Homo sapiens

71 known processes

TP53BP1

tumor protein p53 binding protein 1

(Aliases: 53BP1,p202,FLJ41424,MGC138366)

TP53BP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
covalent chromatin modification GO:0016569 254 0.965
histone modification GO:0016570 251 0.951
cellular response to dna damage stimulus GO:0006974 379 0.896
response to radiation GO:0009314 151 0.849
chromatin modification GO:0016568 298 0.844
chromatin organization GO:0006325 351 0.772
response to abiotic stimulus GO:0009628 336 0.583
response to ionizing radiation GO:0010212 65 0.563
cell cycle checkpoint GO:0000075 117 0.462
immune system development GO:0002520 195 0.431
positive regulation of immunoglobulin mediated immune response GO:0002891 4 0.425
somatic diversification of immunoglobulins involved in immune response GO:0002208 3 0.422
negative regulation of megakaryocyte differentiation GO:0045653 16 0.417
positive regulation of developmental process GO:0051094 314 0.388
v d j recombination GO:0033151 3 0.374
regulation of mitotic cell cycle GO:0007346 189 0.369
protein ubiquitination GO:0016567 314 0.322
double strand break repair GO:0006302 101 0.309
photoreceptor cell maintenance GO:0045494 13 0.285
chromatin assembly GO:0031497 61 0.283
negative regulation of mitotic cell cycle phase transition GO:1901991 85 0.279
signal transduction in response to dna damage GO:0042770 57 0.273
ubiquitin dependent protein catabolic process GO:0006511 206 0.262
dna damage response signal transduction by p53 class mediator GO:0030330 44 0.252
negative regulation of cell cycle process GO:0010948 121 0.249
histone lysine methylation GO:0034968 50 0.243
positive regulation of dna repair GO:0045739 25 0.240
regulation of dna metabolic process GO:0051052 153 0.234
regulation of cell cycle GO:0051726 393 0.230
detection of muramyl dipeptide GO:0032498 1 0.228
protein catabolic process GO:0030163 325 0.225
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.223
regulation of response to dna damage stimulus GO:2001020 94 0.216
negative regulation of cell cycle phase transition GO:1901988 89 0.214
immune response GO:0006955 307 0.201
histone methylation GO:0016571 60 0.198
mitotic cell cycle checkpoint GO:0007093 68 0.194
modification dependent macromolecule catabolic process GO:0043632 212 0.191
macromolecule methylation GO:0043414 97 0.189
cellular protein catabolic process GO:0044257 261 0.183
histone h2a ubiquitination GO:0033522 17 0.182
segmentation GO:0035282 4 0.181
modification dependent protein catabolic process GO:0019941 209 0.177
oocyte differentiation GO:0009994 2 0.172
cellular ketone metabolic process GO:0042180 80 0.172
internal protein amino acid acetylation GO:0006475 101 0.168
oocyte development GO:0048599 1 0.166
anatomical structure formation involved in morphogenesis GO:0048646 284 0.165
regulation of proteolysis GO:0030162 293 0.163
negative regulation of protein maturation GO:1903318 142 0.163
mitotic cell cycle phase transition GO:0044772 162 0.160
protein modification by small protein conjugation GO:0032446 342 0.160
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.157
somatic recombination of immunoglobulin gene segments GO:0016447 4 0.153
regulation of cell differentiation GO:0045595 393 0.148
telomere capping GO:0016233 5 0.144
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 71 0.143
dna replication dependent nucleosome assembly GO:0006335 32 0.142
dna repair GO:0006281 198 0.137
Mouse
negative regulation of cellular component organization GO:0051129 235 0.136
negative regulation of cellular protein catabolic process GO:1903363 38 0.133
response to biotic stimulus GO:0009607 276 0.132
regulation of cellular ketone metabolic process GO:0010565 50 0.132
regulation of double strand break repair GO:2000779 22 0.132
dna replication dependent nucleosome organization GO:0034723 32 0.131
protein alkylation GO:0008213 74 0.131
histone h3 k4 methylation GO:0051568 27 0.130
dna damage induced protein phosphorylation GO:0006975 5 0.130
somatic recombination of immunoglobulin genes involved in immune response GO:0002204 3 0.126
protein maturation GO:0051604 233 0.126
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.126
phosphatidylinositol 3 phosphate biosynthetic process GO:0036092 3 0.123
regulation of protein processing GO:0070613 150 0.122
transcription initiation from rna polymerase ii promoter GO:0006367 27 0.120
dna double strand break processing GO:0000729 10 0.119
negative regulation of protein processing GO:0010955 142 0.117
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 91 0.116
negative regulation of chromosome organization GO:2001251 48 0.114
dna damage checkpoint GO:0000077 68 0.114
single organism cellular localization GO:1902580 332 0.112
regulation of leukocyte activation GO:0002694 115 0.112
negative regulation of developmental process GO:0051093 247 0.112
histone ubiquitination GO:0016574 31 0.110
positive regulation of dna metabolic process GO:0051054 73 0.110
regulation of chromosome segregation GO:0051983 44 0.109
regulation of myeloid cell differentiation GO:0045637 81 0.108
dna replication independent nucleosome organization GO:0034724 27 0.108
positive regulation of transcription initiation from rna polymerase ii promoter GO:0060261 4 0.108
chromosome separation GO:0051304 23 0.107
ribonucleotide catabolic process GO:0009261 405 0.107
cell activation GO:0001775 213 0.105
peptidyl lysine modification GO:0018205 144 0.102
positive regulation of protein modification by small protein conjugation or removal GO:1903322 61 0.101
dna templated transcription initiation GO:0006352 35 0.100
g2 dna damage checkpoint GO:0031572 26 0.099
negative regulation of multicellular organismal process GO:0051241 317 0.098
g2 m transition of mitotic cell cycle GO:0000086 41 0.098
positive regulation of immune system process GO:0002684 283 0.098
negative regulation of transcription from rna polymerase ii promoter GO:0000122 281 0.097
chromosome segregation GO:0007059 114 0.096
regulation of cellular response to stress GO:0080135 244 0.096
regulation of immune response GO:0050776 201 0.096
cell activation involved in immune response GO:0002263 30 0.094
negative regulation of mitotic cell cycle GO:0045930 102 0.092
post embryonic development GO:0009791 2 0.092
regulation of isotype switching GO:0045191 2 0.092
female gamete generation GO:0007292 2 0.091
regulation of cell cycle phase transition GO:1901987 126 0.090
negative regulation of proteolysis GO:0045861 132 0.090
immune effector process GO:0002252 159 0.088
positive regulation of response to dna damage stimulus GO:2001022 43 0.088
protein methylation GO:0006479 74 0.087
nucleosome assembly GO:0006334 50 0.086
protein processing GO:0016485 226 0.086
regulation of protein maturation GO:1903317 150 0.085
negative regulation of hematopoietic progenitor cell differentiation GO:1901533 18 0.085
regulation of growth GO:0040008 165 0.085
response to caffeine GO:0031000 3 0.084
b cell activation GO:0042113 33 0.083
negative regulation of catabolic process GO:0009895 104 0.083
somatic diversification of immune receptors GO:0002200 8 0.083
negative regulation of cell cycle GO:0045786 193 0.083
negative regulation of organelle organization GO:0010639 126 0.082
mitotic sister chromatid segregation GO:0000070 53 0.082
small gtpase mediated signal transduction GO:0007264 78 0.081
regulation of cellular component biogenesis GO:0044087 281 0.081
myeloid cell differentiation GO:0030099 117 0.080
hindbrain development GO:0030902 3 0.080
nucleotide excision repair GO:0006289 31 0.077
regulation of lymphocyte activation GO:0051249 103 0.076
negative regulation of cellular catabolic process GO:0031330 83 0.076
cellular amino acid metabolic process GO:0006520 116 0.076
mitotic cell cycle process GO:1903047 286 0.076
negative regulation of immune system process GO:0002683 136 0.076
regulation of cellular component movement GO:0051270 334 0.074
lipid metabolic process GO:0006629 381 0.074
protein deubiquitination GO:0016579 79 0.074
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.073
ras protein signal transduction GO:0007265 73 0.073
cellular response to abiotic stimulus GO:0071214 117 0.073
regulation of mitotic cell cycle phase transition GO:1901990 118 0.071
histone h2a phosphorylation GO:1990164 3 0.070
histone acetylation GO:0016573 93 0.070
protein acylation GO:0043543 138 0.070
positive regulation of immune response GO:0050778 159 0.070
epithelium migration GO:0090132 119 0.068
positive regulation of cell activation GO:0050867 81 0.067
positive regulation of leukocyte mediated immunity GO:0002705 24 0.066
internal peptidyl lysine acetylation GO:0018393 97 0.066
leukocyte activation involved in immune response GO:0002366 30 0.066
cellular lipid metabolic process GO:0044255 303 0.065
spindle checkpoint GO:0031577 26 0.065
regulation of b cell activation GO:0050864 24 0.064
epidermis morphogenesis GO:0048730 3 0.063
organophosphate catabolic process GO:0046434 430 0.063
mitotic nuclear division GO:0007067 119 0.063
lipid biosynthetic process GO:0008610 177 0.063
regulation of protein complex assembly GO:0043254 147 0.062
positive regulation of cellular amine metabolic process GO:0033240 7 0.062
trabecula morphogenesis GO:0061383 2 0.062
cellular amine metabolic process GO:0044106 41 0.062
methylation GO:0032259 106 0.061
regulation of cellular protein catabolic process GO:1903362 96 0.060
cell cycle phase transition GO:0044770 173 0.060
amine metabolic process GO:0009308 44 0.060
positive regulation of catabolic process GO:0009896 310 0.060
proteasomal protein catabolic process GO:0010498 176 0.060
amide biosynthetic process GO:0043604 15 0.059
signal transduction by p53 class mediator GO:0072331 72 0.059
cellular component morphogenesis GO:0032989 314 0.058
histone h3 acetylation GO:0043966 45 0.058
response to oxygen containing compound GO:1901700 369 0.057
megakaryocyte differentiation GO:0030219 25 0.057
regulation of chromatin modification GO:1903308 51 0.057
tissue migration GO:0090130 119 0.056
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 25 0.056
negative regulation of glial cell apoptotic process GO:0034351 6 0.056
regulation of dna repair GO:0006282 47 0.056
negative regulation of cell death GO:0060548 345 0.056
mitotic spindle checkpoint GO:0071174 18 0.055
negative regulation of proteasomal protein catabolic process GO:1901799 32 0.055
positive regulation of protein complex assembly GO:0031334 86 0.055
hematopoietic progenitor cell differentiation GO:0002244 38 0.055
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.054
negative regulation of catalytic activity GO:0043086 335 0.054
production of molecular mediator of immune response GO:0002440 37 0.053
regulation of dna templated transcription elongation GO:0032784 23 0.053
regulation of sister chromatid segregation GO:0033045 27 0.053
negative regulation of sister chromatid segregation GO:0033046 17 0.053
negative regulation of b cell activation GO:0050869 6 0.052
dna catabolic process exonucleolytic GO:0000738 17 0.052
positive regulation of lymphocyte activation GO:0051251 73 0.052
signal transduction by phosphorylation GO:0023014 297 0.052
leukocyte activation GO:0045321 164 0.052
regulation of mitosis GO:0007088 63 0.051
regulation of multi organism process GO:0043900 157 0.051
regulation of hematopoietic progenitor cell differentiation GO:1901532 24 0.050
regulation of cell cycle process GO:0010564 266 0.050
response to purine containing compound GO:0014074 40 0.050
negative regulation of protein metabolic process GO:0051248 391 0.049
adipose tissue development GO:0060612 2 0.049
replication fork processing GO:0031297 13 0.049
regulation of protein autophosphorylation GO:0031952 15 0.049
nervous system development GO:0007399 293 0.049
regulation of cell activation GO:0050865 125 0.049
regulation of nuclear division GO:0051783 65 0.049
regulation of response to external stimulus GO:0032101 222 0.049
regulation of protein catabolic process GO:0042176 155 0.047
positive regulation of growth GO:0045927 58 0.047
regulation of cell development GO:0060284 161 0.047
histone h3 k36 methylation GO:0010452 5 0.047
locomotory behavior GO:0007626 1 0.046
protein polyubiquitination GO:0000209 110 0.046
negative regulation of cellular protein metabolic process GO:0032269 353 0.046
positive regulation of leukocyte activation GO:0002696 80 0.046
gtp catabolic process GO:0006184 237 0.046
response to external biotic stimulus GO:0043207 261 0.045
protein acetylation GO:0006473 116 0.045
meiotic chromosome segregation GO:0045132 4 0.045
regulation of signal transduction by p53 class mediator GO:1901796 26 0.044
negative regulation of transcription elongation from rna polymerase ii promoter GO:0034244 4 0.044
metaphase anaphase transition of cell cycle GO:0044784 21 0.043
lymphocyte activation GO:0046649 133 0.043
organonitrogen compound biosynthetic process GO:1901566 200 0.043
circulatory system development GO:0072359 262 0.042
mitotic sister chromatid separation GO:0051306 18 0.042
positive regulation of cytokine production GO:0001819 167 0.042
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.042
protein modification by small protein removal GO:0070646 92 0.042
hematopoietic or lymphoid organ development GO:0048534 186 0.042
phosphatidylinositol metabolic process GO:0046488 53 0.041
regulation of protein modification by small protein conjugation or removal GO:1903320 107 0.041
positive regulation of cellular component organization GO:0051130 376 0.041
cellular response to ionizing radiation GO:0071479 32 0.041
metaphase anaphase transition of mitotic cell cycle GO:0007091 21 0.041
response to other organism GO:0051707 261 0.041
cardiovascular system development GO:0072358 262 0.041
histone h4 k20 methylation GO:0034770 1 0.040
cellular amide metabolic process GO:0043603 69 0.040
cell part morphogenesis GO:0032990 137 0.040
mitotic spindle assembly checkpoint GO:0007094 14 0.040
positive regulation of programmed cell death GO:0043068 249 0.040
regulation of antimicrobial humoral response GO:0002759 1 0.039
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 2 0.039
response to organonitrogen compound GO:0010243 156 0.038
negative regulation of protein catabolic process GO:0042177 59 0.038
oocyte maturation GO:0001556 1 0.038
regulation of immunoglobulin production GO:0002637 4 0.037
peptide metabolic process GO:0006518 51 0.037
positive regulation of histone h3 k4 methylation GO:0051571 8 0.037
cellular macromolecular complex assembly GO:0034622 324 0.037
cytoplasmic transport GO:0016482 379 0.037
organelle assembly GO:0070925 176 0.036
oogenesis GO:0048477 2 0.036
innate immune response GO:0045087 178 0.036
positive regulation of nucleotide metabolic process GO:0045981 230 0.035
ribonucleoside catabolic process GO:0042454 406 0.035
lymphocyte mediated immunity GO:0002449 48 0.035
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 13 0.035
protein k63 linked ubiquitination GO:0070534 31 0.035
negative regulation of mitotic metaphase anaphase transition GO:0045841 17 0.034
positive regulation of cellular component biogenesis GO:0044089 158 0.034
hair follicle morphogenesis GO:0031069 2 0.034
regulation of peptidase activity GO:0052547 180 0.034
negative regulation of cell differentiation GO:0045596 171 0.034
ameboidal type cell migration GO:0001667 135 0.034
hindlimb morphogenesis GO:0035137 2 0.034
leukocyte mediated immunity GO:0002443 59 0.034
signal transduction involved in mitotic dna integrity checkpoint GO:1902403 13 0.034
regulation of protein ubiquitination GO:0031396 95 0.034
humoral immune response GO:0006959 49 0.033
somatic diversification of immunoglobulins GO:0016445 6 0.033
cell morphogenesis GO:0000902 296 0.033
regulation of defense response GO:0031347 154 0.033
positive regulation of cell proliferation GO:0008284 301 0.033
protein homooligomerization GO:0051260 100 0.032
rho protein signal transduction GO:0007266 26 0.032
cellular response to radiation GO:0071478 65 0.032
telomere maintenance via telomere lengthening GO:0010833 9 0.032
regulation of leukocyte mediated immunity GO:0002703 38 0.032
viral life cycle GO:0019058 132 0.032
organophosphate biosynthetic process GO:0090407 163 0.032
histone h4 acetylation GO:0043967 47 0.032
negative regulation of hydrolase activity GO:0051346 182 0.031
mitotic dna damage checkpoint GO:0044773 28 0.031
positive regulation of b cell activation GO:0050871 17 0.031
protein oligomerization GO:0051259 173 0.031
nucleosome organization GO:0034728 66 0.031
embryonic hindlimb morphogenesis GO:0035116 2 0.031
purine nucleotide catabolic process GO:0006195 405 0.030
regulation of cell motility GO:2000145 299 0.030
epithelial cell migration GO:0010631 119 0.030
nuclear division GO:0000280 128 0.030
positive regulation of mhc class i biosynthetic process GO:0045345 4 0.030
regulation of meiotic cell cycle GO:0051445 4 0.030
dna replication independent nucleosome assembly GO:0006336 27 0.030
negative regulation of cell proliferation GO:0008285 228 0.030
anterior posterior axis specification GO:0009948 2 0.030
cellular response to oxygen containing compound GO:1901701 276 0.030
release of cytoplasmic sequestered nf kappab GO:0008588 4 0.029
cell projection morphogenesis GO:0048858 129 0.029
negative regulation of protein modification process GO:0031400 200 0.029
intracellular mrna localization GO:0008298 1 0.029
guanosine containing compound metabolic process GO:1901068 244 0.029
regulation of cysteine type endopeptidase activity GO:2000116 127 0.029
negative regulation of phosphorus metabolic process GO:0010563 267 0.029
double strand break repair via single strand annealing GO:0045002 4 0.029
negative regulation of phosphorylation GO:0042326 174 0.029
growth GO:0040007 202 0.029
tissue homeostasis GO:0001894 63 0.028
specification of axis polarity GO:0065001 1 0.028
negative regulation of phosphate metabolic process GO:0045936 267 0.028
morphogenesis of embryonic epithelium GO:0016331 4 0.028
regulation of mitotic sister chromatid separation GO:0010965 27 0.028
positive regulation of transport GO:0051050 336 0.028
neural tube formation GO:0001841 3 0.028
positive regulation of gtpase activity GO:0043547 166 0.028
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.028
secretion GO:0046903 254 0.028
demethylation GO:0070988 37 0.028
regulation of gtpase activity GO:0043087 180 0.028
response to gamma radiation GO:0010332 14 0.028
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 35 0.028
positive regulation of immunoglobulin production GO:0002639 4 0.028
histone h3 k79 methylation GO:0034729 2 0.027
regulation of megakaryocyte differentiation GO:0045652 22 0.027
sulfur compound metabolic process GO:0006790 101 0.027
cytokine production GO:0001816 247 0.027
cilium organization GO:0044782 68 0.027
regulation of immune effector process GO:0002697 91 0.027
positive regulation of purine nucleotide catabolic process GO:0033123 185 0.027
peptidyl lysine acetylation GO:0018394 101 0.027
response to uv GO:0009411 73 0.027
dna integrity checkpoint GO:0031570 71 0.027
positive regulation of odontogenesis GO:0042482 3 0.026
regulation of innate immune response GO:0045088 97 0.026
cell growth GO:0016049 160 0.026
central nervous system development GO:0007417 123 0.026
response to organic cyclic compound GO:0014070 204 0.026
nitrogen compound transport GO:0071705 191 0.026
spindle assembly checkpoint GO:0071173 17 0.026
mrna metabolic process GO:0016071 175 0.026
regulation of lymphocyte mediated immunity GO:0002706 33 0.026
guanosine containing compound catabolic process GO:1901069 239 0.026
dna templated transcription elongation GO:0006354 25 0.025
protein k63 linked deubiquitination GO:0070536 21 0.025
establishment or maintenance of cytoskeleton polarity GO:0030952 3 0.025
positive regulation of dna recombination GO:0045911 3 0.025
blastoderm segmentation GO:0007350 2 0.025
axis elongation GO:0003401 4 0.025
double strand break repair via homologous recombination GO:0000724 50 0.025
regulation of b cell mediated immunity GO:0002712 7 0.025
adult locomotory behavior GO:0008344 1 0.025
defense response GO:0006952 315 0.025
b cell mediated immunity GO:0019724 10 0.025
stem cell differentiation GO:0048863 93 0.025
lens development in camera type eye GO:0002088 2 0.024
regulation of gtp catabolic process GO:0033124 180 0.024
positive regulation of ras gtpase activity GO:0032320 117 0.024
nucleoside catabolic process GO:0009164 408 0.024
regulation of endopeptidase activity GO:0052548 170 0.024
intrinsic apoptotic signaling pathway GO:0097193 127 0.024
cell projection organization GO:0030030 252 0.024
regulation of protein stability GO:0031647 87 0.024
positive regulation of signal transduction by p53 class mediator GO:1901798 10 0.024
apoptotic signaling pathway GO:0097190 268 0.024
purine nucleoside triphosphate metabolic process GO:0009144 412 0.024
positive regulation of intracellular protein transport GO:0090316 76 0.024
isotype switching GO:0045190 3 0.024
histone h4 k12 acetylation GO:0043983 6 0.023
blood vessel morphogenesis GO:0048514 162 0.023
gtp metabolic process GO:0046039 239 0.023
regulation of mhc class i biosynthetic process GO:0045343 4 0.023
purine containing compound catabolic process GO:0072523 411 0.023
primary neural tube formation GO:0014020 3 0.023
single organism membrane organization GO:0044802 268 0.023
regulation of cell division GO:0051302 116 0.023
anterior posterior axis specification embryo GO:0008595 2 0.023
intrinsic apoptotic signaling pathway by p53 class mediator GO:0072332 37 0.023
startle response GO:0001964 3 0.023
positive regulation of mapk cascade GO:0043410 190 0.022
regulation of protein localization GO:0032880 296 0.022
system process GO:0003008 349 0.022
protein dephosphorylation GO:0006470 81 0.022
positive regulation of transferase activity GO:0051347 227 0.022
lipoprotein metabolic process GO:0042157 42 0.022
signal transduction involved in dna damage checkpoint GO:0072422 15 0.022
adaptive immune response GO:0002250 49 0.022
positive regulation of intracellular transport GO:0032388 104 0.022
cell division GO:0051301 168 0.022
activation of immune response GO:0002253 114 0.022
regulation of histone acetylation GO:0035065 19 0.022
determination of adult lifespan GO:0008340 2 0.022
chemical homeostasis GO:0048878 306 0.022
positive regulation of cell death GO:0010942 263 0.022
positive regulation of synaptic transmission GO:0050806 4 0.022
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 17 0.022
somitogenesis GO:0001756 2 0.021
rhythmic behavior GO:0007622 2 0.021
carbohydrate metabolic process GO:0005975 207 0.021
regulation of transferase activity GO:0051338 355 0.021
embryo development GO:0009790 123 0.021
histone h4 k5 acetylation GO:0043981 15 0.021
protein localization to organelle GO:0033365 280 0.021
regulation of secretion GO:0051046 194 0.021
negative regulation of programmed cell death GO:0043069 321 0.021
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 116 0.021
neuromuscular junction development GO:0007528 3 0.021
multicellular organismal homeostasis GO:0048871 67 0.021
detection of stimulus GO:0051606 85 0.021
dna damage response detection of dna damage GO:0042769 3 0.021
neuron differentiation GO:0030182 138 0.021
regionalization GO:0003002 29 0.021
regulation of chromatin organization GO:1902275 56 0.021
regulation of locomotion GO:0040012 329 0.020
positive regulation of gtp catabolic process GO:0033126 166 0.020
negative regulation of myeloid cell differentiation GO:0045638 42 0.020
positive regulation of purine nucleotide metabolic process GO:1900544 227 0.020
regulation of viral process GO:0050792 103 0.020
protein localization to membrane GO:0072657 160 0.020
actin filament based process GO:0030029 224 0.020
positive regulation of hydrolase activity GO:0051345 331 0.020
circulatory system process GO:0003013 113 0.020
positive regulation of protein ubiquitination GO:0031398 53 0.020
nucleotide catabolic process GO:0009166 408 0.020
response to nitrogen compound GO:1901698 184 0.019
negative regulation of apoptotic process GO:0043066 316 0.019
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 50 0.019
positive regulation of production of molecular mediator of immune response GO:0002702 11 0.019
cell development GO:0048468 328 0.019
ribonucleoside triphosphate metabolic process GO:0009199 412 0.019
organelle fission GO:0048285 149 0.019
regulation of anatomical structure morphogenesis GO:0022603 286 0.019
nerve development GO:0021675 4 0.019
positive regulation of chromosome organization GO:2001252 41 0.019
regeneration GO:0031099 4 0.019
nuclear transport GO:0051169 179 0.019
endothelial cell migration GO:0043542 86 0.019
cell aging GO:0007569 52 0.019
regulation of cell morphogenesis GO:0022604 153 0.019
negative regulation of dna replication GO:0008156 29 0.019
retina homeostasis GO:0001895 42 0.019
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.019
negative regulation of defense response GO:0031348 47 0.019
positive regulation of protein transport GO:0051222 135 0.019
blastocyst development GO:0001824 3 0.018
phospholipid metabolic process GO:0006644 99 0.018
cellular response to endogenous stimulus GO:0071495 336 0.018
mitotic dna integrity checkpoint GO:0044774 30 0.018
sequestering of calcium ion GO:0051208 17 0.018
cation homeostasis GO:0055080 189 0.018
acetyl coa metabolic process GO:0006084 8 0.018
cell cycle g2 m phase transition GO:0044839 43 0.018
response to lipid GO:0033993 206 0.018
compound eye development GO:0048749 1 0.018
positive regulation of cell cycle GO:0045787 140 0.018
reproductive process GO:0022414 106 0.018
negative regulation of mitosis GO:0045839 24 0.018
cilium morphogenesis GO:0060271 75 0.018
mapk cascade GO:0000165 288 0.018
er nucleus signaling pathway GO:0006984 23 0.018
regulation of mononuclear cell proliferation GO:0032944 65 0.018
hormone metabolic process GO:0042445 61 0.018
neuron death GO:0070997 65 0.018
regulation of nucleotide catabolic process GO:0030811 205 0.018
glycerolipid biosynthetic process GO:0045017 51 0.017

TP53BP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
central nervous system disease DOID:331 186 0.255
nervous system disease DOID:863 431 0.255
breast cancer DOID:1612 21 0.144
thoracic cancer DOID:5093 21 0.144
cancer DOID:162 167 0.144
disease of cellular proliferation DOID:14566 174 0.144
organ system cancer DOID:0050686 164 0.144
neurodegenerative disease DOID:1289 102 0.143
disease of mental health DOID:150 70 0.078
cognitive disorder DOID:1561 29 0.078
tauopathy DOID:680 16 0.065
dementia DOID:1307 19 0.056
alzheimer s disease DOID:10652 16 0.056
musculoskeletal system disease DOID:17 223 0.038
cardiovascular system disease DOID:1287 106 0.037
heart disease DOID:114 68 0.029
immune system disease DOID:2914 155 0.025
neuropathy DOID:870 52 0.023
myopathy DOID:423 104 0.022
muscular disease DOID:0080000 114 0.022
muscular dystrophy DOID:9884 51 0.022
emery dreifuss muscular dystrophy DOID:11726 6 0.022
muscle tissue disease DOID:66 113 0.022
cardiomyopathy DOID:0050700 50 0.021
brain disease DOID:936 73 0.020
connective tissue disease DOID:65 109 0.020
intrinsic cardiomyopathy DOID:0060036 50 0.019
bone disease DOID:0080001 88 0.017