Homo sapiens

71 known processes

TNKS2

tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2

(Aliases: PARP5B,PARP5C,pART6,TANK2,PARP-5c,PARP-5b,TNKL)

TNKS2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
angiotensin activated signaling pathway GO:0038166 4 0.907
cellular response to oxygen levels GO:0071453 55 0.344
protein glycosylation GO:0006486 62 0.342
protein ubiquitination GO:0016567 314 0.331
response to abiotic stimulus GO:0009628 336 0.305
cellular response to decreased oxygen levels GO:0036294 51 0.302
cellular response to hypoxia GO:0071456 51 0.276
protein modification by small protein conjugation GO:0032446 342 0.261
regulation of neuronal synaptic plasticity GO:0048168 1 0.247
glycoprotein biosynthetic process GO:0009101 91 0.211
response to hypoxia GO:0001666 96 0.197
canonical wnt signaling pathway GO:0060070 116 0.188
peptidyl serine phosphorylation GO:0018105 101 0.175
Human
cell development GO:0048468 328 0.171
response to oxygen levels GO:0070482 100 0.167
regulation of canonical wnt signaling pathway GO:0060828 88 0.149
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.144
regulation of synaptic plasticity GO:0048167 3 0.142
oxidation reduction process GO:0055114 396 0.137
neuromuscular junction development GO:0007528 3 0.132
regulation of striated muscle tissue development GO:0016202 26 0.128
response to decreased oxygen levels GO:0036293 96 0.127
small gtpase mediated signal transduction GO:0007264 78 0.121
post embryonic development GO:0009791 2 0.117
peptide metabolic process GO:0006518 51 0.103
carbohydrate metabolic process GO:0005975 207 0.098
positive regulation of developmental process GO:0051094 314 0.091
mitotic cell cycle process GO:1903047 286 0.091
response to external biotic stimulus GO:0043207 261 0.089
muscle structure development GO:0061061 98 0.089
macromolecule glycosylation GO:0043413 63 0.088
positive regulation of myoblast differentiation GO:0045663 6 0.087
peptidyl serine modification GO:0018209 106 0.086
Human
regulation of ras protein signal transduction GO:0046578 155 0.081
nucleotide catabolic process GO:0009166 408 0.080
regulation of cellular component biogenesis GO:0044087 281 0.080
Fly
regulation of nucleoside metabolic process GO:0009118 209 0.079
notch signaling pathway GO:0007219 31 0.079
system process GO:0003008 349 0.077
ras protein signal transduction GO:0007265 73 0.076
amine metabolic process GO:0009308 44 0.074
positive regulation of catabolic process GO:0009896 310 0.073
glycosylation GO:0070085 71 0.072
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.069
rho protein signal transduction GO:0007266 26 0.067
guanosine containing compound catabolic process GO:1901069 239 0.066
carbohydrate derivative biosynthetic process GO:1901137 207 0.066
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.064
purine ribonucleotide catabolic process GO:0009154 404 0.062
determination of adult lifespan GO:0008340 2 0.061
female gamete generation GO:0007292 2 0.061
cellular response to dna damage stimulus GO:0006974 379 0.061
purine ribonucleoside metabolic process GO:0046128 437 0.060
immune response GO:0006955 307 0.059
cellular amino acid metabolic process GO:0006520 116 0.059
response to biotic stimulus GO:0009607 276 0.059
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.057
positive regulation of transport GO:0051050 336 0.057
regulation of purine nucleotide metabolic process GO:1900542 264 0.057
purine nucleotide catabolic process GO:0006195 405 0.056
ribonucleoside triphosphate catabolic process GO:0009203 391 0.056
single organism carbohydrate metabolic process GO:0044723 193 0.055
cellular macromolecular complex assembly GO:0034622 324 0.055
Fly
ribonucleoside triphosphate metabolic process GO:0009199 412 0.054
locomotory behavior GO:0007626 1 0.052
g protein coupled receptor signaling pathway GO:0007186 207 0.051
cytoplasmic transport GO:0016482 379 0.051
purine containing compound catabolic process GO:0072523 411 0.050
response to other organism GO:0051707 261 0.050
regulation of cell differentiation GO:0045595 393 0.050
synaptic transmission GO:0007268 61 0.049
regulation of telomere maintenance via telomerase GO:0032210 6 0.048
Human
protein localization to organelle GO:0033365 280 0.047
defense response GO:0006952 315 0.047
ribonucleoside catabolic process GO:0042454 406 0.046
cellular macromolecule catabolic process GO:0044265 380 0.046
nucleoside triphosphate catabolic process GO:0009143 394 0.045
wnt signaling pathway GO:0016055 156 0.045
protein catabolic process GO:0030163 325 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.045
response to hormone GO:0009725 175 0.044
cellular amine metabolic process GO:0044106 41 0.044
cellular component morphogenesis GO:0032989 314 0.044
regulation of telomere maintenance GO:0032204 13 0.044
Human
protein deubiquitination GO:0016579 79 0.043
purine ribonucleoside catabolic process GO:0046130 398 0.043
glycerolipid metabolic process GO:0046486 107 0.043
regulation of nucleotide catabolic process GO:0030811 205 0.043
muscle fiber development GO:0048747 16 0.043
endocrine process GO:0050886 25 0.042
negative regulation of binding GO:0051100 57 0.042
Human
purine nucleoside triphosphate metabolic process GO:0009144 412 0.042
regulation of small gtpase mediated signal transduction GO:0051056 156 0.041
neuropeptide catabolic process GO:0010813 2 0.041
cellular amide metabolic process GO:0043603 69 0.041
negative regulation of transcription from rna polymerase ii promoter in response to hypoxia GO:0061428 4 0.039
regulation of cellular amino acid metabolic process GO:0006521 6 0.039
positive regulation of gtp catabolic process GO:0033126 166 0.039
chromatin organization GO:0006325 351 0.039
mitotic cell cycle GO:0000278 326 0.039
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.039
purine nucleoside triphosphate catabolic process GO:0009146 392 0.039
nucleoside catabolic process GO:0009164 408 0.039
negative regulation of notch signaling pathway GO:0045746 10 0.038
skeletal muscle fiber development GO:0048741 12 0.038
regulation of striated muscle cell differentiation GO:0051153 25 0.038
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.037
response to wounding GO:0009611 168 0.036
positive regulation of muscle cell differentiation GO:0051149 15 0.036
regulation of protein complex assembly GO:0043254 147 0.036
Fly
gtp catabolic process GO:0006184 237 0.035
myoblast differentiation GO:0045445 21 0.035
neural tube formation GO:0001841 3 0.035
positive regulation of organelle organization GO:0010638 195 0.035
Human
cellular response to abiotic stimulus GO:0071214 117 0.035
maintenance of location GO:0051235 112 0.035
covalent chromatin modification GO:0016569 254 0.035
regulation of cellular amine metabolic process GO:0033238 11 0.034
guanosine containing compound metabolic process GO:1901068 244 0.034
oogenesis GO:0048477 2 0.034
regulation of myoblast differentiation GO:0045661 12 0.034
apoptotic signaling pathway GO:0097190 268 0.033
positive regulation of nucleotide metabolic process GO:0045981 230 0.033
hindbrain development GO:0030902 3 0.032
response to bacterium GO:0009617 144 0.032
organelle assembly GO:0070925 176 0.031
nucleoside triphosphate metabolic process GO:0009141 422 0.031
lipid metabolic process GO:0006629 381 0.030
multicellular organismal aging GO:0010259 3 0.030
membrane organization GO:0061024 292 0.030
embryonic epithelial tube formation GO:0001838 4 0.030
organ formation GO:0048645 3 0.030
regulation of gtp catabolic process GO:0033124 180 0.030
protein polyubiquitination GO:0000209 110 0.030
regulation of systemic arterial blood pressure GO:0003073 19 0.029
glycosyl compound catabolic process GO:1901658 413 0.029
neurological system process GO:0050877 163 0.029
positive regulation of gtpase activity GO:0043547 166 0.029
ribonucleotide catabolic process GO:0009261 405 0.029
regulation of blood pressure GO:0008217 30 0.028
regulation of muscle organ development GO:0048634 27 0.028
muscle cell differentiation GO:0042692 63 0.028
nucleoside phosphate catabolic process GO:1901292 412 0.028
positive regulation of cellular catabolic process GO:0031331 284 0.027
regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003044 12 0.027
regulation of establishment of protein localization GO:0070201 242 0.027
limbic system development GO:0021761 3 0.026
memory GO:0007613 3 0.026
cell projection organization GO:0030030 252 0.026
cellular protein complex assembly GO:0043623 188 0.026
Fly
regulation of cell cycle GO:0051726 393 0.026
positive regulation of cellular component organization GO:0051130 376 0.026
Human
mitotic nuclear division GO:0007067 119 0.026
regulation of binding GO:0051098 111 0.026
Human
innate immune response GO:0045087 178 0.026
regulation of chromosome organization GO:0033044 103 0.026
Human
regulation of proteolysis GO:0030162 293 0.026
cellular response to radiation GO:0071478 65 0.025
positive regulation of phosphorylation GO:0042327 394 0.025
nervous system development GO:0007399 293 0.025
positive regulation of dna metabolic process GO:0051054 73 0.025
Human
regulation of anatomical structure morphogenesis GO:0022603 286 0.025
positive regulation of hydrolase activity GO:0051345 331 0.025
cell cycle checkpoint GO:0000075 117 0.024
gtp metabolic process GO:0046039 239 0.024
telomere maintenance via telomere lengthening GO:0010833 9 0.024
Human
metencephalon development GO:0022037 2 0.024
response to radiation GO:0009314 151 0.024
glycoprotein metabolic process GO:0009100 110 0.024
regulation of response to external stimulus GO:0032101 222 0.024
actin cytoskeleton organization GO:0030036 207 0.024
membrane protein ectodomain proteolysis GO:0006509 33 0.024
negative regulation of cellular protein metabolic process GO:0032269 353 0.023
regulation of dna metabolic process GO:0051052 153 0.023
Human
regulation of gtpase activity GO:0043087 180 0.023
negative regulation of cellular component organization GO:0051129 235 0.023
epithelium development GO:0060429 227 0.023
endomembrane system organization GO:0010256 196 0.023
behavior GO:0007610 112 0.023
dna integrity checkpoint GO:0031570 71 0.023
cellular chemical homeostasis GO:0055082 180 0.023
positive regulation of wnt signaling pathway GO:0030177 54 0.023
protein dephosphorylation GO:0006470 81 0.023
regulation of nucleotide metabolic process GO:0006140 269 0.023
positive regulation of immune system process GO:0002684 283 0.023
membrane protein proteolysis GO:0033619 38 0.022
positive regulation of cell differentiation GO:0045597 211 0.022
positive regulation of protein transport GO:0051222 135 0.022
dna damage checkpoint GO:0000077 68 0.022
protein processing GO:0016485 226 0.022
cell fate determination GO:0001709 3 0.022
cardiovascular system development GO:0072358 262 0.022
microtubule based process GO:0007017 210 0.022
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.021
purine nucleoside catabolic process GO:0006152 398 0.021
response to uv GO:0009411 73 0.021
regulation of microtubule polymerization GO:0031113 12 0.021
cellular carbohydrate metabolic process GO:0044262 84 0.021
protein polymerization GO:0051258 71 0.021
regulation of growth GO:0040008 165 0.021
Mouse
chromosome segregation GO:0007059 114 0.020
head development GO:0060322 108 0.020
small molecule biosynthetic process GO:0044283 157 0.020
regulation of muscle cell differentiation GO:0051147 31 0.020
neural tube closure GO:0001843 3 0.020
dna replication GO:0006260 116 0.020
Human
inner ear morphogenesis GO:0042472 4 0.020
peptidyl threonine phosphorylation GO:0018107 41 0.020
Human
oocyte differentiation GO:0009994 2 0.019
regulation of rho protein signal transduction GO:0035023 79 0.019
blood circulation GO:0008015 113 0.019
regulation of cellular ketone metabolic process GO:0010565 50 0.019
cell cell signaling GO:0007267 155 0.019
regulation of cytoskeleton organization GO:0051493 177 0.019
morphogenesis of embryonic epithelium GO:0016331 4 0.019
regulation of protein ubiquitination GO:0031396 95 0.019
chemical homeostasis GO:0048878 306 0.019
regulation of muscle tissue development GO:1901861 26 0.019
cell morphogenesis GO:0000902 296 0.019
positive regulation of cellular amine metabolic process GO:0033240 7 0.019
muscle organ development GO:0007517 56 0.019
somitogenesis GO:0001756 2 0.019
organic hydroxy compound metabolic process GO:1901615 147 0.019
striated muscle cell differentiation GO:0051146 43 0.019
cellular protein catabolic process GO:0044257 261 0.019
positive regulation of ras gtpase activity GO:0032320 117 0.019
cell activation GO:0001775 213 0.019
organelle fission GO:0048285 149 0.018
positive regulation of cell cycle GO:0045787 140 0.018
central nervous system development GO:0007417 123 0.018
response to ionizing radiation GO:0010212 65 0.018
rhythmic behavior GO:0007622 2 0.018
organophosphate catabolic process GO:0046434 430 0.018
glycerophospholipid metabolic process GO:0006650 84 0.018
dephosphorylation GO:0016311 209 0.018
nuclear division GO:0000280 128 0.018
adult locomotory behavior GO:0008344 1 0.018
leukocyte differentiation GO:0002521 98 0.018
actin filament based process GO:0030029 224 0.017
regulation of cell cycle process GO:0010564 266 0.017
positive regulation of intracellular transport GO:0032388 104 0.017
protein adp ribosylation GO:0006471 9 0.017
muscle tissue development GO:0060537 62 0.017
modification dependent macromolecule catabolic process GO:0043632 212 0.017
negative regulation of cell proliferation GO:0008285 228 0.017
oocyte development GO:0048599 1 0.017
protein maturation GO:0051604 233 0.017
heart development GO:0007507 95 0.017
segmentation GO:0035282 4 0.017
tube closure GO:0060606 3 0.017
brain development GO:0007420 97 0.017
chromatin modification GO:0016568 298 0.017
regulation of skeletal muscle fiber development GO:0048742 12 0.017
wound healing GO:0042060 115 0.017
melanin metabolic process GO:0006582 1 0.017
regulation of intracellular transport GO:0032386 195 0.017
skeletal muscle organ development GO:0060538 26 0.016
cell fate commitment involved in pattern specification GO:0060581 1 0.016
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.016
positive regulation of nucleoside metabolic process GO:0045979 186 0.016
protein homooligomerization GO:0051260 100 0.016
regulation of immune response GO:0050776 201 0.016
regulation of microtubule cytoskeleton organization GO:0070507 61 0.016
signal transduction by phosphorylation GO:0023014 297 0.016
generation of neurons GO:0048699 152 0.016
regulation of response to dna damage stimulus GO:2001020 94 0.016
regulation of glycoprotein metabolic process GO:1903018 19 0.016
regulation of purine nucleotide catabolic process GO:0033121 205 0.016
modification dependent protein catabolic process GO:0019941 209 0.015
negative regulation of proteolysis GO:0045861 132 0.015
mitochondrion organization GO:0007005 156 0.015
positive regulation of cellular component movement GO:0051272 181 0.015
cellular response to endogenous stimulus GO:0071495 336 0.015
lipid localization GO:0010876 106 0.015
positive regulation of protein phosphorylation GO:0001934 313 0.015
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.015
negative regulation of catalytic activity GO:0043086 335 0.015
cell adhesion GO:0007155 325 0.015
negative regulation of organelle organization GO:0010639 126 0.015
nuclear transport GO:0051169 179 0.015
demethylation GO:0070988 37 0.015
microtubule cytoskeleton organization GO:0000226 176 0.015
ubiquitin dependent protein catabolic process GO:0006511 206 0.015
peptide catabolic process GO:0043171 10 0.015
circulatory system process GO:0003013 113 0.015
positive regulation of reactive oxygen species metabolic process GO:2000379 24 0.014
cell type specific apoptotic process GO:0097285 125 0.014
biological adhesion GO:0022610 331 0.014
regulation of cell cycle phase transition GO:1901987 126 0.014
morphogenesis of a polarized epithelium GO:0001738 3 0.014
regulation of rho gtpase activity GO:0032319 66 0.014
protein hydroxylation GO:0018126 9 0.014
protein k63 linked deubiquitination GO:0070536 21 0.014
nucleoside monophosphate catabolic process GO:0009125 159 0.014
hemopoiesis GO:0030097 180 0.014
calcium ion homeostasis GO:0055074 122 0.014
golgi vesicle transport GO:0048193 80 0.014
regulation of cytoplasmic transport GO:1903649 149 0.014
positive regulation of telomere maintenance GO:0032206 4 0.014
Human
primary neural tube formation GO:0014020 3 0.014
spermatid development GO:0007286 4 0.014
regulation of response to wounding GO:1903034 101 0.014
organophosphate biosynthetic process GO:0090407 163 0.014
single organism membrane organization GO:0044802 268 0.014
regulation of cellular component movement GO:0051270 334 0.014
positive regulation of protein localization to nucleus GO:1900182 48 0.014
regulation of protein localization GO:0032880 296 0.014
activation of immune response GO:0002253 114 0.013
regulation of meiotic cell cycle GO:0051445 4 0.013
regulation of neural precursor cell proliferation GO:2000177 4 0.013
behavioral response to ethanol GO:0048149 2 0.013
peptidyl tyrosine modification GO:0018212 170 0.013
rna catabolic process GO:0006401 71 0.013
regulation of protein maturation GO:1903317 150 0.013
muscle cell development GO:0055001 29 0.013
response to nitrogen compound GO:1901698 184 0.013
signal transduction by p53 class mediator GO:0072331 72 0.013
compound eye development GO:0048749 1 0.013
cellular homeostasis GO:0019725 196 0.013
regulation of cell division GO:0051302 116 0.013
regulation of cell motility GO:2000145 299 0.013
neuroblast proliferation GO:0007405 4 0.013
protein oligomerization GO:0051259 173 0.013
immune effector process GO:0002252 159 0.013
anterior posterior axis specification GO:0009948 2 0.013
neurogenesis GO:0022008 169 0.013
cellular divalent inorganic cation homeostasis GO:0072503 128 0.012
cellular metal ion homeostasis GO:0006875 146 0.012
regulation of mapk cascade GO:0043408 262 0.012
reproduction GO:0000003 63 0.012
spermatid differentiation GO:0048515 4 0.012
enzyme linked receptor protein signaling pathway GO:0007167 303 0.012
cellular ketone metabolic process GO:0042180 80 0.012
regulation of cellular response to stress GO:0080135 244 0.012
skeletal muscle tissue development GO:0007519 24 0.012
negative regulation of protein metabolic process GO:0051248 391 0.012
dna templated transcription initiation GO:0006352 35 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 47 0.012
regulation of skeletal muscle tissue development GO:0048641 15 0.012
anatomical structure formation involved in morphogenesis GO:0048646 284 0.012
regulation of myotube differentiation GO:0010830 18 0.012
organ morphogenesis GO:0009887 147 0.012
cell part morphogenesis GO:0032990 137 0.012
histone modification GO:0016570 251 0.012
regulation of cell morphogenesis GO:0022604 153 0.012
negative regulation of protein processing GO:0010955 142 0.012
regulation of dna templated transcription in response to stress GO:0043620 18 0.012
regulation of transferase activity GO:0051338 355 0.012
regulation of mitotic cell cycle GO:0007346 189 0.012
associative learning GO:0008306 1 0.012
muscle cell cellular homeostasis GO:0046716 3 0.012
nucleocytoplasmic transport GO:0006913 176 0.012
transmembrane transport GO:0055085 399 0.012
macromolecule methylation GO:0043414 97 0.012
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.012
positive regulation of cytoplasmic transport GO:1903651 82 0.012
cell growth GO:0016049 160 0.011
atp metabolic process GO:0046034 176 0.011
negative regulation of protein catabolic process GO:0042177 59 0.011
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.011
myotube differentiation GO:0014902 22 0.011
cellular response to uv GO:0034644 32 0.011
neurotransmitter secretion GO:0007269 4 0.011
histone methylation GO:0016571 60 0.011
circadian behavior GO:0048512 2 0.011
circulatory system development GO:0072359 262 0.011
organelle localization GO:0051640 84 0.011
regulation of synaptic vesicle transport GO:1902803 3 0.011
protein targeting GO:0006605 187 0.011
nucleoside monophosphate metabolic process GO:0009123 191 0.011
positive regulation of protein complex assembly GO:0031334 86 0.011
anatomical structure homeostasis GO:0060249 100 0.011
Human
response to light stimulus GO:0009416 87 0.011
sister chromatid segregation GO:0000819 54 0.011
tissue regeneration GO:0042246 3 0.011
regulation of nuclear division GO:0051783 65 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.011
mapk cascade GO:0000165 288 0.011
hematopoietic or lymphoid organ development GO:0048534 186 0.011
protein modification by small protein removal GO:0070646 92 0.011
positive regulation of transferase activity GO:0051347 227 0.011
regulation of ion transport GO:0043269 189 0.011
negative regulation of phosphorus metabolic process GO:0010563 267 0.011
endocytosis GO:0006897 159 0.011
protein localization to membrane GO:0072657 160 0.011
cellular lipid metabolic process GO:0044255 303 0.011
myoblast fusion GO:0007520 1 0.011
embryo development GO:0009790 123 0.011
positive regulation of nucleotide catabolic process GO:0030813 185 0.011
synaptic vesicle recycling GO:0036465 3 0.011
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.011
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.011
inflammatory response GO:0006954 79 0.011
maintenance of location in cell GO:0051651 62 0.011
hair cell differentiation GO:0035315 2 0.010
divalent inorganic cation homeostasis GO:0072507 136 0.010
regulation of erk1 and erk2 cascade GO:0070372 99 0.010
regulation of protein processing GO:0070613 150 0.010
i kappab kinase nf kappab signaling GO:0007249 166 0.010
regulation of gene expression epigenetic GO:0040029 73 0.010
regulation of stress activated mapk cascade GO:0032872 84 0.010
intracellular protein transport GO:0006886 270 0.010
ion transmembrane transport GO:0034220 338 0.010
negative regulation of intracellular signal transduction GO:1902532 183 0.010
regulation of meiosis GO:0040020 3 0.010
posttranscriptional regulation of gene expression GO:0010608 213 0.010
meiotic chromosome segregation GO:0045132 4 0.010
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.010
ion homeostasis GO:0050801 230 0.010
cell division GO:0051301 168 0.010
regulation of ras gtpase activity GO:0032318 128 0.010
mitotic cell cycle phase transition GO:0044772 162 0.010
cerebral cortex radially oriented cell migration GO:0021799 1 0.010
regulation of neurotransmitter secretion GO:0046928 3 0.010
cation homeostasis GO:0055080 189 0.010
regulation of epithelial cell proliferation GO:0050678 113 0.010

TNKS2 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.050
cancer DOID:162 167 0.042
organ system cancer DOID:0050686 164 0.024
sensory system disease DOID:0050155 203 0.022
nervous system disease DOID:863 431 0.022
eye and adnexa disease DOID:1492 150 0.014
eye disease DOID:5614 149 0.014
gastrointestinal system cancer DOID:3119 52 0.012
central nervous system disease DOID:331 186 0.012
musculoskeletal system disease DOID:17 223 0.010