Homo sapiens

63 known processes

TCF4

transcription factor 4

(Aliases: SEF2,bHLHb19,PTHS,SEF2-1A,SEF2-1B,SEF2-1,ITF2,E2-2,MGC149724,MGC149723)

TCF4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.988
Human Mouse
neuroendocrine cell differentiation GO:0061101 2 0.953
Fly
forebrain generation of neurons GO:0021872 3 0.948
organ morphogenesis GO:0009887 147 0.917
Worm Fly
hair follicle morphogenesis GO:0031069 2 0.895
pituitary gland development GO:0021983 2 0.894
cell development GO:0048468 328 0.881
Mouse Worm Fly
canonical wnt signaling pathway involved in negative regulation of apoptotic process GO:0044336 2 0.873
negative regulation of multicellular organismal process GO:0051241 317 0.871
wnt signaling pathway GO:0016055 156 0.868
taxis GO:0042330 157 0.863
heart formation GO:0060914 2 0.839
chemotaxis GO:0006935 157 0.833
regulation of canonical wnt signaling pathway GO:0060828 88 0.832
cerebral cortex gabaergic interneuron differentiation GO:0021892 1 0.830
sex determination GO:0007530 3 0.826
cellular response to endogenous stimulus GO:0071495 336 0.808
epithelial cell proliferation GO:0050673 128 0.785
midgut development GO:0007494 1 0.780
regulation of locomotion GO:0040012 329 0.772
angiogenesis GO:0001525 147 0.756
cellular component morphogenesis GO:0032989 314 0.720
vasculature development GO:0001944 181 0.717
tongue development GO:0043586 1 0.714
positive regulation of proteoglycan biosynthetic process GO:1902730 3 0.712
regulation of cell motility GO:2000145 299 0.708
stem cell differentiation GO:0048863 93 0.706
Worm Fly
hindbrain development GO:0030902 3 0.698
cell fate determination GO:0001709 3 0.696
regulation of cell development GO:0060284 161 0.696
Mouse
cell matrix adhesion GO:0007160 85 0.689
neuron differentiation GO:0030182 138 0.688
Mouse Worm Fly
blood vessel morphogenesis GO:0048514 162 0.686
regulation of cell cell adhesion GO:0022407 57 0.684
anatomical structure formation involved in morphogenesis GO:0048646 284 0.675
blood vessel development GO:0001568 172 0.675
cell morphogenesis involved in differentiation GO:0000904 144 0.667
post embryonic development GO:0009791 2 0.661
Worm
generation of neurons GO:0048699 152 0.650
Mouse Worm Fly
cell activation GO:0001775 213 0.628
Human
neuroblast proliferation GO:0007405 4 0.618
muscle tissue development GO:0060537 62 0.614
neuron fate commitment GO:0048663 2 0.608
Fly
cerebral cortex radially oriented cell migration GO:0021799 1 0.605
cellular response to transforming growth factor beta stimulus GO:0071560 94 0.602
cellular response to growth factor stimulus GO:0071363 197 0.593
cardiac muscle cell cardiac muscle cell adhesion GO:0086042 1 0.581
negative regulation of interleukin 5 production GO:0032714 3 0.572
regulation of cell migration GO:0030334 289 0.562
response to lipid GO:0033993 206 0.557
positive regulation of osteoblast differentiation GO:0045669 23 0.555
heart field specification GO:0003128 2 0.549
nephron tubule formation GO:0072079 1 0.523
forebrain neuron differentiation GO:0021879 3 0.516
embryonic organ development GO:0048568 36 0.515
regulation of neurogenesis GO:0050767 82 0.514
Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.514
lung cell differentiation GO:0060479 1 0.512
kidney development GO:0001822 53 0.509
response to growth factor GO:0070848 205 0.498
nephron tubule epithelial cell differentiation GO:0072160 3 0.498
response to transforming growth factor beta GO:0071559 94 0.497
circulatory system development GO:0072359 262 0.497
gabaergic neuron differentiation GO:0097154 1 0.496
cardiac muscle tissue development GO:0048738 39 0.494
pharynx development GO:0060465 1 0.485
keratinocyte proliferation GO:0043616 17 0.484
spinal cord development GO:0021510 4 0.482
regulation of endothelial cell differentiation GO:0045601 4 0.479
digestive system development GO:0055123 75 0.477
renal vesicle morphogenesis GO:0072077 4 0.476
positive regulation of locomotion GO:0040017 186 0.475
embryonic organ morphogenesis GO:0048562 24 0.473
ameboidal type cell migration GO:0001667 135 0.467
regulation of cell adhesion GO:0030155 166 0.466
enzyme linked receptor protein signaling pathway GO:0007167 303 0.465
positive regulation of cellular component movement GO:0051272 181 0.461
cell morphogenesis GO:0000902 296 0.458
response to wounding GO:0009611 168 0.455
heart morphogenesis GO:0003007 48 0.446
patterning of blood vessels GO:0001569 2 0.442
positive regulation of cell cycle GO:0045787 140 0.440
Human
positive regulation of developmental process GO:0051094 314 0.437
Mouse Worm
coagulation GO:0050817 78 0.437
regulation of anatomical structure morphogenesis GO:0022603 286 0.435
urogenital system development GO:0001655 65 0.434
Fly
positive regulation of cell proliferation GO:0008284 301 0.432
Human
regulation of glycoprotein metabolic process GO:1903018 19 0.423
positive regulation of keratinocyte proliferation GO:0010838 4 0.421
cerebral cortex cell migration GO:0021795 3 0.417
peripheral nervous system development GO:0007422 2 0.412
canonical wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition GO:0044334 2 0.410
regeneration GO:0031099 4 0.409
negative regulation of cell fate commitment GO:0010454 3 0.408
motor neuron axon guidance GO:0008045 2 0.408
regulation of epithelial cell proliferation GO:0050678 113 0.407
cardiac ventricle formation GO:0003211 2 0.402
tissue morphogenesis GO:0048729 96 0.398
platelet aggregation GO:0070527 32 0.394
canonical wnt signaling pathway GO:0060070 116 0.393
response to oxygen containing compound GO:1901700 369 0.390
lung associated mesenchyme development GO:0060484 1 0.388
negative regulation of cell differentiation GO:0045596 171 0.381
Fly
regulation of cell cycle GO:0051726 393 0.381
Human
cardiovascular system development GO:0072358 262 0.378
renal vesicle development GO:0072087 4 0.377
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.376
muscle structure development GO:0061061 98 0.376
positive regulation of cell motility GO:2000147 177 0.372
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.368
negative regulation of wnt signaling pathway GO:0030178 69 0.362
positive regulation of cell migration GO:0030335 172 0.361
heparan sulfate proteoglycan biosynthetic process GO:0015012 8 0.361
cell differentiation in spinal cord GO:0021515 1 0.353
focal adhesion assembly GO:0048041 30 0.352
positive regulation of apoptotic process GO:0043065 246 0.351
tube development GO:0035295 125 0.351
Fly
transforming growth factor beta receptor signaling pathway GO:0007179 76 0.341
tube morphogenesis GO:0035239 95 0.340
defense response to bacterium GO:0042742 63 0.333
regulation of cell projection organization GO:0031344 107 0.333
heart development GO:0007507 95 0.330
hematopoietic or lymphoid organ development GO:0048534 186 0.327
Human
leukocyte differentiation GO:0002521 98 0.324
Human
osteoblast differentiation GO:0001649 92 0.321
cell migration involved in gastrulation GO:0042074 1 0.318
forelimb morphogenesis GO:0035136 4 0.317
somitogenesis GO:0001756 2 0.316
digestive tract development GO:0048565 75 0.316
regulation of neuron differentiation GO:0045664 70 0.312
Mouse
mesenchymal cell development GO:0014031 50 0.312
nervous system development GO:0007399 293 0.307
Mouse Worm Fly
cell type specific apoptotic process GO:0097285 125 0.306
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.303
chordate embryonic development GO:0043009 34 0.302
neurogenesis GO:0022008 169 0.301
Mouse Worm Fly
specification of organ identity GO:0010092 3 0.295
noradrenergic neuron differentiation GO:0003357 1 0.289
locomotory behavior GO:0007626 1 0.289
regulation of phagocytosis engulfment GO:0060099 2 0.287
myosin filament assembly GO:0031034 2 0.287
mesenchymal cell differentiation GO:0048762 52 0.286
cell chemotaxis GO:0060326 112 0.281
epithelial cell migration GO:0010631 119 0.280
negative regulation of canonical wnt signaling pathway GO:0090090 55 0.279
positive regulation of cell death GO:0010942 263 0.279
Worm
regulation of cellular component movement GO:0051270 334 0.275
negative regulation of epithelial cell proliferation GO:0050680 48 0.275
embryonic forelimb morphogenesis GO:0035115 4 0.273
heparan sulfate proteoglycan metabolic process GO:0030201 12 0.271
negative regulation of gliogenesis GO:0014014 3 0.267
myosin filament organization GO:0031033 2 0.267
cardiac chamber formation GO:0003207 2 0.267
protein import GO:0017038 130 0.267
cellular protein complex assembly GO:0043623 188 0.263
histone modification GO:0016570 251 0.263
salivary gland morphogenesis GO:0007435 4 0.259
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules GO:0016339 2 0.259
neural crest cell development GO:0014032 3 0.257
muscle cell proliferation GO:0033002 35 0.254
single organism cellular localization GO:1902580 332 0.252
positive regulation of intracellular protein transport GO:0090316 76 0.252
positive regulation of sulfur metabolic process GO:0051176 3 0.251
regulation of ossification GO:0030278 58 0.250
regulation of axon guidance GO:1902667 3 0.247
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.243
Human
positive regulation of protein transport GO:0051222 135 0.241
regulation of cell morphogenesis GO:0022604 153 0.240
proteoglycan biosynthetic process GO:0030166 20 0.239
negative regulation of cell proliferation GO:0008285 228 0.237
segmentation GO:0035282 4 0.236
negative regulation of interleukin 4 production GO:0032713 3 0.236
ossification GO:0001503 121 0.235
regulation of neuron projection development GO:0010975 57 0.235
gliogenesis GO:0042063 21 0.233
autonomic nervous system development GO:0048483 1 0.232
positive regulation of cell development GO:0010720 92 0.230
Mouse
negative regulation of apoptotic process GO:0043066 316 0.230
regulation of cell cycle process GO:0010564 266 0.229
Human
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.228
immune response GO:0006955 307 0.227
metencephalon development GO:0022037 2 0.224
regulation of axon extension involved in axon guidance GO:0048841 2 0.224
regulation of wnt signaling pathway GO:0030111 123 0.224
cardiac muscle cell contraction GO:0086003 4 0.224
growth GO:0040007 202 0.224
immune system development GO:0002520 195 0.223
Human
positive regulation of cell proliferation in bone marrow GO:0071864 1 0.220
cell projection organization GO:0030030 252 0.219
chromatin organization GO:0006325 351 0.219
head development GO:0060322 108 0.218
negative regulation of programmed cell death GO:0043069 321 0.218
single organism cell adhesion GO:0098602 179 0.216
regulation of heart induction GO:0090381 2 0.215
embryo development GO:0009790 123 0.215
Worm
negative regulation of catagen GO:0051796 1 0.213
regulation of cell differentiation GO:0045595 393 0.212
Mouse Fly
embryonic placenta development GO:0001892 1 0.211
positive regulation of cell differentiation GO:0045597 211 0.210
Mouse
vesicle mediated transport GO:0016192 371 0.209
regulation of protein binding GO:0043393 66 0.209
regulation of multi organism process GO:0043900 157 0.203
regulation of cellular response to growth factor stimulus GO:0090287 76 0.202
adherens junction organization GO:0034332 36 0.199
cell cell signaling GO:0007267 155 0.198
tissue migration GO:0090130 119 0.197
single organismal cell cell adhesion GO:0016337 148 0.195
pattern specification process GO:0007389 43 0.194
negative regulation of cell fate specification GO:0009996 3 0.192
cell adhesion GO:0007155 325 0.192
gland development GO:0048732 48 0.191
oligodendrocyte development GO:0014003 6 0.191
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 3 0.190
regulation of cell adhesion mediated by integrin GO:0033628 22 0.188
nephron epithelium development GO:0072009 23 0.188
embryonic epithelial tube formation GO:0001838 4 0.185
regulation of epithelial to mesenchymal transition GO:0010717 37 0.183
response to cytokine GO:0034097 232 0.182
response to biotic stimulus GO:0009607 276 0.181
embryonic eye morphogenesis GO:0048048 2 0.181
biological adhesion GO:0022610 331 0.181
negative regulation of cell death GO:0060548 345 0.179
regulation of protein transport GO:0051223 213 0.179
behavior GO:0007610 112 0.178
protein acetylation GO:0006473 116 0.178
negative regulation of type b pancreatic cell apoptotic process GO:2000675 3 0.176
striated muscle myosin thick filament assembly GO:0071688 2 0.175
photoreceptor cell differentiation GO:0046530 2 0.173
positive regulation of immune system process GO:0002684 283 0.171
Human
epithelial cell development GO:0002064 34 0.170
neurological system process GO:0050877 163 0.169
myoblast differentiation GO:0045445 21 0.167
embryonic hindlimb morphogenesis GO:0035116 2 0.165
muscle organ development GO:0007517 56 0.165
engulfment of apoptotic cell GO:0043652 2 0.164
internal protein amino acid acetylation GO:0006475 101 0.163
response to other organism GO:0051707 261 0.163
regulation of chemotaxis GO:0050920 74 0.163
regulation of nervous system development GO:0051960 88 0.161
Mouse
ventral spinal cord interneuron differentiation GO:0021514 1 0.161
oligodendrocyte differentiation GO:0048709 7 0.161
epithelium migration GO:0090132 119 0.161
regulation of nucleocytoplasmic transport GO:0046822 98 0.161
metanephric nephron morphogenesis GO:0072273 7 0.160
stem cell division GO:0017145 2 0.159
cell substrate adhesion GO:0031589 132 0.155
defense response GO:0006952 315 0.153
neuroepithelial cell differentiation GO:0060563 5 0.153
Fly
digestive tract morphogenesis GO:0048546 56 0.153
nucleocytoplasmic transport GO:0006913 176 0.151
response to acid chemical GO:0001101 66 0.151
epithelial tube branching involved in lung morphogenesis GO:0060441 4 0.151
neural tube formation GO:0001841 3 0.150
neuron projection development GO:0031175 106 0.149
positive regulation of neurogenesis GO:0050769 49 0.149
Mouse
regulation of cytokine production GO:0001817 232 0.148
organ formation GO:0048645 3 0.148
regulation of organ formation GO:0003156 4 0.146
central nervous system development GO:0007417 123 0.146
regulation of cellular ketone metabolic process GO:0010565 50 0.145
glial cell differentiation GO:0010001 11 0.145
heart induction GO:0003129 4 0.144
cell fate commitment involved in pattern specification GO:0060581 1 0.143
epithelial cell differentiation GO:0030855 141 0.143
Fly
cerebral cortex radial glia guided migration GO:0021801 1 0.142
embryonic skeletal joint morphogenesis GO:0060272 2 0.142
cellular ketone metabolic process GO:0042180 80 0.141
histone h3 acetylation GO:0043966 45 0.141
glycoprotein biosynthetic process GO:0009101 91 0.141
platelet activation GO:0030168 44 0.140
negative regulation of cellular protein metabolic process GO:0032269 353 0.140
mitotic cell cycle process GO:1903047 286 0.140
Human
forebrain development GO:0030900 26 0.139
positive regulation of cell morphogenesis involved in differentiation GO:0010770 50 0.139
regulation of intracellular transport GO:0032386 195 0.139
pallium development GO:0021543 10 0.139
sprouting angiogenesis GO:0002040 29 0.138
blood coagulation GO:0007596 76 0.138
epithelium development GO:0060429 227 0.137
Fly
response to external biotic stimulus GO:0043207 261 0.137
thymus development GO:0048538 3 0.136
mesenchyme development GO:0060485 59 0.135
mating GO:0007618 1 0.135
cytokine production GO:0001816 247 0.135
leukocyte activation GO:0045321 164 0.135
Human
regulation of heart morphogenesis GO:2000826 4 0.135
muscle cell differentiation GO:0042692 63 0.133
neuron development GO:0048666 113 0.132
Worm
striated muscle tissue development GO:0014706 59 0.132
regulation of secretion by cell GO:1903530 177 0.131
regulation of lymphocyte proliferation GO:0050670 64 0.131
Human
positive regulation of programmed cell death GO:0043068 249 0.131
Worm
cell substrate adherens junction assembly GO:0007045 30 0.129
trophectodermal cell differentiation GO:0001829 3 0.128
embryonic skeletal joint development GO:0072498 2 0.127
oogenesis GO:0048477 2 0.127
Fly
integrin activation GO:0033622 8 0.127
histone acetylation GO:0016573 93 0.127
regulation of dna binding GO:0051101 37 0.126
rna interference GO:0016246 4 0.126
cellular response to organic cyclic compound GO:0071407 127 0.126
covalent chromatin modification GO:0016569 254 0.125
adherens junction assembly GO:0034333 34 0.125
regulation of response to external stimulus GO:0032101 222 0.125
single organism reproductive process GO:0044702 98 0.124
Worm Fly
platelet formation GO:0030220 4 0.124
response to hormone GO:0009725 175 0.124
response to abiotic stimulus GO:0009628 336 0.123
positive regulation of heparan sulfate proteoglycan biosynthetic process GO:0010909 3 0.123
endocytosis GO:0006897 159 0.123
transmission of nerve impulse GO:0019226 11 0.122
cellular response to lipid GO:0071396 127 0.122
negative regulation of protein metabolic process GO:0051248 391 0.122
viral life cycle GO:0019058 132 0.122
negative regulation of developmental process GO:0051093 247 0.122
Fly
mesenchymal to epithelial transition GO:0060231 6 0.121
axonogenesis GO:0007409 31 0.121
neuron migration GO:0001764 11 0.121
myeloid cell differentiation GO:0030099 117 0.121
secretion by cell GO:0032940 226 0.121
regulation of striated muscle tissue development GO:0016202 26 0.119
peptide transport GO:0015833 74 0.119
morphogenesis of embryonic epithelium GO:0016331 4 0.118
homotypic cell cell adhesion GO:0034109 47 0.118
lymphocyte activation GO:0046649 133 0.117
Human
chromatin modification GO:0016568 298 0.117
keratinocyte migration GO:0051546 6 0.116
positive regulation of transport GO:0051050 336 0.115
regulation of epithelial cell differentiation involved in kidney development GO:2000696 4 0.115
negative regulation of cell development GO:0010721 48 0.115
negative regulation of apoptotic signaling pathway GO:2001234 97 0.115
positive regulation of epithelial cell proliferation GO:0050679 65 0.114
mitotic cell cycle GO:0000278 326 0.113
Human
lymphocyte proliferation GO:0046651 70 0.112
Human
sulfur compound biosynthetic process GO:0044272 38 0.111
negative regulation of neuron differentiation GO:0045665 21 0.111
positive regulation of cell adhesion GO:0045785 84 0.111
nuclear transport GO:0051169 179 0.111
internal peptidyl lysine acetylation GO:0018393 97 0.111
positive regulation of cellular component organization GO:0051130 376 0.111
cellular macromolecular complex assembly GO:0034622 324 0.110
Mouse
renal tubule development GO:0061326 19 0.110
Fly
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.110
Human
negative regulation of cellular component movement GO:0051271 106 0.108
regulation of leukocyte differentiation GO:1902105 61 0.108
metanephros development GO:0001656 16 0.108
lens morphogenesis in camera type eye GO:0002089 2 0.107
columnar cuboidal epithelial cell differentiation GO:0002065 14 0.107
Fly
regulation of binding GO:0051098 111 0.107
regulation of body fluid levels GO:0050878 99 0.107
response to lithium ion GO:0010226 2 0.107
regulation of behavior GO:0050795 82 0.106
organelle assembly GO:0070925 176 0.106
cardiac muscle cell action potential GO:0086001 23 0.106
regulation of glycoprotein biosynthetic process GO:0010559 14 0.106
diencephalon development GO:0021536 6 0.106
regulation of viral process GO:0050792 103 0.105
actin filament based process GO:0030029 224 0.105
negative regulation of binding GO:0051100 57 0.104
establishment of cell polarity GO:0030010 22 0.104
leukocyte cell cell adhesion GO:0007159 37 0.104
negative regulation of glial cell differentiation GO:0045686 1 0.104
regulation of muscle organ development GO:0048634 27 0.104
cell fate commitment GO:0045165 27 0.104
Human Worm Fly
establishment of blood brain barrier GO:0060856 1 0.104
somatic stem cell maintenance GO:0035019 4 0.104
Fly
protein localization to membrane GO:0072657 160 0.104
regulation of cell cell adhesion mediated by integrin GO:0033632 6 0.103
system process GO:0003008 349 0.103
positive regulation of stem cell differentiation GO:2000738 29 0.103
hindlimb morphogenesis GO:0035137 2 0.103
canonical wnt signaling pathway involved in regulation of cell proliferation GO:0044340 2 0.102
muscle tissue morphogenesis GO:0060415 19 0.102
sensory organ morphogenesis GO:0090596 21 0.101
positive regulation of protein binding GO:0032092 24 0.101
posttranscriptional regulation of gene expression GO:0010608 213 0.101
endocrine system development GO:0035270 26 0.099
embryonic camera type eye development GO:0031076 2 0.099
positive regulation of ossification GO:0045778 32 0.098
wound healing GO:0042060 115 0.097
humoral immune response GO:0006959 49 0.096
nitrogen compound transport GO:0071705 191 0.096
regulation of mononuclear cell proliferation GO:0032944 65 0.096
Human
renal system development GO:0072001 63 0.095
Fly
anatomical structure homeostasis GO:0060249 100 0.095
positive regulation of glycoprotein biosynthetic process GO:0010560 6 0.094
regulation of cell proliferation involved in heart morphogenesis GO:2000136 1 0.094
hemopoiesis GO:0030097 180 0.094
Human
regulation of cell growth GO:0001558 135 0.093
muscle cell development GO:0055001 29 0.092
amine metabolic process GO:0009308 44 0.092
regulation of mesenchymal cell proliferation GO:0010464 5 0.092
negative regulation of locomotion GO:0040013 118 0.091
negative regulation of neurogenesis GO:0050768 26 0.091
glycoprotein metabolic process GO:0009100 110 0.091
protein import into nucleus GO:0006606 104 0.091
single organism membrane organization GO:0044802 268 0.091
striated muscle cell differentiation GO:0051146 43 0.090
regulation of cellular amine metabolic process GO:0033238 11 0.090
regulation of smooth muscle cell proliferation GO:0048660 28 0.090
regulation of cytoplasmic transport GO:1903649 149 0.090
negative regulation of embryonic development GO:0045992 4 0.089
regulation of stem cell differentiation GO:2000736 56 0.089
regulation of mitotic cell cycle GO:0007346 189 0.088
Human
mapk cascade GO:0000165 288 0.088
negative regulation of cell cycle GO:0045786 193 0.088
multi organism cellular process GO:0044764 156 0.087
cell cell junction organization GO:0045216 69 0.087
myoblast fusion GO:0007520 1 0.086
regulation of myelination GO:0031641 1 0.086
integrin mediated signaling pathway GO:0007229 32 0.085
negative regulation of cellular component organization GO:0051129 235 0.085
regulation of endopeptidase activity GO:0052548 170 0.085
regulation of excretion GO:0044062 1 0.084
regulation of lymphocyte activation GO:0051249 103 0.084
Human
keratinization GO:0031424 2 0.082
regulation of intracellular protein transport GO:0033157 123 0.082
peptidyl lysine acetylation GO:0018394 101 0.082
positive regulation of behavior GO:0048520 60 0.082
modification of morphology or physiology of other organism GO:0035821 43 0.082
reproductive process GO:0022414 106 0.082
Worm Fly
regulation of viral transcription GO:0046782 34 0.081
protein catabolic process GO:0030163 325 0.081
response to nitrogen compound GO:1901698 184 0.081
cellular response to hormone stimulus GO:0032870 125 0.081
positive regulation of epithelial to mesenchymal transition GO:0010718 22 0.080
positive regulation of phosphorylation GO:0042327 394 0.080
signal transduction by phosphorylation GO:0023014 297 0.080
leukocyte proliferation GO:0070661 74 0.079
Human
positive regulation of intracellular transport GO:0032388 104 0.079
regulation of protein import into nucleus GO:0042306 78 0.079
carbohydrate derivative biosynthetic process GO:1901137 207 0.079
cellular component assembly involved in morphogenesis GO:0010927 73 0.079
response to metal ion GO:0010038 84 0.079
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.078
cell substrate junction assembly GO:0007044 35 0.078
amide biosynthetic process GO:0043604 15 0.078
protein targeting GO:0006605 187 0.077
positive regulation of neuron differentiation GO:0045666 40 0.077
Mouse
epithelial to mesenchymal transition GO:0001837 48 0.077
mononuclear cell proliferation GO:0032943 71 0.077
Human
cell proliferation in bone marrow GO:0071838 1 0.077
tissue homeostasis GO:0001894 63 0.077
negative regulation of cell migration GO:0030336 102 0.075
neuron projection morphogenesis GO:0048812 50 0.075
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.075
positive regulation of nervous system development GO:0051962 54 0.075
Mouse
cytoplasmic transport GO:0016482 379 0.074
cell differentiation involved in kidney development GO:0061005 9 0.074
myeloid leukocyte differentiation GO:0002573 60 0.074
protein processing GO:0016485 226 0.074
histone h4 acetylation GO:0043967 47 0.074
establishment of protein localization to organelle GO:0072594 172 0.073
regulation of neural precursor cell proliferation GO:2000177 4 0.073
negative regulation of endopeptidase activity GO:0010951 84 0.072
negative regulation of heart induction by canonical wnt signaling pathway GO:0003136 1 0.072
secondary metabolite biosynthetic process GO:0044550 2 0.072
bone mineralization GO:0030282 34 0.072
dephosphorylation GO:0016311 209 0.072
hormone secretion GO:0046879 65 0.072
cell projection morphogenesis GO:0048858 129 0.072
cellular lipid metabolic process GO:0044255 303 0.071
negative regulation of immune system process GO:0002683 136 0.071
positive regulation of neuroblast proliferation GO:0002052 2 0.071
negative regulation of cell motility GO:2000146 104 0.071
inner ear morphogenesis GO:0042472 4 0.071
positive regulation of cytoplasmic transport GO:1903651 82 0.070
catenin import into nucleus GO:0035411 18 0.069
cranial nerve development GO:0021545 4 0.069
odontogenesis GO:0042476 25 0.069
cellular response to abiotic stimulus GO:0071214 117 0.069
lung epithelial cell differentiation GO:0060487 1 0.069
protein acylation GO:0043543 138 0.068
substrate adhesion dependent cell spreading GO:0034446 41 0.068
regulation of hormone levels GO:0010817 125 0.068
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.068
regulation of myeloid leukocyte differentiation GO:0002761 39 0.068
cellular amino acid metabolic process GO:0006520 116 0.068
hormone transport GO:0009914 68 0.068
cardiac cell fate specification GO:0060912 1 0.067
regulation of glial cell differentiation GO:0045685 3 0.067
cardioblast cell fate specification GO:0042685 1 0.067
positive regulation of endothelial cell differentiation GO:0045603 2 0.067
immune effector process GO:0002252 159 0.066
cardiac muscle cell action potential involved in contraction GO:0086002 21 0.066
retinal ganglion cell axon guidance GO:0031290 2 0.066
specification of axis polarity GO:0065001 1 0.065
negative regulation of cell adhesion GO:0007162 64 0.064
notch signaling pathway GO:0007219 31 0.064
ectoderm development GO:0007398 3 0.063
bmp signaling pathway GO:0030509 49 0.063
regulation of immune response GO:0050776 201 0.063
positive regulation of insulin like growth factor receptor signaling pathway GO:0043568 4 0.063

TCF4 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.134
cancer DOID:162 167 0.132
organ system cancer DOID:0050686 164 0.089