Homo sapiens

257 known processes

TERF1

telomeric repeat binding factor (NIMA-interacting) 1

(Aliases: FLJ41416,TRBF1,TRF,TRF1,t-TRF1,hTRF1-AS,PIN2)

TERF1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
telomere maintenance via telomere lengthening GO:0010833 9 1.000
regulation of telomere maintenance via telomerase GO:0032210 6 1.000
protein localization to chromosome telomeric region GO:0070198 6 1.000
Human
regulation of telomere maintenance GO:0032204 13 0.999
positive regulation of telomere maintenance GO:0032206 4 0.999
rna dependent dna replication GO:0006278 16 0.996
anatomical structure homeostasis GO:0060249 100 0.994
positive regulation of cellular component organization GO:0051130 376 0.976
regulation of dna metabolic process GO:0051052 153 0.956
dna replication GO:0006260 116 0.948
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.909
telomere organization GO:0032200 33 0.884
glycoprotein biosynthetic process GO:0009101 91 0.874
positive regulation of dna replication GO:0045740 35 0.863
telomere maintenance GO:0000723 32 0.856
glycoprotein metabolic process GO:0009100 110 0.844
meiotic chromosome segregation GO:0045132 4 0.818
macromolecule glycosylation GO:0043413 63 0.757
wnt signaling pathway GO:0016055 156 0.741
positive regulation of dna metabolic process GO:0051054 73 0.725
regulation of cellular component biogenesis GO:0044087 281 0.709
negative regulation of dna replication GO:0008156 29 0.702
positive regulation of chromosome organization GO:2001252 41 0.692
protein auto adp ribosylation GO:0070213 4 0.686
carbohydrate derivative biosynthetic process GO:1901137 207 0.685
cellular macromolecular complex assembly GO:0034622 324 0.651
positive regulation of homeostatic process GO:0032846 47 0.651
telomere maintenance via telomerase GO:0007004 8 0.649
single organism carbohydrate metabolic process GO:0044723 193 0.633
positive regulation of wnt signaling pathway GO:0030177 54 0.616
carbohydrate metabolic process GO:0005975 207 0.595
regulation of canonical wnt signaling pathway GO:0060828 88 0.592
protein glycosylation GO:0006486 62 0.562
protein localization to chromosome GO:0034502 30 0.545
Human
sister chromatid segregation GO:0000819 54 0.542
mitotic sister chromatid segregation GO:0000070 53 0.482
protein adp ribosylation GO:0006471 9 0.480
protein localization to organelle GO:0033365 280 0.453
Human
negative regulation of cellular component organization GO:0051129 235 0.448
mitotic cell cycle GO:0000278 326 0.435
negative regulation of programmed cell death GO:0043069 321 0.426
positive regulation of cellular component biogenesis GO:0044089 158 0.409
peptidyl serine modification GO:0018209 106 0.405
cellular protein complex assembly GO:0043623 188 0.394
negative regulation of telomere maintenance GO:0032205 9 0.389
negative regulation of dna metabolic process GO:0051053 57 0.389
negative regulation of developmental process GO:0051093 247 0.386
protein polymerization GO:0051258 71 0.381
regulation of dna replication GO:0006275 68 0.376
microtubule polymerization or depolymerization GO:0031109 37 0.373
mitotic cell cycle process GO:1903047 286 0.359
organelle fission GO:0048285 149 0.313
negative regulation of binding GO:0051100 57 0.277
mitotic nuclear division GO:0007067 119 0.276
protein polyubiquitination GO:0000209 110 0.253
modification dependent macromolecule catabolic process GO:0043632 212 0.240
mitotic cell cycle phase transition GO:0044772 162 0.237
peptidyl serine phosphorylation GO:0018105 101 0.234
positive regulation of organelle organization GO:0010638 195 0.228
regulation of chromosome organization GO:0033044 103 0.225
peptidyl threonine phosphorylation GO:0018107 41 0.222
peptidyl threonine modification GO:0018210 45 0.215
canonical wnt signaling pathway GO:0060070 116 0.215
microtubule polymerization GO:0046785 18 0.203
negative regulation of cell proliferation GO:0008285 228 0.187
cell cycle phase transition GO:0044770 173 0.183
negative regulation of protein metabolic process GO:0051248 391 0.172
ubiquitin dependent protein catabolic process GO:0006511 206 0.171
chromosome segregation GO:0007059 114 0.169
organic hydroxy compound metabolic process GO:1901615 147 0.162
negative regulation of telomere maintenance via telomerase GO:0032211 5 0.161
cell cycle g2 m phase transition GO:0044839 43 0.161
cellular response to dna damage stimulus GO:0006974 379 0.160
Human
metaphase anaphase transition of cell cycle GO:0044784 21 0.154
regulation of microtubule based process GO:0032886 74 0.154
g2 m transition of mitotic cell cycle GO:0000086 41 0.148
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.144
modification dependent protein catabolic process GO:0019941 209 0.143
meiosis i GO:0007127 4 0.143
negative regulation of multicellular organismal process GO:0051241 317 0.143
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.137
negative regulation of epithelial cell proliferation GO:0050680 48 0.134
protein poly adp ribosylation GO:0070212 3 0.128
regulation of cell cycle phase transition GO:1901987 126 0.128
positive regulation of protein binding GO:0032092 24 0.125
organelle localization GO:0051640 84 0.121
positive regulation of protein complex assembly GO:0031334 86 0.115
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.114
regulation of protein binding GO:0043393 66 0.111
response to abiotic stimulus GO:0009628 336 0.111
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.110
regulation of cell cycle GO:0051726 393 0.109
negative regulation of cell death GO:0060548 345 0.107
negative regulation of cell cycle process GO:0010948 121 0.103
chromatin organization GO:0006325 351 0.098
regulation of transferase activity GO:0051338 355 0.095
regulation of epithelial cell proliferation GO:0050678 113 0.095
glycosylation GO:0070085 71 0.087
neuromuscular junction development GO:0007528 3 0.086
cellular macromolecule catabolic process GO:0044265 380 0.086
regulation of protein complex assembly GO:0043254 147 0.085
protein homooligomerization GO:0051260 100 0.083
dna packaging GO:0006323 77 0.082
post embryonic development GO:0009791 2 0.081
segmentation GO:0035282 4 0.081
apoptotic signaling pathway GO:0097190 268 0.081
regulation of wnt signaling pathway GO:0030111 123 0.078
locomotory behavior GO:0007626 1 0.077
epithelial cell proliferation GO:0050673 128 0.073
oocyte development GO:0048599 1 0.071
negative regulation of organelle organization GO:0010639 126 0.070
oocyte differentiation GO:0009994 2 0.070
dna conformation change GO:0071103 113 0.069
negative regulation of apoptotic process GO:0043066 316 0.064
regulation of binding GO:0051098 111 0.064
telomere capping GO:0016233 5 0.064
Human
regulation of proteasomal protein catabolic process GO:0061136 87 0.063
determination of adult lifespan GO:0008340 2 0.063
positive regulation of protein polymerization GO:0032273 45 0.063
photoreceptor cell maintenance GO:0045494 13 0.062
regulation of mitotic sister chromatid segregation GO:0033047 27 0.061
dna integrity checkpoint GO:0031570 71 0.060
cellular ketone metabolic process GO:0042180 80 0.060
regulation of kinase activity GO:0043549 314 0.057
lipid metabolic process GO:0006629 381 0.055
multicellular organismal aging GO:0010259 3 0.053
regulation of homeostatic process GO:0032844 121 0.053
protein dna complex assembly GO:0065004 64 0.052
protein catabolic process GO:0030163 325 0.052
growth GO:0040007 202 0.052
negative regulation of cell cycle phase transition GO:1901988 89 0.052
positive regulation of cell death GO:0010942 263 0.051
regulation of glycoprotein metabolic process GO:1903018 19 0.051
cell aging GO:0007569 52 0.050
negative regulation of protein catabolic process GO:0042177 59 0.050
negative regulation of chromosome organization GO:2001251 48 0.050
negative regulation of cell cycle GO:0045786 193 0.048
membrane organization GO:0061024 292 0.048
negative regulation of mitotic cell cycle GO:0045930 102 0.048
negative regulation of cellular protein metabolic process GO:0032269 353 0.047
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.046
cellular amine metabolic process GO:0044106 41 0.046
protein modification by small protein conjugation GO:0032446 342 0.046
cellular response to lipid GO:0071396 127 0.044
reciprocal meiotic recombination GO:0007131 4 0.044
regulation of growth GO:0040008 165 0.044
single organism cellular localization GO:1902580 332 0.044
negative regulation of dna binding GO:0043392 18 0.043
nuclear division GO:0000280 128 0.043
somitogenesis GO:0001756 2 0.042
dna double strand break processing GO:0000729 10 0.042
receptor mediated endocytosis GO:0006898 84 0.040
head development GO:0060322 108 0.040
positive regulation of cell differentiation GO:0045597 211 0.039
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.039
cellular protein catabolic process GO:0044257 261 0.039
regulation of protein ubiquitination GO:0031396 95 0.039
oogenesis GO:0048477 2 0.039
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.039
regulation of protein processing GO:0070613 150 0.037
negative regulation of actin nucleation GO:0051126 3 0.037
response to radiation GO:0009314 151 0.037
response to oxygen containing compound GO:1901700 369 0.036
intrinsic apoptotic signaling pathway GO:0097193 127 0.035
aging GO:0007568 66 0.035
negative regulation of cellular protein catabolic process GO:1903363 38 0.035
actin cytoskeleton organization GO:0030036 207 0.035
negative regulation of phosphate metabolic process GO:0045936 267 0.035
negative regulation of immune system process GO:0002683 136 0.034
negative regulation of cytoskeleton organization GO:0051494 45 0.033
endocytosis GO:0006897 159 0.033
cell type specific apoptotic process GO:0097285 125 0.033
reciprocal dna recombination GO:0035825 4 0.033
regulation of cell differentiation GO:0045595 393 0.033
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.032
female gamete generation GO:0007292 2 0.032
negative regulation of catabolic process GO:0009895 104 0.032
regulation of chromosome segregation GO:0051983 44 0.031
stem cell differentiation GO:0048863 93 0.031
cellular carbohydrate metabolic process GO:0044262 84 0.030
positive regulation of programmed cell death GO:0043068 249 0.030
negative regulation of cell differentiation GO:0045596 171 0.030
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.029
negative regulation of homeostatic process GO:0032845 59 0.029
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.028
glycerophospholipid metabolic process GO:0006650 84 0.028
glycerolipid biosynthetic process GO:0045017 51 0.028
dna catabolic process GO:0006308 49 0.028
regulation of locomotion GO:0040012 329 0.028
regulation of cellular component movement GO:0051270 334 0.028
negative regulation of cellular catabolic process GO:0031330 83 0.028
cellular lipid metabolic process GO:0044255 303 0.028
negative regulation of protein complex assembly GO:0031333 43 0.028
protein processing GO:0016485 226 0.027
lipid biosynthetic process GO:0008610 177 0.027
regulation of anatomical structure morphogenesis GO:0022603 286 0.027
cellular response to ionizing radiation GO:0071479 32 0.027
positive regulation of telomere maintenance via telomerase GO:0032212 2 0.027
phospholipid metabolic process GO:0006644 99 0.026
regulation of response to dna damage stimulus GO:2001020 94 0.026
negative regulation of protein polymerization GO:0032272 16 0.026
embryo development GO:0009790 123 0.025
proteasomal protein catabolic process GO:0010498 176 0.025
purine containing compound catabolic process GO:0072523 411 0.025
associative learning GO:0008306 1 0.024
protein localization to membrane GO:0072657 160 0.024
positive regulation of cell cycle GO:0045787 140 0.024
negative regulation of cell migration GO:0030336 102 0.024
negative regulation of apoptotic signaling pathway GO:2001234 97 0.024
plasma membrane organization GO:0007009 115 0.024
leukocyte differentiation GO:0002521 98 0.023
regulation of lymphocyte proliferation GO:0050670 64 0.023
regulation of carbohydrate metabolic process GO:0006109 54 0.023
cellular response to abiotic stimulus GO:0071214 117 0.023
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.023
protein ubiquitination GO:0016567 314 0.023
glycerolipid metabolic process GO:0046486 107 0.023
brain development GO:0007420 97 0.022
dna damage checkpoint GO:0000077 68 0.022
cellular amino acid metabolic process GO:0006520 116 0.022
intracellular protein transport GO:0006886 270 0.022
response to organic cyclic compound GO:0014070 204 0.022
regulation of cell cycle process GO:0010564 266 0.022
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.021
positive regulation of cytoskeleton organization GO:0051495 83 0.021
dna damage induced protein phosphorylation GO:0006975 5 0.021
protein maturation GO:0051604 233 0.021
negative regulation of cellular component movement GO:0051271 106 0.021
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 3 0.021
organophosphate biosynthetic process GO:0090407 163 0.020
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.020
immune effector process GO:0002252 159 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.020
regulation of mitotic cell cycle GO:0007346 189 0.020
cytokinesis GO:0000910 96 0.020
regulation of developmental growth GO:0048638 30 0.020
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.020
response to fungus GO:0009620 4 0.020
regulation of cellular response to stress GO:0080135 244 0.020
negative regulation of glycoprotein metabolic process GO:1903019 8 0.019
protein dna complex subunit organization GO:0071824 80 0.019
positive regulation of cell cycle process GO:0090068 106 0.019
regulation of dna endoreduplication GO:0032875 5 0.019
response to lipid GO:0033993 206 0.019
positive regulation of cellular amine metabolic process GO:0033240 7 0.018
double strand break repair GO:0006302 101 0.018
mapk cascade GO:0000165 288 0.018
regulation of protein maturation GO:1903317 150 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
cell fate determination GO:0001709 3 0.018
microtubule based process GO:0007017 210 0.017
mrna catabolic process GO:0006402 56 0.017
covalent chromatin modification GO:0016569 254 0.017
compound eye development GO:0048749 1 0.017
organelle assembly GO:0070925 176 0.017
neurological system process GO:0050877 163 0.017
negative regulation of protein modification process GO:0031400 200 0.017
response to nitrogen compound GO:1901698 184 0.017
proteasome assembly GO:0043248 7 0.016
negative regulation of cell development GO:0010721 48 0.016
regulation of dna binding GO:0051101 37 0.016
positive regulation of cell development GO:0010720 92 0.016
positive regulation of binding GO:0051099 45 0.016
positive regulation of protein phosphorylation GO:0001934 313 0.016
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.016
negative regulation of cell motility GO:2000146 104 0.016
regulation of neural precursor cell proliferation GO:2000177 4 0.016
negative regulation of protein maturation GO:1903318 142 0.016
central nervous system development GO:0007417 123 0.016
ossification GO:0001503 121 0.016
positive regulation of cell projection organization GO:0031346 64 0.016
mitotic sister chromatid separation GO:0051306 18 0.016
cell division GO:0051301 168 0.016
hematopoietic or lymphoid organ development GO:0048534 186 0.016
nucleosome assembly GO:0006334 50 0.016
cell cycle checkpoint GO:0000075 117 0.016
angiogenesis GO:0001525 147 0.015
secretion GO:0046903 254 0.015
regulation of microtubule polymerization GO:0031113 12 0.015
regulation of phagocytosis engulfment GO:0060099 2 0.015
positive regulation of cellular catabolic process GO:0031331 284 0.015
regulation of cellular amine metabolic process GO:0033238 11 0.015
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
neuron death GO:0070997 65 0.015
regulation of cellular amino acid metabolic process GO:0006521 6 0.015
regulation of protein kinase activity GO:0045859 289 0.015
vesicle mediated transport GO:0016192 371 0.015
recombinational repair GO:0000725 50 0.014
positive regulation of developmental process GO:0051094 314 0.014
negative regulation of growth GO:0045926 97 0.014
positive regulation of apoptotic process GO:0043065 246 0.014
regulation of establishment of protein localization GO:0070201 242 0.014
positive regulation of phosphorylation GO:0042327 394 0.014
nucleocytoplasmic transport GO:0006913 176 0.014
nucleotide catabolic process GO:0009166 408 0.014
negative regulation of locomotion GO:0040013 118 0.014
regulation of mitotic cell cycle phase transition GO:1901990 118 0.014
immune system development GO:0002520 195 0.014
actin filament based process GO:0030029 224 0.014
adult locomotory behavior GO:0008344 1 0.013
oxidation reduction process GO:0055114 396 0.013
positive regulation of transport GO:0051050 336 0.013
cellular response to external stimulus GO:0071496 111 0.013
regulation of nervous system development GO:0051960 88 0.013
cell morphogenesis GO:0000902 296 0.013
response to external biotic stimulus GO:0043207 261 0.013
developmental growth GO:0048589 48 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.013
regulation of cellular protein catabolic process GO:1903362 96 0.013
negative regulation of glycoprotein biosynthetic process GO:0010561 5 0.013
gtp metabolic process GO:0046039 239 0.013
innate immune response GO:0045087 178 0.013
engulfment of apoptotic cell GO:0043652 2 0.013
centrosome organization GO:0051297 58 0.013
regulation of cytoplasmic transport GO:1903649 149 0.012
ribosomal protein import into nucleus GO:0006610 2 0.012
positive regulation of neurogenesis GO:0050769 49 0.012
negative regulation of phosphorus metabolic process GO:0010563 267 0.012
cellular component disassembly GO:0022411 92 0.012
regulation of cell migration GO:0030334 289 0.012
purine nucleoside triphosphate metabolic process GO:0009144 412 0.012
developmental growth involved in morphogenesis GO:0060560 23 0.012
negative regulation of carbohydrate metabolic process GO:0045912 20 0.012
regulation of cell motility GO:2000145 299 0.012
response to caffeine GO:0031000 3 0.012
i kappab kinase nf kappab signaling GO:0007249 166 0.012
regulation of gene expression epigenetic GO:0040029 73 0.012
rna catabolic process GO:0006401 71 0.012
ameboidal type cell migration GO:0001667 135 0.012
response to gamma radiation GO:0010332 14 0.012
meiotic cell cycle process GO:1903046 8 0.012
negative regulation of b cell activation GO:0050869 6 0.011
osteoblast differentiation GO:0001649 92 0.011
nervous system development GO:0007399 293 0.011
protein autophosphorylation GO:0046777 123 0.011
negative regulation of protein processing GO:0010955 142 0.011
tissue homeostasis GO:0001894 63 0.011
signal transduction by phosphorylation GO:0023014 297 0.011
cellular response to radiation GO:0071478 65 0.011
fatty acid derivative metabolic process GO:1901568 35 0.011
reproductive structure development GO:0048608 55 0.011
epithelium migration GO:0090132 119 0.011
cell cycle arrest GO:0007050 71 0.011
protein targeting to nucleus GO:0044744 104 0.011
regulation of epithelial cell migration GO:0010632 93 0.011
circadian sleep wake cycle sleep GO:0050802 2 0.011
autophagy GO:0006914 88 0.011
macromolecular complex disassembly GO:0032984 60 0.011
ribonucleotide catabolic process GO:0009261 405 0.011
purine ribonucleoside metabolic process GO:0046128 437 0.011
positive regulation of cell proliferation GO:0008284 301 0.011
signal transduction involved in dna damage checkpoint GO:0072422 15 0.011
regulation of proteolysis GO:0030162 293 0.010
circadian behavior GO:0048512 2 0.010
glycerophospholipid biosynthetic process GO:0046474 40 0.010
hemopoiesis GO:0030097 180 0.010
system process GO:0003008 349 0.010
regulation of mitotic sister chromatid separation GO:0010965 27 0.010
neurogenesis GO:0022008 169 0.010
establishment of protein localization to plasma membrane GO:0090002 68 0.010
sensory perception GO:0007600 103 0.010
cell growth GO:0016049 160 0.010
microtubule cytoskeleton organization GO:0000226 176 0.010
regulation of peptidyl serine phosphorylation GO:0033135 50 0.010

TERF1 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.088
disease of cellular proliferation DOID:14566 174 0.088
organ system cancer DOID:0050686 164 0.027
central nervous system disease DOID:331 186 0.014
nervous system disease DOID:863 431 0.014