|
|
positive regulation of pathway restricted smad protein phosphorylation
|
GO:0010862 |
22 |
1.000
|
|
|
|
positive regulation of cardioblast differentiation
|
GO:0051891 |
2 |
0.991
|
|
|
|
regulation of pathway restricted smad protein phosphorylation
|
GO:0060393 |
34 |
0.988
|
|
|
|
positive regulation of odontogenesis
|
GO:0042482 |
3 |
0.987
|
|
|
|
smad protein complex assembly
|
GO:0007183 |
12 |
0.986
|
|
|
|
regulation of activin receptor signaling pathway
|
GO:0032925 |
14 |
0.967
|
Human |
|
|
regulation of transforming growth factor beta receptor signaling pathway
|
GO:0017015 |
48 |
0.961
|
|
|
|
endocardial cushion development
|
GO:0003197 |
3 |
0.955
|
Human |
|
|
activin receptor signaling pathway
|
GO:0032924 |
24 |
0.955
|
Human Fly |
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.953
|
|
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.950
|
|
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.941
|
|
|
|
pathway restricted smad protein phosphorylation
|
GO:0060389 |
38 |
0.940
|
|
|
|
regulation of smad protein import into nucleus
|
GO:0060390 |
10 |
0.938
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.923
|
|
|
|
negative regulation of trophoblast cell migration
|
GO:1901164 |
3 |
0.915
|
Human |
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.901
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.882
|
|
|
|
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090101 |
45 |
0.857
|
Human |
|
|
regulation of branching involved in ureteric bud morphogenesis
|
GO:0090189 |
3 |
0.805
|
|
|
|
negative regulation of calcium ion transport into cytosol
|
GO:0010523 |
3 |
0.801
|
|
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.797
|
|
|
|
response to growth factor
|
GO:0070848 |
205 |
0.759
|
|
|
|
chorionic trophoblast cell proliferation
|
GO:0097360 |
2 |
0.754
|
Human |
|
|
negative regulation of chondrocyte proliferation
|
GO:1902731 |
1 |
0.751
|
Human |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.750
|
|
|
|
atrial septum primum morphogenesis
|
GO:0003289 |
1 |
0.742
|
Human |
|
|
cardiac muscle tissue development
|
GO:0048738 |
39 |
0.725
|
Human |
|
|
regulation of protein import into nucleus
|
GO:0042306 |
78 |
0.703
|
|
|
|
positive regulation of cytoplasmic transport
|
GO:1903651 |
82 |
0.702
|
|
|
|
cardiac muscle cell fate commitment
|
GO:0060923 |
4 |
0.682
|
Human |
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.675
|
|
|
|
cation transmembrane transport
|
GO:0098655 |
238 |
0.657
|
|
|
|
negative regulation of transforming growth factor beta receptor signaling pathway
|
GO:0030512 |
28 |
0.656
|
|
|
|
positive regulation of hair follicle maturation
|
GO:0048818 |
2 |
0.637
|
|
|
|
regulation of bmp signaling pathway
|
GO:0030510 |
27 |
0.622
|
Human Fly |
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.622
|
|
|
|
endocardial cell differentiation
|
GO:0060956 |
2 |
0.620
|
Human |
|
|
metal ion transport
|
GO:0030001 |
272 |
0.615
|
|
|
|
sequestering of metal ion
|
GO:0051238 |
24 |
0.606
|
|
|
|
negative regulation of pathway restricted smad protein phosphorylation
|
GO:0060394 |
11 |
0.597
|
|
|
|
cation transport
|
GO:0006812 |
331 |
0.592
|
|
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.590
|
|
|
|
atrioventricular valve development
|
GO:0003171 |
3 |
0.588
|
Human |
|
|
cytoplasmic transport
|
GO:0016482 |
379 |
0.588
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.583
|
|
|
|
negative regulation of epithelial cell migration
|
GO:0010633 |
38 |
0.579
|
Human |
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.578
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.574
|
Mouse Worm Fly |
|
|
inorganic ion transmembrane transport
|
GO:0098660 |
231 |
0.572
|
|
|
|
cellular response to endogenous stimulus
|
GO:0071495 |
336 |
0.566
|
|
|
|
mitral valve morphogenesis
|
GO:0003183 |
2 |
0.562
|
Human |
|
|
single organism nuclear import
|
GO:1902593 |
104 |
0.560
|
|
|
|
patterning of blood vessels
|
GO:0001569 |
2 |
0.559
|
|
|
|
positive regulation of trophoblast cell migration
|
GO:1901165 |
2 |
0.554
|
Human |
|
|
epithelial cell fate commitment
|
GO:0072148 |
3 |
0.553
|
Human |
|
|
positive regulation of smad protein import into nucleus
|
GO:0060391 |
8 |
0.547
|
|
|
|
transmembrane transport
|
GO:0055085 |
399 |
0.543
|
|
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.540
|
|
|
|
ion homeostasis
|
GO:0050801 |
230 |
0.538
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.537
|
Mouse |
|
|
atrial septum morphogenesis
|
GO:0060413 |
5 |
0.535
|
Human |
|
|
negative regulation of cellular response to growth factor stimulus
|
GO:0090288 |
41 |
0.522
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.520
|
|
|
|
retinal ganglion cell axon guidance
|
GO:0031290 |
2 |
0.518
|
|
|
|
inorganic cation transmembrane transport
|
GO:0098662 |
194 |
0.516
|
|
|
|
regulation of intracellular transport
|
GO:0032386 |
195 |
0.516
|
|
|
|
positive regulation of biomineral tissue development
|
GO:0070169 |
20 |
0.514
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.512
|
|
|
|
negative regulation of ion transmembrane transport
|
GO:0034766 |
26 |
0.510
|
|
|
|
tube development
|
GO:0035295 |
125 |
0.509
|
Human Rat |
|
|
chondrocyte development
|
GO:0002063 |
1 |
0.496
|
Human |
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.495
|
Human Mouse |
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.493
|
|
|
|
sequestering of calcium ion
|
GO:0051208 |
17 |
0.490
|
|
|
|
negative regulation of extrinsic apoptotic signaling pathway
|
GO:2001237 |
52 |
0.487
|
|
|
|
cardiac epithelial to mesenchymal transition
|
GO:0060317 |
3 |
0.485
|
|
|
|
bone mineralization
|
GO:0030282 |
34 |
0.480
|
Human |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.480
|
Worm |
|
|
cardiac atrium morphogenesis
|
GO:0003209 |
7 |
0.478
|
Human |
|
|
common partner smad protein phosphorylation
|
GO:0007182 |
3 |
0.474
|
|
|
|
negative regulation of ion transport
|
GO:0043271 |
39 |
0.470
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.467
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.462
|
|
|
|
response to host defenses
|
GO:0052200 |
2 |
0.460
|
|
|
|
negative regulation of release of sequestered calcium ion into cytosol
|
GO:0051280 |
1 |
0.455
|
|
|
|
negative regulation of cell growth
|
GO:0030308 |
83 |
0.454
|
Human |
|
|
regulation of cytoplasmic transport
|
GO:1903649 |
149 |
0.447
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.446
|
|
|
|
regulation of nucleocytoplasmic transport
|
GO:0046822 |
98 |
0.444
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.441
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.439
|
|
|
|
positive regulation of fibroblast migration
|
GO:0010763 |
3 |
0.434
|
|
|
|
tissue morphogenesis
|
GO:0048729 |
96 |
0.432
|
Human |
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.424
|
|
|
|
regulation of transporter activity
|
GO:0032409 |
82 |
0.424
|
|
|
|
positive regulation of protein import into nucleus
|
GO:0042307 |
46 |
0.423
|
|
|
|
system process
|
GO:0003008 |
349 |
0.419
|
Human |
|
|
epithelial to mesenchymal transition
|
GO:0001837 |
48 |
0.418
|
|
|
|
nucleocytoplasmic transport
|
GO:0006913 |
176 |
0.416
|
|
|
|
evasion or tolerance of host defenses
|
GO:0044415 |
2 |
0.415
|
|
|
|
cytosolic calcium ion homeostasis
|
GO:0051480 |
89 |
0.413
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.413
|
Fly |
|
|
protein targeting
|
GO:0006605 |
187 |
0.411
|
|
|
|
regulation of lung blood pressure
|
GO:0014916 |
1 |
0.411
|
Human |
|
|
negative regulation of macrophage cytokine production
|
GO:0010936 |
3 |
0.411
|
|
|
|
defense response to fungus
|
GO:0050832 |
4 |
0.407
|
Worm |
|
|
peptidyl serine modification
|
GO:0018209 |
106 |
0.406
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.403
|
|
|
|
circulatory system development
|
GO:0072359 |
262 |
0.401
|
Human Mouse |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.397
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.394
|
|
|
|
response to cholesterol
|
GO:0070723 |
11 |
0.393
|
|
|
|
biological adhesion
|
GO:0022610 |
331 |
0.392
|
Human Worm |
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.390
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.389
|
Human |
|
|
protein localization to organelle
|
GO:0033365 |
280 |
0.385
|
|
|
|
positive regulation of intracellular protein transport
|
GO:0090316 |
76 |
0.382
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.381
|
|
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.381
|
|
|
|
lens development in camera type eye
|
GO:0002088 |
2 |
0.380
|
Mouse |
|
|
endocardial cell fate commitment
|
GO:0060957 |
1 |
0.377
|
Human |
|
|
avoidance of defenses of other organism involved in symbiotic interaction
|
GO:0051832 |
2 |
0.377
|
|
|
|
calcium ion homeostasis
|
GO:0055074 |
122 |
0.372
|
|
|
|
digestive tract development
|
GO:0048565 |
75 |
0.370
|
Rat |
|
|
regulation of protein ubiquitination
|
GO:0031396 |
95 |
0.368
|
|
|
|
evasion or tolerance of host defenses by virus
|
GO:0019049 |
2 |
0.367
|
|
|
|
regulation of cellular amino acid metabolic process
|
GO:0006521 |
6 |
0.364
|
|
|
|
regulation of calcium ion transport
|
GO:0051924 |
79 |
0.361
|
|
|
|
negative regulation of homeostatic process
|
GO:0032845 |
59 |
0.360
|
|
|
|
protein targeting to nucleus
|
GO:0044744 |
104 |
0.360
|
|
|
|
regulation of sequestering of calcium ion
|
GO:0051282 |
41 |
0.359
|
|
|
|
cellular divalent inorganic cation homeostasis
|
GO:0072503 |
128 |
0.355
|
|
|
|
regulation of multi organism process
|
GO:0043900 |
157 |
0.355
|
Human |
|
|
positive regulation of homeostatic process
|
GO:0032846 |
47 |
0.354
|
Human |
|
|
regulation of locomotion
|
GO:0040012 |
329 |
0.352
|
Human |
|
|
septum primum development
|
GO:0003284 |
1 |
0.352
|
Human |
|
|
endocardial cushion cell differentiation
|
GO:0061443 |
1 |
0.348
|
Human |
|
|
regulation of odontogenesis
|
GO:0042481 |
4 |
0.348
|
|
|
|
regulation of catagen
|
GO:0051794 |
3 |
0.334
|
|
|
|
calcium ion transport
|
GO:0006816 |
147 |
0.331
|
|
|
|
organ morphogenesis
|
GO:0009887 |
147 |
0.329
|
Human Mouse Fly |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.325
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.323
|
|
|
|
regulation of protein targeting
|
GO:1903533 |
91 |
0.322
|
|
|
|
cell junction organization
|
GO:0034330 |
79 |
0.320
|
Human |
|
|
positive regulation of intracellular transport
|
GO:0032388 |
104 |
0.318
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.316
|
|
|
|
regulation of ion homeostasis
|
GO:2000021 |
73 |
0.316
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.316
|
Human Mouse |
|
|
regulation of cell adhesion
|
GO:0030155 |
166 |
0.315
|
Human Worm |
|
|
multi organism cellular process
|
GO:0044764 |
156 |
0.314
|
|
|
|
mapk cascade
|
GO:0000165 |
288 |
0.314
|
|
|
|
peptidyl threonine phosphorylation
|
GO:0018107 |
41 |
0.313
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.311
|
Worm |
|
|
positive regulation of immunoglobulin mediated immune response
|
GO:0002891 |
4 |
0.308
|
|
|
|
negative regulation of sequestering of calcium ion
|
GO:0051283 |
41 |
0.308
|
|
|
|
regulation of transmembrane transporter activity
|
GO:0022898 |
74 |
0.306
|
|
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.305
|
|
|
|
bmp signaling pathway
|
GO:0030509 |
49 |
0.304
|
Human Fly |
|
|
response to sterol
|
GO:0036314 |
14 |
0.304
|
|
|
|
nuclear transport
|
GO:0051169 |
179 |
0.304
|
|
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.299
|
|
|
|
regulation of epithelial to mesenchymal transition
|
GO:0010717 |
37 |
0.299
|
|
|
|
positive regulation of nucleocytoplasmic transport
|
GO:0046824 |
54 |
0.297
|
|
|
|
regulation of protein localization to nucleus
|
GO:1900180 |
85 |
0.297
|
|
|
|
mesenchyme development
|
GO:0060485 |
59 |
0.296
|
|
|
|
cellular component morphogenesis
|
GO:0032989 |
314 |
0.296
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.294
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.293
|
Mouse |
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.289
|
|
|
|
regulation of calcium ion transport into cytosol
|
GO:0010522 |
33 |
0.288
|
|
|
|
divalent inorganic cation transport
|
GO:0072511 |
158 |
0.286
|
|
|
|
angiogenesis
|
GO:0001525 |
147 |
0.281
|
Human Mouse |
|
|
receptor catabolic process
|
GO:0032801 |
11 |
0.280
|
|
|
|
embryonic heart tube morphogenesis
|
GO:0003143 |
8 |
0.277
|
Human |
|
|
negative regulation of programmed cell death
|
GO:0043069 |
321 |
0.277
|
|
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.274
|
|
|
|
cellular ion homeostasis
|
GO:0006873 |
168 |
0.272
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.272
|
Human Worm |
|
|
glial cell migration
|
GO:0008347 |
4 |
0.270
|
|
|
|
regulation of epithelial cell migration
|
GO:0010632 |
93 |
0.268
|
Human |
|
|
endocardial cushion cell fate commitment
|
GO:0061445 |
1 |
0.268
|
Human |
|
|
endothelial cell migration
|
GO:0043542 |
86 |
0.268
|
Human Mouse |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.267
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.265
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.264
|
Worm |
|
|
positive regulation of mesonephros development
|
GO:0061213 |
2 |
0.261
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.261
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.258
|
Human |
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.258
|
|
|
|
heart development
|
GO:0007507 |
95 |
0.256
|
Human Mouse |
|
|
cell matrix adhesion
|
GO:0007160 |
85 |
0.255
|
Human |
|
|
negative regulation of bmp signaling pathway
|
GO:0030514 |
17 |
0.251
|
|
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.249
|
Human |
|
|
actin filament based process
|
GO:0030029 |
224 |
0.249
|
|
|
|
regulation of calcium ion transmembrane transporter activity
|
GO:1901019 |
28 |
0.246
|
|
|
|
blood circulation
|
GO:0008015 |
113 |
0.246
|
Human |
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.246
|
|
|
|
negative regulation of cell death
|
GO:0060548 |
345 |
0.244
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.244
|
|
|
|
cellular metal ion homeostasis
|
GO:0006875 |
146 |
0.244
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.243
|
Worm |
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.243
|
|
|
|
negative regulation of transporter activity
|
GO:0032410 |
25 |
0.242
|
|
|
|
response to host
|
GO:0075136 |
2 |
0.239
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.237
|
|
|
|
cellular calcium ion homeostasis
|
GO:0006874 |
117 |
0.237
|
|
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.232
|
|
|
|
blood vessel endothelial cell migration
|
GO:0043534 |
42 |
0.230
|
Human |
|
|
release of sequestered calcium ion into cytosol
|
GO:0051209 |
41 |
0.229
|
|
|
|
regulation of ion transport
|
GO:0043269 |
189 |
0.229
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.229
|
|
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.226
|
|
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.226
|
Human |
|
|
defense response
|
GO:0006952 |
315 |
0.226
|
Worm |
|
|
cellular chemical homeostasis
|
GO:0055082 |
180 |
0.223
|
|
|
|
mesenchymal cell development
|
GO:0014031 |
50 |
0.221
|
|
|
|
modulation by virus of host morphology or physiology
|
GO:0019048 |
10 |
0.220
|
|
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.220
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.217
|
|
|
|
negative regulation of transmembrane transport
|
GO:0034763 |
29 |
0.216
|
|
|
|
gastrulation
|
GO:0007369 |
51 |
0.215
|
|
|
|
negative regulation of alkaline phosphatase activity
|
GO:0010693 |
2 |
0.215
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.214
|
Mouse Fly |
|
|
wound healing
|
GO:0042060 |
115 |
0.213
|
Human |
|
|
cell development
|
GO:0048468 |
328 |
0.212
|
|
|
|
monovalent inorganic cation transport
|
GO:0015672 |
128 |
0.208
|
|
|
|
regulation of cardioblast differentiation
|
GO:0051890 |
4 |
0.207
|
|
|
|
reactive oxygen species metabolic process
|
GO:0072593 |
75 |
0.206
|
Human |
|
|
ameboidal type cell migration
|
GO:0001667 |
135 |
0.206
|
Human Mouse |
|
|
negative regulation of apoptotic signaling pathway
|
GO:2001234 |
97 |
0.206
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.204
|
Human Worm |
|
|
positive regulation of cellular amine metabolic process
|
GO:0033240 |
7 |
0.204
|
|
|
|
positive regulation of bmp signaling pathway
|
GO:0030513 |
9 |
0.203
|
Human Fly |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.203
|
|
|
|
positive regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014068 |
28 |
0.202
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.201
|
Fly |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.200
|
|
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.199
|
Worm |
|
|
myeloid dendritic cell differentiation
|
GO:0043011 |
3 |
0.199
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.198
|
Human |
|
|
negative regulation of cell differentiation
|
GO:0045596 |
171 |
0.198
|
Mouse Rat |
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.196
|
|
|
|
regulation of heart contraction
|
GO:0008016 |
50 |
0.194
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.193
|
|
|
|
positive regulation of cell migration
|
GO:0030335 |
172 |
0.193
|
Human |
|
|
striated muscle tissue development
|
GO:0014706 |
59 |
0.193
|
Human |
|
|
regulation of ossification
|
GO:0030278 |
58 |
0.192
|
Human |
|
|
calcium ion transport into cytosol
|
GO:0060402 |
48 |
0.189
|
|
|
|
regulation of release of sequestered calcium ion into cytosol
|
GO:0051279 |
27 |
0.185
|
|
|
|
carbohydrate derivative biosynthetic process
|
GO:1901137 |
207 |
0.185
|
|
|
|
peptidyl serine phosphorylation
|
GO:0018105 |
101 |
0.185
|
|
|
|
regulation of collagen metabolic process
|
GO:0010712 |
15 |
0.184
|
|
|
|
positive regulation of cellular component movement
|
GO:0051272 |
181 |
0.181
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.181
|
|
|
|
regulation of actin filament based process
|
GO:0032970 |
141 |
0.180
|
|
|
|
muscle structure development
|
GO:0061061 |
98 |
0.177
|
Human |
|
|
regulation of nucleotide metabolic process
|
GO:0006140 |
269 |
0.176
|
|
|
|
interspecies interaction between organisms
|
GO:0044419 |
156 |
0.176
|
|
|
|
salivary gland morphogenesis
|
GO:0007435 |
4 |
0.175
|
|
|
|
positive regulation of protein localization to nucleus
|
GO:1900182 |
48 |
0.175
|
|
|
|
modification dependent protein catabolic process
|
GO:0019941 |
209 |
0.175
|
|
|
|
epithelium development
|
GO:0060429 |
227 |
0.174
|
Human Rat |
|
|
myeloid dendritic cell activation
|
GO:0001773 |
4 |
0.174
|
|
|
|
positive regulation of epithelial cell migration
|
GO:0010634 |
55 |
0.173
|
Human |
|
|
regulation of transmembrane transport
|
GO:0034762 |
139 |
0.173
|
|
|
|
positive regulation of peptidase activity
|
GO:0010952 |
88 |
0.173
|
Human |
|
|
protein import into nucleus
|
GO:0006606 |
104 |
0.172
|
|
|
|
positive regulation of catagen
|
GO:0051795 |
2 |
0.172
|
|
|
|
sodium ion transport
|
GO:0006814 |
61 |
0.171
|
|
|
|
interaction with host
|
GO:0051701 |
42 |
0.170
|
|
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.167
|
|
|
|
cytosolic calcium ion transport
|
GO:0060401 |
48 |
0.166
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.165
|
Human |
|
|
regulation of blood circulation
|
GO:1903522 |
59 |
0.164
|
|
|
|
divalent metal ion transport
|
GO:0070838 |
152 |
0.164
|
|
|
|
regulation of cation channel activity
|
GO:2001257 |
33 |
0.162
|
|
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.162
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.161
|
Human |
|
|
regulation of cell morphogenesis involved in differentiation
|
GO:0010769 |
83 |
0.161
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.160
|
|
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.159
|
|
|
|
protein localization to nucleus
|
GO:0034504 |
136 |
0.158
|
|
|
|
cell junction assembly
|
GO:0034329 |
67 |
0.158
|
Human |
|
|
epithelial tube morphogenesis
|
GO:0060562 |
38 |
0.155
|
Human |
|
|
regulation of ion transmembrane transporter activity
|
GO:0032412 |
72 |
0.155
|
|
|
|
neuron projection development
|
GO:0031175 |
106 |
0.155
|
Fly |
|
|
regulation of cell growth
|
GO:0001558 |
135 |
0.152
|
|
|
|
cardiovascular system development
|
GO:0072358 |
262 |
0.152
|
Human Mouse |
|
|
viral process
|
GO:0016032 |
146 |
0.151
|
|
|
|
dorsal ventral pattern formation
|
GO:0009953 |
15 |
0.151
|
Human |
|
|
peptidyl threonine modification
|
GO:0018210 |
45 |
0.150
|
|
|
|
regulation of reactive oxygen species metabolic process
|
GO:2000377 |
41 |
0.149
|
Human |
|
|
positive regulation of isotype switching to iga isotypes
|
GO:0048298 |
2 |
0.148
|
|
|
|
negative regulation of phagocytosis
|
GO:0050765 |
4 |
0.148
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.145
|
|
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.144
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.144
|
|
|
|
positive regulation of determination of dorsal identity
|
GO:2000017 |
1 |
0.144
|
Human |
|
|
epithelial cell migration
|
GO:0010631 |
119 |
0.144
|
Human Mouse |
|
|
chemical homeostasis
|
GO:0048878 |
306 |
0.144
|
|
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.142
|
|
|
|
digestive system development
|
GO:0055123 |
75 |
0.142
|
Rat |
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.142
|
|
|
|
positive regulation of aldosterone metabolic process
|
GO:0032346 |
2 |
0.142
|
|
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.141
|
|
|
|
positive regulation of aldosterone biosynthetic process
|
GO:0032349 |
2 |
0.140
|
|
|
|
positive regulation of activin receptor signaling pathway
|
GO:0032927 |
6 |
0.140
|
Human |
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.139
|
|
|
|
extracellular structure organization
|
GO:0043062 |
41 |
0.139
|
Mouse |
|
|
response to wounding
|
GO:0009611 |
168 |
0.138
|
Human |
|
|
striated muscle cell differentiation
|
GO:0051146 |
43 |
0.137
|
Human |
|
|
negative regulation of growth
|
GO:0045926 |
97 |
0.136
|
Human |
|
|
muscle contraction
|
GO:0006936 |
73 |
0.136
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.135
|
|
|
|
nucleoside phosphate biosynthetic process
|
GO:1901293 |
109 |
0.135
|
|
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.134
|
|
|
|
endosomal transport
|
GO:0016197 |
129 |
0.133
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.133
|
Human |
|
|
regulation of neural precursor cell proliferation
|
GO:2000177 |
4 |
0.131
|
|
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.131
|
|
|
|
regulation of peptidyl serine phosphorylation
|
GO:0033135 |
50 |
0.130
|
|
|
|
ribose phosphate biosynthetic process
|
GO:0046390 |
82 |
0.130
|
|
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.129
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.129
|
Worm |
|
|
response to steroid hormone
|
GO:0048545 |
80 |
0.128
|
Rat |
|
|
cell morphogenesis involved in differentiation
|
GO:0000904 |
144 |
0.128
|
|
|
|
skeletal system development
|
GO:0001501 |
79 |
0.128
|
Human Mouse |
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.128
|
|
|
|
cell growth
|
GO:0016049 |
160 |
0.127
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.127
|
|
|
|
negative regulation of cell proliferation
|
GO:0008285 |
228 |
0.126
|
Human Mouse |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.125
|
|
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.124
|
|
|
|
appendage morphogenesis
|
GO:0035107 |
16 |
0.124
|
Human Fly |
|
|
positive regulation of branching involved in ureteric bud morphogenesis
|
GO:0090190 |
2 |
0.123
|
|
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.122
|
Human |
|
|
regulation of dephosphorylation
|
GO:0035303 |
96 |
0.121
|
|
|
|
segmentation
|
GO:0035282 |
4 |
0.121
|
|
|
|
negative regulation of ion transmembrane transporter activity
|
GO:0032413 |
19 |
0.120
|
|
|
|
growth
|
GO:0040007 |
202 |
0.119
|
|
|
|
blood vessel morphogenesis
|
GO:0048514 |
162 |
0.119
|
Human Mouse |
|
|
connective tissue development
|
GO:0061448 |
39 |
0.118
|
Human Mouse |
|
|
muscle tissue development
|
GO:0060537 |
62 |
0.118
|
Human |
|
|
mucopolysaccharide metabolic process
|
GO:1903510 |
27 |
0.117
|
|
|
|
positive regulation of epithelial to mesenchymal transition
|
GO:0010718 |
22 |
0.117
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.117
|
|
|
|
ketone biosynthetic process
|
GO:0042181 |
17 |
0.116
|
|
|
|
cardiac septum development
|
GO:0003279 |
13 |
0.115
|
Human |
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.115
|
|
|
|
response to caffeine
|
GO:0031000 |
3 |
0.115
|
|
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.114
|
|
|
|
mesonephric epithelium development
|
GO:0072163 |
14 |
0.114
|
|
|
|
regulation of stem cell differentiation
|
GO:2000736 |
56 |
0.114
|
|
|
|
negative regulation of phosphatase activity
|
GO:0010923 |
61 |
0.113
|
|
|
|
regulation of protein modification by small protein conjugation or removal
|
GO:1903320 |
107 |
0.112
|
|
|
|
negative regulation of epithelial cell proliferation
|
GO:0050680 |
48 |
0.112
|
Mouse |
|
|
regulation of cytoskeleton organization
|
GO:0051493 |
177 |
0.112
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.112
|
|
|
|
glycosaminoglycan catabolic process
|
GO:0006027 |
8 |
0.112
|
|
|
|
catagen
|
GO:0042637 |
3 |
0.112
|
|
|
|
single organism carbohydrate metabolic process
|
GO:0044723 |
193 |
0.111
|
|
|
|
nuclear import
|
GO:0051170 |
106 |
0.111
|
|
|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.111
|
|
|
|
lymphocyte proliferation
|
GO:0046651 |
70 |
0.111
|
|
|
|
branching morphogenesis of an epithelial tube
|
GO:0048754 |
19 |
0.110
|
|
|
|
cardiac chamber morphogenesis
|
GO:0003206 |
26 |
0.110
|
Human |
|
|
negative regulation of cytoplasmic transport
|
GO:1903650 |
46 |
0.110
|
|
|
|
negative regulation of skeletal muscle tissue development
|
GO:0048642 |
2 |
0.109
|
|
|
|
craniofacial suture morphogenesis
|
GO:0097094 |
3 |
0.108
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.108
|
|
|
|
positive regulation of endothelial cell migration
|
GO:0010595 |
39 |
0.108
|
Human |
|
|
regulation of alkaline phosphatase activity
|
GO:0010692 |
2 |
0.108
|
|
|
|
heart contraction
|
GO:0060047 |
62 |
0.108
|
|
|
|
regulation of osteoblast differentiation
|
GO:0045667 |
38 |
0.108
|
Human |
|
|
negative regulation of calcium ion transport
|
GO:0051926 |
19 |
0.107
|
|
|
|
regulation of biomineral tissue development
|
GO:0070167 |
31 |
0.107
|
Human |
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.106
|
Fly |
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.105
|
|
|
|
response to extracellular stimulus
|
GO:0009991 |
85 |
0.105
|
Human |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.104
|
|
|
|
positive regulation of cell growth
|
GO:0030307 |
48 |
0.103
|
|
|
|
activation of mapk activity
|
GO:0000187 |
45 |
0.103
|
|
|
|
ureteric bud development
|
GO:0001657 |
13 |
0.103
|
|
|
|
ion transmembrane transport
|
GO:0034220 |
338 |
0.103
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.102
|
|
|
|
morphogenesis of an epithelium
|
GO:0002009 |
60 |
0.101
|
Human |
|
|
interleukin 17 production
|
GO:0032620 |
12 |
0.101
|
|
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.101
|
|
|
|
appendage development
|
GO:0048736 |
23 |
0.101
|
Human Fly |
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.100
|
Human Fly |
|
|
trabecula morphogenesis
|
GO:0061383 |
2 |
0.100
|
|
|
|
hormone secretion
|
GO:0046879 |
65 |
0.100
|
|
|
|
positive regulation of stem cell differentiation
|
GO:2000738 |
29 |
0.100
|
|
|
|
regulation of endothelial cell migration
|
GO:0010594 |
67 |
0.100
|
Human |
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.099
|
|
|
|
regulation of proteasomal ubiquitin dependent protein catabolic process
|
GO:0032434 |
71 |
0.099
|
|
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.099
|
|
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.099
|
|
|
|
neural crest cell migration
|
GO:0001755 |
2 |
0.099
|
|
|
|
regulation of fibroblast migration
|
GO:0010762 |
7 |
0.099
|
|
|
|
cardiac chamber development
|
GO:0003205 |
30 |
0.098
|
Human |
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.098
|
|
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.098
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.097
|
|
|
|
cartilage development
|
GO:0051216 |
31 |
0.097
|
Human Mouse |
|
|
mesonephros development
|
GO:0001823 |
17 |
0.097
|
|
|
|
cell fate determination
|
GO:0001709 |
3 |
0.097
|
|
|
|
cytokine production
|
GO:0001816 |
247 |
0.096
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.096
|
|
|
|
negative regulation of systemic arterial blood pressure
|
GO:0003085 |
1 |
0.096
|
Human |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.095
|
|
|
|
neurogenesis
|
GO:0022008 |
169 |
0.094
|
Mouse Fly |
|
|
t cell activation
|
GO:0042110 |
99 |
0.094
|
|
|
|
positive regulation of cell motility
|
GO:2000147 |
177 |
0.094
|
Human |
|
|
regulation of cell development
|
GO:0060284 |
161 |
0.094
|
|
|
|
positive regulation of cell development
|
GO:0010720 |
92 |
0.094
|
|
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.093
|
|
|
|
establishment of protein localization to organelle
|
GO:0072594 |
172 |
0.093
|
|
|
|
neuronal action potential
|
GO:0019228 |
9 |
0.093
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.093
|
|
|
|
cell cell junction organization
|
GO:0045216 |
69 |
0.092
|
Human |
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.092
|
|
|
|
positive regulation of cellular protein catabolic process
|
GO:1903364 |
37 |
0.092
|
|
|
|
regeneration
|
GO:0031099 |
4 |
0.092
|
Rat |
|
|
regulation of chemotaxis
|
GO:0050920 |
74 |
0.092
|
|
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.091
|
|
|
|
regulation of system process
|
GO:0044057 |
101 |
0.090
|
|
|
|
endothelial cell fate commitment
|
GO:0060839 |
3 |
0.090
|
Human |
|
|
positive regulation of cell adhesion
|
GO:0045785 |
84 |
0.090
|
|
|
|
purine containing compound biosynthetic process
|
GO:0072522 |
88 |
0.090
|
|
|
|
purine ribonucleotide biosynthetic process
|
GO:0009152 |
79 |
0.089
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.089
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.089
|
|
|
|
epithelial cell proliferation
|
GO:0050673 |
128 |
0.089
|
Human Mouse |
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.088
|
|
|
|
regulation of hormone levels
|
GO:0010817 |
125 |
0.088
|
|
|
|
positive regulation of b cell mediated immunity
|
GO:0002714 |
4 |
0.088
|
|
|
|
regulation of phosphatidylinositol 3 kinase signaling
|
GO:0014066 |
35 |
0.088
|
|
|
|
embryonic morphogenesis
|
GO:0048598 |
85 |
0.088
|
Human Mouse |
|
|
hair cycle
|
GO:0042633 |
28 |
0.087
|
|
|
|
action potential
|
GO:0001508 |
34 |
0.087
|
|
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.087
|
|
|
|
regulation of axon guidance
|
GO:1902667 |
3 |
0.086
|
|
|
|
wnt signaling pathway
|
GO:0016055 |
156 |
0.086
|
|
|
|
ribonucleotide biosynthetic process
|
GO:0009260 |
81 |
0.086
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.086
|
Worm |
|
|
nodal signaling pathway
|
GO:0038092 |
5 |
0.086
|
Human |
|
|
gastrulation with mouth forming second
|
GO:0001702 |
1 |
0.086
|
|
|
|
regulation of feeding behavior
|
GO:0060259 |
3 |
0.086
|
|
|
|
regulation of wnt signaling pathway
|
GO:0030111 |
123 |
0.085
|
|
|
|
regulation of muscle organ development
|
GO:0048634 |
27 |
0.085
|
|
|
|
negative regulation of activin receptor signaling pathway
|
GO:0032926 |
6 |
0.085
|
Human |
|
|
gtp metabolic process
|
GO:0046039 |
239 |
0.085
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.085
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.085
|
|
|
|
positive regulation of behavior
|
GO:0048520 |
60 |
0.084
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.084
|
|
|
|
regulation of smooth muscle cell differentiation
|
GO:0051150 |
3 |
0.084
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.084
|
|
|
|
regulation of ketone biosynthetic process
|
GO:0010566 |
7 |
0.083
|
|
|
|
lymphocyte homeostasis
|
GO:0002260 |
4 |
0.083
|
|
|
|
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090100 |
41 |
0.082
|
|
|
|
biomineral tissue development
|
GO:0031214 |
39 |
0.082
|
Human |
|
|
kidney epithelium development
|
GO:0072073 |
25 |
0.082
|
|
|
|
branching involved in ureteric bud morphogenesis
|
GO:0001658 |
9 |
0.082
|
|
|
|
positive regulation of proteasomal protein catabolic process
|
GO:1901800 |
35 |
0.082
|
|
|
|
motor neuron axon guidance
|
GO:0008045 |
2 |
0.082
|
|
|
|
mitral valve development
|
GO:0003174 |
3 |
0.081
|
Human |
|
|
negative regulation of calcium ion transmembrane transport
|
GO:1903170 |
11 |
0.080
|
|
|
|
cardiac ventricle morphogenesis
|
GO:0003208 |
20 |
0.080
|
|
|
|
striated muscle cell proliferation
|
GO:0014855 |
7 |
0.080
|
|
|
|
regulation of growth
|
GO:0040008 |
165 |
0.079
|
|
|
|
positive regulation of cytosolic calcium ion concentration
|
GO:0007204 |
82 |
0.079
|
|
|
|
determination of bilateral symmetry
|
GO:0009855 |
15 |
0.079
|
Human |
|
|
regulation of cellular protein catabolic process
|
GO:1903362 |
96 |
0.079
|
|
|
|
heart morphogenesis
|
GO:0003007 |
48 |
0.079
|
Human |
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.079
|
|
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.079
|
|
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.079
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.079
|
Worm |
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.079
|
|
|
|
symbiosis encompassing mutualism through parasitism
|
GO:0044403 |
156 |
0.078
|
|
|
|
response to metal ion
|
GO:0010038 |
84 |
0.078
|
|
|
|
adherens junction organization
|
GO:0034332 |
36 |
0.078
|
Human |
|
|
proteasome mediated ubiquitin dependent protein catabolic process
|
GO:0043161 |
156 |
0.078
|
|
