Homo sapiens

151 known processes

TOP2A

topoisomerase (DNA) II alpha 170kDa

(Aliases: TOP2,TP2A)

TOP2A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell cycle GO:0051726 393 0.964
Yeast Fly
sister chromatid segregation GO:0000819 54 0.919
Fly
purine nucleoside monophosphate catabolic process GO:0009128 158 0.910
post embryonic development GO:0009791 2 0.906
Worm
cellular response to dna damage stimulus GO:0006974 379 0.883
mitotic cell cycle GO:0000278 326 0.880
Yeast Fly
chromatin modification GO:0016568 298 0.868
Yeast
nucleoside triphosphate metabolic process GO:0009141 422 0.858
ribonucleotide catabolic process GO:0009261 405 0.744
dna conformation change GO:0071103 113 0.716
negative regulation of cell cycle process GO:0010948 121 0.714
Yeast Fly
purine ribonucleoside monophosphate catabolic process GO:0009169 158 0.691
mitotic sister chromatid segregation GO:0000070 53 0.669
Fly
regulation of cell cycle process GO:0010564 266 0.667
Yeast Fly
atp catabolic process GO:0006200 157 0.662
cell cycle phase transition GO:0044770 173 0.647
Yeast Fly
mitotic cell cycle process GO:1903047 286 0.612
Yeast Fly
nucleoside triphosphate catabolic process GO:0009143 394 0.597
microtubule cytoskeleton organization GO:0000226 176 0.592
Fly
regulation of mitotic cell cycle GO:0007346 189 0.583
Yeast Fly
nucleoside monophosphate catabolic process GO:0009125 159 0.535
chromatin assembly or disassembly GO:0006333 78 0.531
Yeast
negative regulation of cell cycle GO:0045786 193 0.526
Yeast Fly
establishment of organelle localization GO:0051656 59 0.525
Fly
protein localization to nucleus GO:0034504 136 0.522
regulation of cell cycle phase transition GO:1901987 126 0.517
Yeast Fly
ribonucleoside monophosphate metabolic process GO:0009161 187 0.517
dna dependent dna replication GO:0006261 44 0.513
Yeast
mitotic cell cycle phase transition GO:0044772 162 0.503
Yeast Fly
ribonucleoside catabolic process GO:0042454 406 0.466
nucleoside phosphate catabolic process GO:1901292 412 0.454
cell cycle checkpoint GO:0000075 117 0.443
Yeast Fly
nucleoside catabolic process GO:0009164 408 0.413
cellular macromolecular complex assembly GO:0034622 324 0.412
purine nucleotide catabolic process GO:0006195 405 0.410
neuroblast division GO:0055057 1 0.399
purine ribonucleoside catabolic process GO:0046130 398 0.384
meiotic chromosome segregation GO:0045132 4 0.380
protein catabolic process GO:0030163 325 0.376
spindle stabilization GO:0043146 4 0.365
ribonucleoside triphosphate catabolic process GO:0009203 391 0.358
atp metabolic process GO:0046034 176 0.357
nervous system development GO:0007399 293 0.343
purine nucleoside triphosphate catabolic process GO:0009146 392 0.341
nucleoside monophosphate metabolic process GO:0009123 191 0.340
dna recombination GO:0006310 77 0.332
Yeast
purine nucleoside triphosphate metabolic process GO:0009144 412 0.332
neuroblast proliferation GO:0007405 4 0.328
purine nucleoside monophosphate metabolic process GO:0009126 186 0.323
cell division GO:0051301 168 0.319
Mouse
mitotic nuclear division GO:0007067 119 0.314
Fly
response to abiotic stimulus GO:0009628 336 0.312
cytoskeleton dependent cytokinesis GO:0061640 22 0.297
response to organic cyclic compound GO:0014070 204 0.291
single organism nuclear import GO:1902593 104 0.285
chromosome condensation GO:0030261 15 0.280
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.277
Yeast Fly
cellular protein complex assembly GO:0043623 188 0.271
negative regulation of cell cycle phase transition GO:1901988 89 0.261
Yeast Fly
regulation of cell division GO:0051302 116 0.244
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.236
single organism cellular localization GO:1902580 332 0.234
spindle assembly involved in mitosis GO:0090307 12 0.231
regulation of protein import into nucleus GO:0042306 78 0.228
positive regulation of phosphorylation GO:0042327 394 0.226
meiosis i GO:0007127 4 0.225
Yeast
embryo development GO:0009790 123 0.220
Mouse Worm
ribonucleoside triphosphate metabolic process GO:0009199 412 0.217
establishment of protein localization to organelle GO:0072594 172 0.211
nucleocytoplasmic transport GO:0006913 176 0.202
glycosyl compound catabolic process GO:1901658 413 0.194
ribonucleoside monophosphate catabolic process GO:0009158 158 0.193
positive regulation of catabolic process GO:0009896 310 0.192
negative regulation of apoptotic process GO:0043066 316 0.186
modification dependent protein catabolic process GO:0019941 209 0.185
nuclear import GO:0051170 106 0.184
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.184
dna packaging GO:0006323 77 0.184
microtubule based process GO:0007017 210 0.183
Fly
oogenesis GO:0048477 2 0.182
proteasomal protein catabolic process GO:0010498 176 0.177
centrosome organization GO:0051297 58 0.170
nuclear division GO:0000280 128 0.165
Yeast Fly
spindle elongation GO:0051231 4 0.164
covalent chromatin modification GO:0016569 254 0.162
negative regulation of proteolysis GO:0045861 132 0.162
centrosome separation GO:0051299 3 0.161
purine ribonucleotide catabolic process GO:0009154 404 0.157
negative regulation of mitotic cell cycle GO:0045930 102 0.157
Yeast Fly
regulation of mitotic cell cycle phase transition GO:1901990 118 0.155
Yeast Fly
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.154
protein import GO:0017038 130 0.153
microtubule polymerization or depolymerization GO:0031109 37 0.151
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.150
generation of neurons GO:0048699 152 0.148
regulation of protein localization GO:0032880 296 0.148
organelle assembly GO:0070925 176 0.145
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.144
regulation of cellular response to stress GO:0080135 244 0.143
negative regulation of cellular component organization GO:0051129 235 0.140
growth GO:0040007 202 0.140
blastocyst development GO:0001824 3 0.139
regulation of wnt signaling pathway GO:0030111 123 0.139
male gonad development GO:0008584 23 0.133
metaphase plate congression GO:0051310 18 0.131
Fly
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.129
regulation of nucleocytoplasmic transport GO:0046822 98 0.129
sex differentiation GO:0007548 45 0.129
regulation of mitotic sister chromatid segregation GO:0033047 27 0.128
actin cytoskeleton organization GO:0030036 207 0.127
regulation of proteasomal protein catabolic process GO:0061136 87 0.127
protein targeting to nucleus GO:0044744 104 0.126
regulation of chromosome segregation GO:0051983 44 0.124
establishment of nucleus localization GO:0040023 1 0.124
purine containing compound catabolic process GO:0072523 411 0.119
regulation of viral process GO:0050792 103 0.117
cell development GO:0048468 328 0.116
neurogenesis GO:0022008 169 0.116
nucleus localization GO:0051647 1 0.116
ubiquitin dependent protein catabolic process GO:0006511 206 0.115
regulation of dna metabolic process GO:0051052 153 0.115
organelle localization GO:0051640 84 0.114
Fly
circulatory system development GO:0072359 262 0.114
regulation of cell development GO:0060284 161 0.113
modification dependent macromolecule catabolic process GO:0043632 212 0.112
cytokinesis GO:0000910 96 0.112
protein targeting GO:0006605 187 0.111
nucleotide catabolic process GO:0009166 408 0.109
negative regulation of cell death GO:0060548 345 0.108
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.108
regulation of proteolysis GO:0030162 293 0.107
cellular response to endogenous stimulus GO:0071495 336 0.107
cellular macromolecule catabolic process GO:0044265 380 0.105
cellular component morphogenesis GO:0032989 314 0.104
spindle organization GO:0007051 53 0.104
Fly
cardiovascular system development GO:0072358 262 0.104
positive regulation of protein transport GO:0051222 135 0.103
double strand break repair GO:0006302 101 0.103
positive regulation of cell cycle GO:0045787 140 0.100
positive regulation of intracellular transport GO:0032388 104 0.099
regulation of protein catabolic process GO:0042176 155 0.099
regeneration GO:0031099 4 0.098
Zebrafish
protein dna complex subunit organization GO:0071824 80 0.098
dna ligation GO:0006266 10 0.098
maintenance of location GO:0051235 112 0.097
purine nucleoside catabolic process GO:0006152 398 0.095
protein import into nucleus GO:0006606 104 0.094
muscle organ development GO:0007517 56 0.093
chromatin organization GO:0006325 351 0.093
Yeast
regulation of protein targeting GO:1903533 91 0.092
wnt signaling pathway GO:0016055 156 0.090
positive regulation of protein phosphorylation GO:0001934 313 0.090
hematopoietic or lymphoid organ development GO:0048534 186 0.086
Mouse
mitotic centrosome separation GO:0007100 1 0.086
positive regulation of organelle organization GO:0010638 195 0.085
positive regulation of developmental process GO:0051094 314 0.084
immune system development GO:0002520 195 0.083
Mouse
meiotic nuclear division GO:0007126 10 0.082
Yeast
mitotic spindle elongation GO:0000022 4 0.082
dna repair GO:0006281 198 0.081
response to oxygen containing compound GO:1901700 369 0.079
response to oxygen levels GO:0070482 100 0.078
cellular response to oxygen containing compound GO:1901701 276 0.078
positive regulation of wnt signaling pathway GO:0030177 54 0.078
positive regulation of cellular component organization GO:0051130 376 0.077
regulation of protein complex assembly GO:0043254 147 0.077
positive regulation of cell cycle process GO:0090068 106 0.076
response to organonitrogen compound GO:0010243 156 0.076
nuclear transport GO:0051169 179 0.075
positive regulation of cell proliferation GO:0008284 301 0.074
chemotaxis GO:0006935 157 0.073
mitotic cell cycle checkpoint GO:0007093 68 0.072
Yeast Fly
signal transduction by phosphorylation GO:0023014 297 0.072
organophosphate catabolic process GO:0046434 430 0.072
female gamete generation GO:0007292 2 0.071
hemopoiesis GO:0030097 180 0.071
Mouse
positive regulation of intracellular protein transport GO:0090316 76 0.071
stem cell differentiation GO:0048863 93 0.070
regulation of protein localization to nucleus GO:1900180 85 0.069
chromosome separation GO:0051304 23 0.069
viral process GO:0016032 146 0.068
cell projection organization GO:0030030 252 0.067
mitotic sister chromatid separation GO:0051306 18 0.066
regulation of cytoplasmic transport GO:1903649 149 0.066
organ morphogenesis GO:0009887 147 0.065
locomotory behavior GO:0007626 1 0.064
reproductive structure development GO:0048608 55 0.064
dna replication GO:0006260 116 0.064
Yeast
regulation of cytoskeleton organization GO:0051493 177 0.063
myeloid cell differentiation GO:0030099 117 0.063
chromosome segregation GO:0007059 114 0.060
regulation of establishment of protein localization GO:0070201 242 0.060
response to lipid GO:0033993 206 0.059
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.058
organelle fission GO:0048285 149 0.058
Yeast Fly
regulation of cell differentiation GO:0045595 393 0.057
chromatin remodeling GO:0006338 55 0.057
Yeast
anatomical structure formation involved in morphogenesis GO:0048646 284 0.057
reciprocal dna recombination GO:0035825 4 0.056
Yeast
cell morphogenesis GO:0000902 296 0.056
intrinsic apoptotic signaling pathway GO:0097193 127 0.055
maintenance of location in cell GO:0051651 62 0.055
multi organism cellular process GO:0044764 156 0.055
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.054
nuclear migration GO:0007097 1 0.054
intracellular protein transport GO:0006886 270 0.054
regulation of protein processing GO:0070613 150 0.054
regulation of response to dna damage stimulus GO:2001020 94 0.054
regulation of cellular component movement GO:0051270 334 0.053
positive regulation of cytoplasmic transport GO:1903651 82 0.053
regulation of mitosis GO:0007088 63 0.053
ras protein signal transduction GO:0007265 73 0.053
angiogenesis GO:0001525 147 0.052
purine ribonucleoside metabolic process GO:0046128 437 0.051
single organism reproductive process GO:0044702 98 0.051
histone modification GO:0016570 251 0.051
mitotic spindle organization GO:0007052 27 0.050
Fly
macromolecule methylation GO:0043414 97 0.050
negative regulation of cell differentiation GO:0045596 171 0.050
nucleus organization GO:0006997 28 0.050
regulation of intracellular protein transport GO:0033157 123 0.050
neuron differentiation GO:0030182 138 0.048
regulation of binding GO:0051098 111 0.048
determination of adult lifespan GO:0008340 2 0.048
kinetochore organization GO:0051383 8 0.048
positive regulation of proteolysis GO:0045862 142 0.047
protein localization to organelle GO:0033365 280 0.047
positive regulation of cell development GO:0010720 92 0.047
cell part morphogenesis GO:0032990 137 0.047
mitotic cytokinesis GO:0000281 19 0.047
response to nitrogen compound GO:1901698 184 0.047
positive regulation of protein import into nucleus GO:0042307 46 0.046
negative regulation of programmed cell death GO:0043069 321 0.046
regulation of gene expression epigenetic GO:0040029 73 0.046
Worm Fly
negative regulation of organelle organization GO:0010639 126 0.045
dna ligation involved in dna repair GO:0051103 4 0.045
gland development GO:0048732 48 0.045
protein depolymerization GO:0051261 30 0.045
cell projection morphogenesis GO:0048858 129 0.044
protein processing GO:0016485 226 0.043
response to oxidative stress GO:0006979 121 0.043
response to hormone GO:0009725 175 0.042
cytoplasmic transport GO:0016482 379 0.042
mitotic spindle midzone assembly GO:0051256 4 0.041
dephosphorylation GO:0016311 209 0.041
positive regulation of programmed cell death GO:0043068 249 0.041
regulation of nervous system development GO:0051960 88 0.041
microtubule anchoring GO:0034453 24 0.040
negative regulation of protein metabolic process GO:0051248 391 0.040
small gtpase mediated signal transduction GO:0007264 78 0.040
sister chromatid biorientation GO:0031134 2 0.039
development of primary male sexual characteristics GO:0046546 23 0.039
epithelium development GO:0060429 227 0.039
chordate embryonic development GO:0043009 34 0.039
regulation of microtubule polymerization or depolymerization GO:0031110 27 0.039
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.038
regulation of protein transport GO:0051223 213 0.038
heart development GO:0007507 95 0.038
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.038
oocyte development GO:0048599 1 0.038
protein polymerization GO:0051258 71 0.037
regulation of transferase activity GO:0051338 355 0.037
cell morphogenesis involved in differentiation GO:0000904 144 0.037
spindle checkpoint GO:0031577 26 0.037
response to alcohol GO:0097305 64 0.036
enzyme linked receptor protein signaling pathway GO:0007167 303 0.036
mitotic dna integrity checkpoint GO:0044774 30 0.036
Yeast Fly
regulation of microtubule based process GO:0032886 74 0.036
developmental process involved in reproduction GO:0003006 66 0.036
microtubule based movement GO:0007018 32 0.035
methylation GO:0032259 106 0.035
tissue morphogenesis GO:0048729 96 0.035
actin filament based process GO:0030029 224 0.035
response to radiation GO:0009314 151 0.035
regulation of kinase activity GO:0043549 314 0.034
stem cell division GO:0017145 2 0.034
protein maturation GO:0051604 233 0.034
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.033
multicellular organismal aging GO:0010259 3 0.033
taxis GO:0042330 157 0.033
positive regulation of cellular catabolic process GO:0031331 284 0.033
positive regulation of protein kinase activity GO:0045860 190 0.032
regulation of protein kinase activity GO:0045859 289 0.032
neuron projection morphogenesis GO:0048812 50 0.032
response to uv GO:0009411 73 0.032
maintenance of protein location GO:0045185 57 0.031
neuron development GO:0048666 113 0.031
regulation of cell motility GO:2000145 299 0.031
positive regulation of neural precursor cell proliferation GO:2000179 2 0.031
forebrain development GO:0030900 26 0.031
negative regulation of developmental process GO:0051093 247 0.031
response to hypoxia GO:0001666 96 0.031
regulation of cellular component biogenesis GO:0044087 281 0.031
regulation of cell migration GO:0030334 289 0.031
response to other organism GO:0051707 261 0.030
maintenance of protein location in cell GO:0032507 56 0.030
gene silencing GO:0016458 49 0.030
Worm Fly
peptidyl tyrosine phosphorylation GO:0018108 170 0.030
spindle midzone assembly GO:0051255 4 0.030
response to light stimulus GO:0009416 87 0.029
regulation of myeloid cell differentiation GO:0045637 81 0.029
negative regulation of protein maturation GO:1903318 142 0.029
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.029
cellular response to external stimulus GO:0071496 111 0.029
regulation of intracellular transport GO:0032386 195 0.028
brain development GO:0007420 97 0.028
regulation of neurogenesis GO:0050767 82 0.028
head development GO:0060322 108 0.028
mitotic chromosome condensation GO:0007076 11 0.028
Fly
base excision repair GO:0006284 21 0.027
mapk cascade GO:0000165 288 0.027
negative regulation of cell division GO:0051782 31 0.027
positive regulation of hydrolase activity GO:0051345 331 0.027
mitotic spindle checkpoint GO:0071174 18 0.027
response to wounding GO:0009611 168 0.027
cellular component disassembly GO:0022411 92 0.027
cellular protein catabolic process GO:0044257 261 0.026
positive regulation of cell death GO:0010942 263 0.026
negative regulation of multicellular organismal process GO:0051241 317 0.026
positive regulation of transport GO:0051050 336 0.026
endomembrane system organization GO:0010256 196 0.025
regulation of epithelial cell proliferation GO:0050678 113 0.025
negative regulation of microtubule polymerization or depolymerization GO:0031111 17 0.025
response to drug GO:0042493 81 0.025
eye photoreceptor cell differentiation GO:0001754 2 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.025
blood vessel morphogenesis GO:0048514 162 0.025
embryo development ending in birth or egg hatching GO:0009792 34 0.025
Worm
spindle assembly GO:0051225 29 0.024
apoptotic signaling pathway GO:0097190 268 0.024
oocyte differentiation GO:0009994 2 0.024
regulation of dna binding GO:0051101 37 0.024
dna damage checkpoint GO:0000077 68 0.024
Fly
response to steroid hormone GO:0048545 80 0.024
positive regulation of cell differentiation GO:0045597 211 0.024
reproductive process GO:0022414 106 0.024
double strand break repair via nonhomologous end joining GO:0006303 10 0.024
negative regulation of chromosome organization GO:2001251 48 0.024
microtubule cytoskeleton organization involved in mitosis GO:1902850 15 0.023
regulation of multi organism process GO:0043900 157 0.023
protein homooligomerization GO:0051260 100 0.023
positive regulation of nucleocytoplasmic transport GO:0046824 54 0.023
negative regulation of transcription initiation from rna polymerase ii promoter GO:0060633 3 0.023
positive regulation of protein localization to nucleus GO:1900182 48 0.022
cellular amino acid metabolic process GO:0006520 116 0.022
cellular response to hormone stimulus GO:0032870 125 0.022
positive regulation of mitosis GO:0045840 25 0.022
male meiosis GO:0007140 1 0.022
regulation of protein stability GO:0031647 87 0.022
regulation of microtubule cytoskeleton organization GO:0070507 61 0.021
vasculature development GO:0001944 181 0.021
regulation of locomotion GO:0040012 329 0.021
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.021
regulation of cell morphogenesis GO:0022604 153 0.021
membrane organization GO:0061024 292 0.020
negative regulation of nervous system development GO:0051961 28 0.020
response to biotic stimulus GO:0009607 276 0.020
regulation of nuclear division GO:0051783 65 0.020
non recombinational repair GO:0000726 14 0.020
negative regulation of phosphorus metabolic process GO:0010563 267 0.020
developmental growth GO:0048589 48 0.020
reproduction GO:0000003 63 0.020
Yeast Worm
regulation of protein serine threonine kinase activity GO:0071900 179 0.020
regulation of peptidase activity GO:0052547 180 0.020
microtubule organizing center organization GO:0031023 62 0.020
brain morphogenesis GO:0048854 1 0.019
development of primary sexual characteristics GO:0045137 35 0.019
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 35 0.019
regulation of defense response GO:0031347 154 0.019
regulation of dna replication GO:0006275 68 0.019
Yeast
positive regulation of multi organism process GO:0043902 56 0.019
somatic stem cell division GO:0048103 1 0.019
positive regulation of mitotic cell cycle GO:0045931 60 0.019
cell fate determination GO:0001709 3 0.019
spermatid differentiation GO:0048515 4 0.019
response to purine containing compound GO:0014074 40 0.019
v d j recombination GO:0033151 3 0.018
tissue regeneration GO:0042246 3 0.018
regulation of double strand break repair GO:2000779 22 0.018
nucleic acid phosphodiester bond hydrolysis GO:0090305 102 0.018
protein autophosphorylation GO:0046777 123 0.018
dna geometric change GO:0032392 32 0.018
Yeast
positive regulation of protein catabolic process GO:0045732 75 0.018
regulation of response to external stimulus GO:0032101 222 0.018
regulation of dephosphorylation GO:0035303 96 0.018
negative regulation of intracellular signal transduction GO:1902532 183 0.018
negative regulation of phosphate metabolic process GO:0045936 267 0.018
negative regulation of cellular protein metabolic process GO:0032269 353 0.018
cellular amine metabolic process GO:0044106 41 0.018
regulation of spindle organization GO:0090224 10 0.018
regulation of cellular ketone metabolic process GO:0010565 50 0.018
regulation of sister chromatid segregation GO:0033045 27 0.017
negative regulation of catalytic activity GO:0043086 335 0.017
response to external biotic stimulus GO:0043207 261 0.017
regulation of cell adhesion GO:0030155 166 0.017
reproductive system development GO:0061458 56 0.017
epithelial cell differentiation GO:0030855 141 0.017
hematopoietic progenitor cell differentiation GO:0002244 38 0.016
Mouse
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.016
cellular response to lipid GO:0071396 127 0.016
neuron projection development GO:0031175 106 0.016
signal transduction involved in regulation of gene expression GO:0023019 1 0.016
regulation of cellular amino acid metabolic process GO:0006521 6 0.016
positive regulation of myeloid cell differentiation GO:0045639 39 0.016
regulation of ras protein signal transduction GO:0046578 155 0.016
muscle tissue development GO:0060537 62 0.016
regulation of canonical wnt signaling pathway GO:0060828 88 0.016
positive regulation of dna metabolic process GO:0051054 73 0.016
regulation of mitotic recombination GO:0000019 1 0.016
Yeast
positive regulation of cell division GO:0051781 59 0.016
cell cycle g2 m phase transition GO:0044839 43 0.016
response to nutrient levels GO:0031667 81 0.016
spermatid development GO:0007286 4 0.015
single organism carbohydrate metabolic process GO:0044723 193 0.015
dna integrity checkpoint GO:0031570 71 0.015
Yeast Fly
regulation of cellular protein catabolic process GO:1903362 96 0.015
positive regulation of immune response GO:0050778 159 0.015
stem cell development GO:0048864 69 0.015
regulation of protein maturation GO:1903317 150 0.015
regulation of neuron differentiation GO:0045664 70 0.015
central nervous system development GO:0007417 123 0.015
response to extracellular stimulus GO:0009991 85 0.015
positive regulation of nervous system development GO:0051962 54 0.015
negative regulation of gene expression epigenetic GO:0045814 19 0.014
Fly
cell growth GO:0016049 160 0.014
immune response GO:0006955 307 0.014
macromolecular complex disassembly GO:0032984 60 0.014
viral life cycle GO:0019058 132 0.014
wound healing GO:0042060 115 0.014
regulation of immune response GO:0050776 201 0.014
mesenchymal cell development GO:0014031 50 0.014
negative regulation of protein phosphorylation GO:0001933 140 0.014
cellular response to nitrogen compound GO:1901699 144 0.014
protein complex disassembly GO:0043241 52 0.014
cellular response to organonitrogen compound GO:0071417 124 0.014
morphogenesis of an epithelium GO:0002009 60 0.013
positive regulation of immune system process GO:0002684 283 0.013
negative regulation of protein complex disassembly GO:0043242 20 0.013
striated muscle tissue development GO:0014706 59 0.013
negative regulation of protein catabolic process GO:0042177 59 0.013
protein ubiquitination GO:0016567 314 0.013
cellular response to extracellular stimulus GO:0031668 72 0.013
cytokinesis completion of separation GO:0007109 3 0.013
neuronal stem cell division GO:0036445 1 0.013
secretion by cell GO:0032940 226 0.013
positive regulation of proteasomal protein catabolic process GO:1901800 35 0.013
positive regulation of kinase activity GO:0033674 204 0.013
negative regulation of transport GO:0051051 176 0.013
cellular protein complex disassembly GO:0043624 36 0.013
response to axon injury GO:0048678 1 0.013
negative regulation of multi organism process GO:0043901 92 0.013
posttranscriptional regulation of gene expression GO:0010608 213 0.012
Worm
response to inorganic substance GO:0010035 127 0.012
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 29 0.012
regulation of mitotic spindle organization GO:0060236 6 0.012
regulation of dna repair GO:0006282 47 0.012
positive regulation of chromosome organization GO:2001252 41 0.012
epithelial cell proliferation GO:0050673 128 0.012
regulation of chromatin modification GO:1903308 51 0.012
regulation of cell morphogenesis involved in differentiation GO:0010769 83 0.012
ventricular cardiac muscle cell differentiation GO:0055012 1 0.012
inflammatory response GO:0006954 79 0.012
embryonic placenta development GO:0001892 1 0.012
cytokinetic process GO:0032506 12 0.012
rna polymerase ii transcriptional preinitiation complex assembly GO:0051123 4 0.012
positive regulation of nucleotide catabolic process GO:0030813 185 0.012
meiotic cell cycle GO:0051321 13 0.011
Yeast
positive regulation of apoptotic process GO:0043065 246 0.011
regulation of mitotic sister chromatid separation GO:0010965 27 0.011
g2 m transition of mitotic cell cycle GO:0000086 41 0.011
ribosome assembly GO:0042255 9 0.011
cell activation involved in immune response GO:0002263 30 0.011
ossification GO:0001503 121 0.011
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.011
cellular ketone metabolic process GO:0042180 80 0.011
negative regulation of protein processing GO:0010955 142 0.011
establishment or maintenance of cell polarity GO:0007163 31 0.011
mitotic spindle assembly checkpoint GO:0007094 14 0.011
somatic diversification of immune receptors via somatic mutation GO:0002566 1 0.011
regulation of apoptotic signaling pathway GO:2001233 175 0.011
attachment of spindle microtubules to kinetochore GO:0008608 17 0.011
positive regulation of transferase activity GO:0051347 227 0.011
multi organism reproductive process GO:0044703 54 0.011
circulatory system process GO:0003013 113 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.010
positive regulation of protein complex assembly GO:0031334 86 0.010
lipid catabolic process GO:0016042 84 0.010
response to growth factor GO:0070848 205 0.010
cellular response to oxidative stress GO:0034599 85 0.010
regulation of purine nucleotide metabolic process GO:1900542 264 0.010
centrosome cycle GO:0007098 32 0.010
cellular response to reactive oxygen species GO:0034614 50 0.010

TOP2A disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 174 0.160
cancer DOID:162 167 0.074
organ system cancer DOID:0050686 164 0.074
thoracic cancer DOID:5093 21 0.016
physical disorder DOID:0080015 41 0.016
breast cancer DOID:1612 21 0.012