Homo sapiens

153 known processes

TNFRSF1A

tumor necrosis factor receptor superfamily, member 1A

(Aliases: TNF-R,p60,FPF,TNFAR,TNFR60,CD120a,TNF-R-I,TNFR55,TBP1,MGC19588,TNFR1,p55,TNF-R55,p55-R)

TNFRSF1A biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
programmed necrotic cell death GO:0097300 18 0.935
Human
positive regulation of cellular amine metabolic process GO:0033240 7 0.931
regulation of peptidase activity GO:0052547 180 0.912
intrinsic apoptotic signaling pathway GO:0097193 127 0.905
Human Mouse
amine metabolic process GO:0009308 44 0.904
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.904
i kappab kinase nf kappab signaling GO:0007249 166 0.888
positive regulation of hair follicle development GO:0051798 3 0.883
response to abiotic stimulus GO:0009628 336 0.872
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.862
apoptotic signaling pathway GO:0097190 268 0.848
Human Mouse
cytokine mediated signaling pathway GO:0019221 109 0.834
Mouse Rat
positive regulation of programmed cell death GO:0043068 249 0.831
Human Rat
response to cytokine GO:0034097 232 0.814
Mouse Rat
positive regulation of interleukin 8 production GO:0032757 36 0.783
trail activated apoptotic signaling pathway GO:0036462 4 0.780
Human
positive regulation of cytokine production GO:0001819 167 0.764
Rat
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.736
protein processing GO:0016485 226 0.734
negative regulation of apoptotic process GO:0043066 316 0.729
Rat
cellular amino acid metabolic process GO:0006520 116 0.729
response to mechanical stimulus GO:0009612 51 0.720
regulation of apoptotic signaling pathway GO:2001233 175 0.695
hemopoiesis GO:0030097 180 0.684
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.681
regulation of proteolysis GO:0030162 293 0.681
regulation of cellular amino acid metabolic process GO:0006521 6 0.670
necroptotic signaling pathway GO:0097527 6 0.670
Human
regulation of jnk cascade GO:0046328 73 0.661
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 49 0.660
regulation of myeloid cell differentiation GO:0045637 81 0.649
regulation of cellular ketone metabolic process GO:0010565 50 0.646
negative regulation of programmed cell death GO:0043069 321 0.645
Rat
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.642
positive regulation of cell death GO:0010942 263 0.628
Human Rat
intracellular protein transport GO:0006886 270 0.611
Rat
cell type specific apoptotic process GO:0097285 125 0.606
Rat
adaptive immune response GO:0002250 49 0.597
positive regulation of myeloid leukocyte differentiation GO:0002763 24 0.592
mitotic cell cycle GO:0000278 326 0.581
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 26 0.580
regulation of protein serine threonine kinase activity GO:0071900 179 0.578
regulation of cell differentiation GO:0045595 393 0.576
leukocyte activation GO:0045321 164 0.570
myeloid cell differentiation GO:0030099 117 0.566
protein catabolic process GO:0030163 325 0.562
positive regulation of cell differentiation GO:0045597 211 0.557
positive regulation of phosphorylation GO:0042327 394 0.548
negative regulation of cell death GO:0060548 345 0.537
Rat
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.532
regulation of cytokine production GO:0001817 232 0.523
Rat
positive regulation of leukocyte differentiation GO:1902107 37 0.509
determination of adult lifespan GO:0008340 2 0.491
response to tumor necrosis factor GO:0034612 76 0.488
Mouse Rat
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 16 0.483
protein maturation GO:0051604 233 0.481
osteoclast differentiation GO:0030316 21 0.472
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.469
immune system development GO:0002520 195 0.468
epithelium development GO:0060429 227 0.458
cellular response to tumor necrosis factor GO:0071356 63 0.452
Mouse Rat
cellular response to external stimulus GO:0071496 111 0.449
action potential GO:0001508 34 0.442
cellular response to cytokine stimulus GO:0071345 181 0.442
Mouse Rat
regulation of endopeptidase activity GO:0052548 170 0.435
mitochondrion organization GO:0007005 156 0.429
regulation of protein kinase activity GO:0045859 289 0.425
extrinsic apoptotic signaling pathway GO:0097191 119 0.420
Human
positive regulation of cell proliferation GO:0008284 301 0.413
response to other organism GO:0051707 261 0.408
Zebrafish Mouse Rat
actin filament based movement GO:0030048 17 0.396
tube development GO:0035295 125 0.394
response to oxygen containing compound GO:1901700 369 0.393
Rat
positive regulation of proteolysis GO:0045862 142 0.385
cellular macromolecule catabolic process GO:0044265 380 0.380
zymogen activation GO:0031638 70 0.376
negative regulation of apoptotic signaling pathway GO:2001234 97 0.375
regulation of transferase activity GO:0051338 355 0.358
response to steroid hormone GO:0048545 80 0.352
Rat
cellular response to increased oxygen levels GO:0036295 4 0.352
Human
immune response GO:0006955 307 0.337
Zebrafish
positive regulation of peptidase activity GO:0010952 88 0.334
regulation of stress activated mapk cascade GO:0032872 84 0.332
signal transduction by phosphorylation GO:0023014 297 0.325
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 42 0.307
Human
regulation of membrane potential GO:0042391 95 0.296
regulation of cellular response to stress GO:0080135 244 0.283
regulation of cell migration GO:0030334 289 0.275
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.275
cellular response to mechanical stimulus GO:0071260 39 0.267
lymphocyte mediated immunity GO:0002449 48 0.263
cellular response to molecule of bacterial origin GO:0071219 62 0.259
neuronal action potential GO:0019228 9 0.259
cellular ketone metabolic process GO:0042180 80 0.253
tissue morphogenesis GO:0048729 96 0.253
multicellular organismal aging GO:0010259 3 0.252
positive regulation of map kinase activity GO:0043406 80 0.251
regulation of oxidoreductase activity GO:0051341 43 0.249
mitotic cell cycle process GO:1903047 286 0.249
metal ion homeostasis GO:0055065 169 0.246
single organismal cell cell adhesion GO:0016337 148 0.246
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.242
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.240
regulation of actin cytoskeleton organization GO:0032956 116 0.240
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.237
activation induced cell death of t cells GO:0006924 2 0.236
regulation of defense response GO:0031347 154 0.233
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 52 0.232
regulation of protein localization GO:0032880 296 0.231
Rat
regulation of tyrosine phosphorylation of stat protein GO:0042509 30 0.231
transmission of nerve impulse GO:0019226 11 0.229
positive regulation of mapk cascade GO:0043410 190 0.228
apoptotic mitochondrial changes GO:0008637 57 0.226
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 22 0.226
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.220
protein oligomerization GO:0051259 173 0.217
Rat
regulation of nucleoside metabolic process GO:0009118 209 0.217
positive regulation of hydrolase activity GO:0051345 331 0.213
actin filament based process GO:0030029 224 0.212
response to organonitrogen compound GO:0010243 156 0.212
Rat
response to external biotic stimulus GO:0043207 261 0.211
Zebrafish Mouse Rat
response to lipid GO:0033993 206 0.210
Rat
muscle contraction GO:0006936 73 0.208
cytokine production GO:0001816 247 0.206
Rat
cellular response to endogenous stimulus GO:0071495 336 0.206
Rat
protein import GO:0017038 130 0.205
Rat
negative regulation of protein modification process GO:0031400 200 0.203
response to molecule of bacterial origin GO:0002237 82 0.201
Rat
purine ribonucleoside metabolic process GO:0046128 437 0.201
positive regulation of developmental process GO:0051094 314 0.201
Rat
locomotory behavior GO:0007626 1 0.195
organ morphogenesis GO:0009887 147 0.195
transmembrane transport GO:0055085 399 0.194
response to nitric oxide GO:0071731 4 0.194
regulation of myeloid leukocyte differentiation GO:0002761 39 0.194
leukocyte mediated immunity GO:0002443 59 0.194
positive regulation of protein phosphorylation GO:0001934 313 0.191
regulation of interleukin 8 production GO:0032677 49 0.191
chemical homeostasis GO:0048878 306 0.189
cellular homeostasis GO:0019725 196 0.188
nervous system development GO:0007399 293 0.188
regulation of peptidyl serine phosphorylation GO:0033135 50 0.187
cellular extravasation GO:0045123 21 0.186
response to hormone GO:0009725 175 0.183
Rat
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.178
positive regulation of immune system process GO:0002684 283 0.178
response to virus GO:0009615 126 0.178
purine ribonucleoside catabolic process GO:0046130 398 0.172
positive regulation of protein kinase activity GO:0045860 190 0.169
negative regulation of protein metabolic process GO:0051248 391 0.168
regulation of hair cycle GO:0042634 10 0.166
regulation of leukocyte differentiation GO:1902105 61 0.166
elastic fiber assembly GO:0048251 3 0.164
regulation of protein transport GO:0051223 213 0.163
Rat
regulation of cellular component movement GO:0051270 334 0.162
regulation of inflammatory response GO:0050727 46 0.161
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.160
regulation of mapk cascade GO:0043408 262 0.159
regulation of map kinase activity GO:0043405 108 0.158
negative regulation of intracellular signal transduction GO:1902532 183 0.157
defense response GO:0006952 315 0.156
cell development GO:0048468 328 0.155
regulation of osteoclast differentiation GO:0045670 18 0.154
regulation of cysteine type endopeptidase activity GO:2000116 127 0.153
muscle system process GO:0003012 81 0.152
reactive oxygen species biosynthetic process GO:1903409 4 0.152
cell growth GO:0016049 160 0.151
positive regulation of endopeptidase activity GO:0010950 84 0.148
actin cytoskeleton organization GO:0030036 207 0.145
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.144
Rat
single organism cell adhesion GO:0098602 179 0.143
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 20 0.142
positive regulation of transferase activity GO:0051347 227 0.142
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.142
membrane protein ectodomain proteolysis GO:0006509 33 0.142
positive regulation of interleukin 8 biosynthetic process GO:0045416 8 0.141
multicellular organismal signaling GO:0035637 34 0.140
regulation of epidermis development GO:0045682 19 0.137
cytokine biosynthetic process GO:0042089 37 0.137
interleukin 6 production GO:0032635 37 0.137
Rat
central nervous system development GO:0007417 123 0.135
regulation of cell cycle GO:0051726 393 0.134
cellular response to dna damage stimulus GO:0006974 379 0.134
Mouse
nucleoside triphosphate metabolic process GO:0009141 422 0.133
regulation of protein complex assembly GO:0043254 147 0.131
interleukin 8 production GO:0032637 51 0.130
cytokine metabolic process GO:0042107 38 0.129
regulation of leukocyte mediated immunity GO:0002703 38 0.129
negative regulation of lipid metabolic process GO:0045833 38 0.126
negative regulation of multicellular organismal process GO:0051241 317 0.126
Rat
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.125
neuron death GO:0070997 65 0.123
Rat
organonitrogen compound biosynthetic process GO:1901566 200 0.122
aging GO:0007568 66 0.121
cellular amine metabolic process GO:0044106 41 0.120
skeletal muscle contraction GO:0003009 16 0.119
positive regulation of defense response GO:0031349 87 0.119
Mouse
cellular response to organonitrogen compound GO:0071417 124 0.119
immune effector process GO:0002252 159 0.118
regulation of kinase activity GO:0043549 314 0.117
lymphocyte apoptotic process GO:0070227 20 0.117
regulation of locomotion GO:0040012 329 0.116
lipid catabolic process GO:0016042 84 0.115
cdc42 protein signal transduction GO:0032488 4 0.115
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902043 3 0.114
regulation of cell cycle process GO:0010564 266 0.112
positive regulation of kinase activity GO:0033674 204 0.111
protein targeting GO:0006605 187 0.110
Rat
cellular cation homeostasis GO:0030003 163 0.110
negative regulation of protein phosphorylation GO:0001933 140 0.110
mitotic cell cycle phase transition GO:0044772 162 0.109
cellular macromolecular complex assembly GO:0034622 324 0.109
negative regulation of defense response GO:0031348 47 0.109
positive regulation of jnk cascade GO:0046330 52 0.108
nitric oxide biosynthetic process GO:0006809 20 0.108
tube morphogenesis GO:0035239 95 0.108
striated muscle contraction GO:0006941 52 0.107
cell activation GO:0001775 213 0.107
positive regulation of jak stat cascade GO:0046427 35 0.106
response to lipopolysaccharide GO:0032496 70 0.105
Rat
hematopoietic or lymphoid organ development GO:0048534 186 0.104
organic hydroxy compound metabolic process GO:1901615 147 0.102
response to growth factor GO:0070848 205 0.102
positive regulation of apoptotic signaling pathway GO:2001235 70 0.101
regulation of lymphocyte mediated immunity GO:0002706 33 0.100
anterior posterior axis specification GO:0009948 2 0.100
response to bacterium GO:0009617 144 0.100
Zebrafish Mouse Rat
nucleotide catabolic process GO:0009166 408 0.099
neurological system process GO:0050877 163 0.098
cell cycle phase transition GO:0044770 173 0.098
regulation of system process GO:0044057 101 0.097
activation of mapk activity GO:0000187 45 0.096
ras protein signal transduction GO:0007265 73 0.095
negative regulation of inflammatory response GO:0050728 22 0.095
positive regulation of peptidyl serine phosphorylation GO:0033138 42 0.095
cellular metal ion homeostasis GO:0006875 146 0.095
growth GO:0040007 202 0.094
positive regulation of reactive oxygen species biosynthetic process GO:1903428 2 0.094
regulation of transporter activity GO:0032409 82 0.094
ubiquitin dependent protein catabolic process GO:0006511 206 0.093
female gamete generation GO:0007292 2 0.093
cellular response to nitrogen compound GO:1901699 144 0.093
reactive nitrogen species metabolic process GO:2001057 3 0.092
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.092
positive regulation of hair cycle GO:0042635 3 0.091
cation transport GO:0006812 331 0.091
cytoplasmic transport GO:0016482 379 0.091
Rat
ion homeostasis GO:0050801 230 0.089
activated t cell proliferation GO:0050798 13 0.089
regulation of cytokine biosynthetic process GO:0042035 35 0.088
regulation of cdc42 protein signal transduction GO:0032489 14 0.088
cardiac muscle tissue development GO:0048738 39 0.086
neural tube formation GO:0001841 3 0.085
inorganic cation transmembrane transport GO:0098662 194 0.085
positive regulation of t cell proliferation GO:0042102 33 0.084
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.084
Mouse
regulation of mitotic cell cycle GO:0007346 189 0.084
enzyme linked receptor protein signaling pathway GO:0007167 303 0.082
reactive oxygen species metabolic process GO:0072593 75 0.082
epithelial tube morphogenesis GO:0060562 38 0.082
system process GO:0003008 349 0.082
cellular response to growth factor stimulus GO:0071363 197 0.081
negative regulation of t cell apoptotic process GO:0070233 4 0.080
regulation of reactive oxygen species metabolic process GO:2000377 41 0.080
regulation of establishment of protein localization GO:0070201 242 0.080
Rat
positive regulation of cell migration GO:0030335 172 0.080
alcohol metabolic process GO:0006066 114 0.080
protein modification by small protein conjugation GO:0032446 342 0.079
circulatory system development GO:0072359 262 0.079
Rat
negative regulation of phosphate metabolic process GO:0045936 267 0.078
embryo development GO:0009790 123 0.077
purine nucleoside triphosphate metabolic process GO:0009144 412 0.077
actin filament organization GO:0007015 128 0.077
positive regulation of tumor necrosis factor superfamily cytokine production GO:1903557 22 0.077
Rat
negative regulation of response to external stimulus GO:0032102 83 0.076
posttranscriptional regulation of gene expression GO:0010608 213 0.076
lipid metabolic process GO:0006629 381 0.075
secretion by cell GO:0032940 226 0.075
musculoskeletal movement GO:0050881 17 0.075
lipid biosynthetic process GO:0008610 177 0.075
regulation of monooxygenase activity GO:0032768 22 0.075
establishment of protein localization to organelle GO:0072594 172 0.075
Rat
positive regulation of calcidiol 1 monooxygenase activity GO:0060559 3 0.074
nucleoside catabolic process GO:0009164 408 0.074
regulation of ion transmembrane transport GO:0034765 132 0.074
response to nitrogen compound GO:1901698 184 0.074
Rat
regulation of multi organism process GO:0043900 157 0.073
thymus development GO:0048538 3 0.072
response to endoplasmic reticulum stress GO:0034976 49 0.072
Human
regulation of protein localization to cell surface GO:2000008 15 0.071
nuclear transport GO:0051169 179 0.070
Rat
homeostasis of number of cells GO:0048872 40 0.070
maintenance of location GO:0051235 112 0.070
regulation of heart contraction GO:0008016 50 0.069
receptor metabolic process GO:0043112 81 0.068
gland development GO:0048732 48 0.067
positive regulation of cell activation GO:0050867 81 0.066
post embryonic development GO:0009791 2 0.066
striated muscle tissue development GO:0014706 59 0.066
tumor necrosis factor production GO:0032640 43 0.066
Rat
neural nucleus development GO:0048857 47 0.065
purine nucleoside monophosphate metabolic process GO:0009126 186 0.065
regulation of lipid biosynthetic process GO:0046890 47 0.064
morphogenesis of an epithelium GO:0002009 60 0.064
morphogenesis of embryonic epithelium GO:0016331 4 0.064
dephosphorylation GO:0016311 209 0.063
positive regulation of cellular component organization GO:0051130 376 0.063
regulation of cell growth GO:0001558 135 0.063
protein targeting to nucleus GO:0044744 104 0.063
Rat
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.063
protein localization to membrane GO:0072657 160 0.062
heart development GO:0007507 95 0.062
negative regulation of response to wounding GO:1903035 47 0.062
response to wounding GO:0009611 168 0.062
negative regulation of catalytic activity GO:0043086 335 0.062
proteasomal protein catabolic process GO:0010498 176 0.062
nitrogen compound transport GO:0071705 191 0.061
negative regulation of lipid catabolic process GO:0050995 9 0.061
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.061
cellular response to oxygen containing compound GO:1901701 276 0.060
Rat
biological adhesion GO:0022610 331 0.059
head development GO:0060322 108 0.058
regulation of cellular amine metabolic process GO:0033238 11 0.058
necrotic cell death GO:0070265 21 0.058
Human
response to biotic stimulus GO:0009607 276 0.058
Zebrafish Mouse Rat
platelet formation GO:0030220 4 0.058
modification dependent protein catabolic process GO:0019941 209 0.058
ion transmembrane transport GO:0034220 338 0.057
actomyosin structure organization GO:0031032 59 0.057
neuron projection development GO:0031175 106 0.057
regulation of intracellular transport GO:0032386 195 0.057
Rat
purine nucleotide catabolic process GO:0006195 405 0.057
positive regulation of protein binding GO:0032092 24 0.057
epithelial cell differentiation GO:0030855 141 0.056
macrophage differentiation GO:0030225 11 0.056
positive regulation of cellular catabolic process GO:0031331 284 0.056
hair cycle GO:0042633 28 0.055
cell adhesion GO:0007155 325 0.055
heart morphogenesis GO:0003007 48 0.055
ribonucleoside catabolic process GO:0042454 406 0.055
peptidyl serine modification GO:0018209 106 0.055
cardiac muscle contraction GO:0060048 34 0.054
regulation of nucleotide catabolic process GO:0030811 205 0.054
small gtpase mediated signal transduction GO:0007264 78 0.054
regulation of immune response GO:0050776 201 0.054
lung morphogenesis GO:0060425 6 0.054
midgut development GO:0007494 1 0.054
negative regulation of cellular amine metabolic process GO:0033239 3 0.054
positive regulation of cdc42 gtpase activity GO:0043089 6 0.053
viral process GO:0016032 146 0.053
intracellular protein transmembrane transport GO:0065002 24 0.053
protein autophosphorylation GO:0046777 123 0.052
positive regulation of gtp catabolic process GO:0033126 166 0.052
skin development GO:0043588 76 0.052
fat soluble vitamin metabolic process GO:0006775 19 0.052
nucleoside monophosphate catabolic process GO:0009125 159 0.052
positive regulation of apoptotic process GO:0043065 246 0.052
Human Rat
regulation of protein targeting GO:1903533 91 0.052
Rat
negative regulation of smooth muscle cell migration GO:0014912 7 0.051
midbrain development GO:0030901 45 0.051
regulation of erk1 and erk2 cascade GO:0070372 99 0.051
regulation of protein secretion GO:0050708 86 0.051
salivary gland morphogenesis GO:0007435 4 0.050
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.050
negative regulation of phosphorus metabolic process GO:0010563 267 0.050
cellular protein complex assembly GO:0043623 188 0.050
response to reactive oxygen species GO:0000302 61 0.050
blood circulation GO:0008015 113 0.050
response to light stimulus GO:0009416 87 0.049
negative regulation of cellular protein metabolic process GO:0032269 353 0.049
protein import into nucleus GO:0006606 104 0.049
Rat
positive regulation of leukocyte mediated immunity GO:0002705 24 0.049
regulation of gtp catabolic process GO:0033124 180 0.049
organophosphate catabolic process GO:0046434 430 0.049
multicellular organismal movement GO:0050879 17 0.049
regulation of cytoplasmic transport GO:1903649 149 0.048
Rat
positive regulation of cellular component movement GO:0051272 181 0.048
regulation of cellular component biogenesis GO:0044087 281 0.048
negative regulation of secretion by cell GO:1903531 52 0.048
neuron development GO:0048666 113 0.048
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.048
vasculature development GO:0001944 181 0.048
Rat
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 15 0.048
regulation of ion homeostasis GO:2000021 73 0.047
purine nucleoside monophosphate catabolic process GO:0009128 158 0.047
neuron apoptotic process GO:0051402 39 0.047
Rat
positive regulation of locomotion GO:0040017 186 0.047
chemokine biosynthetic process GO:0042033 4 0.047
protein localization to endoplasmic reticulum GO:0070972 19 0.046
circulatory system process GO:0003013 113 0.046
anion transport GO:0006820 161 0.046
regulation of g1 s transition of mitotic cell cycle GO:2000045 40 0.046
anatomical structure formation involved in morphogenesis GO:0048646 284 0.046
Rat
cell cell signaling GO:0007267 155 0.046
positive regulation of lymphocyte migration GO:2000403 16 0.045
cellular chemical homeostasis GO:0055082 180 0.045
regulation of purine nucleotide catabolic process GO:0033121 205 0.045
regulation of protein processing GO:0070613 150 0.045
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.045
regulation of cell motility GO:2000145 299 0.045
peripheral nervous system development GO:0007422 2 0.044
response to decreased oxygen levels GO:0036293 96 0.044
Rat
protein localization to cell surface GO:0034394 28 0.044
oogenesis GO:0048477 2 0.044
positive regulation of t cell activation GO:0050870 54 0.043
t cell homeostasis GO:0043029 3 0.043
cellular response to hyperoxia GO:0071455 4 0.043
Human
regulation of immunoglobulin production GO:0002637 4 0.043
nucleoside monophosphate metabolic process GO:0009123 191 0.043
release of cytochrome c from mitochondria GO:0001836 35 0.042
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.042
memory GO:0007613 3 0.042
chemokine c x c motif ligand 2 production GO:0072567 3 0.041
rho protein signal transduction GO:0007266 26 0.041
positive regulation of epidermis development GO:0045684 11 0.041
negative regulation of homeostatic process GO:0032845 59 0.041
regulation of hair follicle development GO:0051797 5 0.040
regulation of rho protein signal transduction GO:0035023 79 0.040
response to nicotine GO:0035094 12 0.039
ribonucleoside triphosphate metabolic process GO:0009199 412 0.039
erk1 and erk2 cascade GO:0070371 104 0.039
chordate embryonic development GO:0043009 34 0.039
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.039
myeloid leukocyte differentiation GO:0002573 60 0.038
myosin filament assembly GO:0031034 2 0.038
epidermis development GO:0008544 59 0.038
positive regulation of lipid biosynthetic process GO:0046889 22 0.038
negative regulation of developmental process GO:0051093 247 0.038
ribonucleoside monophosphate metabolic process GO:0009161 187 0.038
neuron differentiation GO:0030182 138 0.037
sphingolipid metabolic process GO:0006665 38 0.037
positive regulation of cell motility GO:2000147 177 0.037
cell projection organization GO:0030030 252 0.037
positive regulation of cell cycle GO:0045787 140 0.037
protein homooligomerization GO:0051260 100 0.037
regulation of lymphocyte activation GO:0051249 103 0.037
platelet morphogenesis GO:0036344 4 0.037
cellular component disassembly GO:0022411 92 0.037
amino acid transport GO:0006865 28 0.037
purine nucleoside catabolic process GO:0006152 398 0.036
positive regulation of transport GO:0051050 336 0.036
Rat
response to peptide hormone GO:0043434 61 0.036
positive regulation of cell adhesion GO:0045785 84 0.036
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.036
positive regulation of alcohol biosynthetic process GO:1902932 9 0.036
segmentation GO:0035282 4 0.036
nucleoside triphosphate catabolic process GO:0009143 394 0.035
cellular response to muramyl dipeptide GO:0071225 3 0.035
defense response to virus GO:0051607 71 0.035
neurogenesis GO:0022008 169 0.035
single organism carbohydrate metabolic process GO:0044723 193 0.035
negative regulation of catabolic process GO:0009895 104 0.034
positive regulation of cell cycle process GO:0090068 106 0.034
type i interferon signaling pathway GO:0060337 11 0.034
response to hyperoxia GO:0055093 4 0.034
Human
regulation of rho gtpase activity GO:0032319 66 0.034
cellular ion homeostasis GO:0006873 168 0.034
positive regulation of cell cycle arrest GO:0071158 23 0.034
brain development GO:0007420 97 0.033
response to oxygen levels GO:0070482 100 0.033
Human Rat
leukocyte differentiation GO:0002521 98 0.033
regulation of jun kinase activity GO:0043506 27 0.033
mitotic cell cycle checkpoint GO:0007093 68 0.033
regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 24 0.033
organelle assembly GO:0070925 176 0.033
cellular protein catabolic process GO:0044257 261 0.033
regulation of immune effector process GO:0002697 91 0.033
negative regulation of protein catabolic process GO:0042177 59 0.033
striated muscle myosin thick filament assembly GO:0071688 2 0.032
regulation of striated muscle contraction GO:0006942 37 0.032
rna destabilization GO:0050779 1 0.032
spleen development GO:0048536 1 0.032
calcium ion homeostasis GO:0055074 122 0.032
cellular response to biotic stimulus GO:0071216 71 0.032
maintenance of location in cell GO:0051651 62 0.032
regulation of cytoskeleton organization GO:0051493 177 0.032
cell division GO:0051301 168 0.032
regulation of dna metabolic process GO:0051052 153 0.031
negative regulation of endopeptidase activity GO:0010951 84 0.031

TNFRSF1A disease predictions

Disease DO term ID Size Probability Func Analog Org
immune system disease DOID:2914 155 0.846
Human
auditory system disease DOID:2742 53 0.121
sensory system disease DOID:0050155 203 0.121
nervous system disease DOID:863 431 0.121
disease of metabolism DOID:0014667 295 0.098
lipid storage disease DOID:9455 28 0.098
lysosomal storage disease DOID:3211 47 0.098
inherited metabolic disorder DOID:655 242 0.098
cancer DOID:162 167 0.051
Human
disease of cellular proliferation DOID:14566 174 0.051
Human
parasitic infectious disease DOID:1398 16 0.049
disease by infectious agent DOID:0050117 34 0.049
parasitic protozoa infectious disease DOID:2789 16 0.049
hematopoietic system disease DOID:74 100 0.047
nonsyndromic deafness DOID:0050563 50 0.040
malaria DOID:12365 16 0.032