GO:0009203 391 0.051
regulation of protein processing GO:0070613 150 0.051
regulation of cellular component movement GO:0051270 334 0.050
heart development GO:0007507 95 0.050
cell cycle phase transition GO:0044770 173 0.049
cell division GO:0051301 168 0.048
positive regulation of protein phosphorylation GO:0001934 313 0.047
regulation of cell division GO:0051302 116 0.046
chromosome segregation GO:0007059 114 0.045
ribonucleoside catabolic process GO:0042454 406 0.045
nucleoside phosphate catabolic process GO:1901292 412 0.045
female gamete generation GO:0007292 2 0.045
nucleoside monophosphate metabolic process GO:0009123 191 0.045
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.044
mitotic cell cycle phase transition GO:0044772 162 0.044
ribonucleoside triphosphate metabolic process GO:0009199 412 0.042
protein localization to chromosome centromeric region GO:0071459 12 0.042
mitotic cell cycle GO:0000278 326 0.041
microtubule cytoskeleton organization GO:0000226 176 0.040
negative regulation of mitotic cell cycle GO:0045930 102 0.040
spindle assembly checkpoint GO:0071173 17 0.039
negative regulation of cell death GO:0060548 345 0.039
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.039
ribonucleoside monophosphate catabolic process GO:0009158 158 0.038
purine nucleoside triphosphate catabolic process GO:0009146 392 0.038
proteasomal protein catabolic process GO:0010498 176 0.037
mitotic sister chromatid separation GO:0051306 18 0.037
attachment of mitotic spindle microtubules to kinetochore GO:0051315 3 0.037
modification dependent protein catabolic process GO:0019941 209 0.037
purine ribonucleoside metabolic process GO:0046128 437 0.035
atp metabolic process GO:0046034 176 0.034
peptidyl serine phosphorylation GO:0018105 101 0.034
mitotic cell cycle checkpoint GO:0007093 68 0.034
negative regulation of cellular protein metabolic process GO:0032269 353 0.033
regulation of protein kinase activity GO:0045859 289 0.033
modification dependent macromolecule catabolic process GO:0043632 212 0.033
vesicle mediated transport GO:0016192 371 0.033
cell cycle checkpoint GO:0000075 117 0.033
regulation of transferase activity GO:0051338 355 0.033
positive regulation of cell division GO:0051781 59 0.032
purine nucleoside triphosphate metabolic process GO:0009144 412 0.032
negative regulation of protein maturation GO:1903318 142 0.032
regulation of cellular ketone metabolic process GO:0010565 50 0.031
embryo development GO:0009790 123 0.031
cellular protein complex assembly GO:0043623 188 0.031
regulation of protein localization GO:0032880 296 0.030
response to abiotic stimulus GO:0009628 336 0.030
ribonucleoside monophosphate metabolic process GO:0009161 187 0.030
maintenance of location GO:0051235 112 0.030
cellular ketone metabolic process GO:0042180 80 0.030
apoptotic signaling pathway GO:0097190 268 0.029
negative regulation of protein metabolic process GO:0051248 391 0.029
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.028
regulation of cellular amine metabolic process GO:0033238 11 0.028
nucleoside catabolic process GO:0009164 408 0.028
tissue regeneration GO:0042246 3 0.028
intrinsic apoptotic signaling pathway GO:0097193 127 0.028
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.027
negative regulation of cell cycle process GO:0010948 121 0.027
positive regulation of mitosis GO:0045840 25 0.027
positive regulation of hydrolase activity GO:0051345 331 0.027
cardiovascular system development GO:0072358 262 0.027
positive regulation of cellular catabolic process GO:0031331 284 0.026
cell activation GO:0001775 213 0.025
male meiosis GO:0007140 1 0.025
negative regulation of cell cycle phase transition GO:1901988 89 0.025
cellular amino acid metabolic process GO:0006520 116 0.025
cellular protein catabolic process GO:0044257 261 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.025
negative regulation of cellular component organization GO:0051129 235 0.024
purine ribonucleotide catabolic process GO:0009154 404 0.024
regulation of mitotic cell cycle phase transition GO:1901990 118 0.024
positive regulation of programmed cell death GO:0043068 249 0.024
regulation of purine nucleotide metabolic process GO:1900542 264 0.024
nervous system development GO:0007399 293 0.024
response to oxygen containing compound GO:1901700 369 0.023
positive regulation of phosphorylation GO:0042327 394 0.023
regulation of cell differentiation GO:0045595 393 0.023
purine nucleoside monophosphate metabolic process GO:0009126 186 0.023
purine nucleotide catabolic process GO:0006195 405 0.022
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.022
regulation of cellular amino acid metabolic process GO:0006521 6 0.022
single organism reproductive process GO:0044702 98 0.022
meiotic chromosome segregation GO:0045132 4 0.022
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
posttranscriptional regulation of gene expression GO:0010608 213 0.021
reproduction GO:0000003 63 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.020
atp catabolic process GO:0006200 157 0.020
organelle localization GO:0051640 84 0.020
positive regulation of transferase activity GO:0051347 227 0.020
organelle assembly GO:0070925 176 0.020
protein dna complex subunit organization GO:0071824 80 0.019
developmental process involved in reproduction GO:0003006 66 0.019
establishment of cell polarity GO:0030010 22 0.019
microtubule based process GO:0007017 210 0.019
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.019
chromosome separation GO:0051304 23 0.019
spindle organization GO:0007051 53 0.019
glycosyl compound catabolic process GO:1901658 413 0.018
positive regulation of apoptotic process GO:0043065 246 0.018
mitotic spindle assembly checkpoint GO:0007094 14 0.018
reproductive system development GO:0061458 56 0.018
establishment of spindle orientation GO:0051294 9 0.018
cellular response to radiation GO:0071478 65 0.018
regeneration GO:0031099 4 0.018
regulation of attachment of spindle microtubules to kinetochore GO:0051988 9 0.018
purine ribonucleoside catabolic process GO:0046130 398 0.018
purine containing compound catabolic process GO:0072523 411 0.018
cellular macromolecular complex assembly GO:0034622 324 0.018
reproductive structure development GO:0048608 55 0.018
regulation of protein maturation GO:1903317 150 0.018
positive regulation of cell proliferation GO:0008284 301 0.018
anatomical structure formation involved in morphogenesis GO:0048646 284 0.018
positive regulation of protein kinase activity GO:0045860 190 0.018
oogenesis GO:0048477 2 0.018
establishment of organelle localization GO:0051656 59 0.018
immune response GO:0006955 307 0.018
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.018
regulation of cell motility GO:2000145 299 0.017
cellular amine metabolic process GO:0044106 41 0.017
multicellular organismal aging GO:0010259 3 0.017
nuclear migration GO:0007097 1 0.017
blastocyst development GO:0001824 3 0.017
establishment of nucleus localization GO:0040023 1 0.017
negative regulation of protein modification process GO:0031400 200 0.017
cellular lipid metabolic process GO:0044255 303 0.017
single organism membrane organization GO:0044802 268 0.016
dna repair GO:0006281 198 0.016
negative regulation of phosphate metabolic process GO:0045936 267 0.016
negative regulation of sister chromatid segregation GO:0033046 17 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.016
regulation of binding GO:0051098 111 0.016
reproductive process GO:0022414 106 0.016
microtubule organizing center organization GO:0031023 62 0.016
ubiquitin dependent protein catabolic process GO:0006511 206 0.016
cell development GO:0048468 328 0.016
growth GO:0040007 202 0.016
negative regulation of organelle organization GO:0010639 126 0.016
negative regulation of apoptotic process GO:0043066 316 0.016
regulation of cellular component biogenesis GO:0044087 281 0.015
regulation of chromosome segregation GO:0051983 44 0.015
positive regulation of cellular component organization GO:0051130 376 0.015
regulation of proteasomal protein catabolic process GO:0061136 87 0.015
negative regulation of protein processing GO:0010955 142 0.015
regulation of endopeptidase activity GO:0052548 170 0.015
positive regulation of cell death GO:0010942 263 0.015
leukocyte activation GO:0045321 164 0.015
endocytosis GO:0006897 159 0.014
protein oligomerization GO:0051259 173 0.014
regulation of locomotion GO:0040012 329 0.014
regulation of mitotic sister chromatid separation GO:0010965 27 0.014
negative regulation of cellular protein catabolic process GO:1903363 38 0.014
negative regulation of catabolic process GO:0009895 104 0.014
response to radiation GO:0009314 151 0.014
protein depolymerization GO:0051261 30 0.014
cell fate determination GO:0001709 3 0.014
cellular response to dna damage stimulus GO:0006974 379 0.014
establishment of spindle localization GO:0051293 12 0.014
positive regulation of cell cycle process GO:0090068 106 0.014
spermatid differentiation GO:0048515 4 0.014
cytokinesis GO:0000910 96 0.013
positive regulation of kinase activity GO:0033674 204 0.013
amine metabolic process GO:0009308 44 0.013
negative regulation of intracellular signal transduction GO:1902532 183 0.013
biological adhesion GO:0022610 331 0.013
positive regulation of wnt signaling pathway GO:0030177 54 0.013
ras protein signal transduction GO:0007265 73 0.013
regulation of cellular response to stress GO:0080135 244 0.013
positive regulation of proteolysis GO:0045862 142 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.012
regulation of protein serine threonine kinase activity GO:0071900 179 0.012
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.012
negative regulation of cellular amine metabolic process GO:0033239 3 0.012
protein ubiquitination GO:0016567 314 0.012
negative regulation of phosphorylation GO:0042326 174 0.012
neurogenesis GO:0022008 169 0.012
metaphase plate congression GO:0051310 18 0.012
cell cell signaling GO:0007267 155 0.012
histone modification GO:0016570 251 0.012
defense response GO:0006952 315 0.012
dna recombination GO:0006310 77 0.011
chromatin modification GO:0016568 298 0.011
enzyme linked receptor protein signaling pathway GO:0007167 303 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.011
determination of adult lifespan GO:0008340 2 0.011
intracellular protein transport GO:0006886 270 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
neural crest cell migration GO:0001755 2 0.011
regulation of wnt signaling pathway GO:0030111 123 0.011
regulation of purine nucleotide catabolic process GO:0033121 205 0.011
regulation of cellular protein catabolic process GO:1903362 96 0.011
wnt signaling pathway GO:0016055 156 0.011
cellular component morphogenesis GO:0032989 314 0.011
reciprocal meiotic recombination GO:0007131 4 0.011
regulation of nucleotide metabolic process GO:0006140 269 0.011
regulation of chromosome organization GO:0033044 103 0.010
endomembrane system organization GO:0010256 196 0.010
centrosome separation GO:0051299 3 0.010
negative regulation of protein phosphorylation GO:0001933 140 0.010
cytoplasmic transport GO:0016482 379 0.010
positive regulation of mitotic sister chromatid separation GO:1901970 6 0.010
cellular homeostasis GO:0019725 196 0.010

SPC25 disease predictions

Disease DO term ID Size Probability Func Analog Org
physical disorder DOID:0080015 41 0.050
congenital nervous system abnormality DOID:2490 21 0.050
disease of cellular proliferation DOID:14566 174 0.033