Homo sapiens

123 known processes

THOC4

THO complex 4

(Aliases: REF,BEF,ALY/REF,ALY)

THOC4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
intracellular transport of virus GO:0075733 14 1.000
multi organism intracellular transport GO:1902583 14 1.000
mrna export from nucleus GO:0006406 29 1.000
mrna transport GO:0051028 30 1.000
multi organism localization GO:1902579 14 1.000
nucleobase containing compound transport GO:0015931 51 1.000
rna export from nucleus GO:0006405 33 1.000
rna transport GO:0050658 39 1.000
viral process GO:0016032 146 1.000
nucleic acid transport GO:0050657 39 1.000
establishment of rna localization GO:0051236 39 1.000
multi organism transport GO:0044766 14 1.000
positive regulation of dna templated transcription elongation GO:0032786 18 1.000
transport of virus GO:0046794 14 1.000
viral life cycle GO:0019058 132 1.000
viral mrna export from host cell nucleus GO:0046784 8 1.000
nuclear export GO:0051168 69 1.000
rna localization GO:0006403 41 1.000
cytoplasmic transport GO:0016482 379 1.000
symbiosis encompassing mutualism through parasitism GO:0044403 156 1.000
multi organism cellular process GO:0044764 156 0.999
interspecies interaction between organisms GO:0044419 156 0.999
nitrogen compound transport GO:0071705 191 0.999
nuclear transport GO:0051169 179 0.998
mrna metabolic process GO:0016071 175 0.997
regulation of dna templated transcription elongation GO:0032784 23 0.995
purine nucleoside monophosphate metabolic process GO:0009126 186 0.993
Yeast
ribonucleoside monophosphate catabolic process GO:0009158 158 0.991
Yeast
nucleoside monophosphate catabolic process GO:0009125 159 0.988
Yeast
dna damage checkpoint GO:0000077 68 0.980
mrna 3 end processing GO:0031124 24 0.976
replication fork processing GO:0031297 13 0.975
ribonucleoside catabolic process GO:0042454 406 0.975
Yeast
negative regulation of cell cycle checkpoint GO:1901977 4 0.961
mrna processing GO:0006397 133 0.960
purine nucleoside catabolic process GO:0006152 398 0.959
Yeast
glycosyl compound catabolic process GO:1901658 413 0.958
Yeast
purine ribonucleotide catabolic process GO:0009154 404 0.948
Yeast
nucleocytoplasmic transport GO:0006913 176 0.947
nucleoside phosphate catabolic process GO:1901292 412 0.943
Yeast
atp catabolic process GO:0006200 157 0.930
Yeast
regulation of dna damage checkpoint GO:2000001 9 0.930
nucleoside catabolic process GO:0009164 408 0.916
Yeast
dna templated transcription elongation GO:0006354 25 0.913
rna catabolic process GO:0006401 71 0.912
cellular response to dna damage stimulus GO:0006974 379 0.909
nucleoside monophosphate metabolic process GO:0009123 191 0.899
Yeast
negative regulation of dna damage checkpoint GO:2000002 4 0.885
nucleotide catabolic process GO:0009166 408 0.885
Yeast
rna processing GO:0006396 255 0.875
dna integrity checkpoint GO:0031570 71 0.865
nuclear transcribed mrna catabolic process GO:0000956 48 0.860
mrna splicing via spliceosome GO:0000398 89 0.860
purine ribonucleoside catabolic process GO:0046130 398 0.836
Yeast
regulation of atpase activity GO:0043462 25 0.835
Yeast
purine nucleoside triphosphate catabolic process GO:0009146 392 0.834
Yeast
mrna catabolic process GO:0006402 56 0.832
organophosphate catabolic process GO:0046434 430 0.826
Yeast
purine ribonucleoside metabolic process GO:0046128 437 0.817
Yeast
rna 3 end processing GO:0031123 35 0.815
rna splicing via transesterification reactions GO:0000375 90 0.813
primary mirna processing GO:0031053 3 0.798
cell cycle checkpoint GO:0000075 117 0.788
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.766
Yeast
ribonucleoside triphosphate catabolic process GO:0009203 391 0.761
Yeast
post embryonic development GO:0009791 2 0.756
nucleotide excision repair GO:0006289 31 0.755
Yeast
purine containing compound catabolic process GO:0072523 411 0.754
Yeast
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.741
Yeast
purine nucleoside monophosphate catabolic process GO:0009128 158 0.736
Yeast
dna recombination GO:0006310 77 0.730
nucleoside triphosphate catabolic process GO:0009143 394 0.716
Yeast
regulation of cellular response to stress GO:0080135 244 0.707
regulation of atp metabolic process GO:1903578 29 0.692
Yeast
dna repair GO:0006281 198 0.692
Yeast
translation GO:0006412 132 0.682
Human
spliceosomal complex assembly GO:0000245 17 0.679
regulation of nucleoside metabolic process GO:0009118 209 0.674
Yeast
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.667
Yeast
regulation of atp catabolic process GO:1903289 25 0.666
Yeast
atp metabolic process GO:0046034 176 0.656
Yeast
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.651
Yeast
female gamete generation GO:0007292 2 0.643
negative regulation of cell cycle process GO:0010948 121 0.577
regulation of mrna metabolic process GO:1903311 53 0.563
negative regulation of apoptotic process GO:0043066 316 0.561
regulation of response to dna damage stimulus GO:2001020 94 0.539
positive regulation of nucleotide metabolic process GO:0045981 230 0.532
chromatin organization GO:0006325 351 0.530
negative regulation of cell cycle GO:0045786 193 0.522
regulation of rna splicing GO:0043484 62 0.506
oogenesis GO:0048477 2 0.501
ribonucleoside triphosphate metabolic process GO:0009199 412 0.493
Yeast
response to abiotic stimulus GO:0009628 336 0.489
nucleoside triphosphate metabolic process GO:0009141 422 0.455
Yeast
regulation of cell cycle process GO:0010564 266 0.450
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 23 0.440
regulation of purine nucleotide metabolic process GO:1900542 264 0.426
Yeast
regulation of purine nucleotide catabolic process GO:0033121 205 0.426
Yeast
purine nucleotide catabolic process GO:0006195 405 0.421
Yeast
purine nucleoside triphosphate metabolic process GO:0009144 412 0.396
Yeast
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 89 0.394
organelle fission GO:0048285 149 0.389
negative regulation of immune response GO:0050777 40 0.376
nuclear division GO:0000280 128 0.349
regulation of translation GO:0006417 89 0.338
Human
negative regulation of response to dna damage stimulus GO:2001021 33 0.333
regulation of cell cycle GO:0051726 393 0.328
ribonucleotide catabolic process GO:0009261 405 0.269
Yeast
regulation of mrna splicing via spliceosome GO:0048024 32 0.266
response to organic cyclic compound GO:0014070 204 0.248
immune system development GO:0002520 195 0.231
immune effector process GO:0002252 159 0.216
alternative mrna splicing via spliceosome GO:0000380 27 0.206
negative regulation of immunoglobulin mediated immune response GO:0002890 3 0.200
negative regulation of immune system process GO:0002683 136 0.197
reproductive system development GO:0061458 56 0.196
positive regulation of nucleotide catabolic process GO:0030813 185 0.191
myeloid cell differentiation GO:0030099 117 0.188
ras protein signal transduction GO:0007265 73 0.185
transcription coupled nucleotide excision repair GO:0006283 8 0.181
Yeast
segmentation GO:0035282 4 0.179
rna splicing GO:0008380 131 0.171
positive regulation of catabolic process GO:0009896 310 0.169
microtubule cytoskeleton organization GO:0000226 176 0.168
regulation of meiosis GO:0040020 3 0.160
embryo development GO:0009790 123 0.159
regulation of dna recombination GO:0000018 23 0.157
regulation of meiotic cell cycle GO:0051445 4 0.150
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.150
negative regulation of viral process GO:0048525 66 0.150
ribonucleoside monophosphate metabolic process GO:0009161 187 0.146
Yeast
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.139
positive regulation of hydrolase activity GO:0051345 331 0.139
single organism reproductive process GO:0044702 98 0.138
cellular macromolecular complex assembly GO:0034622 324 0.137
regulation of multi organism process GO:0043900 157 0.133
chromatin silencing GO:0006342 12 0.132
negative regulation of programmed cell death GO:0043069 321 0.126
negative regulation of gene expression epigenetic GO:0045814 19 0.124
ribonucleoprotein complex assembly GO:0022618 78 0.120
regulation of b cell activation GO:0050864 24 0.113
positive regulation of nucleoside metabolic process GO:0045979 186 0.110
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.109
viral genome replication GO:0019079 50 0.106
reproductive process GO:0022414 106 0.106
regulation of cell development GO:0060284 161 0.105
chromosome segregation GO:0007059 114 0.102
intracellular mrna localization GO:0008298 1 0.099
gonad development GO:0008406 34 0.098
hematopoietic or lymphoid organ development GO:0048534 186 0.095
negative regulation of viral genome replication GO:0045071 35 0.095
regulation of immune response GO:0050776 201 0.091
anterior posterior axis specification embryo GO:0008595 2 0.089
cellular macromolecule catabolic process GO:0044265 380 0.085
lymphocyte mediated immunity GO:0002449 48 0.085
regulation of viral process GO:0050792 103 0.085
sex differentiation GO:0007548 45 0.085
b cell activation GO:0042113 33 0.084
negative regulation of b cell mediated immunity GO:0002713 3 0.084
mitotic cell cycle process GO:1903047 286 0.084
regulation of cell cycle checkpoint GO:1901976 21 0.083
regulation of gene expression epigenetic GO:0040029 73 0.077
anterior posterior axis specification GO:0009948 2 0.076
positive regulation of atpase activity GO:0032781 19 0.074
regulation of viral genome replication GO:0045069 48 0.073
regulation of cell activation GO:0050865 125 0.071
oocyte differentiation GO:0009994 2 0.068
oocyte development GO:0048599 1 0.068
developmental process involved in reproduction GO:0003006 66 0.067
meiotic chromosome segregation GO:0045132 4 0.063
production of sirna involved in rna interference GO:0030422 3 0.061
negative regulation of cellular protein metabolic process GO:0032269 353 0.060
rna capping GO:0036260 10 0.059
immune response GO:0006955 307 0.058
membrane organization GO:0061024 292 0.057
chromatin remodeling GO:0006338 55 0.057
protein ubiquitination GO:0016567 314 0.056
negative regulation of protein metabolic process GO:0051248 391 0.056
blastoderm segmentation GO:0007350 2 0.055
single organism cellular localization GO:1902580 332 0.054
regulation of cell cycle phase transition GO:1901987 126 0.053
positive regulation of cellular catabolic process GO:0031331 284 0.053
tripartite regional subdivision GO:0007351 2 0.052
negative regulation of translation GO:0017148 37 0.051
protein complex disassembly GO:0043241 52 0.051
cell activation GO:0001775 213 0.049
regulation of alternative mrna splicing via spliceosome GO:0000381 22 0.049
mitotic cell cycle GO:0000278 326 0.049
regulation of immune effector process GO:0002697 91 0.048
cellular lipid metabolic process GO:0044255 303 0.047
negative regulation of production of molecular mediator of immune response GO:0002701 13 0.045
positive regulation of atp catabolic process GO:1903291 19 0.045
negative regulation of multicellular organismal process GO:0051241 317 0.045
lymphocyte activation involved in immune response GO:0002285 20 0.045
determination of adult lifespan GO:0008340 2 0.045
ribonucleoprotein complex subunit organization GO:0071826 81 0.044
chromatin modification GO:0016568 298 0.043
gene silencing GO:0016458 49 0.043
protein import GO:0017038 130 0.043
nucleus localization GO:0051647 1 0.042
leukocyte mediated immunity GO:0002443 59 0.042
gtp metabolic process GO:0046039 239 0.041
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.040
regulation of cell division GO:0051302 116 0.039
macromolecular complex disassembly GO:0032984 60 0.039
reproductive structure development GO:0048608 55 0.039
single organism membrane organization GO:0044802 268 0.037
establishment of nucleus localization GO:0040023 1 0.037
regulation of endopeptidase activity GO:0052548 170 0.037
regulation of leukocyte mediated immunity GO:0002703 38 0.037
embryo development ending in birth or egg hatching GO:0009792 34 0.037
dna replication GO:0006260 116 0.037
regulation of proteolysis GO:0030162 293 0.036
development of primary sexual characteristics GO:0045137 35 0.035
regulation of oocyte development GO:0060281 1 0.035
regulation of cellular component biogenesis GO:0044087 281 0.035
positive regulation of intracellular protein transport GO:0090316 76 0.035
dephosphorylation GO:0016311 209 0.035
regulation of leukocyte activation GO:0002694 115 0.034
regulation of nuclear division GO:0051783 65 0.034
response to nitrogen compound GO:1901698 184 0.033
protein localization to organelle GO:0033365 280 0.032
negative regulation of hydrolase activity GO:0051346 182 0.032
Yeast
regulation of mitotic cell cycle GO:0007346 189 0.031
regulation of mrna processing GO:0050684 48 0.031
cellular response to oxygen containing compound GO:1901701 276 0.031
small gtpase mediated signal transduction GO:0007264 78 0.031
enzyme linked receptor protein signaling pathway GO:0007167 303 0.031
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.031
response to oxygen containing compound GO:1901700 369 0.030
mitochondrial transport GO:0006839 60 0.030
microtubule based process GO:0007017 210 0.030
regulation of isotype switching GO:0045191 2 0.030
positive regulation of translation GO:0045727 35 0.030
Human
response to biotic stimulus GO:0009607 276 0.029
regulation of nucleotide catabolic process GO:0030811 205 0.029
Yeast
7 methylguanosine rna capping GO:0009452 9 0.029
isotype switching GO:0045190 3 0.029
innate immune response GO:0045087 178 0.028
regulation of cell maturation GO:1903429 3 0.028
regulation of lymphocyte activation GO:0051249 103 0.027
regulation of myeloid cell differentiation GO:0045637 81 0.027
locomotory behavior GO:0007626 1 0.026
negative regulation of cellular component organization GO:0051129 235 0.026
gtp catabolic process GO:0006184 237 0.026
meiotic cell cycle GO:0051321 13 0.026
histone modification GO:0016570 251 0.025
intracellular protein transport GO:0006886 270 0.023
regulation of lymphocyte mediated immunity GO:0002706 33 0.023
establishment of organelle localization GO:0051656 59 0.023
somatic cell dna recombination GO:0016444 6 0.023
engulfment of apoptotic cell GO:0043652 2 0.022
leukocyte activation involved in immune response GO:0002366 30 0.022
nuclear migration GO:0007097 1 0.022
mrna cis splicing via spliceosome GO:0045292 7 0.021
defense response GO:0006952 315 0.021
positive regulation of mapk cascade GO:0043410 190 0.021
epithelium development GO:0060429 227 0.021
establishment of protein localization to organelle GO:0072594 172 0.021
cardiovascular system development GO:0072358 262 0.021
guanosine containing compound catabolic process GO:1901069 239 0.021
cellular response to organic cyclic compound GO:0071407 127 0.021
negative regulation of catalytic activity GO:0043086 335 0.021
Yeast
lymphocyte activation GO:0046649 133 0.020
hemopoiesis GO:0030097 180 0.020
cellular protein complex disassembly GO:0043624 36 0.020
response to temperature stimulus GO:0009266 22 0.020
negative regulation of developmental process GO:0051093 247 0.020
negative regulation of mitotic cell cycle GO:0045930 102 0.020
multicellular organismal reproductive process GO:0048609 40 0.020
negative regulation of cell death GO:0060548 345 0.019
reproduction GO:0000003 63 0.019
Worm
7 methylguanosine mrna capping GO:0006370 7 0.019
positive regulation of transport GO:0051050 336 0.018
negative regulation of b cell activation GO:0050869 6 0.018
response to external biotic stimulus GO:0043207 261 0.018
positive regulation of cell proliferation GO:0008284 301 0.018
regulation of synaptic plasticity GO:0048167 3 0.018
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.018
lipid metabolic process GO:0006629 381 0.018
generation of neurons GO:0048699 152 0.018
multi organism reproductive process GO:0044703 54 0.017
protein localization to nucleus GO:0034504 136 0.017
cation transport GO:0006812 331 0.017
isotype switching to iga isotypes GO:0048290 2 0.017
protein complex localization GO:0031503 31 0.017
leukocyte differentiation GO:0002521 98 0.017
ncrna processing GO:0034470 83 0.017
response to other organism GO:0051707 261 0.016
regionalization GO:0003002 29 0.016
anatomical structure formation involved in morphogenesis GO:0048646 284 0.016
regulation of gtp catabolic process GO:0033124 180 0.016
central nervous system development GO:0007417 123 0.016
adaptive immune response GO:0002250 49 0.016
ubiquitin dependent protein catabolic process GO:0006511 206 0.016
taxis GO:0042330 157 0.016
vesicle mediated transport GO:0016192 371 0.016
regulation of growth GO:0040008 165 0.016
dna dependent dna replication GO:0006261 44 0.015
negative regulation of multi organism process GO:0043901 92 0.015
transmembrane transport GO:0055085 399 0.015
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.015
regulation of adaptive immune response GO:0002819 33 0.015
organic hydroxy compound metabolic process GO:1901615 147 0.015
negative regulation of cell cycle phase transition GO:1901988 89 0.015
protein targeting GO:0006605 187 0.015
negative regulation of intracellular signal transduction GO:1902532 183 0.015
regulation of peptidase activity GO:0052547 180 0.015
cellular response to hypoxia GO:0071456 51 0.015
negative regulation of cell differentiation GO:0045596 171 0.015
cell development GO:0048468 328 0.015
glycerolipid metabolic process GO:0046486 107 0.015
response to decreased oxygen levels GO:0036293 96 0.015
response to hormone GO:0009725 175 0.014
regulation of protein maturation GO:1903317 150 0.014
protein maturation GO:0051604 233 0.014
endocytosis GO:0006897 159 0.014
regulation of isotype switching to iga isotypes GO:0048296 2 0.014
lipid catabolic process GO:0016042 84 0.014
negative regulation of apoptotic signaling pathway GO:2001234 97 0.014
regulation of cell differentiation GO:0045595 393 0.014
response to hypoxia GO:0001666 96 0.014
secretion GO:0046903 254 0.014
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.014
positive regulation of growth GO:0045927 58 0.013
positive regulation of developmental growth GO:0048639 16 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.013
Human
regulation of intracellular protein transport GO:0033157 123 0.013
regulation of ligase activity GO:0051340 29 0.013
regulation of protein localization GO:0032880 296 0.013
inflammatory response GO:0006954 79 0.013
positive regulation of atp metabolic process GO:1903580 20 0.013
cellular response to nitrogen compound GO:1901699 144 0.013
cilium organization GO:0044782 68 0.013
stem cell development GO:0048864 69 0.012
protein k11 linked ubiquitination GO:0070979 24 0.012
regulation of ras protein signal transduction GO:0046578 155 0.012
positive regulation of ras gtpase activity GO:0032320 117 0.012
actin filament based process GO:0030029 224 0.012
regulation of apoptotic signaling pathway GO:2001233 175 0.012
protein processing GO:0016485 226 0.012
biological adhesion GO:0022610 331 0.012
cellular protein catabolic process GO:0044257 261 0.012
regulation of cysteine type endopeptidase activity GO:2000116 127 0.012
cell adhesion GO:0007155 325 0.011
regulation of small gtpase mediated signal transduction GO:0051056 156 0.011
metal ion transport GO:0030001 272 0.011
chemical homeostasis GO:0048878 306 0.011
mitotic spindle organization GO:0007052 27 0.011
negative regulation of leukocyte mediated immunity GO:0002704 14 0.011
rna interference GO:0016246 4 0.011
positive regulation of programmed cell death GO:0043068 249 0.011
nuclear mrna surveillance GO:0071028 4 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.011
sexual reproduction GO:0019953 37 0.011
phospholipid metabolic process GO:0006644 99 0.011
macromolecule methylation GO:0043414 97 0.011
apoptotic mitochondrial changes GO:0008637 57 0.011
spermatid differentiation GO:0048515 4 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.011
secretion by cell GO:0032940 226 0.011
mapk cascade GO:0000165 288 0.011
sex determination GO:0007530 3 0.011
rna secondary structure unwinding GO:0010501 3 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.010
gamete generation GO:0007276 25 0.010
covalent chromatin modification GO:0016569 254 0.010
adult locomotory behavior GO:0008344 1 0.010
muscle system process GO:0003012 81 0.010
positive regulation of developmental process GO:0051094 314 0.010
nucleosome assembly GO:0006334 50 0.010

THOC4 disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.015
disease of cellular proliferation DOID:14566 174 0.015
organ system cancer DOID:0050686 164 0.015
disease of mental health DOID:150 70 0.010
central nervous system disease DOID:331 186 0.010
nervous system disease DOID:863 431 0.010