Homo sapiens

71 known processes

SQSTM1

sequestosome 1

(Aliases: p60,p62,p62B,PDB3,OSIL,A170,ZIP3)

SQSTM1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
autophagy GO:0006914 88 1.000
regulation of i kappab kinase nf kappab signaling GO:0043122 162 1.000
i kappab kinase nf kappab signaling GO:0007249 166 1.000
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.999
protein catabolic process GO:0030163 325 0.998
response to other organism GO:0051707 261 0.998
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.998
regulation of apoptotic signaling pathway GO:2001233 175 0.997
positive regulation of cellular catabolic process GO:0031331 284 0.997
macroautophagy GO:0016236 39 0.996
anatomical structure formation involved in morphogenesis GO:0048646 284 0.994
apoptotic signaling pathway GO:0097190 268 0.993
response to bacterium GO:0009617 144 0.992
positive regulation of autophagy GO:0010508 24 0.992
purine ribonucleoside catabolic process GO:0046130 398 0.991
purine nucleoside triphosphate catabolic process GO:0009146 392 0.988
regulation of autophagy GO:0010506 52 0.988
cellular response to nutrient levels GO:0031669 69 0.987
ubiquitin dependent protein catabolic process GO:0006511 206 0.984
positive regulation of mapk cascade GO:0043410 190 0.983
determination of adult lifespan GO:0008340 2 0.983
defense response to bacterium GO:0042742 63 0.982
cellular response to starvation GO:0009267 58 0.982
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.980
positive regulation of apoptotic process GO:0043065 246 0.977
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.977
autophagic vacuole assembly GO:0000045 19 0.974
protein ubiquitination GO:0016567 314 0.972
regulation of stress activated mapk cascade GO:0032872 84 0.971
neural tube formation GO:0001841 3 0.971
cellular component disassembly GO:0022411 92 0.970
activation of immune response GO:0002253 114 0.970
intrinsic apoptotic signaling pathway GO:0097193 127 0.968
defense response GO:0006952 315 0.967
positive regulation of apoptotic signaling pathway GO:2001235 70 0.967
regulation of cellular response to stress GO:0080135 244 0.965
negative regulation of programmed cell death GO:0043069 321 0.965
response to starvation GO:0042594 59 0.964
positive regulation of protein phosphorylation GO:0001934 313 0.964
Rat
purine ribonucleotide catabolic process GO:0009154 404 0.959
multicellular organismal aging GO:0010259 3 0.951
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.951
positive regulation of programmed cell death GO:0043068 249 0.950
negative regulation of apoptotic process GO:0043066 316 0.947
purine nucleoside triphosphate metabolic process GO:0009144 412 0.946
endosomal transport GO:0016197 129 0.942
negative regulation of cell death GO:0060548 345 0.932
regulation of protein kinase activity GO:0045859 289 0.931
regulation of endothelial cell apoptotic process GO:2000351 24 0.930
response to inorganic substance GO:0010035 127 0.927
regulation of cellular ketone metabolic process GO:0010565 50 0.924
negative regulation of cellular component organization GO:0051129 235 0.922
response to external biotic stimulus GO:0043207 261 0.919
protein modification by small protein conjugation GO:0032446 342 0.917
response to biotic stimulus GO:0009607 276 0.917
regulation of peptidase activity GO:0052547 180 0.910
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.909
protein processing GO:0016485 226 0.907
positive regulation of response to external stimulus GO:0032103 88 0.904
negative regulation of multicellular organismal process GO:0051241 317 0.903
growth GO:0040007 202 0.902
response to extracellular stimulus GO:0009991 85 0.902
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.901
regulation of mapk cascade GO:0043408 262 0.890
nucleoside catabolic process GO:0009164 408 0.890
cellular response to tumor necrosis factor GO:0071356 63 0.884
cellular response to extracellular stimulus GO:0031668 72 0.884
positive regulation of catabolic process GO:0009896 310 0.868
cytoplasmic transport GO:0016482 379 0.865
ribonucleotide catabolic process GO:0009261 405 0.861
regulation of transferase activity GO:0051338 355 0.853
regulation of proteolysis GO:0030162 293 0.849
cellular response to external stimulus GO:0071496 111 0.847
positive regulation of phosphorylation GO:0042327 394 0.847
Rat
positive regulation of immune response GO:0050778 159 0.841
cellular protein catabolic process GO:0044257 261 0.840
nucleoside triphosphate metabolic process GO:0009141 422 0.840
cellular macromolecule catabolic process GO:0044265 380 0.838
positive regulation of transferase activity GO:0051347 227 0.836
cellular ketone metabolic process GO:0042180 80 0.836
regulation of immune response GO:0050776 201 0.834
positive regulation of protein kinase activity GO:0045860 190 0.833
response to nutrient levels GO:0031667 81 0.831
nucleoside phosphate catabolic process GO:1901292 412 0.831
fatty acid catabolic process GO:0009062 29 0.820
proteasomal protein catabolic process GO:0010498 176 0.809
defense response to other organism GO:0098542 129 0.804
immune response GO:0006955 307 0.802
extrinsic apoptotic signaling pathway GO:0097191 119 0.799
positive regulation of cell death GO:0010942 263 0.799
cellular component morphogenesis GO:0032989 314 0.795
endothelial cell apoptotic process GO:0072577 26 0.786
regulation of cell differentiation GO:0045595 393 0.776
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.754
ribonucleoside catabolic process GO:0042454 406 0.739
cellular carbohydrate metabolic process GO:0044262 84 0.737
striated muscle cell differentiation GO:0051146 43 0.733
epithelial tube morphogenesis GO:0060562 38 0.725
negative regulation of protein metabolic process GO:0051248 391 0.722
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.721
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.718
macromolecular complex disassembly GO:0032984 60 0.716
regulation of endopeptidase activity GO:0052548 170 0.711
protein oligomerization GO:0051259 173 0.704
Rat
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.701
negative regulation of developmental process GO:0051093 247 0.695
regulation of defense response GO:0031347 154 0.685
regulation of response to external stimulus GO:0032101 222 0.684
innate immune response GO:0045087 178 0.650
single organism cellular localization GO:1902580 332 0.648
regulation of oxidative stress induced intrinsic apoptotic signaling pathway GO:1902175 16 0.639
modification dependent protein catabolic process GO:0019941 209 0.639
purine containing compound catabolic process GO:0072523 411 0.636
purine nucleotide catabolic process GO:0006195 405 0.632
flavonoid metabolic process GO:0009812 8 0.627
organelle localization GO:0051640 84 0.626
signal transduction by phosphorylation GO:0023014 297 0.624
regulation of kinase activity GO:0043549 314 0.620
protein maturation GO:0051604 233 0.617
peptidyl serine phosphorylation GO:0018105 101 0.611
response to cytokine GO:0034097 232 0.593
immune response activating signal transduction GO:0002757 90 0.587
negative regulation of apoptotic signaling pathway GO:2001234 97 0.587
cellular response to oxidative stress GO:0034599 85 0.573
purine ribonucleoside metabolic process GO:0046128 437 0.565
activation of nf kappab inducing kinase activity GO:0007250 9 0.564
tube development GO:0035295 125 0.563
fatty acid metabolic process GO:0006631 115 0.561
regulation of protein serine threonine kinase activity GO:0071900 179 0.560
activation of protein kinase activity GO:0032147 90 0.558
regulation of cytokine production GO:0001817 232 0.544
guanosine containing compound catabolic process GO:1901069 239 0.544
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.539
immune response regulating signaling pathway GO:0002764 97 0.534
gtp catabolic process GO:0006184 237 0.527
negative regulation of protein catabolic process GO:0042177 59 0.520
hematopoietic or lymphoid organ development GO:0048534 186 0.516
ribonucleoside triphosphate metabolic process GO:0009199 412 0.512
cellular response to cytokine stimulus GO:0071345 181 0.509
regulation of proteasomal protein catabolic process GO:0061136 87 0.499
regulation of cysteine type endopeptidase activity GO:2000116 127 0.499
negative regulation of protein maturation GO:1903318 142 0.495
cytokine production GO:0001816 247 0.495
protein complex disassembly GO:0043241 52 0.492
cellular component assembly involved in morphogenesis GO:0010927 73 0.484
ras protein signal transduction GO:0007265 73 0.482
muscle cell development GO:0055001 29 0.475
negative regulation of intracellular signal transduction GO:1902532 183 0.463
regulation of cellular response to growth factor stimulus GO:0090287 76 0.462
tissue homeostasis GO:0001894 63 0.455
cell type specific apoptotic process GO:0097285 125 0.441
regulation of protein catabolic process GO:0042176 155 0.437
apoptotic mitochondrial changes GO:0008637 57 0.432
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.426
regulation of cytokine production involved in immune response GO:0002718 22 0.424
system process GO:0003008 349 0.416
organophosphate catabolic process GO:0046434 430 0.409
negative regulation of cell differentiation GO:0045596 171 0.406
nucleoside triphosphate catabolic process GO:0009143 394 0.403
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.403
small molecule catabolic process GO:0044282 92 0.398
ribose phosphate biosynthetic process GO:0046390 82 0.393
positive regulation of kinase activity GO:0033674 204 0.388
immune response activating cell surface receptor signaling pathway GO:0002429 45 0.388
actin filament organization GO:0007015 128 0.387
cell development GO:0048468 328 0.385
vacuole organization GO:0007033 44 0.380
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.377
tissue morphogenesis GO:0048729 96 0.373
single organism membrane organization GO:0044802 268 0.368
regulation of cellular response to oxidative stress GO:1900407 26 0.367
purine nucleoside monophosphate metabolic process GO:0009126 186 0.365
positive regulation of developmental process GO:0051094 314 0.355
positive regulation of peptidase activity GO:0010952 88 0.353
morphogenesis of an epithelium GO:0002009 60 0.352
positive regulation of immune system process GO:0002684 283 0.349
endothelial cell migration GO:0043542 86 0.348
protein depolymerization GO:0051261 30 0.346
mitochondrion organization GO:0007005 156 0.346
antigen receptor mediated signaling pathway GO:0050851 38 0.345
enzyme linked receptor protein signaling pathway GO:0007167 303 0.328
positive regulation of hydrolase activity GO:0051345 331 0.327
protein targeting GO:0006605 187 0.320
lymphocyte proliferation GO:0046651 70 0.318
guanosine containing compound metabolic process GO:1901068 244 0.317
protein polyubiquitination GO:0000209 110 0.317
regulation of cell growth GO:0001558 135 0.316
regulation of response to oxidative stress GO:1902882 26 0.314
positive regulation of nucleoside metabolic process GO:0045979 186 0.313
regulation of map kinase activity GO:0043405 108 0.312
cell morphogenesis GO:0000902 296 0.306
ribonucleoside triphosphate catabolic process GO:0009203 391 0.306
toll like receptor 2 signaling pathway GO:0034134 4 0.304
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.299
cellular protein complex disassembly GO:0043624 36 0.297
regulation of purine nucleotide metabolic process GO:1900542 264 0.296
nucleotide catabolic process GO:0009166 408 0.295
cell junction maintenance GO:0034331 4 0.291
epithelium development GO:0060429 227 0.290
cellular response to oxygen levels GO:0071453 55 0.287
embryonic epithelial tube formation GO:0001838 4 0.284
cell growth GO:0016049 160 0.278
negative regulation of catabolic process GO:0009895 104 0.278
regulation of cd40 signaling pathway GO:2000348 3 0.278
regulation of purine nucleotide catabolic process GO:0033121 205 0.277
circulatory system development GO:0072359 262 0.275
nuclear transport GO:0051169 179 0.273
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.267
regulation of gtpase activity GO:0043087 180 0.259
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.259
golgi ribbon formation GO:0090161 3 0.259
response to growth factor GO:0070848 205 0.251
cellular response to growth factor stimulus GO:0071363 197 0.249
positive regulation of cellular amine metabolic process GO:0033240 7 0.249
negative regulation of cytoskeleton organization GO:0051494 45 0.248
organelle assembly GO:0070925 176 0.247
protein targeting to nucleus GO:0044744 104 0.246
neurogenesis GO:0022008 169 0.236
developmental process involved in reproduction GO:0003006 66 0.236
regulation of t cell cytokine production GO:0002724 10 0.235
positive regulation of proteolysis GO:0045862 142 0.229
cell projection organization GO:0030030 252 0.228
spinal cord development GO:0021510 4 0.225
negative regulation of ossification GO:0030279 21 0.221
response to decreased oxygen levels GO:0036293 96 0.219
lymphocyte homeostasis GO:0002260 4 0.218
gtp metabolic process GO:0046039 239 0.217
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.216
mapk cascade GO:0000165 288 0.213
zymogen activation GO:0031638 70 0.209
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.208
neural tube development GO:0021915 9 0.205
negative regulation of organelle organization GO:0010639 126 0.204
morphogenesis of embryonic epithelium GO:0016331 4 0.202
response to abiotic stimulus GO:0009628 336 0.200
regulation of anatomical structure morphogenesis GO:0022603 286 0.200
anterior posterior axis specification GO:0009948 2 0.198
lipid oxidation GO:0034440 33 0.197
cellular lipid metabolic process GO:0044255 303 0.197
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.195
positive regulation of stress activated mapk cascade GO:0032874 60 0.192
regulation of glucose metabolic process GO:0010906 28 0.190
regulation of transmembrane transport GO:0034762 139 0.187
cellular response to oxygen containing compound GO:1901701 276 0.187
lipid catabolic process GO:0016042 84 0.186
positive regulation of secretion by cell GO:1903532 108 0.183
cell activation GO:0001775 213 0.183
response to fungus GO:0009620 4 0.182
stress activated mapk cascade GO:0051403 93 0.180
cellular lipid catabolic process GO:0044242 65 0.177
negative regulation of protein processing GO:0010955 142 0.177
lymphocyte apoptotic process GO:0070227 20 0.175
establishment of organelle localization GO:0051656 59 0.174
regulation of anatomical structure size GO:0090066 101 0.172
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.172
interspecies interaction between organisms GO:0044419 156 0.171
microtubule cytoskeleton organization GO:0000226 176 0.171
response to organonitrogen compound GO:0010243 156 0.169
oxidation reduction process GO:0055114 396 0.168
organonitrogen compound biosynthetic process GO:1901566 200 0.166
necrotic cell death GO:0070265 21 0.164
negative regulation of cellular response to oxidative stress GO:1900408 18 0.162
response to oxygen containing compound GO:1901700 369 0.162
purine nucleoside catabolic process GO:0006152 398 0.162
regulation of protein localization GO:0032880 296 0.162
negative regulation of collateral sprouting GO:0048671 1 0.161
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.160
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.159
regulation of cellular component biogenesis GO:0044087 281 0.159
immune effector process GO:0002252 159 0.158
leukocyte apoptotic process GO:0071887 31 0.158
regulation of cellular protein catabolic process GO:1903362 96 0.157
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.155
carbohydrate metabolic process GO:0005975 207 0.155
regulation of protein ubiquitination GO:0031396 95 0.153
positive regulation of nucleotide metabolic process GO:0045981 230 0.153
positive regulation of map kinase activity GO:0043406 80 0.152
aging GO:0007568 66 0.150
protein localization to organelle GO:0033365 280 0.149
regulation of ion transmembrane transport GO:0034765 132 0.149
negative regulation of cellular protein metabolic process GO:0032269 353 0.148
negative regulation of actin filament polymerization GO:0030837 10 0.144
negative regulation of protein modification process GO:0031400 200 0.141
actin filament bundle organization GO:0061572 54 0.139
positive regulation of gtp catabolic process GO:0033126 166 0.137
regulation of macroautophagy GO:0016241 19 0.136
regulation of ossification GO:0030278 58 0.136
primary neural tube formation GO:0014020 3 0.134
glucose metabolic process GO:0006006 45 0.133
establishment of protein localization to vacuole GO:0072666 8 0.133
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.132
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.128
ribonucleoprotein complex assembly GO:0022618 78 0.127
response to metal ion GO:0010038 84 0.126
covalent chromatin modification GO:0016569 254 0.126
nik nf kappab signaling GO:0038061 12 0.125
multicellular organismal homeostasis GO:0048871 67 0.123
negative regulation of proteolysis GO:0045861 132 0.123
segmentation GO:0035282 4 0.122
negative regulation of kinase activity GO:0033673 106 0.122
regulation of transporter activity GO:0032409 82 0.120
protein k48 linked ubiquitination GO:0070936 38 0.120
regulation of blood vessel endothelial cell migration GO:0043535 30 0.119
organophosphate biosynthetic process GO:0090407 163 0.116
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.116
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.115
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.115
positive regulation of release of cytochrome c from mitochondria GO:0090200 18 0.114
rab protein signal transduction GO:0032482 4 0.114
neuron development GO:0048666 113 0.114
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 15 0.114
establishment of protein localization to organelle GO:0072594 172 0.113
negative regulation of endothelial cell apoptotic process GO:2000352 16 0.113
membrane organization GO:0061024 292 0.111
lipid metabolic process GO:0006629 381 0.110
lipid modification GO:0030258 84 0.109
positive regulation of t cell cytokine production GO:0002726 4 0.108
positive regulation of cellular component movement GO:0051272 181 0.107
brain development GO:0007420 97 0.107
erythrocyte differentiation GO:0030218 28 0.106
fat cell differentiation GO:0045444 32 0.106
leukocyte proliferation GO:0070661 74 0.105
negative regulation of cell growth GO:0030308 83 0.104
single organism reproductive process GO:0044702 98 0.104
microtubule based process GO:0007017 210 0.103
muscle cell differentiation GO:0042692 63 0.103
positive regulation of jnk cascade GO:0046330 52 0.103
regulation of neurotrophin trk receptor signaling pathway GO:0051386 2 0.103
protein autophosphorylation GO:0046777 123 0.102
activation of jnkk activity GO:0007256 1 0.101
actin filament based process GO:0030029 224 0.100
regulation of ras gtpase activity GO:0032318 128 0.100
regulation of fat cell differentiation GO:0045598 23 0.100
actomyosin structure organization GO:0031032 59 0.100
cell death in response to oxidative stress GO:0036473 29 0.100
ribonucleoside monophosphate metabolic process GO:0009161 187 0.099
leukocyte mediated immunity GO:0002443 59 0.099
positive regulation of response to extracellular stimulus GO:0032106 14 0.098
protein k63 linked deubiquitination GO:0070536 21 0.098
response to tumor necrosis factor GO:0034612 76 0.096
negative regulation of cellular amine metabolic process GO:0033239 3 0.095
response to hormone GO:0009725 175 0.094
regulation of osteoblast differentiation GO:0045667 38 0.094
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.093
heart development GO:0007507 95 0.093
cellular response to reactive oxygen species GO:0034614 50 0.092
mononuclear cell proliferation GO:0032943 71 0.092
cellular response to decreased oxygen levels GO:0036294 51 0.091
production of molecular mediator of immune response GO:0002440 37 0.091
digestive system development GO:0055123 75 0.089
muscle cell proliferation GO:0033002 35 0.089
regulation of secretion GO:0051046 194 0.089
regulation of peptidyl serine phosphorylation GO:0033135 50 0.088
hexose metabolic process GO:0019318 55 0.087
t cell cytokine production GO:0002369 12 0.087
compound eye development GO:0048749 1 0.087
fatty acid oxidation GO:0019395 31 0.086
monocarboxylic acid catabolic process GO:0072329 37 0.086
regulation of epithelial cell migration GO:0010632 93 0.086
protein localization to nucleus GO:0034504 136 0.085
positive regulation of endothelial cell apoptotic process GO:2000353 8 0.085
regulation of leukocyte proliferation GO:0070663 67 0.084
asymmetric neuroblast division GO:0055059 1 0.084
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.082
positive regulation of jun kinase activity GO:0043507 23 0.082
positive regulation of mitochondrial fission GO:0090141 7 0.081
stress activated protein kinase signaling cascade GO:0031098 94 0.080
regulation of actin cytoskeleton organization GO:0032956 116 0.080
carboxylic acid catabolic process GO:0046395 71 0.079
c terminal protein amino acid modification GO:0018410 1 0.079
heart process GO:0003015 62 0.079
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.078
regulation of homeostatic process GO:0032844 121 0.078
t cell apoptotic process GO:0070231 12 0.077
anatomical structure homeostasis GO:0060249 100 0.077
positive regulation of transporter activity GO:0032411 32 0.077
vesicle mediated transport GO:0016192 371 0.077
response to nitrogen compound GO:1901698 184 0.077
cytokine biosynthetic process GO:0042089 37 0.077
regulation of cell activation GO:0050865 125 0.076
protein k33 linked ubiquitination GO:1990390 1 0.076
establishment of cell polarity GO:0030010 22 0.076
cellular homeostasis GO:0019725 196 0.074
embryonic organ development GO:0048568 36 0.074
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.074
negative regulation of striated muscle cell apoptotic process GO:0010664 2 0.074
reactive oxygen species metabolic process GO:0072593 75 0.074
modification dependent macromolecule catabolic process GO:0043632 212 0.074
glycosyl compound catabolic process GO:1901658 413 0.073
organic hydroxy compound metabolic process GO:1901615 147 0.073
nucleoside monophosphate metabolic process GO:0009123 191 0.072
negative regulation of protein phosphorylation GO:0001933 140 0.072
immune system development GO:0002520 195 0.072
glycogen metabolic process GO:0005977 22 0.071
embryonic placenta development GO:0001892 1 0.071
monocarboxylic acid transport GO:0015718 32 0.070
negative regulation of catalytic activity GO:0043086 335 0.070
positive regulation of mitochondrion organization GO:0010822 30 0.069
negative regulation of cell projection organization GO:0031345 22 0.069
purine ribonucleotide biosynthetic process GO:0009152 79 0.068
regulation of dephosphorylation GO:0035303 96 0.068
regulation of collateral sprouting GO:0048670 2 0.067
positive regulation of necrotic cell death GO:0010940 4 0.067
embryo development ending in birth or egg hatching GO:0009792 34 0.066
protein localization to membrane GO:0072657 160 0.064
regulation of oxidative stress induced cell death GO:1903201 24 0.063
embryonic morphogenesis GO:0048598 85 0.063
positive regulation of endothelial cell migration GO:0010595 39 0.063
homeostasis of number of cells GO:0048872 40 0.062
interleukin 1 beta production GO:0032611 22 0.061
epithelial cell proliferation GO:0050673 128 0.061
fatty acid beta oxidation GO:0006635 22 0.060
regulation of immune effector process GO:0002697 91 0.060
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.060
regulation of protein processing GO:0070613 150 0.059
chromatin assembly GO:0031497 61 0.059
organic acid transport GO:0015849 65 0.058
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.058
intracellular receptor signaling pathway GO:0030522 104 0.057
myeloid cell homeostasis GO:0002262 34 0.057
negative regulation of multi organism process GO:0043901 92 0.057
head development GO:0060322 108 0.057
negative regulation of transferase activity GO:0051348 124 0.057
regulation of growth GO:0040008 165 0.057
regulation of cell migration GO:0030334 289 0.056
activation of innate immune response GO:0002218 55 0.056
regeneration GO:0031099 4 0.056
positive regulation of p38mapk cascade GO:1900745 8 0.056
intermediate filament cytoskeleton organization GO:0045104 17 0.056
positive regulation of gliogenesis GO:0014015 4 0.055
response to virus GO:0009615 126 0.054
regulation of tumor necrosis factor mediated signaling pathway GO:0010803 12 0.053
interleukin 6 production GO:0032635 37 0.053
regulation of adaptive immune response GO:0002819 33 0.053
t cell mediated immunity GO:0002456 25 0.053
ameboidal type cell migration GO:0001667 135 0.052
regulation of lipid metabolic process GO:0019216 96 0.051
t cell receptor signaling pathway GO:0050852 21 0.051
regulation of binding GO:0051098 111 0.051
regulation of gtp catabolic process GO:0033124 180 0.050
cell adhesion GO:0007155 325 0.050
positive regulation of fatty acid metabolic process GO:0045923 11 0.050
jnk cascade GO:0007254 80 0.050
innate immune response activating signal transduction GO:0002758 48 0.050
nucleoside phosphate biosynthetic process GO:1901293 109 0.049
neuron differentiation GO:0030182 138 0.049
regulation of production of molecular mediator of immune response GO:0002700 25 0.049
regulation of nucleoside metabolic process GO:0009118 209 0.049
protein localization to vacuole GO:0072665 11 0.048
cell aging GO:0007569 52 0.048
positive regulation of interferon beta biosynthetic process GO:0045359 4 0.047
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.047
organic acid catabolic process GO:0016054 71 0.047
translational initiation GO:0006413 48 0.047
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.047
mitotic cell cycle GO:0000278 326 0.047
cellular response to abiotic stimulus GO:0071214 117 0.047
positive regulation of cell migration GO:0030335 172 0.046
positive regulation of cell motility GO:2000147 177 0.046
positive regulation of gtpase activity GO:0043547 166 0.045
peptidyl serine modification GO:0018209 106 0.045
reproductive process GO:0022414 106 0.045
positive regulation of secretion GO:0051047 116 0.044
positive regulation of macroautophagy GO:0016239 12 0.044
regulation of leukocyte apoptotic process GO:2000106 25 0.043
actin cytoskeleton organization GO:0030036 207 0.043
regulation of t cell activation GO:0050863 77 0.043
cellular response to molecule of bacterial origin GO:0071219 62 0.043
cellular response to heat GO:0034605 14 0.042
mitochondrion degradation GO:0000422 8 0.042
regulation of cellular amino acid metabolic process GO:0006521 6 0.042
regulation of biomineral tissue development GO:0070167 31 0.042
protein targeting to vacuole GO:0006623 8 0.042
purine containing compound biosynthetic process GO:0072522 88 0.042
establishment of protein localization to membrane GO:0090150 121 0.042
lymphocyte activation GO:0046649 133 0.041
regulation of membrane potential GO:0042391 95 0.041

SQSTM1 disease predictions

Disease DO term ID Size Probability Func Analog Org
glaucoma DOID:1686 8 0.756
retinal disease DOID:5679 118 0.756
retinal degeneration DOID:8466 89 0.756
sensory system disease DOID:0050155 203 0.756
eye and adnexa disease DOID:1492 150 0.756
eye disease DOID:5614 149 0.756
nervous system disease DOID:863 431 0.756
cardiovascular system disease DOID:1287 106 0.529
musculoskeletal system disease DOID:17 223 0.176
myopathy DOID:423 104 0.176
intrinsic cardiomyopathy DOID:0060036 50 0.176
cardiomyopathy DOID:0050700 50 0.176
muscular disease DOID:0080000 114 0.176
muscle tissue disease DOID:66 113 0.176
heart disease DOID:114 68 0.176
neuropathy DOID:870 52 0.131
central nervous system disease DOID:331 186 0.100
neurodegenerative disease DOID:1289 102 0.044