Homo sapiens

34 known processes

TOLLIP

toll interacting protein

(Aliases: IL-1RAcPIP,FLJ33531)

TOLLIP biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of protein autophosphorylation GO:0031952 15 0.956
positive regulation of transferase activity GO:0051347 227 0.951
activation of protein kinase activity GO:0032147 90 0.949
positive regulation of protein kinase activity GO:0045860 190 0.946
positive regulation of phosphorylation GO:0042327 394 0.928
positive regulation of protein phosphorylation GO:0001934 313 0.925
protein autophosphorylation GO:0046777 123 0.912
regulation of protein kinase activity GO:0045859 289 0.900
positive regulation of kinase activity GO:0033674 204 0.883
regulation of transferase activity GO:0051338 355 0.877
regulation of kinase activity GO:0043549 314 0.863
regulation of mitotic cell cycle GO:0007346 189 0.783
regulation of mitosis GO:0007088 63 0.765
negative regulation of cellular component organization GO:0051129 235 0.754
positive regulation of protein autophosphorylation GO:0031954 9 0.737
regulation of nuclear division GO:0051783 65 0.688
negative regulation of mitosis GO:0045839 24 0.632
negative regulation of mitotic cell cycle GO:0045930 102 0.585
mitotic cell cycle process GO:1903047 286 0.583
regulation of cell cycle GO:0051726 393 0.553
mitotic cell cycle GO:0000278 326 0.553
mitotic nuclear division GO:0007067 119 0.486
organelle fission GO:0048285 149 0.485
negative regulation of cell division GO:0051782 31 0.467
negative regulation of cell cycle process GO:0010948 121 0.446
negative regulation of cell cycle GO:0045786 193 0.440
negative regulation of organelle organization GO:0010639 126 0.407
regulation of cell cycle process GO:0010564 266 0.308
autophagy GO:0006914 88 0.249
nuclear division GO:0000280 128 0.240
cellular lipid metabolic process GO:0044255 303 0.239
response to other organism GO:0051707 261 0.228
regulation of cell division GO:0051302 116 0.182
organelle assembly GO:0070925 176 0.122
response to biotic stimulus GO:0009607 276 0.120
multicellular organismal aging GO:0010259 3 0.108
reactive nitrogen species metabolic process GO:2001057 3 0.101
determination of adult lifespan GO:0008340 2 0.096
protein catabolic process GO:0030163 325 0.093
vacuole organization GO:0007033 44 0.091
oxidation reduction process GO:0055114 396 0.089
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.085
cellular response to oxygen containing compound GO:1901701 276 0.083
cellular organohalogen metabolic process GO:0090345 2 0.081
reactive oxygen species metabolic process GO:0072593 75 0.079
negative regulation of protein serine threonine kinase activity GO:0071901 57 0.078
cellular amino acid metabolic process GO:0006520 116 0.078
regulation of cellular amino acid metabolic process GO:0006521 6 0.077
amine metabolic process GO:0009308 44 0.072
regulation of mapk cascade GO:0043408 262 0.067
mapk cascade GO:0000165 288 0.067
negative regulation of intracellular signal transduction GO:1902532 183 0.066
cofactor metabolic process GO:0051186 87 0.065
secretion GO:0046903 254 0.061
toll like receptor 2 signaling pathway GO:0034134 4 0.060
interleukin 6 production GO:0032635 37 0.058
cellular response to hypoxia GO:0071456 51 0.058
regulation of cellular response to stress GO:0080135 244 0.058
regulation of secretion GO:0051046 194 0.056
response to bacterium GO:0009617 144 0.055
cell division GO:0051301 168 0.055
defense response GO:0006952 315 0.054
regulation of map kinase activity GO:0043405 108 0.052
negative regulation of protein metabolic process GO:0051248 391 0.051
female gamete generation GO:0007292 2 0.050
response to external biotic stimulus GO:0043207 261 0.050
response to inorganic substance GO:0010035 127 0.050
nitrogen compound transport GO:0071705 191 0.050
inorganic ion transmembrane transport GO:0098660 231 0.049
response to oxygen containing compound GO:1901700 369 0.049
regulation of cellular component biogenesis GO:0044087 281 0.049
cellular amine metabolic process GO:0044106 41 0.048
response to oxidative stress GO:0006979 121 0.048
regulation of synaptic plasticity GO:0048167 3 0.047
positive regulation of apoptotic process GO:0043065 246 0.046
single organism cellular localization GO:1902580 332 0.046
post embryonic development GO:0009791 2 0.045
cellular ketone metabolic process GO:0042180 80 0.045
regulation of cellular ketone metabolic process GO:0010565 50 0.045
negative regulation of reactive oxygen species metabolic process GO:2000378 11 0.045
protein localization to organelle GO:0033365 280 0.044
purine nucleoside triphosphate metabolic process GO:0009144 412 0.044
nucleoside triphosphate metabolic process GO:0009141 422 0.042
regulation of protein catabolic process GO:0042176 155 0.041
positive regulation of developmental process GO:0051094 314 0.041
negative regulation of apoptotic process GO:0043066 316 0.040
small molecule biosynthetic process GO:0044283 157 0.040
cytoplasmic transport GO:0016482 379 0.040
head development GO:0060322 108 0.040
negative regulation of cellular protein metabolic process GO:0032269 353 0.040
response to fungus GO:0009620 4 0.040
negative regulation of phosphorus metabolic process GO:0010563 267 0.039
regulation of lipid metabolic process GO:0019216 96 0.038
generation of neurons GO:0048699 152 0.037
cytokine production GO:0001816 247 0.036
maintenance of location GO:0051235 112 0.036
single organism membrane organization GO:0044802 268 0.035
regulation of autophagy GO:0010506 52 0.035
regulation of cellular amine metabolic process GO:0033238 11 0.035
lipid oxidation GO:0034440 33 0.035
purine ribonucleotide catabolic process GO:0009154 404 0.034
signal transduction by phosphorylation GO:0023014 297 0.033
regulation of protein maturation GO:1903317 150 0.033
negative regulation of protein maturation GO:1903318 142 0.032
cell morphogenesis GO:0000902 296 0.032
cellular macromolecular complex assembly GO:0034622 324 0.032
monovalent inorganic cation transport GO:0015672 128 0.032
ion transmembrane transport GO:0034220 338 0.032
negative regulation of protein catabolic process GO:0042177 59 0.032
nervous system development GO:0007399 293 0.031
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 89 0.031
response to abiotic stimulus GO:0009628 336 0.031
dephosphorylation GO:0016311 209 0.031
protein maturation GO:0051604 233 0.031
peptidyl serine modification GO:0018209 106 0.030
negative regulation of tumor necrosis factor production GO:0032720 20 0.030
cell growth GO:0016049 160 0.030
positive regulation of lipid storage GO:0010884 10 0.030
protein oligomerization GO:0051259 173 0.030
positive regulation of cellular amine metabolic process GO:0033240 7 0.030
negative regulation of catalytic activity GO:0043086 335 0.030
negative regulation of map kinase activity GO:0043407 27 0.030
regulation of interleukin 6 production GO:0032675 37 0.030
cellular protein catabolic process GO:0044257 261 0.029
protein processing GO:0016485 226 0.029
cellular response to endogenous stimulus GO:0071495 336 0.029
protein ubiquitination GO:0016567 314 0.029
negative regulation of immune system process GO:0002683 136 0.029
oogenesis GO:0048477 2 0.028
wnt signaling pathway GO:0016055 156 0.028
regulation of secretion by cell GO:1903530 177 0.028
cation transport GO:0006812 331 0.028
response to metal ion GO:0010038 84 0.028
regulation of protein serine threonine kinase activity GO:0071900 179 0.027
endomembrane system organization GO:0010256 196 0.027
reactive oxygen species biosynthetic process GO:1903409 4 0.027
response to uv GO:0009411 73 0.027
negative regulation of transferase activity GO:0051348 124 0.026
negative regulation of protein phosphorylation GO:0001933 140 0.026
lipid biosynthetic process GO:0008610 177 0.026
negative regulation of phosphate metabolic process GO:0045936 267 0.026
growth GO:0040007 202 0.025
central nervous system development GO:0007417 123 0.025
anterior posterior axis specification GO:0009948 2 0.025
positive regulation of cell differentiation GO:0045597 211 0.025
ribonucleoside monophosphate catabolic process GO:0009158 158 0.024
lipid metabolic process GO:0006629 381 0.024
apoptotic signaling pathway GO:0097190 268 0.024
transmembrane transport GO:0055085 399 0.024
regulation of reactive oxygen species metabolic process GO:2000377 41 0.024
hindbrain development GO:0030902 3 0.024
negative regulation of phosphorylation GO:0042326 174 0.024
regulation of dephosphorylation GO:0035303 96 0.024
hematopoietic or lymphoid organ development GO:0048534 186 0.023
intracellular protein transport GO:0006886 270 0.023
purine ribonucleoside metabolic process GO:0046128 437 0.023
cellular response to extracellular stimulus GO:0031668 72 0.023
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.023
ribonucleoside triphosphate metabolic process GO:0009199 412 0.023
positive regulation of transport GO:0051050 336 0.023
regulation of reactive oxygen species biosynthetic process GO:1903426 3 0.023
establishment of protein localization to organelle GO:0072594 172 0.023
atp catabolic process GO:0006200 157 0.023
jnk cascade GO:0007254 80 0.023
ubiquitin dependent protein catabolic process GO:0006511 206 0.022
negative regulation of protein processing GO:0010955 142 0.022
positive regulation of organelle organization GO:0010638 195 0.022
negative regulation of tumor necrosis factor superfamily cytokine production GO:1903556 20 0.022
regulation of growth GO:0040008 165 0.022
regulation of peptidase activity GO:0052547 180 0.022
sensory organ development GO:0007423 52 0.022
endosomal transport GO:0016197 129 0.021
negative regulation of kinase activity GO:0033673 106 0.021
peptidyl lysine acetylation GO:0018394 101 0.021
cell projection organization GO:0030030 252 0.021
regulation of jnk cascade GO:0046328 73 0.021
monocarboxylic acid metabolic process GO:0032787 185 0.021
rna processing GO:0006396 255 0.021
positive regulation of cellular catabolic process GO:0031331 284 0.021
positive regulation of cell death GO:0010942 263 0.021
negative regulation of cell death GO:0060548 345 0.021
negative regulation of nf kappab transcription factor activity GO:0032088 51 0.021
purine nucleoside monophosphate metabolic process GO:0009126 186 0.021
protein dephosphorylation GO:0006470 81 0.021
nucleotide catabolic process GO:0009166 408 0.020
regulation of stress activated protein kinase signaling cascade GO:0070302 85 0.020
erythrocyte development GO:0048821 3 0.020
cellular response to nutrient levels GO:0031669 69 0.020
negative regulation of proteolysis GO:0045861 132 0.020
regulation of protein ubiquitination GO:0031396 95 0.020
purine containing compound catabolic process GO:0072523 411 0.020
response to oxygen levels GO:0070482 100 0.020
response to peptidoglycan GO:0032494 3 0.020
positive regulation of immune response GO:0050778 159 0.020
cell cycle phase transition GO:0044770 173 0.019
vesicle organization GO:0016050 62 0.019
receptor metabolic process GO:0043112 81 0.019
cation transmembrane transport GO:0098655 238 0.019
dna repair GO:0006281 198 0.019
negative regulation of multicellular organismal process GO:0051241 317 0.019
negative regulation of protein kinase activity GO:0006469 98 0.019
protein modification by small protein conjugation GO:0032446 342 0.019
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.019
nucleoside catabolic process GO:0009164 408 0.019
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.019
cellular response to decreased oxygen levels GO:0036294 51 0.019
secretion by cell GO:0032940 226 0.019
syncytium formation by plasma membrane fusion GO:0000768 2 0.019
regulation of wnt signaling pathway GO:0030111 123 0.018
inner ear morphogenesis GO:0042472 4 0.018
carbohydrate metabolic process GO:0005975 207 0.018
cellular response to oxidative stress GO:0034599 85 0.018
cellular response to lipid GO:0071396 127 0.018
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.018
eye development GO:0001654 42 0.018
positive regulation of protein serine threonine kinase activity GO:0071902 119 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.018
peptidyl serine phosphorylation GO:0018105 101 0.018
organonitrogen compound biosynthetic process GO:1901566 200 0.018
regulation of proteolysis GO:0030162 293 0.018
cofactor biosynthetic process GO:0051188 31 0.018
organ morphogenesis GO:0009887 147 0.017
organophosphate catabolic process GO:0046434 430 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.017
negative regulation of catabolic process GO:0009895 104 0.017
organic acid biosynthetic process GO:0016053 97 0.017
negative regulation of mapk cascade GO:0043409 56 0.017
developmental programmed cell death GO:0010623 3 0.017
defense response to bacterium GO:0042742 63 0.017
embryo development GO:0009790 123 0.017
hair cell differentiation GO:0035315 2 0.017
divalent inorganic cation transport GO:0072511 158 0.017
regulation of stress activated mapk cascade GO:0032872 84 0.017
regulation of protein processing GO:0070613 150 0.017
regulation of innate immune response GO:0045088 97 0.017
lipid catabolic process GO:0016042 84 0.017
negative regulation of protein modification process GO:0031400 200 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.016
endocytosis GO:0006897 159 0.016
response to hypoxia GO:0001666 96 0.016
alcohol metabolic process GO:0006066 114 0.016
immune response GO:0006955 307 0.016
neuron differentiation GO:0030182 138 0.016
tissue homeostasis GO:0001894 63 0.016
positive regulation of apoptotic signaling pathway GO:2001235 70 0.016
fatty acid metabolic process GO:0006631 115 0.016
sequestering of metal ion GO:0051238 24 0.016
regulation of protein transport GO:0051223 213 0.016
positive regulation of lipid metabolic process GO:0045834 50 0.016
cell part morphogenesis GO:0032990 137 0.016
regulation of cytokine production GO:0001817 232 0.016
negative regulation of hydrolase activity GO:0051346 182 0.016
segmentation GO:0035282 4 0.016
stress activated mapk cascade GO:0051403 93 0.016
cellular macromolecule catabolic process GO:0044265 380 0.016
positive regulation of secretion by cell GO:1903532 108 0.016
positive regulation of innate immune response GO:0045089 79 0.015
negative regulation of cytokine production GO:0001818 82 0.015
metencephalon development GO:0022037 2 0.015
endochondral bone morphogenesis GO:0060350 3 0.015
i kappab kinase nf kappab signaling GO:0007249 166 0.015
cell projection morphogenesis GO:0048858 129 0.015
negative regulation of interleukin 6 production GO:0032715 13 0.015
enzyme linked receptor protein signaling pathway GO:0007167 303 0.015
myeloid cell homeostasis GO:0002262 34 0.015
positive regulation of ion transport GO:0043270 87 0.015
nuclear transport GO:0051169 179 0.015
neurological system process GO:0050877 163 0.015
organic hydroxy compound metabolic process GO:1901615 147 0.015
atp metabolic process GO:0046034 176 0.015
cell morphogenesis involved in differentiation GO:0000904 144 0.015
regulation of protein complex assembly GO:0043254 147 0.015
response to radiation GO:0009314 151 0.015
response to organonitrogen compound GO:0010243 156 0.015
neuron development GO:0048666 113 0.015
cellular response to growth factor stimulus GO:0071363 197 0.015
nucleoside monophosphate metabolic process GO:0009123 191 0.015
modification dependent macromolecule catabolic process GO:0043632 212 0.015
reproductive process GO:0022414 106 0.015
g1 s transition of mitotic cell cycle GO:0000082 78 0.015
compound eye development GO:0048749 1 0.014
regulation of apoptotic signaling pathway GO:2001233 175 0.014
spermatid development GO:0007286 4 0.014
regulation of protein dephosphorylation GO:0035304 18 0.014
cell development GO:0048468 328 0.014
exocytosis GO:0006887 71 0.014
protein targeting GO:0006605 187 0.014
cell cell signaling GO:0007267 155 0.014
response to nutrient levels GO:0031667 81 0.014
positive regulation of lipid biosynthetic process GO:0046889 22 0.014
peptidyl lysine modification GO:0018205 144 0.014
regulation of hormone levels GO:0010817 125 0.014
positive regulation of programmed cell death GO:0043068 249 0.014
tumor necrosis factor superfamily cytokine production GO:0071706 45 0.014
regulation of peptidyl serine phosphorylation GO:0033135 50 0.014
purine nucleotide catabolic process GO:0006195 405 0.014
pattern recognition receptor signaling pathway GO:0002221 48 0.014
small molecule catabolic process GO:0044282 92 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.014
response to extracellular stimulus GO:0009991 85 0.014
aging GO:0007568 66 0.014
endosome transport via multivesicular body sorting pathway GO:0032509 3 0.014
modification dependent protein catabolic process GO:0019941 209 0.014
hemopoiesis GO:0030097 180 0.014
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.014
cellular response to biotic stimulus GO:0071216 71 0.014
positive regulation of secretion GO:0051047 116 0.014
response to decreased oxygen levels GO:0036293 96 0.014
regulation of cellular response to growth factor stimulus GO:0090287 76 0.013
negative regulation of growth GO:0045926 97 0.013
blastoderm segmentation GO:0007350 2 0.013
cellular lipid catabolic process GO:0044242 65 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.013
cellular chemical homeostasis GO:0055082 180 0.013
cilium organization GO:0044782 68 0.013
regulation of catecholamine secretion GO:0050433 1 0.013
positive regulation of mapk cascade GO:0043410 190 0.013
single organism carbohydrate metabolic process GO:0044723 193 0.013
immune response regulating signaling pathway GO:0002764 97 0.013
regulation of cholesterol metabolic process GO:0090181 4 0.013
cellular response to cytokine stimulus GO:0071345 181 0.013
positive regulation of immune system process GO:0002684 283 0.013
proteasomal protein catabolic process GO:0010498 176 0.013
regulation of ion transmembrane transport GO:0034765 132 0.013
macroautophagy GO:0016236 39 0.013
cellular response to molecule of bacterial origin GO:0071219 62 0.013
mitotic cell cycle phase transition GO:0044772 162 0.013
glycosyl compound catabolic process GO:1901658 413 0.013
neuromuscular junction development GO:0007528 3 0.013
myeloid cell differentiation GO:0030099 117 0.013
cell cycle g1 s phase transition GO:0044843 80 0.013
regulation of tumor necrosis factor production GO:0032680 43 0.013
gastrulation with mouth forming second GO:0001702 1 0.013
carboxylic acid biosynthetic process GO:0046394 97 0.013
skin development GO:0043588 76 0.013
regulation of ion transport GO:0043269 189 0.012
negative regulation of peptidase activity GO:0010466 91 0.012
chemical homeostasis GO:0048878 306 0.012
regulation of cell growth GO:0001558 135 0.012
purine nucleoside catabolic process GO:0006152 398 0.012
circadian behavior GO:0048512 2 0.012
activation of innate immune response GO:0002218 55 0.012
cellular response to toxic substance GO:0097237 4 0.012
spermatid differentiation GO:0048515 4 0.012
positive regulation of hormone biosynthetic process GO:0046886 4 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.012
apoptotic mitochondrial changes GO:0008637 57 0.012
cellular response to oxygen levels GO:0071453 55 0.012
dopaminergic neuron differentiation GO:0071542 1 0.012
innate immune response GO:0045087 178 0.012
immune response activating signal transduction GO:0002757 90 0.012
nucleoside triphosphate catabolic process GO:0009143 394 0.012
regulation of homeostatic process GO:0032844 121 0.012
defense response to fungus GO:0050832 4 0.012
meiotic chromosome segregation GO:0045132 4 0.012
protein complex disassembly GO:0043241 52 0.012
protein localization to membrane GO:0072657 160 0.012
locomotory behavior GO:0007626 1 0.012
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.012
regulation of hydrogen peroxide mediated programmed cell death GO:1901298 4 0.012
calcium ion transmembrane transport GO:0070588 76 0.012
regulation of tumor necrosis factor superfamily cytokine production GO:1903555 44 0.012
ribonucleotide catabolic process GO:0009261 405 0.011
response to endoplasmic reticulum stress GO:0034976 49 0.011
system process GO:0003008 349 0.011
negative regulation of cellular amine metabolic process GO:0033239 3 0.011
cerebellum development GO:0021549 2 0.011
protein acetylation GO:0006473 116 0.011
cellular response to uv GO:0034644 32 0.011
peripheral nervous system development GO:0007422 2 0.011
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.011
single organism membrane fusion GO:0044801 37 0.011
somatic stem cell maintenance GO:0035019 4 0.011
positive regulation of catabolic process GO:0009896 310 0.011
ion homeostasis GO:0050801 230 0.011
brain development GO:0007420 97 0.011
cation homeostasis GO:0055080 189 0.011
catecholamine secretion GO:0050432 1 0.011
regulation of transmembrane transport GO:0034762 139 0.011
kidney development GO:0001822 53 0.011
embryonic morphogenesis GO:0048598 85 0.011
cellular component morphogenesis GO:0032989 314 0.011
embryo development ending in birth or egg hatching GO:0009792 34 0.011
actin filament based process GO:0030029 224 0.011
negative regulation of transport GO:0051051 176 0.011
epithelial cell differentiation GO:0030855 141 0.011
neuron projection development GO:0031175 106 0.011
positive regulation of nf kappab transcription factor activity GO:0051092 81 0.011
protein acylation GO:0043543 138 0.011
purine nucleoside monophosphate catabolic process GO:0009128 158 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.011
porphyrin containing compound metabolic process GO:0006778 10 0.010
behavioral response to ethanol GO:0048149 2 0.010
regulation of steroid metabolic process GO:0019218 32 0.010
cell projection assembly GO:0030031 126 0.010
ossification GO:0001503 121 0.010
posttranscriptional regulation of gene expression GO:0010608 213 0.010
negative regulation of cell cycle phase transition GO:1901988 89 0.010
nephric duct development GO:0072176 4 0.010
macromolecular complex disassembly GO:0032984 60 0.010
tube closure GO:0060606 3 0.010
defense response to other organism GO:0098542 129 0.010
homeostasis of number of cells GO:0048872 40 0.010
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.010
negative regulation of hydrogen peroxide mediated programmed cell death GO:1901299 3 0.010
cellular component disassembly GO:0022411 92 0.010
positive regulation of amine transport GO:0051954 2 0.010
regulation of anatomical structure size GO:0090066 101 0.010

TOLLIP disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 0.034
inherited metabolic disorder DOID:655 242 0.034
central nervous system disease DOID:331 186 0.017
nervous system disease DOID:863 431 0.017
neurodegenerative disease DOID:1289 102 0.016
disease of cellular proliferation DOID:14566 174 0.013
cancer DOID:162 167 0.012
organ system cancer DOID:0050686 164 0.012