Homo sapiens

204 known processes

TIRAP

toll-interleukin 1 receptor (TIR) domain containing adaptor protein

(Aliases: wyatt,FLJ42305,Mal)

TIRAP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to bacterial lipoprotein GO:0071220 3 1.000
Mouse
cellular response to triacyl bacterial lipopeptide GO:0071727 2 1.000
detection of bacterial lipoprotein GO:0042494 3 1.000
interferon alpha biosynthetic process GO:0045349 4 1.000
response to triacyl bacterial lipopeptide GO:0071725 2 1.000
regulation of interferon alpha biosynthetic process GO:0045354 4 1.000
detection of diacyl bacterial lipopeptide GO:0042496 2 1.000
cellular response to diacyl bacterial lipopeptide GO:0071726 2 0.999
i kappab phosphorylation GO:0007252 7 0.999
interleukin 17 production GO:0032620 12 0.999
positive regulation of interferon beta biosynthetic process GO:0045359 4 0.999
growth of symbiont involved in interaction with host GO:0044116 2 0.998
Mouse
positive regulation of interferon alpha biosynthetic process GO:0045356 4 0.998
toll like receptor 2 signaling pathway GO:0034134 4 0.998
positive regulation of toll like receptor signaling pathway GO:0034123 10 0.996
positive regulation of lipopolysaccharide mediated signaling pathway GO:0031666 4 0.996
detection of triacyl bacterial lipopeptide GO:0042495 2 0.995
response to bacterial lipopeptide GO:0070339 3 0.995
Mouse
regulation of interleukin 17 production GO:0032660 12 0.994
chemokine biosynthetic process GO:0042033 4 0.993
defense response to other organism GO:0098542 129 0.993
Mouse
regulation of interferon beta biosynthetic process GO:0045357 4 0.990
regulation of chemokine biosynthetic process GO:0045073 4 0.989
response to other organism GO:0051707 261 0.989
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.988
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.985
interleukin 6 production GO:0032635 37 0.985
defense response GO:0006952 315 0.984
positive regulation of interleukin 23 production GO:0032747 4 0.984
i kappab kinase nf kappab signaling GO:0007249 166 0.980
response to external biotic stimulus GO:0043207 261 0.979
positive regulation of chemokine production GO:0032722 22 0.978
Mouse
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.975
detection of bacterial lipopeptide GO:0070340 3 0.975
detection of molecule of bacterial origin GO:0032490 10 0.973
negative regulation of growth of symbiont involved in interaction with host GO:0044146 2 0.972
Mouse
positive regulation of cytokine production GO:0001819 167 0.972
chemokine metabolic process GO:0050755 4 0.972
chemokine production GO:0032602 32 0.969
Mouse
activation of protein kinase activity GO:0032147 90 0.963
antifungal humoral response GO:0019732 2 0.958
regulation of chemokine production GO:0032642 31 0.957
Mouse
cellular response to bacterial lipopeptide GO:0071221 3 0.955
Mouse
immune effector process GO:0002252 159 0.952
mapk cascade GO:0000165 288 0.946
response to biotic stimulus GO:0009607 276 0.943
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.939
cellular response to molecule of bacterial origin GO:0071219 62 0.936
Mouse
positive regulation of defense response GO:0031349 87 0.935
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.934
negative regulation of tumor necrosis factor production GO:0032720 20 0.933
positive regulation of chemokine biosynthetic process GO:0045080 3 0.932
positive regulation of phosphorylation GO:0042327 394 0.923
positive regulation of map kinase activity GO:0043406 80 0.920
regulation of toll like receptor signaling pathway GO:0034121 17 0.913
toll like receptor signaling pathway GO:0002224 25 0.911
defense response to fungus GO:0050832 4 0.907
positive regulation of interleukin 8 biosynthetic process GO:0045416 8 0.907
defense response to virus GO:0051607 71 0.904
positive regulation of cytokine biosynthetic process GO:0042108 25 0.899
positive regulation of mapk cascade GO:0043410 190 0.898
regulation of tumor necrosis factor production GO:0032680 43 0.897
innate immune response activating signal transduction GO:0002758 48 0.889
defense response to bacterium GO:0042742 63 0.889
Mouse
positive regulation of innate immune response GO:0045089 79 0.886
positive regulation of cell proliferation GO:0008284 301 0.880
Mouse
response to cytokine GO:0034097 232 0.877
response to wounding GO:0009611 168 0.876
response to bacterial lipoprotein GO:0032493 3 0.875
Mouse
regulation of mapk cascade GO:0043408 262 0.874
activation of innate immune response GO:0002218 55 0.874
regulation of immune response GO:0050776 201 0.867
regulation of nucleocytoplasmic transport GO:0046822 98 0.867
signal transduction by phosphorylation GO:0023014 297 0.865
response to fungus GO:0009620 4 0.862
regulation of protein serine threonine kinase activity GO:0071900 179 0.857
cytokine mediated signaling pathway GO:0019221 109 0.856
growth involved in symbiotic interaction GO:0044110 2 0.842
Mouse
regulation of jnk cascade GO:0046328 73 0.840
positive regulation of cellular amine metabolic process GO:0033240 7 0.839
toll like receptor 4 signaling pathway GO:0034142 12 0.839
cellular response to cytokine stimulus GO:0071345 181 0.833
positive regulation of jnk cascade GO:0046330 52 0.831
lipopolysaccharide mediated signaling pathway GO:0031663 26 0.825
regulation of mononuclear cell proliferation GO:0032944 65 0.817
Mouse
negative regulation of interleukin 17 production GO:0032700 5 0.811
regulation of interleukin 6 production GO:0032675 37 0.808
positive regulation of protein kinase activity GO:0045860 190 0.805
positive regulation of toll like receptor 4 signaling pathway GO:0034145 6 0.805
immune response GO:0006955 307 0.800
positive regulation of mononuclear cell proliferation GO:0032946 47 0.798
Mouse
positive regulation of stress activated protein kinase signaling cascade GO:0070304 61 0.798
regulation of leukocyte proliferation GO:0070663 67 0.785
Mouse
positive regulation of nitric oxide synthase biosynthetic process GO:0051770 3 0.782
pattern recognition receptor signaling pathway GO:0002221 48 0.771
immune response activating signal transduction GO:0002757 90 0.769
response to virus GO:0009615 126 0.759
positive regulation of lymphocyte proliferation GO:0050671 46 0.757
Mouse
positive regulation of cell activation GO:0050867 81 0.756
Mouse
negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556 20 0.751
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.750
positive regulation of protein phosphorylation GO:0001934 313 0.750
regulation of sensory perception GO:0051931 3 0.750
reactive oxygen species metabolic process GO:0072593 75 0.741
negative regulation of growth of symbiont in host GO:0044130 1 0.738
Mouse
response to activity GO:0014823 0 0.729
regulation of transferase activity GO:0051338 355 0.725
nucleotide binding oligomerization domain containing signaling pathway GO:0070423 4 0.720
cytokine production GO:0001816 247 0.711
positive regulation of leukocyte proliferation GO:0070665 48 0.710
Mouse
immune response regulating signaling pathway GO:0002764 97 0.709
activation of mapk activity GO:0000187 45 0.700
regulation of cytokine mediated signaling pathway GO:0001959 41 0.695
jnk cascade GO:0007254 80 0.692
detection of lipopolysaccharide GO:0032497 3 0.690
regulation of cellular amino acid metabolic process GO:0006521 6 0.678
regulation of mhc class ii biosynthetic process GO:0045346 4 0.668
antimicrobial humoral response GO:0019730 26 0.665
skeletal muscle contraction GO:0003009 16 0.660
single organism nuclear import GO:1902593 104 0.657
cellular amine metabolic process GO:0044106 41 0.655
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.653
negative regulation of multicellular organismal process GO:0051241 317 0.651
positive regulation of nf kappab import into nucleus GO:0042346 13 0.649
mhc class ii biosynthetic process GO:0045342 4 0.646
negative regulation of cytokine production GO:0001818 82 0.646
response to hypoxia GO:0001666 96 0.645
inflammatory response GO:0006954 79 0.644
protein autophosphorylation GO:0046777 123 0.642
type i interferon biosynthetic process GO:0045351 4 0.624
protein import into nucleus GO:0006606 104 0.623
regulation of kinase activity GO:0043549 314 0.618
positive regulation of interleukin 8 production GO:0032757 36 0.604
regulation of cellular amine metabolic process GO:0033238 11 0.602
musculoskeletal movement GO:0050881 17 0.593
type i interferon production GO:0032606 27 0.577
Mouse
positive regulation of jun kinase activity GO:0043507 23 0.561
cell activation GO:0001775 213 0.559
Mouse
positive regulation of interleukin 17 production GO:0032740 8 0.559
positive regulation of mhc class ii biosynthetic process GO:0045348 3 0.549
anatomical structure homeostasis GO:0060249 100 0.548
positive regulation of immune response GO:0050778 159 0.534
transcription factor import into nucleus GO:0042991 40 0.529
positive regulation of smooth muscle cell proliferation GO:0048661 14 0.524
regulation of defense response GO:0031347 154 0.520
regulation of protein kinase activity GO:0045859 289 0.513
cellular response to oxygen containing compound GO:1901701 276 0.512
Mouse
cytokine biosynthetic process GO:0042089 37 0.507
regulation of response to wounding GO:1903034 101 0.493
response to bacterium GO:0009617 144 0.486
response to nitrogen compound GO:1901698 184 0.486
stress activated mapk cascade GO:0051403 93 0.484
protein localization to nucleus GO:0034504 136 0.482
response to peptidoglycan GO:0032494 3 0.482
regulation of protein transport GO:0051223 213 0.462
humoral immune response GO:0006959 49 0.460
activation of immune response GO:0002253 114 0.460
positive regulation of interleukin 1 production GO:0032732 14 0.457
regulation of response to external stimulus GO:0032101 222 0.448
Mouse
positive regulation of kinase activity GO:0033674 204 0.447
positive regulation of transferase activity GO:0051347 227 0.444
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.444
amine metabolic process GO:0009308 44 0.443
dorsal ventral pattern formation GO:0009953 15 0.441
positive regulation of humoral immune response GO:0002922 3 0.439
innate immune response GO:0045087 178 0.437
associative learning GO:0008306 1 0.433
regulation of cytokine production GO:0001817 232 0.420
regulation of cellular response to stress GO:0080135 244 0.410
regulation of innate immune response GO:0045088 97 0.393
regulation of interleukin 12 biosynthetic process GO:0045075 1 0.389
muscle contraction GO:0006936 73 0.385
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.376
lymphocyte activation GO:0046649 133 0.372
Mouse
interleukin 8 production GO:0032637 51 0.371
regulation of immune effector process GO:0002697 91 0.365
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.358
regulation of smooth muscle cell proliferation GO:0048660 28 0.358
response to lipid GO:0033993 206 0.357
regulation of cell activation GO:0050865 125 0.354
Mouse
negative regulation of phosphorylation GO:0042326 174 0.349
organophosphate biosynthetic process GO:0090407 163 0.346
positive regulation of apoptotic process GO:0043065 246 0.345
response to diacyl bacterial lipopeptide GO:0071724 2 0.344
growth of symbiont in host GO:0044117 1 0.344
Mouse
regulation of production of molecular mediator of immune response GO:0002700 25 0.338
muscle cell proliferation GO:0033002 35 0.336
positive regulation of lymphocyte activation GO:0051251 73 0.335
Mouse
regulation of lymphocyte proliferation GO:0050670 64 0.334
Mouse
regulation of cellular ketone metabolic process GO:0010565 50 0.334
microglial cell activation GO:0001774 2 0.333
negative regulation of intracellular signal transduction GO:1902532 183 0.329
positive regulation of intracellular protein transport GO:0090316 76 0.328
regulation of transcription factor import into nucleus GO:0042990 39 0.323
regulation of inflammatory response GO:0050727 46 0.323
cellular lipid metabolic process GO:0044255 303 0.322
single organism cellular localization GO:1902580 332 0.321
establishment of endothelial barrier GO:0061028 16 0.319
cellular amino acid metabolic process GO:0006520 116 0.317
detection of external biotic stimulus GO:0098581 19 0.314
negative regulation of cholesterol transport GO:0032375 8 0.312
fatty acid derivative metabolic process GO:1901568 35 0.310
positive regulation of antimicrobial humoral response GO:0002760 1 0.306
positive regulation of protein localization to nucleus GO:1900182 48 0.306
cellular response to interleukin 12 GO:0071349 3 0.304
regulation of lipopolysaccharide mediated signaling pathway GO:0031664 13 0.293
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.290
rhythmic behavior GO:0007622 2 0.290
regulation of establishment of protein localization GO:0070201 242 0.289
regulation of interleukin 12 production GO:0032655 15 0.288
Mouse
muscle system process GO:0003012 81 0.288
purine containing compound catabolic process GO:0072523 411 0.287
response to molecule of bacterial origin GO:0002237 82 0.284
modulation of growth of symbiont involved in interaction with host GO:0044144 2 0.281
Mouse
response to oxygen levels GO:0070482 100 0.276
regulation of synaptic plasticity GO:0048167 3 0.275
fatty acid metabolic process GO:0006631 115 0.275
regulation of stress activated mapk cascade GO:0032872 84 0.275
sensory perception of pain GO:0019233 4 0.274
positive regulation of interleukin 6 production GO:0032755 21 0.273
positive regulation of response to external stimulus GO:0032103 88 0.272
Mouse
circadian behavior GO:0048512 2 0.272
astrocyte differentiation GO:0048708 4 0.272
response to oxidative stress GO:0006979 121 0.272
defense response to gram negative bacterium GO:0050829 14 0.264
regulation of sensory perception of pain GO:0051930 3 0.262
leukocyte proliferation GO:0070661 74 0.260
Mouse
positive regulation of interferon beta production GO:0032728 17 0.260
positive regulation of tumor necrosis factor production GO:0032760 21 0.255
mononuclear cell proliferation GO:0032943 71 0.255
Mouse
cell development GO:0048468 328 0.251
response to oxygen containing compound GO:1901700 369 0.250
tumor necrosis factor production GO:0032640 43 0.249
regulation of leukocyte activation GO:0002694 115 0.247
Mouse
interleukin 12 production GO:0032615 15 0.245
Mouse
icosanoid metabolic process GO:0006690 35 0.244
positive regulation of blood coagulation GO:0030194 11 0.243
tissue homeostasis GO:0001894 63 0.243
multicellular organismal aging GO:0010259 3 0.241
nuclear transport GO:0051169 179 0.241
type i interferon signaling pathway GO:0060337 11 0.240
protein localization to organelle GO:0033365 280 0.233
response to organonitrogen compound GO:0010243 156 0.233
regulation of intracellular transport GO:0032386 195 0.228
regionalization GO:0003002 29 0.226
cellular ketone metabolic process GO:0042180 80 0.225
positive regulation of transcription factor import into nucleus GO:0042993 25 0.225
unsaturated fatty acid metabolic process GO:0033559 37 0.223
determination of adult lifespan GO:0008340 2 0.222
response to decreased oxygen levels GO:0036293 96 0.222
regulation of jun kinase activity GO:0043506 27 0.219
regulation of cytokine biosynthetic process GO:0042035 35 0.219
smooth muscle cell proliferation GO:0048659 28 0.216
interleukin 23 production GO:0032627 5 0.214
cellular response to external stimulus GO:0071496 111 0.214
myeloid leukocyte activation GO:0002274 34 0.213
post embryonic development GO:0009791 2 0.211
negative regulation of mapk cascade GO:0043409 56 0.208
nitric oxide biosynthetic process GO:0006809 20 0.206
regulation of cytoplasmic transport GO:1903649 149 0.206
response to toxic substance GO:0009636 37 0.206
cell migration involved in gastrulation GO:0042074 1 0.204
positive regulation of protein import into nucleus GO:0042307 46 0.204
regulation of interleukin 10 production GO:0032653 16 0.201
photoreceptor cell differentiation GO:0046530 2 0.201
stress activated protein kinase signaling cascade GO:0031098 94 0.201
regulation of tor signaling GO:0032006 30 0.201
interferon gamma production GO:0032609 39 0.192
regulation of interferon alpha production GO:0032647 11 0.191
nucleotide binding oligomerization domain containing 2 signaling pathway GO:0070431 4 0.191
erk1 and erk2 cascade GO:0070371 104 0.190
establishment of protein localization to organelle GO:0072594 172 0.189
regulation of reactive oxygen species metabolic process GO:2000377 41 0.188
protein targeting GO:0006605 187 0.187
b cell activation GO:0042113 33 0.186
Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 75 0.184
protein targeting to nucleus GO:0044744 104 0.178
negative regulation of phosphate metabolic process GO:0045936 267 0.174
purine nucleotide catabolic process GO:0006195 405 0.173
reactive oxygen species biosynthetic process GO:1903409 4 0.173
platelet activation GO:0030168 44 0.169
rna stabilization GO:0043489 18 0.168
positive regulation of cytokine mediated signaling pathway GO:0001961 12 0.167
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.164
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.163
nitrogen compound transport GO:0071705 191 0.162
nucleotide catabolic process GO:0009166 408 0.162
negative regulation of protein phosphorylation GO:0001933 140 0.162
locomotory behavior GO:0007626 1 0.161
pattern specification process GO:0007389 43 0.160
immunoglobulin mediated immune response GO:0016064 10 0.158
regulation of rna stability GO:0043487 23 0.157
protein import GO:0017038 130 0.156
neurological system process GO:0050877 163 0.156
striated muscle contraction GO:0006941 52 0.155
positive regulation of type i interferon production GO:0032481 20 0.152
epithelial cell differentiation GO:0030855 141 0.152
ras protein signal transduction GO:0007265 73 0.152
lipid metabolic process GO:0006629 381 0.151
cellular response to endogenous stimulus GO:0071495 336 0.150
peripheral nervous system development GO:0007422 2 0.148
negative regulation of catabolic process GO:0009895 104 0.148
regulation of wound healing GO:0061041 56 0.148
response to lipopolysaccharide GO:0032496 70 0.147
blood coagulation GO:0007596 76 0.147
organophosphate catabolic process GO:0046434 430 0.147
regulation of growth GO:0040008 165 0.144
Mouse
epithelial structure maintenance GO:0010669 9 0.144
regulation of cytokine production involved in immune response GO:0002718 22 0.139
positive regulation of immune effector process GO:0002699 40 0.138
cellular response to mechanical stimulus GO:0071260 39 0.136
reactive nitrogen species metabolic process GO:2001057 3 0.136
protein catabolic process GO:0030163 325 0.136
cellular response to lipopolysaccharide GO:0071222 57 0.136
nucleoside triphosphate metabolic process GO:0009141 422 0.135
regulation of nf kappab import into nucleus GO:0042345 22 0.128
lymphocyte mediated immunity GO:0002449 48 0.127
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.127
long term memory GO:0007616 2 0.126
protein homooligomerization GO:0051260 100 0.125
protein ubiquitination GO:0016567 314 0.125
visual learning GO:0008542 1 0.125
glycosyl compound catabolic process GO:1901658 413 0.122
regulation of interleukin 1 production GO:0032652 21 0.121
segmentation GO:0035282 4 0.120
regulation of antimicrobial humoral response GO:0002759 1 0.120
regulation of nitric oxide synthase biosynthetic process GO:0051769 6 0.120
cellular response to biotic stimulus GO:0071216 71 0.118
Mouse
positive regulation of interleukin 12 production GO:0032735 8 0.117
Mouse
system process GO:0003008 349 0.117
3 utr mediated mrna stabilization GO:0070935 8 0.117
regulation of macrophage cytokine production GO:0010935 4 0.115
nf kappab import into nucleus GO:0042348 22 0.114
regulation of response to cytokine stimulus GO:0060759 46 0.112
growth GO:0040007 202 0.111
Mouse
cytoplasmic transport GO:0016482 379 0.111
negative regulation of protein catabolic process GO:0042177 59 0.110
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.110
digestion GO:0007586 22 0.110
defense response to gram positive bacterium GO:0050830 29 0.109
Mouse
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.109
regulation of multi organism process GO:0043900 157 0.108
Mouse
regulation of neuronal synaptic plasticity GO:0048168 1 0.108
glycerophospholipid metabolic process GO:0006650 84 0.107
positive regulation of immune system process GO:0002684 283 0.107
cellular response to abiotic stimulus GO:0071214 117 0.106
regulation of nucleotide biosynthetic process GO:0030808 50 0.105
negative regulation of cell proliferation GO:0008285 228 0.105
regulation of interferon gamma production GO:0032649 36 0.104
nucleoside phosphate catabolic process GO:1901292 412 0.103
purine nucleoside triphosphate metabolic process GO:0009144 412 0.103
oogenesis GO:0048477 2 0.102
negative regulation of cellular component organization GO:0051129 235 0.101
determination of dorsal ventral asymmetry GO:0048262 4 0.101
b cell mediated immunity GO:0019724 10 0.100
spinal cord development GO:0021510 4 0.100
response to organic cyclic compound GO:0014070 204 0.100
regulation of growth of symbiont in host GO:0044126 1 0.099
Mouse
lymphocyte proliferation GO:0046651 70 0.099
Mouse
negative regulation of interleukin 12 production GO:0032695 6 0.098
protein modification by small protein conjugation GO:0032446 342 0.097
regulation of cell substrate adhesion GO:0010810 68 0.097
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 85 0.096
neuromuscular junction development GO:0007528 3 0.096
toll signaling pathway GO:0008063 2 0.096
response to fatty acid GO:0070542 13 0.096
positive regulation of leukocyte activation GO:0002696 80 0.096
Mouse
wound healing GO:0042060 115 0.095
peptidyl tyrosine modification GO:0018212 170 0.094
regulation of map kinase activity GO:0043405 108 0.094
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.092
regulation of interleukin 23 production GO:0032667 5 0.092
positive regulation of transport GO:0051050 336 0.092
peptidyl tyrosine phosphorylation GO:0018108 170 0.091
negative regulation of protein metabolic process GO:0051248 391 0.091
deoxyribonucleotide metabolic process GO:0009262 6 0.091
leukocyte activation involved in immune response GO:0002366 30 0.091
detection of other organism GO:0098543 13 0.091
cytokine metabolic process GO:0042107 38 0.090
purine nucleoside triphosphate catabolic process GO:0009146 392 0.090
nucleocytoplasmic transport GO:0006913 176 0.087
visual behavior GO:0007632 2 0.086
ameboidal type cell migration GO:0001667 135 0.084
response to mechanical stimulus GO:0009612 51 0.083
positive regulation of interferon alpha production GO:0032727 11 0.083
nucleoside triphosphate catabolic process GO:0009143 394 0.083
blastoderm segmentation GO:0007350 2 0.082
multicellular organismal movement GO:0050879 17 0.080
leukocyte mediated immunity GO:0002443 59 0.078
production of molecular mediator of immune response GO:0002440 37 0.078
positive regulation of nucleoside metabolic process GO:0045979 186 0.078
monocarboxylic acid metabolic process GO:0032787 185 0.078
positive regulation of cytoplasmic transport GO:1903651 82 0.078
cellular macromolecule catabolic process GO:0044265 380 0.077
regulation of intracellular protein transport GO:0033157 123 0.077
regulation of binding GO:0051098 111 0.077
positive regulation of b cell activation GO:0050871 17 0.076
Mouse
digestive system process GO:0022600 17 0.076
mrna stabilization GO:0048255 18 0.075
regulation of protein import into nucleus GO:0042306 78 0.075
cellular ion homeostasis GO:0006873 168 0.074
deoxyribose phosphate metabolic process GO:0019692 6 0.074
cell substrate adhesion GO:0031589 132 0.074
regulation of mrna stability GO:0043488 23 0.073
lipid transport GO:0006869 90 0.073
behavior GO:0007610 112 0.073
Mouse
regulation of protein targeting GO:1903533 91 0.071
protein oligomerization GO:0051259 173 0.071
nucleotide biosynthetic process GO:0009165 109 0.071
negative regulation of reactive oxygen species biosynthetic process GO:1903427 1 0.070
regulation of cellular component biogenesis GO:0044087 281 0.070
response to abiotic stimulus GO:0009628 336 0.070
negative regulation of phosphorus metabolic process GO:0010563 267 0.069
positive regulation of stress activated mapk cascade GO:0032874 60 0.069
response to interleukin 1 GO:0070555 47 0.069
regulation of astrocyte differentiation GO:0048710 3 0.068
response to transition metal nanoparticle GO:1990267 29 0.068
intracellular receptor signaling pathway GO:0030522 104 0.067
regulation of protein localization GO:0032880 296 0.065
positive regulation of nitric oxide biosynthetic process GO:0045429 13 0.065
mitotic cell cycle GO:0000278 326 0.065
regulation of autophagy GO:0010506 52 0.063
positive regulation of interferon gamma production GO:0032729 26 0.063
protein homotetramerization GO:0051289 28 0.062
covalent chromatin modification GO:0016569 254 0.062
multicellular organismal homeostasis GO:0048871 67 0.062
regulation of b cell activation GO:0050864 24 0.061
Mouse
embryo development GO:0009790 123 0.060
cellular response to lipid GO:0071396 127 0.059
intracellular protein transport GO:0006886 270 0.059
detection of biotic stimulus GO:0009595 21 0.059
protein complex disassembly GO:0043241 52 0.059
negative regulation of epithelial cell proliferation GO:0050680 48 0.058
carbohydrate metabolic process GO:0005975 207 0.058
tor signaling GO:0031929 39 0.058
neurotransmitter secretion GO:0007269 4 0.058
regulation of nucleotide metabolic process GO:0006140 269 0.057
response to alcohol GO:0097305 64 0.057
positive regulation of intracellular transport GO:0032388 104 0.056
regulation of lipid transport GO:0032368 44 0.056
protein tetramerization GO:0051262 47 0.056
negative regulation of gliogenesis GO:0014014 3 0.056
response to progesterone GO:0032570 5 0.055
response to peptide GO:1901652 65 0.054
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.054
negative regulation of map kinase activity GO:0043407 27 0.053
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.053
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.053
sterol transport GO:0015918 39 0.052
negative regulation of transport GO:0051051 176 0.052
glycerolipid biosynthetic process GO:0045017 51 0.051
regulation of dna binding GO:0051101 37 0.050
myd88 independent toll like receptor signaling pathway GO:0002756 2 0.050
secretion GO:0046903 254 0.050
cell adhesion GO:0007155 325 0.049
regulation of coagulation GO:0050818 44 0.049
determination of bilateral symmetry GO:0009855 15 0.049
aging GO:0007568 66 0.049
regulation of hemostasis GO:1900046 42 0.049
ubiquitin dependent protein catabolic process GO:0006511 206 0.048
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.048
cell matrix adhesion GO:0007160 85 0.048
regulation of response to biotic stimulus GO:0002831 55 0.046
adaptive immune response GO:0002250 49 0.046
stem cell division GO:0017145 2 0.046
compound eye development GO:0048749 1 0.046
epithelium development GO:0060429 227 0.046
positive regulation of hemostasis GO:1900048 11 0.045
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.045
cellular protein catabolic process GO:0044257 261 0.045
regulation of dna metabolic process GO:0051052 153 0.045
regulation of small gtpase mediated signal transduction GO:0051056 156 0.045
purine deoxyribonucleoside triphosphate metabolic process GO:0009215 4 0.045

TIRAP disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.908
cancer DOID:162 167 0.829
organ system cancer DOID:0050686 164 0.829
retinal disease DOID:5679 118 0.822
retinal degeneration DOID:8466 89 0.822
sensory system disease DOID:0050155 203 0.822
macular degeneration DOID:4448 20 0.822
eye and adnexa disease DOID:1492 150 0.822
nervous system disease DOID:863 431 0.822
eye disease DOID:5614 149 0.822
degeneration of macula and posterior pole DOID:2007 17 0.372
age related macular degeneration DOID:10871 17 0.372
large intestine cancer DOID:5672 29 0.124
gastrointestinal system cancer DOID:3119 52 0.124
intestinal cancer DOID:10155 29 0.124
colorectal cancer DOID:9256 29 0.124
colon cancer DOID:219 25 0.107
immune system cancer DOID:0060083 36 0.058
hematologic cancer DOID:2531 36 0.058
musculoskeletal system disease DOID:17 223 0.045