Homo sapiens

109 known processes

STK3

serine/threonine kinase 3

(Aliases: FLJ90748,KRS1,MST2)

STK3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
hippo signaling GO:0035329 20 1.000
negative regulation of cell cycle arrest GO:0071157 12 0.999
regulation of cell cycle arrest GO:0071156 36 0.998
keratinocyte differentiation GO:0030216 36 0.996
epidermal cell differentiation GO:0009913 45 0.985
neural tube formation GO:0001841 3 0.966
Mouse
small gtpase mediated signal transduction GO:0007264 78 0.962
ras protein signal transduction GO:0007265 73 0.953
protein stabilization GO:0050821 64 0.946
circulatory system development GO:0072359 262 0.933
Mouse
negative regulation of wnt signaling pathway GO:0030178 69 0.912
negative regulation of cell proliferation GO:0008285 228 0.912
Mouse
skin development GO:0043588 76 0.905
epidermis development GO:0008544 59 0.900
regulation of protein stability GO:0031647 87 0.888
cell morphogenesis GO:0000902 296 0.884
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.884
cell cycle arrest GO:0007050 71 0.872
positive regulation of cell differentiation GO:0045597 211 0.861
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 3 0.860
Mouse
patterning of blood vessels GO:0001569 2 0.853
regulation of neuron differentiation GO:0045664 70 0.850
positive regulation of cell death GO:0010942 263 0.839
Human Mouse
posttranscriptional regulation of gene expression GO:0010608 213 0.826
tube development GO:0035295 125 0.814
Mouse
positive regulation of programmed cell death GO:0043068 249 0.809
Human Mouse
cellular response to dna damage stimulus GO:0006974 379 0.763
epithelial cell differentiation GO:0030855 141 0.760
embryonic epithelial tube formation GO:0001838 4 0.741
Mouse
negative regulation of glial cell proliferation GO:0060253 2 0.728
canonical wnt signaling pathway GO:0060070 116 0.724
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.720
positive regulation of developmental process GO:0051094 314 0.715
regulation of cell development GO:0060284 161 0.694
positive regulation of protein ubiquitination GO:0031398 53 0.690
regulation of mapk cascade GO:0043408 262 0.659
Mouse
growth GO:0040007 202 0.647
Mouse
determination of adult lifespan GO:0008340 2 0.636
Worm
protein ubiquitination GO:0016567 314 0.619
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.608
ventricular septum morphogenesis GO:0060412 3 0.583
regulation of neurogenesis GO:0050767 82 0.580
protein modification by small protein conjugation GO:0032446 342 0.575
cell type specific apoptotic process GO:0097285 125 0.572
Mouse
multicellular organismal aging GO:0010259 3 0.561
Worm
regulation of cell cycle process GO:0010564 266 0.552
regulation of cell differentiation GO:0045595 393 0.550
positive regulation of fat cell differentiation GO:0045600 12 0.542
neuron differentiation GO:0030182 138 0.519
response to ionizing radiation GO:0010212 65 0.504
neuron projection development GO:0031175 106 0.504
intestinal epithelial cell differentiation GO:0060575 3 0.503
regulation of fat cell differentiation GO:0045598 23 0.503
cellular component morphogenesis GO:0032989 314 0.502
Human
embryonic hemopoiesis GO:0035162 4 0.495
Mouse
cell development GO:0048468 328 0.492
Worm
regulation of cell cycle GO:0051726 393 0.473
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.470
negative regulation of cardiac muscle cell proliferation GO:0060044 2 0.469
positive regulation of protein phosphorylation GO:0001934 313 0.468
regulation of cell morphogenesis GO:0022604 153 0.459
regulation of cardiac muscle cell proliferation GO:0060043 4 0.458
positive regulation of phosphorylation GO:0042327 394 0.456
Mouse
regulation of dendrite morphogenesis GO:0048814 11 0.448
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.447
positive regulation of apoptotic process GO:0043065 246 0.445
Human Mouse
digestive system development GO:0055123 75 0.445
negative regulation of cell cycle process GO:0010948 121 0.434
epithelium development GO:0060429 227 0.424
Mouse
developmental programmed cell death GO:0010623 3 0.398
heart development GO:0007507 95 0.393
Mouse
hair cycle GO:0042633 28 0.393
organ morphogenesis GO:0009887 147 0.384
regulation of dendrite development GO:0050773 18 0.376
regulation of stem cell maintenance GO:2000036 4 0.375
endocardium development GO:0003157 2 0.371
Mouse
regulation of growth GO:0040008 165 0.369
Mouse
positive regulation of apoptotic signaling pathway GO:2001235 70 0.369
Mouse
negative regulation of heart growth GO:0061117 2 0.365
peptidyl serine modification GO:0018209 106 0.361
Human
embryonic placenta development GO:0001892 1 0.358
Mouse
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.350
Mouse
negative regulation of developmental process GO:0051093 247 0.348
Mouse
neuron development GO:0048666 113 0.345
lung epithelial cell differentiation GO:0060487 1 0.339
cardiovascular system development GO:0072358 262 0.331
Mouse
wnt signaling pathway GO:0016055 156 0.322
regulation of heart growth GO:0060420 4 0.322
actin filament based process GO:0030029 224 0.307
negative regulation of cardiac muscle tissue development GO:0055026 7 0.302
positive regulation of jnk cascade GO:0046330 52 0.284
Mouse
organ growth GO:0035265 12 0.277
Mouse
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.268
Mouse
negative regulation of striated muscle tissue development GO:0045843 11 0.262
regulation of apoptotic signaling pathway GO:2001233 175 0.262
Mouse
fat cell differentiation GO:0045444 32 0.257
negative regulation of cardiac muscle tissue growth GO:0055022 2 0.257
positive regulation of protein kinase activity GO:0045860 190 0.246
morphogenesis of an epithelium GO:0002009 60 0.226
Mouse
protein autophosphorylation GO:0046777 123 0.224
Human
mapk cascade GO:0000165 288 0.219
Mouse
regulation of epithelial cell proliferation GO:0050678 113 0.217
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 24 0.216
Mouse
intracellular protein transport GO:0006886 270 0.216
central nervous system development GO:0007417 123 0.210
Mouse
negative regulation of developmental growth GO:0048640 10 0.207
Mouse
negative regulation of epithelial cell proliferation GO:0050680 48 0.207
hemopoiesis GO:0030097 180 0.207
Mouse
negative regulation of growth GO:0045926 97 0.205
Mouse
morphogenesis of embryonic epithelium GO:0016331 4 0.202
Mouse
negative regulation of organ growth GO:0046621 5 0.196
Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.191
peptidyl serine phosphorylation GO:0018105 101 0.188
Human
regulation of cellular amino acid metabolic process GO:0006521 6 0.187
negative regulation of cell death GO:0060548 345 0.184
regulation of protein kinase activity GO:0045859 289 0.182
muscle fiber development GO:0048747 16 0.164
Worm
anatomical structure formation involved in morphogenesis GO:0048646 284 0.162
Mouse
post embryonic development GO:0009791 2 0.160
extrinsic apoptotic signaling pathway GO:0097191 119 0.156
Mouse
heart morphogenesis GO:0003007 48 0.155
response to radiation GO:0009314 151 0.155
regulation of multicellular organism growth GO:0040014 8 0.151
positive regulation of protein binding GO:0032092 24 0.148
positive regulation of mapk cascade GO:0043410 190 0.143
Mouse
immune system development GO:0002520 195 0.132
Mouse
lung cell differentiation GO:0060479 1 0.127
cardiac muscle cell proliferation GO:0060038 6 0.125
negative regulation of cell cycle GO:0045786 193 0.125
regulation of nervous system development GO:0051960 88 0.123
lung epithelium development GO:0060428 7 0.120
regulation of stress activated mapk cascade GO:0032872 84 0.119
Mouse
neurogenesis GO:0022008 169 0.118
negative regulation of muscle organ development GO:0048635 12 0.116
cell morphogenesis involved in differentiation GO:0000904 144 0.114
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.111
positive regulation of cellular component organization GO:0051130 376 0.108
regulation of transferase activity GO:0051338 355 0.108
cell projection morphogenesis GO:0048858 129 0.104
regulation of neuron projection development GO:0010975 57 0.103
embryonic organ development GO:0048568 36 0.103
Mouse
regulation of protein serine threonine kinase activity GO:0071900 179 0.102
neuron projection morphogenesis GO:0048812 50 0.101
response to abiotic stimulus GO:0009628 336 0.100
regulation of muscle tissue development GO:1901861 26 0.098
locomotory behavior GO:0007626 1 0.096
neural tube development GO:0021915 9 0.096
Mouse
digestive tract development GO:0048565 75 0.095
cell projection organization GO:0030030 252 0.095
striated muscle cell development GO:0055002 27 0.094
Worm
negative regulation of apoptotic process GO:0043066 316 0.092
cardiac chamber development GO:0003205 30 0.092
striated muscle cell differentiation GO:0051146 43 0.090
Worm
generation of neurons GO:0048699 152 0.086
amine metabolic process GO:0009308 44 0.086
regulation of cell projection organization GO:0031344 107 0.085
regulation of jnk cascade GO:0046328 73 0.085
Mouse
dendrite development GO:0016358 24 0.084
respiratory tube development GO:0030323 20 0.083
protein localization to organelle GO:0033365 280 0.081
regulation of cellular component biogenesis GO:0044087 281 0.081
columnar cuboidal epithelial cell differentiation GO:0002065 14 0.081
signal transduction by phosphorylation GO:0023014 297 0.078
Mouse
membrane organization GO:0061024 292 0.078
developmental growth GO:0048589 48 0.076
Mouse
head development GO:0060322 108 0.076
positive regulation of cellular amine metabolic process GO:0033240 7 0.075
regulation of striated muscle tissue development GO:0016202 26 0.075
lung development GO:0030324 20 0.075
response to hormone GO:0009725 175 0.075
regulation of cardiac muscle tissue growth GO:0055021 4 0.073
regulation of protein binding GO:0043393 66 0.072
vasculature development GO:0001944 181 0.071
regulation of muscle organ development GO:0048634 27 0.068
stem cell development GO:0048864 69 0.068
jnk cascade GO:0007254 80 0.068
Mouse
heart contraction GO:0060047 62 0.068
morphogenesis of a branching epithelium GO:0061138 20 0.066
blood vessel morphogenesis GO:0048514 162 0.064
cellular amino acid metabolic process GO:0006520 116 0.063
regulation of cell motility GO:2000145 299 0.062
response to cytokine GO:0034097 232 0.062
rho protein signal transduction GO:0007266 26 0.062
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.060
regulation of stem cell differentiation GO:2000736 56 0.059
cell part morphogenesis GO:0032990 137 0.059
regulation of cellular amine metabolic process GO:0033238 11 0.059
cardiac muscle tissue development GO:0048738 39 0.058
muscle cell development GO:0055001 29 0.058
Worm
positive regulation of cellular component biogenesis GO:0044089 158 0.057
blood vessel development GO:0001568 172 0.057
tissue morphogenesis GO:0048729 96 0.056
Mouse
angiogenesis GO:0001525 147 0.056
cellular ketone metabolic process GO:0042180 80 0.056
neuromuscular junction development GO:0007528 3 0.055
rap protein signal transduction GO:0032486 7 0.054
negative regulation of protein phosphorylation GO:0001933 140 0.053
eye morphogenesis GO:0048592 16 0.052
cellular component disassembly GO:0022411 92 0.052
aging GO:0007568 66 0.051
Worm
positive regulation of stress activated mapk cascade GO:0032874 60 0.051
Mouse
muscle cell differentiation GO:0042692 63 0.051
Worm
epithelial cell proliferation GO:0050673 128 0.049
sensory organ development GO:0007423 52 0.049
Zebrafish
regulation of anatomical structure size GO:0090066 101 0.049
muscle structure development GO:0061061 98 0.048
Worm
muscle organ development GO:0007517 56 0.048
cardiac ventricle development GO:0003231 23 0.047
dendrite morphogenesis GO:0048813 14 0.046
heart growth GO:0060419 6 0.046
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 36 0.045
positive regulation of axon extension GO:0045773 4 0.045
protein import into nucleus GO:0006606 104 0.045
establishment of protein localization to organelle GO:0072594 172 0.044
cellular amine metabolic process GO:0044106 41 0.043
female gamete generation GO:0007292 2 0.042
regulation of protein localization GO:0032880 296 0.042
positive regulation of kinase activity GO:0033674 204 0.042
morphogenesis of a branching structure GO:0001763 21 0.042
striated muscle cell proliferation GO:0014855 7 0.041
regulation of kinase activity GO:0043549 314 0.041
negative regulation of phosphate metabolic process GO:0045936 267 0.040
regulation of ras protein signal transduction GO:0046578 155 0.039
negative regulation of protein complex disassembly GO:0043242 20 0.039
cytoskeleton dependent intracellular transport GO:0030705 21 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.038
cytokinesis GO:0000910 96 0.038
regulation of cell migration GO:0030334 289 0.037
microtubule based process GO:0007017 210 0.036
regulation of developmental growth GO:0048638 30 0.036
Mouse
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.036
nervous system development GO:0007399 293 0.036
Mouse
actin cytoskeleton organization GO:0030036 207 0.036
muscle cell proliferation GO:0033002 35 0.035
regulation of cellular response to stress GO:0080135 244 0.035
Mouse
pattern specification process GO:0007389 43 0.035
erk1 and erk2 cascade GO:0070371 104 0.034
cell activation GO:0001775 213 0.034
negative regulation of muscle tissue development GO:1901862 11 0.034
cell cycle phase transition GO:0044770 173 0.033
sister chromatid segregation GO:0000819 54 0.033
stem cell differentiation GO:0048863 93 0.033
trachea development GO:0060438 1 0.033
protein targeting GO:0006605 187 0.033
compound eye development GO:0048749 1 0.032
establishment or maintenance of actin cytoskeleton polarity GO:0030950 1 0.032
branching morphogenesis of an epithelial tube GO:0048754 19 0.032
negative regulation of cell differentiation GO:0045596 171 0.030
regulation of protein localization to nucleus GO:1900180 85 0.030
intrinsic apoptotic signaling pathway GO:0097193 127 0.029
protein localization to nucleus GO:0034504 136 0.029
negative regulation of protein kinase activity GO:0006469 98 0.029
regulation of locomotion GO:0040012 329 0.028
endomembrane system organization GO:0010256 196 0.028
cell fate determination GO:0001709 3 0.028
response to gamma radiation GO:0010332 14 0.028
immune response GO:0006955 307 0.027
hormone mediated signaling pathway GO:0009755 22 0.027
negative regulation of transport GO:0051051 176 0.027
negative regulation of cellular protein metabolic process GO:0032269 353 0.027
gtp catabolic process GO:0006184 237 0.027
protein localization to membrane GO:0072657 160 0.027
single organism membrane organization GO:0044802 268 0.026
negative regulation of rho gtpase activity GO:0034259 4 0.026
regulation of heart contraction GO:0008016 50 0.026
axon cargo transport GO:0008088 2 0.026
sensory organ morphogenesis GO:0090596 21 0.026
blood circulation GO:0008015 113 0.025
actin filament polymerization GO:0030041 45 0.025
microtubule cytoskeleton organization GO:0000226 176 0.025
positive regulation of transferase activity GO:0051347 227 0.025
single organism reproductive process GO:0044702 98 0.025
Mouse
leukocyte migration GO:0050900 107 0.024
establishment of protein localization to membrane GO:0090150 121 0.024
reproductive structure development GO:0048608 55 0.024
Mouse
embryo development GO:0009790 123 0.024
Mouse
positive regulation of cell development GO:0010720 92 0.023
maintenance of location GO:0051235 112 0.023
muscle tissue development GO:0060537 62 0.023
g1 s transition of mitotic cell cycle GO:0000082 78 0.023
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 23 0.023
regulation of cellular component size GO:0032535 82 0.023
coenzyme metabolic process GO:0006732 65 0.022
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.022
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.022
oogenesis GO:0048477 2 0.021
embryonic morphogenesis GO:0048598 85 0.021
Mouse
developmental process involved in reproduction GO:0003006 66 0.020
Mouse
molting cycle GO:0042303 28 0.020
cardiac septum development GO:0003279 13 0.020
microtubule organizing center organization GO:0031023 62 0.020
oxidation reduction process GO:0055114 396 0.019
tube morphogenesis GO:0035239 95 0.019
Mouse
nucleus organization GO:0006997 28 0.019
striated muscle tissue development GO:0014706 59 0.019
response to biotic stimulus GO:0009607 276 0.018
negative regulation of cell development GO:0010721 48 0.018
negative regulation of protein modification process GO:0031400 200 0.018
oocyte development GO:0048599 1 0.018
response to lipopolysaccharide GO:0032496 70 0.018
taxis GO:0042330 157 0.018
brain development GO:0007420 97 0.018
positive regulation of small gtpase mediated signal transduction GO:0051057 12 0.017
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.017
positive regulation of transport GO:0051050 336 0.017
regulation of actin filament based process GO:0032970 141 0.017
positive regulation of rap gtpase activity GO:0032854 8 0.017
cellular cation homeostasis GO:0030003 163 0.016
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.016
regulation of myeloid leukocyte mediated immunity GO:0002886 4 0.016
maintenance of cell polarity GO:0030011 2 0.016
negative regulation of kinase activity GO:0033673 106 0.016
regulation of system process GO:0044057 101 0.016
epithelial tube formation GO:0072175 5 0.016
Mouse
reproduction GO:0000003 63 0.016
segmentation GO:0035282 4 0.016
positive regulation of cell projection organization GO:0031346 64 0.016
nucleotide biosynthetic process GO:0009165 109 0.016
membrane raft localization GO:0051665 1 0.016
execution phase of apoptosis GO:0097194 32 0.015
lymphocyte activation GO:0046649 133 0.015
negative regulation of gliogenesis GO:0014014 3 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
regulation of protein ubiquitination GO:0031396 95 0.015
guanosine containing compound catabolic process GO:1901069 239 0.015
protein maturation GO:0051604 233 0.015
positive regulation of neuron projection development GO:0010976 34 0.015
regulation of cell growth GO:0001558 135 0.015
regulation of organ growth GO:0046620 7 0.015
Mouse
epithelial tube morphogenesis GO:0060562 38 0.015
Mouse
mitotic cell cycle process GO:1903047 286 0.015
single organism cellular localization GO:1902580 332 0.015
establishment or maintenance of cell polarity GO:0007163 31 0.014
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.014
regulation of erk1 and erk2 cascade GO:0070372 99 0.014
rhythmic behavior GO:0007622 2 0.014
maintenance of protein location GO:0045185 57 0.014
cell adhesion GO:0007155 325 0.014
negative regulation of organelle organization GO:0010639 126 0.014
circadian behavior GO:0048512 2 0.014
cellular response to lipid GO:0071396 127 0.014
negative regulation of catalytic activity GO:0043086 335 0.013
positive regulation of rho gtpase activity GO:0032321 56 0.013
cellular macromolecule catabolic process GO:0044265 380 0.013
regulation of rap protein signal transduction GO:0032487 9 0.013
regulation of small gtpase mediated signal transduction GO:0051056 156 0.013
signal transduction by p53 class mediator GO:0072331 72 0.013
negative regulation of cell migration GO:0030336 102 0.013
positive regulation of lyase activity GO:0051349 16 0.013
carbon catabolite activation of transcription GO:0045991 3 0.013
cardiac muscle tissue growth GO:0055017 6 0.013
cell growth GO:0016049 160 0.013
hair follicle development GO:0001942 11 0.013
negative regulation of ras gtpase activity GO:0034261 6 0.013
stress activated protein kinase signaling cascade GO:0031098 94 0.013
Mouse
negative regulation of phosphorus metabolic process GO:0010563 267 0.013
adult locomotory behavior GO:0008344 1 0.012
response to axon injury GO:0048678 1 0.012
reproductive process GO:0022414 106 0.012
Mouse
regulation of peptidyl serine phosphorylation GO:0033135 50 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
regulation of cell projection assembly GO:0060491 47 0.012
mitotic cell cycle GO:0000278 326 0.012
ribose phosphate biosynthetic process GO:0046390 82 0.012
regulation of actin polymerization or depolymerization GO:0008064 56 0.012
regulation of cellular component movement GO:0051270 334 0.012
metal ion transport GO:0030001 272 0.012
microtubule based movement GO:0007018 32 0.012
purine ribonucleotide catabolic process GO:0009154 404 0.012
protein localization to endoplasmic reticulum GO:0070972 19 0.011
interspecies interaction between organisms GO:0044419 156 0.011
cell division GO:0051301 168 0.011
neurotransmitter secretion GO:0007269 4 0.011
apoptotic mitochondrial changes GO:0008637 57 0.011
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 45 0.011
regulation of protein transport GO:0051223 213 0.011
hair cycle process GO:0022405 12 0.011
regulation of actin cytoskeleton organization GO:0032956 116 0.011
cell junction assembly GO:0034329 67 0.011
chordate embryonic development GO:0043009 34 0.011
Mouse
protein oligomerization GO:0051259 173 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.011
cytoplasmic sequestering of protein GO:0051220 12 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.011
cellular protein complex assembly GO:0043623 188 0.011
organelle assembly GO:0070925 176 0.011
regulation of cytoplasmic transport GO:1903649 149 0.011
cellular divalent inorganic cation homeostasis GO:0072503 128 0.010
stress activated mapk cascade GO:0051403 93 0.010
Mouse
establishment or maintenance of bipolar cell polarity GO:0061245 2 0.010
regulation of secretion GO:0051046 194 0.010
positive regulation of immune system process GO:0002684 283 0.010
response to oxidative stress GO:0006979 121 0.010
positive regulation of neural precursor cell proliferation GO:2000179 2 0.010
regulation of wnt signaling pathway GO:0030111 123 0.010
oocyte differentiation GO:0009994 2 0.010
response to organic cyclic compound GO:0014070 204 0.010
positive regulation of cell proliferation GO:0008284 301 0.010

STK3 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.042
disease of cellular proliferation DOID:14566 174 0.042
organ system cancer DOID:0050686 164 0.042
sensory system disease DOID:0050155 203 0.012
eye and adnexa disease DOID:1492 150 0.012
nervous system disease DOID:863 431 0.012
retinal disease DOID:5679 118 0.011
retinal degeneration DOID:8466 89 0.011
eye disease DOID:5614 149 0.011