Homo sapiens

110 known processes

TOPORS

topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase

(Aliases: TP53BPL,P53BP3,RP31,LUN)

TOPORS biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation GO:0032446 342 0.964
protein ubiquitination GO:0016567 314 0.787
ubiquitin dependent protein catabolic process GO:0006511 206 0.690
cellular protein catabolic process GO:0044257 261 0.573
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.550
modification dependent macromolecule catabolic process GO:0043632 212 0.513
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.421
protein polyubiquitination GO:0000209 110 0.408
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.389
modification dependent protein catabolic process GO:0019941 209 0.334
cellular response to dna damage stimulus GO:0006974 379 0.284
chromatin modification GO:0016568 298 0.262
proteasomal protein catabolic process GO:0010498 176 0.261
i kappab kinase nf kappab signaling GO:0007249 166 0.243
regulation of cell cycle GO:0051726 393 0.237
Fly
cellular amino acid metabolic process GO:0006520 116 0.200
positive regulation of cell death GO:0010942 263 0.181
cellular macromolecule catabolic process GO:0044265 380 0.180
negative regulation of cell death GO:0060548 345 0.171
protein catabolic process GO:0030163 325 0.158
negative regulation of apoptotic process GO:0043066 316 0.153
negative regulation of catalytic activity GO:0043086 335 0.140
positive regulation of i kappab kinase nf kappab signaling GO:0043123 132 0.136
amine metabolic process GO:0009308 44 0.131
positive regulation of programmed cell death GO:0043068 249 0.125
histone ubiquitination GO:0016574 31 0.120
regulation of cellular response to stress GO:0080135 244 0.118
androgen receptor signaling pathway GO:0030521 34 0.114
intracellular steroid hormone receptor signaling pathway GO:0030518 61 0.104
regulation of i kappab kinase nf kappab signaling GO:0043122 162 0.101
regulation of apoptotic signaling pathway GO:2001233 175 0.092
protein processing GO:0016485 226 0.089
regulation of cellular ketone metabolic process GO:0010565 50 0.088
protein glycosylation GO:0006486 62 0.086
regulation of proteolysis GO:0030162 293 0.086
neural tube formation GO:0001841 3 0.085
regulation of intrinsic apoptotic signaling pathway GO:2001242 72 0.084
morphogenesis of embryonic epithelium GO:0016331 4 0.081
intracellular receptor signaling pathway GO:0030522 104 0.078
embryonic epithelial tube formation GO:0001838 4 0.077
negative regulation of protein metabolic process GO:0051248 391 0.072
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.068
macromolecule methylation GO:0043414 97 0.068
regulation of cellular component biogenesis GO:0044087 281 0.067
nervous system development GO:0007399 293 0.067
negative regulation of programmed cell death GO:0043069 321 0.065
negative regulation of protein maturation GO:1903318 142 0.064
protein maturation GO:0051604 233 0.064
regulation of cellular amine metabolic process GO:0033238 11 0.062
dna repair GO:0006281 198 0.061
extrinsic apoptotic signaling pathway GO:0097191 119 0.061
interspecies interaction between organisms GO:0044419 156 0.060
regulation of anatomical structure morphogenesis GO:0022603 286 0.059
protein autoubiquitination GO:0051865 37 0.059
post embryonic development GO:0009791 2 0.059
cellular ketone metabolic process GO:0042180 80 0.058
mitotic cell cycle phase transition GO:0044772 162 0.055
Fly
negative regulation of proteolysis GO:0045861 132 0.054
carbohydrate derivative biosynthetic process GO:1901137 207 0.054
regulation of kinase activity GO:0043549 314 0.054
vesicle mediated transport GO:0016192 371 0.053
regulation of endopeptidase activity GO:0052548 170 0.053
regulation of protein processing GO:0070613 150 0.052
apoptotic signaling pathway GO:0097190 268 0.051
response to radiation GO:0009314 151 0.050
regulation of chromosome organization GO:0033044 103 0.049
covalent chromatin modification GO:0016569 254 0.049
system process GO:0003008 349 0.048
regulation of mitotic cell cycle GO:0007346 189 0.048
Fly
positive regulation of apoptotic process GO:0043065 246 0.047
viral process GO:0016032 146 0.046
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.045
histone modification GO:0016570 251 0.045
negative regulation of endopeptidase activity GO:0010951 84 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.044
positive regulation of organelle organization GO:0010638 195 0.043
response to abiotic stimulus GO:0009628 336 0.043
positive regulation of cellular component organization GO:0051130 376 0.042
protein oligomerization GO:0051259 173 0.042
positive regulation of catabolic process GO:0009896 310 0.042
dna templated transcription initiation GO:0006352 35 0.042
negative regulation of cellular protein metabolic process GO:0032269 353 0.041
regulation of cysteine type endopeptidase activity GO:2000116 127 0.041
intrinsic apoptotic signaling pathway GO:0097193 127 0.040
regulation of response to dna damage stimulus GO:2001020 94 0.040
cellular response to lipid GO:0071396 127 0.039
cellular amine metabolic process GO:0044106 41 0.039
determination of adult lifespan GO:0008340 2 0.039
leukocyte apoptotic process GO:0071887 31 0.039
viral release from host cell GO:0019076 21 0.039
carbohydrate metabolic process GO:0005975 207 0.039
positive regulation of wnt signaling pathway GO:0030177 54 0.039
negative regulation of protein processing GO:0010955 142 0.038
signal transduction by phosphorylation GO:0023014 297 0.038
regulation of sequence specific dna binding transcription factor activity GO:0051090 211 0.037
positive regulation of cellular amine metabolic process GO:0033240 7 0.037
negative regulation of cell proliferation GO:0008285 228 0.037
regulation of transcription by chromatin organization GO:0034401 1 0.037
regulation of cell cycle process GO:0010564 266 0.036
Fly
nucleoside monophosphate metabolic process GO:0009123 191 0.036
ribonucleoside triphosphate catabolic process GO:0009203 391 0.036
negative regulation of cellular amine metabolic process GO:0033239 3 0.035
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 37 0.035
Fly
regulation of viral process GO:0050792 103 0.035
positive regulation of proteolysis GO:0045862 142 0.035
response to lipid GO:0033993 206 0.034
negative regulation of apoptotic signaling pathway GO:2001234 97 0.034
positive regulation of cell differentiation GO:0045597 211 0.034
negative regulation of cell development GO:0010721 48 0.033
multicellular organismal aging GO:0010259 3 0.033
negative regulation of transferase activity GO:0051348 124 0.032
positive regulation of apoptotic signaling pathway GO:2001235 70 0.031
establishment or maintenance of apical basal cell polarity GO:0035088 2 0.031
regulation of protein ubiquitination GO:0031396 95 0.030
cellular response to cytokine stimulus GO:0071345 181 0.030
regulation of intracellular steroid hormone receptor signaling pathway GO:0033143 32 0.030
regulation of protein catabolic process GO:0042176 155 0.030
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 109 0.029
somitogenesis GO:0001756 2 0.029
ribonucleoside monophosphate metabolic process GO:0009161 187 0.027
glycoprotein metabolic process GO:0009100 110 0.027
negative regulation of phosphorylation GO:0042326 174 0.027
regulation of wnt signaling pathway GO:0030111 123 0.027
circulatory system development GO:0072359 262 0.026
wnt signaling pathway GO:0016055 156 0.026
memory GO:0007613 3 0.026
regulation of response to external stimulus GO:0032101 222 0.025
inflammatory response GO:0006954 79 0.025
regulation of protein maturation GO:1903317 150 0.025
long term memory GO:0007616 2 0.025
female gamete generation GO:0007292 2 0.025
negative regulation of kinase activity GO:0033673 106 0.025
neurogenesis GO:0022008 169 0.024
cellular response to oxygen containing compound GO:1901701 276 0.024
positive regulation of cellular catabolic process GO:0031331 284 0.024
positive regulation of sequence specific dna binding transcription factor activity GO:0051091 131 0.024
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.024
negative regulation of cellular component organization GO:0051129 235 0.024
positive regulation of developmental process GO:0051094 314 0.024
defense response GO:0006952 315 0.023
response to organic cyclic compound GO:0014070 204 0.023
cell projection organization GO:0030030 252 0.023
regulation of autophagy GO:0010506 52 0.023
regulation of cellular amino acid metabolic process GO:0006521 6 0.023
purine ribonucleoside monophosphate metabolic process GO:0009167 186 0.023
positive regulation of transport GO:0051050 336 0.023
canonical wnt signaling pathway GO:0060070 116 0.022
negative regulation of transport GO:0051051 176 0.022
negative regulation of phosphate metabolic process GO:0045936 267 0.022
histone h3 acetylation GO:0043966 45 0.022
actin cytoskeleton organization GO:0030036 207 0.021
dna damage checkpoint GO:0000077 68 0.021
Fly
positive regulation of chromosome organization GO:2001252 41 0.021
negative regulation of binding GO:0051100 57 0.021
forelimb morphogenesis GO:0035136 4 0.020
response to hormone GO:0009725 175 0.020
regulation of chromatin modification GO:1903308 51 0.020
regulation of mitotic cell cycle phase transition GO:1901990 118 0.020
Fly
negative regulation of hydrolase activity GO:0051346 182 0.020
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.020
Fly
multi organism cellular process GO:0044764 156 0.020
regulation of defense response GO:0031347 154 0.020
locomotory behavior GO:0007626 1 0.020
response to tumor necrosis factor GO:0034612 76 0.019
endocytosis GO:0006897 159 0.019
peptidyl tyrosine phosphorylation GO:0018108 170 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 411 0.019
cellular response to endogenous stimulus GO:0071495 336 0.019
regulation of gene expression epigenetic GO:0040029 73 0.019
growth GO:0040007 202 0.019
regulation of protein stability GO:0031647 87 0.019
response to alcohol GO:0097305 64 0.019
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.019
regulation of histone modification GO:0031056 47 0.019
stress activated mapk cascade GO:0051403 93 0.019
negative regulation of cell cycle GO:0045786 193 0.019
Fly
cytoplasmic transport GO:0016482 379 0.018
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 40 0.018
regulation of peptidase activity GO:0052547 180 0.018
positive regulation of canonical wnt signaling pathway GO:0090263 33 0.018
dna integrity checkpoint GO:0031570 71 0.018
Fly
glycosylation GO:0070085 71 0.018
microtubule based process GO:0007017 210 0.018
Fly
protein targeting GO:0006605 187 0.018
blood vessel morphogenesis GO:0048514 162 0.018
protein localization to organelle GO:0033365 280 0.017
response to oxygen containing compound GO:1901700 369 0.017
double strand break repair GO:0006302 101 0.017
cell morphogenesis GO:0000902 296 0.017
rna interference GO:0016246 4 0.017
negative regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043154 46 0.017
tube morphogenesis GO:0035239 95 0.017
negative regulation of chromosome organization GO:2001251 48 0.017
positive regulation of response to dna damage stimulus GO:2001022 43 0.017
negative regulation of protein modification process GO:0031400 200 0.017
negative regulation of peptidase activity GO:0010466 91 0.017
neurological system process GO:0050877 163 0.017
regulation of protein localization GO:0032880 296 0.017
atp metabolic process GO:0046034 176 0.016
cellular response to abiotic stimulus GO:0071214 117 0.016
actin filament based process GO:0030029 224 0.016
positive regulation of viral process GO:0048524 37 0.016
negative regulation of intracellular signal transduction GO:1902532 183 0.016
negative regulation of multicellular organismal process GO:0051241 317 0.016
glycoprotein biosynthetic process GO:0009101 91 0.016
response to ionizing radiation GO:0010212 65 0.016
cell cycle checkpoint GO:0000075 117 0.016
Fly
regulation of mapk cascade GO:0043408 262 0.016
neuromuscular junction development GO:0007528 3 0.016
cytokine mediated signaling pathway GO:0019221 109 0.016
organophosphate catabolic process GO:0046434 430 0.016
negative regulation of cysteine type endopeptidase activity GO:2000117 48 0.016
negative regulation of growth GO:0045926 97 0.016
positive regulation of phosphorylation GO:0042327 394 0.016
cellular response to organic cyclic compound GO:0071407 127 0.016
regulation of cellular protein catabolic process GO:1903362 96 0.015
peptidyl tyrosine modification GO:0018212 170 0.015
oocyte development GO:0048599 1 0.015
mapk cascade GO:0000165 288 0.015
regulation of dna repair GO:0006282 47 0.015
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 69 0.015
positive regulation of histone modification GO:0031058 29 0.015
regulation of protein complex assembly GO:0043254 147 0.015
anatomical structure formation involved in morphogenesis GO:0048646 284 0.015
negative regulation of phosphorus metabolic process GO:0010563 267 0.015
tube closure GO:0060606 3 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.014
regulation of anatomical structure size GO:0090066 101 0.014
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.014
Mouse
hemopoiesis GO:0030097 180 0.014
negative regulation of cellular response to oxidative stress GO:1900408 18 0.014
immune response GO:0006955 307 0.014
mitotic cell cycle process GO:1903047 286 0.014
Fly
regulation of canonical wnt signaling pathway GO:0060828 88 0.014
regulation of extrinsic apoptotic signaling pathway GO:2001236 85 0.014
microtubule cytoskeleton organization GO:0000226 176 0.014
Fly
cellular response to nitrogen compound GO:1901699 144 0.014
tube development GO:0035295 125 0.014
purine nucleotide catabolic process GO:0006195 405 0.014
cell growth GO:0016049 160 0.014
response to lipopolysaccharide GO:0032496 70 0.014
regulation of neural precursor cell proliferation GO:2000177 4 0.014
cellular response to extracellular stimulus GO:0031668 72 0.014
cellular response to external stimulus GO:0071496 111 0.013
positive regulation of immune response GO:0050778 159 0.013
secretion by cell GO:0032940 226 0.013
blood vessel development GO:0001568 172 0.013
nitrogen compound transport GO:0071705 191 0.013
purine ribonucleotide catabolic process GO:0009154 404 0.013
regulation of membrane potential GO:0042391 95 0.013
innate immune response GO:0045087 178 0.013
negative regulation of secretion by cell GO:1903531 52 0.013
response to other organism GO:0051707 261 0.013
stress activated protein kinase signaling cascade GO:0031098 94 0.013
regulation of cytoplasmic transport GO:1903649 149 0.013
positive regulation of multi organism process GO:0043902 56 0.013
positive regulation of immune system process GO:0002684 283 0.013
regulation of viral transcription GO:0046782 34 0.013
ribonucleoside triphosphate metabolic process GO:0009199 412 0.013
response to wounding GO:0009611 168 0.013
purine ribonucleoside metabolic process GO:0046128 437 0.013
response to biotic stimulus GO:0009607 276 0.013
cardiovascular system development GO:0072358 262 0.013
response to external biotic stimulus GO:0043207 261 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.013
chromatin organization GO:0006325 351 0.012
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 21 0.012
regulation of proteasomal protein catabolic process GO:0061136 87 0.012
vasculature development GO:0001944 181 0.012
positive regulation of synaptic transmission GO:0050806 4 0.012
circadian sleep wake cycle sleep GO:0050802 2 0.012
nucleoside triphosphate metabolic process GO:0009141 422 0.012
regulation of intracellular transport GO:0032386 195 0.012
methylation GO:0032259 106 0.012
atp catabolic process GO:0006200 157 0.012
cell cycle phase transition GO:0044770 173 0.012
Fly
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.012
regulation of dna metabolic process GO:0051052 153 0.012
cellular response to hormone stimulus GO:0032870 125 0.012
response to bacterium GO:0009617 144 0.012
response to oxidative stress GO:0006979 121 0.012
response to extracellular stimulus GO:0009991 85 0.012
associative learning GO:0008306 1 0.012
neurotransmitter secretion GO:0007269 4 0.011
negative regulation of cell growth GO:0030308 83 0.011
purine nucleoside monophosphate catabolic process GO:0009128 158 0.011
response to nitrogen compound GO:1901698 184 0.011
regulation of oxidative stress induced cell death GO:1903201 24 0.011
response to cytokine GO:0034097 232 0.011
regulation of secretion by cell GO:1903530 177 0.011
positive regulation of cysteine type endopeptidase activity GO:2001056 79 0.011
neuroblast proliferation GO:0007405 4 0.011
mitotic sister chromatid segregation GO:0000070 53 0.011
positive regulation of cell cycle GO:0045787 140 0.011
cellular homeostasis GO:0019725 196 0.011
purine containing compound catabolic process GO:0072523 411 0.011
jnk cascade GO:0007254 80 0.011
oogenesis GO:0048477 2 0.011
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 156 0.011
histone exchange GO:0043486 3 0.011
positive regulation of hydrolase activity GO:0051345 331 0.011
sister chromatid segregation GO:0000819 54 0.010
regulation of multi organism process GO:0043900 157 0.010
protein alkylation GO:0008213 74 0.010
purine nucleoside triphosphate metabolic process GO:0009144 412 0.010
negative regulation of response to external stimulus GO:0032102 83 0.010
rna splicing via transesterification reactions GO:0000375 90 0.010
internal peptidyl lysine acetylation GO:0018393 97 0.010
cell type specific apoptotic process GO:0097285 125 0.010
regulation of transferase activity GO:0051338 355 0.010
organophosphate biosynthetic process GO:0090407 163 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 391 0.010
cellular component morphogenesis GO:0032989 314 0.010
ossification GO:0001503 121 0.010
nucleosome organization GO:0034728 66 0.010
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 1 0.010
nucleosome positioning GO:0016584 3 0.010

TOPORS disease predictions

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 167 0.086
disease of cellular proliferation DOID:14566 174 0.086
organ system cancer DOID:0050686 164 0.086
gastrointestinal system cancer DOID:3119 52 0.014
bone disease DOID:0080001 88 0.013
musculoskeletal system disease DOID:17 223 0.013
connective tissue disease DOID:65 109 0.013
breast cancer DOID:1612 21 0.012
thoracic cancer DOID:5093 21 0.012
sensory system disease DOID:0050155 203 0.011
eye and adnexa disease DOID:1492 150 0.011
nervous system disease DOID:863 431 0.011
eye disease DOID:5614 149 0.005
retinal disease DOID:5679 118 0.005
retinal degeneration DOID:8466 89 0.005
retinitis pigmentosa DOID:10584 51 0.005