|
|
interleukin 6 mediated signaling pathway
|
GO:0070102 |
7 |
1.000
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
1.000
|
|
|
|
response to peptide
|
GO:1901652 |
65 |
1.000
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
1.000
|
|
|
|
cellular response to hormone stimulus
|
GO:0032870 |
125 |
1.000
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
1.000
|
|
|
|
response to organonitrogen compound
|
GO:0010243 |
156 |
1.000
|
|
|
|
response to peptide hormone
|
GO:0043434 |
61 |
0.999
|
|
|
|
cellular response to nitrogen compound
|
GO:1901699 |
144 |
0.999
|
|
|
|
ciliary neurotrophic factor mediated signaling pathway
|
GO:0070120 |
5 |
0.999
|
|
|
|
cellular response to peptide hormone stimulus
|
GO:0071375 |
56 |
0.999
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.999
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.997
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.996
|
|
|
|
response to cytokine
|
GO:0034097 |
232 |
0.996
|
|
|
|
cellular response to peptide
|
GO:1901653 |
59 |
0.996
|
|
|
|
interleukin 27 mediated signaling pathway
|
GO:0070106 |
1 |
0.995
|
|
|
|
cellular response to organonitrogen compound
|
GO:0071417 |
124 |
0.995
|
|
|
|
interleukin 4 mediated signaling pathway
|
GO:0035771 |
3 |
0.994
|
Human |
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.993
|
Zebrafish Mouse |
|
|
interleukin 2 mediated signaling pathway
|
GO:0038110 |
3 |
0.993
|
|
|
|
response to nitrogen compound
|
GO:1901698 |
184 |
0.992
|
|
|
|
regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042516 |
18 |
0.992
|
|
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.992
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.991
|
|
|
|
jak stat cascade involved in growth hormone signaling pathway
|
GO:0060397 |
2 |
0.990
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.988
|
|
|
|
regulation of interleukin 6 mediated signaling pathway
|
GO:0070103 |
3 |
0.987
|
|
|
|
cellular response to interleukin 6
|
GO:0071354 |
14 |
0.986
|
|
|
|
oncostatin m mediated signaling pathway
|
GO:0038165 |
3 |
0.986
|
|
|
|
response to hormone
|
GO:0009725 |
175 |
0.985
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.983
|
|
|
|
leukemia inhibitory factor signaling pathway
|
GO:0048861 |
3 |
0.981
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.980
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.980
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.979
|
|
|
|
positive regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042517 |
16 |
0.979
|
|
|
|
response to interleukin 6
|
GO:0070741 |
15 |
0.977
|
|
|
|
cellular response to growth hormone stimulus
|
GO:0071378 |
10 |
0.972
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.971
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.967
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.961
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.955
|
Human Rat |
|
|
t cell activation
|
GO:0042110 |
99 |
0.953
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.953
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.952
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.952
|
|
|
|
gland development
|
GO:0048732 |
48 |
0.951
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.949
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.935
|
Human |
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.935
|
Mouse |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.931
|
|
|
|
cellular response to insulin stimulus
|
GO:0032869 |
41 |
0.930
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.926
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.923
|
|
|
|
neuron projection regeneration
|
GO:0031102 |
1 |
0.919
|
|
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.918
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.912
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.907
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.906
|
|
|
|
renal tubule development
|
GO:0061326 |
19 |
0.904
|
Human |
|
|
immune system development
|
GO:0002520 |
195 |
0.887
|
|
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.887
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.884
|
|
|
|
axon regeneration
|
GO:0031103 |
1 |
0.884
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.882
|
|
|
|
astrocyte differentiation
|
GO:0048708 |
4 |
0.879
|
Mouse |
|
|
response to insulin
|
GO:0032868 |
45 |
0.877
|
|
|
|
regulation of insulin secretion
|
GO:0050796 |
33 |
0.876
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.875
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.871
|
Rat |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.864
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.860
|
Rat |
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.859
|
Zebrafish |
|
|
negative regulation of cytokine mediated signaling pathway
|
GO:0001960 |
22 |
0.858
|
|
|
|
tyrosine phosphorylation of stat3 protein
|
GO:0042503 |
20 |
0.858
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.856
|
|
|
|
response to growth hormone
|
GO:0060416 |
11 |
0.854
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.852
|
Human |
|
|
interferon gamma mediated signaling pathway
|
GO:0060333 |
7 |
0.851
|
Human |
|
|
tyrosine phosphorylation of stat protein
|
GO:0007260 |
33 |
0.847
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.845
|
|
|
|
growth hormone receptor signaling pathway
|
GO:0060396 |
10 |
0.843
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.841
|
|
|
|
response to interleukin 4
|
GO:0070670 |
7 |
0.836
|
Human |
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.832
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.831
|
Human Mouse |
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.824
|
|
|
|
interleukin 12 mediated signaling pathway
|
GO:0035722 |
3 |
0.820
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.817
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.816
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.816
|
|
|
|
mammary gland morphogenesis
|
GO:0060443 |
2 |
0.816
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.812
|
|
|
|
response to estradiol
|
GO:0032355 |
23 |
0.812
|
|
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.801
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.801
|
Human |
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.800
|
Zebrafish Rat |
|
|
defense response to other organism
|
GO:0098542 |
129 |
0.799
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.798
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.792
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.789
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.789
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.785
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.782
|
Human Mouse |
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.781
|
|
|
|
mammary gland involution
|
GO:0060056 |
1 |
0.779
|
|
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.774
|
Human |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.772
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.772
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.767
|
|
|
|
carbohydrate transport
|
GO:0008643 |
37 |
0.763
|
|
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.761
|
|
|
|
peptide transport
|
GO:0015833 |
74 |
0.760
|
|
|
|
memory
|
GO:0007613 |
3 |
0.747
|
|
|
|
peptide secretion
|
GO:0002790 |
51 |
0.743
|
|
|
|
hexose transport
|
GO:0008645 |
30 |
0.736
|
|
|
|
negative regulation of tyrosine phosphorylation of stat3 protein
|
GO:0042518 |
2 |
0.734
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.734
|
Human Mouse |
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.733
|
|
|
|
cellular response to interferon gamma
|
GO:0071346 |
24 |
0.730
|
Human |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.728
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.723
|
Zebrafish Mouse |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.723
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.709
|
|
|
|
insulin secretion
|
GO:0030073 |
39 |
0.707
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.703
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.692
|
Zebrafish Mouse |
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.691
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.686
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.683
|
|
|
|
long term memory
|
GO:0007616 |
2 |
0.682
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.677
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.675
|
|
|
|
prostate gland morphogenesis
|
GO:0060512 |
1 |
0.674
|
|
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.671
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.670
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.665
|
|
|
|
positive regulation of peptidyl tyrosine phosphorylation
|
GO:0050731 |
85 |
0.658
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.648
|
Zebrafish Mouse |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.647
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.646
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.636
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.633
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.630
|
Rat |
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.629
|
|
|
|
cell cell signaling
|
GO:0007267 |
155 |
0.629
|
|
|
|
rhythmic behavior
|
GO:0007622 |
2 |
0.625
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.621
|
|
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.620
|
|
|
|
negative regulation of cytosolic calcium ion concentration
|
GO:0051481 |
1 |
0.619
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.618
|
|
|
|
negative regulation of interleukin 6 mediated signaling pathway
|
GO:0070104 |
2 |
0.617
|
|
|
|
circadian behavior
|
GO:0048512 |
2 |
0.617
|
|
|
|
tissue remodeling
|
GO:0048771 |
16 |
0.614
|
|
|
|
embryonic hemopoiesis
|
GO:0035162 |
4 |
0.610
|
|
|
|
activation of immune response
|
GO:0002253 |
114 |
0.609
|
|
|
|
response to interferon beta
|
GO:0035456 |
11 |
0.606
|
Human |
|
|
regulation of glucose import
|
GO:0046324 |
21 |
0.602
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.600
|
|
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.599
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.596
|
Zebrafish Mouse |
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.591
|
Zebrafish |
|
|
regulation of t cell activation
|
GO:0050863 |
77 |
0.589
|
|
|
|
insulin receptor signaling pathway
|
GO:0008286 |
23 |
0.588
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.583
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.582
|
|
|
|
histone modification
|
GO:0016570 |
251 |
0.582
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.581
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.577
|
Human |
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.575
|
|
|
|
associative learning
|
GO:0008306 |
1 |
0.575
|
|
|
|
actin filament based movement
|
GO:0030048 |
17 |
0.575
|
|
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.573
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.571
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.570
|
Human |
|
|
protein import
|
GO:0017038 |
130 |
0.568
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.568
|
Mouse |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.568
|
|
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.562
|
|
|
|
cellular response to interleukin 12
|
GO:0071349 |
3 |
0.555
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.552
|
Zebrafish |
|
|
regulation of tyrosine phosphorylation of stat protein
|
GO:0042509 |
30 |
0.551
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.551
|
|
|
|
regulation of homeostatic process
|
GO:0032844 |
121 |
0.544
|
|
|
|
positive regulation of tyrosine phosphorylation of stat protein
|
GO:0042531 |
28 |
0.539
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.538
|
|
|
|
calcium ion transmembrane transport
|
GO:0070588 |
76 |
0.536
|
|
|
|
response to estrogen
|
GO:0043627 |
47 |
0.536
|
|
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.531
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.531
|
|
|
|
reactive nitrogen species metabolic process
|
GO:2001057 |
3 |
0.528
|
|
|
|
gland morphogenesis
|
GO:0022612 |
8 |
0.528
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.525
|
|
|
|
mammary gland development
|
GO:0030879 |
17 |
0.523
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.518
|
|
|
|
regulation of peptide secretion
|
GO:0002791 |
42 |
0.511
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.510
|
|
|
|
urogenital system development
|
GO:0001655 |
65 |
0.508
|
Human |
|
|
peptide hormone secretion
|
GO:0030072 |
50 |
0.508
|
|
|
|
glucose transport
|
GO:0015758 |
30 |
0.508
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.507
|
|
|
|
digestive tract morphogenesis
|
GO:0048546 |
56 |
0.505
|
Zebrafish |
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.501
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.496
|
|
|
|
renal system development
|
GO:0072001 |
63 |
0.494
|
Human |
|
|
positive regulation of hormone secretion
|
GO:0046887 |
25 |
0.494
|
|
|
|
sex determination
|
GO:0007530 |
3 |
0.494
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.492
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.491
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.490
|
|
|
|
regulation of peptide hormone secretion
|
GO:0090276 |
41 |
0.488
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.482
|
|
|
|
regulation of cell motility
|
GO:2000145 |
299 |
0.482
|
Mouse |
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.478
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.477
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.477
|
|
|
|
regulation of mononuclear cell proliferation
|
GO:0032944 |
65 |
0.472
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.471
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.470
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.470
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.465
|
|
|
|
cell migration involved in gastrulation
|
GO:0042074 |
1 |
0.464
|
Zebrafish |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.463
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.448
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.447
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.447
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.446
|
|
|
|
regulation of hormone secretion
|
GO:0046883 |
57 |
0.444
|
|
|
|
cellular response to interleukin 15
|
GO:0071350 |
6 |
0.444
|
|
|
|
positive regulation of insulin secretion
|
GO:0032024 |
10 |
0.444
|
|
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.442
|
|
|
|
response to interleukin 13
|
GO:0035962 |
4 |
0.442
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.438
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.438
|
|
|
|
amide transport
|
GO:0042886 |
76 |
0.435
|
|
|
|
sensory organ development
|
GO:0007423 |
52 |
0.435
|
Zebrafish Mouse |
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.434
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.434
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.429
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.427
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.426
|
Mouse |
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.413
|
|
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.411
|
|
|
|
neuron differentiation
|
GO:0030182 |
138 |
0.401
|
Zebrafish Mouse |
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.401
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.394
|
Human Zebrafish |
|
|
activation of janus kinase activity
|
GO:0042976 |
7 |
0.393
|
|
|
|
response to radiation
|
GO:0009314 |
151 |
0.392
|
|
|
|
cellular amide metabolic process
|
GO:0043603 |
69 |
0.390
|
|
|
|
positive regulation of peptide hormone secretion
|
GO:0090277 |
15 |
0.390
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.386
|
|
|
|
tyrosine phosphorylation of stat5 protein
|
GO:0042506 |
13 |
0.384
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.382
|
|
|
|
pattern specification process
|
GO:0007389 |
43 |
0.376
|
|
|
|
regulation of calcium ion transmembrane transport
|
GO:1903169 |
28 |
0.372
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.372
|
Zebrafish |
|
|
innate immune response
|
GO:0045087 |
178 |
0.366
|
Human |
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.364
|
|
|
|
intracellular receptor signaling pathway
|
GO:0030522 |
104 |
0.364
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.363
|
|
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.361
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.358
|
|
|
|
regulation of glucose transport
|
GO:0010827 |
23 |
0.356
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.355
|
|
|
|
positive regulation of leukocyte proliferation
|
GO:0070665 |
48 |
0.355
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.354
|
|
|
|
negative regulation of erythrocyte differentiation
|
GO:0045647 |
3 |
0.354
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.349
|
|
|
|
negative regulation of response to cytokine stimulus
|
GO:0060761 |
25 |
0.348
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.347
|
|
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.346
|
|
|
|
positive regulation of innate immune response
|
GO:0045089 |
79 |
0.345
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.343
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.342
|
|
|
|
branched chain amino acid metabolic process
|
GO:0009081 |
4 |
0.341
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.336
|
|
|
|
regulation of t cell proliferation
|
GO:0042129 |
42 |
0.335
|
|
|
|
regulation of jak stat cascade
|
GO:0046425 |
44 |
0.332
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.329
|
Zebrafish |
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.326
|
|
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.325
|
|
|
|
type b pancreatic cell apoptotic process
|
GO:0097050 |
5 |
0.325
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.322
|
|
|
|
protein targeting
|
GO:0006605 |
187 |
0.321
|
|
|
|
response to interferon gamma
|
GO:0034341 |
39 |
0.320
|
Human |
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.319
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.317
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.317
|
|
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.314
|
|
|
|
sulfur compound metabolic process
|
GO:0006790 |
101 |
0.305
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.303
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.301
|
|
|
|
negative regulation of peptidyl tyrosine phosphorylation
|
GO:0050732 |
20 |
0.300
|
|
|
|
regulation of antimicrobial humoral response
|
GO:0002759 |
1 |
0.298
|
|
|
|
positive regulation of interferon gamma production
|
GO:0032729 |
26 |
0.293
|
|
|
|
reproductive process
|
GO:0022414 |
106 |
0.291
|
Mouse |
|
|
growth
|
GO:0040007 |
202 |
0.289
|
Zebrafish Mouse |
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.286
|
|
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.281
|
|
|
|
defense response to virus
|
GO:0051607 |
71 |
0.279
|
|
|
|
positive regulation of mononuclear cell proliferation
|
GO:0032946 |
47 |
0.276
|
|
|
|
regulation of astrocyte differentiation
|
GO:0048710 |
3 |
0.275
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.271
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.270
|
|
|
|
negative regulation of myeloid cell differentiation
|
GO:0045638 |
42 |
0.270
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.270
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.266
|
|
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.266
|
|
|
|
glucose import
|
GO:0046323 |
24 |
0.265
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.263
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.262
|
|
|
|
positive regulation of glial cell proliferation
|
GO:0060252 |
2 |
0.261
|
Zebrafish |
|
|
behavior
|
GO:0007610 |
112 |
0.261
|
Mouse |
|
|
chromatin organization
|
GO:0006325 |
351 |
0.259
|
|
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.258
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.258
|
|
|
|
system process
|
GO:0003008 |
349 |
0.257
|
|
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.257
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.255
|
Human |
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.254
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.252
|
|
|
|
endothelial cell proliferation
|
GO:0001935 |
65 |
0.251
|
Human |
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.251
|
|
|
|
positive regulation of t cell activation
|
GO:0050870 |
54 |
0.250
|
|
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.249
|
|
|
|
embryo development
|
GO:0009790 |
123 |
0.249
|
Zebrafish |
|
|
lymphocyte differentiation
|
GO:0030098 |
35 |
0.248
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.247
|
|
|
|
regulation of tyrosine phosphorylation of stat1 protein
|
GO:0042510 |
11 |
0.247
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.245
|
|
|
|
protein autoprocessing
|
GO:0016540 |
4 |
0.245
|
|
|
|
regulation of nitric oxide biosynthetic process
|
GO:0045428 |
17 |
0.244
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.243
|
|
|
|
positive regulation of peptide secretion
|
GO:0002793 |
15 |
0.243
|
|
|
|
positive regulation of jak stat cascade
|
GO:0046427 |
35 |
0.242
|
|
|
|
positive regulation of t cell proliferation
|
GO:0042102 |
33 |
0.241
|
|
|
|
polysaccharide metabolic process
|
GO:0005976 |
33 |
0.240
|
|
|
|
signal release
|
GO:0023061 |
70 |
0.238
|
|
|
|
cellular glucan metabolic process
|
GO:0006073 |
22 |
0.235
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.235
|
Zebrafish |
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.232
|
|
|
|
interferon gamma production
|
GO:0032609 |
39 |
0.230
|
|
|
|
hormone transport
|
GO:0009914 |
68 |
0.229
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.228
|
|
|
|
response to interleukin 15
|
GO:0070672 |
6 |
0.226
|
|
|
|
actin mediated cell contraction
|
GO:0070252 |
12 |
0.226
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.224
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.221
|
Zebrafish |
|
|
acylglycerol metabolic process
|
GO:0006639 |
27 |
0.220
|
|
|
|
positive regulation of reactive oxygen species metabolic process
|
GO:2000379 |
24 |
0.218
|
|
|
|
positive regulation of reactive oxygen species biosynthetic process
|
GO:1903428 |
2 |
0.214
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.213
|
|
|
|
multicellular organismal reproductive process
|
GO:0048609 |
40 |
0.206
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.203
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.200
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.200
|
|
|
|
type i interferon signaling pathway
|
GO:0060337 |
11 |
0.198
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.197
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.197
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.196
|
|
|
|
negative regulation of i kappab kinase nf kappab signaling
|
GO:0043124 |
32 |
0.195
|
Human |
|
|
regulation of lipid metabolic process
|
GO:0019216 |
96 |
0.193
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.189
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.187
|
|
|
|
positive regulation of ossification
|
GO:0045778 |
32 |
0.186
|
|
|
|
creatinine metabolic process
|
GO:0046449 |
1 |
0.185
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.184
|
|
|
|
defense response to bacterium
|
GO:0042742 |
63 |
0.184
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.183
|
|
|
|
regulation of glial cell differentiation
|
GO:0045685 |
3 |
0.182
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
40 |
0.181
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.181
|
|
|
|
regulation of polysaccharide biosynthetic process
|
GO:0032885 |
20 |
0.180
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.179
|
|
|
|
t cell differentiation
|
GO:0030217 |
29 |
0.177
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.175
|
Zebrafish |
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.174
|
|
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.174
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.173
|
|
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.172
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.172
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.172
|
|
|
|
somatic stem cell maintenance
|
GO:0035019 |
4 |
0.170
|
|
|
|
regulation of cell cell adhesion
|
GO:0022407 |
57 |
0.170
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.170
|
|
|
|
regulation of glial cell proliferation
|
GO:0060251 |
4 |
0.170
|
Zebrafish |
|
|
negative regulation of vasculature development
|
GO:1901343 |
43 |
0.167
|
Human |
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.165
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.164
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.163
|
Mouse |
|
|
positive regulation of secretion by cell
|
GO:1903532 |
108 |
0.162
|
|
|
|
cellular response to interleukin 4
|
GO:0071353 |
7 |
0.161
|
Human |
|
|
positive regulation of glucose transport
|
GO:0010828 |
17 |
0.161
|
|
|
|
histone phosphorylation
|
GO:0016572 |
16 |
0.161
|
|
|
|
regulation of neurogenesis
|
GO:0050767 |
82 |
0.160
|
Zebrafish Mouse |
|
|
endocytosis
|
GO:0006897 |
159 |
0.157
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.156
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.156
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.156
|
|
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.156
|
|
|
|
midgut development
|
GO:0007494 |
1 |
0.154
|
|
|
|
positive regulation of necrotic cell death
|
GO:0010940 |
4 |
0.150
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.149
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.147
|
|
|
|
response to fibroblast growth factor
|
GO:0071774 |
39 |
0.146
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.145
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.145
|
Human |
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.145
|
|
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.145
|
Zebrafish |
|
|
stem cell division
|
GO:0017145 |
2 |
0.145
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
|
GO:0042771 |
23 |
0.142
|
|
|
|
developmental process involved in reproduction
|
GO:0003006 |
66 |
0.141
|
|
|
|
t cell differentiation in thymus
|
GO:0033077 |
4 |
0.141
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.141
|
|
|
|
mononuclear cell proliferation
|
GO:0032943 |
71 |
0.139
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.139
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.138
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.137
|
|
|
|
positive regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042523 |
11 |
0.133
|
|
|
|
regulation of endothelial cell proliferation
|
GO:0001936 |
56 |
0.132
|
Human |
|
|
vasculature development
|
GO:0001944 |
181 |
0.129
|
Human |
|
|
cytokine biosynthetic process
|
GO:0042089 |
37 |
0.128
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.127
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.126
|
|
|
|
regulation of tyrosine phosphorylation of stat5 protein
|
GO:0042522 |
12 |
0.126
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.125
|
|
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.125
|
|
|
|
rhythmic process
|
GO:0048511 |
31 |
0.125
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.124
|
|
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.123
|
|
|
|
regulation of epithelial cell proliferation
|
GO:0050678 |
113 |
0.122
|
Human |
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
27 |
0.122
|
Human |
|
|
cell communication by electrical coupling involved in cardiac conduction
|
GO:0086064 |
3 |
0.121
|
|
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.120
|
Zebrafish Mouse |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.118
|
|
|
|
tube morphogenesis
|
GO:0035239 |
95 |
0.117
|
Zebrafish |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.116
|
|
|
|
negative regulation of endothelial cell proliferation
|
GO:0001937 |
20 |
0.115
|
Human |
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.115
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.115
|
|
|
|
axon development
|
GO:0061564 |
34 |
0.114
|
Zebrafish |
|
|
tricarboxylic acid metabolic process
|
GO:0072350 |
4 |
0.113
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.113
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.111
|
|
|
|
response to ethanol
|
GO:0045471 |
11 |
0.111
|
Rat |
|
|
t helper cell differentiation
|
GO:0042093 |
4 |
0.111
|
|
|
|
regulation of interleukin 10 biosynthetic process
|
GO:0045074 |
2 |
0.110
|
|
|
|
response to virus
|
GO:0009615 |
126 |
0.109
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.108
|
|
|
|
regulation of cardiac muscle contraction
|
GO:0055117 |
33 |
0.107
|
|
|
|
central nervous system development
|
GO:0007417 |
123 |
0.106
|
Mouse |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.106
|
|
|
|
syncytium formation by plasma membrane fusion
|
GO:0000768 |
2 |
0.106
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.104
|
|
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.104
|
|
|
|
positive regulation of glial cell differentiation
|
GO:0045687 |
2 |
0.102
|
|
|
|
positive regulation of osteoblast differentiation
|
GO:0045669 |
23 |
0.102
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.101
|
|
|
|
tumor necrosis factor production
|
GO:0032640 |
43 |
0.100
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.100
|
|
|
|
erythrocyte differentiation
|
GO:0030218 |
28 |
0.099
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.099
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.098
|
Human |
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.098
|
|
|
|
positive regulation of lymphocyte proliferation
|
GO:0050671 |
46 |
0.097
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.096
|
Zebrafish |
|
|
regulation of calcium ion transmembrane transporter activity
|
GO:1901019 |
28 |
0.096
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.096
|
Human Zebrafish |
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.095
|
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
32 |
0.095
|
|
|
|
cardiac muscle cell contraction
|
GO:0086003 |
4 |
0.095
|
|
|
|
neural tube patterning
|
GO:0021532 |
2 |
0.095
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.095
|
Zebrafish Mouse |
|
|
taurine metabolic process
|
GO:0019530 |
1 |
0.094
|
|
|
|
regulation of interferon gamma production
|
GO:0032649 |
36 |
0.094
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.093
|
|
|
|
hematopoietic stem cell differentiation
|
GO:0060218 |
4 |
0.093
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.092
|
|
|
|
neutral lipid metabolic process
|
GO:0006638 |
27 |
0.091
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.091
|
Zebrafish |
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.091
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.089
|
|
|
|
regulation of defense response to virus by host
|
GO:0050691 |
22 |
0.088
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.088
|
|
|
|
regulation of peptide transport
|
GO:0090087 |
62 |
0.088
|
|
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.087
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.087
|
Zebrafish |
|
|
tissue regeneration
|
GO:0042246 |
3 |
0.087
|
Zebrafish |
|
|
microtubule based process
|
GO:0007017 |
210 |
0.086
|
|
