|
|
endoplasmic reticulum unfolded protein response
|
GO:0030968 |
16 |
1.000
|
Fly |
|
|
cellular response to topologically incorrect protein
|
GO:0035967 |
19 |
0.999
|
Fly |
|
|
response to unfolded protein
|
GO:0006986 |
24 |
0.999
|
Fly |
|
|
er nucleus signaling pathway
|
GO:0006984 |
23 |
0.998
|
Fly |
|
|
cellular response to unfolded protein
|
GO:0034620 |
16 |
0.998
|
Fly |
|
|
response to topologically incorrect protein
|
GO:0035966 |
29 |
0.996
|
Fly |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.995
|
Human Fly |
|
|
response to endoplasmic reticulum stress
|
GO:0034976 |
49 |
0.995
|
Mouse Fly |
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.992
|
|
|
|
modification dependent macromolecule catabolic process
|
GO:0043632 |
212 |
0.991
|
|
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.988
|
Human Fly |
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.977
|
Mouse |
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.957
|
|
|
|
regulation of nuclease activity
|
GO:0032069 |
11 |
0.928
|
|
|
|
proteolysis involved in cellular protein catabolic process
|
GO:0051603 |
244 |
0.916
|
|
|
|
activation of signaling protein activity involved in unfolded protein response
|
GO:0006987 |
3 |
0.907
|
|
|
|
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
|
GO:0070059 |
12 |
0.907
|
Mouse |
|
|
cellular protein catabolic process
|
GO:0044257 |
261 |
0.902
|
|
|
|
ubiquitin dependent protein catabolic process
|
GO:0006511 |
206 |
0.882
|
|
|
|
er associated ubiquitin dependent protein catabolic process
|
GO:0030433 |
31 |
0.854
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.824
|
|
|
|
rrna metabolic process
|
GO:0016072 |
40 |
0.799
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.761
|
|
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.754
|
|
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.747
|
|
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.702
|
Human |
|
|
proteasomal protein catabolic process
|
GO:0010498 |
176 |
0.702
|
|
|
|
cell cycle arrest
|
GO:0007050 |
71 |
0.690
|
|
|
|
rna catabolic process
|
GO:0006401 |
71 |
0.611
|
|
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.594
|
|
|
|
dna packaging
|
GO:0006323 |
77 |
0.552
|
|
|
|
membrane organization
|
GO:0061024 |
292 |
0.527
|
|
|
|
protein deubiquitination
|
GO:0016579 |
79 |
0.526
|
|
|
|
carbohydrate metabolic process
|
GO:0005975 |
207 |
0.518
|
|
|
|
positive regulation of nuclease activity
|
GO:0032075 |
5 |
0.499
|
|
|
|
alcohol metabolic process
|
GO:0006066 |
114 |
0.495
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.487
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.473
|
|
|
|
execution phase of apoptosis
|
GO:0097194 |
32 |
0.451
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.437
|
Human |
|
|
cellular component disassembly
|
GO:0022411 |
92 |
0.436
|
|
|
|
dna conformation change
|
GO:0071103 |
113 |
0.433
|
|
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.422
|
|
|
|
ncrna catabolic process
|
GO:0034661 |
14 |
0.419
|
|
|
|
organic hydroxy compound metabolic process
|
GO:1901615 |
147 |
0.381
|
|
|
|
mrna metabolic process
|
GO:0016071 |
175 |
0.378
|
|
|
|
nucleic acid phosphodiester bond hydrolysis
|
GO:0090305 |
102 |
0.354
|
|
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.351
|
Human |
|
|
histone modification
|
GO:0016570 |
251 |
0.337
|
|
|
|
regulation of intrinsic apoptotic signaling pathway
|
GO:2001242 |
72 |
0.330
|
Mouse |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.293
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.275
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.265
|
|
|
|
chromosome segregation
|
GO:0007059 |
114 |
0.263
|
|
|
|
protein autophosphorylation
|
GO:0046777 |
123 |
0.229
|
|
|
|
dna repair
|
GO:0006281 |
198 |
0.226
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.222
|
Human |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.218
|
Mouse |
|
|
protein modification by small protein removal
|
GO:0070646 |
92 |
0.216
|
|
|
|
microtubule cytoskeleton organization
|
GO:0000226 |
176 |
0.210
|
|
|
|
regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903050 |
91 |
0.206
|
|
|
|
rna splicing
|
GO:0008380 |
131 |
0.204
|
|
|
|
apoptotic nuclear changes
|
GO:0030262 |
13 |
0.196
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.192
|
|
|
|
regulation of endoplasmic reticulum unfolded protein response
|
GO:1900101 |
5 |
0.192
|
|
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.191
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.183
|
|
|
|
chromatin organization
|
GO:0006325 |
351 |
0.183
|
|
|
|
cellular component disassembly involved in execution phase of apoptosis
|
GO:0006921 |
13 |
0.181
|
|
|
|
chromatin modification
|
GO:0016568 |
298 |
0.178
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.176
|
|
|
|
regulation of proteasomal protein catabolic process
|
GO:0061136 |
87 |
0.172
|
|
|
|
regulation of ligase activity
|
GO:0051340 |
29 |
0.169
|
|
|
|
ncrna metabolic process
|
GO:0034660 |
108 |
0.163
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.157
|
|
|
|
mitotic nuclear division
|
GO:0007067 |
119 |
0.150
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.149
|
|
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.148
|
Mouse |
|
|
endomembrane system organization
|
GO:0010256 |
196 |
0.148
|
|
|
|
organelle fission
|
GO:0048285 |
149 |
0.148
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.146
|
|
|
|
protein maturation
|
GO:0051604 |
233 |
0.142
|
Human |
|
|
response to radiation
|
GO:0009314 |
151 |
0.141
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.139
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.138
|
Mouse |
|
|
positive regulation of endoplasmic reticulum unfolded protein response
|
GO:1900103 |
4 |
0.138
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.138
|
|
|
|
cellular response to misfolded protein
|
GO:0071218 |
2 |
0.137
|
|
|
|
ribonucleoside monophosphate metabolic process
|
GO:0009161 |
187 |
0.135
|
|
|
|
protein acylation
|
GO:0043543 |
138 |
0.132
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.130
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.127
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.124
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.114
|
|
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.114
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.110
|
|
|
|
cell development
|
GO:0048468 |
328 |
0.105
|
|
|
|
inositol metabolic process
|
GO:0006020 |
3 |
0.103
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.103
|
Mouse |
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.101
|
|
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.101
|
Mouse |
|
|
protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:0042787 |
37 |
0.101
|
|
|
|
rna splicing via endonucleolytic cleavage and ligation
|
GO:0000394 |
8 |
0.100
|
|
|
|
regulation of potassium ion transmembrane transport
|
GO:1901379 |
20 |
0.098
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.095
|
|
|
|
positive regulation of protein modification by small protein conjugation or removal
|
GO:1903322 |
61 |
0.095
|
|
|
|
histone acetylation
|
GO:0016573 |
93 |
0.094
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.093
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.092
|
|
|
|
regulation of metal ion transport
|
GO:0010959 |
120 |
0.092
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.091
|
Human |
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.091
|
|
|
|
positive regulation of protein ubiquitination
|
GO:0031398 |
53 |
0.091
|
|
|
|
chromosome condensation
|
GO:0030261 |
15 |
0.090
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.089
|
|
|
|
regulation of rna splicing
|
GO:0043484 |
62 |
0.089
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.089
|
|
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.088
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.086
|
|
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.085
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.080
|
|
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.080
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.077
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.077
|
|
|
|
oocyte differentiation
|
GO:0009994 |
2 |
0.077
|
|
|
|
positive regulation of mesenchymal stem cell differentiation
|
GO:2000741 |
4 |
0.077
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.077
|
|
|
|
golgi organization
|
GO:0007030 |
38 |
0.076
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.076
|
|
|
|
regulation of ion transmembrane transport
|
GO:0034765 |
132 |
0.075
|
|
|
|
mitotic sister chromatid segregation
|
GO:0000070 |
53 |
0.074
|
|
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.074
|
|
|
|
protein monoubiquitination
|
GO:0006513 |
39 |
0.073
|
|
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.072
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.069
|
|
|
|
positive regulation of calcium ion transport
|
GO:0051928 |
51 |
0.068
|
|
|
|
rrna catabolic process
|
GO:0016075 |
6 |
0.068
|
|
|
|
developmental programmed cell death
|
GO:0010623 |
3 |
0.066
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.066
|
|
|
|
regulation of mitosis
|
GO:0007088 |
63 |
0.065
|
|
|
|
regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000058 |
7 |
0.064
|
|
|
|
mitotic cell cycle process
|
GO:1903047 |
286 |
0.064
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.063
|
|
|
|
negative regulation of chromosome organization
|
GO:2001251 |
48 |
0.063
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.062
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.061
|
|
|
|
negative regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903051 |
35 |
0.060
|
|
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.060
|
|
|
|
response to ionizing radiation
|
GO:0010212 |
65 |
0.060
|
|
|
|
covalent chromatin modification
|
GO:0016569 |
254 |
0.060
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.059
|
|
|
|
regulation of cellular component size
|
GO:0032535 |
82 |
0.058
|
|
|
|
embryonic camera type eye development
|
GO:0031076 |
2 |
0.057
|
|
|
|
retrograde protein transport er to cytosol
|
GO:0030970 |
5 |
0.056
|
|
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.056
|
|
|
|
rna processing
|
GO:0006396 |
255 |
0.055
|
|
|
|
positive regulation of axon extension
|
GO:0045773 |
4 |
0.055
|
|
|
|
negative regulation of intrinsic apoptotic signaling pathway
|
GO:2001243 |
40 |
0.055
|
Mouse |
|
|
negative regulation of proteasomal protein catabolic process
|
GO:1901799 |
32 |
0.054
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.054
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.053
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.052
|
|
|
|
purine nucleoside monophosphate metabolic process
|
GO:0009126 |
186 |
0.052
|
|
|
|
maintenance of protein location
|
GO:0045185 |
57 |
0.051
|
|
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.051
|
|
|
|
establishment of protein localization to membrane
|
GO:0090150 |
121 |
0.051
|
|
|
|
trabecula morphogenesis
|
GO:0061383 |
2 |
0.050
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.049
|
|
|
|
nuclear division
|
GO:0000280 |
128 |
0.048
|
|
|
|
histone h4 k12 acetylation
|
GO:0043983 |
6 |
0.048
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.048
|
Human |
|
|
regulation of protein stability
|
GO:0031647 |
87 |
0.048
|
|
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.048
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.047
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.047
|
|
|
|
positive regulation of locomotion
|
GO:0040017 |
186 |
0.046
|
|
|
|
histone h3 acetylation
|
GO:0043966 |
45 |
0.044
|
|
|
|
double strand break repair
|
GO:0006302 |
101 |
0.044
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.044
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.044
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.044
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.043
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.043
|
|
|
|
negative regulation of catabolic process
|
GO:0009895 |
104 |
0.043
|
|
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.043
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.042
|
|
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.042
|
|
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.041
|
|
|
|
maintenance of protein localization in organelle
|
GO:0072595 |
15 |
0.041
|
|
|
|
purine containing compound catabolic process
|
GO:0072523 |
411 |
0.040
|
|
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.040
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.040
|
|
|
|
purine ribonucleoside monophosphate catabolic process
|
GO:0009169 |
158 |
0.040
|
|
|
|
atp catabolic process
|
GO:0006200 |
157 |
0.040
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.039
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.039
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.039
|
Human |
|
|
regulation of histone modification
|
GO:0031056 |
47 |
0.039
|
|
|
|
embryonic camera type eye morphogenesis
|
GO:0048596 |
2 |
0.039
|
|
|
|
negative regulation of cellular protein catabolic process
|
GO:1903363 |
38 |
0.038
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.038
|
|
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.038
|
|
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.038
|
|
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.038
|
|
|
|
regulation of developmental growth
|
GO:0048638 |
30 |
0.037
|
|
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.037
|
|
|
|
purine ribonucleoside monophosphate metabolic process
|
GO:0009167 |
186 |
0.037
|
|
|
|
cellular response to hypoxia
|
GO:0071456 |
51 |
0.037
|
|
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.037
|
Human |
|
|
dna damage response signal transduction resulting in transcription
|
GO:0042772 |
12 |
0.037
|
|
|
|
locomotory behavior
|
GO:0007626 |
1 |
0.036
|
|
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.036
|
|
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.036
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.036
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.036
|
|
|
|
response to toxic substance
|
GO:0009636 |
37 |
0.036
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.036
|
|
|
|
establishment of monopolar cell polarity
|
GO:0061162 |
1 |
0.036
|
|
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.036
|
|
|
|
rna phosphodiester bond hydrolysis endonucleolytic
|
GO:0090502 |
15 |
0.036
|
|
|
|
ribonucleoside monophosphate catabolic process
|
GO:0009158 |
158 |
0.036
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.035
|
|
|
|
regulation of mitotic metaphase anaphase transition
|
GO:0030071 |
26 |
0.035
|
|
|
|
regulation of response to dna damage stimulus
|
GO:2001020 |
94 |
0.035
|
|
|
|
negative regulation of protein ubiquitination
|
GO:0031397 |
35 |
0.035
|
|
|
|
metal ion transport
|
GO:0030001 |
272 |
0.035
|
|
|
|
peptidyl lysine acetylation
|
GO:0018394 |
101 |
0.034
|
|
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.034
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.034
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.034
|
Mouse |
|
|
positive regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032436 |
30 |
0.034
|
|
|
|
cell migration involved in gastrulation
|
GO:0042074 |
1 |
0.033
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.033
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.033
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.033
|
|
|
|
negative regulation of protein ubiquitination involved in ubiquitin dependent protein catabolic process
|
GO:2000059 |
3 |
0.033
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.033
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.032
|
|
|
|
negative regulation of protein catabolic process
|
GO:0042177 |
59 |
0.032
|
|
|
|
regulation of protein polymerization
|
GO:0032271 |
63 |
0.032
|
|
|
|
regulation of gene expression epigenetic
|
GO:0040029 |
73 |
0.032
|
|
|
|
hindbrain development
|
GO:0030902 |
3 |
0.032
|
|
|
|
cellular response to oxidative stress
|
GO:0034599 |
85 |
0.032
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.032
|
|
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.032
|
|
|
|
nucleus organization
|
GO:0006997 |
28 |
0.031
|
|
|
|
response to light stimulus
|
GO:0009416 |
87 |
0.031
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.031
|
|
|
|
sister chromatid segregation
|
GO:0000819 |
54 |
0.031
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.031
|
|
|
|
purine nucleoside monophosphate catabolic process
|
GO:0009128 |
158 |
0.031
|
|
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.031
|
|
|
|
organelle localization
|
GO:0051640 |
84 |
0.031
|
|
|
|
regulation of chromosome organization
|
GO:0033044 |
103 |
0.031
|
|
|
|
internal peptidyl lysine acetylation
|
GO:0018393 |
97 |
0.030
|
|
|
|
compound eye development
|
GO:0048749 |
1 |
0.030
|
|
|
|
chemotaxis
|
GO:0006935 |
157 |
0.030
|
|
|
|
heart morphogenesis
|
GO:0003007 |
48 |
0.030
|
|
|
|
inner ear morphogenesis
|
GO:0042472 |
4 |
0.030
|
|
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.030
|
|
|
|
chromosome separation
|
GO:0051304 |
23 |
0.029
|
|
|
|
positive regulation of response to external stimulus
|
GO:0032103 |
88 |
0.029
|
|
|
|
glycoprotein biosynthetic process
|
GO:0009101 |
91 |
0.029
|
|
|
|
hypothalamus development
|
GO:0021854 |
1 |
0.029
|
|
|
|
protein acetylation
|
GO:0006473 |
116 |
0.029
|
|
|
|
peptidyl lysine modification
|
GO:0018205 |
144 |
0.028
|
|
|
|
intrinsic apoptotic signaling pathway in response to dna damage
|
GO:0008630 |
50 |
0.028
|
|
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.028
|
|
|
|
peptidyl tyrosine phosphorylation
|
GO:0018108 |
170 |
0.028
|
|
|
|
defense response
|
GO:0006952 |
315 |
0.028
|
|
|
|
toxin transport
|
GO:1901998 |
4 |
0.027
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.027
|
|
|
|
cell cycle checkpoint
|
GO:0000075 |
117 |
0.027
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.027
|
|
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.027
|
|
|
|
positive regulation of growth
|
GO:0045927 |
58 |
0.027
|
|
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.027
|
|
|
|
store operated calcium entry
|
GO:0002115 |
3 |
0.026
|
|
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.026
|
|
|
|
establishment of organelle localization
|
GO:0051656 |
59 |
0.026
|
|
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.026
|
Mouse |
|
|
signal transduction by p53 class mediator
|
GO:0072331 |
72 |
0.026
|
|
|
|
spinal cord development
|
GO:0021510 |
4 |
0.026
|
|
|
|
maintenance of protein location in cell
|
GO:0032507 |
56 |
0.026
|
|
|
|
atp metabolic process
|
GO:0046034 |
176 |
0.026
|
|
|
|
regulation of chromatin modification
|
GO:1903308 |
51 |
0.026
|
|
|
|
dna damage response signal transduction by p53 class mediator
|
GO:0030330 |
44 |
0.026
|
|
|
|
regulation of cell division
|
GO:0051302 |
116 |
0.026
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.026
|
|
|
|
intrinsic apoptotic signaling pathway by p53 class mediator
|
GO:0072332 |
37 |
0.025
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.025
|
|
|
|
signal transduction in response to dna damage
|
GO:0042770 |
57 |
0.025
|
|
|
|
positive regulation of chromatin modification
|
GO:1903310 |
30 |
0.025
|
|
|
|
regulation of ubiquitin protein transferase activity
|
GO:0051438 |
28 |
0.025
|
|
|
|
nucleoside monophosphate catabolic process
|
GO:0009125 |
159 |
0.024
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.024
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.024
|
|
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.024
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.024
|
|
|
|
cytokinesis
|
GO:0000910 |
96 |
0.024
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.024
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.024
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.024
|
|
|
|
epidermis morphogenesis
|
GO:0048730 |
3 |
0.024
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.024
|
|
|
|
androgen biosynthetic process
|
GO:0006702 |
3 |
0.024
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.024
|
|
|
|
response to misfolded protein
|
GO:0051788 |
5 |
0.024
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.024
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.024
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.023
|
|
|
|
nuclear envelope reassembly
|
GO:0031468 |
3 |
0.023
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.023
|
|
|
|
nucleoside monophosphate metabolic process
|
GO:0009123 |
191 |
0.023
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.023
|
|
|
|
negative regulation of kinase activity
|
GO:0033673 |
106 |
0.023
|
|
|
|
negative regulation of cellular catabolic process
|
GO:0031330 |
83 |
0.023
|
|
|
|
ventricular trabecula myocardium morphogenesis
|
GO:0003222 |
1 |
0.023
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.023
|
|
|
|
morphogenesis of embryonic epithelium
|
GO:0016331 |
4 |
0.023
|
|
|
|
mitotic sister chromatid separation
|
GO:0051306 |
18 |
0.023
|
|
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.023
|
|
|
|
cellular response to nutrient levels
|
GO:0031669 |
69 |
0.023
|
|
|
|
glucan metabolic process
|
GO:0044042 |
22 |
0.023
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.023
|
|
|
|
positive regulation of cell projection organization
|
GO:0031346 |
64 |
0.022
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.022
|
|
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.022
|
|
|
|
system process
|
GO:0003008 |
349 |
0.022
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.022
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.022
|
|
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.022
|
Mouse |
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.022
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.022
|
|
|
|
negative regulation of organelle organization
|
GO:0010639 |
126 |
0.022
|
|
|
|
energy homeostasis
|
GO:0097009 |
3 |
0.022
|
|
|
|
response to organic cyclic compound
|
GO:0014070 |
204 |
0.022
|
|
|
|
actin filament organization
|
GO:0007015 |
128 |
0.021
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.021
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.021
|
|
|
|
apoptotic process involved in morphogenesis
|
GO:0060561 |
3 |
0.021
|
|
|
|
steroid biosynthetic process
|
GO:0006694 |
46 |
0.021
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.021
|
|
|
|
multicellular organismal homeostasis
|
GO:0048871 |
67 |
0.021
|
|
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
48 |
0.021
|
|
|
|
metaphase anaphase transition of mitotic cell cycle
|
GO:0007091 |
21 |
0.021
|
|
|
|
response to uv
|
GO:0009411 |
73 |
0.021
|
|
|
|
regulation of cytokine mediated signaling pathway
|
GO:0001959 |
41 |
0.021
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.021
|
|
|
|
monovalent inorganic cation homeostasis
|
GO:0055067 |
37 |
0.021
|
|
|
|
positive regulation of proteolysis involved in cellular protein catabolic process
|
GO:1903052 |
35 |
0.021
|
|
|
|
retina layer formation
|
GO:0010842 |
3 |
0.021
|
|
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.021
|
|
|
|
establishment of nucleus localization
|
GO:0040023 |
1 |
0.021
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.021
|
|
|
|
maturation of 5 8s rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna
|
GO:0000466 |
2 |
0.021
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.021
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.020
|
|
|
|
chondrocyte development
|
GO:0002063 |
1 |
0.020
|
|
|
|
negative regulation of chromatin modification
|
GO:1903309 |
21 |
0.020
|
|
|
|
protein secretion
|
GO:0009306 |
98 |
0.020
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.020
|
|
|
|
regulation of neuronal synaptic plasticity
|
GO:0048168 |
1 |
0.020
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.020
|
|
|
|
peptidyl tyrosine modification
|
GO:0018212 |
170 |
0.020
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.020
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.020
|
|
|
|
er associated misfolded protein catabolic process
|
GO:0071712 |
1 |
0.020
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.020
|
|
|
|
establishment or maintenance of bipolar cell polarity
|
GO:0061245 |
2 |
0.020
|
|
|
|
response to drug
|
GO:0042493 |
81 |
0.019
|
|
|
|
taxis
|
GO:0042330 |
157 |
0.019
|
|
|
|
negative regulation of protein kinase activity
|
GO:0006469 |
98 |
0.019
|
|
|
|
response to oxidative stress
|
GO:0006979 |
121 |
0.019
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.019
|
|
|
|
cytoskeleton dependent cytokinesis
|
GO:0061640 |
22 |
0.019
|
|
|
|
positive regulation of ubiquitin protein transferase activity
|
GO:0051443 |
18 |
0.019
|
|
|
|
positive regulation of ion transport
|
GO:0043270 |
87 |
0.019
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.019
|
|
|
|
notch signaling pathway
|
GO:0007219 |
31 |
0.019
|
|
|
|
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process
|
GO:0031145 |
25 |
0.018
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.018
|
|
|
|
lens development in camera type eye
|
GO:0002088 |
2 |
0.018
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.018
|
|
|
|
negative regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032435 |
30 |
0.018
|
|
|
|
protein k63 linked deubiquitination
|
GO:0070536 |
21 |
0.018
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.018
|
|
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.018
|
|
|
|
regulation of mitotic cell cycle
|
GO:0007346 |
189 |
0.018
|
|
|
|
establishment of apical basal cell polarity
|
GO:0035089 |
1 |
0.018
|
|
|
|
regulation of sister chromatid segregation
|
GO:0033045 |
27 |
0.018
|
|
|
|
negative regulation of response to dna damage stimulus
|
GO:2001021 |
33 |
0.018
|
|
|
|
vesicle organization
|
GO:0016050 |
62 |
0.018
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.018
|
|
|
|
positive regulation of cellular component biogenesis
|
GO:0044089 |
158 |
0.018
|
|
|
|
cellular response to radiation
|
GO:0071478 |
65 |
0.018
|
|
|
|
sodium ion transmembrane transport
|
GO:0035725 |
59 |
0.018
|
|
|
|
autophagy
|
GO:0006914 |
88 |
0.017
|
|
|
|
negative regulation of axonogenesis
|
GO:0050771 |
4 |
0.017
|
|
|
|
cellular response to oxygen levels
|
GO:0071453 |
55 |
0.017
|
|
|
|
protein polymerization
|
GO:0051258 |
71 |
0.017
|
|
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.017
|
|
|
|
establishment or maintenance of monopolar cell polarity
|
GO:0061339 |
1 |
0.017
|
|
|
|
cellular response to alcohol
|
GO:0097306 |
29 |
0.017
|
|
|
|
negative regulation of mitotic metaphase anaphase transition
|
GO:0045841 |
17 |
0.017
|
|
|
|
protein n linked glycosylation via asparagine
|
GO:0018279 |
10 |
0.017
|
|
|
|
retrograde transport endosome to golgi
|
GO:0042147 |
45 |
0.017
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.017
|
|
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.017
|
|
|
|
peptidyl asparagine modification
|
GO:0018196 |
11 |
0.017
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.017
|
|
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.017
|
|
|
|
steroid metabolic process
|
GO:0008202 |
94 |
0.017
|
|
|
|
membrane fusion
|
GO:0061025 |
43 |
0.017
|
|
|
|
positive regulation of neuron differentiation
|
GO:0045666 |
40 |
0.016
|
|
|
|
regulation of response to oxidative stress
|
GO:1902882 |
26 |
0.016
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.016
|
|
|
|
cellular response to ionizing radiation
|
GO:0071479 |
32 |
0.016
|
|
|
|
cellular response to organic cyclic compound
|
GO:0071407 |
127 |
0.016
|
|
|
|
regulation of leukocyte proliferation
|
GO:0070663 |
67 |
0.016
|
|
|
|
dna replication
|
GO:0006260 |
116 |
0.016
|
|
|
|
regulation of actin filament length
|
GO:0030832 |
56 |
0.016
|
|
|
|
positive regulation of dendrite morphogenesis
|
GO:0050775 |
3 |
0.016
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.016
|
|
|
|
protein folding
|
GO:0006457 |
38 |
0.016
|
|
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.016
|
|
|
|
regulation of cell projection organization
|
GO:0031344 |
107 |
0.016
|
|
|
|
histone h2b conserved c terminal lysine deubiquitination
|
GO:0035616 |
1 |
0.016
|
|
|
|
positive regulation of epithelial cell proliferation
|
GO:0050679 |
65 |
0.016
|
|
|
|
response to lipid
|
GO:0033993 |
206 |
0.016
|
|
|
|
cellular response to extracellular stimulus
|
GO:0031668 |
72 |
0.016
|
|
|
|
response to nutrient levels
|
GO:0031667 |
81 |
0.016
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.016
|
|
|
|
histone h4 k5 acetylation
|
GO:0043981 |
15 |
0.016
|
|
|
|
growth
|
GO:0040007 |
202 |
0.015
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.015
|
|
|
|
t cell activation
|
GO:0042110 |
99 |
0.015
|
|
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.015
|
|
|
|
response to alcohol
|
GO:0097305 |
64 |
0.015
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.015
|
|
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.015
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.015
|
|
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.015
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.015
|
|
|
|
mitotic metaphase plate congression
|
GO:0007080 |
14 |
0.015
|
|
|
|
mitotic cell cycle phase transition
|
GO:0044772 |
162 |
0.015
|
|
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
45 |
0.015
|
|
|
|
organic hydroxy compound biosynthetic process
|
GO:1901617 |
71 |
0.015
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.015
|
|
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.015
|
Human |
|
|
embryonic organ morphogenesis
|
GO:0048562 |
24 |
0.015
|
|
|
|
substantia nigra development
|
GO:0021762 |
45 |
0.015
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.015
|
|
|
|
microtubule anchoring
|
GO:0034453 |
24 |
0.015
|
|
|
|
negative regulation of mitotic cell cycle phase transition
|
GO:1901991 |
85 |
0.015
|
|
|
|
actin polymerization or depolymerization
|
GO:0008154 |
56 |
0.015
|
|
|
|
meiotic chromosome segregation
|
GO:0045132 |
4 |
0.015
|
|
|
|
positive regulation of ligase activity
|
GO:0051351 |
19 |
0.015
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.015
|
|
|
|
regulation of cell cycle process
|
GO:0010564 |
266 |
0.015
|
|
|
|
vitamin d receptor signaling pathway
|
GO:0070561 |
4 |
0.015
|
|
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.015
|
|
|
|
epidermis development
|
GO:0008544 |
59 |
0.014
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.014
|
|
|
|
induction of negative chemotaxis
|
GO:0050929 |
1 |
0.014
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.014
|
|
|
|
regulation of actin polymerization or depolymerization
|
GO:0008064 |
56 |
0.014
|
|
|
|
developmental growth
|
GO:0048589 |
48 |
0.014
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.014
|
|
|
|
regulation of chromatin organization
|
GO:1902275 |
56 |
0.014
|
|
|
|
positive regulation of neuron projection development
|
GO:0010976 |
34 |
0.014
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
84 |
0.014
|
|
|
|
regulation of protein acetylation
|
GO:1901983 |
25 |
0.014
|
|
|
|
bone mineralization
|
GO:0030282 |
34 |
0.014
|
|
|
|
neuron development
|
GO:0048666 |
113 |
0.014
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.014
|
|
|
|
regulation of mesenchymal stem cell proliferation
|
GO:1902460 |
1 |
0.014
|
|
|
|
rna interference
|
GO:0016246 |
4 |
0.014
|
|
|
|
regulation of actin filament polymerization
|
GO:0030833 |
50 |
0.014
|
|
|
|
cellular response to heparin
|
GO:0071504 |
2 |
0.014
|
|
|
|
negative regulation of protein serine threonine kinase activity
|
GO:0071901 |
57 |
0.014
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.014
|
|
|
|
positive regulation of stem cell differentiation
|
GO:2000738 |
29 |
0.014
|
|
|
|
generation of neurons
|
GO:0048699 |
152 |
0.014
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.014
|
|
