Homo sapiens

49 known processes

TPP1

tripeptidyl peptidase I

(Aliases: LPIC,MGC21297,CLN2)

TPP1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
detection of chemical stimulus GO:0009593 55 0.888
positive regulation of natural killer cell mediated immunity GO:0002717 12 0.567
neurological system process GO:0050877 163 0.471
Mouse
system process GO:0003008 349 0.435
Mouse
anatomical structure homeostasis GO:0060249 100 0.368
vacuole organization GO:0007033 44 0.316
Mouse
cellular lipid catabolic process GO:0044242 65 0.238
detection of chemical stimulus involved in sensory perception GO:0050907 33 0.222
sensory perception of bitter taste GO:0050913 28 0.194
vasculature development GO:0001944 181 0.175
lipid catabolic process GO:0016042 84 0.174
regulation of leukocyte mediated immunity GO:0002703 38 0.174
signal transduction by phosphorylation GO:0023014 297 0.167
sensory perception of taste GO:0050909 36 0.159
negative regulation of multicellular organismal process GO:0051241 317 0.157
locomotory behavior GO:0007626 1 0.153
carbohydrate catabolic process GO:0016052 36 0.143
epithelial cell proliferation GO:0050673 128 0.140
regulation of epithelial cell proliferation GO:0050678 113 0.137
multicellular organismal aging GO:0010259 3 0.136
proteolysis involved in cellular protein catabolic process GO:0051603 244 0.135
carbohydrate metabolic process GO:0005975 207 0.131
protein catabolic process GO:0030163 325 0.128
lipid metabolic process GO:0006629 381 0.128
regulation of defense response GO:0031347 154 0.125
regulation of cellular amino acid metabolic process GO:0006521 6 0.122
protein localization to organelle GO:0033365 280 0.119
cellular amine metabolic process GO:0044106 41 0.114
prostate gland development GO:0030850 3 0.111
negative regulation of dendritic cell differentiation GO:2001199 2 0.108
response to bacterium GO:0009617 144 0.100
post embryonic development GO:0009791 2 0.100
determination of adult lifespan GO:0008340 2 0.096
sensory perception GO:0007600 103 0.095
response to oxygen containing compound GO:1901700 369 0.092
apoptotic signaling pathway GO:0097190 268 0.090
cytokine production GO:0001816 247 0.088
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 181 0.086
cellular amino acid metabolic process GO:0006520 116 0.085
circulatory system development GO:0072359 262 0.082
ganglioside catabolic process GO:0006689 3 0.082
tissue regeneration GO:0042246 3 0.079
cellular homeostasis GO:0019725 196 0.078
cellular macromolecule catabolic process GO:0044265 380 0.076
antigen processing and presentation GO:0019882 33 0.076
regulation of systemic arterial blood pressure by circulatory renin angiotensin GO:0001991 4 0.075
regulation of angiogenesis GO:0045765 92 0.075
multicellular organismal homeostasis GO:0048871 67 0.074
lipid localization GO:0010876 106 0.072
epithelium development GO:0060429 227 0.071
negative regulation of cell proliferation GO:0008285 228 0.071
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 43 0.071
cellular response to hydrogen peroxide GO:0070301 37 0.069
antigen processing and presentation via mhc class ib GO:0002475 3 0.067
protein maturation GO:0051604 233 0.066
positive regulation of immune response GO:0050778 159 0.066
sensory perception of chemical stimulus GO:0007606 38 0.065
nervous system development GO:0007399 293 0.061
immune effector process GO:0002252 159 0.061
regulation of mapk cascade GO:0043408 262 0.060
negative regulation of cellular protein metabolic process GO:0032269 353 0.060
positive regulation of immune system process GO:0002684 283 0.059
leukocyte mediated immunity GO:0002443 59 0.059
positive regulation of t cell tolerance induction GO:0002666 2 0.059
lymphocyte activation GO:0046649 133 0.059
lymphocyte mediated immunity GO:0002449 48 0.058
cellular amide metabolic process GO:0043603 69 0.057
single organism carbohydrate metabolic process GO:0044723 193 0.056
detection of external biotic stimulus GO:0098581 19 0.056
adaptive immune response GO:0002250 49 0.055
positive regulation of cytokine production GO:0001819 167 0.054
metal ion transport GO:0030001 272 0.050
chemical homeostasis GO:0048878 306 0.049
cellular ketone metabolic process GO:0042180 80 0.049
ganglioside metabolic process GO:0001573 7 0.049
oogenesis GO:0048477 2 0.048
amino sugar metabolic process GO:0006040 15 0.047
glycolipid metabolic process GO:0006664 27 0.047
regulation of cytokine production GO:0001817 232 0.046
female gamete generation GO:0007292 2 0.046
positive regulation of lymphocyte activation GO:0051251 73 0.046
regulation of transferase activity GO:0051338 355 0.046
positive regulation of defense response GO:0031349 87 0.045
positive regulation of innate immune response GO:0045089 79 0.044
proteasomal protein catabolic process GO:0010498 176 0.044
positive regulation of cell activation GO:0050867 81 0.043
mating GO:0007618 1 0.043
cellular response to endogenous stimulus GO:0071495 336 0.043
innate immune response GO:0045087 178 0.043
cell development GO:0048468 328 0.042
negative regulation of immune system process GO:0002683 136 0.041
negative regulation of glycoprotein metabolic process GO:1903019 8 0.040
regulation of lymphocyte activation GO:0051249 103 0.040
negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 2 0.039
regulation of natural killer cell mediated immunity GO:0002715 16 0.038
modification dependent protein catabolic process GO:0019941 209 0.038
protection from natural killer cell mediated cytotoxicity GO:0042270 3 0.038
reproductive process GO:0022414 106 0.038
immune response GO:0006955 307 0.038
regulation of cellular ketone metabolic process GO:0010565 50 0.037
long term memory GO:0007616 2 0.037
anatomical structure formation involved in morphogenesis GO:0048646 284 0.037
cellular protein catabolic process GO:0044257 261 0.037
wnt signaling pathway GO:0016055 156 0.037
regulation of lymphocyte proliferation GO:0050670 64 0.036
cellular response to thyroid hormone stimulus GO:0097067 9 0.036
membrane lipid metabolic process GO:0006643 53 0.036
positive regulation of cellular amine metabolic process GO:0033240 7 0.036
response to thyroid hormone GO:0097066 9 0.035
intracellular protein transport GO:0006886 270 0.035
regulation of lipid metabolic process GO:0019216 96 0.035
defense response GO:0006952 315 0.035
immune response regulating signaling pathway GO:0002764 97 0.035
detection of biotic stimulus GO:0009595 21 0.035
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 156 0.034
antigen processing and presentation of peptide antigen GO:0048002 18 0.034
peripheral nervous system development GO:0007422 2 0.034
detection of chemical stimulus involved in sensory perception of taste GO:0050912 31 0.034
cell morphogenesis GO:0000902 296 0.034
positive regulation of mapk cascade GO:0043410 190 0.033
response to oxidative stress GO:0006979 121 0.033
ion homeostasis GO:0050801 230 0.033
cellular ion homeostasis GO:0006873 168 0.033
regulation of immune response GO:0050776 201 0.032
growth GO:0040007 202 0.032
immune response regulating cell surface receptor signaling pathway GO:0002768 51 0.032
regulation of blood vessel remodeling GO:0060312 2 0.032
negative regulation of cell death GO:0060548 345 0.031
leukocyte activation GO:0045321 164 0.031
regeneration GO:0031099 4 0.031
modification dependent macromolecule catabolic process GO:0043632 212 0.031
positive regulation of lymphocyte differentiation GO:0045621 13 0.031
cell projection organization GO:0030030 252 0.030
negative regulation of immune response GO:0050777 40 0.030
positive regulation of interferon gamma production GO:0032729 26 0.030
enzyme linked receptor protein signaling pathway GO:0007167 303 0.030
tissue homeostasis GO:0001894 63 0.030
liposaccharide metabolic process GO:1903509 27 0.029
detection of stimulus GO:0051606 85 0.029
negative regulation of elastin catabolic process GO:0060311 1 0.029
immune response inhibiting cell surface receptor signaling pathway GO:0002767 4 0.028
positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002824 19 0.028
positive regulation of interleukin 12 production GO:0032735 8 0.028
regulation of cellular amine metabolic process GO:0033238 11 0.027
response to organonitrogen compound GO:0010243 156 0.027
regulation of regulatory t cell differentiation GO:0045589 4 0.027
cell adhesion GO:0007155 325 0.027
amine metabolic process GO:0009308 44 0.027
regulation of vasculature development GO:1901342 97 0.027
regulation of cell activation GO:0050865 125 0.027
cellular response to reactive oxygen species GO:0034614 50 0.026
regulation of tolerance induction GO:0002643 4 0.026
transition metal ion transport GO:0000041 23 0.026
positive regulation of regulatory t cell differentiation GO:0045591 3 0.025
detection of stimulus involved in sensory perception GO:0050906 43 0.025
regulation of cellular response to stress GO:0080135 244 0.025
regulation of wnt signaling pathway GO:0030111 123 0.025
retina homeostasis GO:0001895 42 0.025
regulation of protein maturation GO:1903317 150 0.025
cation transport GO:0006812 331 0.025
gland development GO:0048732 48 0.025
blastocyst development GO:0001824 3 0.024
regulation of leukocyte differentiation GO:1902105 61 0.024
cellular lipid metabolic process GO:0044255 303 0.024
negative regulation of vasculature development GO:1901343 43 0.024
positive regulation of leukocyte mediated immunity GO:0002705 24 0.024
positive regulation of immune effector process GO:0002699 40 0.024
regulation of elastin catabolic process GO:0060310 1 0.024
ubiquitin dependent protein catabolic process GO:0006511 206 0.023
regulation of t cell activation GO:0050863 77 0.023
neuromuscular process GO:0050905 15 0.023
Mouse
maintenance of location GO:0051235 112 0.023
regulation of secretion GO:0051046 194 0.023
intracellular receptor signaling pathway GO:0030522 104 0.023
vesicle mediated transport GO:0016192 371 0.023
regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002822 29 0.023
regulation of intracellular transport GO:0032386 195 0.022
sulfur compound metabolic process GO:0006790 101 0.022
neuronal action potential GO:0019228 9 0.022
cytoplasmic transport GO:0016482 379 0.022
cell activation GO:0001775 213 0.022
response to other organism GO:0051707 261 0.022
response to hormone GO:0009725 175 0.022
blood vessel morphogenesis GO:0048514 162 0.021
regulation of protein transport GO:0051223 213 0.021
memory GO:0007613 3 0.021
regulation of leukocyte activation GO:0002694 115 0.021
inorganic ion transmembrane transport GO:0098660 231 0.021
regulation of angiotensin levels in blood GO:0002002 3 0.021
regulation of kinase activity GO:0043549 314 0.021
single organism reproductive process GO:0044702 98 0.021
positive regulation of aldosterone biosynthetic process GO:0032349 2 0.021
positive regulation of cell proliferation GO:0008284 301 0.021
urogenital system development GO:0001655 65 0.020
regulation of natural killer cell mediated cytotoxicity GO:0042269 16 0.020
negative regulation of collagen catabolic process GO:0010711 1 0.020
endosomal transport GO:0016197 129 0.020
hemopoiesis GO:0030097 180 0.020
single organism membrane organization GO:0044802 268 0.020
negative regulation of developmental process GO:0051093 247 0.020
t cell differentiation GO:0030217 29 0.020
regulation of peptidyl tyrosine phosphorylation GO:0050730 108 0.020
cellular response to oxygen containing compound GO:1901701 276 0.020
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 40 0.020
positive regulation of cellular amino acid metabolic process GO:0045764 3 0.019
regulation of establishment of protein localization GO:0070201 242 0.019
t cell tolerance induction GO:0002517 4 0.019
secretion GO:0046903 254 0.019
negative regulation of phosphorus metabolic process GO:0010563 267 0.018
neurogenesis GO:0022008 169 0.018
monovalent inorganic cation transport GO:0015672 128 0.018
negative regulation of cellular response to oxidative stress GO:1900408 18 0.018
negative regulation of metalloenzyme activity GO:0048553 1 0.018
negative regulation of intracellular signal transduction GO:1902532 183 0.018
response to wounding GO:0009611 168 0.018
positive regulation of t cell activation GO:0050870 54 0.018
regulation of protein localization GO:0032880 296 0.018
positive regulation of tolerance induction GO:0002645 2 0.018
negative regulation of catalytic activity GO:0043086 335 0.017
regulation of protein kinase activity GO:0045859 289 0.017
embryo development GO:0009790 123 0.017
response to nitrogen compound GO:1901698 184 0.017
dna replication GO:0006260 116 0.017
negative regulation of phosphate metabolic process GO:0045936 267 0.017
angiogenesis GO:0001525 147 0.017
regulation of endothelial cell proliferation GO:0001936 56 0.017
establishment of protein localization to organelle GO:0072594 172 0.017
oocyte differentiation GO:0009994 2 0.017
positive regulation of leukocyte differentiation GO:1902107 37 0.017
endothelial cell proliferation GO:0001935 65 0.017
positive regulation of developmental process GO:0051094 314 0.017
regulation of collagen catabolic process GO:0010710 3 0.017
response to axon injury GO:0048678 1 0.017
cellular response to oxidative stress GO:0034599 85 0.017
immune response inhibiting signal transduction GO:0002765 4 0.017
regulation of protein catabolic process GO:0042176 155 0.016
peptidyl tyrosine phosphorylation GO:0018108 170 0.016
regulation of cell killing GO:0031341 22 0.016
blastoderm segmentation GO:0007350 2 0.016
generation of neurons GO:0048699 152 0.016
regulation of lymphocyte mediated immunity GO:0002706 33 0.016
transmembrane transport GO:0055085 399 0.016
somatic muscle development GO:0007525 1 0.016
positive regulation of phosphorylation GO:0042327 394 0.016
regulation of cellular response to growth factor stimulus GO:0090287 76 0.016
regulation of innate immune response GO:0045088 97 0.016
response to reactive oxygen species GO:0000302 61 0.016
t cell activation GO:0042110 99 0.016
negative regulation of programmed cell death GO:0043069 321 0.015
neuromuscular process controlling posture GO:0050884 2 0.015
response to biotic stimulus GO:0009607 276 0.015
behavior GO:0007610 112 0.015
regulation of immune effector process GO:0002697 91 0.015
regulation of anatomical structure morphogenesis GO:0022603 286 0.015
negative regulation of epithelial cell proliferation GO:0050680 48 0.015
positive regulation of epithelial cell proliferation GO:0050679 65 0.015
hematopoietic or lymphoid organ development GO:0048534 186 0.015
positive regulation of secretion GO:0051047 116 0.015
blood vessel development GO:0001568 172 0.015
negative regulation of cellular amine metabolic process GO:0033239 3 0.015
regulation of oxidative stress induced cell death GO:1903201 24 0.015
negative regulation of protein modification process GO:0031400 200 0.015
neuron differentiation GO:0030182 138 0.015
head development GO:0060322 108 0.015
mapk cascade GO:0000165 288 0.015
positive regulation of aldosterone metabolic process GO:0032346 2 0.015
multicellular organismal metabolic process GO:0044236 34 0.014
positive regulation of leukocyte activation GO:0002696 80 0.014
lipid transport GO:0006869 90 0.014
negative regulation of cellular catabolic process GO:0031330 83 0.014
regulation of t cell tolerance induction GO:0002664 4 0.014
action potential GO:0001508 34 0.014
circulatory system process GO:0003013 113 0.014
respiratory system process GO:0003016 3 0.014
regulation of anatomical structure size GO:0090066 101 0.014
oxidation reduction process GO:0055114 396 0.014
negative regulation of protein metabolic process GO:0051248 391 0.014
negative regulation of oxidative stress induced cell death GO:1903202 17 0.014
regulation of t cell differentiation GO:0045580 19 0.014
segmentation GO:0035282 4 0.014
neuron projection development GO:0031175 106 0.014
regulation of cytokine secretion GO:0050707 57 0.014
monovalent inorganic cation homeostasis GO:0055067 37 0.013
natural killer cell mediated cytotoxicity GO:0042267 23 0.013
t cell proliferation GO:0042098 45 0.013
protein modification by small protein conjugation GO:0032446 342 0.013
protein processing GO:0016485 226 0.013
interferon gamma production GO:0032609 39 0.013
response to organic cyclic compound GO:0014070 204 0.013
divalent inorganic cation homeostasis GO:0072507 136 0.013
positive regulation of leukocyte degranulation GO:0043302 3 0.013
muscle cell cellular homeostasis GO:0046716 3 0.013
positive regulation of steroid hormone biosynthetic process GO:0090031 2 0.013
kidney development GO:0001822 53 0.013
response to external biotic stimulus GO:0043207 261 0.013
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 41 0.012
defense response to bacterium GO:0042742 63 0.012
cellular response to hormone stimulus GO:0032870 125 0.012
regulation of adaptive immune response GO:0002819 33 0.012
cell killing GO:0001906 34 0.012
dephosphorylation GO:0016311 209 0.012
neuron development GO:0048666 113 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 125 0.012
regulation of systemic arterial blood pressure by hormone GO:0001990 12 0.012
cell death in response to hydrogen peroxide GO:0036474 10 0.012
single organism carbohydrate catabolic process GO:0044724 33 0.012
protein oligomerization GO:0051259 173 0.012
positive regulation of cell cycle GO:0045787 140 0.012
positive regulation of lymphocyte mediated immunity GO:0002708 23 0.012
negative regulation of transferase activity GO:0051348 124 0.012
cellular response to extracellular stimulus GO:0031668 72 0.012
positive regulation of transport GO:0051050 336 0.012
vacuolar transport GO:0007034 34 0.012
lytic vacuole organization GO:0080171 24 0.012
Mouse
response to hydrogen peroxide GO:0042542 40 0.011
cellular carbohydrate metabolic process GO:0044262 84 0.011
nucleocytoplasmic transport GO:0006913 176 0.011
negative regulation of cell motility GO:2000146 104 0.011
central nervous system development GO:0007417 123 0.011
positive regulation of protein kinase activity GO:0045860 190 0.011
multicellular organismal signaling GO:0035637 34 0.011
negative regulation of blood vessel morphogenesis GO:2000181 41 0.011
heparan sulfate proteoglycan metabolic process GO:0030201 12 0.011
cellular component morphogenesis GO:0032989 314 0.011
negative regulation of protein catabolic process GO:0042177 59 0.011
negative regulation of cellular amino acid metabolic process GO:0045763 2 0.011
regulation of interferon gamma production GO:0032649 36 0.011
regulation of membrane potential GO:0042391 95 0.011
immune system development GO:0002520 195 0.011
anion transport GO:0006820 161 0.011
regulation of hydrogen peroxide induced cell death GO:1903205 10 0.011
diaphragm contraction GO:0002086 1 0.011
positive regulation of dna metabolic process GO:0051054 73 0.011
transmission of nerve impulse GO:0019226 11 0.011
negative regulation of catabolic process GO:0009895 104 0.011
secretion by cell GO:0032940 226 0.011
positive regulation of kinase activity GO:0033674 204 0.011
response to abiotic stimulus GO:0009628 336 0.011
positive regulation of t cell differentiation GO:0045582 11 0.011
negative regulation of hydrolase activity GO:0051346 182 0.011
nuclear transport GO:0051169 179 0.011
response to peptide hormone GO:0043434 61 0.011
ossification GO:0001503 121 0.011
sensory perception of sound GO:0007605 37 0.011
cardiovascular system development GO:0072358 262 0.011
sensory perception of mechanical stimulus GO:0050954 37 0.011
cellular protein complex assembly GO:0043623 188 0.011
divalent inorganic cation transport GO:0072511 158 0.011
positive regulation of intracellular transport GO:0032388 104 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 90 0.010
adenylate cyclase inhibiting g protein coupled receptor signaling pathway GO:0007193 22 0.010
purine containing compound catabolic process GO:0072523 411 0.010
leukocyte differentiation GO:0002521 98 0.010
negative regulation of cell migration GO:0030336 102 0.010
negative regulation of cell differentiation GO:0045596 171 0.010
establishment of planar polarity GO:0001736 3 0.010
regulation of interleukin 12 production GO:0032655 15 0.010
sensory perception of pain GO:0019233 4 0.010
cell projection morphogenesis GO:0048858 129 0.010
detection of chemical stimulus involved in sensory perception of bitter taste GO:0001580 28 0.010

TPP1 disease predictions

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 295 1.000
lysosomal storage disease DOID:3211 47 1.000
inherited metabolic disorder DOID:655 242 1.000
lipid storage disease DOID:9455 28 0.968
central nervous system disease DOID:331 186 0.730
nervous system disease DOID:863 431 0.730
neuronal ceroid lipofuscinosis DOID:14503 11 0.552
brain disease DOID:936 73 0.247
sphingolipidosis DOID:1927 14 0.137
cerebral degeneration DOID:1443 16 0.059
leukodystrophy DOID:10579 8 0.059
epilepsy syndrome DOID:1826 41 0.032
variable age at onset electroclinical syndrome DOID:0050706 8 0.032
electroclinical syndrome DOID:0050701 32 0.032
progressive myoclonus epilepsy DOID:891 8 0.032
immune system disease DOID:2914 155 0.016
sensory system disease DOID:0050155 203 0.016
neurodegenerative disease DOID:1289 102 0.011