Homo sapiens

126 known processes

STUB1

STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase

(Aliases: HSPABP2,CHIP,UBOX1,SDCCAG7,NY-CO-7)

STUB1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein ubiquitination GO:0016567 314 1.000
protein modification by small protein conjugation GO:0032446 342 0.999
modification dependent protein catabolic process GO:0019941 209 0.994
protein refolding GO:0042026 14 0.991
chaperone cofactor dependent protein refolding GO:0070389 4 0.972
modification dependent macromolecule catabolic process GO:0043632 212 0.948
positive regulation of programmed cell death GO:0043068 249 0.919
cellular protein catabolic process GO:0044257 261 0.898
protein polyubiquitination GO:0000209 110 0.889
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.880
negative regulation of apoptotic process GO:0043066 316 0.864
protein catabolic process GO:0030163 325 0.846
cellular macromolecule catabolic process GO:0044265 380 0.839
positive regulation of apoptotic process GO:0043065 246 0.827
positive regulation of cell death GO:0010942 263 0.805
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.789
positive regulation of proteolysis GO:0045862 142 0.773
negative regulation of cell death GO:0060548 345 0.745
regulation of jnk cascade GO:0046328 73 0.682
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.669
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.531
response to abiotic stimulus GO:0009628 336 0.507
regulation of protein kinase activity GO:0045859 289 0.483
mapk cascade GO:0000165 288 0.478
regulation of cellular response to stress GO:0080135 244 0.470
ubiquitin dependent protein catabolic process GO:0006511 206 0.470
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.461
jnk cascade GO:0007254 80 0.425
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.392
protein folding GO:0006457 38 0.389
negative regulation of protein modification process GO:0031400 200 0.376
positive regulation of cell cycle GO:0045787 140 0.374
regulation of cell cycle GO:0051726 393 0.370
regulation of proteolysis GO:0030162 293 0.346
nervous system development GO:0007399 293 0.340
negative regulation of cellular protein metabolic process GO:0032269 353 0.335
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.327
cellular ketone metabolic process GO:0042180 80 0.322
response to topologically incorrect protein GO:0035966 29 0.314
positive regulation of cellular catabolic process GO:0031331 284 0.305
regulation of kinase activity GO:0043549 314 0.295
negative regulation of protein phosphorylation GO:0001933 140 0.294
regulation of defense response GO:0031347 154 0.290
de novo protein folding GO:0006458 2 0.290
female gamete generation GO:0007292 2 0.289
negative regulation of cell proliferation GO:0008285 228 0.284
cellular response to topologically incorrect protein GO:0035967 19 0.281
cellular response to dna damage stimulus GO:0006974 379 0.276
apoptotic signaling pathway GO:0097190 268 0.264
purine nucleoside triphosphate metabolic process GO:0009144 412 0.254
regulation of proteasomal protein catabolic process GO:0061136 87 0.247
nucleoside monophosphate metabolic process GO:0009123 191 0.244
growth GO:0040007 202 0.244
positive regulation of cellular amine metabolic process GO:0033240 7 0.238
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.236
chromatin modification GO:0016568 298 0.232
multi organism cellular process GO:0044764 156 0.232
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.229
cell type specific apoptotic process GO:0097285 125 0.218
negative regulation of cell cycle GO:0045786 193 0.213
protein k48 linked ubiquitination GO:0070936 38 0.205
negative regulation of phosphorylation GO:0042326 174 0.204
protein targeting to mitochondrion GO:0006626 19 0.201
defense response GO:0006952 315 0.195
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.188
regulation of protein ubiquitination GO:0031396 95 0.187
i kappab kinase nf kappab signaling GO:0007249 166 0.184
regulation of mapk cascade GO:0043408 262 0.184
generation of neurons GO:0048699 152 0.183
purine nucleoside monophosphate metabolic process GO:0009126 186 0.172
negative regulation of programmed cell death GO:0043069 321 0.170
regulation of endopeptidase activity GO:0052548 170 0.159
regulation of cell differentiation GO:0045595 393 0.159
purine nucleoside catabolic process GO:0006152 398 0.156
purine ribonucleotide catabolic process GO:0009154 404 0.154
regulation of peptidase activity GO:0052547 180 0.153
stress activated protein kinase signaling cascade GO:0031098 94 0.152
regulation of immune response GO:0050776 201 0.150
regulation of nucleotide catabolic process GO:0030811 205 0.148
intrinsic apoptotic signaling pathway GO:0097193 127 0.145
response to nitrogen compound GO:1901698 184 0.144
oogenesis GO:0048477 2 0.143
srp dependent cotranslational protein targeting to membrane GO:0006614 2 0.142
negative regulation of apoptotic signaling pathway GO:2001234 97 0.138
cellular component morphogenesis GO:0032989 314 0.138
Worm
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.138
negative regulation of protein metabolic process GO:0051248 391 0.137
protein oligomerization GO:0051259 173 0.137
cellular protein complex assembly GO:0043623 188 0.136
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.130
immune response GO:0006955 307 0.122
response to lipid GO:0033993 206 0.120
regulation of mitotic cell cycle GO:0007346 189 0.120
regulation of cellular protein catabolic process GO:1903362 96 0.119
positive regulation of catabolic process GO:0009896 310 0.119
negative regulation of phosphate metabolic process GO:0045936 267 0.115
peptidyl serine modification GO:0018209 106 0.115
dna damage checkpoint GO:0000077 68 0.109
cell projection organization GO:0030030 252 0.109
regulation of cellular amine metabolic process GO:0033238 11 0.107
proteasomal protein catabolic process GO:0010498 176 0.105
regulation of cell growth GO:0001558 135 0.104
regulation of cellular ketone metabolic process GO:0010565 50 0.104
positive regulation of neuron apoptotic process GO:0043525 8 0.103
de novo posttranslational protein folding GO:0051084 2 0.100
cell development GO:0048468 328 0.100
Worm
purine ribonucleoside catabolic process GO:0046130 398 0.099
establishment of protein localization to membrane GO:0090150 121 0.095
protein localization to organelle GO:0033365 280 0.093
positive regulation of protein kinase activity GO:0045860 190 0.091
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.089
regulation of stress activated mapk cascade GO:0032872 84 0.089
positive regulation of phosphorylation GO:0042327 394 0.089
neuron apoptotic process GO:0051402 39 0.087
regulation of protein localization GO:0032880 296 0.087
positive regulation of binding GO:0051099 45 0.086
positive regulation of cell differentiation GO:0045597 211 0.085
cell cycle checkpoint GO:0000075 117 0.085
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.083
regulation of protein catabolic process GO:0042176 155 0.083
regulation of cellular amino acid metabolic process GO:0006521 6 0.083
reproductive process GO:0022414 106 0.083
Worm
regulation of apoptotic signaling pathway GO:2001233 175 0.083
multicellular organismal aging GO:0010259 3 0.082
neuron differentiation GO:0030182 138 0.080
determination of adult lifespan GO:0008340 2 0.080
cell growth GO:0016049 160 0.080
regulation of response to dna damage stimulus GO:2001020 94 0.079
neurogenesis GO:0022008 169 0.078
response to oxygen containing compound GO:1901700 369 0.076
establishment of protein localization to mitochondrion GO:0072655 22 0.076
purine containing compound catabolic process GO:0072523 411 0.075
negative regulation of neuron death GO:1901215 32 0.074
regulation of purine nucleotide metabolic process GO:1900542 264 0.074
extrinsic apoptotic signaling pathway GO:0097191 119 0.073
response to cytokine GO:0034097 232 0.072
regulation of neuron apoptotic process GO:0043523 35 0.071
ribonucleoside triphosphate metabolic process GO:0009199 412 0.071
cellular response to misfolded protein GO:0071218 2 0.070
ribonucleotide catabolic process GO:0009261 405 0.069
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.068
positive regulation of developmental process GO:0051094 314 0.068
peptidyl serine phosphorylation GO:0018105 101 0.068
protein autophosphorylation GO:0046777 123 0.067
negative regulation of neuron apoptotic process GO:0043524 23 0.066
single organism reproductive process GO:0044702 98 0.065
signal transduction by phosphorylation GO:0023014 297 0.065
regulation of cell cycle process GO:0010564 266 0.064
purine nucleotide catabolic process GO:0006195 405 0.063
positive regulation of protein phosphorylation GO:0001934 313 0.063
g2 dna damage checkpoint GO:0031572 26 0.063
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.062
regulation of cytokine production GO:0001817 232 0.062
negative regulation of phosphorus metabolic process GO:0010563 267 0.062
regulation of map kinase activity GO:0043405 108 0.060
response to growth factor GO:0070848 205 0.060
positive regulation of peptidase activity GO:0010952 88 0.058
positive regulation of transferase activity GO:0051347 227 0.058
Mouse
negative regulation of mitotic cell cycle GO:0045930 102 0.057
trna modification GO:0006400 10 0.057
neuron death GO:0070997 65 0.055
amine metabolic process GO:0009308 44 0.055
actin cytoskeleton organization GO:0030036 207 0.054
Worm
immune response activating signal transduction GO:0002757 90 0.053
regulation of nucleoside metabolic process GO:0009118 209 0.053
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 30 0.052
response to organonitrogen compound GO:0010243 156 0.052
negative regulation of catalytic activity GO:0043086 335 0.047
rna modification GO:0009451 27 0.047
ras protein signal transduction GO:0007265 73 0.046
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.046
tor signaling GO:0031929 39 0.046
regulation of transferase activity GO:0051338 355 0.045
Mouse
positive regulation of organelle organization GO:0010638 195 0.045
actin filament based process GO:0030029 224 0.045
Worm
dna integrity checkpoint GO:0031570 71 0.044
response to light stimulus GO:0009416 87 0.044
negative regulation of cell cycle phase transition GO:1901988 89 0.043
positive regulation of hydrolase activity GO:0051345 331 0.043
regulation of growth GO:0040008 165 0.043
negative regulation of intracellular signal transduction GO:1902532 183 0.043
positive regulation of neurogenesis GO:0050769 49 0.042
cell adhesion GO:0007155 325 0.042
intracellular protein transmembrane transport GO:0065002 24 0.042
ribonucleoside triphosphate catabolic process GO:0009203 391 0.042
stress activated mapk cascade GO:0051403 93 0.042
single organism cellular localization GO:1902580 332 0.042
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.042
regulation of response to external stimulus GO:0032101 222 0.040
regulation of protein serine threonine kinase activity GO:0071900 179 0.040
cell projection morphogenesis GO:0048858 129 0.040
positive regulation of immune response GO:0050778 159 0.039
nucleoside triphosphate metabolic process GO:0009141 422 0.039
cellular macromolecular complex assembly GO:0034622 324 0.039
innate immune response GO:0045087 178 0.039
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.039
positive regulation of neuron differentiation GO:0045666 40 0.038
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.038
regulation of locomotion GO:0040012 329 0.037
establishment of protein localization to organelle GO:0072594 172 0.037
positive regulation of cellular component organization GO:0051130 376 0.036
cell morphogenesis GO:0000902 296 0.036
response to metal ion GO:0010038 84 0.036
positive regulation of cytokine production GO:0001819 167 0.035
negative regulation of protein processing GO:0010955 142 0.035
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.035
positive regulation of nucleotide catabolic process GO:0030813 185 0.035
ribonucleoside catabolic process GO:0042454 406 0.034
oocyte development GO:0048599 1 0.034
positive regulation of cell development GO:0010720 92 0.034
regulation of protein maturation GO:1903317 150 0.033
embryonic placenta development GO:0001892 1 0.032
cotranslational protein targeting to membrane GO:0006613 2 0.032
vesicle mediated transport GO:0016192 371 0.032
histone modification GO:0016570 251 0.032
purine nucleoside triphosphate catabolic process GO:0009146 392 0.032
response to lithium ion GO:0010226 2 0.031
immune response regulating signaling pathway GO:0002764 97 0.031
cellular response to growth factor stimulus GO:0071363 197 0.031
ribonucleoside monophosphate catabolic process GO:0009158 158 0.030
nucleoside catabolic process GO:0009164 408 0.030
dna repair GO:0006281 198 0.029
negative regulation of protein kinase activity GO:0006469 98 0.029
cell morphogenesis involved in differentiation GO:0000904 144 0.029
axonogenesis GO:0007409 31 0.028
regulation of cell migration GO:0030334 289 0.028
response to unfolded protein GO:0006986 24 0.028
Mouse
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.028
protein targeting to membrane GO:0006612 42 0.028
locomotory behavior GO:0007626 1 0.028
neuromuscular junction development GO:0007528 3 0.027
negative regulation of proteolysis GO:0045861 132 0.027
cell cell signaling GO:0007267 155 0.027
negative regulation of cellular component organization GO:0051129 235 0.027
protein polymerization GO:0051258 71 0.027
regulation of cysteine type endopeptidase activity GO:2000116 127 0.026
regulation of tor signaling GO:0032006 30 0.026
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.026
positive regulation of kinase activity GO:0033674 204 0.026
positive regulation of nucleotide metabolic process GO:0045981 230 0.026
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.025
autophagy GO:0006914 88 0.025
regulation of neuron death GO:1901214 56 0.025
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.025
carbohydrate derivative biosynthetic process GO:1901137 207 0.024
response to other organism GO:0051707 261 0.024
chromatin organization GO:0006325 351 0.024
regulation of cell motility GO:2000145 299 0.024
positive regulation of neuron projection development GO:0010976 34 0.024
posttranscriptional regulation of gene expression GO:0010608 213 0.023
gtp catabolic process GO:0006184 237 0.023
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.023
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.023
skin development GO:0043588 76 0.023
mitochondrial transport GO:0006839 60 0.023
positive regulation of locomotion GO:0040017 186 0.023
inflammatory response GO:0006954 79 0.023
positive regulation of protein polymerization GO:0032273 45 0.022
cellular amino acid metabolic process GO:0006520 116 0.022
negative regulation of protein modification by small protein conjugation or removal GO:1903321 41 0.022
negative regulation of striated muscle cell apoptotic process GO:0010664 2 0.022
small gtpase mediated signal transduction GO:0007264 78 0.022
response to misfolded protein GO:0051788 5 0.022
negative regulation of growth GO:0045926 97 0.022
protein depolymerization GO:0051261 30 0.022
tube development GO:0035295 125 0.022
response to nutrient levels GO:0031667 81 0.022
cell activation GO:0001775 213 0.021
positive regulation of nervous system development GO:0051962 54 0.021
positive regulation of endopeptidase activity GO:0010950 84 0.021
regulation of cell morphogenesis GO:0022604 153 0.021
retrograde transport endosome to golgi GO:0042147 45 0.021
regulation of innate immune response GO:0045088 97 0.021
regulation of homeostatic process GO:0032844 121 0.020
zymogen activation GO:0031638 70 0.020
inclusion body assembly GO:0070841 17 0.020
enzyme linked receptor protein signaling pathway GO:0007167 303 0.020
regulation of nucleotide metabolic process GO:0006140 269 0.020
mitotic cell cycle GO:0000278 326 0.020
positive regulation of map kinase activity GO:0043406 80 0.020
microtubule cytoskeleton organization GO:0000226 176 0.020
gtp metabolic process GO:0046039 239 0.019
response to temperature stimulus GO:0009266 22 0.019
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.019
regulation of microtubule based process GO:0032886 74 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
microtubule based process GO:0007017 210 0.019
negative regulation of cell cycle process GO:0010948 121 0.019
regulation of protein polymerization GO:0032271 63 0.018
organophosphate catabolic process GO:0046434 430 0.018
cell part morphogenesis GO:0032990 137 0.018
intracellular protein transport GO:0006886 270 0.018
negative regulation of hydrolase activity GO:0051346 182 0.018
heat acclimation GO:0010286 3 0.018
cellular amine metabolic process GO:0044106 41 0.017
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.017
negative regulation of kinase activity GO:0033673 106 0.017
nucleotide catabolic process GO:0009166 408 0.017
regulation of inclusion body assembly GO:0090083 13 0.017
multi organism reproductive process GO:0044703 54 0.017
Worm
chaperone mediated protein folding GO:0061077 13 0.017
regulation of neuron differentiation GO:0045664 70 0.017
regulation of protein complex assembly GO:0043254 147 0.017
cell morphogenesis involved in neuron differentiation GO:0048667 44 0.017
purine ribonucleoside metabolic process GO:0046128 437 0.017
regulation of cellular component biogenesis GO:0044087 281 0.017
head development GO:0060322 108 0.017
small molecule biosynthetic process GO:0044283 157 0.017
nitrogen compound transport GO:0071705 191 0.016
regulation of anatomical structure morphogenesis GO:0022603 286 0.016
mitotic cell cycle process GO:1903047 286 0.016
striated muscle myosin thick filament assembly GO:0071688 2 0.016
regulation of atp metabolic process GO:1903578 29 0.016
negative regulation of peptidase activity GO:0010466 91 0.016
female pregnancy GO:0007565 17 0.016
regulation of viral process GO:0050792 103 0.016
establishment or maintenance of cell polarity GO:0007163 31 0.016
response to drug GO:0042493 81 0.016
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.016
central nervous system development GO:0007417 123 0.016
endocytosis GO:0006897 159 0.015
neuron development GO:0048666 113 0.015
er associated ubiquitin dependent protein catabolic process GO:0030433 31 0.015
cellular response to cytokine stimulus GO:0071345 181 0.015
internal protein amino acid acetylation GO:0006475 101 0.015
reproduction GO:0000003 63 0.015
Worm
negative regulation of fibril organization GO:1902904 1 0.015
response to oxidative stress GO:0006979 121 0.015
protein deubiquitination GO:0016579 79 0.015
post embryonic development GO:0009791 2 0.015
Worm
glycosyl compound catabolic process GO:1901658 413 0.015
multicellular organism reproduction GO:0032504 42 0.015
Worm
axon cargo transport GO:0008088 2 0.015
blood vessel morphogenesis GO:0048514 162 0.014
regulation of ion transport GO:0043269 189 0.014
metal ion transport GO:0030001 272 0.014
macropinocytosis GO:0044351 1 0.014
protein acetylation GO:0006473 116 0.014
regulation of transcription during mitosis GO:0045896 2 0.014
regulation of protein processing GO:0070613 150 0.014
nuclear transport GO:0051169 179 0.014
positive regulation of stress activated mapk cascade GO:0032874 60 0.014
positive regulation of cell size GO:0045793 3 0.013
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.013
cellular response to external stimulus GO:0071496 111 0.013
protein localization to membrane GO:0072657 160 0.013
regulation of cytoskeleton organization GO:0051493 177 0.013
embryo development GO:0009790 123 0.013
protein targeting GO:0006605 187 0.012
negative regulation of map kinase activity GO:0043407 27 0.012
regulation of cell projection organization GO:0031344 107 0.012
positive regulation of dna binding GO:0043388 17 0.012
myosin filament organization GO:0031033 2 0.012
embryo development ending in birth or egg hatching GO:0009792 34 0.012
translation GO:0006412 132 0.012
negative regulation of cell growth GO:0030308 83 0.012
trna processing GO:0008033 23 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.011
regulation of secretion by cell GO:1903530 177 0.011
response to hormone GO:0009725 175 0.011
ribonucleoside monophosphate metabolic process GO:0009161 187 0.011
viral life cycle GO:0019058 132 0.011
receptor mediated endocytosis GO:0006898 84 0.011
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.011
protein homooligomerization GO:0051260 100 0.011
positive regulation of cell projection organization GO:0031346 64 0.011
regulation of ras protein signal transduction GO:0046578 155 0.011
response to fungus GO:0009620 4 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.011
metencephalon development GO:0022037 2 0.011
spermatid differentiation GO:0048515 4 0.011
nuclear division GO:0000280 128 0.011
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.011
regulation of cell cycle phase transition GO:1901987 126 0.011
response to decreased oxygen levels GO:0036293 96 0.011
axon development GO:0061564 34 0.011
positive regulation of meiotic cell cycle GO:0051446 2 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.010
regulation of nervous system development GO:0051960 88 0.010
immune system development GO:0002520 195 0.010
apoptotic mitochondrial changes GO:0008637 57 0.010
neuroblast proliferation GO:0007405 4 0.010
adult locomotory behavior GO:0008344 1 0.010

STUB1 disease predictions

Disease DO term ID Size Probability Func Analog Org
muscular disease DOID:0080000 114 0.394
musculoskeletal system disease DOID:17 223 0.394
muscle tissue disease DOID:66 113 0.394
myopathy DOID:423 104 0.063
central nervous system disease DOID:331 186 0.060
neurodegenerative disease DOID:1289 102 0.060
nervous system disease DOID:863 431 0.060