|
|
i kappab kinase nf kappab signaling
|
GO:0007249 |
166 |
0.834
|
Human |
|
|
positive regulation of extrinsic apoptotic signaling pathway
|
GO:2001238 |
26 |
0.792
|
Human |
|
|
regulation of proteolysis
|
GO:0030162 |
293 |
0.640
|
Human |
|
|
activation of nf kappab inducing kinase activity
|
GO:0007250 |
9 |
0.569
|
|
|
|
negative regulation of transcription from rna polymerase ii promoter
|
GO:0000122 |
281 |
0.563
|
|
|
|
positive regulation of cytokine production
|
GO:0001819 |
167 |
0.506
|
Human Mouse |
|
|
mapk cascade
|
GO:0000165 |
288 |
0.503
|
Human |
|
|
positive regulation of protein serine threonine kinase activity
|
GO:0071902 |
119 |
0.502
|
Human |
|
|
lymphocyte mediated immunity
|
GO:0002449 |
48 |
0.489
|
|
|
|
osteoclast differentiation
|
GO:0030316 |
21 |
0.487
|
Human |
|
|
cdc42 protein signal transduction
|
GO:0032488 |
4 |
0.483
|
|
|
|
positive regulation of sequence specific dna binding transcription factor activity
|
GO:0051091 |
131 |
0.479
|
Human |
|
|
tnfsf11 mediated signaling pathway
|
GO:0071847 |
2 |
0.442
|
Human |
|
|
positive regulation of stress activated mapk cascade
|
GO:0032874 |
60 |
0.430
|
Human |
|
|
regulation of extrinsic apoptotic signaling pathway
|
GO:2001236 |
85 |
0.417
|
Human |
|
|
regulation of osteoclast differentiation
|
GO:0045670 |
18 |
0.417
|
|
|
|
cytokine mediated signaling pathway
|
GO:0019221 |
109 |
0.416
|
Human |
|
|
protein polyubiquitination
|
GO:0000209 |
110 |
0.403
|
|
|
|
positive regulation of endothelial cell apoptotic process
|
GO:2000353 |
8 |
0.398
|
Human |
|
|
hemopoiesis
|
GO:0030097 |
180 |
0.376
|
Human |
|
|
positive regulation of map kinase activity
|
GO:0043406 |
80 |
0.365
|
Human |
|
|
cellular response to tumor necrosis factor
|
GO:0071356 |
63 |
0.356
|
Human |
|
|
regulation of map kinase activity
|
GO:0043405 |
108 |
0.345
|
Human |
|
|
regulation of i kappab kinase nf kappab signaling
|
GO:0043122 |
162 |
0.341
|
Human |
|
|
regulation of jnk cascade
|
GO:0046328 |
73 |
0.323
|
Human |
|
|
regulation of protein serine threonine kinase activity
|
GO:0071900 |
179 |
0.319
|
Human |
|
|
protein autoubiquitination
|
GO:0051865 |
37 |
0.317
|
|
|
|
positive regulation of programmed cell death
|
GO:0043068 |
249 |
0.317
|
Human |
|
|
positive regulation of osteoclast differentiation
|
GO:0045672 |
9 |
0.294
|
|
|
|
signal transduction by phosphorylation
|
GO:0023014 |
297 |
0.288
|
Human |
|
|
positive regulation of nf kappab transcription factor activity
|
GO:0051092 |
81 |
0.287
|
Human |
|
|
regulation of cdc42 protein signal transduction
|
GO:0032489 |
14 |
0.280
|
Human |
|
|
regulation of secretion
|
GO:0051046 |
194 |
0.279
|
Mouse |
|
|
erk1 and erk2 cascade
|
GO:0070371 |
104 |
0.275
|
Human |
|
|
positive regulation of protein kinase activity
|
GO:0045860 |
190 |
0.275
|
Human |
|
|
positive regulation of mapk cascade
|
GO:0043410 |
190 |
0.268
|
Human |
|
|
positive regulation of i kappab kinase nf kappab signaling
|
GO:0043123 |
132 |
0.268
|
Human |
|
|
t cell cytokine production
|
GO:0002369 |
12 |
0.267
|
|
|
|
apoptotic signaling pathway
|
GO:0097190 |
268 |
0.267
|
Human |
|
|
adaptive immune response
|
GO:0002250 |
49 |
0.265
|
Human |
|
|
activation of protein kinase activity
|
GO:0032147 |
90 |
0.259
|
|
|
|
extrinsic apoptotic signaling pathway
|
GO:0097191 |
119 |
0.257
|
Human |
|
|
cellular response to external stimulus
|
GO:0071496 |
111 |
0.256
|
Human |
|
|
cytokine production
|
GO:0001816 |
247 |
0.253
|
Human Mouse |
|
|
activation of immune response
|
GO:0002253 |
114 |
0.251
|
|
|
|
cellular response to cytokine stimulus
|
GO:0071345 |
181 |
0.244
|
Human |
|
|
negative regulation of peptidase activity
|
GO:0010466 |
91 |
0.234
|
|
|
|
regulation of lymphocyte mediated immunity
|
GO:0002706 |
33 |
0.232
|
|
|
|
response to bacterium
|
GO:0009617 |
144 |
0.228
|
Human Mouse |
|
|
guanosine containing compound metabolic process
|
GO:1901068 |
244 |
0.228
|
Human |
|
|
positive regulation of immune system process
|
GO:0002684 |
283 |
0.227
|
Mouse |
|
|
positive regulation of transferase activity
|
GO:0051347 |
227 |
0.224
|
Human |
|
|
cellular ketone metabolic process
|
GO:0042180 |
80 |
0.223
|
|
|
|
immune effector process
|
GO:0002252 |
159 |
0.221
|
Mouse |
|
|
positive regulation of apoptotic signaling pathway
|
GO:2001235 |
70 |
0.214
|
Human |
|
|
regulation of kinase activity
|
GO:0043549 |
314 |
0.213
|
Human |
|
|
regulation of erk1 and erk2 cascade
|
GO:0070372 |
99 |
0.212
|
Human |
|
|
response to tumor necrosis factor
|
GO:0034612 |
76 |
0.207
|
Human |
|
|
regulation of jun kinase activity
|
GO:0043506 |
27 |
0.205
|
Human |
|
|
negative regulation of neurological system process
|
GO:0031645 |
2 |
0.204
|
Human |
|
|
leukocyte differentiation
|
GO:0002521 |
98 |
0.203
|
Human |
|
|
positive regulation of immune response
|
GO:0050778 |
159 |
0.201
|
Mouse |
|
|
positive regulation of nik nf kappab signaling
|
GO:1901224 |
10 |
0.200
|
|
|
|
regulation of leukocyte mediated immunity
|
GO:0002703 |
38 |
0.195
|
|
|
|
small gtpase mediated signal transduction
|
GO:0007264 |
78 |
0.195
|
|
|
|
regulation of mapk cascade
|
GO:0043408 |
262 |
0.192
|
Human |
|
|
nik nf kappab signaling
|
GO:0038061 |
12 |
0.191
|
|
|
|
regulation of cytokine production
|
GO:0001817 |
232 |
0.190
|
Human Mouse |
|
|
rho protein signal transduction
|
GO:0007266 |
26 |
0.188
|
|
|
|
regulation of nik nf kappab signaling
|
GO:1901222 |
11 |
0.188
|
|
|
|
regulation of t cell cytokine production
|
GO:0002724 |
10 |
0.186
|
|
|
|
regulation of complement activation lectin pathway
|
GO:0001868 |
2 |
0.182
|
|
|
|
regulation of adaptive immune response
|
GO:0002819 |
33 |
0.182
|
|
|
|
positive regulation of phosphorylation
|
GO:0042327 |
394 |
0.182
|
Human Mouse |
|
|
immune response regulating signaling pathway
|
GO:0002764 |
97 |
0.175
|
|
|
|
regulation of cell differentiation
|
GO:0045595 |
393 |
0.170
|
|
|
|
positive regulation of leukocyte mediated immunity
|
GO:0002705 |
24 |
0.163
|
|
|
|
regulation of transferase activity
|
GO:0051338 |
355 |
0.161
|
Human |
|
|
production of molecular mediator of immune response
|
GO:0002440 |
37 |
0.155
|
Mouse |
|
|
positive regulation of myeloid leukocyte differentiation
|
GO:0002763 |
24 |
0.154
|
|
|
|
cellular response to lipopolysaccharide
|
GO:0071222 |
57 |
0.154
|
Human |
|
|
jnk cascade
|
GO:0007254 |
80 |
0.145
|
Human |
|
|
regulation of endothelial cell apoptotic process
|
GO:2000351 |
24 |
0.143
|
Human |
|
|
myeloid leukocyte differentiation
|
GO:0002573 |
60 |
0.143
|
Human |
|
|
positive regulation of protein binding
|
GO:0032092 |
24 |
0.143
|
|
|
|
positive regulation of developmental process
|
GO:0051094 |
314 |
0.143
|
|
|
|
immune response activating signal transduction
|
GO:0002757 |
90 |
0.140
|
|
|
|
regulation of production of molecular mediator of immune response
|
GO:0002700 |
25 |
0.138
|
Mouse |
|
|
regulation of cellular response to stress
|
GO:0080135 |
244 |
0.137
|
Human |
|
|
purine nucleotide catabolic process
|
GO:0006195 |
405 |
0.136
|
Human |
|
|
regulation of sequence specific dna binding transcription factor activity
|
GO:0051090 |
211 |
0.133
|
Human |
|
|
response to cytokine
|
GO:0034097 |
232 |
0.132
|
Human |
|
|
leukocyte mediated immunity
|
GO:0002443 |
59 |
0.130
|
|
|
|
regulation of immune response
|
GO:0050776 |
201 |
0.130
|
Mouse |
|
|
positive regulation of protein phosphorylation
|
GO:0001934 |
313 |
0.129
|
Human Mouse |
|
|
regulation of peptidase activity
|
GO:0052547 |
180 |
0.127
|
|
|
|
immune response
|
GO:0006955 |
307 |
0.126
|
Human Mouse |
|
|
regulation of protein binding
|
GO:0043393 |
66 |
0.126
|
|
|
|
positive regulation of erk1 and erk2 cascade via tnfsf11 mediated signaling
|
GO:0071848 |
2 |
0.122
|
Human |
|
|
negative regulation of complement activation lectin pathway
|
GO:0001869 |
2 |
0.121
|
|
|
|
immune response activating cell surface receptor signaling pathway
|
GO:0002429 |
45 |
0.120
|
|
|
|
regulation of protein transport
|
GO:0051223 |
213 |
0.119
|
Mouse |
|
|
cellular response to biotic stimulus
|
GO:0071216 |
71 |
0.119
|
Human |
|
|
positive regulation of transcription regulatory region dna binding
|
GO:2000679 |
8 |
0.119
|
|
|
|
nucleoside triphosphate metabolic process
|
GO:0009141 |
422 |
0.118
|
Human |
|
|
protein homooligomerization
|
GO:0051260 |
100 |
0.116
|
|
|
|
positive regulation of cell differentiation
|
GO:0045597 |
211 |
0.116
|
|
|
|
tumor necrosis factor mediated signaling pathway
|
GO:0033209 |
27 |
0.112
|
Human |
|
|
hematopoietic or lymphoid organ development
|
GO:0048534 |
186 |
0.112
|
Human |
|
|
regulation of endopeptidase activity
|
GO:0052548 |
170 |
0.112
|
|
|
|
positive regulation of proteolysis
|
GO:0045862 |
142 |
0.112
|
Human |
|
|
nucleotide catabolic process
|
GO:0009166 |
408 |
0.111
|
Human |
|
|
glycosyl compound catabolic process
|
GO:1901658 |
413 |
0.111
|
Human |
|
|
myeloid cell differentiation
|
GO:0030099 |
117 |
0.110
|
Human |
|
|
response to lipid
|
GO:0033993 |
206 |
0.110
|
Human |
|
|
regulation of protein kinase activity
|
GO:0045859 |
289 |
0.110
|
Human |
|
|
multicellular organismal homeostasis
|
GO:0048871 |
67 |
0.109
|
|
|
|
positive regulation of ras gtpase activity
|
GO:0032320 |
117 |
0.108
|
Human |
|
|
protein k63 linked ubiquitination
|
GO:0070534 |
31 |
0.107
|
|
|
|
cytokine production involved in immune response
|
GO:0002367 |
27 |
0.106
|
Mouse |
|
|
negative regulation of developmental process
|
GO:0051093 |
247 |
0.105
|
Human |
|
|
protein oligomerization
|
GO:0051259 |
173 |
0.102
|
|
|
|
regulation of binding
|
GO:0051098 |
111 |
0.102
|
|
|
|
regulation of stress activated protein kinase signaling cascade
|
GO:0070302 |
85 |
0.102
|
Human |
|
|
positive regulation of jnk cascade
|
GO:0046330 |
52 |
0.101
|
Human |
|
|
negative regulation of endopeptidase activity
|
GO:0010951 |
84 |
0.101
|
|
|
|
interleukin 2 production
|
GO:0032623 |
20 |
0.100
|
|
|
|
positive regulation of kinase activity
|
GO:0033674 |
204 |
0.100
|
Human |
|
|
protein trimerization
|
GO:0070206 |
20 |
0.099
|
|
|
|
response to other organism
|
GO:0051707 |
261 |
0.098
|
Human Mouse |
|
|
stress activated protein kinase signaling cascade
|
GO:0031098 |
94 |
0.097
|
Human |
|
|
protein ubiquitination
|
GO:0016567 |
314 |
0.097
|
|
|
|
protein homotrimerization
|
GO:0070207 |
9 |
0.097
|
|
|
|
positive regulation of stress activated protein kinase signaling cascade
|
GO:0070304 |
61 |
0.097
|
Human |
|
|
enzyme linked receptor protein signaling pathway
|
GO:0007167 |
303 |
0.096
|
|
|
|
regulation of protein homodimerization activity
|
GO:0043496 |
9 |
0.095
|
|
|
|
regulation of transcription regulatory region dna binding
|
GO:2000677 |
15 |
0.095
|
|
|
|
positive regulation of t cell cytokine production
|
GO:0002726 |
4 |
0.095
|
|
|
|
cell adhesion
|
GO:0007155 |
325 |
0.094
|
|
|
|
regulation of protein maturation
|
GO:1903317 |
150 |
0.094
|
|
|
|
response to mechanical stimulus
|
GO:0009612 |
51 |
0.093
|
Human |
|
|
regulation of ras protein signal transduction
|
GO:0046578 |
155 |
0.093
|
Human |
|
|
response to external biotic stimulus
|
GO:0043207 |
261 |
0.092
|
Human Mouse |
|
|
regulation of small gtpase mediated signal transduction
|
GO:0051056 |
156 |
0.091
|
Human |
|
|
positive regulation of myeloid cell differentiation
|
GO:0045639 |
39 |
0.090
|
|
|
|
cellular response to molecule of bacterial origin
|
GO:0071219 |
62 |
0.090
|
Human |
|
|
immune response regulating cell surface receptor signaling pathway
|
GO:0002768 |
51 |
0.090
|
|
|
|
t cell receptor signaling pathway
|
GO:0050852 |
21 |
0.088
|
|
|
|
neuronal action potential
|
GO:0019228 |
9 |
0.088
|
|
|
|
antigen receptor mediated signaling pathway
|
GO:0050851 |
38 |
0.088
|
|
|
|
cellular response to abiotic stimulus
|
GO:0071214 |
117 |
0.088
|
Human |
|
|
cellular cation homeostasis
|
GO:0030003 |
163 |
0.087
|
Human |
|
|
leukocyte activation
|
GO:0045321 |
164 |
0.087
|
Mouse |
|
|
positive regulation of cellular catabolic process
|
GO:0031331 |
284 |
0.086
|
Human |
|
|
positive regulation of apoptotic process
|
GO:0043065 |
246 |
0.086
|
Human |
|
|
positive regulation of gtpase activity
|
GO:0043547 |
166 |
0.085
|
Human |
|
|
release of cytoplasmic sequestered nf kappab
|
GO:0008588 |
4 |
0.085
|
|
|
|
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002822 |
29 |
0.085
|
|
|
|
cellular response to oxygen containing compound
|
GO:1901701 |
276 |
0.083
|
Human |
|
|
regulation of immune effector process
|
GO:0002697 |
91 |
0.083
|
Mouse |
|
|
negative regulation of proteolysis
|
GO:0045861 |
132 |
0.083
|
|
|
|
negative regulation of multicellular organismal process
|
GO:0051241 |
317 |
0.081
|
Human |
|
|
response to interleukin 1
|
GO:0070555 |
47 |
0.081
|
|
|
|
negative regulation of protein maturation
|
GO:1903318 |
142 |
0.081
|
|
|
|
positive regulation of interleukin 2 production
|
GO:0032743 |
11 |
0.081
|
|
|
|
ribonucleoside triphosphate metabolic process
|
GO:0009199 |
412 |
0.079
|
Human |
|
|
regulation of stress activated mapk cascade
|
GO:0032872 |
84 |
0.079
|
Human |
|
|
regulation of myeloid cell differentiation
|
GO:0045637 |
81 |
0.077
|
|
|
|
protein processing
|
GO:0016485 |
226 |
0.073
|
|
|
|
regulation of cellular amine metabolic process
|
GO:0033238 |
11 |
0.073
|
|
|
|
secretion by cell
|
GO:0032940 |
226 |
0.073
|
Mouse |
|
|
immune system development
|
GO:0002520 |
195 |
0.073
|
Human |
|
|
action potential
|
GO:0001508 |
34 |
0.072
|
|
|
|
negative regulation of sequence specific dna binding transcription factor activity
|
GO:0043433 |
89 |
0.071
|
|
|
|
t cell mediated immunity
|
GO:0002456 |
25 |
0.070
|
|
|
|
regulation of establishment of protein localization
|
GO:0070201 |
242 |
0.069
|
Mouse |
|
|
negative regulation of catalytic activity
|
GO:0043086 |
335 |
0.069
|
|
|
|
regulation of leukocyte activation
|
GO:0002694 |
115 |
0.067
|
Mouse |
|
|
positive regulation of binding
|
GO:0051099 |
45 |
0.066
|
|
|
|
cell type specific apoptotic process
|
GO:0097285 |
125 |
0.066
|
Human |
|
|
response to oxygen containing compound
|
GO:1901700 |
369 |
0.066
|
Human |
|
|
regulation of protein processing
|
GO:0070613 |
150 |
0.065
|
|
|
|
positive regulation of catabolic process
|
GO:0009896 |
310 |
0.065
|
Human |
|
|
regulation of cell activation
|
GO:0050865 |
125 |
0.065
|
Mouse |
|
|
positive regulation of leukocyte differentiation
|
GO:1902107 |
37 |
0.065
|
|
|
|
cellular amino acid metabolic process
|
GO:0006520 |
116 |
0.064
|
|
|
|
positive regulation of protein catabolic process
|
GO:0045732 |
75 |
0.063
|
Human |
|
|
response to lipopolysaccharide
|
GO:0032496 |
70 |
0.062
|
Human |
|
|
protein maturation
|
GO:0051604 |
233 |
0.062
|
|
|
|
positive regulation of jun kinase activity
|
GO:0043507 |
23 |
0.061
|
Human |
|
|
positive regulation of immune effector process
|
GO:0002699 |
40 |
0.061
|
Mouse |
|
|
purine ribonucleotide catabolic process
|
GO:0009154 |
404 |
0.061
|
Human |
|
|
organophosphate catabolic process
|
GO:0046434 |
430 |
0.061
|
Human |
|
|
response to nitric oxide
|
GO:0071731 |
4 |
0.060
|
|
|
|
negative regulation of cellular protein metabolic process
|
GO:0032269 |
353 |
0.060
|
|
|
|
positive regulation of rho gtpase activity
|
GO:0032321 |
56 |
0.060
|
Human |
|
|
ras protein signal transduction
|
GO:0007265 |
73 |
0.059
|
|
|
|
positive regulation of organelle organization
|
GO:0010638 |
195 |
0.059
|
|
|
|
purine ribonucleoside triphosphate catabolic process
|
GO:0009207 |
391 |
0.059
|
Human |
|
|
regulation of myeloid leukocyte differentiation
|
GO:0002761 |
39 |
0.059
|
|
|
|
guanosine containing compound catabolic process
|
GO:1901069 |
239 |
0.059
|
Human |
|
|
regulation of protein localization
|
GO:0032880 |
296 |
0.058
|
Mouse |
|
|
negative regulation of protein processing
|
GO:0010955 |
142 |
0.058
|
|
|
|
positive regulation of cellular amino acid metabolic process
|
GO:0045764 |
3 |
0.058
|
|
|
|
regulation of response to external stimulus
|
GO:0032101 |
222 |
0.056
|
|
|
|
ribonucleotide catabolic process
|
GO:0009261 |
405 |
0.055
|
Human |
|
|
negative regulation of nf kappab transcription factor activity
|
GO:0032088 |
51 |
0.054
|
|
|
|
negative regulation of hydrolase activity
|
GO:0051346 |
182 |
0.054
|
|
|
|
positive regulation of cell proliferation
|
GO:0008284 |
301 |
0.054
|
|
|
|
positive regulation of adaptive immune response
|
GO:0002821 |
21 |
0.053
|
|
|
|
cellular response to lipid
|
GO:0071396 |
127 |
0.053
|
Human |
|
|
regulation of cytokine production involved in immune response
|
GO:0002718 |
22 |
0.053
|
Mouse |
|
|
regulation of lymphocyte activation
|
GO:0051249 |
103 |
0.052
|
Mouse |
|
|
purine ribonucleoside triphosphate metabolic process
|
GO:0009205 |
411 |
0.052
|
Human |
|
|
lymphocyte activation
|
GO:0046649 |
133 |
0.052
|
Mouse |
|
|
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002460 |
40 |
0.051
|
|
|
|
cell activation
|
GO:0001775 |
213 |
0.050
|
Mouse |
|
|
positive regulation of cell activation
|
GO:0050867 |
81 |
0.050
|
|
|
|
positive regulation of lymphocyte activation
|
GO:0051251 |
73 |
0.049
|
|
|
|
response to molecule of bacterial origin
|
GO:0002237 |
82 |
0.049
|
Human |
|
|
positive regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043280 |
69 |
0.048
|
|
|
|
regulation of t cell mediated immunity
|
GO:0002709 |
18 |
0.048
|
|
|
|
anion transport
|
GO:0006820 |
161 |
0.048
|
|
|
|
purine nucleoside triphosphate catabolic process
|
GO:0009146 |
392 |
0.047
|
Human |
|
|
endothelial cell apoptotic process
|
GO:0072577 |
26 |
0.047
|
Human |
|
|
response to biotic stimulus
|
GO:0009607 |
276 |
0.046
|
Human Mouse |
|
|
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
|
GO:0002824 |
19 |
0.046
|
|
|
|
transmission of nerve impulse
|
GO:0019226 |
11 |
0.045
|
|
|
|
positive regulation of gtp catabolic process
|
GO:0033126 |
166 |
0.045
|
Human |
|
|
protein modification by small protein conjugation
|
GO:0032446 |
342 |
0.045
|
|
|
|
positive regulation of lymphocyte mediated immunity
|
GO:0002708 |
23 |
0.043
|
|
|
|
cellular lipid metabolic process
|
GO:0044255 |
303 |
0.043
|
|
|
|
response to abiotic stimulus
|
GO:0009628 |
336 |
0.042
|
Human |
|
|
biological adhesion
|
GO:0022610 |
331 |
0.042
|
|
|
|
anatomical structure homeostasis
|
GO:0060249 |
100 |
0.042
|
|
|
|
positive regulation of dna binding
|
GO:0043388 |
17 |
0.042
|
|
|
|
regulation of cysteine type endopeptidase activity
|
GO:2000116 |
127 |
0.042
|
|
|
|
negative regulation of response to external stimulus
|
GO:0032102 |
83 |
0.042
|
|
|
|
regulation of purine nucleotide metabolic process
|
GO:1900542 |
264 |
0.042
|
Human |
|
|
positive regulation of mitochondrion organization
|
GO:0010822 |
30 |
0.041
|
|
|
|
positive regulation of cellular component organization
|
GO:0051130 |
376 |
0.040
|
|
|
|
positive regulation of hydrolase activity
|
GO:0051345 |
331 |
0.039
|
Human |
|
|
protein secretion
|
GO:0009306 |
98 |
0.038
|
Mouse |
|
|
negative regulation of phosphorus metabolic process
|
GO:0010563 |
267 |
0.037
|
|
|
|
neurological system process
|
GO:0050877 |
163 |
0.037
|
Human |
|
|
positive regulation of cell death
|
GO:0010942 |
263 |
0.036
|
Human |
|
|
stress activated mapk cascade
|
GO:0051403 |
93 |
0.036
|
Human |
|
|
negative regulation of protein metabolic process
|
GO:0051248 |
391 |
0.036
|
|
|
|
vesicle mediated transport
|
GO:0016192 |
371 |
0.036
|
|
|
|
purine nucleoside catabolic process
|
GO:0006152 |
398 |
0.036
|
Human |
|
|
inflammatory response
|
GO:0006954 |
79 |
0.036
|
|
|
|
system process
|
GO:0003008 |
349 |
0.036
|
Human |
|
|
lipid metabolic process
|
GO:0006629 |
381 |
0.035
|
|
|
|
cellular response to dna damage stimulus
|
GO:0006974 |
379 |
0.035
|
|
|
|
leukocyte migration
|
GO:0050900 |
107 |
0.034
|
Mouse |
|
|
positive regulation of purine nucleotide metabolic process
|
GO:1900544 |
227 |
0.033
|
Human |
|
|
positive regulation of cdc42 gtpase activity
|
GO:0043089 |
6 |
0.032
|
Human |
|
|
chemotaxis
|
GO:0006935 |
157 |
0.031
|
|
|
|
positive regulation of t cell mediated immunity
|
GO:0002711 |
12 |
0.030
|
|
|
|
negative regulation of locomotion
|
GO:0040013 |
118 |
0.030
|
|
|
|
regulation of purine nucleotide catabolic process
|
GO:0033121 |
205 |
0.030
|
Human |
|
|
cellular protein complex assembly
|
GO:0043623 |
188 |
0.030
|
|
|
|
single organism cell adhesion
|
GO:0098602 |
179 |
0.030
|
|
|
|
immunoglobulin secretion
|
GO:0048305 |
1 |
0.030
|
|
|
|
regulation of secretion by cell
|
GO:1903530 |
177 |
0.030
|
Mouse |
|
|
defense response
|
GO:0006952 |
315 |
0.029
|
Mouse |
|
|
nucleoside phosphate catabolic process
|
GO:1901292 |
412 |
0.029
|
Human |
|
|
nucleoside triphosphate catabolic process
|
GO:0009143 |
394 |
0.029
|
Human |
|
|
regulation of cytokine biosynthetic process
|
GO:0042035 |
35 |
0.029
|
Human |
|
|
response to growth factor
|
GO:0070848 |
205 |
0.029
|
|
|
|
lymphocyte apoptotic process
|
GO:0070227 |
20 |
0.029
|
|
|
|
multicellular organismal aging
|
GO:0010259 |
3 |
0.029
|
|
|
|
maintenance of location
|
GO:0051235 |
112 |
0.028
|
|
|
|
negative regulation of myelination
|
GO:0031642 |
1 |
0.028
|
Human |
|
|
purine ribonucleoside catabolic process
|
GO:0046130 |
398 |
0.028
|
Human |
|
|
regulation of cytokine secretion
|
GO:0050707 |
57 |
0.027
|
Mouse |
|
|
positive regulation of cytokine biosynthetic process
|
GO:0042108 |
25 |
0.027
|
Human |
|
|
ribonucleoside triphosphate catabolic process
|
GO:0009203 |
391 |
0.027
|
Human |
|
|
regulation of cellular component biogenesis
|
GO:0044087 |
281 |
0.027
|
|
|
|
cellular response to mechanical stimulus
|
GO:0071260 |
39 |
0.027
|
Human |
|
|
transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0007178 |
125 |
0.027
|
|
|
|
regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043281 |
116 |
0.027
|
|
|
|
ribonucleoside catabolic process
|
GO:0042454 |
406 |
0.027
|
Human |
|
|
positive regulation of protein homodimerization activity
|
GO:0090073 |
5 |
0.026
|
|
|
|
regulation of cellular component movement
|
GO:0051270 |
334 |
0.026
|
Mouse |
|
|
amine metabolic process
|
GO:0009308 |
44 |
0.026
|
|
|
|
regulation of anatomical structure morphogenesis
|
GO:0022603 |
286 |
0.026
|
|
|
|
regulation of innate immune response
|
GO:0045088 |
97 |
0.026
|
|
|
|
positive regulation of transport
|
GO:0051050 |
336 |
0.025
|
Mouse |
|
|
nucleoside catabolic process
|
GO:0009164 |
408 |
0.025
|
Human |
|
|
divalent inorganic cation homeostasis
|
GO:0072507 |
136 |
0.025
|
Human |
|
|
regulation of immunoglobulin production
|
GO:0002637 |
4 |
0.025
|
|
|
|
post embryonic development
|
GO:0009791 |
2 |
0.025
|
|
|
|
negative regulation of immune system process
|
GO:0002683 |
136 |
0.025
|
Mouse |
|
|
regulation of defense response
|
GO:0031347 |
154 |
0.024
|
|
|
|
postsynaptic membrane organization
|
GO:0001941 |
2 |
0.024
|
|
|
|
positive regulation of immunoglobulin production
|
GO:0002639 |
4 |
0.024
|
|
|
|
mitochondrion organization
|
GO:0007005 |
156 |
0.024
|
|
|
|
lipid transport
|
GO:0006869 |
90 |
0.024
|
|
|
|
positive regulation of nucleoside metabolic process
|
GO:0045979 |
186 |
0.023
|
Human |
|
|
regulation of cell morphogenesis
|
GO:0022604 |
153 |
0.023
|
|
|
|
positive regulation of immunoglobulin mediated immune response
|
GO:0002891 |
4 |
0.023
|
|
|
|
regulation of rho gtpase activity
|
GO:0032319 |
66 |
0.023
|
Human |
|
|
regulation of apoptotic signaling pathway
|
GO:2001233 |
175 |
0.023
|
Human |
|
|
regulation of mitochondrion organization
|
GO:0010821 |
54 |
0.023
|
|
|
|
negative regulation of vasculature development
|
GO:1901343 |
43 |
0.023
|
|
|
|
negative regulation of response to wounding
|
GO:1903035 |
47 |
0.022
|
|
|
|
negative regulation of cysteine type endopeptidase activity
|
GO:2000117 |
48 |
0.022
|
|
|
|
neuromuscular junction development
|
GO:0007528 |
3 |
0.022
|
|
|
|
single organism cellular localization
|
GO:1902580 |
332 |
0.022
|
|
|
|
metal ion homeostasis
|
GO:0055065 |
169 |
0.022
|
Human |
|
|
maintenance of location in cell
|
GO:0051651 |
62 |
0.021
|
|
|
|
positive regulation of cysteine type endopeptidase activity
|
GO:2001056 |
79 |
0.021
|
|
|
|
negative regulation of phosphate metabolic process
|
GO:0045936 |
267 |
0.021
|
|
|
|
positive regulation of secretion
|
GO:0051047 |
116 |
0.021
|
Mouse |
|
|
negative regulation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0043154 |
46 |
0.021
|
|
|
|
cellular macromolecular complex assembly
|
GO:0034622 |
324 |
0.021
|
|
|
|
positive regulation of protein transport
|
GO:0051222 |
135 |
0.021
|
Mouse |
|
|
negative regulation of protein activation cascade
|
GO:2000258 |
7 |
0.021
|
|
|
|
regulation of nucleotide catabolic process
|
GO:0030811 |
205 |
0.020
|
Human |
|
|
regulation of cellular ketone metabolic process
|
GO:0010565 |
50 |
0.020
|
|
|
|
lipid localization
|
GO:0010876 |
106 |
0.020
|
|
|
|
cellular homeostasis
|
GO:0019725 |
196 |
0.020
|
Human |
|
|
cellular response to transforming growth factor beta stimulus
|
GO:0071560 |
94 |
0.020
|
|
|
|
myeloid leukocyte migration
|
GO:0097529 |
62 |
0.020
|
|
|
|
jak stat cascade
|
GO:0007259 |
46 |
0.020
|
Human |
|
|
regulation of ras gtpase activity
|
GO:0032318 |
128 |
0.020
|
Human |
|
|
regulation of interleukin 2 production
|
GO:0032663 |
19 |
0.020
|
|
|
|
positive regulation of leukocyte activation
|
GO:0002696 |
80 |
0.020
|
|
|
|
regulation of transmembrane receptor protein serine threonine kinase signaling pathway
|
GO:0090092 |
90 |
0.019
|
|
|
|
membrane protein ectodomain proteolysis
|
GO:0006509 |
33 |
0.019
|
Human |
|
|
peptide transport
|
GO:0015833 |
74 |
0.019
|
|
|
|
leukocyte chemotaxis
|
GO:0030595 |
76 |
0.019
|
|
|
|
regulation of membrane protein ectodomain proteolysis
|
GO:0051043 |
17 |
0.019
|
Human |
|
|
negative regulation of protein modification process
|
GO:0031400 |
200 |
0.019
|
|
|
|
positive regulation of release of cytochrome c from mitochondria
|
GO:0090200 |
18 |
0.019
|
|
|
|
cellular macromolecule catabolic process
|
GO:0044265 |
380 |
0.019
|
|
|
|
negative regulation of phosphorylation
|
GO:0042326 |
174 |
0.019
|
|
|
|
negative regulation of protein transport
|
GO:0051224 |
75 |
0.019
|
|
|
|
dephosphorylation
|
GO:0016311 |
209 |
0.018
|
|
|
|
regulation of protein catabolic process
|
GO:0042176 |
155 |
0.018
|
Human |
|
|
stem cell division
|
GO:0017145 |
2 |
0.018
|
|
|
|
nervous system development
|
GO:0007399 |
293 |
0.018
|
Human |
|
|
regulation of nervous system development
|
GO:0051960 |
88 |
0.018
|
Human |
|
|
organic anion transport
|
GO:0015711 |
103 |
0.018
|
|
|
|
negative regulation of cellular amino acid metabolic process
|
GO:0045763 |
2 |
0.018
|
|
|
|
tissue homeostasis
|
GO:0001894 |
63 |
0.018
|
|
|
|
positive regulation of protein secretion
|
GO:0050714 |
60 |
0.018
|
Mouse |
|
|
regulation of vesicle mediated transport
|
GO:0060627 |
130 |
0.018
|
|
|
|
purine ribonucleoside metabolic process
|
GO:0046128 |
437 |
0.018
|
Human |
|
|
programmed necrotic cell death
|
GO:0097300 |
18 |
0.017
|
|
|
|
g protein coupled receptor signaling pathway
|
GO:0007186 |
207 |
0.017
|
|
|
|
secretion
|
GO:0046903 |
254 |
0.017
|
Mouse |
|
|
regulation of protein complex assembly
|
GO:0043254 |
147 |
0.017
|
|
|
|
oogenesis
|
GO:0048477 |
2 |
0.017
|
|
|
|
positive regulation of endopeptidase activity
|
GO:0010950 |
84 |
0.017
|
|
|
|
positive regulation of membrane protein ectodomain proteolysis
|
GO:0051044 |
13 |
0.017
|
Human |
|
|
regulation of lymphocyte proliferation
|
GO:0050670 |
64 |
0.017
|
Mouse |
|
|
negative regulation of defense response
|
GO:0031348 |
47 |
0.017
|
|
|
|
regulation of anion transport
|
GO:0044070 |
25 |
0.017
|
|
|
|
regulation of protein secretion
|
GO:0050708 |
86 |
0.016
|
Mouse |
|
|
posttranscriptional regulation of gene expression
|
GO:0010608 |
213 |
0.016
|
|
|
|
memory
|
GO:0007613 |
3 |
0.016
|
|
|
|
positive regulation of cell adhesion
|
GO:0045785 |
84 |
0.016
|
|
|
|
regulation of interleukin 10 secretion
|
GO:2001179 |
4 |
0.016
|
|
|
|
negative regulation of cell cycle
|
GO:0045786 |
193 |
0.016
|
|
|
|
interleukin 12 secretion
|
GO:0072610 |
1 |
0.016
|
|
|
|
negative regulation of intracellular signal transduction
|
GO:1902532 |
183 |
0.016
|
|
|
|
triglyceride metabolic process
|
GO:0006641 |
23 |
0.016
|
|
|
|
response to wounding
|
GO:0009611 |
168 |
0.016
|
|
|
|
regulation of wound healing
|
GO:0061041 |
56 |
0.016
|
|
|
|
phospholipid metabolic process
|
GO:0006644 |
99 |
0.016
|
|
|
|
positive regulation of rac gtpase activity
|
GO:0032855 |
31 |
0.016
|
Human |
|
|
membrane organization
|
GO:0061024 |
292 |
0.016
|
|
|
|
female gamete generation
|
GO:0007292 |
2 |
0.016
|
|
|
|
cell substrate adhesion
|
GO:0031589 |
132 |
0.016
|
|
|
|
negative regulation of immune response
|
GO:0050777 |
40 |
0.016
|
|
|
|
anatomical structure formation involved in morphogenesis
|
GO:0048646 |
284 |
0.016
|
|
|
|
activation of cysteine type endopeptidase activity involved in apoptotic process
|
GO:0006919 |
49 |
0.015
|
|
|
|
lipid biosynthetic process
|
GO:0008610 |
177 |
0.015
|
|
|
|
transmembrane receptor protein tyrosine kinase signaling pathway
|
GO:0007169 |
181 |
0.015
|
|
|
|
protein import
|
GO:0017038 |
130 |
0.015
|
|
|
|
negative regulation of apoptotic process
|
GO:0043066 |
316 |
0.015
|
|
|
|
positive regulation of cytokine production involved in immune response
|
GO:0002720 |
6 |
0.015
|
Mouse |
|
|
lipid modification
|
GO:0030258 |
84 |
0.015
|
|
|
|
fatty acid metabolic process
|
GO:0006631 |
115 |
0.015
|
|
|
|
multicellular organismal signaling
|
GO:0035637 |
34 |
0.015
|
|
|
|
regulation of dna binding
|
GO:0051101 |
37 |
0.015
|
|
|
|
activation of cysteine type endopeptidase activity
|
GO:0097202 |
57 |
0.015
|
|
|
|
single organismal cell cell adhesion
|
GO:0016337 |
148 |
0.015
|
|
|
|
protein catabolic process
|
GO:0030163 |
325 |
0.015
|
Human |
|
|
leukocyte apoptotic process
|
GO:0071887 |
31 |
0.015
|
|
|
|
positive regulation of nucleotide metabolic process
|
GO:0045981 |
230 |
0.014
|
Human |
|
|
intrinsic apoptotic signaling pathway
|
GO:0097193 |
127 |
0.014
|
|
|
|
plasma lipoprotein particle clearance
|
GO:0034381 |
16 |
0.014
|
|
|
|
positive regulation of bone resorption
|
GO:0045780 |
2 |
0.014
|
|
|
|
regulation of intracellular protein transport
|
GO:0033157 |
123 |
0.014
|
|
|
|
regulation of immunoglobulin secretion
|
GO:0051023 |
1 |
0.014
|
|
|
|
cytokine metabolic process
|
GO:0042107 |
38 |
0.014
|
Human |
|
|
cellular response to growth factor stimulus
|
GO:0071363 |
197 |
0.014
|
|
|
|
chloride transport
|
GO:0006821 |
41 |
0.014
|
|
|
|
regulation of response to wounding
|
GO:1903034 |
101 |
0.014
|
|
|
|
organic acid transport
|
GO:0015849 |
65 |
0.014
|
|
|
|
intracellular protein transport
|
GO:0006886 |
270 |
0.014
|
|
|
|
negative regulation of cellular component organization
|
GO:0051129 |
235 |
0.014
|
|
|
|
maintenance of protein location in cell
|
GO:0032507 |
56 |
0.014
|
|
|
|
blood vessel development
|
GO:0001568 |
172 |
0.014
|
|
|
|
regulation of cell migration
|
GO:0030334 |
289 |
0.014
|
Mouse |
|
|
determination of adult lifespan
|
GO:0008340 |
2 |
0.014
|
|
|
|
microtubule based process
|
GO:0007017 |
210 |
0.014
|
|
|
|
negative regulation of transferase activity
|
GO:0051348 |
124 |
0.014
|
|
|
|
cytokine secretion
|
GO:0050663 |
64 |
0.014
|
Mouse |
|
|
actin cytoskeleton organization
|
GO:0030036 |
207 |
0.014
|
|
|
|
mitotic cell cycle
|
GO:0000278 |
326 |
0.013
|
|
|
|
response to inorganic substance
|
GO:0010035 |
127 |
0.013
|
|
|
|
negative regulation of intracellular transport
|
GO:0032387 |
60 |
0.013
|
|
|
|
regulation of dna metabolic process
|
GO:0051052 |
153 |
0.013
|
|
|
|
regulation of gtp catabolic process
|
GO:0033124 |
180 |
0.013
|
Human |
|
|
neuroblast proliferation
|
GO:0007405 |
4 |
0.013
|
|
|
|
regulation of inflammatory response
|
GO:0050727 |
46 |
0.013
|
|
|
|
purine nucleoside triphosphate metabolic process
|
GO:0009144 |
412 |
0.013
|
Human |
|
|
nitrogen compound transport
|
GO:0071705 |
191 |
0.013
|
|
|
|
ectoderm development
|
GO:0007398 |
3 |
0.013
|
|
|
|
regulation of cell cycle
|
GO:0051726 |
393 |
0.013
|
|
|
|
cell projection organization
|
GO:0030030 |
252 |
0.013
|
|
|
|
regulation of gtpase activity
|
GO:0043087 |
180 |
0.013
|
Human |
|
|
segmentation
|
GO:0035282 |
4 |
0.013
|
|
|
|
protein kinase c activating g protein coupled receptor signaling pathway
|
GO:0007205 |
2 |
0.013
|
|
|
|
regulation of rho protein signal transduction
|
GO:0035023 |
79 |
0.013
|
Human |
|
|
positive regulation of organic acid transport
|
GO:0032892 |
3 |
0.013
|
|
|
|
cellular response to muramyl dipeptide
|
GO:0071225 |
3 |
0.013
|
|
|
|
innate immune response
|
GO:0045087 |
178 |
0.013
|
|
|
|
glycerophospholipid metabolic process
|
GO:0006650 |
84 |
0.013
|
|
|
|
actin filament based process
|
GO:0030029 |
224 |
0.013
|
|
|
|
spermatid differentiation
|
GO:0048515 |
4 |
0.013
|
|
|
|
monocarboxylic acid metabolic process
|
GO:0032787 |
185 |
0.013
|
|
|
|
extrinsic apoptotic signaling pathway via death domain receptors
|
GO:0008625 |
42 |
0.013
|
|
|
|
negative regulation of humoral immune response
|
GO:0002921 |
7 |
0.013
|
|
|
|
oocyte development
|
GO:0048599 |
1 |
0.013
|
|
|
|
positive regulation of dna metabolic process
|
GO:0051054 |
73 |
0.012
|
|
|
|
negative regulation of cytoplasmic transport
|
GO:1903650 |
46 |
0.012
|
|
|
|
positive regulation of erk1 and erk2 cascade
|
GO:0070374 |
75 |
0.012
|
Human |
|
|
acylglycerol metabolic process
|
GO:0006639 |
27 |
0.012
|
|
|
|
negative regulation of alpha beta t cell activation
|
GO:0046636 |
3 |
0.012
|
Mouse |
|
|
regulation of synaptic plasticity
|
GO:0048167 |
3 |
0.012
|
|
|
|
cell projection assembly
|
GO:0030031 |
126 |
0.012
|
|
|
|
regulation of nucleoside metabolic process
|
GO:0009118 |
209 |
0.012
|
Human |
|
|
positive regulation of icosanoid secretion
|
GO:0032305 |
3 |
0.012
|
|
|
|
negative regulation of nucleocytoplasmic transport
|
GO:0046823 |
37 |
0.012
|
|
|
|
negative regulation of cell motility
|
GO:2000146 |
104 |
0.012
|
|
|
|
regulation of cellular response to growth factor stimulus
|
GO:0090287 |
76 |
0.012
|
|
|
|
cellular amine metabolic process
|
GO:0044106 |
41 |
0.012
|
|
|
|
post embryonic organ development
|
GO:0048569 |
1 |
0.012
|
|
|
|
regulation of myelination
|
GO:0031641 |
1 |
0.012
|
Human |
|
|
blastoderm segmentation
|
GO:0007350 |
2 |
0.012
|
|
|
|
negative regulation of protein phosphorylation
|
GO:0001933 |
140 |
0.012
|
|
|
|
organophosphate biosynthetic process
|
GO:0090407 |
163 |
0.012
|
|
|
|
regulation of peptidyl tyrosine phosphorylation
|
GO:0050730 |
108 |
0.012
|
Human Mouse |
|
|
small molecule catabolic process
|
GO:0044282 |
92 |
0.012
|
|
|
|
cation homeostasis
|
GO:0055080 |
189 |
0.012
|
Human |
|
|
transforming growth factor beta receptor signaling pathway
|
GO:0007179 |
76 |
0.012
|
|
|
|
response to transforming growth factor beta
|
GO:0071559 |
94 |
0.012
|
|
|
|
leukocyte proliferation
|
GO:0070661 |
74 |
0.011
|
Mouse |
|
|
somatic muscle development
|
GO:0007525 |
1 |
0.011
|
|
|
|
protein localization to membrane
|
GO:0072657 |
160 |
0.011
|
|
|
|
single organism membrane organization
|
GO:0044802 |
268 |
0.011
|
|
|
|
apoptotic mitochondrial changes
|
GO:0008637 |
57 |
0.011
|
|
|
|
glycerolipid biosynthetic process
|
GO:0045017 |
51 |
0.011
|
|
|
|
regulation of icosanoid secretion
|
GO:0032303 |
4 |
0.011
|
|
|
|
vasculature development
|
GO:0001944 |
181 |
0.011
|
|
|
|
negative regulation of cellular amine metabolic process
|
GO:0033239 |
3 |
0.011
|
|
|
|
negative regulation of protein import into nucleus
|
GO:0042308 |
30 |
0.011
|
|
|
|
positive regulation of b cell mediated immunity
|
GO:0002714 |
4 |
0.011
|
|
|
|
glycerolipid metabolic process
|
GO:0046486 |
107 |
0.011
|
|
|
|
positive regulation of fatty acid transport
|
GO:2000193 |
3 |
0.011
|
|
|
|
gtp catabolic process
|
GO:0006184 |
237 |
0.011
|
Human |
|
|
transcription factor import into nucleus
|
GO:0042991 |
40 |
0.011
|
|
|
|
negative regulation of transport
|
GO:0051051 |
176 |
0.011
|
|
|
|
positive regulation of lipid storage
|
GO:0010884 |
10 |
0.011
|
|
|
|
regulation of endocytosis
|
GO:0030100 |
72 |
0.011
|
|
|
|
chemokine production
|
GO:0032602 |
32 |
0.011
|
|
