Homo sapiens

48 known processes

TK1

thymidine kinase 1, soluble

(Aliases: TK2)

TK1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
protein heterotetramerization GO:0051290 3 0.966
regulation of cell cycle GO:0051726 393 0.886
mitotic cell cycle phase transition GO:0044772 162 0.883
cellular response to dna damage stimulus GO:0006974 379 0.864
negative regulation of interleukin 8 secretion GO:2000483 2 0.841
purine containing compound catabolic process GO:0072523 411 0.804
mitotic cell cycle process GO:1903047 286 0.730
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.711
negative regulation of protein maturation GO:1903318 142 0.684
cytokinesis GO:0000910 96 0.624
response to abiotic stimulus GO:0009628 336 0.604
cellular response to glucocorticoid stimulus GO:0071385 4 0.601
negative regulation of protein processing GO:0010955 142 0.551
purine nucleoside triphosphate catabolic process GO:0009146 392 0.534
vasculature development GO:0001944 181 0.471
dna damage checkpoint GO:0000077 68 0.464
regulation of cellular response to stress GO:0080135 244 0.446
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.445
negative regulation of protein metabolic process GO:0051248 391 0.438
nucleoside triphosphate catabolic process GO:0009143 394 0.412
negative regulation of catalytic activity GO:0043086 335 0.385
response to oxygen containing compound GO:1901700 369 0.372
neutrophil clearance GO:0097350 1 0.371
nucleoside monophosphate metabolic process GO:0009123 191 0.370
Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.364
negative regulation of peptidase activity GO:0010466 91 0.359
ribonucleoside monophosphate metabolic process GO:0009161 187 0.359
nucleoside triphosphate metabolic process GO:0009141 422 0.349
cell cycle phase transition GO:0044770 173 0.339
epithelial cell differentiation GO:0030855 141 0.338
ribonucleoside triphosphate catabolic process GO:0009203 391 0.333
dna repair GO:0006281 198 0.330
regulation of mitotic cell cycle GO:0007346 189 0.330
cell division GO:0051301 168 0.324
positive regulation of synaptic transmission GO:0050806 4 0.316
regulation of cell cycle process GO:0010564 266 0.315
purine ribonucleotide catabolic process GO:0009154 404 0.315
mitotic cell cycle GO:0000278 326 0.313
purine nucleoside catabolic process GO:0006152 398 0.309
cellular response to endogenous stimulus GO:0071495 336 0.304
cell morphogenesis GO:0000902 296 0.278
negative regulation of cell cycle GO:0045786 193 0.273
cellular component morphogenesis GO:0032989 314 0.271
nucleoside catabolic process GO:0009164 408 0.270
negative regulation of cell differentiation GO:0045596 171 0.254
purine nucleotide catabolic process GO:0006195 405 0.252
chromosome segregation GO:0007059 114 0.247
negative regulation of multicellular organismal process GO:0051241 317 0.245
nucleoside phosphate catabolic process GO:1901292 412 0.245
negative regulation of protein modification process GO:0031400 200 0.235
nuclear division GO:0000280 128 0.230
multicellular organismal aging GO:0010259 3 0.227
ribonucleoside catabolic process GO:0042454 406 0.223
regulation of protein maturation GO:1903317 150 0.219
regulation of endopeptidase activity GO:0052548 170 0.213
ribonucleotide catabolic process GO:0009261 405 0.212
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.212
regulation of binding GO:0051098 111 0.209
dna biosynthetic process GO:0071897 40 0.209
peptidyl serine phosphorylation GO:0018105 101 0.206
negative regulation of protein secretion GO:0050709 29 0.204
purine ribonucleoside metabolic process GO:0046128 437 0.202
cell cycle g1 s phase transition GO:0044843 80 0.198
organ morphogenesis GO:0009887 147 0.191
negative regulation of proteolysis GO:0045861 132 0.190
neuromuscular junction development GO:0007528 3 0.180
protein processing GO:0016485 226 0.178
negative regulation of hydrolase activity GO:0051346 182 0.177
purine nucleoside triphosphate metabolic process GO:0009144 412 0.174
mapk cascade GO:0000165 288 0.170
response to radiation GO:0009314 151 0.170
response to growth factor GO:0070848 205 0.169
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.168
negative regulation of phosphate metabolic process GO:0045936 267 0.168
ribonucleoside triphosphate metabolic process GO:0009199 412 0.166
actin filament based process GO:0030029 224 0.163
organelle fission GO:0048285 149 0.160
ion homeostasis GO:0050801 230 0.159
nucleotide catabolic process GO:0009166 408 0.155
regulation of mapk cascade GO:0043408 262 0.154
cellular response to growth factor stimulus GO:0071363 197 0.149
negative regulation of cell death GO:0060548 345 0.147
negative regulation of mitotic cell cycle GO:0045930 102 0.146
negative regulation of phosphorylation GO:0042326 174 0.146
glycosyl compound catabolic process GO:1901658 413 0.146
signal transduction in response to dna damage GO:0042770 57 0.145
organophosphate catabolic process GO:0046434 430 0.143
dna dependent dna replication GO:0006261 44 0.142
purine nucleoside monophosphate metabolic process GO:0009126 186 0.141
chromatin modification GO:0016568 298 0.136
regulation of proteolysis GO:0030162 293 0.134
regulation of cell cycle phase transition GO:1901987 126 0.133
atp metabolic process GO:0046034 176 0.132
response to other organism GO:0051707 261 0.132
cellular protein complex assembly GO:0043623 188 0.129
negative regulation of developmental process GO:0051093 247 0.128
negative regulation of phosphorus metabolic process GO:0010563 267 0.126
response to metal ion GO:0010038 84 0.125
cell development GO:0048468 328 0.125
response to inorganic substance GO:0010035 127 0.125
anatomical structure formation involved in morphogenesis GO:0048646 284 0.123
deoxyribose phosphate metabolic process GO:0019692 6 0.122
purine nucleoside monophosphate catabolic process GO:0009128 158 0.122
positive regulation of cellular amine metabolic process GO:0033240 7 0.118
covalent chromatin modification GO:0016569 254 0.116
negative regulation of cell cycle phase transition GO:1901988 89 0.113
viral process GO:0016032 146 0.111
determination of adult lifespan GO:0008340 2 0.111
membrane organization GO:0061024 292 0.111
dna replication GO:0006260 116 0.110
cell morphogenesis involved in differentiation GO:0000904 144 0.105
positive regulation of organelle organization GO:0010638 195 0.101
immune response GO:0006955 307 0.101
positive regulation of cellular catabolic process GO:0031331 284 0.099
protein modification by small protein conjugation GO:0032446 342 0.099
positive regulation of hydrolase activity GO:0051345 331 0.099
regulation of cysteine type endopeptidase activity GO:2000116 127 0.099
myosin filament assembly GO:0031034 2 0.098
positive regulation of transferase activity GO:0051347 227 0.097
positive regulation of transport GO:0051050 336 0.096
regulation of protein processing GO:0070613 150 0.094
response to cytokine GO:0034097 232 0.093
response to organic cyclic compound GO:0014070 204 0.092
dna integrity checkpoint GO:0031570 71 0.089
positive regulation of catabolic process GO:0009896 310 0.087
response to light stimulus GO:0009416 87 0.086
protein catabolic process GO:0030163 325 0.082
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.082
double strand break repair GO:0006302 101 0.081
response to uv GO:0009411 73 0.081
post embryonic development GO:0009791 2 0.080
negative regulation of programmed cell death GO:0043069 321 0.080
cellular amino acid metabolic process GO:0006520 116 0.080
regulation of cell cycle g1 s phase transition GO:1902806 42 0.077
dna recombination GO:0006310 77 0.076
negative regulation of organelle organization GO:0010639 126 0.076
regulation of mitosis GO:0007088 63 0.074
cellular macromolecular complex assembly GO:0034622 324 0.074
response to biotic stimulus GO:0009607 276 0.074
striated muscle myosin thick filament assembly GO:0071688 2 0.073
ribonucleoside monophosphate catabolic process GO:0009158 158 0.073
posttranscriptional regulation of gene expression GO:0010608 213 0.071
dna conformation change GO:0071103 113 0.069
response to alcohol GO:0097305 64 0.066
developmental process involved in reproduction GO:0003006 66 0.065
regulation of gtpase activity GO:0043087 180 0.064
epithelium development GO:0060429 227 0.063
single organism membrane organization GO:0044802 268 0.063
small gtpase mediated signal transduction GO:0007264 78 0.063
meiotic chromosome separation GO:0051307 3 0.062
cellular homeostasis GO:0019725 196 0.062
regulation of nuclear division GO:0051783 65 0.062
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.061
g2 dna damage checkpoint GO:0031572 26 0.061
histone modification GO:0016570 251 0.060
negative regulation of cellular protein metabolic process GO:0032269 353 0.060
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.059
stress activated mapk cascade GO:0051403 93 0.059
protein tetramerization GO:0051262 47 0.056
negative regulation of kinase activity GO:0033673 106 0.056
autophagic cell death GO:0048102 3 0.056
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.055
negative regulation of chromosome organization GO:2001251 48 0.055
regulation of kinase activity GO:0043549 314 0.055
nucleoside monophosphate catabolic process GO:0009125 159 0.054
response to external biotic stimulus GO:0043207 261 0.054
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.053
viral life cycle GO:0019058 132 0.053
positive regulation of nucleotide catabolic process GO:0030813 185 0.053
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.053
vesicle mediated transport GO:0016192 371 0.051
defense response to other organism GO:0098542 129 0.051
circulatory system development GO:0072359 262 0.051
myosin filament organization GO:0031033 2 0.050
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.048
endocytosis GO:0006897 159 0.048
positive regulation of nucleotide metabolic process GO:0045981 230 0.048
cellular chemical homeostasis GO:0055082 180 0.048
regulation of transferase activity GO:0051338 355 0.047
peptidyl serine modification GO:0018209 106 0.046
regulation of nucleotide catabolic process GO:0030811 205 0.044
establishment of organelle localization GO:0051656 59 0.044
neuron projection morphogenesis GO:0048812 50 0.043
cofactor biosynthetic process GO:0051188 31 0.043
organelle assembly GO:0070925 176 0.042
aging GO:0007568 66 0.041
negative regulation of secretion by cell GO:1903531 52 0.041
regulation of cell division GO:0051302 116 0.041
negative regulation of endopeptidase activity GO:0010951 84 0.041
neuron differentiation GO:0030182 138 0.039
regulation of cell activation GO:0050865 125 0.039
immune system development GO:0002520 195 0.037
signal transduction by phosphorylation GO:0023014 297 0.036
cell aging GO:0007569 52 0.036
dna packaging GO:0006323 77 0.035
blood vessel development GO:0001568 172 0.035
response to hypoxia GO:0001666 96 0.035
regulation of protein acetylation GO:1901983 25 0.033
fatty acid metabolic process GO:0006631 115 0.033
gtp catabolic process GO:0006184 237 0.033
mismatch repair GO:0006298 15 0.033
protein oligomerization GO:0051259 173 0.032
regulation of nucleotide metabolic process GO:0006140 269 0.032
hemopoiesis GO:0030097 180 0.032
cell cycle checkpoint GO:0000075 117 0.032
mitotic sister chromatid segregation GO:0000070 53 0.032
positive regulation of protein phosphorylation GO:0001934 313 0.032
cellular divalent inorganic cation homeostasis GO:0072503 128 0.031
negative regulation of cellular component organization GO:0051129 235 0.031
guanosine containing compound metabolic process GO:1901068 244 0.030
cell type specific apoptotic process GO:0097285 125 0.030
cell adhesion GO:0007155 325 0.030
blood vessel morphogenesis GO:0048514 162 0.030
dna duplex unwinding GO:0032508 30 0.029
regulation of chromatin modification GO:1903308 51 0.029
cardiovascular system development GO:0072358 262 0.029
regulation of chromosome segregation GO:0051983 44 0.029
regulation of cytokine production GO:0001817 232 0.028
regulation of gene expression epigenetic GO:0040029 73 0.028
microtubule cytoskeleton organization GO:0000226 176 0.028
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.027
maintenance of location GO:0051235 112 0.027
amine metabolic process GO:0009308 44 0.027
positive regulation of vesicle fusion GO:0031340 4 0.027
nucleotide biosynthetic process GO:0009165 109 0.027
sister chromatid segregation GO:0000819 54 0.027
cellular response to hormone stimulus GO:0032870 125 0.026
female gamete generation GO:0007292 2 0.026
reproductive structure development GO:0048608 55 0.026
osteoclast development GO:0036035 2 0.026
anatomical structure homeostasis GO:0060249 100 0.025
negative regulation of transferase activity GO:0051348 124 0.025
reproductive process GO:0022414 106 0.025
wnt signaling pathway GO:0016055 156 0.025
stem cell development GO:0048864 69 0.024
multi organism cellular process GO:0044764 156 0.024
generation of neurons GO:0048699 152 0.024
positive regulation of lymphocyte activation GO:0051251 73 0.023
endomembrane system organization GO:0010256 196 0.023
meiosis i GO:0007127 4 0.023
organophosphate biosynthetic process GO:0090407 163 0.022
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.022
regulation of cell growth GO:0001558 135 0.022
regulation of nucleoside metabolic process GO:0009118 209 0.022
reproductive system development GO:0061458 56 0.022
negative regulation of response to dna damage stimulus GO:2001021 33 0.022
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.022
neurogenesis GO:0022008 169 0.021
regulation of double strand break repair GO:2000779 22 0.021
atp catabolic process GO:0006200 157 0.021
medium chain fatty acid metabolic process GO:0051791 4 0.021
modification dependent macromolecule catabolic process GO:0043632 212 0.021
atp dependent chromatin remodeling GO:0043044 25 0.021
regulation of dna replication GO:0006275 68 0.020
mitotic cytokinesis GO:0000281 19 0.020
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.020
angiogenesis GO:0001525 147 0.020
regulation of protein serine threonine kinase activity GO:0071900 179 0.020
sex differentiation GO:0007548 45 0.020
nuclear transport GO:0051169 179 0.020
chromosome separation GO:0051304 23 0.020
cell cycle g2 m phase transition GO:0044839 43 0.019
2 deoxyribonucleotide metabolic process GO:0009394 6 0.019
chromatin organization GO:0006325 351 0.019
cellular response to steroid hormone stimulus GO:0071383 37 0.019
cellular response to oxygen containing compound GO:1901701 276 0.019
negative regulation of nervous system development GO:0051961 28 0.019
response to hormone GO:0009725 175 0.018
protein ubiquitination GO:0016567 314 0.018
meiotic cell cycle GO:0051321 13 0.018
regulation of peptidase activity GO:0052547 180 0.018
regulation of stress activated mapk cascade GO:0032872 84 0.018
phagocytosis GO:0006909 42 0.018
double strand break repair via homologous recombination GO:0000724 50 0.018
positive regulation of endopeptidase activity GO:0010950 84 0.018
lymphocyte activation GO:0046649 133 0.018
positive regulation of cellular component organization GO:0051130 376 0.018
neuron projection development GO:0031175 106 0.018
positive regulation of cell cycle process GO:0090068 106 0.017
cell activation GO:0001775 213 0.017
regulation of purine nucleotide metabolic process GO:1900542 264 0.017
negative regulation of cell cycle process GO:0010948 121 0.017
regulation of purine nucleotide catabolic process GO:0033121 205 0.017
chemical homeostasis GO:0048878 306 0.016
nervous system development GO:0007399 293 0.016
cytokine secretion GO:0050663 64 0.016
stress activated protein kinase signaling cascade GO:0031098 94 0.016
nuclear import GO:0051170 106 0.016
response to extracellular stimulus GO:0009991 85 0.016
regulation of vesicle fusion GO:0031338 5 0.015
deoxyribonucleotide metabolic process GO:0009262 6 0.015
gtp metabolic process GO:0046039 239 0.015
actomyosin contractile ring organization GO:0044837 1 0.015
protein dna complex subunit organization GO:0071824 80 0.015
negative regulation of cell proliferation GO:0008285 228 0.015
dephosphorylation GO:0016311 209 0.015
microtubule based process GO:0007017 210 0.015
single organism reproductive process GO:0044702 98 0.015
intracellular transport of virus GO:0075733 14 0.015
response to nutrient GO:0007584 20 0.015
chromatin remodeling GO:0006338 55 0.014
ras protein signal transduction GO:0007265 73 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.014
regulation of immune response GO:0050776 201 0.014
regulation of wnt signaling pathway GO:0030111 123 0.014
mitotic nuclear division GO:0007067 119 0.014
regulation of cellular amine metabolic process GO:0033238 11 0.014
muscle structure development GO:0061061 98 0.014
positive regulation of exit from mitosis GO:0031536 2 0.013
mitotic dna damage checkpoint GO:0044773 28 0.013
response to organonitrogen compound GO:0010243 156 0.013
negative regulation of protein phosphorylation GO:0001933 140 0.013
dna unwinding involved in dna replication GO:0006268 2 0.013
interspecies interaction between organisms GO:0044419 156 0.013
regulation of protein catabolic process GO:0042176 155 0.013
mitotic dna integrity checkpoint GO:0044774 30 0.013
negative regulation of chromatin modification GO:1903309 21 0.013
regulation of response to dna damage stimulus GO:2001020 94 0.013
cytokine mediated signaling pathway GO:0019221 109 0.013
regulation of intrinsic apoptotic signaling pathway in response to dna damage GO:1902229 20 0.013
rna interference GO:0016246 4 0.013
cellular response to organonitrogen compound GO:0071417 124 0.012
negative regulation of mapk cascade GO:0043409 56 0.012
protein targeting GO:0006605 187 0.012
reciprocal dna recombination GO:0035825 4 0.012
regulation of reactive oxygen species metabolic process GO:2000377 41 0.012
regulation of cellular amino acid metabolic process GO:0006521 6 0.012
reproduction GO:0000003 63 0.012
regulation of protein binding GO:0043393 66 0.012
negative regulation of phosphatase activity GO:0010923 61 0.012
protein maturation GO:0051604 233 0.012
negative regulation of protein kinase activity GO:0006469 98 0.011
locomotory behavior GO:0007626 1 0.011
regulation of atp catabolic process GO:1903289 25 0.011
regulation of phosphatase activity GO:0010921 81 0.011
morphogenesis of an epithelium GO:0002009 60 0.011
positive regulation of chromosome organization GO:2001252 41 0.011
spindle organization GO:0007051 53 0.011
response to virus GO:0009615 126 0.011
retina development in camera type eye GO:0060041 15 0.011
single organism cellular localization GO:1902580 332 0.011
cell projection organization GO:0030030 252 0.011
positive regulation of cell cycle GO:0045787 140 0.011
posttranscriptional gene silencing GO:0016441 25 0.011
meiotic chromosome segregation GO:0045132 4 0.011
regulation of mitotic sister chromatid segregation GO:0033047 27 0.011
negative regulation of protein complex assembly GO:0031333 43 0.011
negative regulation of binding GO:0051100 57 0.011
mesenchymal cell differentiation GO:0048762 52 0.010
skeletal myofibril assembly GO:0014866 3 0.010
negative regulation of catabolic process GO:0009895 104 0.010
cell part morphogenesis GO:0032990 137 0.010
macromolecule methylation GO:0043414 97 0.010

TK1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.166
neurodegenerative disease DOID:1289 102 0.166
nervous system disease DOID:863 431 0.166